-- dump date 20140619_002556 -- class Genbank::misc_feature -- table misc_feature_note -- id note 890402000001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 890402000002 Integrase core domain; Region: rve; pfam00665 890402000003 putative transposase OrfB; Reviewed; Region: PHA02517 890402000004 HTH-like domain; Region: HTH_21; pfam13276 890402000005 Integrase core domain; Region: rve; pfam00665 890402000006 Integrase core domain; Region: rve_2; pfam13333 890402000007 Homeodomain-like domain; Region: HTH_23; cl17451 890402000008 Helix-turn-helix domain; Region: HTH_28; pfam13518 890402000009 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 890402000010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 890402000011 non-specific DNA binding site [nucleotide binding]; other site 890402000012 salt bridge; other site 890402000013 sequence-specific DNA binding site [nucleotide binding]; other site 890402000014 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 890402000015 AAA domain; Region: AAA_14; pfam13173 890402000016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 890402000017 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 890402000018 non-specific DNA binding site [nucleotide binding]; other site 890402000019 salt bridge; other site 890402000020 sequence-specific DNA binding site [nucleotide binding]; other site 890402000021 putative transposase OrfB; Reviewed; Region: PHA02517 890402000022 HTH-like domain; Region: HTH_21; pfam13276 890402000023 Integrase core domain; Region: rve; pfam00665 890402000024 Integrase core domain; Region: rve_2; pfam13333 890402000025 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 890402000026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 890402000027 DNA-binding interface [nucleotide binding]; DNA binding site 890402000028 Integrase core domain; Region: rve; pfam00665 890402000029 transposase/IS protein; Provisional; Region: PRK09183 890402000030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402000031 Walker A motif; other site 890402000032 ATP binding site [chemical binding]; other site 890402000033 Walker B motif; other site 890402000034 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 890402000035 S-adenosylmethionine synthetase; Validated; Region: PRK05250 890402000036 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 890402000037 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 890402000038 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 890402000039 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 890402000040 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 890402000041 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 890402000042 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 890402000043 putative active site [active] 890402000044 substrate binding site [chemical binding]; other site 890402000045 putative cosubstrate binding site; other site 890402000046 catalytic site [active] 890402000047 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 890402000048 substrate binding site [chemical binding]; other site 890402000049 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 890402000050 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 890402000051 primosome assembly protein PriA; Provisional; Region: PRK14873 890402000052 phosphoserine phosphatase SerB; Region: serB; TIGR00338 890402000053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 890402000054 motif II; other site 890402000055 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 890402000056 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 890402000057 proteasome ATPase; Region: pup_AAA; TIGR03689 890402000058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402000059 Walker A motif; other site 890402000060 ATP binding site [chemical binding]; other site 890402000061 Walker B motif; other site 890402000062 arginine finger; other site 890402000063 Pup-ligase protein; Region: Pup_ligase; cl15463 890402000064 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 890402000065 active site 890402000066 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 890402000067 ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687 890402000068 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 890402000069 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 890402000070 IHF dimer interface [polypeptide binding]; other site 890402000071 IHF - DNA interface [nucleotide binding]; other site 890402000072 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 890402000073 adenylosuccinate lyase; Provisional; Region: PRK09285 890402000074 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 890402000075 tetramer interface [polypeptide binding]; other site 890402000076 active site 890402000077 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 890402000078 PGAP1-like protein; Region: PGAP1; pfam07819 890402000079 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 890402000080 metal ion-dependent adhesion site (MIDAS); other site 890402000081 von Willebrand factor type A domain; Region: VWA_2; pfam13519 890402000082 Protein of unknown function DUF58; Region: DUF58; pfam01882 890402000083 MoxR-like ATPases [General function prediction only]; Region: COG0714 890402000084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 890402000085 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 890402000086 ligand binding site [chemical binding]; other site 890402000087 active site 890402000088 UGI interface [polypeptide binding]; other site 890402000089 catalytic site [active] 890402000090 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 890402000091 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 890402000092 DNA-binding site [nucleotide binding]; DNA binding site 890402000093 RNA-binding motif; other site 890402000094 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 890402000095 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 890402000096 ring oligomerisation interface [polypeptide binding]; other site 890402000097 ATP/Mg binding site [chemical binding]; other site 890402000098 stacking interactions; other site 890402000099 hinge regions; other site 890402000100 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 890402000101 Repair protein; Region: Repair_PSII; cl01535 890402000102 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 890402000103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 890402000104 active site 890402000105 phosphorylation site [posttranslational modification] 890402000106 intermolecular recognition site; other site 890402000107 dimerization interface [polypeptide binding]; other site 890402000108 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 890402000109 DNA binding site [nucleotide binding] 890402000110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 890402000111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 890402000112 dimerization interface [polypeptide binding]; other site 890402000113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 890402000114 dimer interface [polypeptide binding]; other site 890402000115 phosphorylation site [posttranslational modification] 890402000116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 890402000117 ATP binding site [chemical binding]; other site 890402000118 Mg2+ binding site [ion binding]; other site 890402000119 G-X-G motif; other site 890402000120 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 890402000121 DNA-binding site [nucleotide binding]; DNA binding site 890402000122 RNA-binding motif; other site 890402000123 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 890402000124 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 890402000125 Ligand Binding Site [chemical binding]; other site 890402000126 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 890402000127 Ligand Binding Site [chemical binding]; other site 890402000128 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 890402000129 Clp amino terminal domain; Region: Clp_N; pfam02861 890402000130 Clp amino terminal domain; Region: Clp_N; pfam02861 890402000131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402000132 Walker A motif; other site 890402000133 ATP binding site [chemical binding]; other site 890402000134 Walker B motif; other site 890402000135 arginine finger; other site 890402000136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402000137 Walker A motif; other site 890402000138 ATP binding site [chemical binding]; other site 890402000139 Walker B motif; other site 890402000140 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 890402000141 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 890402000142 cytosine deaminase; Provisional; Region: PRK09230 890402000143 active site 890402000144 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 890402000145 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 890402000146 Creatinine amidohydrolase; Region: Creatininase; pfam02633 890402000147 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 890402000148 active site 890402000149 metal binding site [ion binding]; metal-binding site 890402000150 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 890402000151 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 890402000152 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 890402000153 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 890402000154 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 890402000155 dimer interface [polypeptide binding]; other site 890402000156 motif 1; other site 890402000157 active site 890402000158 motif 2; other site 890402000159 motif 3; other site 890402000160 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 890402000161 anticodon binding site; other site 890402000162 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 890402000163 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 890402000164 dimer interface [polypeptide binding]; other site 890402000165 anticodon binding site; other site 890402000166 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 890402000167 motif 1; other site 890402000168 dimer interface [polypeptide binding]; other site 890402000169 active site 890402000170 motif 2; other site 890402000171 GAD domain; Region: GAD; pfam02938 890402000172 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 890402000173 active site 890402000174 motif 3; other site 890402000175 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 890402000176 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 890402000177 Walker A/P-loop; other site 890402000178 ATP binding site [chemical binding]; other site 890402000179 Q-loop/lid; other site 890402000180 ABC transporter signature motif; other site 890402000181 Walker B; other site 890402000182 D-loop; other site 890402000183 H-loop/switch region; other site 890402000184 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 890402000185 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 890402000186 substrate binding pocket [chemical binding]; other site 890402000187 membrane-bound complex binding site; other site 890402000188 hinge residues; other site 890402000189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402000190 dimer interface [polypeptide binding]; other site 890402000191 conserved gate region; other site 890402000192 ABC-ATPase subunit interface; other site 890402000193 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 890402000194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402000195 dimer interface [polypeptide binding]; other site 890402000196 conserved gate region; other site 890402000197 putative PBP binding loops; other site 890402000198 ABC-ATPase subunit interface; other site 890402000199 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 890402000200 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 890402000201 active site 890402000202 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 890402000203 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 890402000204 ATP binding site [chemical binding]; other site 890402000205 putative Mg++ binding site [ion binding]; other site 890402000206 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 890402000207 nucleotide binding region [chemical binding]; other site 890402000208 ATP-binding site [chemical binding]; other site 890402000209 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 890402000210 recombination factor protein RarA; Reviewed; Region: PRK13342 890402000211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402000212 Walker A motif; other site 890402000213 ATP binding site [chemical binding]; other site 890402000214 Walker B motif; other site 890402000215 arginine finger; other site 890402000216 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 890402000217 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 890402000218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 890402000219 active site 890402000220 phosphorylation site [posttranslational modification] 890402000221 intermolecular recognition site; other site 890402000222 dimerization interface [polypeptide binding]; other site 890402000223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 890402000224 DNA binding site [nucleotide binding] 890402000225 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 890402000226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 890402000227 dimerization interface [polypeptide binding]; other site 890402000228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 890402000229 dimer interface [polypeptide binding]; other site 890402000230 phosphorylation site [posttranslational modification] 890402000231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 890402000232 ATP binding site [chemical binding]; other site 890402000233 Mg2+ binding site [ion binding]; other site 890402000234 G-X-G motif; other site 890402000235 lipoprotein LpqB; Provisional; Region: PRK13613 890402000236 Sporulation and spore germination; Region: Germane; pfam10646 890402000237 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 890402000238 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 890402000239 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 890402000240 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 890402000241 Walker A/P-loop; other site 890402000242 ATP binding site [chemical binding]; other site 890402000243 Q-loop/lid; other site 890402000244 ABC transporter signature motif; other site 890402000245 Walker B; other site 890402000246 D-loop; other site 890402000247 H-loop/switch region; other site 890402000248 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 890402000249 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 890402000250 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 890402000251 TM-ABC transporter signature motif; other site 890402000252 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 890402000253 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 890402000254 TM-ABC transporter signature motif; other site 890402000255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402000256 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 890402000257 putative substrate translocation pore; other site 890402000258 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 890402000259 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 890402000260 NAD binding site [chemical binding]; other site 890402000261 ligand binding site [chemical binding]; other site 890402000262 catalytic site [active] 890402000263 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 890402000264 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 890402000265 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 890402000266 Walker A/P-loop; other site 890402000267 ATP binding site [chemical binding]; other site 890402000268 Q-loop/lid; other site 890402000269 ABC transporter signature motif; other site 890402000270 Walker B; other site 890402000271 D-loop; other site 890402000272 H-loop/switch region; other site 890402000273 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 890402000274 Walker A/P-loop; other site 890402000275 ATP binding site [chemical binding]; other site 890402000276 Q-loop/lid; other site 890402000277 ABC transporter signature motif; other site 890402000278 Walker B; other site 890402000279 D-loop; other site 890402000280 H-loop/switch region; other site 890402000281 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 890402000282 Predicted membrane protein [Function unknown]; Region: COG3601 890402000283 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 890402000284 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 890402000285 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 890402000286 Probable Catalytic site; other site 890402000287 Nitroreductase family; Region: Nitroreductase; pfam00881 890402000288 FMN binding site [chemical binding]; other site 890402000289 dimer interface [polypeptide binding]; other site 890402000290 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 890402000291 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 890402000292 nucleotide binding site [chemical binding]; other site 890402000293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 890402000294 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 890402000295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402000296 homodimer interface [polypeptide binding]; other site 890402000297 catalytic residue [active] 890402000298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402000299 Walker A/P-loop; other site 890402000300 ATP binding site [chemical binding]; other site 890402000301 ABC transporter; Region: ABC_tran; pfam00005 890402000302 ABC transporter signature motif; other site 890402000303 Walker B; other site 890402000304 D-loop; other site 890402000305 H-loop/switch region; other site 890402000306 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 890402000307 TPR repeat; Region: TPR_11; pfam13414 890402000308 Ligase N family; Region: LIGANc; smart00532 890402000309 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 890402000310 nucleotide binding pocket [chemical binding]; other site 890402000311 K-X-D-G motif; other site 890402000312 catalytic site [active] 890402000313 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 890402000314 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 890402000315 Helix-hairpin-helix motif; Region: HHH; pfam00633 890402000316 helix-hairpin-helix signature motif; other site 890402000317 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 890402000318 Dimer interface [polypeptide binding]; other site 890402000319 Domain of unknown function DUF59; Region: DUF59; cl00941 890402000320 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 890402000321 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 890402000322 Walker A motif; other site 890402000323 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 890402000324 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 890402000325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402000326 dimer interface [polypeptide binding]; other site 890402000327 conserved gate region; other site 890402000328 putative PBP binding loops; other site 890402000329 ABC-ATPase subunit interface; other site 890402000330 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 890402000331 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 890402000332 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 890402000333 putative active site [active] 890402000334 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 890402000335 putative alpha-glucosidase; Provisional; Region: PRK10658 890402000336 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 890402000337 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 890402000338 active site 890402000339 homotrimer interface [polypeptide binding]; other site 890402000340 catalytic site [active] 890402000341 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 890402000342 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 890402000343 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 890402000344 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 890402000345 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 890402000346 catalytic residues [active] 890402000347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 890402000348 S-adenosylmethionine binding site [chemical binding]; other site 890402000349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 890402000350 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 890402000351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 890402000352 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 890402000353 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 890402000354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402000355 Walker A/P-loop; other site 890402000356 ATP binding site [chemical binding]; other site 890402000357 Q-loop/lid; other site 890402000358 ABC transporter signature motif; other site 890402000359 Walker B; other site 890402000360 D-loop; other site 890402000361 H-loop/switch region; other site 890402000362 elongation factor P; Validated; Region: PRK00529 890402000363 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 890402000364 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 890402000365 RNA binding site [nucleotide binding]; other site 890402000366 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 890402000367 RNA binding site [nucleotide binding]; other site 890402000368 transcription antitermination factor NusB; Region: nusB; TIGR01951 890402000369 putative RNA binding site [nucleotide binding]; other site 890402000370 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 890402000371 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 890402000372 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 890402000373 catalytic site [active] 890402000374 subunit interface [polypeptide binding]; other site 890402000375 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 890402000376 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 890402000377 ATP-grasp domain; Region: ATP-grasp_4; cl17255 890402000378 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 890402000379 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 890402000380 ATP-grasp domain; Region: ATP-grasp_4; cl17255 890402000381 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 890402000382 IMP binding site; other site 890402000383 dimer interface [polypeptide binding]; other site 890402000384 interdomain contacts; other site 890402000385 partial ornithine binding site; other site 890402000386 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 890402000387 active site 890402000388 dimer interface [polypeptide binding]; other site 890402000389 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 890402000390 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 890402000391 catalytic site [active] 890402000392 G-X2-G-X-G-K; other site 890402000393 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 890402000394 active site 890402000395 catalytic site [active] 890402000396 substrate binding site [chemical binding]; other site 890402000397 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 890402000398 elongation factor G; Reviewed; Region: PRK12740 890402000399 G1 box; other site 890402000400 putative GEF interaction site [polypeptide binding]; other site 890402000401 GTP/Mg2+ binding site [chemical binding]; other site 890402000402 Switch I region; other site 890402000403 G2 box; other site 890402000404 G3 box; other site 890402000405 Switch II region; other site 890402000406 G4 box; other site 890402000407 G5 box; other site 890402000408 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 890402000409 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 890402000410 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 890402000411 Predicted esterase [General function prediction only]; Region: COG0400 890402000412 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 890402000413 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 890402000414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402000415 dimer interface [polypeptide binding]; other site 890402000416 conserved gate region; other site 890402000417 putative PBP binding loops; other site 890402000418 ABC-ATPase subunit interface; other site 890402000419 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 890402000420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402000421 dimer interface [polypeptide binding]; other site 890402000422 conserved gate region; other site 890402000423 putative PBP binding loops; other site 890402000424 ABC-ATPase subunit interface; other site 890402000425 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 890402000426 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 890402000427 Walker A/P-loop; other site 890402000428 ATP binding site [chemical binding]; other site 890402000429 Q-loop/lid; other site 890402000430 ABC transporter signature motif; other site 890402000431 Walker B; other site 890402000432 D-loop; other site 890402000433 H-loop/switch region; other site 890402000434 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 890402000435 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 890402000436 substrate binding pocket [chemical binding]; other site 890402000437 membrane-bound complex binding site; other site 890402000438 hinge residues; other site 890402000439 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 890402000440 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 890402000441 homodimer interface [polypeptide binding]; other site 890402000442 substrate-cofactor binding pocket; other site 890402000443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402000444 catalytic residue [active] 890402000445 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 890402000446 catalytic residues [active] 890402000447 Predicted transcriptional regulator [Transcription]; Region: COG1959 890402000448 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 890402000449 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 890402000450 NIL domain; Region: NIL; pfam09383 890402000451 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 890402000452 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 890402000453 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 890402000454 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 890402000455 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 890402000456 active site 890402000457 nucleophile elbow; other site 890402000458 glutamate racemase; Provisional; Region: PRK00865 890402000459 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 890402000460 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 890402000461 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 890402000462 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 890402000463 putative active site [active] 890402000464 redox center [active] 890402000465 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 890402000466 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 890402000467 active site 890402000468 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 890402000469 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 890402000470 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 890402000471 substrate binding site [chemical binding]; other site 890402000472 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 890402000473 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 890402000474 Family description; Region: UvrD_C_2; pfam13538 890402000475 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 890402000476 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 890402000477 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 890402000478 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 890402000479 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 890402000480 DivIVA domain; Region: DivI1A_domain; TIGR03544 890402000481 DivIVA domain; Region: DivI1A_domain; TIGR03544 890402000482 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 890402000483 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 890402000484 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 890402000485 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 890402000486 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 890402000487 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 890402000488 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 890402000489 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 890402000490 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 890402000491 Recombination protein O N terminal; Region: RecO_N; pfam11967 890402000492 Recombination protein O C terminal; Region: RecO_C; pfam02565 890402000493 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 890402000494 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 890402000495 catalytic residue [active] 890402000496 putative FPP diphosphate binding site; other site 890402000497 putative FPP binding hydrophobic cleft; other site 890402000498 dimer interface [polypeptide binding]; other site 890402000499 putative IPP diphosphate binding site; other site 890402000500 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 890402000501 active site 890402000502 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 890402000503 active site 890402000504 NMT1/THI5 like; Region: NMT1; pfam09084 890402000505 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 890402000506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402000507 dimer interface [polypeptide binding]; other site 890402000508 conserved gate region; other site 890402000509 putative PBP binding loops; other site 890402000510 ABC-ATPase subunit interface; other site 890402000511 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 890402000512 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 890402000513 substrate binding [chemical binding]; other site 890402000514 active site 890402000515 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 890402000516 galactoside permease; Reviewed; Region: lacY; PRK09528 890402000517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402000518 putative substrate translocation pore; other site 890402000519 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402000520 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402000521 DNA binding site [nucleotide binding] 890402000522 domain linker motif; other site 890402000523 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 890402000524 putative dimerization interface [polypeptide binding]; other site 890402000525 putative ligand binding site [chemical binding]; other site 890402000526 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 890402000527 serpin-like protein; Provisional; Region: PHA02660 890402000528 reactive center loop; other site 890402000529 benzoate transport; Region: 2A0115; TIGR00895 890402000530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402000531 putative substrate translocation pore; other site 890402000532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402000533 putative substrate translocation pore; other site 890402000534 Domain of unknown function DUF77; Region: DUF77; pfam01910 890402000535 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 890402000536 substrate binding site [chemical binding]; other site 890402000537 dimer interface [polypeptide binding]; other site 890402000538 ATP binding site [chemical binding]; other site 890402000539 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 890402000540 thiamine phosphate binding site [chemical binding]; other site 890402000541 active site 890402000542 pyrophosphate binding site [ion binding]; other site 890402000543 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 890402000544 ThiC-associated domain; Region: ThiC-associated; pfam13667 890402000545 ThiC family; Region: ThiC; pfam01964 890402000546 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 890402000547 substrate binding site [chemical binding]; other site 890402000548 multimerization interface [polypeptide binding]; other site 890402000549 ATP binding site [chemical binding]; other site 890402000550 glycyl-tRNA synthetase; Provisional; Region: PRK04173 890402000551 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 890402000552 motif 1; other site 890402000553 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 890402000554 active site 890402000555 motif 2; other site 890402000556 motif 3; other site 890402000557 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 890402000558 anticodon binding site; other site 890402000559 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 890402000560 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 890402000561 FMN binding site [chemical binding]; other site 890402000562 active site 890402000563 catalytic residues [active] 890402000564 substrate binding site [chemical binding]; other site 890402000565 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 890402000566 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 890402000567 nucleotide binding site [chemical binding]; other site 890402000568 SulA interaction site; other site 890402000569 Protein of unknown function (DUF552); Region: DUF552; pfam04472 890402000570 YGGT family; Region: YGGT; pfam02325 890402000571 DivIVA protein; Region: DivIVA; pfam05103 890402000572 DivIVA domain; Region: DivI1A_domain; TIGR03544 890402000573 lipoprotein signal peptidase; Provisional; Region: PRK14771 890402000574 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 890402000575 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 890402000576 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 890402000577 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 890402000578 active site 890402000579 PHP Thumb interface [polypeptide binding]; other site 890402000580 metal binding site [ion binding]; metal-binding site 890402000581 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 890402000582 generic binding surface II; other site 890402000583 generic binding surface I; other site 890402000584 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 890402000585 myosin-cross-reactive antigen; Provisional; Region: PRK13977 890402000586 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 890402000587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 890402000588 Coenzyme A binding pocket [chemical binding]; other site 890402000589 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 890402000590 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 890402000591 active site 890402000592 catalytic tetrad [active] 890402000593 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 890402000594 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 890402000595 nucleotide binding site [chemical binding]; other site 890402000596 Acylphosphatase; Region: Acylphosphatase; cl00551 890402000597 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 890402000598 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 890402000599 NAD binding site [chemical binding]; other site 890402000600 dimerization interface [polypeptide binding]; other site 890402000601 product binding site; other site 890402000602 substrate binding site [chemical binding]; other site 890402000603 zinc binding site [ion binding]; other site 890402000604 catalytic residues [active] 890402000605 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 890402000606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 890402000607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402000608 homodimer interface [polypeptide binding]; other site 890402000609 catalytic residue [active] 890402000610 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 890402000611 putative active site pocket [active] 890402000612 4-fold oligomerization interface [polypeptide binding]; other site 890402000613 metal binding residues [ion binding]; metal-binding site 890402000614 3-fold/trimer interface [polypeptide binding]; other site 890402000615 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 890402000616 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 890402000617 putative active site [active] 890402000618 oxyanion strand; other site 890402000619 catalytic triad [active] 890402000620 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 890402000621 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 890402000622 catalytic residues [active] 890402000623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 890402000624 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 890402000625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 890402000626 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 890402000627 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 890402000628 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 890402000629 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 890402000630 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 890402000631 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 890402000632 ATP binding site [chemical binding]; other site 890402000633 putative Mg++ binding site [ion binding]; other site 890402000634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 890402000635 nucleotide binding region [chemical binding]; other site 890402000636 ATP-binding site [chemical binding]; other site 890402000637 Helicase associated domain (HA2); Region: HA2; pfam04408 890402000638 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 890402000639 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 890402000640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 890402000641 S-adenosylmethionine binding site [chemical binding]; other site 890402000642 GTPases [General function prediction only]; Region: HflX; COG2262 890402000643 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 890402000644 HflX GTPase family; Region: HflX; cd01878 890402000645 G1 box; other site 890402000646 GTP/Mg2+ binding site [chemical binding]; other site 890402000647 Switch I region; other site 890402000648 G2 box; other site 890402000649 G3 box; other site 890402000650 Switch II region; other site 890402000651 G4 box; other site 890402000652 G5 box; other site 890402000653 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 890402000654 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 890402000655 NAD binding site [chemical binding]; other site 890402000656 dimer interface [polypeptide binding]; other site 890402000657 substrate binding site [chemical binding]; other site 890402000658 tetramer (dimer of dimers) interface [polypeptide binding]; other site 890402000659 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 890402000660 LexA repressor; Validated; Region: PRK00215 890402000661 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 890402000662 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 890402000663 Catalytic site [active] 890402000664 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 890402000665 ATP cone domain; Region: ATP-cone; pfam03477 890402000666 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 890402000667 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 890402000668 ligand binding site [chemical binding]; other site 890402000669 NAD binding site [chemical binding]; other site 890402000670 tetramer interface [polypeptide binding]; other site 890402000671 catalytic site [active] 890402000672 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 890402000673 L-serine binding site [chemical binding]; other site 890402000674 ACT domain interface; other site 890402000675 Part of AAA domain; Region: AAA_19; pfam13245 890402000676 Family description; Region: UvrD_C_2; pfam13538 890402000677 cell division protein MraZ; Reviewed; Region: PRK00326 890402000678 MraZ protein; Region: MraZ; pfam02381 890402000679 MraZ protein; Region: MraZ; pfam02381 890402000680 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 890402000681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 890402000682 S-adenosylmethionine binding site [chemical binding]; other site 890402000683 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 890402000684 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 890402000685 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 890402000686 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 890402000687 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 890402000688 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 890402000689 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 890402000690 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 890402000691 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 890402000692 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 890402000693 Mg++ binding site [ion binding]; other site 890402000694 putative catalytic motif [active] 890402000695 putative substrate binding site [chemical binding]; other site 890402000696 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 890402000697 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 890402000698 NAD binding site [chemical binding]; other site 890402000699 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 890402000700 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 890402000701 cell division protein FtsW; Region: ftsW; TIGR02614 890402000702 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 890402000703 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 890402000704 active site 890402000705 homodimer interface [polypeptide binding]; other site 890402000706 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 890402000707 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 890402000708 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 890402000709 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 890402000710 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 890402000711 Cell division protein FtsQ; Region: FtsQ; pfam03799 890402000712 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 890402000713 putative ADP-ribose binding site [chemical binding]; other site 890402000714 putative active site [active] 890402000715 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 890402000716 metal ion-dependent adhesion site (MIDAS); other site 890402000717 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 890402000718 putative active site [active] 890402000719 dimerization interface [polypeptide binding]; other site 890402000720 putative tRNAtyr binding site [nucleotide binding]; other site 890402000721 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 890402000722 active site 890402000723 catalytic site [active] 890402000724 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 890402000725 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 890402000726 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 890402000727 active site 890402000728 catalytic site [active] 890402000729 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 890402000730 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 890402000731 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 890402000732 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 890402000733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402000734 dimer interface [polypeptide binding]; other site 890402000735 conserved gate region; other site 890402000736 putative PBP binding loops; other site 890402000737 ABC-ATPase subunit interface; other site 890402000738 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 890402000739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402000740 dimer interface [polypeptide binding]; other site 890402000741 conserved gate region; other site 890402000742 putative PBP binding loops; other site 890402000743 ABC-ATPase subunit interface; other site 890402000744 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 890402000745 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 890402000746 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 890402000747 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 890402000748 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 890402000749 active site 890402000750 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 890402000751 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402000752 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402000753 DNA binding site [nucleotide binding] 890402000754 domain linker motif; other site 890402000755 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402000756 ligand binding site [chemical binding]; other site 890402000757 dimerization interface [polypeptide binding]; other site 890402000758 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 890402000759 putative active cleft [active] 890402000760 Uncharacterized conserved protein [Function unknown]; Region: COG3538 890402000761 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 890402000762 L-fucose transporter; Provisional; Region: PRK10133; cl17665 890402000763 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 890402000764 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 890402000765 active site 890402000766 metal binding site [ion binding]; metal-binding site 890402000767 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 890402000768 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 890402000769 putative substrate binding site [chemical binding]; other site 890402000770 putative ATP binding site [chemical binding]; other site 890402000771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 890402000772 putative DNA binding site [nucleotide binding]; other site 890402000773 Transcriptional regulators [Transcription]; Region: MarR; COG1846 890402000774 putative Zn2+ binding site [ion binding]; other site 890402000775 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 890402000776 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 890402000777 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 890402000778 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 890402000779 nucleotide binding site [chemical binding]; other site 890402000780 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 890402000781 non-specific DNA interactions [nucleotide binding]; other site 890402000782 DNA binding site [nucleotide binding] 890402000783 sequence specific DNA binding site [nucleotide binding]; other site 890402000784 putative cAMP binding site [chemical binding]; other site 890402000785 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 890402000786 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 890402000787 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 890402000788 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 890402000789 active site 890402000790 trimer interface [polypeptide binding]; other site 890402000791 allosteric site; other site 890402000792 active site lid [active] 890402000793 hexamer (dimer of trimers) interface [polypeptide binding]; other site 890402000794 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 890402000795 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 890402000796 active site 890402000797 dimer interface [polypeptide binding]; other site 890402000798 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 890402000799 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 890402000800 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 890402000801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402000802 dimer interface [polypeptide binding]; other site 890402000803 conserved gate region; other site 890402000804 putative PBP binding loops; other site 890402000805 ABC-ATPase subunit interface; other site 890402000806 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 890402000807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402000808 dimer interface [polypeptide binding]; other site 890402000809 conserved gate region; other site 890402000810 ABC-ATPase subunit interface; other site 890402000811 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 890402000812 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 890402000813 Walker A/P-loop; other site 890402000814 ATP binding site [chemical binding]; other site 890402000815 Q-loop/lid; other site 890402000816 ABC transporter signature motif; other site 890402000817 Walker B; other site 890402000818 D-loop; other site 890402000819 H-loop/switch region; other site 890402000820 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 890402000821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 890402000822 Walker A/P-loop; other site 890402000823 ATP binding site [chemical binding]; other site 890402000824 Q-loop/lid; other site 890402000825 ABC transporter signature motif; other site 890402000826 Walker B; other site 890402000827 D-loop; other site 890402000828 H-loop/switch region; other site 890402000829 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 890402000830 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 890402000831 nudix motif; other site 890402000832 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 890402000833 proline aminopeptidase P II; Provisional; Region: PRK10879 890402000834 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 890402000835 active site 890402000836 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 890402000837 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 890402000838 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 890402000839 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 890402000840 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 890402000841 Walker A/P-loop; other site 890402000842 ATP binding site [chemical binding]; other site 890402000843 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 890402000844 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 890402000845 ABC transporter signature motif; other site 890402000846 Walker B; other site 890402000847 D-loop; other site 890402000848 H-loop/switch region; other site 890402000849 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 890402000850 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 890402000851 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 890402000852 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 890402000853 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 890402000854 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 890402000855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 890402000856 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 890402000857 DNA binding residues [nucleotide binding] 890402000858 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 890402000859 active site 890402000860 catalytic residues [active] 890402000861 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 890402000862 active site 890402000863 catalytic residues [active] 890402000864 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 890402000865 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 890402000866 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 890402000867 putative deacylase active site [active] 890402000868 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 890402000869 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 890402000870 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 890402000871 Thiamine pyrophosphokinase; Region: TPK; cd07995 890402000872 active site 890402000873 dimerization interface [polypeptide binding]; other site 890402000874 thiamine binding site [chemical binding]; other site 890402000875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 890402000876 S-adenosylmethionine binding site [chemical binding]; other site 890402000877 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 890402000878 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 890402000879 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 890402000880 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 890402000881 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 890402000882 23S rRNA binding site [nucleotide binding]; other site 890402000883 L21 binding site [polypeptide binding]; other site 890402000884 L13 binding site [polypeptide binding]; other site 890402000885 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 890402000886 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 890402000887 active site 890402000888 Int/Topo IB signature motif; other site 890402000889 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 890402000890 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 890402000891 Walker A/P-loop; other site 890402000892 ATP binding site [chemical binding]; other site 890402000893 Q-loop/lid; other site 890402000894 ABC transporter signature motif; other site 890402000895 Walker B; other site 890402000896 D-loop; other site 890402000897 H-loop/switch region; other site 890402000898 FtsX-like permease family; Region: FtsX; pfam02687 890402000899 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 890402000900 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 890402000901 P-loop; other site 890402000902 Magnesium ion binding site [ion binding]; other site 890402000903 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 890402000904 Magnesium ion binding site [ion binding]; other site 890402000905 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 890402000906 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 890402000907 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 890402000908 nudix motif; other site 890402000909 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 890402000910 quinolinate synthetase; Provisional; Region: PRK09375 890402000911 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 890402000912 L-aspartate oxidase; Provisional; Region: PRK06175 890402000913 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 890402000914 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 890402000915 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 890402000916 dimerization interface [polypeptide binding]; other site 890402000917 active site 890402000918 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 890402000919 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 890402000920 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 890402000921 catalytic residue [active] 890402000922 benzoate transport; Region: 2A0115; TIGR00895 890402000923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402000924 putative substrate translocation pore; other site 890402000925 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 890402000926 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 890402000927 G1 box; other site 890402000928 putative GEF interaction site [polypeptide binding]; other site 890402000929 GTP/Mg2+ binding site [chemical binding]; other site 890402000930 Switch I region; other site 890402000931 G2 box; other site 890402000932 G3 box; other site 890402000933 Switch II region; other site 890402000934 G4 box; other site 890402000935 G5 box; other site 890402000936 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 890402000937 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 890402000938 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 890402000939 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 890402000940 Prephenate dehydratase; Region: PDT; pfam00800 890402000941 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 890402000942 putative L-Phe binding site [chemical binding]; other site 890402000943 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 890402000944 prephenate dehydrogenase; Validated; Region: PRK08507 890402000945 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 890402000946 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 890402000947 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 890402000948 active site 890402000949 DNA binding site [nucleotide binding] 890402000950 Int/Topo IB signature motif; other site 890402000951 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 890402000952 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 890402000953 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 890402000954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402000955 dimer interface [polypeptide binding]; other site 890402000956 conserved gate region; other site 890402000957 putative PBP binding loops; other site 890402000958 ABC-ATPase subunit interface; other site 890402000959 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 890402000960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402000961 dimer interface [polypeptide binding]; other site 890402000962 conserved gate region; other site 890402000963 putative PBP binding loops; other site 890402000964 ABC-ATPase subunit interface; other site 890402000965 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 890402000966 AAA domain; Region: AAA_21; pfam13304 890402000967 Walker A/P-loop; other site 890402000968 ATP binding site [chemical binding]; other site 890402000969 Q-loop/lid; other site 890402000970 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 890402000971 ABC transporter signature motif; other site 890402000972 Walker B; other site 890402000973 D-loop; other site 890402000974 H-loop/switch region; other site 890402000975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 890402000976 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 890402000977 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 890402000978 Walker A/P-loop; other site 890402000979 ATP binding site [chemical binding]; other site 890402000980 Q-loop/lid; other site 890402000981 ABC transporter signature motif; other site 890402000982 Walker B; other site 890402000983 D-loop; other site 890402000984 H-loop/switch region; other site 890402000985 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 890402000986 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 890402000987 putative active site [active] 890402000988 putative catalytic site [active] 890402000989 putative DNA binding site [nucleotide binding]; other site 890402000990 putative phosphate binding site [ion binding]; other site 890402000991 metal binding site A [ion binding]; metal-binding site 890402000992 putative AP binding site [nucleotide binding]; other site 890402000993 putative metal binding site B [ion binding]; other site 890402000994 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 890402000995 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 890402000996 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 890402000997 TRAM domain; Region: TRAM; cl01282 890402000998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 890402000999 S-adenosylmethionine binding site [chemical binding]; other site 890402001000 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 890402001001 aconitate hydratase; Validated; Region: PRK09277 890402001002 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 890402001003 substrate binding site [chemical binding]; other site 890402001004 ligand binding site [chemical binding]; other site 890402001005 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 890402001006 substrate binding site [chemical binding]; other site 890402001007 RelB antitoxin; Region: RelB; cl01171 890402001008 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 890402001009 putative active site [active] 890402001010 Protein of unknown function DUF262; Region: DUF262; pfam03235 890402001011 Uncharacterized conserved protein [Function unknown]; Region: COG1479 890402001012 Protein of unknown function DUF262; Region: DUF262; pfam03235 890402001013 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 890402001014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 890402001015 Coenzyme A binding pocket [chemical binding]; other site 890402001016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 890402001017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 890402001018 active site 890402001019 phosphorylation site [posttranslational modification] 890402001020 intermolecular recognition site; other site 890402001021 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 890402001022 DNA binding residues [nucleotide binding] 890402001023 dimerization interface [polypeptide binding]; other site 890402001024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 890402001025 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 890402001026 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 890402001027 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 890402001028 EamA-like transporter family; Region: EamA; pfam00892 890402001029 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 890402001030 synthetase active site [active] 890402001031 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 890402001032 NTP binding site [chemical binding]; other site 890402001033 metal binding site [ion binding]; metal-binding site 890402001034 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 890402001035 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 890402001036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 890402001037 FeS/SAM binding site; other site 890402001038 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 890402001039 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 890402001040 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 890402001041 Fic/DOC family; Region: Fic; cl00960 890402001042 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 890402001043 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 890402001044 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 890402001045 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 890402001046 Competence-damaged protein; Region: CinA; pfam02464 890402001047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 890402001048 sequence-specific DNA binding site [nucleotide binding]; other site 890402001049 salt bridge; other site 890402001050 recombinase A; Provisional; Region: recA; PRK09354 890402001051 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 890402001052 hexamer interface [polypeptide binding]; other site 890402001053 Walker A motif; other site 890402001054 ATP binding site [chemical binding]; other site 890402001055 Walker B motif; other site 890402001056 RecX family; Region: RecX; pfam02631 890402001057 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 890402001058 30S subunit binding site; other site 890402001059 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 890402001060 DEAD/DEAH box helicase; Region: DEAD; pfam00270 890402001061 ATP binding site [chemical binding]; other site 890402001062 putative Mg++ binding site [ion binding]; other site 890402001063 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 890402001064 SEC-C motif; Region: SEC-C; pfam02810 890402001065 Transposase; Region: DDE_Tnp_ISL3; pfam01610 890402001066 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 890402001067 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 890402001068 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 890402001069 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 890402001070 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 890402001071 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 890402001072 putative acyl-acceptor binding pocket; other site 890402001073 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 890402001074 Catalytic domain of Protein Kinases; Region: PKc; cd00180 890402001075 active site 890402001076 ATP binding site [chemical binding]; other site 890402001077 substrate binding site [chemical binding]; other site 890402001078 activation loop (A-loop); other site 890402001079 PASTA domain; Region: PASTA; pfam03793 890402001080 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 890402001081 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 890402001082 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 890402001083 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 890402001084 substrate binding pocket [chemical binding]; other site 890402001085 chain length determination region; other site 890402001086 substrate-Mg2+ binding site; other site 890402001087 catalytic residues [active] 890402001088 aspartate-rich region 1; other site 890402001089 active site lid residues [active] 890402001090 aspartate-rich region 2; other site 890402001091 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 890402001092 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 890402001093 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 890402001094 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 890402001095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 890402001096 DNA binding residues [nucleotide binding] 890402001097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 890402001098 Mg2+ binding site [ion binding]; other site 890402001099 G-X-G motif; other site 890402001100 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 890402001101 anchoring element; other site 890402001102 dimer interface [polypeptide binding]; other site 890402001103 ATP binding site [chemical binding]; other site 890402001104 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 890402001105 active site 890402001106 metal binding site [ion binding]; metal-binding site 890402001107 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 890402001108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402001109 Major Facilitator Superfamily; Region: MFS_1; pfam07690 890402001110 putative substrate translocation pore; other site 890402001111 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 890402001112 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 890402001113 substrate binding site [chemical binding]; other site 890402001114 dimer interface [polypeptide binding]; other site 890402001115 ATP binding site [chemical binding]; other site 890402001116 DEAD-like helicases superfamily; Region: DEXDc; smart00487 890402001117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 890402001118 ATP binding site [chemical binding]; other site 890402001119 putative Mg++ binding site [ion binding]; other site 890402001120 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 890402001121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 890402001122 nucleotide binding region [chemical binding]; other site 890402001123 ATP-binding site [chemical binding]; other site 890402001124 DEAD/H associated; Region: DEAD_assoc; pfam08494 890402001125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 890402001126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 890402001127 phosphorylation site [posttranslational modification] 890402001128 intermolecular recognition site; other site 890402001129 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 890402001130 DNA binding site [nucleotide binding] 890402001131 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 890402001132 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 890402001133 CAP-like domain; other site 890402001134 active site 890402001135 primary dimer interface [polypeptide binding]; other site 890402001136 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 890402001137 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 890402001138 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 890402001139 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 890402001140 trimer interface [polypeptide binding]; other site 890402001141 active site 890402001142 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 890402001143 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 890402001144 Zn2+ binding site [ion binding]; other site 890402001145 Mg2+ binding site [ion binding]; other site 890402001146 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 890402001147 synthetase active site [active] 890402001148 NTP binding site [chemical binding]; other site 890402001149 metal binding site [ion binding]; metal-binding site 890402001150 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 890402001151 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 890402001152 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 890402001153 active site 890402001154 HipA-like C-terminal domain; Region: HipA_C; pfam07804 890402001155 Fic family protein [Function unknown]; Region: COG3177 890402001156 Fic/DOC family; Region: Fic; pfam02661 890402001157 Abi-like protein; Region: Abi_2; cl01988 890402001158 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 890402001159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 890402001160 DNA-binding interface [nucleotide binding]; DNA binding site 890402001161 Integrase core domain; Region: rve; pfam00665 890402001162 transposase/IS protein; Provisional; Region: PRK09183 890402001163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402001164 Walker A motif; other site 890402001165 ATP binding site [chemical binding]; other site 890402001166 Walker B motif; other site 890402001167 Abi-like protein; Region: Abi_2; pfam07751 890402001168 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 890402001169 Integrase core domain; Region: rve; pfam00665 890402001170 Helix-turn-helix domain; Region: HTH_38; pfam13936 890402001171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402001172 Transposase, Mutator family; Region: Transposase_mut; pfam00872 890402001173 MULE transposase domain; Region: MULE; pfam10551 890402001174 EamA-like transporter family; Region: EamA; pfam00892 890402001175 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 890402001176 EamA-like transporter family; Region: EamA; pfam00892 890402001177 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 890402001178 Methyltransferase domain; Region: Methyltransf_26; pfam13659 890402001179 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 890402001180 catalytic core [active] 890402001181 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 890402001182 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 890402001183 Cl binding site [ion binding]; other site 890402001184 oligomer interface [polypeptide binding]; other site 890402001185 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 890402001186 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 890402001187 substrate binding pocket [chemical binding]; other site 890402001188 membrane-bound complex binding site; other site 890402001189 hinge residues; other site 890402001190 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495 890402001191 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 890402001192 active site 890402001193 HIGH motif; other site 890402001194 nucleotide binding site [chemical binding]; other site 890402001195 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 890402001196 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 890402001197 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 890402001198 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 890402001199 active site 890402001200 KMSKS motif; other site 890402001201 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 890402001202 tRNA binding surface [nucleotide binding]; other site 890402001203 Helix-hairpin-helix motif; Region: HHH; pfam00633 890402001204 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 890402001205 Competence protein; Region: Competence; pfam03772 890402001206 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 890402001207 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 890402001208 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 890402001209 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 890402001210 active site 890402001211 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 890402001212 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 890402001213 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 890402001214 Glycoprotease family; Region: Peptidase_M22; pfam00814 890402001215 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 890402001216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 890402001217 Coenzyme A binding pocket [chemical binding]; other site 890402001218 UGMP family protein; Validated; Region: PRK09604 890402001219 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 890402001220 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 890402001221 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 890402001222 isocitrate dehydrogenase; Validated; Region: PRK08299 890402001223 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 890402001224 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 890402001225 active site 890402001226 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 890402001227 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 890402001228 acyl-activating enzyme (AAE) consensus motif; other site 890402001229 putative AMP binding site [chemical binding]; other site 890402001230 putative active site [active] 890402001231 putative CoA binding site [chemical binding]; other site 890402001232 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 890402001233 active site 890402001234 catalytic residues [active] 890402001235 metal binding site [ion binding]; metal-binding site 890402001236 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 890402001237 rRNA interaction site [nucleotide binding]; other site 890402001238 S8 interaction site; other site 890402001239 putative laminin-1 binding site; other site 890402001240 elongation factor Ts; Provisional; Region: tsf; PRK09377 890402001241 Elongation factor TS; Region: EF_TS; pfam00889 890402001242 Elongation factor TS; Region: EF_TS; pfam00889 890402001243 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 890402001244 putative nucleotide binding site [chemical binding]; other site 890402001245 uridine monophosphate binding site [chemical binding]; other site 890402001246 homohexameric interface [polypeptide binding]; other site 890402001247 ribosome recycling factor; Reviewed; Region: frr; PRK00083 890402001248 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 890402001249 hinge region; other site 890402001250 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 890402001251 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 890402001252 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 890402001253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 890402001254 FeS/SAM binding site; other site 890402001255 intracellular protease, PfpI family; Region: PfpI; TIGR01382 890402001256 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 890402001257 proposed catalytic triad [active] 890402001258 conserved cys residue [active] 890402001259 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 890402001260 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 890402001261 substrate binding site [chemical binding]; other site 890402001262 glutamase interaction surface [polypeptide binding]; other site 890402001263 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 890402001264 anthranilate synthase component I; Provisional; Region: PRK13571 890402001265 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 890402001266 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 890402001267 Protein of unknown function (DUF969); Region: DUF969; cl01573 890402001268 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 890402001269 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 890402001270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402001271 Walker A/P-loop; other site 890402001272 ATP binding site [chemical binding]; other site 890402001273 Q-loop/lid; other site 890402001274 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 890402001275 ABC transporter signature motif; other site 890402001276 Walker B; other site 890402001277 D-loop; other site 890402001278 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 890402001279 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 890402001280 classical (c) SDRs; Region: SDR_c; cd05233 890402001281 NAD(P) binding site [chemical binding]; other site 890402001282 active site 890402001283 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 890402001284 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 890402001285 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 890402001286 Walker A/P-loop; other site 890402001287 ATP binding site [chemical binding]; other site 890402001288 Q-loop/lid; other site 890402001289 ABC transporter signature motif; other site 890402001290 Walker B; other site 890402001291 D-loop; other site 890402001292 H-loop/switch region; other site 890402001293 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 890402001294 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 890402001295 Walker A/P-loop; other site 890402001296 ATP binding site [chemical binding]; other site 890402001297 Q-loop/lid; other site 890402001298 ABC transporter signature motif; other site 890402001299 Walker B; other site 890402001300 D-loop; other site 890402001301 H-loop/switch region; other site 890402001302 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 890402001303 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 890402001304 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 890402001305 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 890402001306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 890402001307 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 890402001308 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 890402001309 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 890402001310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 890402001311 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 890402001312 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 890402001313 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 890402001314 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 890402001315 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 890402001316 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 890402001317 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 890402001318 GIY-YIG motif/motif A; other site 890402001319 active site 890402001320 catalytic site [active] 890402001321 putative DNA binding site [nucleotide binding]; other site 890402001322 metal binding site [ion binding]; metal-binding site 890402001323 UvrB/uvrC motif; Region: UVR; pfam02151 890402001324 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 890402001325 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 890402001326 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 890402001327 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 890402001328 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 890402001329 shikimate binding site; other site 890402001330 NAD(P) binding site [chemical binding]; other site 890402001331 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 890402001332 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 890402001333 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 890402001334 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 890402001335 Phosphoglycerate kinase; Region: PGK; pfam00162 890402001336 substrate binding site [chemical binding]; other site 890402001337 hinge regions; other site 890402001338 ADP binding site [chemical binding]; other site 890402001339 catalytic site [active] 890402001340 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 890402001341 triosephosphate isomerase; Provisional; Region: PRK14567 890402001342 substrate binding site [chemical binding]; other site 890402001343 dimer interface [polypeptide binding]; other site 890402001344 catalytic triad [active] 890402001345 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 890402001346 tetramer (dimer of dimers) interface [polypeptide binding]; other site 890402001347 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 890402001348 NAD binding site [chemical binding]; other site 890402001349 dimer interface [polypeptide binding]; other site 890402001350 substrate binding site [chemical binding]; other site 890402001351 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 890402001352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 890402001353 active site 890402001354 motif I; other site 890402001355 motif II; other site 890402001356 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 890402001357 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 890402001358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 890402001359 non-specific DNA binding site [nucleotide binding]; other site 890402001360 salt bridge; other site 890402001361 sequence-specific DNA binding site [nucleotide binding]; other site 890402001362 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 890402001363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402001364 homodimer interface [polypeptide binding]; other site 890402001365 catalytic residue [active] 890402001366 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 890402001367 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 890402001368 putative active site [active] 890402001369 transaldolase; Provisional; Region: PRK03903 890402001370 catalytic residue [active] 890402001371 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 890402001372 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 890402001373 TPP-binding site [chemical binding]; other site 890402001374 dimer interface [polypeptide binding]; other site 890402001375 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 890402001376 PYR/PP interface [polypeptide binding]; other site 890402001377 dimer interface [polypeptide binding]; other site 890402001378 TPP binding site [chemical binding]; other site 890402001379 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 890402001380 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 890402001381 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 890402001382 chaperone protein DnaJ; Provisional; Region: PRK14278 890402001383 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 890402001384 HSP70 interaction site [polypeptide binding]; other site 890402001385 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 890402001386 Zn binding sites [ion binding]; other site 890402001387 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 890402001388 dimer interface [polypeptide binding]; other site 890402001389 Fructosamine kinase; Region: Fructosamin_kin; cl17579 890402001390 Phosphotransferase enzyme family; Region: APH; pfam01636 890402001391 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 890402001392 PAC2 family; Region: PAC2; pfam09754 890402001393 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 890402001394 thiS-thiF/thiG interaction site; other site 890402001395 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 890402001396 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 890402001397 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 890402001398 active site 890402001399 dimer interface [polypeptide binding]; other site 890402001400 motif 1; other site 890402001401 motif 2; other site 890402001402 motif 3; other site 890402001403 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 890402001404 anticodon binding site; other site 890402001405 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 890402001406 nucleotide binding site/active site [active] 890402001407 HIT family signature motif; other site 890402001408 catalytic residue [active] 890402001409 hypothetical protein; Validated; Region: PRK00110 890402001410 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 890402001411 active site 890402001412 putative DNA-binding cleft [nucleotide binding]; other site 890402001413 dimer interface [polypeptide binding]; other site 890402001414 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 890402001415 RuvA N terminal domain; Region: RuvA_N; pfam01330 890402001416 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 890402001417 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 890402001418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402001419 Walker A motif; other site 890402001420 ATP binding site [chemical binding]; other site 890402001421 Walker B motif; other site 890402001422 arginine finger; other site 890402001423 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 890402001424 Preprotein translocase subunit; Region: YajC; pfam02699 890402001425 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 890402001426 active site 890402001427 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 890402001428 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 890402001429 CoA-ligase; Region: Ligase_CoA; pfam00549 890402001430 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 890402001431 CoA binding domain; Region: CoA_binding; smart00881 890402001432 CoA-ligase; Region: Ligase_CoA; pfam00549 890402001433 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 890402001434 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 890402001435 purine monophosphate binding site [chemical binding]; other site 890402001436 dimer interface [polypeptide binding]; other site 890402001437 putative catalytic residues [active] 890402001438 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 890402001439 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 890402001440 amphipathic channel; other site 890402001441 Asn-Pro-Ala signature motifs; other site 890402001442 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 890402001443 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 890402001444 RNA binding surface [nucleotide binding]; other site 890402001445 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 890402001446 active site 890402001447 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 890402001448 AAA domain; Region: AAA_17; pfam13207 890402001449 Cytidylate kinase; Region: Cytidylate_kin; pfam02224 890402001450 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 890402001451 G1 box; other site 890402001452 GTP/Mg2+ binding site [chemical binding]; other site 890402001453 Switch I region; other site 890402001454 G2 box; other site 890402001455 Switch II region; other site 890402001456 G3 box; other site 890402001457 G4 box; other site 890402001458 G5 box; other site 890402001459 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 890402001460 G1 box; other site 890402001461 GTP/Mg2+ binding site [chemical binding]; other site 890402001462 Switch I region; other site 890402001463 G2 box; other site 890402001464 G3 box; other site 890402001465 Switch II region; other site 890402001466 G4 box; other site 890402001467 G5 box; other site 890402001468 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 890402001469 active site 890402001470 Predicted transcriptional regulator [Transcription]; Region: COG2378 890402001471 WYL domain; Region: WYL; pfam13280 890402001472 DEAD-like helicases superfamily; Region: DEXDc; smart00487 890402001473 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 890402001474 ATP binding site [chemical binding]; other site 890402001475 putative Mg++ binding site [ion binding]; other site 890402001476 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 890402001477 nucleotide binding region [chemical binding]; other site 890402001478 ATP-binding site [chemical binding]; other site 890402001479 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 890402001480 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 890402001481 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 890402001482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 890402001483 motif II; other site 890402001484 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 890402001485 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 890402001486 active site 890402001487 catalytic residues [active] 890402001488 DNA binding site [nucleotide binding] 890402001489 Int/Topo IB signature motif; other site 890402001490 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 890402001491 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 890402001492 active site 890402001493 catalytic site [active] 890402001494 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 890402001495 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 890402001496 catalytic residues [active] 890402001497 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 890402001498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 890402001499 active site 890402001500 phosphorylation site [posttranslational modification] 890402001501 intermolecular recognition site; other site 890402001502 dimerization interface [polypeptide binding]; other site 890402001503 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 890402001504 DNA binding site [nucleotide binding] 890402001505 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 890402001506 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 890402001507 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 890402001508 Ligand Binding Site [chemical binding]; other site 890402001509 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 890402001510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 890402001511 dimer interface [polypeptide binding]; other site 890402001512 phosphorylation site [posttranslational modification] 890402001513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 890402001514 ATP binding site [chemical binding]; other site 890402001515 Mg2+ binding site [ion binding]; other site 890402001516 G-X-G motif; other site 890402001517 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 890402001518 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 890402001519 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 890402001520 Soluble P-type ATPase [General function prediction only]; Region: COG4087 890402001521 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 890402001522 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 890402001523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 890402001524 DNA-binding interface [nucleotide binding]; DNA binding site 890402001525 Integrase core domain; Region: rve; pfam00665 890402001526 transposase/IS protein; Provisional; Region: PRK09183 890402001527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402001528 Walker A motif; other site 890402001529 ATP binding site [chemical binding]; other site 890402001530 Walker B motif; other site 890402001531 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 890402001532 DNA binding residues [nucleotide binding] 890402001533 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 890402001534 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 890402001535 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 890402001536 phosphopeptide binding site; other site 890402001537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 890402001538 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 890402001539 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 890402001540 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 890402001541 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 890402001542 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 890402001543 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 890402001544 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 890402001545 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 890402001546 homodimer interface [polypeptide binding]; other site 890402001547 putative metal binding site [ion binding]; other site 890402001548 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 890402001549 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 890402001550 substrate binding site [chemical binding]; other site 890402001551 hexamer interface [polypeptide binding]; other site 890402001552 metal binding site [ion binding]; metal-binding site 890402001553 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 890402001554 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 890402001555 substrate binding site [chemical binding]; other site 890402001556 active site 890402001557 catalytic residues [active] 890402001558 heterodimer interface [polypeptide binding]; other site 890402001559 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 890402001560 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 890402001561 active site 890402001562 ribulose/triose binding site [chemical binding]; other site 890402001563 phosphate binding site [ion binding]; other site 890402001564 substrate (anthranilate) binding pocket [chemical binding]; other site 890402001565 product (indole) binding pocket [chemical binding]; other site 890402001566 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 890402001567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402001568 catalytic residue [active] 890402001569 endonuclease IV; Provisional; Region: PRK01060 890402001570 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 890402001571 AP (apurinic/apyrimidinic) site pocket; other site 890402001572 DNA interaction; other site 890402001573 Metal-binding active site; metal-binding site 890402001574 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 890402001575 VanZ like family; Region: VanZ; pfam04892 890402001576 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 890402001577 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 890402001578 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 890402001579 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 890402001580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 890402001581 Coenzyme A binding pocket [chemical binding]; other site 890402001582 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 890402001583 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 890402001584 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 890402001585 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 890402001586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 890402001587 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 890402001588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402001589 Walker A/P-loop; other site 890402001590 ATP binding site [chemical binding]; other site 890402001591 Q-loop/lid; other site 890402001592 ABC transporter signature motif; other site 890402001593 Walker B; other site 890402001594 D-loop; other site 890402001595 H-loop/switch region; other site 890402001596 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 890402001597 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 890402001598 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 890402001599 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 890402001600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402001601 Walker A/P-loop; other site 890402001602 ATP binding site [chemical binding]; other site 890402001603 Q-loop/lid; other site 890402001604 ABC transporter signature motif; other site 890402001605 Walker B; other site 890402001606 D-loop; other site 890402001607 H-loop/switch region; other site 890402001608 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 890402001609 Integrase core domain; Region: rve; pfam00665 890402001610 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 890402001611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 890402001612 active site 890402001613 phosphorylation site [posttranslational modification] 890402001614 intermolecular recognition site; other site 890402001615 dimerization interface [polypeptide binding]; other site 890402001616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 890402001617 DNA binding residues [nucleotide binding] 890402001618 dimerization interface [polypeptide binding]; other site 890402001619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 890402001620 Histidine kinase; Region: HisKA_3; pfam07730 890402001621 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 890402001622 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 890402001623 AAA domain; Region: AAA_21; pfam13304 890402001624 Walker A/P-loop; other site 890402001625 ATP binding site [chemical binding]; other site 890402001626 ABC transporter; Region: ABC_tran; pfam00005 890402001627 Q-loop/lid; other site 890402001628 ABC transporter signature motif; other site 890402001629 Walker B; other site 890402001630 D-loop; other site 890402001631 H-loop/switch region; other site 890402001632 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 890402001633 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 890402001634 Predicted amidohydrolase [General function prediction only]; Region: COG0388 890402001635 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 890402001636 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 890402001637 nudix motif; other site 890402001638 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 890402001639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402001640 Major Facilitator Superfamily; Region: MFS_1; pfam07690 890402001641 S-methylmethionine transporter; Provisional; Region: PRK11387 890402001642 Spore germination protein; Region: Spore_permease; cl17796 890402001643 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 890402001644 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 890402001645 Catalytic site [active] 890402001646 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 890402001647 Fic/DOC family; Region: Fic; pfam02661 890402001648 Uncharacterized conserved protein [Function unknown]; Region: COG3189 890402001649 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 890402001650 aspartate aminotransferase; Provisional; Region: PRK06836 890402001651 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 890402001652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402001653 homodimer interface [polypeptide binding]; other site 890402001654 catalytic residue [active] 890402001655 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 890402001656 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 890402001657 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 890402001658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 890402001659 motif II; other site 890402001660 Transcriptional regulator [Transcription]; Region: LysR; COG0583 890402001661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 890402001662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 890402001663 dimerization interface [polypeptide binding]; other site 890402001664 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 890402001665 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 890402001666 active site 890402001667 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 890402001668 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 890402001669 heterodimer interface [polypeptide binding]; other site 890402001670 active site 890402001671 FMN binding site [chemical binding]; other site 890402001672 homodimer interface [polypeptide binding]; other site 890402001673 substrate binding site [chemical binding]; other site 890402001674 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 890402001675 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 890402001676 FAD binding pocket [chemical binding]; other site 890402001677 FAD binding motif [chemical binding]; other site 890402001678 phosphate binding motif [ion binding]; other site 890402001679 beta-alpha-beta structure motif; other site 890402001680 NAD binding pocket [chemical binding]; other site 890402001681 Iron coordination center [ion binding]; other site 890402001682 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 890402001683 active site 890402001684 dimer interface [polypeptide binding]; other site 890402001685 dihydroorotase; Validated; Region: pyrC; PRK09357 890402001686 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 890402001687 active site 890402001688 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 890402001689 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 890402001690 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 890402001691 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 890402001692 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 890402001693 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 890402001694 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 890402001695 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 890402001696 metal binding triad; other site 890402001697 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 890402001698 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 890402001699 metal binding triad; other site 890402001700 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 890402001701 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 890402001702 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 890402001703 active site 890402001704 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 890402001705 FAD binding site [chemical binding]; other site 890402001706 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 890402001707 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 890402001708 THF binding site; other site 890402001709 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 890402001710 substrate binding site [chemical binding]; other site 890402001711 THF binding site; other site 890402001712 zinc-binding site [ion binding]; other site 890402001713 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 890402001714 catalytic core [active] 890402001715 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 890402001716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 890402001717 S-adenosylmethionine binding site [chemical binding]; other site 890402001718 Predicted esterase [General function prediction only]; Region: COG0400 890402001719 putative hydrolase; Provisional; Region: PRK11460 890402001720 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 890402001721 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 890402001722 active site 890402001723 catalytic tetrad [active] 890402001724 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 890402001725 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 890402001726 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 890402001727 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 890402001728 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 890402001729 active site 890402001730 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 890402001731 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 890402001732 EcoRII C terminal; Region: EcoRII-C; pfam09019 890402001733 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 890402001734 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 890402001735 cofactor binding site; other site 890402001736 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 890402001737 DNA binding site [nucleotide binding] 890402001738 substrate interaction site [chemical binding]; other site 890402001739 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 890402001740 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 890402001741 putative active site [active] 890402001742 Domain of unknown function (DUF955); Region: DUF955; cl01076 890402001743 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 890402001744 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 890402001745 catalytic triad [active] 890402001746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 890402001747 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 890402001748 active site 890402001749 motif I; other site 890402001750 motif II; other site 890402001751 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 890402001752 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 890402001753 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 890402001754 Walker A/P-loop; other site 890402001755 ATP binding site [chemical binding]; other site 890402001756 Q-loop/lid; other site 890402001757 ABC transporter signature motif; other site 890402001758 Walker B; other site 890402001759 D-loop; other site 890402001760 H-loop/switch region; other site 890402001761 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 890402001762 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 890402001763 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 890402001764 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 890402001765 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 890402001766 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 890402001767 active site 890402001768 dimer interface [polypeptide binding]; other site 890402001769 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 890402001770 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 890402001771 active site 890402001772 FMN binding site [chemical binding]; other site 890402001773 substrate binding site [chemical binding]; other site 890402001774 3Fe-4S cluster binding site [ion binding]; other site 890402001775 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 890402001776 domain interface; other site 890402001777 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402001778 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402001779 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 890402001780 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 890402001781 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402001782 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402001783 DNA binding site [nucleotide binding] 890402001784 domain linker motif; other site 890402001785 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 890402001786 ligand binding site [chemical binding]; other site 890402001787 dimerization interface (open form) [polypeptide binding]; other site 890402001788 dimerization interface (closed form) [polypeptide binding]; other site 890402001789 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 890402001790 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 890402001791 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 890402001792 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 890402001793 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 890402001794 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402001795 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402001796 DNA binding site [nucleotide binding] 890402001797 domain linker motif; other site 890402001798 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402001799 dimerization interface [polypeptide binding]; other site 890402001800 ligand binding site [chemical binding]; other site 890402001801 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 890402001802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 890402001803 FeS/SAM binding site; other site 890402001804 HemN C-terminal domain; Region: HemN_C; pfam06969 890402001805 GTP-binding protein LepA; Provisional; Region: PRK05433 890402001806 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 890402001807 G1 box; other site 890402001808 putative GEF interaction site [polypeptide binding]; other site 890402001809 GTP/Mg2+ binding site [chemical binding]; other site 890402001810 Switch I region; other site 890402001811 G2 box; other site 890402001812 G3 box; other site 890402001813 Switch II region; other site 890402001814 G4 box; other site 890402001815 G5 box; other site 890402001816 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 890402001817 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 890402001818 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 890402001819 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 890402001820 UPF0126 domain; Region: UPF0126; pfam03458 890402001821 Predicted membrane protein [Function unknown]; Region: COG2860 890402001822 UPF0126 domain; Region: UPF0126; pfam03458 890402001823 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 890402001824 homodimer interface [polypeptide binding]; other site 890402001825 MazG family protein; Region: mazG; TIGR00444 890402001826 metal binding site [ion binding]; metal-binding site 890402001827 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 890402001828 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 890402001829 homodimer interface [polypeptide binding]; other site 890402001830 substrate-cofactor binding pocket; other site 890402001831 catalytic residue [active] 890402001832 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 890402001833 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 890402001834 5S rRNA interface [nucleotide binding]; other site 890402001835 CTC domain interface [polypeptide binding]; other site 890402001836 L16 interface [polypeptide binding]; other site 890402001837 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 890402001838 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 890402001839 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 890402001840 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 890402001841 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 890402001842 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 890402001843 ligand binding site [chemical binding]; other site 890402001844 homodimer interface [polypeptide binding]; other site 890402001845 NAD(P) binding site [chemical binding]; other site 890402001846 trimer interface B [polypeptide binding]; other site 890402001847 trimer interface A [polypeptide binding]; other site 890402001848 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 890402001849 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 890402001850 acyl-activating enzyme (AAE) consensus motif; other site 890402001851 putative AMP binding site [chemical binding]; other site 890402001852 putative active site [active] 890402001853 putative CoA binding site [chemical binding]; other site 890402001854 GTPase Era; Reviewed; Region: era; PRK00089 890402001855 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 890402001856 G1 box; other site 890402001857 GTP/Mg2+ binding site [chemical binding]; other site 890402001858 Switch I region; other site 890402001859 G2 box; other site 890402001860 Switch II region; other site 890402001861 G3 box; other site 890402001862 G4 box; other site 890402001863 G5 box; other site 890402001864 KH domain; Region: KH_2; pfam07650 890402001865 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 890402001866 Domain of unknown function DUF21; Region: DUF21; pfam01595 890402001867 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 890402001868 Transporter associated domain; Region: CorC_HlyC; smart01091 890402001869 metal-binding heat shock protein; Provisional; Region: PRK00016 890402001870 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 890402001871 PhoH-like protein; Region: PhoH; pfam02562 890402001872 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 890402001873 nucleotide binding site/active site [active] 890402001874 HIT family signature motif; other site 890402001875 catalytic residue [active] 890402001876 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 890402001877 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 890402001878 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 890402001879 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 890402001880 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 890402001881 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 890402001882 ligand binding site; other site 890402001883 oligomer interface; other site 890402001884 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 890402001885 dimer interface [polypeptide binding]; other site 890402001886 N-terminal domain interface [polypeptide binding]; other site 890402001887 sulfate 1 binding site; other site 890402001888 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 890402001889 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 890402001890 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 890402001891 trimerization site [polypeptide binding]; other site 890402001892 active site 890402001893 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 890402001894 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 890402001895 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 890402001896 catalytic residue [active] 890402001897 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 890402001898 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 890402001899 Walker A/P-loop; other site 890402001900 ATP binding site [chemical binding]; other site 890402001901 Q-loop/lid; other site 890402001902 ABC transporter signature motif; other site 890402001903 Walker B; other site 890402001904 D-loop; other site 890402001905 H-loop/switch region; other site 890402001906 FeS assembly protein SufD; Region: sufD; TIGR01981 890402001907 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 890402001908 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 890402001909 FeS assembly protein SufB; Region: sufB; TIGR01980 890402001910 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 890402001911 CTP synthetase; Validated; Region: pyrG; PRK05380 890402001912 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 890402001913 Catalytic site [active] 890402001914 active site 890402001915 UTP binding site [chemical binding]; other site 890402001916 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 890402001917 active site 890402001918 putative oxyanion hole; other site 890402001919 catalytic triad [active] 890402001920 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 890402001921 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 890402001922 metal binding site [ion binding]; metal-binding site 890402001923 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 890402001924 Dehydroquinase class II; Region: DHquinase_II; pfam01220 890402001925 trimer interface [polypeptide binding]; other site 890402001926 active site 890402001927 dimer interface [polypeptide binding]; other site 890402001928 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 890402001929 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 890402001930 ADP binding site [chemical binding]; other site 890402001931 magnesium binding site [ion binding]; other site 890402001932 putative shikimate binding site; other site 890402001933 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 890402001934 active site 890402001935 dimer interface [polypeptide binding]; other site 890402001936 metal binding site [ion binding]; metal-binding site 890402001937 YceG-like family; Region: YceG; pfam02618 890402001938 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 890402001939 dimerization interface [polypeptide binding]; other site 890402001940 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 890402001941 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 890402001942 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 890402001943 motif 1; other site 890402001944 active site 890402001945 motif 2; other site 890402001946 motif 3; other site 890402001947 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 890402001948 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 890402001949 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 890402001950 catalytic core [active] 890402001951 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 890402001952 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 890402001953 catalytic triad [active] 890402001954 catalytic triad [active] 890402001955 oxyanion hole [active] 890402001956 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 890402001957 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 890402001958 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 890402001959 RNA binding surface [nucleotide binding]; other site 890402001960 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 890402001961 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 890402001962 Walker A/P-loop; other site 890402001963 ATP binding site [chemical binding]; other site 890402001964 Q-loop/lid; other site 890402001965 ABC transporter signature motif; other site 890402001966 Walker B; other site 890402001967 D-loop; other site 890402001968 H-loop/switch region; other site 890402001969 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 890402001970 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 890402001971 FtsX-like permease family; Region: FtsX; pfam02687 890402001972 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 890402001973 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 890402001974 Part of AAA domain; Region: AAA_19; pfam13245 890402001975 Family description; Region: UvrD_C_2; pfam13538 890402001976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 890402001977 active site 890402001978 xanthine permease; Region: pbuX; TIGR03173 890402001979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 890402001980 salt bridge; other site 890402001981 non-specific DNA binding site [nucleotide binding]; other site 890402001982 sequence-specific DNA binding site [nucleotide binding]; other site 890402001983 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 890402001984 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 890402001985 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 890402001986 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 890402001987 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 890402001988 Isochorismatase family; Region: Isochorismatase; pfam00857 890402001989 catalytic triad [active] 890402001990 metal binding site [ion binding]; metal-binding site 890402001991 conserved cis-peptide bond; other site 890402001992 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 890402001993 Divergent AAA domain; Region: AAA_4; pfam04326 890402001994 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 890402001995 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 890402001996 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 890402001997 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 890402001998 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 890402001999 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 890402002000 Walker A/P-loop; other site 890402002001 ATP binding site [chemical binding]; other site 890402002002 Q-loop/lid; other site 890402002003 ABC transporter signature motif; other site 890402002004 Walker B; other site 890402002005 D-loop; other site 890402002006 H-loop/switch region; other site 890402002007 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 890402002008 Histidine kinase; Region: HisKA_3; pfam07730 890402002009 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 890402002010 ATP binding site [chemical binding]; other site 890402002011 Mg2+ binding site [ion binding]; other site 890402002012 G-X-G motif; other site 890402002013 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 890402002014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 890402002015 active site 890402002016 phosphorylation site [posttranslational modification] 890402002017 intermolecular recognition site; other site 890402002018 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 890402002019 DNA binding residues [nucleotide binding] 890402002020 dimerization interface [polypeptide binding]; other site 890402002021 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 890402002022 Phosphate transporter family; Region: PHO4; pfam01384 890402002023 Protein of unknown function (DUF466); Region: DUF466; cl01082 890402002024 carbon starvation protein A; Provisional; Region: PRK15015 890402002025 Carbon starvation protein CstA; Region: CstA; pfam02554 890402002026 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 890402002027 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 890402002028 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 890402002029 active site 890402002030 catalytic site [active] 890402002031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 890402002032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 890402002033 WHG domain; Region: WHG; pfam13305 890402002034 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 890402002035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 890402002036 ATP binding site [chemical binding]; other site 890402002037 putative Mg++ binding site [ion binding]; other site 890402002038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 890402002039 nucleotide binding region [chemical binding]; other site 890402002040 ATP-binding site [chemical binding]; other site 890402002041 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 890402002042 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 890402002043 catalytic core [active] 890402002044 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 890402002045 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 890402002046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 890402002047 non-specific DNA binding site [nucleotide binding]; other site 890402002048 salt bridge; other site 890402002049 sequence-specific DNA binding site [nucleotide binding]; other site 890402002050 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 890402002051 Short C-terminal domain; Region: SHOCT; pfam09851 890402002052 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 890402002053 Protein kinase domain; Region: Pkinase; pfam00069 890402002054 Catalytic domain of Protein Kinases; Region: PKc; cd00180 890402002055 active site 890402002056 ATP binding site [chemical binding]; other site 890402002057 substrate binding site [chemical binding]; other site 890402002058 activation loop (A-loop); other site 890402002059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402002060 H+ Antiporter protein; Region: 2A0121; TIGR00900 890402002061 putative substrate translocation pore; other site 890402002062 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 890402002063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402002064 putative substrate translocation pore; other site 890402002065 FOG: CBS domain [General function prediction only]; Region: COG0517 890402002066 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 890402002067 hypothetical protein; Provisional; Region: PRK11770 890402002068 Domain of unknown function (DUF307); Region: DUF307; pfam03733 890402002069 Domain of unknown function (DUF307); Region: DUF307; pfam03733 890402002070 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 890402002071 active site 890402002072 metal binding site [ion binding]; metal-binding site 890402002073 hypothetical protein; Provisional; Region: PRK06762 890402002074 AAA domain; Region: AAA_33; pfam13671 890402002075 RNA ligase; Region: RNA_lig_T4_1; pfam09511 890402002076 GTP-binding protein YchF; Reviewed; Region: PRK09601 890402002077 YchF GTPase; Region: YchF; cd01900 890402002078 G1 box; other site 890402002079 GTP/Mg2+ binding site [chemical binding]; other site 890402002080 Switch I region; other site 890402002081 G2 box; other site 890402002082 Switch II region; other site 890402002083 G3 box; other site 890402002084 G4 box; other site 890402002085 G5 box; other site 890402002086 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 890402002087 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 890402002088 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 890402002089 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 890402002090 Histidine kinase; Region: HisKA_3; pfam07730 890402002091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 890402002092 ATP binding site [chemical binding]; other site 890402002093 Mg2+ binding site [ion binding]; other site 890402002094 G-X-G motif; other site 890402002095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 890402002096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 890402002097 active site 890402002098 phosphorylation site [posttranslational modification] 890402002099 intermolecular recognition site; other site 890402002100 dimerization interface [polypeptide binding]; other site 890402002101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 890402002102 DNA binding residues [nucleotide binding] 890402002103 dimerization interface [polypeptide binding]; other site 890402002104 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 890402002105 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 890402002106 FtsX-like permease family; Region: FtsX; pfam02687 890402002107 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 890402002108 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 890402002109 Walker A/P-loop; other site 890402002110 ATP binding site [chemical binding]; other site 890402002111 Q-loop/lid; other site 890402002112 ABC transporter signature motif; other site 890402002113 Walker B; other site 890402002114 D-loop; other site 890402002115 H-loop/switch region; other site 890402002116 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 890402002117 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 890402002118 homodimer interface [polypeptide binding]; other site 890402002119 substrate-cofactor binding pocket; other site 890402002120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402002121 catalytic residue [active] 890402002122 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 890402002123 dimer interface [polypeptide binding]; other site 890402002124 pyridoxal binding site [chemical binding]; other site 890402002125 ATP binding site [chemical binding]; other site 890402002126 hypothetical protein; Provisional; Region: PRK14681 890402002127 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 890402002128 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 890402002129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402002130 Walker A motif; other site 890402002131 ATP binding site [chemical binding]; other site 890402002132 Walker B motif; other site 890402002133 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 890402002134 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 890402002135 DNA protecting protein DprA; Region: dprA; TIGR00732 890402002136 L-aspartate oxidase; Provisional; Region: PRK06175 890402002137 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 890402002138 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 890402002139 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 890402002140 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 890402002141 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 890402002142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 890402002143 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 890402002144 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 890402002145 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 890402002146 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 890402002147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402002148 Walker A motif; other site 890402002149 ATP binding site [chemical binding]; other site 890402002150 Walker B motif; other site 890402002151 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 890402002152 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 890402002153 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 890402002154 oligomer interface [polypeptide binding]; other site 890402002155 active site residues [active] 890402002156 Clp protease; Region: CLP_protease; pfam00574 890402002157 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 890402002158 oligomer interface [polypeptide binding]; other site 890402002159 active site residues [active] 890402002160 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 890402002161 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 890402002162 putative ion selectivity filter; other site 890402002163 putative pore gating glutamate residue; other site 890402002164 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 890402002165 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 890402002166 dimer interface [polypeptide binding]; other site 890402002167 trigger factor; Provisional; Region: tig; PRK01490 890402002168 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 890402002169 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 890402002170 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 890402002171 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 890402002172 active site 890402002173 catalytic site [active] 890402002174 substrate binding site [chemical binding]; other site 890402002175 HRDC domain; Region: HRDC; pfam00570 890402002176 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 890402002177 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 890402002178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 890402002179 FeS/SAM binding site; other site 890402002180 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 890402002181 Pyruvate formate lyase 1; Region: PFL1; cd01678 890402002182 coenzyme A binding site [chemical binding]; other site 890402002183 active site 890402002184 catalytic residues [active] 890402002185 glycine loop; other site 890402002186 NAD synthetase; Provisional; Region: PRK13981 890402002187 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 890402002188 multimer interface [polypeptide binding]; other site 890402002189 active site 890402002190 catalytic triad [active] 890402002191 protein interface 1 [polypeptide binding]; other site 890402002192 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 890402002193 homodimer interface [polypeptide binding]; other site 890402002194 NAD binding pocket [chemical binding]; other site 890402002195 ATP binding pocket [chemical binding]; other site 890402002196 Mg binding site [ion binding]; other site 890402002197 active-site loop [active] 890402002198 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 890402002199 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 890402002200 metal binding site [ion binding]; metal-binding site 890402002201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 890402002202 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 890402002203 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 890402002204 Walker A/P-loop; other site 890402002205 ATP binding site [chemical binding]; other site 890402002206 Q-loop/lid; other site 890402002207 ABC transporter signature motif; other site 890402002208 Walker B; other site 890402002209 D-loop; other site 890402002210 H-loop/switch region; other site 890402002211 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 890402002212 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 890402002213 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 890402002214 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 890402002215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 890402002216 active site 890402002217 motif I; other site 890402002218 motif II; other site 890402002219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 890402002220 putative phosphoketolase; Provisional; Region: PRK05261 890402002221 XFP N-terminal domain; Region: XFP_N; pfam09364 890402002222 XFP C-terminal domain; Region: XFP_C; pfam09363 890402002223 GMP synthase; Reviewed; Region: guaA; PRK00074 890402002224 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 890402002225 AMP/PPi binding site [chemical binding]; other site 890402002226 candidate oxyanion hole; other site 890402002227 catalytic triad [active] 890402002228 potential glutamine specificity residues [chemical binding]; other site 890402002229 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 890402002230 ATP Binding subdomain [chemical binding]; other site 890402002231 Ligand Binding sites [chemical binding]; other site 890402002232 Dimerization subdomain; other site 890402002233 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 890402002234 Sodium Bile acid symporter family; Region: SBF; cl17470 890402002235 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 890402002236 Low molecular weight phosphatase family; Region: LMWPc; cd00115 890402002237 active site 890402002238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 890402002239 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 890402002240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 890402002241 transposase/IS protein; Provisional; Region: PRK09183 890402002242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402002243 Walker A motif; other site 890402002244 ATP binding site [chemical binding]; other site 890402002245 Walker B motif; other site 890402002246 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 890402002247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 890402002248 DNA-binding interface [nucleotide binding]; DNA binding site 890402002249 Integrase core domain; Region: rve; pfam00665 890402002250 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 890402002251 Integrase core domain; Region: rve; pfam00665 890402002252 transposase; Provisional; Region: PRK06526 890402002253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402002254 Walker A motif; other site 890402002255 ATP binding site [chemical binding]; other site 890402002256 Walker B motif; other site 890402002257 Major Facilitator Superfamily; Region: MFS_1; pfam07690 890402002258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402002259 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 890402002260 Protein of unknown function, DUF600; Region: DUF600; cl04640 890402002261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 890402002262 hypothetical protein; Provisional; Region: PRK13663 890402002263 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 890402002264 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 890402002265 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 890402002266 active site 890402002267 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 890402002268 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 890402002269 Substrate binding site; other site 890402002270 Mg++ binding site; other site 890402002271 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 890402002272 active site 890402002273 substrate binding site [chemical binding]; other site 890402002274 CoA binding site [chemical binding]; other site 890402002275 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 890402002276 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 890402002277 catalytic core [active] 890402002278 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 890402002279 propionate/acetate kinase; Provisional; Region: PRK12379 890402002280 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 890402002281 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 890402002282 hinge; other site 890402002283 active site 890402002284 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 890402002285 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 890402002286 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 890402002287 active site 890402002288 catalytic site [active] 890402002289 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 890402002290 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 890402002291 dimer interface [polypeptide binding]; other site 890402002292 ADP-ribose binding site [chemical binding]; other site 890402002293 active site 890402002294 nudix motif; other site 890402002295 metal binding site [ion binding]; metal-binding site 890402002296 Uncharacterized conserved protein [Function unknown]; Region: COG0327 890402002297 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 890402002298 DNA polymerase I; Provisional; Region: PRK05755 890402002299 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 890402002300 active site 890402002301 metal binding site 1 [ion binding]; metal-binding site 890402002302 putative 5' ssDNA interaction site; other site 890402002303 metal binding site 3; metal-binding site 890402002304 metal binding site 2 [ion binding]; metal-binding site 890402002305 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 890402002306 putative DNA binding site [nucleotide binding]; other site 890402002307 putative metal binding site [ion binding]; other site 890402002308 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 890402002309 active site 890402002310 substrate binding site [chemical binding]; other site 890402002311 catalytic site [active] 890402002312 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 890402002313 active site 890402002314 DNA binding site [nucleotide binding] 890402002315 catalytic site [active] 890402002316 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 890402002317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 890402002318 active site 890402002319 phosphorylation site [posttranslational modification] 890402002320 intermolecular recognition site; other site 890402002321 dimerization interface [polypeptide binding]; other site 890402002322 ANTAR domain; Region: ANTAR; pfam03861 890402002323 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 890402002324 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 890402002325 dimer interface [polypeptide binding]; other site 890402002326 ADP-ribose binding site [chemical binding]; other site 890402002327 active site 890402002328 nudix motif; other site 890402002329 metal binding site [ion binding]; metal-binding site 890402002330 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 890402002331 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 890402002332 domain interfaces; other site 890402002333 active site 890402002334 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 890402002335 excinuclease ABC subunit B; Provisional; Region: PRK05298 890402002336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 890402002337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 890402002338 nucleotide binding region [chemical binding]; other site 890402002339 ATP-binding site [chemical binding]; other site 890402002340 Ultra-violet resistance protein B; Region: UvrB; pfam12344 890402002341 UvrB/uvrC motif; Region: UVR; pfam02151 890402002342 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 890402002343 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 890402002344 CoA-binding site [chemical binding]; other site 890402002345 ATP-binding [chemical binding]; other site 890402002346 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 890402002347 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 890402002348 RNA binding site [nucleotide binding]; other site 890402002349 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 890402002350 RNA binding site [nucleotide binding]; other site 890402002351 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 890402002352 RNA binding site [nucleotide binding]; other site 890402002353 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 890402002354 RNA binding site [nucleotide binding]; other site 890402002355 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 890402002356 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 890402002357 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 890402002358 homodimer interface [polypeptide binding]; other site 890402002359 NADP binding site [chemical binding]; other site 890402002360 substrate binding site [chemical binding]; other site 890402002361 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 890402002362 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 890402002363 metal binding site [ion binding]; metal-binding site 890402002364 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 890402002365 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 890402002366 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 890402002367 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 890402002368 ABC-ATPase subunit interface; other site 890402002369 dimer interface [polypeptide binding]; other site 890402002370 putative PBP binding regions; other site 890402002371 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 890402002372 homotrimer interaction site [polypeptide binding]; other site 890402002373 CDP-binding sites; other site 890402002374 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 890402002375 glycogen branching enzyme; Provisional; Region: PRK05402 890402002376 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 890402002377 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 890402002378 active site 890402002379 catalytic site [active] 890402002380 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 890402002381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 890402002382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 890402002383 active site 890402002384 phosphorylation site [posttranslational modification] 890402002385 intermolecular recognition site; other site 890402002386 dimerization interface [polypeptide binding]; other site 890402002387 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 890402002388 DNA binding site [nucleotide binding] 890402002389 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 890402002390 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 890402002391 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 890402002392 dimerization interface [polypeptide binding]; other site 890402002393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 890402002394 dimer interface [polypeptide binding]; other site 890402002395 phosphorylation site [posttranslational modification] 890402002396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 890402002397 ATP binding site [chemical binding]; other site 890402002398 Mg2+ binding site [ion binding]; other site 890402002399 G-X-G motif; other site 890402002400 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 890402002401 Catalytic site [active] 890402002402 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 890402002403 Eukaryotic phosphomannomutase; Region: PMM; cl17107 890402002404 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 890402002405 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 890402002406 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 890402002407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 890402002408 Transcription factor WhiB; Region: Whib; pfam02467 890402002409 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 890402002410 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 890402002411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402002412 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 890402002413 Walker A/P-loop; other site 890402002414 ATP binding site [chemical binding]; other site 890402002415 Transcription factor WhiB; Region: Whib; pfam02467 890402002416 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 890402002417 PAS fold; Region: PAS_4; pfam08448 890402002418 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 890402002419 Histidine kinase; Region: HisKA_2; pfam07568 890402002420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 890402002421 ATP binding site [chemical binding]; other site 890402002422 Mg2+ binding site [ion binding]; other site 890402002423 G-X-G motif; other site 890402002424 Haemolysin-III related; Region: HlyIII; pfam03006 890402002425 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 890402002426 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 890402002427 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 890402002428 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 890402002429 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 890402002430 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 890402002431 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 890402002432 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 890402002433 exopolyphosphatase; Region: exo_poly_only; TIGR03706 890402002434 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 890402002435 Protein of unknown function (DUF501); Region: DUF501; pfam04417 890402002436 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 890402002437 Septum formation initiator; Region: DivIC; pfam04977 890402002438 enolase; Provisional; Region: eno; PRK00077 890402002439 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 890402002440 dimer interface [polypeptide binding]; other site 890402002441 metal binding site [ion binding]; metal-binding site 890402002442 substrate binding pocket [chemical binding]; other site 890402002443 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 890402002444 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 890402002445 active site 890402002446 catalytic tetrad [active] 890402002447 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 890402002448 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 890402002449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 890402002450 ATP binding site [chemical binding]; other site 890402002451 putative Mg++ binding site [ion binding]; other site 890402002452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 890402002453 nucleotide binding region [chemical binding]; other site 890402002454 ATP-binding site [chemical binding]; other site 890402002455 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 890402002456 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 890402002457 putative active site [active] 890402002458 catalytic residue [active] 890402002459 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 890402002460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 890402002461 Coenzyme A binding pocket [chemical binding]; other site 890402002462 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 890402002463 Uncharacterized conserved protein [Function unknown]; Region: COG1615 890402002464 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 890402002465 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 890402002466 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 890402002467 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 890402002468 active site 890402002469 (T/H)XGH motif; other site 890402002470 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 890402002471 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 890402002472 putative catalytic cysteine [active] 890402002473 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 890402002474 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 890402002475 dimer interface [polypeptide binding]; other site 890402002476 active site 890402002477 glycine-pyridoxal phosphate binding site [chemical binding]; other site 890402002478 folate binding site [chemical binding]; other site 890402002479 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 890402002480 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 890402002481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402002482 catalytic residue [active] 890402002483 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 890402002484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 890402002485 Integrase core domain; Region: rve; pfam00665 890402002486 transposase; Provisional; Region: PRK06526 890402002487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402002488 Walker A motif; other site 890402002489 ATP binding site [chemical binding]; other site 890402002490 Walker B motif; other site 890402002491 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 890402002492 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 890402002493 G1 box; other site 890402002494 putative GEF interaction site [polypeptide binding]; other site 890402002495 GTP/Mg2+ binding site [chemical binding]; other site 890402002496 Switch I region; other site 890402002497 G2 box; other site 890402002498 G3 box; other site 890402002499 Switch II region; other site 890402002500 G4 box; other site 890402002501 G5 box; other site 890402002502 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 890402002503 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 890402002504 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 890402002505 Winged helix-turn helix; Region: HTH_29; pfam13551 890402002506 Helix-turn-helix domain; Region: HTH_28; pfam13518 890402002507 HTH-like domain; Region: HTH_21; pfam13276 890402002508 Integrase core domain; Region: rve; pfam00665 890402002509 Integrase core domain; Region: rve_2; pfam13333 890402002510 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 890402002511 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 890402002512 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 890402002513 Walker A/P-loop; other site 890402002514 ATP binding site [chemical binding]; other site 890402002515 Q-loop/lid; other site 890402002516 ABC transporter signature motif; other site 890402002517 Walker B; other site 890402002518 D-loop; other site 890402002519 H-loop/switch region; other site 890402002520 Predicted transcriptional regulators [Transcription]; Region: COG1725 890402002521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 890402002522 DNA-binding site [nucleotide binding]; DNA binding site 890402002523 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 890402002524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 890402002525 motif II; other site 890402002526 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 890402002527 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 890402002528 Walker A/P-loop; other site 890402002529 ATP binding site [chemical binding]; other site 890402002530 Q-loop/lid; other site 890402002531 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 890402002532 ABC transporter signature motif; other site 890402002533 Walker B; other site 890402002534 D-loop; other site 890402002535 H-loop/switch region; other site 890402002536 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 890402002537 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 890402002538 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 890402002539 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 890402002540 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 890402002541 TrkA-N domain; Region: TrkA_N; pfam02254 890402002542 TrkA-C domain; Region: TrkA_C; pfam02080 890402002543 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 890402002544 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 890402002545 RNA binding surface [nucleotide binding]; other site 890402002546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 890402002547 S-adenosylmethionine binding site [chemical binding]; other site 890402002548 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 890402002549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 890402002550 active site 890402002551 motif I; other site 890402002552 motif II; other site 890402002553 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 890402002554 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 890402002555 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 890402002556 active site 890402002557 HIGH motif; other site 890402002558 dimer interface [polypeptide binding]; other site 890402002559 KMSKS motif; other site 890402002560 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 890402002561 RNA binding surface [nucleotide binding]; other site 890402002562 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 890402002563 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 890402002564 Zn2+ binding site [ion binding]; other site 890402002565 Mg2+ binding site [ion binding]; other site 890402002566 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 890402002567 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 890402002568 ATP binding site [chemical binding]; other site 890402002569 substrate interface [chemical binding]; other site 890402002570 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 890402002571 ThiS interaction site; other site 890402002572 putative active site [active] 890402002573 tetramer interface [polypeptide binding]; other site 890402002574 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 890402002575 thiS-thiF/thiG interaction site; other site 890402002576 argininosuccinate lyase; Provisional; Region: PRK00855 890402002577 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 890402002578 active sites [active] 890402002579 tetramer interface [polypeptide binding]; other site 890402002580 argininosuccinate synthase; Provisional; Region: PRK13820 890402002581 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 890402002582 ANP binding site [chemical binding]; other site 890402002583 Substrate Binding Site II [chemical binding]; other site 890402002584 Substrate Binding Site I [chemical binding]; other site 890402002585 arginine repressor; Provisional; Region: PRK03341 890402002586 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 890402002587 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 890402002588 ornithine carbamoyltransferase; Provisional; Region: PRK00779 890402002589 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 890402002590 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 890402002591 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 890402002592 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 890402002593 inhibitor-cofactor binding pocket; inhibition site 890402002594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402002595 catalytic residue [active] 890402002596 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 890402002597 feedback inhibition sensing region; other site 890402002598 homohexameric interface [polypeptide binding]; other site 890402002599 nucleotide binding site [chemical binding]; other site 890402002600 N-acetyl-L-glutamate binding site [chemical binding]; other site 890402002601 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 890402002602 heterotetramer interface [polypeptide binding]; other site 890402002603 active site pocket [active] 890402002604 cleavage site 890402002605 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 890402002606 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 890402002607 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 890402002608 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 890402002609 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 890402002610 putative tRNA-binding site [nucleotide binding]; other site 890402002611 B3/4 domain; Region: B3_4; pfam03483 890402002612 tRNA synthetase B5 domain; Region: B5; pfam03484 890402002613 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 890402002614 dimer interface [polypeptide binding]; other site 890402002615 motif 1; other site 890402002616 motif 3; other site 890402002617 motif 2; other site 890402002618 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 890402002619 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 890402002620 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 890402002621 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 890402002622 dimer interface [polypeptide binding]; other site 890402002623 motif 1; other site 890402002624 active site 890402002625 motif 2; other site 890402002626 motif 3; other site 890402002627 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 890402002628 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 890402002629 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 890402002630 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 890402002631 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 890402002632 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 890402002633 Walker A/P-loop; other site 890402002634 ATP binding site [chemical binding]; other site 890402002635 Q-loop/lid; other site 890402002636 ABC transporter signature motif; other site 890402002637 Walker B; other site 890402002638 D-loop; other site 890402002639 H-loop/switch region; other site 890402002640 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 890402002641 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 890402002642 Walker A/P-loop; other site 890402002643 ATP binding site [chemical binding]; other site 890402002644 Q-loop/lid; other site 890402002645 ABC transporter signature motif; other site 890402002646 Walker B; other site 890402002647 D-loop; other site 890402002648 H-loop/switch region; other site 890402002649 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 890402002650 hypothetical protein; Provisional; Region: PRK07907 890402002651 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 890402002652 active site 890402002653 metal binding site [ion binding]; metal-binding site 890402002654 dimer interface [polypeptide binding]; other site 890402002655 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 890402002656 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 890402002657 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 890402002658 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 890402002659 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 890402002660 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 890402002661 glutamine synthetase, type I; Region: GlnA; TIGR00653 890402002662 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 890402002663 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 890402002664 Predicted permeases [General function prediction only]; Region: COG0679 890402002665 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 890402002666 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 890402002667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402002668 Walker A/P-loop; other site 890402002669 ATP binding site [chemical binding]; other site 890402002670 Q-loop/lid; other site 890402002671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402002672 ABC transporter signature motif; other site 890402002673 Walker B; other site 890402002674 D-loop; other site 890402002675 H-loop/switch region; other site 890402002676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402002677 Walker A/P-loop; other site 890402002678 ATP binding site [chemical binding]; other site 890402002679 Q-loop/lid; other site 890402002680 ABC transporter signature motif; other site 890402002681 Walker B; other site 890402002682 D-loop; other site 890402002683 H-loop/switch region; other site 890402002684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 890402002685 dimerization interface [polypeptide binding]; other site 890402002686 putative DNA binding site [nucleotide binding]; other site 890402002687 putative Zn2+ binding site [ion binding]; other site 890402002688 AAA domain; Region: AAA_14; pfam13173 890402002689 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 890402002690 Predicted transcriptional regulators [Transcription]; Region: COG1725 890402002691 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 890402002692 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 890402002693 catalytic Zn binding site [ion binding]; other site 890402002694 NAD(P) binding site [chemical binding]; other site 890402002695 structural Zn binding site [ion binding]; other site 890402002696 CrcB-like protein; Region: CRCB; pfam02537 890402002697 CrcB-like protein; Region: CRCB; pfam02537 890402002698 Predicted membrane protein [Function unknown]; Region: COG2246 890402002699 GtrA-like protein; Region: GtrA; pfam04138 890402002700 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 890402002701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 890402002702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 890402002703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 890402002704 dimerization interface [polypeptide binding]; other site 890402002705 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 890402002706 elongation factor Tu; Reviewed; Region: PRK00049 890402002707 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 890402002708 G1 box; other site 890402002709 GEF interaction site [polypeptide binding]; other site 890402002710 GTP/Mg2+ binding site [chemical binding]; other site 890402002711 Switch I region; other site 890402002712 G2 box; other site 890402002713 G3 box; other site 890402002714 Switch II region; other site 890402002715 G4 box; other site 890402002716 G5 box; other site 890402002717 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 890402002718 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 890402002719 Antibiotic Binding Site [chemical binding]; other site 890402002720 elongation factor G; Reviewed; Region: PRK00007 890402002721 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 890402002722 G1 box; other site 890402002723 putative GEF interaction site [polypeptide binding]; other site 890402002724 GTP/Mg2+ binding site [chemical binding]; other site 890402002725 Switch I region; other site 890402002726 G2 box; other site 890402002727 G3 box; other site 890402002728 Switch II region; other site 890402002729 G4 box; other site 890402002730 G5 box; other site 890402002731 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 890402002732 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 890402002733 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 890402002734 30S ribosomal protein S7; Validated; Region: PRK05302 890402002735 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 890402002736 S17 interaction site [polypeptide binding]; other site 890402002737 S8 interaction site; other site 890402002738 16S rRNA interaction site [nucleotide binding]; other site 890402002739 streptomycin interaction site [chemical binding]; other site 890402002740 23S rRNA interaction site [nucleotide binding]; other site 890402002741 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 890402002742 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 890402002743 Sodium Bile acid symporter family; Region: SBF; pfam01758 890402002744 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 890402002745 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 890402002746 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 890402002747 catalytic residue [active] 890402002748 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 890402002749 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 890402002750 putative ADP-binding pocket [chemical binding]; other site 890402002751 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 890402002752 ATP-grasp domain; Region: ATP-grasp; pfam02222 890402002753 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 890402002754 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 890402002755 ATP binding site [chemical binding]; other site 890402002756 active site 890402002757 substrate binding site [chemical binding]; other site 890402002758 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 890402002759 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 890402002760 dimerization interface [polypeptide binding]; other site 890402002761 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 890402002762 dimerization interface [polypeptide binding]; other site 890402002763 ATP binding site [chemical binding]; other site 890402002764 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 890402002765 dimerization interface [polypeptide binding]; other site 890402002766 ATP binding site [chemical binding]; other site 890402002767 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 890402002768 putative active site [active] 890402002769 catalytic triad [active] 890402002770 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 890402002771 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 890402002772 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 890402002773 Transcriptional regulator [Transcription]; Region: LysR; COG0583 890402002774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 890402002775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 890402002776 dimerization interface [polypeptide binding]; other site 890402002777 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 890402002778 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 890402002779 active site 890402002780 catalytic tetrad [active] 890402002781 DNA polymerase IV; Reviewed; Region: PRK03103 890402002782 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 890402002783 active site 890402002784 DNA binding site [nucleotide binding] 890402002785 guanine deaminase; Region: guan_deamin; TIGR02967 890402002786 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 890402002787 active site 890402002788 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 890402002789 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 890402002790 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 890402002791 substrate binding pocket [chemical binding]; other site 890402002792 membrane-bound complex binding site; other site 890402002793 hinge residues; other site 890402002794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402002795 dimer interface [polypeptide binding]; other site 890402002796 conserved gate region; other site 890402002797 putative PBP binding loops; other site 890402002798 ABC-ATPase subunit interface; other site 890402002799 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 890402002800 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 890402002801 Walker A/P-loop; other site 890402002802 ATP binding site [chemical binding]; other site 890402002803 Q-loop/lid; other site 890402002804 ABC transporter signature motif; other site 890402002805 Walker B; other site 890402002806 D-loop; other site 890402002807 H-loop/switch region; other site 890402002808 amidophosphoribosyltransferase; Provisional; Region: PRK07272 890402002809 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 890402002810 active site 890402002811 tetramer interface [polypeptide binding]; other site 890402002812 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 890402002813 active site 890402002814 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 890402002815 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 890402002816 dimerization interface [polypeptide binding]; other site 890402002817 putative ATP binding site [chemical binding]; other site 890402002818 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 890402002819 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 890402002820 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 890402002821 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 890402002822 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 890402002823 NAD(P) binding site [chemical binding]; other site 890402002824 catalytic residues [active] 890402002825 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 890402002826 Sulfatase; Region: Sulfatase; pfam00884 890402002827 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 890402002828 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 890402002829 metal binding site [ion binding]; metal-binding site 890402002830 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 890402002831 metal binding site 2 [ion binding]; metal-binding site 890402002832 putative DNA binding helix; other site 890402002833 metal binding site 1 [ion binding]; metal-binding site 890402002834 dimer interface [polypeptide binding]; other site 890402002835 structural Zn2+ binding site [ion binding]; other site 890402002836 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 890402002837 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 890402002838 NAD binding site [chemical binding]; other site 890402002839 ATP-grasp domain; Region: ATP-grasp; pfam02222 890402002840 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 890402002841 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 890402002842 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 890402002843 NAD(P) binding site [chemical binding]; other site 890402002844 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 890402002845 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 890402002846 TPP-binding site; other site 890402002847 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 890402002848 PYR/PP interface [polypeptide binding]; other site 890402002849 dimer interface [polypeptide binding]; other site 890402002850 TPP binding site [chemical binding]; other site 890402002851 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 890402002852 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 890402002853 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 890402002854 FtsX-like permease family; Region: FtsX; pfam02687 890402002855 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 890402002856 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 890402002857 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 890402002858 Walker A/P-loop; other site 890402002859 ATP binding site [chemical binding]; other site 890402002860 Q-loop/lid; other site 890402002861 ABC transporter signature motif; other site 890402002862 Walker B; other site 890402002863 D-loop; other site 890402002864 H-loop/switch region; other site 890402002865 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 890402002866 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 890402002867 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 890402002868 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 890402002869 putative active site [active] 890402002870 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 890402002871 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 890402002872 transmembrane helices; other site 890402002873 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 890402002874 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 890402002875 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 890402002876 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 890402002877 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 890402002878 ATP-grasp domain; Region: ATP-grasp_4; cl17255 890402002879 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 890402002880 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 890402002881 carboxyltransferase (CT) interaction site; other site 890402002882 biotinylation site [posttranslational modification]; other site 890402002883 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 890402002884 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 890402002885 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 890402002886 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 890402002887 putative active site [active] 890402002888 hypothetical protein; Provisional; Region: PRK05463 890402002889 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07849 890402002890 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 890402002891 homodimer interface [polypeptide binding]; other site 890402002892 substrate-cofactor binding pocket; other site 890402002893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402002894 catalytic residue [active] 890402002895 putative transposase OrfB; Reviewed; Region: PHA02517 890402002896 HTH-like domain; Region: HTH_21; pfam13276 890402002897 Integrase core domain; Region: rve_3; pfam13683 890402002898 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 890402002899 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 890402002900 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 890402002901 active site 890402002902 dimer interface [polypeptide binding]; other site 890402002903 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 890402002904 homodimer interface [polypeptide binding]; other site 890402002905 homotetramer interface [polypeptide binding]; other site 890402002906 active site pocket [active] 890402002907 cleavage site 890402002908 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 890402002909 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 890402002910 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 890402002911 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 890402002912 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 890402002913 catalytic nucleophile [active] 890402002914 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 890402002915 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 890402002916 DNA-binding site [nucleotide binding]; DNA binding site 890402002917 Rhoptry-associated protein 1 (RAP-1); Region: RAP1; pfam07218 890402002918 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 890402002919 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 890402002920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402002921 homodimer interface [polypeptide binding]; other site 890402002922 catalytic residue [active] 890402002923 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 890402002924 predicted active site [active] 890402002925 catalytic triad [active] 890402002926 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 890402002927 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 890402002928 active site 890402002929 multimer interface [polypeptide binding]; other site 890402002930 DNA primase, catalytic core; Region: dnaG; TIGR01391 890402002931 CHC2 zinc finger; Region: zf-CHC2; cl17510 890402002932 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 890402002933 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 890402002934 active site 890402002935 metal binding site [ion binding]; metal-binding site 890402002936 interdomain interaction site; other site 890402002937 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 890402002938 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 890402002939 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 890402002940 Zn2+ binding site [ion binding]; other site 890402002941 Mg2+ binding site [ion binding]; other site 890402002942 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 890402002943 alanine racemase; Reviewed; Region: alr; PRK00053 890402002944 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 890402002945 active site 890402002946 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 890402002947 dimer interface [polypeptide binding]; other site 890402002948 substrate binding site [chemical binding]; other site 890402002949 catalytic residues [active] 890402002950 amino acid transporter; Region: 2A0306; TIGR00909 890402002951 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 890402002952 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 890402002953 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 890402002954 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 890402002955 S-ribosylhomocysteinase; Provisional; Region: PRK02260 890402002956 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 890402002957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 890402002958 ATP binding site [chemical binding]; other site 890402002959 putative Mg++ binding site [ion binding]; other site 890402002960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 890402002961 nucleotide binding region [chemical binding]; other site 890402002962 ATP-binding site [chemical binding]; other site 890402002963 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 890402002964 HRDC domain; Region: HRDC; pfam00570 890402002965 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 890402002966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 890402002967 cystathionine gamma-synthase; Provisional; Region: PRK07811 890402002968 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 890402002969 homodimer interface [polypeptide binding]; other site 890402002970 substrate-cofactor binding pocket; other site 890402002971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402002972 catalytic residue [active] 890402002973 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 890402002974 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 890402002975 dimer interface [polypeptide binding]; other site 890402002976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402002977 catalytic residue [active] 890402002978 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 890402002979 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 890402002980 Walker A/P-loop; other site 890402002981 ATP binding site [chemical binding]; other site 890402002982 Q-loop/lid; other site 890402002983 ABC transporter signature motif; other site 890402002984 Walker B; other site 890402002985 D-loop; other site 890402002986 H-loop/switch region; other site 890402002987 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 890402002988 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 890402002989 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 890402002990 Walker A/P-loop; other site 890402002991 ATP binding site [chemical binding]; other site 890402002992 Q-loop/lid; other site 890402002993 ABC transporter signature motif; other site 890402002994 Walker B; other site 890402002995 D-loop; other site 890402002996 H-loop/switch region; other site 890402002997 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 890402002998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402002999 ABC-ATPase subunit interface; other site 890402003000 putative PBP binding loops; other site 890402003001 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 890402003002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402003003 putative PBP binding loops; other site 890402003004 dimer interface [polypeptide binding]; other site 890402003005 ABC-ATPase subunit interface; other site 890402003006 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 890402003007 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 890402003008 pantothenate kinase; Reviewed; Region: PRK13318 890402003009 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 890402003010 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 890402003011 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 890402003012 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 890402003013 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 890402003014 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 890402003015 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 890402003016 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 890402003017 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402003018 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402003019 DNA binding site [nucleotide binding] 890402003020 domain linker motif; other site 890402003021 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402003022 ligand binding site [chemical binding]; other site 890402003023 dimerization interface [polypeptide binding]; other site 890402003024 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 890402003025 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 890402003026 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 890402003027 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 890402003028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402003029 dimer interface [polypeptide binding]; other site 890402003030 conserved gate region; other site 890402003031 putative PBP binding loops; other site 890402003032 ABC-ATPase subunit interface; other site 890402003033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402003034 dimer interface [polypeptide binding]; other site 890402003035 conserved gate region; other site 890402003036 putative PBP binding loops; other site 890402003037 ABC-ATPase subunit interface; other site 890402003038 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402003039 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402003040 DNA binding site [nucleotide binding] 890402003041 domain linker motif; other site 890402003042 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 890402003043 ligand binding site [chemical binding]; other site 890402003044 dimerization interface (open form) [polypeptide binding]; other site 890402003045 dimerization interface (closed form) [polypeptide binding]; other site 890402003046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 890402003047 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 890402003048 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 890402003049 active site 890402003050 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 890402003051 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 890402003052 glutaminase active site [active] 890402003053 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 890402003054 dimer interface [polypeptide binding]; other site 890402003055 active site 890402003056 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 890402003057 dimer interface [polypeptide binding]; other site 890402003058 active site 890402003059 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 890402003060 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 890402003061 Walker A/P-loop; other site 890402003062 ATP binding site [chemical binding]; other site 890402003063 Q-loop/lid; other site 890402003064 ABC transporter signature motif; other site 890402003065 Walker B; other site 890402003066 D-loop; other site 890402003067 H-loop/switch region; other site 890402003068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402003069 dimer interface [polypeptide binding]; other site 890402003070 conserved gate region; other site 890402003071 putative PBP binding loops; other site 890402003072 ABC-ATPase subunit interface; other site 890402003073 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 890402003074 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 890402003075 substrate binding pocket [chemical binding]; other site 890402003076 membrane-bound complex binding site; other site 890402003077 hinge residues; other site 890402003078 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 890402003079 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 890402003080 substrate binding pocket [chemical binding]; other site 890402003081 membrane-bound complex binding site; other site 890402003082 hinge residues; other site 890402003083 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 890402003084 SmpB-tmRNA interface; other site 890402003085 CHAP domain; Region: CHAP; pfam05257 890402003086 Surface antigen [General function prediction only]; Region: COG3942 890402003087 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 890402003088 FtsX-like permease family; Region: FtsX; pfam02687 890402003089 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 890402003090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402003091 Walker A/P-loop; other site 890402003092 ATP binding site [chemical binding]; other site 890402003093 Q-loop/lid; other site 890402003094 ABC transporter signature motif; other site 890402003095 Walker B; other site 890402003096 D-loop; other site 890402003097 H-loop/switch region; other site 890402003098 peptide chain release factor 2; Validated; Region: prfB; PRK00578 890402003099 This domain is found in peptide chain release factors; Region: PCRF; smart00937 890402003100 RF-1 domain; Region: RF-1; pfam00472 890402003101 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 890402003102 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 890402003103 active site 890402003104 substrate binding site [chemical binding]; other site 890402003105 catalytic site [active] 890402003106 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 890402003107 active site 890402003108 catalytic residues [active] 890402003109 metal binding site [ion binding]; metal-binding site 890402003110 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 890402003111 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 890402003112 active site 890402003113 substrate binding site [chemical binding]; other site 890402003114 metal binding site [ion binding]; metal-binding site 890402003115 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 890402003116 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 890402003117 Zn binding site [ion binding]; other site 890402003118 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 890402003119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 890402003120 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 890402003121 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 890402003122 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 890402003123 dimer interface [polypeptide binding]; other site 890402003124 active site 890402003125 catalytic residue [active] 890402003126 dihydrodipicolinate reductase; Provisional; Region: PRK00048 890402003127 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 890402003128 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 890402003129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 890402003130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402003131 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 890402003132 Family description; Region: UvrD_C_2; pfam13538 890402003133 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 890402003134 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 890402003135 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 890402003136 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 890402003137 Catalytic domain of Protein Kinases; Region: PKc; cd00180 890402003138 active site 890402003139 ATP binding site [chemical binding]; other site 890402003140 substrate binding site [chemical binding]; other site 890402003141 activation loop (A-loop); other site 890402003142 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 890402003143 Interdomain contacts; other site 890402003144 Cytokine receptor motif; other site 890402003145 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 890402003146 Interdomain contacts; other site 890402003147 Cytokine receptor motif; other site 890402003148 MoxR-like ATPases [General function prediction only]; Region: COG0714 890402003149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402003150 Walker A motif; other site 890402003151 ATP binding site [chemical binding]; other site 890402003152 Walker B motif; other site 890402003153 arginine finger; other site 890402003154 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 890402003155 Protein of unknown function DUF58; Region: DUF58; pfam01882 890402003156 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 890402003157 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 890402003158 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 890402003159 active site 890402003160 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 890402003161 phosphopeptide binding site; other site 890402003162 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 890402003163 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 890402003164 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 890402003165 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 890402003166 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 890402003167 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 890402003168 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 890402003169 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 890402003170 DNA binding site [nucleotide binding] 890402003171 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 890402003172 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 890402003173 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 890402003174 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 890402003175 RPB1 interaction site [polypeptide binding]; other site 890402003176 RPB10 interaction site [polypeptide binding]; other site 890402003177 RPB11 interaction site [polypeptide binding]; other site 890402003178 RPB3 interaction site [polypeptide binding]; other site 890402003179 RPB12 interaction site [polypeptide binding]; other site 890402003180 Alphaherpesvirus tegument protein US9; Region: Herpes_US9; pfam06072 890402003181 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 890402003182 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 890402003183 minor groove reading motif; other site 890402003184 helix-hairpin-helix signature motif; other site 890402003185 active site 890402003186 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 890402003187 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 890402003188 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 890402003189 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 890402003190 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 890402003191 galactokinase; Provisional; Region: PRK05322 890402003192 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 890402003193 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 890402003194 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 890402003195 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 890402003196 dimer interface [polypeptide binding]; other site 890402003197 active site 890402003198 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 890402003199 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 890402003200 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 890402003201 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 890402003202 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 890402003203 quinone interaction residues [chemical binding]; other site 890402003204 active site 890402003205 catalytic residues [active] 890402003206 FMN binding site [chemical binding]; other site 890402003207 substrate binding site [chemical binding]; other site 890402003208 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 890402003209 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 890402003210 active site 890402003211 FMN binding site [chemical binding]; other site 890402003212 substrate binding site [chemical binding]; other site 890402003213 homotetramer interface [polypeptide binding]; other site 890402003214 catalytic residue [active] 890402003215 Transglycosylase; Region: Transgly; pfam00912 890402003216 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 890402003217 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 890402003218 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 890402003219 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 890402003220 ligand binding site [chemical binding]; other site 890402003221 flexible hinge region; other site 890402003222 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 890402003223 putative switch regulator; other site 890402003224 non-specific DNA interactions [nucleotide binding]; other site 890402003225 DNA binding site [nucleotide binding] 890402003226 sequence specific DNA binding site [nucleotide binding]; other site 890402003227 putative cAMP binding site [chemical binding]; other site 890402003228 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 890402003229 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 890402003230 tartrate dehydrogenase; Region: TTC; TIGR02089 890402003231 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 890402003232 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 890402003233 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 890402003234 Uncharacterized conserved protein [Function unknown]; Region: COG4850 890402003235 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 890402003236 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 890402003237 lipoyl attachment site [posttranslational modification]; other site 890402003238 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 890402003239 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 890402003240 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 890402003241 putative NADH binding site [chemical binding]; other site 890402003242 putative active site [active] 890402003243 nudix motif; other site 890402003244 putative metal binding site [ion binding]; other site 890402003245 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 890402003246 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 890402003247 nudix motif; other site 890402003248 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 890402003249 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 890402003250 catalytic residues [active] 890402003251 Domain of unknown function (DUF348); Region: DUF348; pfam03990 890402003252 G5 domain; Region: G5; pfam07501 890402003253 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 890402003254 N-acetyl-D-glucosamine binding site [chemical binding]; other site 890402003255 catalytic residue [active] 890402003256 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 890402003257 sequence-specific DNA binding site [nucleotide binding]; other site 890402003258 salt bridge; other site 890402003259 Low molecular weight phosphatase family; Region: LMWPc; cd00115 890402003260 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 890402003261 active site 890402003262 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 890402003263 DNA protecting protein DprA; Region: dprA; TIGR00732 890402003264 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 890402003265 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 890402003266 Domain of unknown function (DUF1919); Region: DUF1919; cl01628 890402003267 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 890402003268 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 890402003269 putative ADP-binding pocket [chemical binding]; other site 890402003270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 890402003271 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 890402003272 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 890402003273 dimer interface [polypeptide binding]; other site 890402003274 tetramer interface [polypeptide binding]; other site 890402003275 PYR/PP interface [polypeptide binding]; other site 890402003276 TPP binding site [chemical binding]; other site 890402003277 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 890402003278 TPP-binding site [chemical binding]; other site 890402003279 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 890402003280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 890402003281 Chain length determinant protein; Region: Wzz; cl15801 890402003282 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 890402003283 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 890402003284 Nucleotide binding site [chemical binding]; other site 890402003285 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 890402003286 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 890402003287 Bacterial sugar transferase; Region: Bac_transf; pfam02397 890402003288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402003289 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 890402003290 putative substrate translocation pore; other site 890402003291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402003292 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 890402003293 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 890402003294 AAA domain; Region: AAA_14; pfam13173 890402003295 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 890402003296 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 890402003297 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 890402003298 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 890402003299 active site 890402003300 catalytic tetrad [active] 890402003301 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 890402003302 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 890402003303 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 890402003304 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402003305 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402003306 DNA binding site [nucleotide binding] 890402003307 domain linker motif; other site 890402003308 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402003309 ligand binding site [chemical binding]; other site 890402003310 dimerization interface [polypeptide binding]; other site 890402003311 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 890402003312 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 890402003313 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 890402003314 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 890402003315 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 890402003316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402003317 dimer interface [polypeptide binding]; other site 890402003318 conserved gate region; other site 890402003319 putative PBP binding loops; other site 890402003320 ABC-ATPase subunit interface; other site 890402003321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402003322 dimer interface [polypeptide binding]; other site 890402003323 conserved gate region; other site 890402003324 putative PBP binding loops; other site 890402003325 ABC-ATPase subunit interface; other site 890402003326 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 890402003327 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 890402003328 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 890402003329 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 890402003330 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 890402003331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402003332 Walker A/P-loop; other site 890402003333 ATP binding site [chemical binding]; other site 890402003334 Q-loop/lid; other site 890402003335 ABC transporter signature motif; other site 890402003336 Walker B; other site 890402003337 D-loop; other site 890402003338 H-loop/switch region; other site 890402003339 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 890402003340 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 890402003341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402003342 Walker A/P-loop; other site 890402003343 ATP binding site [chemical binding]; other site 890402003344 Q-loop/lid; other site 890402003345 ABC transporter signature motif; other site 890402003346 Walker B; other site 890402003347 D-loop; other site 890402003348 H-loop/switch region; other site 890402003349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 890402003350 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 890402003351 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 890402003352 acyl-activating enzyme (AAE) consensus motif; other site 890402003353 putative AMP binding site [chemical binding]; other site 890402003354 putative active site [active] 890402003355 putative CoA binding site [chemical binding]; other site 890402003356 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 890402003357 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 890402003358 Walker A/P-loop; other site 890402003359 ATP binding site [chemical binding]; other site 890402003360 Q-loop/lid; other site 890402003361 ABC transporter signature motif; other site 890402003362 Walker B; other site 890402003363 D-loop; other site 890402003364 H-loop/switch region; other site 890402003365 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 890402003366 FtsX-like permease family; Region: FtsX; pfam02687 890402003367 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 890402003368 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 890402003369 FtsX-like permease family; Region: FtsX; pfam02687 890402003370 Peptidase C26; Region: Peptidase_C26; pfam07722 890402003371 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 890402003372 catalytic triad [active] 890402003373 L-arabinose isomerase; Provisional; Region: PRK02929 890402003374 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 890402003375 hexamer (dimer of trimers) interface [polypeptide binding]; other site 890402003376 trimer interface [polypeptide binding]; other site 890402003377 substrate binding site [chemical binding]; other site 890402003378 Mn binding site [ion binding]; other site 890402003379 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 890402003380 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 890402003381 intersubunit interface [polypeptide binding]; other site 890402003382 active site 890402003383 Zn2+ binding site [ion binding]; other site 890402003384 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 890402003385 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 890402003386 putative N- and C-terminal domain interface [polypeptide binding]; other site 890402003387 putative active site [active] 890402003388 MgATP binding site [chemical binding]; other site 890402003389 catalytic site [active] 890402003390 metal binding site [ion binding]; metal-binding site 890402003391 putative carbohydrate binding site [chemical binding]; other site 890402003392 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402003393 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402003394 DNA binding site [nucleotide binding] 890402003395 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 890402003396 ligand binding site [chemical binding]; other site 890402003397 dimerization interface (open form) [polypeptide binding]; other site 890402003398 dimerization interface (closed form) [polypeptide binding]; other site 890402003399 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 890402003400 RNA/DNA hybrid binding site [nucleotide binding]; other site 890402003401 active site 890402003402 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 890402003403 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 890402003404 Catalytic site [active] 890402003405 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 890402003406 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 890402003407 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 890402003408 active site 890402003409 dimer interface [polypeptide binding]; other site 890402003410 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 890402003411 dimer interface [polypeptide binding]; other site 890402003412 active site 890402003413 Membrane transport protein; Region: Mem_trans; cl09117 890402003414 FemAB family; Region: FemAB; pfam02388 890402003415 FemAB family; Region: FemAB; pfam02388 890402003416 FemAB family; Region: FemAB; pfam02388 890402003417 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 890402003418 active site 890402003419 dimerization interface [polypeptide binding]; other site 890402003420 ribonuclease PH; Reviewed; Region: rph; PRK00173 890402003421 Ribonuclease PH; Region: RNase_PH_bact; cd11362 890402003422 hexamer interface [polypeptide binding]; other site 890402003423 active site 890402003424 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 890402003425 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 890402003426 active site 890402003427 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 890402003428 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 890402003429 DNA binding residues [nucleotide binding] 890402003430 putative dimer interface [polypeptide binding]; other site 890402003431 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 890402003432 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 890402003433 active site 890402003434 catalytic tetrad [active] 890402003435 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 890402003436 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 890402003437 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 890402003438 active site 890402003439 (T/H)XGH motif; other site 890402003440 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 890402003441 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 890402003442 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 890402003443 ribonuclease III; Reviewed; Region: rnc; PRK00102 890402003444 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 890402003445 dimerization interface [polypeptide binding]; other site 890402003446 active site 890402003447 metal binding site [ion binding]; metal-binding site 890402003448 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 890402003449 dsRNA binding site [nucleotide binding]; other site 890402003450 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 890402003451 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 890402003452 PYR/PP interface [polypeptide binding]; other site 890402003453 dimer interface [polypeptide binding]; other site 890402003454 TPP binding site [chemical binding]; other site 890402003455 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 890402003456 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 890402003457 TPP-binding site [chemical binding]; other site 890402003458 dimer interface [polypeptide binding]; other site 890402003459 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 890402003460 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 890402003461 putative valine binding site [chemical binding]; other site 890402003462 dimer interface [polypeptide binding]; other site 890402003463 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 890402003464 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 890402003465 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 890402003466 oligomeric interface; other site 890402003467 putative active site [active] 890402003468 homodimer interface [polypeptide binding]; other site 890402003469 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 890402003470 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 890402003471 ABC transporter; Region: ABC_tran_2; pfam12848 890402003472 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 890402003473 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 890402003474 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 890402003475 catalytic triad [active] 890402003476 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 890402003477 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 890402003478 active site 890402003479 HIGH motif; other site 890402003480 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 890402003481 KMSKS motif; other site 890402003482 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 890402003483 tRNA binding surface [nucleotide binding]; other site 890402003484 anticodon binding site; other site 890402003485 Cation efflux family; Region: Cation_efflux; pfam01545 890402003486 signal recognition particle protein; Provisional; Region: PRK10867 890402003487 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 890402003488 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 890402003489 P loop; other site 890402003490 GTP binding site [chemical binding]; other site 890402003491 Signal peptide binding domain; Region: SRP_SPB; pfam02978 890402003492 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 890402003493 putative catalytic site [active] 890402003494 putative metal binding site [ion binding]; other site 890402003495 putative phosphate binding site [ion binding]; other site 890402003496 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 890402003497 hypothetical protein; Provisional; Region: PRK02821 890402003498 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 890402003499 G-X-X-G motif; other site 890402003500 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 890402003501 RimM N-terminal domain; Region: RimM; pfam01782 890402003502 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 890402003503 active site 890402003504 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 890402003505 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 890402003506 active site 890402003507 catalytic tetrad [active] 890402003508 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 890402003509 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 890402003510 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 890402003511 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 890402003512 Walker A/P-loop; other site 890402003513 ATP binding site [chemical binding]; other site 890402003514 Q-loop/lid; other site 890402003515 ABC transporter signature motif; other site 890402003516 Walker B; other site 890402003517 D-loop; other site 890402003518 H-loop/switch region; other site 890402003519 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 890402003520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402003521 dimer interface [polypeptide binding]; other site 890402003522 conserved gate region; other site 890402003523 putative PBP binding loops; other site 890402003524 ABC-ATPase subunit interface; other site 890402003525 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 890402003526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402003527 dimer interface [polypeptide binding]; other site 890402003528 conserved gate region; other site 890402003529 putative PBP binding loops; other site 890402003530 ABC-ATPase subunit interface; other site 890402003531 PBP superfamily domain; Region: PBP_like_2; cl17296 890402003532 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 890402003533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 890402003534 active site 890402003535 phosphorylation site [posttranslational modification] 890402003536 intermolecular recognition site; other site 890402003537 dimerization interface [polypeptide binding]; other site 890402003538 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 890402003539 DNA binding site [nucleotide binding] 890402003540 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 890402003541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 890402003542 dimer interface [polypeptide binding]; other site 890402003543 phosphorylation site [posttranslational modification] 890402003544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 890402003545 ATP binding site [chemical binding]; other site 890402003546 Mg2+ binding site [ion binding]; other site 890402003547 G-X-G motif; other site 890402003548 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 890402003549 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 890402003550 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 890402003551 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 890402003552 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 890402003553 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 890402003554 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 890402003555 trimer interface [polypeptide binding]; other site 890402003556 active site 890402003557 G bulge; other site 890402003558 DivIVA protein; Region: DivIVA; pfam05103 890402003559 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 890402003560 putative substrate binding pocket [chemical binding]; other site 890402003561 AC domain interface; other site 890402003562 catalytic triad [active] 890402003563 AB domain interface; other site 890402003564 interchain disulfide; other site 890402003565 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 890402003566 substrate binding site; other site 890402003567 dimer interface; other site 890402003568 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 890402003569 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 890402003570 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 890402003571 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 890402003572 Peptidase family U32; Region: Peptidase_U32; pfam01136 890402003573 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 890402003574 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 890402003575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 890402003576 S-adenosylmethionine binding site [chemical binding]; other site 890402003577 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 890402003578 ssDNA binding site; other site 890402003579 generic binding surface II; other site 890402003580 DEAD-like helicases superfamily; Region: DEXDc; smart00487 890402003581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 890402003582 ATP binding site [chemical binding]; other site 890402003583 putative Mg++ binding site [ion binding]; other site 890402003584 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 890402003585 nucleotide binding region [chemical binding]; other site 890402003586 ATP-binding site [chemical binding]; other site 890402003587 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 890402003588 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 890402003589 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 890402003590 substrate binding site [chemical binding]; other site 890402003591 ATP binding site [chemical binding]; other site 890402003592 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 890402003593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402003594 putative substrate translocation pore; other site 890402003595 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 890402003596 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 890402003597 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 890402003598 DNA binding site [nucleotide binding] 890402003599 active site 890402003600 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 890402003601 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 890402003602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 890402003603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 890402003604 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 890402003605 Aspartase; Region: Aspartase; cd01357 890402003606 active sites [active] 890402003607 tetramer interface [polypeptide binding]; other site 890402003608 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 890402003609 Mechanosensitive ion channel; Region: MS_channel; pfam00924 890402003610 CAAX protease self-immunity; Region: Abi; pfam02517 890402003611 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 890402003612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402003613 Walker A/P-loop; other site 890402003614 ATP binding site [chemical binding]; other site 890402003615 Q-loop/lid; other site 890402003616 ABC transporter signature motif; other site 890402003617 Walker B; other site 890402003618 D-loop; other site 890402003619 H-loop/switch region; other site 890402003620 TOBE domain; Region: TOBE_2; pfam08402 890402003621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402003622 dimer interface [polypeptide binding]; other site 890402003623 conserved gate region; other site 890402003624 putative PBP binding loops; other site 890402003625 ABC-ATPase subunit interface; other site 890402003626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 890402003627 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 890402003628 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 890402003629 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 890402003630 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 890402003631 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 890402003632 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 890402003633 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 890402003634 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 890402003635 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 890402003636 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 890402003637 putative acyl-acceptor binding pocket; other site 890402003638 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 890402003639 homotrimer interaction site [polypeptide binding]; other site 890402003640 putative active site [active] 890402003641 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 890402003642 putative active site [active] 890402003643 putative metal binding residues [ion binding]; other site 890402003644 signature motif; other site 890402003645 putative dimer interface [polypeptide binding]; other site 890402003646 putative phosphate binding site [ion binding]; other site 890402003647 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 890402003648 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 890402003649 hypothetical protein; Provisional; Region: PRK03298 890402003650 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 890402003651 gamma subunit interface [polypeptide binding]; other site 890402003652 epsilon subunit interface [polypeptide binding]; other site 890402003653 LBP interface [polypeptide binding]; other site 890402003654 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 890402003655 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 890402003656 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 890402003657 alpha subunit interaction interface [polypeptide binding]; other site 890402003658 Walker A motif; other site 890402003659 ATP binding site [chemical binding]; other site 890402003660 Walker B motif; other site 890402003661 inhibitor binding site; inhibition site 890402003662 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 890402003663 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 890402003664 core domain interface [polypeptide binding]; other site 890402003665 delta subunit interface [polypeptide binding]; other site 890402003666 epsilon subunit interface [polypeptide binding]; other site 890402003667 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 890402003668 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 890402003669 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 890402003670 beta subunit interaction interface [polypeptide binding]; other site 890402003671 Walker A motif; other site 890402003672 ATP binding site [chemical binding]; other site 890402003673 Walker B motif; other site 890402003674 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 890402003675 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 890402003676 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 890402003677 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 890402003678 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 890402003679 ATP synthase subunit C; Region: ATP-synt_C; cl00466 890402003680 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 890402003681 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 890402003682 homoserine O-succinyltransferase; Provisional; Region: PRK05368 890402003683 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 890402003684 proposed active site lysine [active] 890402003685 conserved cys residue [active] 890402003686 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 890402003687 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 890402003688 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 890402003689 active site 890402003690 homodimer interface [polypeptide binding]; other site 890402003691 catalytic site [active] 890402003692 acceptor binding site [chemical binding]; other site 890402003693 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 890402003694 dimer interface [polypeptide binding]; other site 890402003695 substrate binding site [chemical binding]; other site 890402003696 metal binding sites [ion binding]; metal-binding site 890402003697 Predicted membrane protein [Function unknown]; Region: COG1971 890402003698 Domain of unknown function DUF; Region: DUF204; pfam02659 890402003699 Domain of unknown function DUF; Region: DUF204; pfam02659 890402003700 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 890402003701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 890402003702 DNA binding site [nucleotide binding] 890402003703 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 890402003704 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 890402003705 minor groove reading motif; other site 890402003706 helix-hairpin-helix signature motif; other site 890402003707 substrate binding pocket [chemical binding]; other site 890402003708 active site 890402003709 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 890402003710 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 890402003711 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 890402003712 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 890402003713 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 890402003714 active site 890402003715 HIGH motif; other site 890402003716 nucleotide binding site [chemical binding]; other site 890402003717 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 890402003718 active site 890402003719 KMSKS motif; other site 890402003720 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 890402003721 tRNA binding surface [nucleotide binding]; other site 890402003722 anticodon binding site; other site 890402003723 monofunctional chorismate mutase, alpha proteobacterial type; Region: CM_mono_cladeE; TIGR01795 890402003724 hypothetical protein; Provisional; Region: PRK07208 890402003725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 890402003726 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 890402003727 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 890402003728 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 890402003729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 890402003730 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 890402003731 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 890402003732 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 890402003733 GatB domain; Region: GatB_Yqey; pfam02637 890402003734 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 890402003735 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 890402003736 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 890402003737 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 890402003738 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 890402003739 RmuC family; Region: RmuC; pfam02646 890402003740 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 890402003741 putative homodimer interface [polypeptide binding]; other site 890402003742 putative homotetramer interface [polypeptide binding]; other site 890402003743 putative allosteric switch controlling residues; other site 890402003744 putative metal binding site [ion binding]; other site 890402003745 putative homodimer-homodimer interface [polypeptide binding]; other site 890402003746 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 890402003747 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 890402003748 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 890402003749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 890402003750 active site 890402003751 motif I; other site 890402003752 motif II; other site 890402003753 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 890402003754 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 890402003755 amphipathic channel; other site 890402003756 Asn-Pro-Ala signature motifs; other site 890402003757 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 890402003758 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 890402003759 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 890402003760 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 890402003761 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 890402003762 dimerization domain swap beta strand [polypeptide binding]; other site 890402003763 regulatory protein interface [polypeptide binding]; other site 890402003764 active site 890402003765 regulatory phosphorylation site [posttranslational modification]; other site 890402003766 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 890402003767 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 890402003768 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 890402003769 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 890402003770 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 890402003771 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 890402003772 dimer interface [polypeptide binding]; other site 890402003773 ssDNA binding site [nucleotide binding]; other site 890402003774 tetramer (dimer of dimers) interface [polypeptide binding]; other site 890402003775 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 890402003776 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 890402003777 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 890402003778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 890402003779 active site 890402003780 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 890402003781 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 890402003782 conserved cys residue [active] 890402003783 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 890402003784 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 890402003785 catalytic residue [active] 890402003786 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 890402003787 substrate binding site [chemical binding]; other site 890402003788 active site 890402003789 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 890402003790 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 890402003791 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 890402003792 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 890402003793 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 890402003794 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 890402003795 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 890402003796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 890402003797 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 890402003798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402003799 dimer interface [polypeptide binding]; other site 890402003800 conserved gate region; other site 890402003801 putative PBP binding loops; other site 890402003802 ABC-ATPase subunit interface; other site 890402003803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402003804 dimer interface [polypeptide binding]; other site 890402003805 conserved gate region; other site 890402003806 putative PBP binding loops; other site 890402003807 ABC-ATPase subunit interface; other site 890402003808 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 890402003809 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 890402003810 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402003811 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402003812 DNA binding site [nucleotide binding] 890402003813 domain linker motif; other site 890402003814 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402003815 dimerization interface [polypeptide binding]; other site 890402003816 ligand binding site [chemical binding]; other site 890402003817 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 890402003818 ABC1 family; Region: ABC1; cl17513 890402003819 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 890402003820 Uncharacterized conserved protein [Function unknown]; Region: COG3937 890402003821 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 890402003822 catalytic triad [active] 890402003823 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 890402003824 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 890402003825 replicative DNA helicase; Region: DnaB; TIGR00665 890402003826 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 890402003827 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 890402003828 Walker A motif; other site 890402003829 ATP binding site [chemical binding]; other site 890402003830 Walker B motif; other site 890402003831 DNA binding loops [nucleotide binding] 890402003832 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 890402003833 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 890402003834 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 890402003835 metal binding triad; other site 890402003836 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 890402003837 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 890402003838 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 890402003839 Nitrogen regulatory protein P-II; Region: P-II; smart00938 890402003840 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 890402003841 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 890402003842 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 890402003843 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 890402003844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 890402003845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 890402003846 putative glycosyl transferase; Provisional; Region: PRK10073 890402003847 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 890402003848 active site 890402003849 Peptidase family C69; Region: Peptidase_C69; pfam03577 890402003850 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 890402003851 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 890402003852 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 890402003853 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 890402003854 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 890402003855 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 890402003856 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 890402003857 putative active site [active] 890402003858 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 890402003859 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 890402003860 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 890402003861 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 890402003862 Predicted membrane protein [Function unknown]; Region: COG1511 890402003863 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 890402003864 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 890402003865 Predicted membrane protein [Function unknown]; Region: COG1511 890402003866 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 890402003867 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 890402003868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 890402003869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 890402003870 FMN-binding domain; Region: FMN_bind; cl01081 890402003871 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 890402003872 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 890402003873 Walker A/P-loop; other site 890402003874 ATP binding site [chemical binding]; other site 890402003875 Q-loop/lid; other site 890402003876 ABC transporter signature motif; other site 890402003877 Walker B; other site 890402003878 D-loop; other site 890402003879 H-loop/switch region; other site 890402003880 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 890402003881 FtsX-like permease family; Region: FtsX; pfam02687 890402003882 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 890402003883 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 890402003884 FtsX-like permease family; Region: FtsX; pfam02687 890402003885 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 890402003886 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 890402003887 Fe2+ transport protein; Region: Iron_transport; pfam10634 890402003888 Iron permease FTR1 family; Region: FTR1; cl00475 890402003889 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 890402003890 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 890402003891 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 890402003892 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 890402003893 sugar binding site [chemical binding]; other site 890402003894 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 890402003895 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 890402003896 HIGH motif; other site 890402003897 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 890402003898 active site 890402003899 KMSKS motif; other site 890402003900 Protein of unknown function (DUF805); Region: DUF805; pfam05656 890402003901 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 890402003902 active site 890402003903 phosphate binding residues; other site 890402003904 catalytic residues [active] 890402003905 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 890402003906 catalytic core [active] 890402003907 Predicted membrane protein [Function unknown]; Region: COG2246 890402003908 GtrA-like protein; Region: GtrA; pfam04138 890402003909 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 890402003910 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 890402003911 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 890402003912 Peptidase family C69; Region: Peptidase_C69; pfam03577 890402003913 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 890402003914 substrate binding site [chemical binding]; other site 890402003915 DNA polymerase III subunit delta'; Validated; Region: PRK07940 890402003916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402003917 Walker A motif; other site 890402003918 ATP binding site [chemical binding]; other site 890402003919 Walker B motif; other site 890402003920 thymidylate kinase; Validated; Region: tmk; PRK00698 890402003921 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 890402003922 TMP-binding site; other site 890402003923 ATP-binding site [chemical binding]; other site 890402003924 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 890402003925 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 890402003926 active site 890402003927 interdomain interaction site; other site 890402003928 putative metal-binding site [ion binding]; other site 890402003929 nucleotide binding site [chemical binding]; other site 890402003930 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 890402003931 domain I; other site 890402003932 phosphate binding site [ion binding]; other site 890402003933 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 890402003934 domain II; other site 890402003935 domain III; other site 890402003936 nucleotide binding site [chemical binding]; other site 890402003937 DNA binding groove [nucleotide binding] 890402003938 catalytic site [active] 890402003939 domain IV; other site 890402003940 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 890402003941 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 890402003942 active site 890402003943 Transglycosylase; Region: Transgly; pfam00912 890402003944 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 890402003945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 890402003946 2-isopropylmalate synthase; Validated; Region: PRK03739 890402003947 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 890402003948 active site 890402003949 catalytic residues [active] 890402003950 metal binding site [ion binding]; metal-binding site 890402003951 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 890402003952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 890402003953 Transposase; Region: DDE_Tnp_ISL3; pfam01610 890402003954 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 890402003955 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 890402003956 metal binding site [ion binding]; metal-binding site 890402003957 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 890402003958 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 890402003959 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 890402003960 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 890402003961 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 890402003962 putative allosteric regulatory site; other site 890402003963 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 890402003964 aspartate kinase; Reviewed; Region: PRK06635 890402003965 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 890402003966 putative nucleotide binding site [chemical binding]; other site 890402003967 putative catalytic residues [active] 890402003968 putative Mg ion binding site [ion binding]; other site 890402003969 putative aspartate binding site [chemical binding]; other site 890402003970 AAA domain; Region: AAA_14; pfam13173 890402003971 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 890402003972 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 890402003973 active site 890402003974 catalytic site [active] 890402003975 recombination protein RecR; Reviewed; Region: recR; PRK00076 890402003976 RecR protein; Region: RecR; pfam02132 890402003977 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 890402003978 putative active site [active] 890402003979 putative metal-binding site [ion binding]; other site 890402003980 tetramer interface [polypeptide binding]; other site 890402003981 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 890402003982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402003983 Walker A motif; other site 890402003984 ATP binding site [chemical binding]; other site 890402003985 Walker B motif; other site 890402003986 arginine finger; other site 890402003987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 890402003988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 890402003989 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 890402003990 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 890402003991 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 890402003992 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 890402003993 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 890402003994 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 890402003995 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 890402003996 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 890402003997 ATP binding site [chemical binding]; other site 890402003998 Walker B motif; other site 890402003999 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 890402004000 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 890402004001 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 890402004002 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 890402004003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 890402004004 motif II; other site 890402004005 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 890402004006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 890402004007 NAD(P) binding site [chemical binding]; other site 890402004008 active site 890402004009 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 890402004010 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 890402004011 putative catalytic cysteine [active] 890402004012 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 890402004013 xanthine permease; Region: pbuX; TIGR03173 890402004014 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 890402004015 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 890402004016 DNA binding residues [nucleotide binding] 890402004017 putative dimer interface [polypeptide binding]; other site 890402004018 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 890402004019 HSP70 interaction site [polypeptide binding]; other site 890402004020 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 890402004021 substrate binding site [polypeptide binding]; other site 890402004022 dimer interface [polypeptide binding]; other site 890402004023 GrpE; Region: GrpE; pfam01025 890402004024 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 890402004025 dimer interface [polypeptide binding]; other site 890402004026 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 890402004027 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 890402004028 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 890402004029 nucleotide binding site [chemical binding]; other site 890402004030 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 890402004031 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 890402004032 putative active site [active] 890402004033 putative catalytic site [active] 890402004034 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 890402004035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402004036 ABC-ATPase subunit interface; other site 890402004037 putative PBP binding loops; other site 890402004038 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402004039 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402004040 DNA binding site [nucleotide binding] 890402004041 domain linker motif; other site 890402004042 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402004043 ligand binding site [chemical binding]; other site 890402004044 dimerization interface [polypeptide binding]; other site 890402004045 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 890402004046 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 890402004047 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 890402004048 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 890402004049 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402004050 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402004051 DNA binding site [nucleotide binding] 890402004052 domain linker motif; other site 890402004053 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402004054 ligand binding site [chemical binding]; other site 890402004055 dimerization interface [polypeptide binding]; other site 890402004056 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 890402004057 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 890402004058 active site 890402004059 catalytic site [active] 890402004060 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 890402004061 ketol-acid reductoisomerase; Provisional; Region: PRK05479 890402004062 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 890402004063 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 890402004064 ketol-acid reductoisomerase; Provisional; Region: PRK05479 890402004065 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 890402004066 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 890402004067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402004068 metabolite-proton symporter; Region: 2A0106; TIGR00883 890402004069 putative substrate translocation pore; other site 890402004070 Major Facilitator Superfamily; Region: MFS_1; pfam07690 890402004071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402004072 sucrose phosphorylase; Provisional; Region: PRK13840 890402004073 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 890402004074 active site 890402004075 homodimer interface [polypeptide binding]; other site 890402004076 catalytic site [active] 890402004077 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 890402004078 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402004079 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402004080 DNA binding site [nucleotide binding] 890402004081 domain linker motif; other site 890402004082 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 890402004083 CrcB-like protein; Region: CRCB; pfam02537 890402004084 CrcB-like protein; Region: CRCB; pfam02537 890402004085 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 890402004086 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 890402004087 Cl- binding residues [ion binding]; other site 890402004088 dimer interface [polypeptide binding]; other site 890402004089 TrkA-C domain; Region: TrkA_C; pfam02080 890402004090 putative transposase OrfB; Reviewed; Region: PHA02517 890402004091 HTH-like domain; Region: HTH_21; pfam13276 890402004092 Integrase core domain; Region: rve; pfam00665 890402004093 Integrase core domain; Region: rve_3; pfam13683 890402004094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 890402004095 Transposase; Region: HTH_Tnp_1; cl17663 890402004096 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 890402004097 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 890402004098 Cl- selectivity filter; other site 890402004099 Cl- binding residues [ion binding]; other site 890402004100 pore gating glutamate residue; other site 890402004101 H+/Cl- coupling transport residue; other site 890402004102 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 890402004103 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 890402004104 GDP-binding site [chemical binding]; other site 890402004105 ACT binding site; other site 890402004106 IMP binding site; other site 890402004107 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 890402004108 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 890402004109 active site 890402004110 intersubunit interface [polypeptide binding]; other site 890402004111 zinc binding site [ion binding]; other site 890402004112 Na+ binding site [ion binding]; other site 890402004113 heat shock protein HtpX; Provisional; Region: PRK03072 890402004114 ferredoxin-NADP+ reductase; Region: PLN02852 890402004115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 890402004116 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 890402004117 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 890402004118 Helix-turn-helix domain; Region: HTH_38; pfam13936 890402004119 Integrase core domain; Region: rve; pfam00665 890402004120 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 890402004121 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 890402004122 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 890402004123 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 890402004124 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 890402004125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 890402004126 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 890402004127 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 890402004128 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 890402004129 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402004130 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402004131 DNA binding site [nucleotide binding] 890402004132 domain linker motif; other site 890402004133 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402004134 dimerization interface [polypeptide binding]; other site 890402004135 ligand binding site [chemical binding]; other site 890402004136 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 890402004137 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 890402004138 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 890402004139 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 890402004140 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 890402004141 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 890402004142 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 890402004143 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 890402004144 Haemolysin-III related; Region: HlyIII; cl03831 890402004145 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 890402004146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 890402004147 Coenzyme A binding pocket [chemical binding]; other site 890402004148 hypothetical protein; Provisional; Region: PRK01119 890402004149 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 890402004150 putative DNA-binding cleft [nucleotide binding]; other site 890402004151 putative DNA clevage site; other site 890402004152 molecular lever; other site 890402004153 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 890402004154 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 890402004155 cofactor binding site; other site 890402004156 DNA binding site [nucleotide binding] 890402004157 substrate interaction site [chemical binding]; other site 890402004158 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 890402004159 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 890402004160 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 890402004161 methionine sulfoxide reductase B; Provisional; Region: PRK00222 890402004162 SelR domain; Region: SelR; pfam01641 890402004163 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 890402004164 Putative esterase; Region: Esterase; pfam00756 890402004165 aromatic amino acid exporter; Provisional; Region: PRK11689 890402004166 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 890402004167 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 890402004168 putative dimer interface [polypeptide binding]; other site 890402004169 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 890402004170 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 890402004171 metal ion-dependent adhesion site (MIDAS); other site 890402004172 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 890402004173 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 890402004174 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 890402004175 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 890402004176 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 890402004177 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 890402004178 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 890402004179 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 890402004180 phosphopeptide binding site; other site 890402004181 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 890402004182 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 890402004183 phosphopeptide binding site; other site 890402004184 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 890402004185 active site 890402004186 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 890402004187 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 890402004188 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 890402004189 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 890402004190 active site 890402004191 ATP binding site [chemical binding]; other site 890402004192 substrate binding site [chemical binding]; other site 890402004193 activation loop (A-loop); other site 890402004194 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 890402004195 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 890402004196 active site 890402004197 ATP binding site [chemical binding]; other site 890402004198 substrate binding site [chemical binding]; other site 890402004199 activation loop (A-loop); other site 890402004200 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 890402004201 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 890402004202 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 890402004203 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 890402004204 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 890402004205 Glutamine amidotransferase class-I; Region: GATase; pfam00117 890402004206 glutamine binding [chemical binding]; other site 890402004207 catalytic triad [active] 890402004208 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 890402004209 active site 890402004210 catalytic site [active] 890402004211 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 890402004212 putative septation inhibitor protein; Reviewed; Region: PRK02251 890402004213 Rhomboid family; Region: Rhomboid; pfam01694 890402004214 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 890402004215 homodimer interface [polypeptide binding]; other site 890402004216 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 890402004217 active site pocket [active] 890402004218 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 890402004219 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 890402004220 active site 890402004221 HIGH motif; other site 890402004222 dimer interface [polypeptide binding]; other site 890402004223 KMSKS motif; other site 890402004224 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 890402004225 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 890402004226 active site 890402004227 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 890402004228 Na binding site [ion binding]; other site 890402004229 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 890402004230 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 890402004231 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 890402004232 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 890402004233 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 890402004234 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 890402004235 transposase; Provisional; Region: PRK06526 890402004236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402004237 Walker A motif; other site 890402004238 ATP binding site [chemical binding]; other site 890402004239 Walker B motif; other site 890402004240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 890402004241 Integrase core domain; Region: rve; pfam00665 890402004242 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 890402004243 Divergent AAA domain; Region: AAA_4; pfam04326 890402004244 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 890402004245 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 890402004246 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402004247 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402004248 DNA binding site [nucleotide binding] 890402004249 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402004250 dimerization interface [polypeptide binding]; other site 890402004251 ligand binding site [chemical binding]; other site 890402004252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402004253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 890402004254 putative substrate translocation pore; other site 890402004255 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 890402004256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 890402004257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 890402004258 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 890402004259 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 890402004260 catalytic residues [active] 890402004261 peroxiredoxin; Region: AhpC; TIGR03137 890402004262 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 890402004263 dimer interface [polypeptide binding]; other site 890402004264 decamer (pentamer of dimers) interface [polypeptide binding]; other site 890402004265 catalytic triad [active] 890402004266 peroxidatic and resolving cysteines [active] 890402004267 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 890402004268 active site clefts [active] 890402004269 zinc binding site [ion binding]; other site 890402004270 dimer interface [polypeptide binding]; other site 890402004271 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 890402004272 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 890402004273 Domain of unknown function DUF21; Region: DUF21; pfam01595 890402004274 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 890402004275 Transporter associated domain; Region: CorC_HlyC; smart01091 890402004276 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 890402004277 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 890402004278 dimerization interface [polypeptide binding]; other site 890402004279 DPS ferroxidase diiron center [ion binding]; other site 890402004280 ion pore; other site 890402004281 AAA domain; Region: AAA_14; pfam13173 890402004282 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 890402004283 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 890402004284 Protein of unknown function DUF45; Region: DUF45; pfam01863 890402004285 hypothetical protein; Provisional; Region: PRK06062 890402004286 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 890402004287 inhibitor-cofactor binding pocket; inhibition site 890402004288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402004289 catalytic residue [active] 890402004290 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 890402004291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 890402004292 DNA-binding site [nucleotide binding]; DNA binding site 890402004293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 890402004294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402004295 homodimer interface [polypeptide binding]; other site 890402004296 catalytic residue [active] 890402004297 Transposase; Region: DDE_Tnp_ISL3; pfam01610 890402004298 aspartate aminotransferase; Provisional; Region: PRK05764 890402004299 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 890402004300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402004301 homodimer interface [polypeptide binding]; other site 890402004302 catalytic residue [active] 890402004303 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 890402004304 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 890402004305 putative DNA binding site [nucleotide binding]; other site 890402004306 putative Zn2+ binding site [ion binding]; other site 890402004307 AsnC family; Region: AsnC_trans_reg; pfam01037 890402004308 glutamate dehydrogenase; Provisional; Region: PRK09414 890402004309 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 890402004310 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 890402004311 NAD(P) binding site [chemical binding]; other site 890402004312 putative pectinesterase; Region: PLN02432; cl01911 890402004313 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 890402004314 DNA gyrase subunit A; Validated; Region: PRK05560 890402004315 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 890402004316 CAP-like domain; other site 890402004317 active site 890402004318 primary dimer interface [polypeptide binding]; other site 890402004319 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 890402004320 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 890402004321 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 890402004322 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 890402004323 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 890402004324 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 890402004325 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 890402004326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 890402004327 Mg2+ binding site [ion binding]; other site 890402004328 G-X-G motif; other site 890402004329 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 890402004330 anchoring element; other site 890402004331 dimer interface [polypeptide binding]; other site 890402004332 ATP binding site [chemical binding]; other site 890402004333 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 890402004334 active site 890402004335 putative metal-binding site [ion binding]; other site 890402004336 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 890402004337 Protein of unknown function (DUF721); Region: DUF721; pfam05258 890402004338 recombination protein F; Reviewed; Region: recF; PRK00064 890402004339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402004340 Walker A/P-loop; other site 890402004341 ATP binding site [chemical binding]; other site 890402004342 Q-loop/lid; other site 890402004343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402004344 ABC transporter signature motif; other site 890402004345 Walker B; other site 890402004346 D-loop; other site 890402004347 H-loop/switch region; other site 890402004348 DNA polymerase III subunit beta; Validated; Region: PRK07761 890402004349 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 890402004350 putative DNA binding surface [nucleotide binding]; other site 890402004351 dimer interface [polypeptide binding]; other site 890402004352 beta-clamp/clamp loader binding surface; other site 890402004353 beta-clamp/translesion DNA polymerase binding surface; other site 890402004354 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 890402004355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402004356 Walker A motif; other site 890402004357 ATP binding site [chemical binding]; other site 890402004358 Walker B motif; other site 890402004359 arginine finger; other site 890402004360 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 890402004361 DnaA box-binding interface [nucleotide binding]; other site 890402004362 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 890402004363 Ribonuclease P; Region: Ribonuclease_P; pfam00825 890402004364 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 890402004365 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 890402004366 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 890402004367 G-X-X-G motif; other site 890402004368 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 890402004369 RxxxH motif; other site 890402004370 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 890402004371 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 890402004372 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 890402004373 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 890402004374 P-loop; other site 890402004375 Magnesium ion binding site [ion binding]; other site 890402004376 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 890402004377 Magnesium ion binding site [ion binding]; other site 890402004378 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 890402004379 ParB-like nuclease domain; Region: ParBc; pfam02195 890402004380 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 890402004381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 890402004382 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 890402004383 integral membrane protein MviN; Region: mviN; TIGR01695 890402004384 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 890402004385 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 890402004386 active site 890402004387 Ap6A binding site [chemical binding]; other site 890402004388 nudix motif; other site 890402004389 metal binding site [ion binding]; metal-binding site 890402004390 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 890402004391 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 890402004392 active site 890402004393 NTP binding site [chemical binding]; other site 890402004394 metal binding triad [ion binding]; metal-binding site 890402004395 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 890402004396 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 890402004397 Zn2+ binding site [ion binding]; other site 890402004398 Mg2+ binding site [ion binding]; other site 890402004399 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 890402004400 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 890402004401 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 890402004402 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 890402004403 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 890402004404 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 890402004405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 890402004406 Domain of unknown function (DUF348); Region: DUF348; pfam03990 890402004407 G5 domain; Region: G5; pfam07501 890402004408 Gamma interferon inducible lysosomal thiol reductase (GILT); Region: GILT; pfam03227 890402004409 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 890402004410 Catalytic domain of Protein Kinases; Region: PKc; cd00180 890402004411 active site 890402004412 ATP binding site [chemical binding]; other site 890402004413 substrate binding site [chemical binding]; other site 890402004414 activation loop (A-loop); other site 890402004415 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 890402004416 AAA ATPase domain; Region: AAA_16; pfam13191 890402004417 Ion channel; Region: Ion_trans_2; pfam07885 890402004418 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 890402004419 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 890402004420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 890402004421 non-specific DNA binding site [nucleotide binding]; other site 890402004422 salt bridge; other site 890402004423 sequence-specific DNA binding site [nucleotide binding]; other site 890402004424 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 890402004425 catalytic residues [active] 890402004426 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 890402004427 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 890402004428 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 890402004429 Class I ribonucleotide reductase; Region: RNR_I; cd01679 890402004430 active site 890402004431 dimer interface [polypeptide binding]; other site 890402004432 catalytic residues [active] 890402004433 effector binding site; other site 890402004434 R2 peptide binding site; other site 890402004435 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 890402004436 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 890402004437 dimer interface [polypeptide binding]; other site 890402004438 putative radical transfer pathway; other site 890402004439 diiron center [ion binding]; other site 890402004440 tyrosyl radical; other site 890402004441 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 890402004442 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 890402004443 active site 890402004444 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 890402004445 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 890402004446 Walker A/P-loop; other site 890402004447 ATP binding site [chemical binding]; other site 890402004448 Q-loop/lid; other site 890402004449 ABC transporter signature motif; other site 890402004450 Walker B; other site 890402004451 D-loop; other site 890402004452 H-loop/switch region; other site 890402004453 TOBE domain; Region: TOBE_2; pfam08402 890402004454 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 890402004455 Cna protein B-type domain; Region: Cna_B; pfam05738 890402004456 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 890402004457 active site 890402004458 catalytic site [active] 890402004459 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 890402004460 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 890402004461 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 890402004462 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 890402004463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402004464 Major Facilitator Superfamily; Region: MFS_1; pfam07690 890402004465 putative substrate translocation pore; other site 890402004466 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 890402004467 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 890402004468 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 890402004469 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 890402004470 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 890402004471 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 890402004472 Soluble P-type ATPase [General function prediction only]; Region: COG4087 890402004473 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 890402004474 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 890402004475 trimer interface [polypeptide binding]; other site 890402004476 active site 890402004477 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 890402004478 Serine hydrolase (FSH1); Region: FSH1; pfam03959 890402004479 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 890402004480 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 890402004481 nucleoside/Zn binding site; other site 890402004482 dimer interface [polypeptide binding]; other site 890402004483 catalytic motif [active] 890402004484 Melibiase; Region: Melibiase; pfam02065 890402004485 MarR family; Region: MarR_2; pfam12802 890402004486 Transcriptional regulators [Transcription]; Region: MarR; COG1846 890402004487 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 890402004488 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 890402004489 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 890402004490 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 890402004491 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 890402004492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402004493 dimer interface [polypeptide binding]; other site 890402004494 conserved gate region; other site 890402004495 putative PBP binding loops; other site 890402004496 ABC-ATPase subunit interface; other site 890402004497 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 890402004498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402004499 dimer interface [polypeptide binding]; other site 890402004500 conserved gate region; other site 890402004501 putative PBP binding loops; other site 890402004502 ABC-ATPase subunit interface; other site 890402004503 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 890402004504 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 890402004505 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 890402004506 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 890402004507 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 890402004508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402004509 dimer interface [polypeptide binding]; other site 890402004510 conserved gate region; other site 890402004511 putative PBP binding loops; other site 890402004512 ABC-ATPase subunit interface; other site 890402004513 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 890402004514 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 890402004515 active site 890402004516 catalytic site [active] 890402004517 probable galactinol--sucrose galactosyltransferase 1; Region: PLN02355 890402004518 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 890402004519 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 890402004520 Ca binding site [ion binding]; other site 890402004521 active site 890402004522 catalytic site [active] 890402004523 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 890402004524 tetramer interface [polypeptide binding]; other site 890402004525 threonine dehydratase; Provisional; Region: PRK08198 890402004526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402004527 catalytic residue [active] 890402004528 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 890402004529 NAD-dependent deacetylase; Provisional; Region: PRK00481 890402004530 SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent...; Region: SIRT7; cd01410 890402004531 NAD+ binding site [chemical binding]; other site 890402004532 substrate binding site [chemical binding]; other site 890402004533 Zn binding site [ion binding]; other site 890402004534 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 890402004535 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 890402004536 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 890402004537 Predicted membrane protein [Function unknown]; Region: COG1511 890402004538 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 890402004539 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 890402004540 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 890402004541 dimer interface [polypeptide binding]; other site 890402004542 FMN binding site [chemical binding]; other site 890402004543 NADPH bind site [chemical binding]; other site 890402004544 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 890402004545 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 890402004546 catalytic core [active] 890402004547 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402004548 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402004549 DNA binding site [nucleotide binding] 890402004550 domain linker motif; other site 890402004551 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402004552 ligand binding site [chemical binding]; other site 890402004553 dimerization interface [polypeptide binding]; other site 890402004554 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 890402004555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402004556 putative PBP binding loops; other site 890402004557 dimer interface [polypeptide binding]; other site 890402004558 ABC-ATPase subunit interface; other site 890402004559 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 890402004560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402004561 dimer interface [polypeptide binding]; other site 890402004562 conserved gate region; other site 890402004563 putative PBP binding loops; other site 890402004564 ABC-ATPase subunit interface; other site 890402004565 Protein of unknown function, DUF624; Region: DUF624; pfam04854 890402004566 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 890402004567 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 890402004568 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 890402004569 active site 890402004570 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 890402004571 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 890402004572 active site 890402004573 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 890402004574 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 890402004575 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 890402004576 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 890402004577 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 890402004578 active site 890402004579 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 890402004580 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 890402004581 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 890402004582 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 890402004583 active site 890402004584 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 890402004585 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 890402004586 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 890402004587 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 890402004588 active site 890402004589 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 890402004590 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 890402004591 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 890402004592 active site 890402004593 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 890402004594 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 890402004595 active site 890402004596 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 890402004597 AAA domain; Region: AAA_14; pfam13173 890402004598 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 890402004599 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 890402004600 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 890402004601 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 890402004602 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 890402004603 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 890402004604 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 890402004605 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 890402004606 Walker A/P-loop; other site 890402004607 ATP binding site [chemical binding]; other site 890402004608 Q-loop/lid; other site 890402004609 ABC transporter signature motif; other site 890402004610 Walker B; other site 890402004611 D-loop; other site 890402004612 H-loop/switch region; other site 890402004613 Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795 890402004614 FtsX-like permease family; Region: FtsX; pfam02687 890402004615 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 890402004616 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 890402004617 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 890402004618 Divergent AAA domain; Region: AAA_4; pfam04326 890402004619 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 890402004620 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 890402004621 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 890402004622 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 890402004623 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 890402004624 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 890402004625 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 890402004626 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 890402004627 active site 890402004628 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 890402004629 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 890402004630 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 890402004631 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 890402004632 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 890402004633 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 890402004634 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 890402004635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402004636 Walker A/P-loop; other site 890402004637 ATP binding site [chemical binding]; other site 890402004638 Q-loop/lid; other site 890402004639 ABC transporter signature motif; other site 890402004640 Walker B; other site 890402004641 D-loop; other site 890402004642 H-loop/switch region; other site 890402004643 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 890402004644 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 890402004645 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 890402004646 Walker A/P-loop; other site 890402004647 ATP binding site [chemical binding]; other site 890402004648 Q-loop/lid; other site 890402004649 ABC transporter signature motif; other site 890402004650 Walker B; other site 890402004651 D-loop; other site 890402004652 H-loop/switch region; other site 890402004653 ApbE family; Region: ApbE; pfam02424 890402004654 MFS/sugar transport protein; Region: MFS_2; pfam13347 890402004655 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 890402004656 Predicted methyltransferases [General function prediction only]; Region: COG0313 890402004657 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 890402004658 putative SAM binding site [chemical binding]; other site 890402004659 putative homodimer interface [polypeptide binding]; other site 890402004660 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 890402004661 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 890402004662 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 890402004663 active site 890402004664 HIGH motif; other site 890402004665 KMSKS motif; other site 890402004666 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 890402004667 tRNA binding surface [nucleotide binding]; other site 890402004668 anticodon binding site; other site 890402004669 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 890402004670 trimer interface [polypeptide binding]; other site 890402004671 active site 890402004672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 890402004673 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 890402004674 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 890402004675 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 890402004676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 890402004677 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402004678 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402004679 DNA binding site [nucleotide binding] 890402004680 domain linker motif; other site 890402004681 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402004682 dimerization interface [polypeptide binding]; other site 890402004683 ligand binding site [chemical binding]; other site 890402004684 alpha-galactosidase; Region: PLN02808; cl17638 890402004685 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 890402004686 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 890402004687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402004688 Walker A/P-loop; other site 890402004689 ATP binding site [chemical binding]; other site 890402004690 Q-loop/lid; other site 890402004691 ABC transporter signature motif; other site 890402004692 Walker B; other site 890402004693 D-loop; other site 890402004694 H-loop/switch region; other site 890402004695 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 890402004696 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 890402004697 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 890402004698 Walker A/P-loop; other site 890402004699 ATP binding site [chemical binding]; other site 890402004700 Q-loop/lid; other site 890402004701 ABC transporter signature motif; other site 890402004702 Walker B; other site 890402004703 D-loop; other site 890402004704 H-loop/switch region; other site 890402004705 Fic family protein [Function unknown]; Region: COG3177 890402004706 Fic/DOC family; Region: Fic; pfam02661 890402004707 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 890402004708 active site 890402004709 K+ potassium transporter; Region: K_trans; pfam02705 890402004710 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 890402004711 putative active site [active] 890402004712 putative dimer interface [polypeptide binding]; other site 890402004713 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 890402004714 Zn2+ binding site [ion binding]; other site 890402004715 Mg2+ binding site [ion binding]; other site 890402004716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402004717 ABC transporter; Region: ABC_tran; pfam00005 890402004718 Q-loop/lid; other site 890402004719 ABC transporter signature motif; other site 890402004720 Walker B; other site 890402004721 D-loop; other site 890402004722 H-loop/switch region; other site 890402004723 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 890402004724 FtsX-like permease family; Region: FtsX; pfam02687 890402004725 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 890402004726 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 890402004727 Acyltransferase family; Region: Acyl_transf_3; pfam01757 890402004728 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 890402004729 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 890402004730 Ligand binding site; other site 890402004731 Putative Catalytic site; other site 890402004732 DXD motif; other site 890402004733 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 890402004734 Integrase core domain; Region: rve; pfam00665 890402004735 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 890402004736 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 890402004737 NAD binding site [chemical binding]; other site 890402004738 substrate binding site [chemical binding]; other site 890402004739 homodimer interface [polypeptide binding]; other site 890402004740 active site 890402004741 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 890402004742 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 890402004743 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 890402004744 NADP binding site [chemical binding]; other site 890402004745 active site 890402004746 putative substrate binding site [chemical binding]; other site 890402004747 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 890402004748 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 890402004749 substrate binding site; other site 890402004750 tetramer interface; other site 890402004751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 890402004752 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 890402004753 NAD(P) binding site [chemical binding]; other site 890402004754 active site 890402004755 Acyltransferase family; Region: Acyl_transf_3; pfam01757 890402004756 Rhamnan synthesis protein F; Region: RgpF; pfam05045 890402004757 Rhamnan synthesis protein F; Region: RgpF; pfam05045 890402004758 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 890402004759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 890402004760 active site 890402004761 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 890402004762 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 890402004763 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 890402004764 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 890402004765 Walker A/P-loop; other site 890402004766 ATP binding site [chemical binding]; other site 890402004767 Q-loop/lid; other site 890402004768 ABC transporter signature motif; other site 890402004769 Walker B; other site 890402004770 D-loop; other site 890402004771 H-loop/switch region; other site 890402004772 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 890402004773 putative carbohydrate binding site [chemical binding]; other site 890402004774 Transposase; Region: DDE_Tnp_ISL3; pfam01610 890402004775 putative glycosyl transferase; Provisional; Region: PRK10073 890402004776 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 890402004777 active site 890402004778 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 890402004779 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 890402004780 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 890402004781 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 890402004782 Integrase core domain; Region: rve; pfam00665 890402004783 Transposase; Region: DDE_Tnp_ISL3; pfam01610 890402004784 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 890402004785 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 890402004786 Ligand binding site; other site 890402004787 Putative Catalytic site; other site 890402004788 DXD motif; other site 890402004789 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 890402004790 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 890402004791 UDP-galactopyranose mutase; Region: GLF; pfam03275 890402004792 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 890402004793 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 890402004794 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 890402004795 Transcriptional regulator [Transcription]; Region: IclR; COG1414 890402004796 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 890402004797 Bacterial transcriptional regulator; Region: IclR; pfam01614 890402004798 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 890402004799 active sites [active] 890402004800 tetramer interface [polypeptide binding]; other site 890402004801 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 890402004802 Clp amino terminal domain; Region: Clp_N; pfam02861 890402004803 Clp amino terminal domain; Region: Clp_N; pfam02861 890402004804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402004805 Walker A motif; other site 890402004806 ATP binding site [chemical binding]; other site 890402004807 Walker B motif; other site 890402004808 arginine finger; other site 890402004809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402004810 Walker A motif; other site 890402004811 ATP binding site [chemical binding]; other site 890402004812 Walker B motif; other site 890402004813 arginine finger; other site 890402004814 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 890402004815 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 890402004816 active site 890402004817 HIGH motif; other site 890402004818 nucleotide binding site [chemical binding]; other site 890402004819 active site 890402004820 KMSKS motif; other site 890402004821 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 890402004822 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 890402004823 active site 890402004824 catalytic site [active] 890402004825 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 890402004826 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 890402004827 active site 890402004828 AAA domain; Region: AAA_14; pfam13173 890402004829 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 890402004830 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 890402004831 active site 890402004832 Ap6A binding site [chemical binding]; other site 890402004833 nudix motif; other site 890402004834 metal binding site [ion binding]; metal-binding site 890402004835 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 890402004836 catalytic core [active] 890402004837 polyphosphate kinase; Provisional; Region: PRK05443 890402004838 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 890402004839 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 890402004840 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 890402004841 putative domain interface [polypeptide binding]; other site 890402004842 putative active site [active] 890402004843 catalytic site [active] 890402004844 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 890402004845 putative domain interface [polypeptide binding]; other site 890402004846 putative active site [active] 890402004847 catalytic site [active] 890402004848 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 890402004849 putative active site [active] 890402004850 putative metal binding site [ion binding]; other site 890402004851 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 890402004852 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 890402004853 Transcriptional regulator [Transcription]; Region: IclR; COG1414 890402004854 Bacterial transcriptional regulator; Region: IclR; pfam01614 890402004855 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 890402004856 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 890402004857 substrate binding site [chemical binding]; other site 890402004858 ligand binding site [chemical binding]; other site 890402004859 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 890402004860 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 890402004861 substrate binding site [chemical binding]; other site 890402004862 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 890402004863 active site 890402004864 FMN binding site [chemical binding]; other site 890402004865 substrate binding site [chemical binding]; other site 890402004866 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 890402004867 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 890402004868 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 890402004869 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 890402004870 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 890402004871 hinge; other site 890402004872 active site 890402004873 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 890402004874 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 890402004875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402004876 homodimer interface [polypeptide binding]; other site 890402004877 catalytic residue [active] 890402004878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 890402004879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 890402004880 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 890402004881 putative dimerization interface [polypeptide binding]; other site 890402004882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402004883 Major Facilitator Superfamily; Region: MFS_1; pfam07690 890402004884 putative substrate translocation pore; other site 890402004885 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 890402004886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 890402004887 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 890402004888 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 890402004889 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 890402004890 active site 890402004891 HIGH motif; other site 890402004892 nucleotide binding site [chemical binding]; other site 890402004893 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 890402004894 KMSK motif region; other site 890402004895 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 890402004896 tRNA binding surface [nucleotide binding]; other site 890402004897 anticodon binding site; other site 890402004898 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 890402004899 catalytic residue [active] 890402004900 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 890402004901 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 890402004902 homoserine dehydrogenase; Provisional; Region: PRK06349 890402004903 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 890402004904 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 890402004905 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 890402004906 homoserine kinase; Provisional; Region: PRK01212 890402004907 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 890402004908 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 890402004909 putative active site [active] 890402004910 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 890402004911 dimer interface [polypeptide binding]; other site 890402004912 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 890402004913 nudix motif; other site 890402004914 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 890402004915 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 890402004916 Walker A/P-loop; other site 890402004917 ATP binding site [chemical binding]; other site 890402004918 Q-loop/lid; other site 890402004919 ABC transporter signature motif; other site 890402004920 Walker B; other site 890402004921 D-loop; other site 890402004922 H-loop/switch region; other site 890402004923 Predicted permeases [General function prediction only]; Region: COG0679 890402004924 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 890402004925 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 890402004926 metal binding site [ion binding]; metal-binding site 890402004927 putative dimer interface [polypeptide binding]; other site 890402004928 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 890402004929 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 890402004930 homodimer interface [polypeptide binding]; other site 890402004931 oligonucleotide binding site [chemical binding]; other site 890402004932 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 890402004933 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 890402004934 GTPase CgtA; Reviewed; Region: obgE; PRK12296 890402004935 GTP1/OBG; Region: GTP1_OBG; pfam01018 890402004936 Obg GTPase; Region: Obg; cd01898 890402004937 G1 box; other site 890402004938 GTP/Mg2+ binding site [chemical binding]; other site 890402004939 Switch I region; other site 890402004940 G2 box; other site 890402004941 G3 box; other site 890402004942 Switch II region; other site 890402004943 G4 box; other site 890402004944 G5 box; other site 890402004945 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 890402004946 gamma-glutamyl kinase; Provisional; Region: PRK05429 890402004947 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 890402004948 nucleotide binding site [chemical binding]; other site 890402004949 homotetrameric interface [polypeptide binding]; other site 890402004950 putative phosphate binding site [ion binding]; other site 890402004951 putative allosteric binding site; other site 890402004952 PUA domain; Region: PUA; pfam01472 890402004953 aspartate aminotransferase; Provisional; Region: PRK05764 890402004954 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 890402004955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402004956 homodimer interface [polypeptide binding]; other site 890402004957 catalytic residue [active] 890402004958 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 890402004959 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 890402004960 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 890402004961 putative homodimer interface [polypeptide binding]; other site 890402004962 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 890402004963 heterodimer interface [polypeptide binding]; other site 890402004964 homodimer interface [polypeptide binding]; other site 890402004965 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 890402004966 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 890402004967 23S rRNA interface [nucleotide binding]; other site 890402004968 L7/L12 interface [polypeptide binding]; other site 890402004969 putative thiostrepton binding site; other site 890402004970 L25 interface [polypeptide binding]; other site 890402004971 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 890402004972 mRNA/rRNA interface [nucleotide binding]; other site 890402004973 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 890402004974 Bacterial transcriptional regulator; Region: IclR; pfam01614 890402004975 Transcriptional regulator [Transcription]; Region: IclR; COG1414 890402004976 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 890402004977 Bacterial transcriptional regulator; Region: IclR; pfam01614 890402004978 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 890402004979 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 890402004980 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 890402004981 BioY family; Region: BioY; pfam02632 890402004982 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 890402004983 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 890402004984 ATP-grasp domain; Region: ATP-grasp_4; cl17255 890402004985 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 890402004986 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 890402004987 carboxyltransferase (CT) interaction site; other site 890402004988 biotinylation site [posttranslational modification]; other site 890402004989 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 890402004990 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 890402004991 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 890402004992 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 890402004993 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 890402004994 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 890402004995 phosphate binding site [ion binding]; other site 890402004996 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 890402004997 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 890402004998 putative active site [active] 890402004999 putative catalytic site [active] 890402005000 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 890402005001 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 890402005002 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 890402005003 putative NAD(P) binding site [chemical binding]; other site 890402005004 active site 890402005005 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 890402005006 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 890402005007 active site 890402005008 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402005009 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402005010 DNA binding site [nucleotide binding] 890402005011 domain linker motif; other site 890402005012 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 890402005013 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402005014 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 890402005015 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 890402005016 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 890402005017 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 890402005018 active site 890402005019 catalytic site [active] 890402005020 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 890402005021 metal ion-dependent adhesion site (MIDAS); other site 890402005022 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 890402005023 domain interaction interfaces [polypeptide binding]; other site 890402005024 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 890402005025 Integrase core domain; Region: rve; pfam00665 890402005026 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 890402005027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402005028 Walker A/P-loop; other site 890402005029 ATP binding site [chemical binding]; other site 890402005030 ABC transporter; Region: ABC_tran; pfam00005 890402005031 Q-loop/lid; other site 890402005032 Walker B; other site 890402005033 D-loop; other site 890402005034 H-loop/switch region; other site 890402005035 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 890402005036 Integrase core domain; Region: rve; pfam00665 890402005037 Integrase core domain; Region: rve_3; cl15866 890402005038 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 890402005039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 890402005040 DNA-binding interface [nucleotide binding]; DNA binding site 890402005041 Integrase core domain; Region: rve; pfam00665 890402005042 transposase/IS protein; Provisional; Region: PRK09183 890402005043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402005044 Walker A motif; other site 890402005045 ATP binding site [chemical binding]; other site 890402005046 Walker B motif; other site 890402005047 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 890402005048 Helix-turn-helix domain; Region: HTH_38; pfam13936 890402005049 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 890402005050 substrate binding site [chemical binding]; other site 890402005051 active site 890402005052 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 890402005053 metal binding site [ion binding]; metal-binding site 890402005054 ligand binding site [chemical binding]; other site 890402005055 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 890402005056 active site 890402005057 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 890402005058 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 890402005059 16S/18S rRNA binding site [nucleotide binding]; other site 890402005060 S13e-L30e interaction site [polypeptide binding]; other site 890402005061 25S rRNA binding site [nucleotide binding]; other site 890402005062 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 890402005063 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 890402005064 oligomer interface [polypeptide binding]; other site 890402005065 RNA binding site [nucleotide binding]; other site 890402005066 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 890402005067 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 890402005068 RNase E interface [polypeptide binding]; other site 890402005069 trimer interface [polypeptide binding]; other site 890402005070 active site 890402005071 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 890402005072 putative nucleic acid binding region [nucleotide binding]; other site 890402005073 G-X-X-G motif; other site 890402005074 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 890402005075 RNA binding site [nucleotide binding]; other site 890402005076 domain interface; other site 890402005077 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 890402005078 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 890402005079 23S rRNA interface [nucleotide binding]; other site 890402005080 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 890402005081 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 890402005082 peripheral dimer interface [polypeptide binding]; other site 890402005083 core dimer interface [polypeptide binding]; other site 890402005084 L10 interface [polypeptide binding]; other site 890402005085 L11 interface [polypeptide binding]; other site 890402005086 putative EF-Tu interaction site [polypeptide binding]; other site 890402005087 putative EF-G interaction site [polypeptide binding]; other site 890402005088 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 890402005089 phosphopeptide binding site; other site 890402005090 Part of AAA domain; Region: AAA_19; pfam13245 890402005091 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 890402005092 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 890402005093 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 890402005094 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 890402005095 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 890402005096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 890402005097 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 890402005098 oligomerisation interface [polypeptide binding]; other site 890402005099 mobile loop; other site 890402005100 roof hairpin; other site 890402005101 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 890402005102 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 890402005103 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 890402005104 catalytic residue [active] 890402005105 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 890402005106 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 890402005107 FAD binding domain; Region: FAD_binding_4; pfam01565 890402005108 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 890402005109 amino acid transporter; Region: 2A0306; TIGR00909 890402005110 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 890402005111 Ferredoxin [Energy production and conversion]; Region: COG1146 890402005112 4Fe-4S binding domain; Region: Fer4; pfam00037 890402005113 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 890402005114 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 890402005115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402005116 homodimer interface [polypeptide binding]; other site 890402005117 catalytic residue [active] 890402005118 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402005119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402005120 DNA binding site [nucleotide binding] 890402005121 domain linker motif; other site 890402005122 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402005123 ligand binding site [chemical binding]; other site 890402005124 dimerization interface [polypeptide binding]; other site 890402005125 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 890402005126 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 890402005127 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 890402005128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402005129 dimer interface [polypeptide binding]; other site 890402005130 conserved gate region; other site 890402005131 putative PBP binding loops; other site 890402005132 ABC-ATPase subunit interface; other site 890402005133 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 890402005134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402005135 dimer interface [polypeptide binding]; other site 890402005136 conserved gate region; other site 890402005137 putative PBP binding loops; other site 890402005138 ABC-ATPase subunit interface; other site 890402005139 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 890402005140 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 890402005141 Ca binding site [ion binding]; other site 890402005142 active site 890402005143 catalytic site [active] 890402005144 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 890402005145 DNA polymerase IV; Validated; Region: PRK03858 890402005146 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 890402005147 active site 890402005148 DNA binding site [nucleotide binding] 890402005149 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 890402005150 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 890402005151 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 890402005152 putative active site [active] 890402005153 putative metal binding site [ion binding]; other site 890402005154 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 890402005155 dimerization interface [polypeptide binding]; other site 890402005156 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 890402005157 NAD binding site [chemical binding]; other site 890402005158 ligand binding site [chemical binding]; other site 890402005159 catalytic site [active] 890402005160 Uncharacterized conserved protein [Function unknown]; Region: COG1739 890402005161 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 890402005162 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 890402005163 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 890402005164 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 890402005165 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 890402005166 23S rRNA interface [nucleotide binding]; other site 890402005167 L3 interface [polypeptide binding]; other site 890402005168 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 890402005169 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 890402005170 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 890402005171 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 890402005172 active site 890402005173 catalytic site [active] 890402005174 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 890402005175 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 890402005176 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 890402005177 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 890402005178 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 890402005179 putative catalytic cysteine [active] 890402005180 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 890402005181 putative active site [active] 890402005182 metal binding site [ion binding]; metal-binding site 890402005183 YwiC-like protein; Region: YwiC; pfam14256 890402005184 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 890402005185 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 890402005186 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 890402005187 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 890402005188 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 890402005189 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 890402005190 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 890402005191 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 890402005192 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 890402005193 putative translocon binding site; other site 890402005194 protein-rRNA interface [nucleotide binding]; other site 890402005195 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 890402005196 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 890402005197 G-X-X-G motif; other site 890402005198 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 890402005199 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 890402005200 23S rRNA interface [nucleotide binding]; other site 890402005201 5S rRNA interface [nucleotide binding]; other site 890402005202 putative antibiotic binding site [chemical binding]; other site 890402005203 L25 interface [polypeptide binding]; other site 890402005204 L27 interface [polypeptide binding]; other site 890402005205 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 890402005206 23S rRNA interface [nucleotide binding]; other site 890402005207 putative translocon interaction site; other site 890402005208 signal recognition particle (SRP54) interaction site; other site 890402005209 L23 interface [polypeptide binding]; other site 890402005210 trigger factor interaction site; other site 890402005211 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 890402005212 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 890402005213 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 890402005214 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 890402005215 RNA binding site [nucleotide binding]; other site 890402005216 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 890402005217 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 890402005218 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 890402005219 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 890402005220 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 890402005221 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 890402005222 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 890402005223 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 890402005224 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 890402005225 23S rRNA interface [nucleotide binding]; other site 890402005226 L21e interface [polypeptide binding]; other site 890402005227 5S rRNA interface [nucleotide binding]; other site 890402005228 L27 interface [polypeptide binding]; other site 890402005229 L5 interface [polypeptide binding]; other site 890402005230 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 890402005231 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 890402005232 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 890402005233 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 890402005234 23S rRNA binding site [nucleotide binding]; other site 890402005235 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 890402005236 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 890402005237 SecY translocase; Region: SecY; pfam00344 890402005238 adenylate kinase; Reviewed; Region: adk; PRK00279 890402005239 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 890402005240 AMP-binding site [chemical binding]; other site 890402005241 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 890402005242 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 890402005243 rRNA binding site [nucleotide binding]; other site 890402005244 predicted 30S ribosome binding site; other site 890402005245 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 890402005246 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 890402005247 30S ribosomal protein S13; Region: bact_S13; TIGR03631 890402005248 30S ribosomal protein S11; Validated; Region: PRK05309 890402005249 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 890402005250 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 890402005251 alphaNTD homodimer interface [polypeptide binding]; other site 890402005252 alphaNTD - beta interaction site [polypeptide binding]; other site 890402005253 alphaNTD - beta' interaction site [polypeptide binding]; other site 890402005254 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 890402005255 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 890402005256 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 890402005257 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 890402005258 dimerization interface 3.5A [polypeptide binding]; other site 890402005259 active site 890402005260 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 890402005261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 890402005262 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 890402005263 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 890402005264 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 890402005265 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 890402005266 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 890402005267 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402005268 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402005269 DNA binding site [nucleotide binding] 890402005270 domain linker motif; other site 890402005271 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402005272 dimerization interface [polypeptide binding]; other site 890402005273 ligand binding site [chemical binding]; other site 890402005274 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 890402005275 NusA N-terminal domain; Region: NusA_N; pfam08529 890402005276 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 890402005277 RNA binding site [nucleotide binding]; other site 890402005278 homodimer interface [polypeptide binding]; other site 890402005279 NusA-like KH domain; Region: KH_5; pfam13184 890402005280 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 890402005281 G-X-X-G motif; other site 890402005282 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 890402005283 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 890402005284 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 890402005285 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 890402005286 G1 box; other site 890402005287 putative GEF interaction site [polypeptide binding]; other site 890402005288 GTP/Mg2+ binding site [chemical binding]; other site 890402005289 Switch I region; other site 890402005290 G2 box; other site 890402005291 G3 box; other site 890402005292 Switch II region; other site 890402005293 G4 box; other site 890402005294 G5 box; other site 890402005295 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 890402005296 Translation-initiation factor 2; Region: IF-2; pfam11987 890402005297 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 890402005298 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 890402005299 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 890402005300 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 890402005301 RNA binding site [nucleotide binding]; other site 890402005302 active site 890402005303 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 890402005304 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 890402005305 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 890402005306 active site 890402005307 Riboflavin kinase; Region: Flavokinase; pfam01687 890402005308 AAA domain; Region: AAA_25; pfam13481 890402005309 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 890402005310 Walker A motif; other site 890402005311 ATP binding site [chemical binding]; other site 890402005312 Walker B motif; other site 890402005313 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 890402005314 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 890402005315 tetramer (dimer of dimers) interface [polypeptide binding]; other site 890402005316 active site 890402005317 dimer interface [polypeptide binding]; other site 890402005318 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 890402005319 RNA/DNA hybrid binding site [nucleotide binding]; other site 890402005320 active site 890402005321 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 890402005322 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 890402005323 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 890402005324 Transcriptional regulator; Region: Rrf2; pfam02082 890402005325 Rrf2 family protein; Region: rrf2_super; TIGR00738 890402005326 phosphoglucomutase; Validated; Region: PRK07564 890402005327 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 890402005328 active site 890402005329 substrate binding site [chemical binding]; other site 890402005330 metal binding site [ion binding]; metal-binding site 890402005331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402005332 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 890402005333 putative substrate translocation pore; other site 890402005334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402005335 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 890402005336 active site turn [active] 890402005337 phosphorylation site [posttranslational modification] 890402005338 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 890402005339 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 890402005340 HPr interaction site; other site 890402005341 glycerol kinase (GK) interaction site [polypeptide binding]; other site 890402005342 active site 890402005343 phosphorylation site [posttranslational modification] 890402005344 transcriptional antiterminator BglG; Provisional; Region: PRK09772 890402005345 CAT RNA binding domain; Region: CAT_RBD; smart01061 890402005346 PRD domain; Region: PRD; pfam00874 890402005347 PRD domain; Region: PRD; pfam00874 890402005348 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 890402005349 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 890402005350 seryl-tRNA synthetase; Provisional; Region: PRK05431 890402005351 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 890402005352 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 890402005353 dimer interface [polypeptide binding]; other site 890402005354 active site 890402005355 motif 1; other site 890402005356 motif 2; other site 890402005357 motif 3; other site 890402005358 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 890402005359 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 890402005360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402005361 dimer interface [polypeptide binding]; other site 890402005362 conserved gate region; other site 890402005363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 890402005364 ABC-ATPase subunit interface; other site 890402005365 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 890402005366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 890402005367 dimer interface [polypeptide binding]; other site 890402005368 conserved gate region; other site 890402005369 putative PBP binding loops; other site 890402005370 ABC-ATPase subunit interface; other site 890402005371 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 890402005372 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 890402005373 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 890402005374 Phosphotransferase enzyme family; Region: APH; pfam01636 890402005375 active site 890402005376 substrate binding site [chemical binding]; other site 890402005377 ATP binding site [chemical binding]; other site 890402005378 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 890402005379 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 890402005380 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 890402005381 UDP-glucose 4-epimerase; Region: PLN02240 890402005382 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 890402005383 NAD binding site [chemical binding]; other site 890402005384 homodimer interface [polypeptide binding]; other site 890402005385 active site 890402005386 substrate binding site [chemical binding]; other site 890402005387 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 890402005388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 890402005389 active site 890402005390 phosphorylation site [posttranslational modification] 890402005391 intermolecular recognition site; other site 890402005392 dimerization interface [polypeptide binding]; other site 890402005393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 890402005394 DNA binding residues [nucleotide binding] 890402005395 dimerization interface [polypeptide binding]; other site 890402005396 PspC domain; Region: PspC; pfam04024 890402005397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 890402005398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 890402005399 ATP binding site [chemical binding]; other site 890402005400 Mg2+ binding site [ion binding]; other site 890402005401 G-X-G motif; other site 890402005402 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 890402005403 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 890402005404 Tetratricopeptide repeat; Region: TPR_12; pfam13424 890402005405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 890402005406 binding surface 890402005407 TPR motif; other site 890402005408 Tetratricopeptide repeat; Region: TPR_12; pfam13424 890402005409 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 890402005410 MFS transport protein AraJ; Provisional; Region: PRK10091 890402005411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402005412 putative substrate translocation pore; other site 890402005413 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 890402005414 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 890402005415 dimer interface [polypeptide binding]; other site 890402005416 putative anticodon binding site; other site 890402005417 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 890402005418 motif 1; other site 890402005419 dimer interface [polypeptide binding]; other site 890402005420 active site 890402005421 motif 2; other site 890402005422 motif 3; other site 890402005423 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 890402005424 UbiA prenyltransferase family; Region: UbiA; pfam01040 890402005425 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 890402005426 catalytic core [active] 890402005427 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 890402005428 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 890402005429 PhoU domain; Region: PhoU; pfam01895 890402005430 PhoU domain; Region: PhoU; pfam01895 890402005431 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 890402005432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 890402005433 ATP binding site [chemical binding]; other site 890402005434 Mg2+ binding site [ion binding]; other site 890402005435 G-X-G motif; other site 890402005436 phosphoserine aminotransferase; Provisional; Region: PRK03080 890402005437 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 890402005438 catalytic residue [active] 890402005439 CHAP domain; Region: CHAP; pfam05257 890402005440 NlpC/P60 family; Region: NLPC_P60; cl17555 890402005441 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 890402005442 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 890402005443 NlpC/P60 family; Region: NLPC_P60; pfam00877 890402005444 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 890402005445 Ligand Binding Site [chemical binding]; other site 890402005446 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 890402005447 Ligand Binding Site [chemical binding]; other site 890402005448 OsmC-like protein; Region: OsmC; pfam02566 890402005449 thymidylate synthase; Reviewed; Region: thyA; PRK01827 890402005450 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 890402005451 dimerization interface [polypeptide binding]; other site 890402005452 active site 890402005453 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 890402005454 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 890402005455 folate binding site [chemical binding]; other site 890402005456 NADP+ binding site [chemical binding]; other site 890402005457 Low molecular weight phosphatase family; Region: LMWPc; cd00115 890402005458 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 890402005459 active site 890402005460 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 890402005461 AzlC protein; Region: AzlC; cl00570 890402005462 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 890402005463 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 890402005464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 890402005465 NAD(P) binding site [chemical binding]; other site 890402005466 active site 890402005467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402005468 Major Facilitator Superfamily; Region: MFS_1; pfam07690 890402005469 putative substrate translocation pore; other site 890402005470 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 890402005471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 890402005472 S-adenosylmethionine binding site [chemical binding]; other site 890402005473 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 890402005474 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 890402005475 dimer interface [polypeptide binding]; other site 890402005476 active site 890402005477 metal binding site [ion binding]; metal-binding site 890402005478 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 890402005479 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 890402005480 active site 890402005481 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 890402005482 Domain of unknown function DUF20; Region: UPF0118; pfam01594 890402005483 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 890402005484 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 890402005485 DXD motif; other site 890402005486 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 890402005487 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 890402005488 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 890402005489 Walker A/P-loop; other site 890402005490 ATP binding site [chemical binding]; other site 890402005491 Q-loop/lid; other site 890402005492 ABC transporter signature motif; other site 890402005493 Walker B; other site 890402005494 D-loop; other site 890402005495 H-loop/switch region; other site 890402005496 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 890402005497 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 890402005498 Ligand Binding Site [chemical binding]; other site 890402005499 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 890402005500 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 890402005501 active site 890402005502 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 890402005503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402005504 Walker A motif; other site 890402005505 ATP binding site [chemical binding]; other site 890402005506 Walker B motif; other site 890402005507 arginine finger; other site 890402005508 Peptidase family M41; Region: Peptidase_M41; pfam01434 890402005509 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 890402005510 GTP cyclohydrolase I; Provisional; Region: PLN03044 890402005511 active site 890402005512 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 890402005513 dihydropteroate synthase; Region: DHPS; TIGR01496 890402005514 substrate binding pocket [chemical binding]; other site 890402005515 dimer interface [polypeptide binding]; other site 890402005516 inhibitor binding site; inhibition site 890402005517 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 890402005518 homooctamer interface [polypeptide binding]; other site 890402005519 active site 890402005520 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 890402005521 catalytic center binding site [active] 890402005522 ATP binding site [chemical binding]; other site 890402005523 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 890402005524 catalytic center binding site [active] 890402005525 ATP binding site [chemical binding]; other site 890402005526 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 890402005527 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 890402005528 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 890402005529 active site 890402005530 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 890402005531 catalytic triad [active] 890402005532 dimer interface [polypeptide binding]; other site 890402005533 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 890402005534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402005535 Walker A/P-loop; other site 890402005536 ATP binding site [chemical binding]; other site 890402005537 Q-loop/lid; other site 890402005538 ABC transporter signature motif; other site 890402005539 Walker B; other site 890402005540 D-loop; other site 890402005541 H-loop/switch region; other site 890402005542 ABC transporter; Region: ABC_tran_2; pfam12848 890402005543 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 890402005544 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 890402005545 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 890402005546 nucleotide binding site [chemical binding]; other site 890402005547 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 890402005548 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 890402005549 Walker A/P-loop; other site 890402005550 ATP binding site [chemical binding]; other site 890402005551 Q-loop/lid; other site 890402005552 ABC transporter signature motif; other site 890402005553 Walker B; other site 890402005554 D-loop; other site 890402005555 H-loop/switch region; other site 890402005556 MarR family; Region: MarR_2; pfam12802 890402005557 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 890402005558 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 890402005559 nucleotide binding site [chemical binding]; other site 890402005560 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 890402005561 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 890402005562 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 890402005563 putative ligand binding site [chemical binding]; other site 890402005564 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 890402005565 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 890402005566 Walker A/P-loop; other site 890402005567 ATP binding site [chemical binding]; other site 890402005568 Q-loop/lid; other site 890402005569 ABC transporter signature motif; other site 890402005570 Walker B; other site 890402005571 D-loop; other site 890402005572 H-loop/switch region; other site 890402005573 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 890402005574 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 890402005575 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 890402005576 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 890402005577 TM-ABC transporter signature motif; other site 890402005578 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 890402005579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402005580 putative substrate translocation pore; other site 890402005581 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 890402005582 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 890402005583 active site 890402005584 catalytic tetrad [active] 890402005585 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 890402005586 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 890402005587 xylose isomerase; Provisional; Region: PRK05474 890402005588 xylose isomerase; Region: xylose_isom_A; TIGR02630 890402005589 Transposase, Mutator family; Region: Transposase_mut; pfam00872 890402005590 MULE transposase domain; Region: MULE; pfam10551 890402005591 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 890402005592 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 890402005593 N- and C-terminal domain interface [polypeptide binding]; other site 890402005594 D-xylulose kinase; Region: XylB; TIGR01312 890402005595 active site 890402005596 MgATP binding site [chemical binding]; other site 890402005597 catalytic site [active] 890402005598 metal binding site [ion binding]; metal-binding site 890402005599 xylulose binding site [chemical binding]; other site 890402005600 putative homodimer interface [polypeptide binding]; other site 890402005601 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 890402005602 non-specific DNA interactions [nucleotide binding]; other site 890402005603 DNA binding site [nucleotide binding] 890402005604 sequence specific DNA binding site [nucleotide binding]; other site 890402005605 putative cAMP binding site [chemical binding]; other site 890402005606 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 890402005607 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 890402005608 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 890402005609 peptide chain release factor 1; Validated; Region: prfA; PRK00591 890402005610 This domain is found in peptide chain release factors; Region: PCRF; smart00937 890402005611 RF-1 domain; Region: RF-1; pfam00472 890402005612 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 890402005613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 890402005614 S-adenosylmethionine binding site [chemical binding]; other site 890402005615 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 890402005616 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 890402005617 putative ligand binding site [chemical binding]; other site 890402005618 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 890402005619 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 890402005620 TM-ABC transporter signature motif; other site 890402005621 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 890402005622 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 890402005623 TM-ABC transporter signature motif; other site 890402005624 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 890402005625 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 890402005626 Walker A/P-loop; other site 890402005627 ATP binding site [chemical binding]; other site 890402005628 Q-loop/lid; other site 890402005629 ABC transporter signature motif; other site 890402005630 Walker B; other site 890402005631 D-loop; other site 890402005632 H-loop/switch region; other site 890402005633 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 890402005634 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 890402005635 Walker A/P-loop; other site 890402005636 ATP binding site [chemical binding]; other site 890402005637 Q-loop/lid; other site 890402005638 ABC transporter signature motif; other site 890402005639 Walker B; other site 890402005640 D-loop; other site 890402005641 H-loop/switch region; other site 890402005642 maltose O-acetyltransferase; Provisional; Region: PRK10092 890402005643 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 890402005644 active site 890402005645 substrate binding site [chemical binding]; other site 890402005646 trimer interface [polypeptide binding]; other site 890402005647 CoA binding site [chemical binding]; other site 890402005648 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 890402005649 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 890402005650 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 890402005651 Mg++ binding site [ion binding]; other site 890402005652 putative catalytic motif [active] 890402005653 substrate binding site [chemical binding]; other site 890402005654 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 890402005655 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 890402005656 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 890402005657 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 890402005658 active site 890402005659 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 890402005660 catalytic site [active] 890402005661 putative active site [active] 890402005662 putative substrate binding site [chemical binding]; other site 890402005663 dimer interface [polypeptide binding]; other site 890402005664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 890402005665 PIF1-like helicase; Region: PIF1; pfam05970 890402005666 Walker A motif; other site 890402005667 ATP binding site [chemical binding]; other site 890402005668 Walker B motif; other site 890402005669 arginine finger; other site 890402005670 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 890402005671 putative ligand binding pocket/active site [active] 890402005672 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 890402005673 AMMECR1; Region: AMMECR1; pfam01871 890402005674 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 890402005675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 890402005676 FeS/SAM binding site; other site 890402005677 prolyl-tRNA synthetase; Provisional; Region: PRK09194 890402005678 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 890402005679 dimer interface [polypeptide binding]; other site 890402005680 motif 1; other site 890402005681 active site 890402005682 motif 2; other site 890402005683 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 890402005684 putative deacylase active site [active] 890402005685 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 890402005686 active site 890402005687 motif 3; other site 890402005688 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 890402005689 anticodon binding site; other site 890402005690 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 890402005691 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 890402005692 dimer interface [polypeptide binding]; other site 890402005693 ssDNA binding site [nucleotide binding]; other site 890402005694 tetramer (dimer of dimers) interface [polypeptide binding]; other site 890402005695 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 890402005696 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 890402005697 active site 890402005698 Zn binding site [ion binding]; other site 890402005699 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 890402005700 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 890402005701 active site 890402005702 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 890402005703 Citrate synthase; Region: Citrate_synt; pfam00285 890402005704 oxalacetate binding site [chemical binding]; other site 890402005705 citrylCoA binding site [chemical binding]; other site 890402005706 coenzyme A binding site [chemical binding]; other site 890402005707 catalytic triad [active] 890402005708 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 890402005709 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 890402005710 putative trimer interface [polypeptide binding]; other site 890402005711 putative CoA binding site [chemical binding]; other site 890402005712 Penicillinase repressor; Region: Pencillinase_R; cl17580 890402005713 WYL domain; Region: WYL; pfam13280 890402005714 SWIM zinc finger; Region: SWIM; pfam04434 890402005715 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 890402005716 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 890402005717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 890402005718 ATP binding site [chemical binding]; other site 890402005719 putative Mg++ binding site [ion binding]; other site 890402005720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 890402005721 nucleotide binding region [chemical binding]; other site 890402005722 ATP-binding site [chemical binding]; other site 890402005723 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 890402005724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 890402005725 Coenzyme A binding pocket [chemical binding]; other site 890402005726 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 890402005727 additional DNA contacts [nucleotide binding]; other site 890402005728 mismatch recognition site; other site 890402005729 active site 890402005730 zinc binding site [ion binding]; other site 890402005731 DNA intercalation site [nucleotide binding]; other site 890402005732 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 890402005733 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 890402005734 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 890402005735 hypothetical protein; Provisional; Region: PRK08960 890402005736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 890402005737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402005738 homodimer interface [polypeptide binding]; other site 890402005739 catalytic residue [active] 890402005740 exopolyphosphatase; Region: exo_poly_only; TIGR03706 890402005741 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 890402005742 nucleotide binding site [chemical binding]; other site 890402005743 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 890402005744 putative catalytic site [active] 890402005745 putative metal binding site [ion binding]; other site 890402005746 putative phosphate binding site [ion binding]; other site 890402005747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 890402005748 Coenzyme A binding pocket [chemical binding]; other site 890402005749 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 890402005750 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 890402005751 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 890402005752 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 890402005753 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 890402005754 acyl-activating enzyme (AAE) consensus motif; other site 890402005755 putative AMP binding site [chemical binding]; other site 890402005756 putative active site [active] 890402005757 putative CoA binding site [chemical binding]; other site 890402005758 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 890402005759 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 890402005760 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 890402005761 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 890402005762 generic binding surface II; other site 890402005763 generic binding surface I; other site 890402005764 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 890402005765 ATP cone domain; Region: ATP-cone; pfam03477 890402005766 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 890402005767 Class III ribonucleotide reductase; Region: RNR_III; cd01675 890402005768 active site 890402005769 Zn binding site [ion binding]; other site 890402005770 glycine loop; other site 890402005771 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 890402005772 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 890402005773 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 890402005774 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 890402005775 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 890402005776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 890402005777 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 890402005778 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 890402005779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 890402005780 Right handed beta helix region; Region: Beta_helix; pfam13229 890402005781 Right handed beta helix region; Region: Beta_helix; pfam13229 890402005782 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 890402005783 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 890402005784 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 890402005785 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 890402005786 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 890402005787 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 890402005788 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 890402005789 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 890402005790 MarR family; Region: MarR_2; pfam12802 890402005791 MarR family; Region: MarR_2; cl17246 890402005792 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 890402005793 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 890402005794 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 890402005795 Walker A/P-loop; other site 890402005796 ATP binding site [chemical binding]; other site 890402005797 Q-loop/lid; other site 890402005798 ABC transporter signature motif; other site 890402005799 Walker B; other site 890402005800 D-loop; other site 890402005801 H-loop/switch region; other site 890402005802 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 890402005803 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 890402005804 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 890402005805 Walker A/P-loop; other site 890402005806 ATP binding site [chemical binding]; other site 890402005807 Q-loop/lid; other site 890402005808 ABC transporter signature motif; other site 890402005809 Walker B; other site 890402005810 D-loop; other site 890402005811 H-loop/switch region; other site 890402005812 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402005813 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402005814 DNA binding site [nucleotide binding] 890402005815 domain linker motif; other site 890402005816 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 890402005817 dimerization interface [polypeptide binding]; other site 890402005818 ligand binding site [chemical binding]; other site 890402005819 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 890402005820 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 890402005821 substrate binding site [chemical binding]; other site 890402005822 dimer interface [polypeptide binding]; other site 890402005823 ATP binding site [chemical binding]; other site 890402005824 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 890402005825 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 890402005826 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 890402005827 Walker A/P-loop; other site 890402005828 ATP binding site [chemical binding]; other site 890402005829 Q-loop/lid; other site 890402005830 ABC transporter signature motif; other site 890402005831 Walker B; other site 890402005832 D-loop; other site 890402005833 H-loop/switch region; other site 890402005834 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 890402005835 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 890402005836 Walker A/P-loop; other site 890402005837 ATP binding site [chemical binding]; other site 890402005838 Q-loop/lid; other site 890402005839 ABC transporter signature motif; other site 890402005840 Walker B; other site 890402005841 D-loop; other site 890402005842 H-loop/switch region; other site 890402005843 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 890402005844 active site 890402005845 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 890402005846 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 890402005847 substrate binding site [chemical binding]; other site 890402005848 ATP binding site [chemical binding]; other site 890402005849 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 890402005850 active site 890402005851 tetramer interface [polypeptide binding]; other site 890402005852 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 890402005853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 890402005854 motif II; other site 890402005855 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 890402005856 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 890402005857 dimer interface [polypeptide binding]; other site 890402005858 active site 890402005859 metal binding site [ion binding]; metal-binding site 890402005860 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 890402005861 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 890402005862 substrate binding site [chemical binding]; other site 890402005863 ATP binding site [chemical binding]; other site 890402005864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 890402005865 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 890402005866 Transcriptional regulators [Transcription]; Region: PurR; COG1609 890402005867 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 890402005868 DNA binding site [nucleotide binding] 890402005869 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 890402005870 putative dimerization interface [polypeptide binding]; other site 890402005871 putative ligand binding site [chemical binding]; other site 890402005872 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 890402005873 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 890402005874 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 890402005875 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 890402005876 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 890402005877 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 890402005878 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 890402005879 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 890402005880 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 890402005881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 890402005882 homodimer interface [polypeptide binding]; other site 890402005883 catalytic residue [active] 890402005884 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 890402005885 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 890402005886 HIGH motif; other site 890402005887 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 890402005888 active site 890402005889 KMSKS motif; other site 890402005890 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 890402005891 tRNA binding surface [nucleotide binding]; other site 890402005892 anticodon binding site; other site 890402005893 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 890402005894 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 890402005895 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 890402005896 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 890402005897 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 890402005898 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 890402005899 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 890402005900 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 890402005901 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 890402005902 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719