-- dump date 20140619_002654 -- class Genbank::misc_feature -- table misc_feature_note -- id note 722911000001 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 722911000002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 722911000003 Coenzyme A binding pocket [chemical binding]; other site 722911000004 myosin-cross-reactive antigen; Provisional; Region: PRK13977 722911000005 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 722911000006 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 722911000007 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 722911000008 active site 722911000009 PHP Thumb interface [polypeptide binding]; other site 722911000010 metal binding site [ion binding]; metal-binding site 722911000011 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 722911000012 generic binding surface II; other site 722911000013 generic binding surface I; other site 722911000014 Transposase; Region: DDE_Tnp_ISL3; pfam01610 722911000015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 722911000016 Uncharacterized conserved protein [Function unknown]; Region: COG1479 722911000017 Protein of unknown function DUF262; Region: DUF262; pfam03235 722911000018 Protein of unknown function DUF262; Region: DUF262; pfam03235 722911000019 Uncharacterized conserved protein [Function unknown]; Region: COG1479 722911000020 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 722911000021 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 722911000022 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 722911000023 Family description; Region: UvrD_C_2; pfam13538 722911000024 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 722911000025 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 722911000026 Predicted transcriptional regulator [Transcription]; Region: COG2378 722911000027 putative DNA binding site [nucleotide binding]; other site 722911000028 putative Zn2+ binding site [ion binding]; other site 722911000029 WYL domain; Region: WYL; pfam13280 722911000030 lipoprotein signal peptidase; Provisional; Region: PRK14771 722911000031 DivIVA protein; Region: DivIVA; pfam05103 722911000032 DivIVA domain; Region: DivI1A_domain; TIGR03544 722911000033 Protein of unknown function (DUF552); Region: DUF552; pfam04472 722911000034 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 722911000035 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 722911000036 FMN binding site [chemical binding]; other site 722911000037 active site 722911000038 catalytic residues [active] 722911000039 substrate binding site [chemical binding]; other site 722911000040 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 722911000041 thiamine phosphate binding site [chemical binding]; other site 722911000042 active site 722911000043 pyrophosphate binding site [ion binding]; other site 722911000044 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 722911000045 ThiC-associated domain; Region: ThiC-associated; pfam13667 722911000046 ThiC family; Region: ThiC; pfam01964 722911000047 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 722911000048 substrate binding site [chemical binding]; other site 722911000049 dimer interface [polypeptide binding]; other site 722911000050 ATP binding site [chemical binding]; other site 722911000051 Domain of unknown function DUF77; Region: DUF77; pfam01910 722911000052 benzoate transport; Region: 2A0115; TIGR00895 722911000053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911000054 putative substrate translocation pore; other site 722911000055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911000056 putative substrate translocation pore; other site 722911000057 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 722911000058 serpin-like protein; Provisional; Region: PHA02660 722911000059 reactive center loop; other site 722911000060 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911000061 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911000062 DNA binding site [nucleotide binding] 722911000063 domain linker motif; other site 722911000064 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 722911000065 putative dimerization interface [polypeptide binding]; other site 722911000066 putative ligand binding site [chemical binding]; other site 722911000067 galactoside permease; Reviewed; Region: lacY; PRK09528 722911000068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911000069 putative substrate translocation pore; other site 722911000070 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 722911000071 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 722911000072 substrate binding [chemical binding]; other site 722911000073 active site 722911000074 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 722911000075 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 722911000076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911000077 dimer interface [polypeptide binding]; other site 722911000078 conserved gate region; other site 722911000079 putative PBP binding loops; other site 722911000080 ABC-ATPase subunit interface; other site 722911000081 NMT1/THI5 like; Region: NMT1; pfam09084 722911000082 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 722911000083 active site 722911000084 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 722911000085 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 722911000086 catalytic residue [active] 722911000087 putative FPP diphosphate binding site; other site 722911000088 putative FPP binding hydrophobic cleft; other site 722911000089 dimer interface [polypeptide binding]; other site 722911000090 putative IPP diphosphate binding site; other site 722911000091 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 722911000092 Recombination protein O N terminal; Region: RecO_N; pfam11967 722911000093 Recombination protein O C terminal; Region: RecO_C; pfam02565 722911000094 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 722911000095 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 722911000096 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 722911000097 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 722911000098 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 722911000099 DivIVA domain; Region: DivI1A_domain; TIGR03544 722911000100 DivIVA domain; Region: DivI1A_domain; TIGR03544 722911000101 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 722911000102 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 722911000103 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 722911000104 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 722911000105 substrate binding site [chemical binding]; other site 722911000106 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 722911000107 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 722911000108 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 722911000109 active site 722911000110 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 722911000111 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 722911000112 putative active site [active] 722911000113 redox center [active] 722911000114 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 722911000115 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 722911000116 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 722911000117 glutamate racemase; Provisional; Region: PRK00865 722911000118 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 722911000119 active site 722911000120 nucleophile elbow; other site 722911000121 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 722911000122 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 722911000123 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 722911000124 NIL domain; Region: NIL; pfam09383 722911000125 Zinc-binding dehydrogenase; Region: ADH_zinc_N_2; pfam13602 722911000126 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 722911000127 catalytic residues [active] 722911000128 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 722911000129 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 722911000130 homodimer interface [polypeptide binding]; other site 722911000131 substrate-cofactor binding pocket; other site 722911000132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911000133 catalytic residue [active] 722911000134 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 722911000135 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 722911000136 substrate binding pocket [chemical binding]; other site 722911000137 membrane-bound complex binding site; other site 722911000138 hinge residues; other site 722911000139 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 722911000140 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 722911000141 Walker A/P-loop; other site 722911000142 ATP binding site [chemical binding]; other site 722911000143 Q-loop/lid; other site 722911000144 ABC transporter signature motif; other site 722911000145 Walker B; other site 722911000146 D-loop; other site 722911000147 H-loop/switch region; other site 722911000148 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 722911000149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911000150 dimer interface [polypeptide binding]; other site 722911000151 conserved gate region; other site 722911000152 putative PBP binding loops; other site 722911000153 ABC-ATPase subunit interface; other site 722911000154 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 722911000155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911000156 dimer interface [polypeptide binding]; other site 722911000157 conserved gate region; other site 722911000158 putative PBP binding loops; other site 722911000159 ABC-ATPase subunit interface; other site 722911000160 Predicted esterase [General function prediction only]; Region: COG0400 722911000161 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 722911000162 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 722911000163 elongation factor G; Reviewed; Region: PRK12740 722911000164 G1 box; other site 722911000165 putative GEF interaction site [polypeptide binding]; other site 722911000166 GTP/Mg2+ binding site [chemical binding]; other site 722911000167 Switch I region; other site 722911000168 G2 box; other site 722911000169 G3 box; other site 722911000170 Switch II region; other site 722911000171 G4 box; other site 722911000172 G5 box; other site 722911000173 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 722911000174 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 722911000175 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 722911000176 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 722911000177 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 722911000178 catalytic site [active] 722911000179 G-X2-G-X-G-K; other site 722911000180 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 722911000181 active site 722911000182 dimer interface [polypeptide binding]; other site 722911000183 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 722911000184 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 722911000185 ATP-grasp domain; Region: ATP-grasp_4; cl17255 722911000186 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 722911000187 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 722911000188 ATP-grasp domain; Region: ATP-grasp_4; cl17255 722911000189 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 722911000190 IMP binding site; other site 722911000191 dimer interface [polypeptide binding]; other site 722911000192 interdomain contacts; other site 722911000193 partial ornithine binding site; other site 722911000194 transcription antitermination factor NusB; Region: nusB; TIGR01951 722911000195 putative RNA binding site [nucleotide binding]; other site 722911000196 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 722911000197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911000198 Walker A/P-loop; other site 722911000199 ATP binding site [chemical binding]; other site 722911000200 Q-loop/lid; other site 722911000201 ABC transporter signature motif; other site 722911000202 Walker B; other site 722911000203 D-loop; other site 722911000204 H-loop/switch region; other site 722911000205 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 722911000206 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 722911000207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 722911000208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 722911000209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 722911000210 S-adenosylmethionine binding site [chemical binding]; other site 722911000211 putative alpha-glucosidase; Provisional; Region: PRK10658 722911000212 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 722911000213 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 722911000214 active site 722911000215 catalytic site [active] 722911000216 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 722911000217 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 722911000218 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 722911000219 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 722911000220 putative active site [active] 722911000221 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 722911000222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911000223 dimer interface [polypeptide binding]; other site 722911000224 conserved gate region; other site 722911000225 putative PBP binding loops; other site 722911000226 ABC-ATPase subunit interface; other site 722911000227 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 722911000228 Domain of unknown function DUF59; Region: DUF59; cl00941 722911000229 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 722911000230 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 722911000231 Walker A motif; other site 722911000232 Ligase N family; Region: LIGANc; smart00532 722911000233 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 722911000234 nucleotide binding pocket [chemical binding]; other site 722911000235 K-X-D-G motif; other site 722911000236 catalytic site [active] 722911000237 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 722911000238 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 722911000239 Helix-hairpin-helix motif; Region: HHH; pfam00633 722911000240 helix-hairpin-helix signature motif; other site 722911000241 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 722911000242 Dimer interface [polypeptide binding]; other site 722911000243 TPR repeat; Region: TPR_11; pfam13414 722911000244 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 722911000245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911000246 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 722911000247 Walker A/P-loop; other site 722911000248 ATP binding site [chemical binding]; other site 722911000249 ABC transporter signature motif; other site 722911000250 Walker B; other site 722911000251 D-loop; other site 722911000252 H-loop/switch region; other site 722911000253 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 722911000254 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 722911000255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911000256 homodimer interface [polypeptide binding]; other site 722911000257 catalytic residue [active] 722911000258 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 722911000259 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 722911000260 nucleotide binding site [chemical binding]; other site 722911000261 Nitroreductase family; Region: Nitroreductase; pfam00881 722911000262 FMN binding site [chemical binding]; other site 722911000263 dimer interface [polypeptide binding]; other site 722911000264 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 722911000265 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 722911000266 Probable Catalytic site; other site 722911000267 Predicted membrane protein [Function unknown]; Region: COG3601 722911000268 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 722911000269 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 722911000270 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 722911000271 Walker A/P-loop; other site 722911000272 ATP binding site [chemical binding]; other site 722911000273 Q-loop/lid; other site 722911000274 ABC transporter signature motif; other site 722911000275 Walker B; other site 722911000276 D-loop; other site 722911000277 H-loop/switch region; other site 722911000278 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 722911000279 Walker A/P-loop; other site 722911000280 ATP binding site [chemical binding]; other site 722911000281 Q-loop/lid; other site 722911000282 ABC transporter signature motif; other site 722911000283 Walker B; other site 722911000284 D-loop; other site 722911000285 H-loop/switch region; other site 722911000286 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 722911000287 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 722911000288 Membrane protein of unknown function; Region: DUF360; pfam04020 722911000289 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 722911000290 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 722911000291 NAD binding site [chemical binding]; other site 722911000292 ligand binding site [chemical binding]; other site 722911000293 catalytic site [active] 722911000294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911000295 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 722911000296 putative substrate translocation pore; other site 722911000297 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 722911000298 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 722911000299 TM-ABC transporter signature motif; other site 722911000300 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 722911000301 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 722911000302 Walker A/P-loop; other site 722911000303 ATP binding site [chemical binding]; other site 722911000304 Q-loop/lid; other site 722911000305 ABC transporter signature motif; other site 722911000306 Walker B; other site 722911000307 D-loop; other site 722911000308 H-loop/switch region; other site 722911000309 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 722911000310 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 722911000311 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 722911000312 lipoprotein LpqB; Provisional; Region: PRK13613 722911000313 Sporulation and spore germination; Region: Germane; pfam10646 722911000314 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 722911000315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 722911000316 dimerization interface [polypeptide binding]; other site 722911000317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 722911000318 dimer interface [polypeptide binding]; other site 722911000319 phosphorylation site [posttranslational modification] 722911000320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 722911000321 ATP binding site [chemical binding]; other site 722911000322 Mg2+ binding site [ion binding]; other site 722911000323 G-X-G motif; other site 722911000324 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 722911000325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 722911000326 active site 722911000327 phosphorylation site [posttranslational modification] 722911000328 intermolecular recognition site; other site 722911000329 dimerization interface [polypeptide binding]; other site 722911000330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 722911000331 DNA binding site [nucleotide binding] 722911000332 recombination factor protein RarA; Reviewed; Region: PRK13342 722911000333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911000334 Walker A motif; other site 722911000335 ATP binding site [chemical binding]; other site 722911000336 Walker B motif; other site 722911000337 arginine finger; other site 722911000338 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 722911000339 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 722911000340 ATP binding site [chemical binding]; other site 722911000341 putative Mg++ binding site [ion binding]; other site 722911000342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 722911000343 nucleotide binding region [chemical binding]; other site 722911000344 ATP-binding site [chemical binding]; other site 722911000345 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 722911000346 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 722911000347 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 722911000348 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 722911000349 active site 722911000350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911000351 dimer interface [polypeptide binding]; other site 722911000352 conserved gate region; other site 722911000353 ABC-ATPase subunit interface; other site 722911000354 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 722911000355 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 722911000356 substrate binding pocket [chemical binding]; other site 722911000357 membrane-bound complex binding site; other site 722911000358 hinge residues; other site 722911000359 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 722911000360 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 722911000361 Walker A/P-loop; other site 722911000362 ATP binding site [chemical binding]; other site 722911000363 Q-loop/lid; other site 722911000364 ABC transporter signature motif; other site 722911000365 Walker B; other site 722911000366 D-loop; other site 722911000367 H-loop/switch region; other site 722911000368 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 722911000369 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 722911000370 Creatinine amidohydrolase; Region: Creatininase; pfam02633 722911000371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911000372 metabolite-proton symporter; Region: 2A0106; TIGR00883 722911000373 putative substrate translocation pore; other site 722911000374 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 722911000375 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 722911000376 cytosine deaminase; Provisional; Region: PRK09230 722911000377 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 722911000378 active site 722911000379 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 722911000380 Clp amino terminal domain; Region: Clp_N; pfam02861 722911000381 Clp amino terminal domain; Region: Clp_N; pfam02861 722911000382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911000383 Walker A motif; other site 722911000384 ATP binding site [chemical binding]; other site 722911000385 Walker B motif; other site 722911000386 arginine finger; other site 722911000387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911000388 Walker A motif; other site 722911000389 ATP binding site [chemical binding]; other site 722911000390 Walker B motif; other site 722911000391 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 722911000392 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 722911000393 Ligand Binding Site [chemical binding]; other site 722911000394 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 722911000395 Ligand Binding Site [chemical binding]; other site 722911000396 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 722911000397 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 722911000398 DNA-binding site [nucleotide binding]; DNA binding site 722911000399 RNA-binding motif; other site 722911000400 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 722911000401 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 722911000402 dimerization interface [polypeptide binding]; other site 722911000403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 722911000404 dimer interface [polypeptide binding]; other site 722911000405 phosphorylation site [posttranslational modification] 722911000406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 722911000407 ATP binding site [chemical binding]; other site 722911000408 Mg2+ binding site [ion binding]; other site 722911000409 G-X-G motif; other site 722911000410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 722911000411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 722911000412 active site 722911000413 phosphorylation site [posttranslational modification] 722911000414 intermolecular recognition site; other site 722911000415 dimerization interface [polypeptide binding]; other site 722911000416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 722911000417 DNA binding site [nucleotide binding] 722911000418 Repair protein; Region: Repair_PSII; cl01535 722911000419 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 722911000420 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 722911000421 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 722911000422 ring oligomerisation interface [polypeptide binding]; other site 722911000423 ATP/Mg binding site [chemical binding]; other site 722911000424 stacking interactions; other site 722911000425 hinge regions; other site 722911000426 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 722911000427 DNA-binding site [nucleotide binding]; DNA binding site 722911000428 RNA-binding motif; other site 722911000429 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 722911000430 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 722911000431 ligand binding site [chemical binding]; other site 722911000432 active site 722911000433 UGI interface [polypeptide binding]; other site 722911000434 catalytic site [active] 722911000435 MoxR-like ATPases [General function prediction only]; Region: COG0714 722911000436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 722911000437 von Willebrand factor type A domain; Region: VWA_2; pfam13519 722911000438 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 722911000439 metal ion-dependent adhesion site (MIDAS); other site 722911000440 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 722911000441 adenylosuccinate lyase; Provisional; Region: PRK09285 722911000442 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 722911000443 tetramer interface [polypeptide binding]; other site 722911000444 active site 722911000445 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 722911000446 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 722911000447 IHF dimer interface [polypeptide binding]; other site 722911000448 IHF - DNA interface [nucleotide binding]; other site 722911000449 Pup-ligase protein; Region: Pup_ligase; cl15463 722911000450 ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687 722911000451 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 722911000452 active site 722911000453 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 722911000454 Pup-ligase protein; Region: Pup_ligase; cl15463 722911000455 proteasome ATPase; Region: pup_AAA; TIGR03689 722911000456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911000457 Walker A motif; other site 722911000458 ATP binding site [chemical binding]; other site 722911000459 Walker B motif; other site 722911000460 arginine finger; other site 722911000461 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 722911000462 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 722911000463 phosphoserine phosphatase SerB; Region: serB; TIGR00338 722911000464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911000465 motif II; other site 722911000466 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 722911000467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911000468 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 722911000469 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 722911000470 putative active site [active] 722911000471 substrate binding site [chemical binding]; other site 722911000472 putative cosubstrate binding site; other site 722911000473 catalytic site [active] 722911000474 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 722911000475 substrate binding site [chemical binding]; other site 722911000476 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 722911000477 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 722911000478 S-adenosylmethionine synthetase; Validated; Region: PRK05250 722911000479 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 722911000480 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 722911000481 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 722911000482 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 722911000483 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 722911000484 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 722911000485 active site 722911000486 DNA binding site [nucleotide binding] 722911000487 Int/Topo IB signature motif; other site 722911000488 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 722911000489 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 722911000490 HsdM N-terminal domain; Region: HsdM_N; pfam12161 722911000491 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 722911000492 Methyltransferase domain; Region: Methyltransf_26; pfam13659 722911000493 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 722911000494 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 722911000495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 722911000496 ATP binding site [chemical binding]; other site 722911000497 putative Mg++ binding site [ion binding]; other site 722911000498 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 722911000499 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 722911000500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 722911000501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911000502 homodimer interface [polypeptide binding]; other site 722911000503 catalytic residue [active] 722911000504 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911000505 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911000506 DNA binding site [nucleotide binding] 722911000507 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 722911000508 putative dimerization interface [polypeptide binding]; other site 722911000509 putative ligand binding site [chemical binding]; other site 722911000510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911000511 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 722911000512 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 722911000513 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 722911000514 substrate binding site [chemical binding]; other site 722911000515 ATP binding site [chemical binding]; other site 722911000516 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 722911000517 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 722911000518 dimer interface [polypeptide binding]; other site 722911000519 active site 722911000520 metal binding site [ion binding]; metal-binding site 722911000521 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 722911000522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911000523 motif II; other site 722911000524 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 722911000525 active site 722911000526 tetramer interface [polypeptide binding]; other site 722911000527 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 722911000528 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 722911000529 substrate binding site [chemical binding]; other site 722911000530 ATP binding site [chemical binding]; other site 722911000531 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 722911000532 active site 722911000533 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 722911000534 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 722911000535 Walker A/P-loop; other site 722911000536 ATP binding site [chemical binding]; other site 722911000537 Q-loop/lid; other site 722911000538 ABC transporter signature motif; other site 722911000539 Walker B; other site 722911000540 D-loop; other site 722911000541 H-loop/switch region; other site 722911000542 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 722911000543 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 722911000544 Walker A/P-loop; other site 722911000545 ATP binding site [chemical binding]; other site 722911000546 Q-loop/lid; other site 722911000547 ABC transporter signature motif; other site 722911000548 Walker B; other site 722911000549 D-loop; other site 722911000550 H-loop/switch region; other site 722911000551 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 722911000552 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911000553 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911000554 DNA binding site [nucleotide binding] 722911000555 domain linker motif; other site 722911000556 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911000557 dimerization interface [polypeptide binding]; other site 722911000558 ligand binding site [chemical binding]; other site 722911000559 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 722911000560 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 722911000561 substrate binding site [chemical binding]; other site 722911000562 dimer interface [polypeptide binding]; other site 722911000563 ATP binding site [chemical binding]; other site 722911000564 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 722911000565 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 722911000566 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 722911000567 Walker A/P-loop; other site 722911000568 ATP binding site [chemical binding]; other site 722911000569 Q-loop/lid; other site 722911000570 ABC transporter signature motif; other site 722911000571 Walker B; other site 722911000572 D-loop; other site 722911000573 H-loop/switch region; other site 722911000574 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 722911000575 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 722911000576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911000577 Walker A/P-loop; other site 722911000578 ATP binding site [chemical binding]; other site 722911000579 Q-loop/lid; other site 722911000580 ABC transporter signature motif; other site 722911000581 Walker B; other site 722911000582 D-loop; other site 722911000583 H-loop/switch region; other site 722911000584 MarR family; Region: MarR_2; pfam12802 722911000585 MarR family; Region: MarR_2; cl17246 722911000586 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 722911000587 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 722911000588 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 722911000589 nucleotidyltransferase substrate binding protein, HI0074 family; Region: HI0074; TIGR01987 722911000590 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 722911000591 active site 722911000592 NTP binding site [chemical binding]; other site 722911000593 metal binding triad [ion binding]; metal-binding site 722911000594 antibiotic binding site [chemical binding]; other site 722911000595 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 722911000596 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 722911000597 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 722911000598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 722911000599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 722911000600 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 722911000601 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 722911000602 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 722911000603 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 722911000604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 722911000605 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 722911000606 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 722911000607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 722911000608 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 722911000609 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 722911000610 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 722911000611 ATP cone domain; Region: ATP-cone; pfam03477 722911000612 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 722911000613 Class III ribonucleotide reductase; Region: RNR_III; cd01675 722911000614 active site 722911000615 Zn binding site [ion binding]; other site 722911000616 glycine loop; other site 722911000617 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 722911000618 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 722911000619 generic binding surface II; other site 722911000620 generic binding surface I; other site 722911000621 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 722911000622 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 722911000623 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 722911000624 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 722911000625 acyl-activating enzyme (AAE) consensus motif; other site 722911000626 putative AMP binding site [chemical binding]; other site 722911000627 putative active site [active] 722911000628 putative CoA binding site [chemical binding]; other site 722911000629 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 722911000630 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 722911000631 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 722911000632 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 722911000633 putative catalytic site [active] 722911000634 putative metal binding site [ion binding]; other site 722911000635 putative phosphate binding site [ion binding]; other site 722911000636 exopolyphosphatase; Region: exo_poly_only; TIGR03706 722911000637 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 722911000638 nucleotide binding site [chemical binding]; other site 722911000639 hypothetical protein; Provisional; Region: PRK08960 722911000640 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 722911000641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911000642 homodimer interface [polypeptide binding]; other site 722911000643 catalytic residue [active] 722911000644 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 722911000645 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 722911000646 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 722911000647 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 722911000648 additional DNA contacts [nucleotide binding]; other site 722911000649 mismatch recognition site; other site 722911000650 active site 722911000651 zinc binding site [ion binding]; other site 722911000652 DNA intercalation site [nucleotide binding]; other site 722911000653 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 722911000654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 722911000655 Coenzyme A binding pocket [chemical binding]; other site 722911000656 Penicillinase repressor; Region: Pencillinase_R; cl17580 722911000657 WYL domain; Region: WYL; pfam13280 722911000658 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 722911000659 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 722911000660 putative trimer interface [polypeptide binding]; other site 722911000661 putative CoA binding site [chemical binding]; other site 722911000662 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 722911000663 Citrate synthase; Region: Citrate_synt; pfam00285 722911000664 oxalacetate binding site [chemical binding]; other site 722911000665 citrylCoA binding site [chemical binding]; other site 722911000666 coenzyme A binding site [chemical binding]; other site 722911000667 catalytic triad [active] 722911000668 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 722911000669 active site 722911000670 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 722911000671 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 722911000672 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 722911000673 active site 722911000674 Zn binding site [ion binding]; other site 722911000675 prolyl-tRNA synthetase; Provisional; Region: PRK09194 722911000676 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 722911000677 dimer interface [polypeptide binding]; other site 722911000678 motif 1; other site 722911000679 active site 722911000680 motif 2; other site 722911000681 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 722911000682 putative deacylase active site [active] 722911000683 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 722911000684 active site 722911000685 motif 3; other site 722911000686 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 722911000687 anticodon binding site; other site 722911000688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911000689 PIF1-like helicase; Region: PIF1; pfam05970 722911000690 Walker A motif; other site 722911000691 ATP binding site [chemical binding]; other site 722911000692 Walker B motif; other site 722911000693 arginine finger; other site 722911000694 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 722911000695 catalytic site [active] 722911000696 putative active site [active] 722911000697 putative substrate binding site [chemical binding]; other site 722911000698 dimer interface [polypeptide binding]; other site 722911000699 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 722911000700 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 722911000701 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 722911000702 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 722911000703 active site 722911000704 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 722911000705 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 722911000706 Mg++ binding site [ion binding]; other site 722911000707 putative catalytic motif [active] 722911000708 substrate binding site [chemical binding]; other site 722911000709 maltose O-acetyltransferase; Provisional; Region: PRK10092 722911000710 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 722911000711 active site 722911000712 substrate binding site [chemical binding]; other site 722911000713 trimer interface [polypeptide binding]; other site 722911000714 CoA binding site [chemical binding]; other site 722911000715 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 722911000716 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 722911000717 Walker A/P-loop; other site 722911000718 ATP binding site [chemical binding]; other site 722911000719 Q-loop/lid; other site 722911000720 ABC transporter signature motif; other site 722911000721 Walker B; other site 722911000722 D-loop; other site 722911000723 H-loop/switch region; other site 722911000724 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 722911000725 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 722911000726 Walker A/P-loop; other site 722911000727 ATP binding site [chemical binding]; other site 722911000728 Q-loop/lid; other site 722911000729 ABC transporter signature motif; other site 722911000730 Walker B; other site 722911000731 D-loop; other site 722911000732 H-loop/switch region; other site 722911000733 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 722911000734 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 722911000735 TM-ABC transporter signature motif; other site 722911000736 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 722911000737 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 722911000738 TM-ABC transporter signature motif; other site 722911000739 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 722911000740 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 722911000741 putative ligand binding site [chemical binding]; other site 722911000742 peptide chain release factor 1; Validated; Region: prfA; PRK00591 722911000743 This domain is found in peptide chain release factors; Region: PCRF; smart00937 722911000744 RF-1 domain; Region: RF-1; pfam00472 722911000745 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 722911000746 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 722911000747 non-specific DNA interactions [nucleotide binding]; other site 722911000748 DNA binding site [nucleotide binding] 722911000749 sequence specific DNA binding site [nucleotide binding]; other site 722911000750 putative cAMP binding site [chemical binding]; other site 722911000751 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 722911000752 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 722911000753 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 722911000754 trimer interface [polypeptide binding]; other site 722911000755 active site 722911000756 substrate binding site [chemical binding]; other site 722911000757 CoA binding site [chemical binding]; other site 722911000758 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 722911000759 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 722911000760 inhibitor binding site; inhibition site 722911000761 active site 722911000762 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 722911000763 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 722911000764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911000765 dimer interface [polypeptide binding]; other site 722911000766 conserved gate region; other site 722911000767 putative PBP binding loops; other site 722911000768 ABC-ATPase subunit interface; other site 722911000769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911000770 dimer interface [polypeptide binding]; other site 722911000771 conserved gate region; other site 722911000772 putative PBP binding loops; other site 722911000773 ABC-ATPase subunit interface; other site 722911000774 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 722911000775 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911000776 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911000777 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911000778 DNA binding site [nucleotide binding] 722911000779 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 722911000780 putative dimerization interface [polypeptide binding]; other site 722911000781 putative ligand binding site [chemical binding]; other site 722911000782 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 722911000783 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 722911000784 dimer interface [polypeptide binding]; other site 722911000785 active site 722911000786 metal binding site [ion binding]; metal-binding site 722911000787 xylose isomerase; Provisional; Region: PRK05474 722911000788 xylose isomerase; Region: xylose_isom_A; TIGR02630 722911000789 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 722911000790 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 722911000791 active site 722911000792 catalytic residues [active] 722911000793 metal binding site [ion binding]; metal-binding site 722911000794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911000795 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 722911000796 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 722911000797 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 722911000798 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 722911000799 TM-ABC transporter signature motif; other site 722911000800 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 722911000801 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 722911000802 Walker A/P-loop; other site 722911000803 ATP binding site [chemical binding]; other site 722911000804 Q-loop/lid; other site 722911000805 ABC transporter signature motif; other site 722911000806 Walker B; other site 722911000807 D-loop; other site 722911000808 H-loop/switch region; other site 722911000809 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 722911000810 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 722911000811 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 722911000812 putative ligand binding site [chemical binding]; other site 722911000813 MarR family; Region: MarR_2; pfam12802 722911000814 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 722911000815 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 722911000816 nucleotide binding site [chemical binding]; other site 722911000817 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 722911000818 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 722911000819 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 722911000820 Walker A/P-loop; other site 722911000821 ATP binding site [chemical binding]; other site 722911000822 Q-loop/lid; other site 722911000823 ABC transporter signature motif; other site 722911000824 Walker B; other site 722911000825 D-loop; other site 722911000826 H-loop/switch region; other site 722911000827 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 722911000828 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 722911000829 nucleotide binding site [chemical binding]; other site 722911000830 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 722911000831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911000832 Walker A/P-loop; other site 722911000833 ATP binding site [chemical binding]; other site 722911000834 Q-loop/lid; other site 722911000835 ABC transporter signature motif; other site 722911000836 Walker B; other site 722911000837 D-loop; other site 722911000838 H-loop/switch region; other site 722911000839 ABC transporter; Region: ABC_tran_2; pfam12848 722911000840 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 722911000841 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 722911000842 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 722911000843 active site 722911000844 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 722911000845 catalytic triad [active] 722911000846 dimer interface [polypeptide binding]; other site 722911000847 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 722911000848 homooctamer interface [polypeptide binding]; other site 722911000849 active site 722911000850 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 722911000851 catalytic center binding site [active] 722911000852 ATP binding site [chemical binding]; other site 722911000853 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 722911000854 catalytic center binding site [active] 722911000855 ATP binding site [chemical binding]; other site 722911000856 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 722911000857 dihydropteroate synthase; Region: DHPS; TIGR01496 722911000858 substrate binding pocket [chemical binding]; other site 722911000859 dimer interface [polypeptide binding]; other site 722911000860 inhibitor binding site; inhibition site 722911000861 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 722911000862 GTP cyclohydrolase I; Provisional; Region: PLN03044 722911000863 active site 722911000864 Preprotein translocase subunit; Region: YajC; cl00806 722911000865 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 722911000866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911000867 Walker A motif; other site 722911000868 ATP binding site [chemical binding]; other site 722911000869 Walker B motif; other site 722911000870 arginine finger; other site 722911000871 Peptidase family M41; Region: Peptidase_M41; pfam01434 722911000872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 722911000873 active site 722911000874 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 722911000875 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 722911000876 Ligand Binding Site [chemical binding]; other site 722911000877 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 722911000878 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 722911000879 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 722911000880 Walker A/P-loop; other site 722911000881 ATP binding site [chemical binding]; other site 722911000882 Q-loop/lid; other site 722911000883 ABC transporter signature motif; other site 722911000884 Walker B; other site 722911000885 D-loop; other site 722911000886 H-loop/switch region; other site 722911000887 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 722911000888 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 722911000889 DXD motif; other site 722911000890 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 722911000891 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 722911000892 Domain of unknown function DUF20; Region: UPF0118; pfam01594 722911000893 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 722911000894 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 722911000895 active site 722911000896 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 722911000897 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 722911000898 dimer interface [polypeptide binding]; other site 722911000899 active site 722911000900 metal binding site [ion binding]; metal-binding site 722911000901 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 722911000902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 722911000903 S-adenosylmethionine binding site [chemical binding]; other site 722911000904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911000905 Major Facilitator Superfamily; Region: MFS_1; pfam07690 722911000906 putative substrate translocation pore; other site 722911000907 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 722911000908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 722911000909 NAD(P) binding site [chemical binding]; other site 722911000910 active site 722911000911 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 722911000912 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 722911000913 Helix-turn-helix domain; Region: HTH_36; pfam13730 722911000914 Transcription factor WhiB; Region: Whib; pfam02467 722911000915 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 722911000916 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 722911000917 P-loop; other site 722911000918 Magnesium ion binding site [ion binding]; other site 722911000919 hypothetical protein; Region: PHA01623 722911000920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911000921 Walker A/P-loop; other site 722911000922 ATP binding site [chemical binding]; other site 722911000923 AAA domain; Region: AAA_21; pfam13304 722911000924 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 722911000925 PrgI family protein; Region: PrgI; pfam12666 722911000926 AAA-like domain; Region: AAA_10; pfam12846 722911000927 Domain of unknown function DUF87; Region: DUF87; pfam01935 722911000928 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 722911000929 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 722911000930 Low molecular weight phosphatase family; Region: LMWPc; cd00115 722911000931 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 722911000932 active site 722911000933 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 722911000934 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 722911000935 folate binding site [chemical binding]; other site 722911000936 NADP+ binding site [chemical binding]; other site 722911000937 thymidylate synthase; Reviewed; Region: thyA; PRK01827 722911000938 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 722911000939 dimerization interface [polypeptide binding]; other site 722911000940 active site 722911000941 OsmC-like protein; Region: OsmC; pfam02566 722911000942 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 722911000943 Ligand Binding Site [chemical binding]; other site 722911000944 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 722911000945 Ligand Binding Site [chemical binding]; other site 722911000946 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 722911000947 NlpC/P60 family; Region: NLPC_P60; pfam00877 722911000948 CHAP domain; Region: CHAP; pfam05257 722911000949 phosphoserine aminotransferase; Provisional; Region: PRK03080 722911000950 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 722911000951 catalytic residue [active] 722911000952 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 722911000953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 722911000954 ATP binding site [chemical binding]; other site 722911000955 Mg2+ binding site [ion binding]; other site 722911000956 G-X-G motif; other site 722911000957 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 722911000958 PhoU domain; Region: PhoU; pfam01895 722911000959 PhoU domain; Region: PhoU; pfam01895 722911000960 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 722911000961 catalytic core [active] 722911000962 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 722911000963 UbiA prenyltransferase family; Region: UbiA; pfam01040 722911000964 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 722911000965 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 722911000966 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 722911000967 dimer interface [polypeptide binding]; other site 722911000968 putative anticodon binding site; other site 722911000969 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 722911000970 motif 1; other site 722911000971 dimer interface [polypeptide binding]; other site 722911000972 active site 722911000973 motif 2; other site 722911000974 motif 3; other site 722911000975 MFS transport protein AraJ; Provisional; Region: PRK10091 722911000976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911000977 putative substrate translocation pore; other site 722911000978 Tetratricopeptide repeat; Region: TPR_12; pfam13424 722911000979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 722911000980 binding surface 722911000981 TPR motif; other site 722911000982 Tetratricopeptide repeat; Region: TPR_12; pfam13424 722911000983 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 722911000984 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 722911000985 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 722911000986 PspC domain; Region: PspC; pfam04024 722911000987 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 722911000988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 722911000989 ATP binding site [chemical binding]; other site 722911000990 Mg2+ binding site [ion binding]; other site 722911000991 G-X-G motif; other site 722911000992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 722911000993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 722911000994 active site 722911000995 phosphorylation site [posttranslational modification] 722911000996 intermolecular recognition site; other site 722911000997 dimerization interface [polypeptide binding]; other site 722911000998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 722911000999 DNA binding residues [nucleotide binding] 722911001000 dimerization interface [polypeptide binding]; other site 722911001001 UDP-glucose 4-epimerase; Region: PLN02240 722911001002 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 722911001003 NAD binding site [chemical binding]; other site 722911001004 homodimer interface [polypeptide binding]; other site 722911001005 active site 722911001006 substrate binding site [chemical binding]; other site 722911001007 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 722911001008 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 722911001009 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 722911001010 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 722911001011 Phosphotransferase enzyme family; Region: APH; pfam01636 722911001012 active site 722911001013 substrate binding site [chemical binding]; other site 722911001014 ATP binding site [chemical binding]; other site 722911001015 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 722911001016 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 722911001017 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 722911001018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911001019 dimer interface [polypeptide binding]; other site 722911001020 conserved gate region; other site 722911001021 putative PBP binding loops; other site 722911001022 ABC-ATPase subunit interface; other site 722911001023 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 722911001024 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911001025 seryl-tRNA synthetase; Provisional; Region: PRK05431 722911001026 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 722911001027 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 722911001028 dimer interface [polypeptide binding]; other site 722911001029 active site 722911001030 motif 1; other site 722911001031 motif 2; other site 722911001032 motif 3; other site 722911001033 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 722911001034 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 722911001035 transcriptional antiterminator BglG; Provisional; Region: PRK09772 722911001036 CAT RNA binding domain; Region: CAT_RBD; smart01061 722911001037 PRD domain; Region: PRD; pfam00874 722911001038 PRD domain; Region: PRD; pfam00874 722911001039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911001040 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 722911001041 putative substrate translocation pore; other site 722911001042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911001043 phosphoglucomutase; Validated; Region: PRK07564 722911001044 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 722911001045 active site 722911001046 substrate binding site [chemical binding]; other site 722911001047 metal binding site [ion binding]; metal-binding site 722911001048 Transcriptional regulator; Region: Rrf2; pfam02082 722911001049 Rrf2 family protein; Region: rrf2_super; TIGR00738 722911001050 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 722911001051 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 722911001052 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 722911001053 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 722911001054 RNA/DNA hybrid binding site [nucleotide binding]; other site 722911001055 active site 722911001056 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 722911001057 tetramer (dimer of dimers) interface [polypeptide binding]; other site 722911001058 active site 722911001059 dimer interface [polypeptide binding]; other site 722911001060 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 722911001061 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 722911001062 active site 722911001063 Riboflavin kinase; Region: Flavokinase; pfam01687 722911001064 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 722911001065 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 722911001066 NusA N-terminal domain; Region: NusA_N; pfam08529 722911001067 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 722911001068 RNA binding site [nucleotide binding]; other site 722911001069 homodimer interface [polypeptide binding]; other site 722911001070 NusA-like KH domain; Region: KH_5; pfam13184 722911001071 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 722911001072 G-X-X-G motif; other site 722911001073 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911001074 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911001075 DNA binding site [nucleotide binding] 722911001076 domain linker motif; other site 722911001077 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911001078 dimerization interface [polypeptide binding]; other site 722911001079 ligand binding site [chemical binding]; other site 722911001080 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 722911001081 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 722911001082 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 722911001083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 722911001084 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 722911001085 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 722911001086 dimerization interface 3.5A [polypeptide binding]; other site 722911001087 active site 722911001088 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 722911001089 30S ribosomal protein S11; Validated; Region: PRK05309 722911001090 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 722911001091 30S ribosomal protein S13; Region: bact_S13; TIGR03631 722911001092 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 722911001093 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 722911001094 rRNA binding site [nucleotide binding]; other site 722911001095 predicted 30S ribosome binding site; other site 722911001096 adenylate kinase; Reviewed; Region: adk; PRK00279 722911001097 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 722911001098 AMP-binding site [chemical binding]; other site 722911001099 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 722911001100 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 722911001101 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 722911001102 23S rRNA binding site [nucleotide binding]; other site 722911001103 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 722911001104 23S rRNA interface [nucleotide binding]; other site 722911001105 L21e interface [polypeptide binding]; other site 722911001106 5S rRNA interface [nucleotide binding]; other site 722911001107 L27 interface [polypeptide binding]; other site 722911001108 L5 interface [polypeptide binding]; other site 722911001109 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 722911001110 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 722911001111 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 722911001112 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 722911001113 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 722911001114 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 722911001115 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 722911001116 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 722911001117 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 722911001118 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 722911001119 RNA binding site [nucleotide binding]; other site 722911001120 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 722911001121 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 722911001122 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 722911001123 23S rRNA interface [nucleotide binding]; other site 722911001124 putative translocon interaction site; other site 722911001125 signal recognition particle (SRP54) interaction site; other site 722911001126 L23 interface [polypeptide binding]; other site 722911001127 trigger factor interaction site; other site 722911001128 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 722911001129 23S rRNA interface [nucleotide binding]; other site 722911001130 5S rRNA interface [nucleotide binding]; other site 722911001131 putative antibiotic binding site [chemical binding]; other site 722911001132 L25 interface [polypeptide binding]; other site 722911001133 L27 interface [polypeptide binding]; other site 722911001134 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 722911001135 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 722911001136 G-X-X-G motif; other site 722911001137 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 722911001138 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 722911001139 putative translocon binding site; other site 722911001140 protein-rRNA interface [nucleotide binding]; other site 722911001141 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 722911001142 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 722911001143 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 722911001144 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 722911001145 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 722911001146 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 722911001147 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 722911001148 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 722911001149 YwiC-like protein; Region: YwiC; pfam14256 722911001150 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 722911001151 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 722911001152 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 722911001153 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 722911001154 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 722911001155 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 722911001156 active site 722911001157 catalytic site [active] 722911001158 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 722911001159 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 722911001160 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 722911001161 Uncharacterized conserved protein [Function unknown]; Region: COG1739 722911001162 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 722911001163 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 722911001164 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 722911001165 dimerization interface [polypeptide binding]; other site 722911001166 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 722911001167 NAD binding site [chemical binding]; other site 722911001168 ligand binding site [chemical binding]; other site 722911001169 catalytic site [active] 722911001170 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 722911001171 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 722911001172 putative active site [active] 722911001173 putative metal binding site [ion binding]; other site 722911001174 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 722911001175 DNA polymerase IV; Validated; Region: PRK03858 722911001176 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 722911001177 active site 722911001178 DNA binding site [nucleotide binding] 722911001179 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 722911001180 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 722911001181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911001182 homodimer interface [polypeptide binding]; other site 722911001183 catalytic residue [active] 722911001184 amino acid transporter; Region: 2A0306; TIGR00909 722911001185 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 722911001186 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 722911001187 FAD binding domain; Region: FAD_binding_4; pfam01565 722911001188 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 722911001189 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 722911001190 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 722911001191 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 722911001192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 722911001193 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 722911001194 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 722911001195 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 722911001196 Part of AAA domain; Region: AAA_19; pfam13245 722911001197 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 722911001198 peripheral dimer interface [polypeptide binding]; other site 722911001199 core dimer interface [polypeptide binding]; other site 722911001200 L10 interface [polypeptide binding]; other site 722911001201 L11 interface [polypeptide binding]; other site 722911001202 putative EF-Tu interaction site [polypeptide binding]; other site 722911001203 putative EF-G interaction site [polypeptide binding]; other site 722911001204 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 722911001205 23S rRNA interface [nucleotide binding]; other site 722911001206 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 722911001207 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 722911001208 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 722911001209 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 722911001210 oligomer interface [polypeptide binding]; other site 722911001211 RNA binding site [nucleotide binding]; other site 722911001212 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 722911001213 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 722911001214 RNase E interface [polypeptide binding]; other site 722911001215 trimer interface [polypeptide binding]; other site 722911001216 active site 722911001217 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 722911001218 putative nucleic acid binding region [nucleotide binding]; other site 722911001219 G-X-X-G motif; other site 722911001220 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 722911001221 RNA binding site [nucleotide binding]; other site 722911001222 domain interface; other site 722911001223 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 722911001224 active site 722911001225 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 722911001226 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 722911001227 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911001228 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911001229 DNA binding site [nucleotide binding] 722911001230 domain linker motif; other site 722911001231 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 722911001232 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911001233 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 722911001234 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 722911001235 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 722911001236 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 722911001237 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 722911001238 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 722911001239 ATP-grasp domain; Region: ATP-grasp_4; cl17255 722911001240 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 722911001241 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 722911001242 carboxyltransferase (CT) interaction site; other site 722911001243 biotinylation site [posttranslational modification]; other site 722911001244 BioY family; Region: BioY; pfam02632 722911001245 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 722911001246 Transcriptional regulator [Transcription]; Region: IclR; COG1414 722911001247 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 722911001248 Bacterial transcriptional regulator; Region: IclR; pfam01614 722911001249 Initiator Replication protein; Region: Rep_3; pfam01051 722911001250 MobA/MobL family; Region: MobA_MobL; pfam03389 722911001251 Initiator Replication protein; Region: Rep_3; pfam01051 722911001252 MobA/MobL family; Region: MobA_MobL; pfam03389 722911001253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911001254 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 722911001255 Walker A motif; other site 722911001256 ATP binding site [chemical binding]; other site 722911001257 Walker B motif; other site 722911001258 arginine finger; other site 722911001259 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 722911001260 hypothetical protein; Region: PHA01623 722911001261 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 722911001262 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 722911001263 P-loop; other site 722911001264 Magnesium ion binding site [ion binding]; other site 722911001265 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 722911001266 AAA domain; Region: AAA_30; pfam13604 722911001267 Family description; Region: UvrD_C_2; pfam13538 722911001268 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 722911001269 mRNA/rRNA interface [nucleotide binding]; other site 722911001270 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 722911001271 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 722911001272 23S rRNA interface [nucleotide binding]; other site 722911001273 L7/L12 interface [polypeptide binding]; other site 722911001274 putative thiostrepton binding site; other site 722911001275 L25 interface [polypeptide binding]; other site 722911001276 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 722911001277 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 722911001278 putative homodimer interface [polypeptide binding]; other site 722911001279 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 722911001280 heterodimer interface [polypeptide binding]; other site 722911001281 homodimer interface [polypeptide binding]; other site 722911001282 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 722911001283 aspartate aminotransferase; Provisional; Region: PRK05764 722911001284 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 722911001285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911001286 homodimer interface [polypeptide binding]; other site 722911001287 catalytic residue [active] 722911001288 gamma-glutamyl kinase; Provisional; Region: PRK05429 722911001289 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 722911001290 nucleotide binding site [chemical binding]; other site 722911001291 homotetrameric interface [polypeptide binding]; other site 722911001292 putative phosphate binding site [ion binding]; other site 722911001293 putative allosteric binding site; other site 722911001294 PUA domain; Region: PUA; pfam01472 722911001295 GTPase CgtA; Reviewed; Region: obgE; PRK12296 722911001296 GTP1/OBG; Region: GTP1_OBG; pfam01018 722911001297 Obg GTPase; Region: Obg; cd01898 722911001298 G1 box; other site 722911001299 GTP/Mg2+ binding site [chemical binding]; other site 722911001300 Switch I region; other site 722911001301 G2 box; other site 722911001302 G3 box; other site 722911001303 Switch II region; other site 722911001304 G4 box; other site 722911001305 G5 box; other site 722911001306 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 722911001307 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 722911001308 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 722911001309 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 722911001310 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 722911001311 homodimer interface [polypeptide binding]; other site 722911001312 oligonucleotide binding site [chemical binding]; other site 722911001313 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 722911001314 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 722911001315 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 722911001316 metal binding site [ion binding]; metal-binding site 722911001317 Predicted permeases [General function prediction only]; Region: COG0679 722911001318 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 722911001319 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 722911001320 Walker A/P-loop; other site 722911001321 ATP binding site [chemical binding]; other site 722911001322 Q-loop/lid; other site 722911001323 ABC transporter signature motif; other site 722911001324 Walker B; other site 722911001325 D-loop; other site 722911001326 H-loop/switch region; other site 722911001327 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 722911001328 putative active site [active] 722911001329 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 722911001330 dimer interface [polypeptide binding]; other site 722911001331 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 722911001332 nudix motif; other site 722911001333 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 722911001334 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 722911001335 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 722911001336 active site 722911001337 HIGH motif; other site 722911001338 nucleotide binding site [chemical binding]; other site 722911001339 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 722911001340 KMSK motif region; other site 722911001341 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 722911001342 tRNA binding surface [nucleotide binding]; other site 722911001343 anticodon binding site; other site 722911001344 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 722911001345 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 722911001346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911001347 Major Facilitator Superfamily; Region: MFS_1; pfam07690 722911001348 putative substrate translocation pore; other site 722911001349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 722911001350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 722911001351 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 722911001352 putative dimerization interface [polypeptide binding]; other site 722911001353 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 722911001354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 722911001355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911001356 homodimer interface [polypeptide binding]; other site 722911001357 catalytic residue [active] 722911001358 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 722911001359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 722911001360 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 722911001361 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 722911001362 active site 722911001363 FMN binding site [chemical binding]; other site 722911001364 substrate binding site [chemical binding]; other site 722911001365 CAAX protease self-immunity; Region: Abi; pfam02517 722911001366 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 722911001367 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 722911001368 substrate binding site [chemical binding]; other site 722911001369 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 722911001370 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 722911001371 substrate binding site [chemical binding]; other site 722911001372 ligand binding site [chemical binding]; other site 722911001373 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 722911001374 Transcriptional regulator [Transcription]; Region: IclR; COG1414 722911001375 Bacterial transcriptional regulator; Region: IclR; pfam01614 722911001376 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 722911001377 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 722911001378 putative active site [active] 722911001379 putative metal binding site [ion binding]; other site 722911001380 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 722911001381 polyphosphate kinase; Provisional; Region: PRK05443 722911001382 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 722911001383 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 722911001384 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 722911001385 putative domain interface [polypeptide binding]; other site 722911001386 putative active site [active] 722911001387 catalytic site [active] 722911001388 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 722911001389 putative domain interface [polypeptide binding]; other site 722911001390 putative active site [active] 722911001391 catalytic site [active] 722911001392 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 722911001393 active site 722911001394 Ap6A binding site [chemical binding]; other site 722911001395 nudix motif; other site 722911001396 metal binding site [ion binding]; metal-binding site 722911001397 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 722911001398 catalytic core [active] 722911001399 AAA domain; Region: AAA_14; pfam13173 722911001400 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 722911001401 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 722911001402 active site 722911001403 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 722911001404 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 722911001405 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 722911001406 active site 722911001407 catalytic site [active] 722911001408 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 722911001409 active site 722911001410 HIGH motif; other site 722911001411 nucleotide binding site [chemical binding]; other site 722911001412 active site 722911001413 KMSKS motif; other site 722911001414 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 722911001415 Clp amino terminal domain; Region: Clp_N; pfam02861 722911001416 Clp amino terminal domain; Region: Clp_N; pfam02861 722911001417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911001418 Walker A motif; other site 722911001419 ATP binding site [chemical binding]; other site 722911001420 Walker B motif; other site 722911001421 arginine finger; other site 722911001422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911001423 Walker A motif; other site 722911001424 ATP binding site [chemical binding]; other site 722911001425 Walker B motif; other site 722911001426 arginine finger; other site 722911001427 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 722911001428 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 722911001429 active sites [active] 722911001430 tetramer interface [polypeptide binding]; other site 722911001431 Transcriptional regulator [Transcription]; Region: IclR; COG1414 722911001432 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 722911001433 Bacterial transcriptional regulator; Region: IclR; pfam01614 722911001434 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 722911001435 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 722911001436 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 722911001437 UDP-galactopyranose mutase; Region: GLF; pfam03275 722911001438 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 722911001439 putative transposase OrfB; Reviewed; Region: PHA02517 722911001440 HTH-like domain; Region: HTH_21; pfam13276 722911001441 Integrase core domain; Region: rve; pfam00665 722911001442 Integrase core domain; Region: rve_2; pfam13333 722911001443 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 722911001444 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 722911001445 Walker A/P-loop; other site 722911001446 ATP binding site [chemical binding]; other site 722911001447 Q-loop/lid; other site 722911001448 ABC transporter signature motif; other site 722911001449 Walker B; other site 722911001450 D-loop; other site 722911001451 H-loop/switch region; other site 722911001452 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 722911001453 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 722911001454 Rhamnan synthesis protein F; Region: RgpF; pfam05045 722911001455 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 722911001456 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 722911001457 substrate binding site; other site 722911001458 tetramer interface; other site 722911001459 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 722911001460 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 722911001461 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 722911001462 NADP binding site [chemical binding]; other site 722911001463 active site 722911001464 putative substrate binding site [chemical binding]; other site 722911001465 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 722911001466 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 722911001467 NAD binding site [chemical binding]; other site 722911001468 substrate binding site [chemical binding]; other site 722911001469 homodimer interface [polypeptide binding]; other site 722911001470 active site 722911001471 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 722911001472 Ligand binding site; other site 722911001473 Putative Catalytic site; other site 722911001474 DXD motif; other site 722911001475 Transposase; Region: DDE_Tnp_ISL3; pfam01610 722911001476 Transposase; Region: DDE_Tnp_ISL3; pfam01610 722911001477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 722911001478 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 722911001479 Acyltransferase family; Region: Acyl_transf_3; pfam01757 722911001480 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 722911001481 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 722911001482 FtsX-like permease family; Region: FtsX; pfam02687 722911001483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911001484 ABC transporter; Region: ABC_tran; pfam00005 722911001485 Q-loop/lid; other site 722911001486 ABC transporter signature motif; other site 722911001487 Walker B; other site 722911001488 D-loop; other site 722911001489 H-loop/switch region; other site 722911001490 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 722911001491 Zn2+ binding site [ion binding]; other site 722911001492 Mg2+ binding site [ion binding]; other site 722911001493 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 722911001494 putative active site [active] 722911001495 putative dimer interface [polypeptide binding]; other site 722911001496 K+ potassium transporter; Region: K_trans; pfam02705 722911001497 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 722911001498 active site 722911001499 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 722911001500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911001501 dimer interface [polypeptide binding]; other site 722911001502 conserved gate region; other site 722911001503 putative PBP binding loops; other site 722911001504 ABC-ATPase subunit interface; other site 722911001505 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 722911001506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911001507 dimer interface [polypeptide binding]; other site 722911001508 conserved gate region; other site 722911001509 putative PBP binding loops; other site 722911001510 ABC-ATPase subunit interface; other site 722911001511 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 722911001512 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911001513 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 722911001514 active site 722911001515 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 722911001516 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 722911001517 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911001518 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911001519 DNA binding site [nucleotide binding] 722911001520 domain linker motif; other site 722911001521 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911001522 dimerization interface [polypeptide binding]; other site 722911001523 ligand binding site [chemical binding]; other site 722911001524 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 722911001525 substrate binding site [chemical binding]; other site 722911001526 active site 722911001527 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 722911001528 active site 722911001529 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 722911001530 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 722911001531 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 722911001532 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 722911001533 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 722911001534 Walker A/P-loop; other site 722911001535 ATP binding site [chemical binding]; other site 722911001536 Q-loop/lid; other site 722911001537 ABC transporter signature motif; other site 722911001538 Walker B; other site 722911001539 D-loop; other site 722911001540 H-loop/switch region; other site 722911001541 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 722911001542 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 722911001543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911001544 Walker A/P-loop; other site 722911001545 ATP binding site [chemical binding]; other site 722911001546 Q-loop/lid; other site 722911001547 ABC transporter signature motif; other site 722911001548 Walker B; other site 722911001549 D-loop; other site 722911001550 H-loop/switch region; other site 722911001551 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911001552 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911001553 DNA binding site [nucleotide binding] 722911001554 domain linker motif; other site 722911001555 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911001556 dimerization interface [polypeptide binding]; other site 722911001557 ligand binding site [chemical binding]; other site 722911001558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 722911001559 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 722911001560 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 722911001561 trimer interface [polypeptide binding]; other site 722911001562 active site 722911001563 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 722911001564 Predicted methyltransferases [General function prediction only]; Region: COG0313 722911001565 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 722911001566 putative SAM binding site [chemical binding]; other site 722911001567 putative homodimer interface [polypeptide binding]; other site 722911001568 ApbE family; Region: ApbE; pfam02424 722911001569 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 722911001570 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 722911001571 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 722911001572 Walker A/P-loop; other site 722911001573 ATP binding site [chemical binding]; other site 722911001574 Q-loop/lid; other site 722911001575 ABC transporter signature motif; other site 722911001576 Walker B; other site 722911001577 D-loop; other site 722911001578 H-loop/switch region; other site 722911001579 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 722911001580 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 722911001581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911001582 Walker A/P-loop; other site 722911001583 ATP binding site [chemical binding]; other site 722911001584 Q-loop/lid; other site 722911001585 ABC transporter signature motif; other site 722911001586 Walker B; other site 722911001587 D-loop; other site 722911001588 H-loop/switch region; other site 722911001589 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 722911001590 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 722911001591 Divergent AAA domain; Region: AAA_4; pfam04326 722911001592 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 722911001593 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 722911001594 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 722911001595 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 722911001596 Walker A/P-loop; other site 722911001597 ATP binding site [chemical binding]; other site 722911001598 Q-loop/lid; other site 722911001599 ABC transporter signature motif; other site 722911001600 Walker B; other site 722911001601 D-loop; other site 722911001602 H-loop/switch region; other site 722911001603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 722911001604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 722911001605 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 722911001606 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 722911001607 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 722911001608 AAA domain; Region: AAA_14; pfam13173 722911001609 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 722911001610 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 722911001611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 722911001612 Transposase; Region: DDE_Tnp_ISL3; pfam01610 722911001613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 722911001614 Transposase; Region: DDE_Tnp_ISL3; pfam01610 722911001615 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 722911001616 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 722911001617 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 722911001618 active site 722911001619 Protein of unknown function, DUF624; Region: DUF624; pfam04854 722911001620 Protein of unknown function, DUF624; Region: DUF624; cl02369 722911001621 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 722911001622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911001623 dimer interface [polypeptide binding]; other site 722911001624 conserved gate region; other site 722911001625 putative PBP binding loops; other site 722911001626 ABC-ATPase subunit interface; other site 722911001627 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 722911001628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911001629 putative PBP binding loops; other site 722911001630 dimer interface [polypeptide binding]; other site 722911001631 ABC-ATPase subunit interface; other site 722911001632 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911001633 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911001634 DNA binding site [nucleotide binding] 722911001635 domain linker motif; other site 722911001636 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911001637 ligand binding site [chemical binding]; other site 722911001638 dimerization interface [polypeptide binding]; other site 722911001639 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 722911001640 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 722911001641 catalytic core [active] 722911001642 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 722911001643 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 722911001644 dimer interface [polypeptide binding]; other site 722911001645 FMN binding site [chemical binding]; other site 722911001646 NADPH bind site [chemical binding]; other site 722911001647 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 722911001648 Predicted membrane protein [Function unknown]; Region: COG1511 722911001649 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 722911001650 Predicted membrane protein [Function unknown]; Region: COG1511 722911001651 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 722911001652 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 722911001653 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 722911001654 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 722911001655 active site 722911001656 catalytic tetrad [active] 722911001657 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 722911001658 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 722911001659 nucleotide binding site [chemical binding]; other site 722911001660 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 722911001661 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 722911001662 NAD binding site [chemical binding]; other site 722911001663 dimerization interface [polypeptide binding]; other site 722911001664 product binding site; other site 722911001665 substrate binding site [chemical binding]; other site 722911001666 zinc binding site [ion binding]; other site 722911001667 catalytic residues [active] 722911001668 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 722911001669 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 722911001670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911001671 homodimer interface [polypeptide binding]; other site 722911001672 catalytic residue [active] 722911001673 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 722911001674 putative active site pocket [active] 722911001675 4-fold oligomerization interface [polypeptide binding]; other site 722911001676 metal binding residues [ion binding]; metal-binding site 722911001677 3-fold/trimer interface [polypeptide binding]; other site 722911001678 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 722911001679 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 722911001680 putative active site [active] 722911001681 oxyanion strand; other site 722911001682 catalytic triad [active] 722911001683 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 722911001684 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 722911001685 catalytic residues [active] 722911001686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 722911001687 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 722911001688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 722911001689 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 722911001690 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 722911001691 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 722911001692 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 722911001693 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 722911001694 ATP binding site [chemical binding]; other site 722911001695 putative Mg++ binding site [ion binding]; other site 722911001696 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 722911001697 nucleotide binding region [chemical binding]; other site 722911001698 ATP-binding site [chemical binding]; other site 722911001699 Helicase associated domain (HA2); Region: HA2; pfam04408 722911001700 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 722911001701 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 722911001702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 722911001703 S-adenosylmethionine binding site [chemical binding]; other site 722911001704 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 722911001705 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 722911001706 NAD binding site [chemical binding]; other site 722911001707 dimer interface [polypeptide binding]; other site 722911001708 substrate binding site [chemical binding]; other site 722911001709 tetramer (dimer of dimers) interface [polypeptide binding]; other site 722911001710 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 722911001711 ATP cone domain; Region: ATP-cone; pfam03477 722911001712 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 722911001713 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 722911001714 ligand binding site [chemical binding]; other site 722911001715 NAD binding site [chemical binding]; other site 722911001716 tetramer interface [polypeptide binding]; other site 722911001717 catalytic site [active] 722911001718 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 722911001719 L-serine binding site [chemical binding]; other site 722911001720 ACT domain interface; other site 722911001721 Part of AAA domain; Region: AAA_19; pfam13245 722911001722 Family description; Region: UvrD_C_2; pfam13538 722911001723 cell division protein MraZ; Reviewed; Region: PRK00326 722911001724 MraZ protein; Region: MraZ; pfam02381 722911001725 MraZ protein; Region: MraZ; pfam02381 722911001726 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 722911001727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 722911001728 S-adenosylmethionine binding site [chemical binding]; other site 722911001729 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 722911001730 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 722911001731 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 722911001732 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 722911001733 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 722911001734 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 722911001735 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 722911001736 NAD binding site [chemical binding]; other site 722911001737 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 722911001738 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 722911001739 cell division protein FtsW; Region: ftsW; TIGR02614 722911001740 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 722911001741 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 722911001742 active site 722911001743 homodimer interface [polypeptide binding]; other site 722911001744 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 722911001745 putative ADP-ribose binding site [chemical binding]; other site 722911001746 putative active site [active] 722911001747 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 722911001748 metal ion-dependent adhesion site (MIDAS); other site 722911001749 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 722911001750 putative active site [active] 722911001751 dimerization interface [polypeptide binding]; other site 722911001752 putative tRNAtyr binding site [nucleotide binding]; other site 722911001753 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 722911001754 active site 722911001755 catalytic site [active] 722911001756 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 722911001757 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 722911001758 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 722911001759 active site 722911001760 catalytic site [active] 722911001761 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 722911001762 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 722911001763 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 722911001764 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911001765 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 722911001766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911001767 dimer interface [polypeptide binding]; other site 722911001768 conserved gate region; other site 722911001769 putative PBP binding loops; other site 722911001770 ABC-ATPase subunit interface; other site 722911001771 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 722911001772 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 722911001773 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 722911001774 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 722911001775 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 722911001776 active site 722911001777 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 722911001778 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 722911001779 putative active cleft [active] 722911001780 Uncharacterized conserved protein [Function unknown]; Region: COG3538 722911001781 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 722911001782 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 722911001783 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 722911001784 putative substrate binding site [chemical binding]; other site 722911001785 putative ATP binding site [chemical binding]; other site 722911001786 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 722911001787 putative DNA binding site [nucleotide binding]; other site 722911001788 Transcriptional regulators [Transcription]; Region: MarR; COG1846 722911001789 putative Zn2+ binding site [ion binding]; other site 722911001790 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 722911001791 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 722911001792 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 722911001793 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 722911001794 nucleotide binding site [chemical binding]; other site 722911001795 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 722911001796 non-specific DNA interactions [nucleotide binding]; other site 722911001797 DNA binding site [nucleotide binding] 722911001798 sequence specific DNA binding site [nucleotide binding]; other site 722911001799 putative cAMP binding site [chemical binding]; other site 722911001800 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 722911001801 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 722911001802 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 722911001803 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 722911001804 active site 722911001805 trimer interface [polypeptide binding]; other site 722911001806 allosteric site; other site 722911001807 active site lid [active] 722911001808 hexamer (dimer of trimers) interface [polypeptide binding]; other site 722911001809 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 722911001810 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 722911001811 active site 722911001812 dimer interface [polypeptide binding]; other site 722911001813 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 722911001814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911001815 dimer interface [polypeptide binding]; other site 722911001816 conserved gate region; other site 722911001817 ABC-ATPase subunit interface; other site 722911001818 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 722911001819 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 722911001820 Walker A/P-loop; other site 722911001821 ATP binding site [chemical binding]; other site 722911001822 Q-loop/lid; other site 722911001823 ABC transporter signature motif; other site 722911001824 Walker B; other site 722911001825 D-loop; other site 722911001826 H-loop/switch region; other site 722911001827 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 722911001828 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 722911001829 Walker A/P-loop; other site 722911001830 ATP binding site [chemical binding]; other site 722911001831 Q-loop/lid; other site 722911001832 ABC transporter signature motif; other site 722911001833 Walker B; other site 722911001834 D-loop; other site 722911001835 H-loop/switch region; other site 722911001836 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 722911001837 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 722911001838 proline aminopeptidase P II; Provisional; Region: PRK10879 722911001839 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 722911001840 active site 722911001841 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 722911001842 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 722911001843 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 722911001844 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 722911001845 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 722911001846 Walker A/P-loop; other site 722911001847 ATP binding site [chemical binding]; other site 722911001848 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 722911001849 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 722911001850 ABC transporter signature motif; other site 722911001851 Walker B; other site 722911001852 D-loop; other site 722911001853 H-loop/switch region; other site 722911001854 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 722911001855 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 722911001856 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 722911001857 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 722911001858 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 722911001859 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 722911001860 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 722911001861 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 722911001862 DNA binding residues [nucleotide binding] 722911001863 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 722911001864 active site 722911001865 catalytic residues [active] 722911001866 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 722911001867 active site 722911001868 catalytic residues [active] 722911001869 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 722911001870 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 722911001871 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 722911001872 putative deacylase active site [active] 722911001873 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 722911001874 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 722911001875 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 722911001876 Thiamine pyrophosphokinase; Region: TPK; cd07995 722911001877 active site 722911001878 dimerization interface [polypeptide binding]; other site 722911001879 thiamine binding site [chemical binding]; other site 722911001880 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 722911001881 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 722911001882 23S rRNA binding site [nucleotide binding]; other site 722911001883 L21 binding site [polypeptide binding]; other site 722911001884 L13 binding site [polypeptide binding]; other site 722911001885 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 722911001886 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 722911001887 active site 722911001888 Int/Topo IB signature motif; other site 722911001889 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 722911001890 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 722911001891 Walker A/P-loop; other site 722911001892 ATP binding site [chemical binding]; other site 722911001893 Q-loop/lid; other site 722911001894 ABC transporter signature motif; other site 722911001895 Walker B; other site 722911001896 D-loop; other site 722911001897 H-loop/switch region; other site 722911001898 FtsX-like permease family; Region: FtsX; pfam02687 722911001899 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 722911001900 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 722911001901 P-loop; other site 722911001902 Magnesium ion binding site [ion binding]; other site 722911001903 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 722911001904 Magnesium ion binding site [ion binding]; other site 722911001905 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 722911001906 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 722911001907 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 722911001908 nudix motif; other site 722911001909 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 722911001910 quinolinate synthetase; Provisional; Region: PRK09375 722911001911 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 722911001912 L-aspartate oxidase; Provisional; Region: PRK06175 722911001913 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 722911001914 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 722911001915 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 722911001916 dimerization interface [polypeptide binding]; other site 722911001917 active site 722911001918 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 722911001919 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 722911001920 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 722911001921 catalytic residue [active] 722911001922 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 722911001923 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 722911001924 G1 box; other site 722911001925 putative GEF interaction site [polypeptide binding]; other site 722911001926 GTP/Mg2+ binding site [chemical binding]; other site 722911001927 Switch I region; other site 722911001928 G2 box; other site 722911001929 G3 box; other site 722911001930 Switch II region; other site 722911001931 G4 box; other site 722911001932 G5 box; other site 722911001933 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 722911001934 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 722911001935 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 722911001936 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 722911001937 Prephenate dehydratase; Region: PDT; pfam00800 722911001938 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 722911001939 putative L-Phe binding site [chemical binding]; other site 722911001940 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 722911001941 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 722911001942 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 722911001943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911001944 dimer interface [polypeptide binding]; other site 722911001945 conserved gate region; other site 722911001946 putative PBP binding loops; other site 722911001947 ABC-ATPase subunit interface; other site 722911001948 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 722911001949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911001950 dimer interface [polypeptide binding]; other site 722911001951 conserved gate region; other site 722911001952 putative PBP binding loops; other site 722911001953 ABC-ATPase subunit interface; other site 722911001954 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 722911001955 AAA domain; Region: AAA_21; pfam13304 722911001956 Walker A/P-loop; other site 722911001957 ATP binding site [chemical binding]; other site 722911001958 Q-loop/lid; other site 722911001959 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 722911001960 ABC transporter signature motif; other site 722911001961 Walker B; other site 722911001962 D-loop; other site 722911001963 H-loop/switch region; other site 722911001964 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 722911001965 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 722911001966 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 722911001967 Walker A/P-loop; other site 722911001968 ATP binding site [chemical binding]; other site 722911001969 Q-loop/lid; other site 722911001970 ABC transporter signature motif; other site 722911001971 Walker B; other site 722911001972 D-loop; other site 722911001973 H-loop/switch region; other site 722911001974 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 722911001975 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 722911001976 putative active site [active] 722911001977 putative catalytic site [active] 722911001978 putative DNA binding site [nucleotide binding]; other site 722911001979 putative phosphate binding site [ion binding]; other site 722911001980 metal binding site A [ion binding]; metal-binding site 722911001981 putative AP binding site [nucleotide binding]; other site 722911001982 putative metal binding site B [ion binding]; other site 722911001983 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 722911001984 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 722911001985 TRAM domain; Region: TRAM; cl01282 722911001986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 722911001987 S-adenosylmethionine binding site [chemical binding]; other site 722911001988 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 722911001989 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 722911001990 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 722911001991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911001992 motif II; other site 722911001993 aconitate hydratase; Validated; Region: PRK09277 722911001994 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 722911001995 substrate binding site [chemical binding]; other site 722911001996 ligand binding site [chemical binding]; other site 722911001997 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 722911001998 substrate binding site [chemical binding]; other site 722911001999 RelB antitoxin; Region: RelB; cl01171 722911002000 Protein of unknown function DUF262; Region: DUF262; pfam03235 722911002001 Uncharacterized conserved protein [Function unknown]; Region: COG1479 722911002002 Protein of unknown function DUF262; Region: DUF262; pfam03235 722911002003 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 722911002004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 722911002005 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 722911002006 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 722911002007 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 722911002008 EamA-like transporter family; Region: EamA; pfam00892 722911002009 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 722911002010 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 722911002011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 722911002012 FeS/SAM binding site; other site 722911002013 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 722911002014 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 722911002015 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 722911002016 Fic/DOC family; Region: Fic; cl00960 722911002017 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 722911002018 Competence-damaged protein; Region: CinA; pfam02464 722911002019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 722911002020 sequence-specific DNA binding site [nucleotide binding]; other site 722911002021 salt bridge; other site 722911002022 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 722911002023 recombinase A; Provisional; Region: recA; PRK09354 722911002024 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 722911002025 hexamer interface [polypeptide binding]; other site 722911002026 Walker A motif; other site 722911002027 ATP binding site [chemical binding]; other site 722911002028 Walker B motif; other site 722911002029 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 722911002030 30S subunit binding site; other site 722911002031 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 722911002032 DEAD/DEAH box helicase; Region: DEAD; pfam00270 722911002033 ATP binding site [chemical binding]; other site 722911002034 putative Mg++ binding site [ion binding]; other site 722911002035 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 722911002036 SEC-C motif; Region: SEC-C; pfam02810 722911002037 Transposase; Region: DDE_Tnp_ISL3; pfam01610 722911002038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 722911002039 Transposase; Region: DDE_Tnp_ISL3; pfam01610 722911002040 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 722911002041 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 722911002042 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 722911002043 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 722911002044 Catalytic domain of Protein Kinases; Region: PKc; cd00180 722911002045 active site 722911002046 ATP binding site [chemical binding]; other site 722911002047 substrate binding site [chemical binding]; other site 722911002048 activation loop (A-loop); other site 722911002049 PASTA domain; Region: PASTA; pfam03793 722911002050 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 722911002051 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 722911002052 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 722911002053 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 722911002054 substrate binding pocket [chemical binding]; other site 722911002055 chain length determination region; other site 722911002056 substrate-Mg2+ binding site; other site 722911002057 catalytic residues [active] 722911002058 aspartate-rich region 1; other site 722911002059 active site lid residues [active] 722911002060 aspartate-rich region 2; other site 722911002061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 722911002062 Mg2+ binding site [ion binding]; other site 722911002063 G-X-G motif; other site 722911002064 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 722911002065 anchoring element; other site 722911002066 dimer interface [polypeptide binding]; other site 722911002067 ATP binding site [chemical binding]; other site 722911002068 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 722911002069 active site 722911002070 metal binding site [ion binding]; metal-binding site 722911002071 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 722911002072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911002073 Major Facilitator Superfamily; Region: MFS_1; pfam07690 722911002074 putative substrate translocation pore; other site 722911002075 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 722911002076 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 722911002077 substrate binding site [chemical binding]; other site 722911002078 dimer interface [polypeptide binding]; other site 722911002079 ATP binding site [chemical binding]; other site 722911002080 DEAD-like helicases superfamily; Region: DEXDc; smart00487 722911002081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 722911002082 ATP binding site [chemical binding]; other site 722911002083 putative Mg++ binding site [ion binding]; other site 722911002084 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 722911002085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 722911002086 nucleotide binding region [chemical binding]; other site 722911002087 ATP-binding site [chemical binding]; other site 722911002088 DEAD/H associated; Region: DEAD_assoc; pfam08494 722911002089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 722911002090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 722911002091 phosphorylation site [posttranslational modification] 722911002092 intermolecular recognition site; other site 722911002093 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 722911002094 DNA binding site [nucleotide binding] 722911002095 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 722911002096 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 722911002097 CAP-like domain; other site 722911002098 active site 722911002099 primary dimer interface [polypeptide binding]; other site 722911002100 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 722911002101 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 722911002102 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 722911002103 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 722911002104 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 722911002105 trimer interface [polypeptide binding]; other site 722911002106 active site 722911002107 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 722911002108 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 722911002109 Zn2+ binding site [ion binding]; other site 722911002110 Mg2+ binding site [ion binding]; other site 722911002111 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 722911002112 synthetase active site [active] 722911002113 NTP binding site [chemical binding]; other site 722911002114 metal binding site [ion binding]; metal-binding site 722911002115 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 722911002116 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 722911002117 Integrase core domain; Region: rve; pfam00665 722911002118 Integrase core domain; Region: rve_2; pfam13333 722911002119 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 722911002120 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 722911002121 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 722911002122 Int/Topo IB signature motif; other site 722911002123 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 722911002124 Int/Topo IB signature motif; other site 722911002125 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 722911002126 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 722911002127 active site 722911002128 DNA binding site [nucleotide binding] 722911002129 Int/Topo IB signature motif; other site 722911002130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 722911002131 Helix-turn-helix domain; Region: HTH_28; pfam13518 722911002132 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 722911002133 active site 722911002134 EamA-like transporter family; Region: EamA; pfam00892 722911002135 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 722911002136 EamA-like transporter family; Region: EamA; pfam00892 722911002137 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 722911002138 Methyltransferase domain; Region: Methyltransf_26; pfam13659 722911002139 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 722911002140 catalytic core [active] 722911002141 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 722911002142 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 722911002143 Cl binding site [ion binding]; other site 722911002144 oligomer interface [polypeptide binding]; other site 722911002145 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 722911002146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 722911002147 substrate binding pocket [chemical binding]; other site 722911002148 membrane-bound complex binding site; other site 722911002149 hinge residues; other site 722911002150 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495 722911002151 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 722911002152 active site 722911002153 HIGH motif; other site 722911002154 nucleotide binding site [chemical binding]; other site 722911002155 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 722911002156 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 722911002157 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 722911002158 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 722911002159 active site 722911002160 KMSKS motif; other site 722911002161 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 722911002162 tRNA binding surface [nucleotide binding]; other site 722911002163 Helix-hairpin-helix motif; Region: HHH; pfam00633 722911002164 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 722911002165 Competence protein; Region: Competence; pfam03772 722911002166 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 722911002167 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 722911002168 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 722911002169 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 722911002170 Glycoprotease family; Region: Peptidase_M22; pfam00814 722911002171 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 722911002172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 722911002173 Coenzyme A binding pocket [chemical binding]; other site 722911002174 UGMP family protein; Validated; Region: PRK09604 722911002175 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 722911002176 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 722911002177 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 722911002178 active site 722911002179 DNA binding site [nucleotide binding] 722911002180 Int/Topo IB signature motif; other site 722911002181 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 722911002182 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 722911002183 Fic family protein [Function unknown]; Region: COG3177 722911002184 Fic/DOC family; Region: Fic; pfam02661 722911002185 Antirestriction protein (ArdA); Region: ArdA; cl01953 722911002186 CHAP domain; Region: CHAP; pfam05257 722911002187 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 722911002188 N-acetyl-D-glucosamine binding site [chemical binding]; other site 722911002189 catalytic residue [active] 722911002190 DNA topoisomerase III; Provisional; Region: PRK07726 722911002191 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 722911002192 active site 722911002193 putative interdomain interaction site [polypeptide binding]; other site 722911002194 putative metal-binding site [ion binding]; other site 722911002195 putative nucleotide binding site [chemical binding]; other site 722911002196 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 722911002197 domain I; other site 722911002198 DNA binding groove [nucleotide binding] 722911002199 phosphate binding site [ion binding]; other site 722911002200 domain II; other site 722911002201 domain III; other site 722911002202 nucleotide binding site [chemical binding]; other site 722911002203 catalytic site [active] 722911002204 domain IV; other site 722911002205 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 722911002206 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 722911002207 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 722911002208 Putative zinc-finger; Region: zf-HC2; pfam13490 722911002209 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 722911002210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 722911002211 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 722911002212 DNA binding residues [nucleotide binding] 722911002213 Fic family protein [Function unknown]; Region: COG3177 722911002214 Fic/DOC family; Region: Fic; cl00960 722911002215 AAA-like domain; Region: AAA_10; pfam12846 722911002216 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 722911002217 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 722911002218 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 722911002219 P-loop; other site 722911002220 Magnesium ion binding site [ion binding]; other site 722911002221 Transcription factor WhiB; Region: Whib; pfam02467 722911002222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 722911002223 non-specific DNA binding site [nucleotide binding]; other site 722911002224 salt bridge; other site 722911002225 sequence-specific DNA binding site [nucleotide binding]; other site 722911002226 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 722911002227 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 722911002228 isocitrate dehydrogenase; Validated; Region: PRK08299 722911002229 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 722911002230 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 722911002231 acyl-activating enzyme (AAE) consensus motif; other site 722911002232 putative AMP binding site [chemical binding]; other site 722911002233 putative active site [active] 722911002234 putative CoA binding site [chemical binding]; other site 722911002235 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 722911002236 rRNA interaction site [nucleotide binding]; other site 722911002237 S8 interaction site; other site 722911002238 putative laminin-1 binding site; other site 722911002239 elongation factor Ts; Provisional; Region: tsf; PRK09377 722911002240 Elongation factor TS; Region: EF_TS; pfam00889 722911002241 Elongation factor TS; Region: EF_TS; pfam00889 722911002242 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 722911002243 putative nucleotide binding site [chemical binding]; other site 722911002244 uridine monophosphate binding site [chemical binding]; other site 722911002245 homohexameric interface [polypeptide binding]; other site 722911002246 ribosome recycling factor; Reviewed; Region: frr; PRK00083 722911002247 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 722911002248 hinge region; other site 722911002249 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 722911002250 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 722911002251 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 722911002252 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 722911002253 FeS/SAM binding site; other site 722911002254 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 722911002255 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 722911002256 substrate binding site [chemical binding]; other site 722911002257 glutamase interaction surface [polypeptide binding]; other site 722911002258 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 722911002259 anthranilate synthase component I; Provisional; Region: PRK13571 722911002260 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 722911002261 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 722911002262 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 722911002263 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 722911002264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911002265 Walker A/P-loop; other site 722911002266 ATP binding site [chemical binding]; other site 722911002267 Q-loop/lid; other site 722911002268 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 722911002269 ABC transporter signature motif; other site 722911002270 Walker B; other site 722911002271 D-loop; other site 722911002272 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 722911002273 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 722911002274 classical (c) SDRs; Region: SDR_c; cd05233 722911002275 NAD(P) binding site [chemical binding]; other site 722911002276 active site 722911002277 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 722911002278 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 722911002279 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 722911002280 Walker A/P-loop; other site 722911002281 ATP binding site [chemical binding]; other site 722911002282 Q-loop/lid; other site 722911002283 ABC transporter signature motif; other site 722911002284 Walker B; other site 722911002285 D-loop; other site 722911002286 H-loop/switch region; other site 722911002287 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 722911002288 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 722911002289 Walker A/P-loop; other site 722911002290 ATP binding site [chemical binding]; other site 722911002291 Q-loop/lid; other site 722911002292 ABC transporter signature motif; other site 722911002293 Walker B; other site 722911002294 D-loop; other site 722911002295 H-loop/switch region; other site 722911002296 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 722911002297 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 722911002298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 722911002299 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 722911002300 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 722911002301 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 722911002302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 722911002303 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 722911002304 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 722911002305 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 722911002306 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 722911002307 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 722911002308 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 722911002309 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 722911002310 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 722911002311 shikimate binding site; other site 722911002312 NAD(P) binding site [chemical binding]; other site 722911002313 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 722911002314 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 722911002315 Phosphoglycerate kinase; Region: PGK; pfam00162 722911002316 substrate binding site [chemical binding]; other site 722911002317 hinge regions; other site 722911002318 ADP binding site [chemical binding]; other site 722911002319 catalytic site [active] 722911002320 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 722911002321 triosephosphate isomerase; Provisional; Region: PRK14567 722911002322 substrate binding site [chemical binding]; other site 722911002323 dimer interface [polypeptide binding]; other site 722911002324 catalytic triad [active] 722911002325 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 722911002326 tetramer (dimer of dimers) interface [polypeptide binding]; other site 722911002327 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 722911002328 NAD binding site [chemical binding]; other site 722911002329 dimer interface [polypeptide binding]; other site 722911002330 substrate binding site [chemical binding]; other site 722911002331 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 722911002332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 722911002333 non-specific DNA binding site [nucleotide binding]; other site 722911002334 salt bridge; other site 722911002335 sequence-specific DNA binding site [nucleotide binding]; other site 722911002336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 722911002337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911002338 homodimer interface [polypeptide binding]; other site 722911002339 catalytic residue [active] 722911002340 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 722911002341 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 722911002342 putative active site [active] 722911002343 transaldolase; Provisional; Region: PRK03903 722911002344 catalytic residue [active] 722911002345 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 722911002346 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 722911002347 TPP-binding site [chemical binding]; other site 722911002348 dimer interface [polypeptide binding]; other site 722911002349 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 722911002350 PYR/PP interface [polypeptide binding]; other site 722911002351 dimer interface [polypeptide binding]; other site 722911002352 TPP binding site [chemical binding]; other site 722911002353 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 722911002354 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 722911002355 HTH domain; Region: HTH_11; cl17392 722911002356 Fructosamine kinase; Region: Fructosamin_kin; cl17579 722911002357 Phosphotransferase enzyme family; Region: APH; pfam01636 722911002358 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 722911002359 PAC2 family; Region: PAC2; pfam09754 722911002360 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 722911002361 thiS-thiF/thiG interaction site; other site 722911002362 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 722911002363 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 722911002364 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 722911002365 active site 722911002366 dimer interface [polypeptide binding]; other site 722911002367 motif 1; other site 722911002368 motif 2; other site 722911002369 motif 3; other site 722911002370 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 722911002371 anticodon binding site; other site 722911002372 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 722911002373 nucleotide binding site/active site [active] 722911002374 HIT family signature motif; other site 722911002375 catalytic residue [active] 722911002376 hypothetical protein; Validated; Region: PRK00110 722911002377 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 722911002378 RuvA N terminal domain; Region: RuvA_N; pfam01330 722911002379 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 722911002380 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 722911002381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911002382 Walker A motif; other site 722911002383 ATP binding site [chemical binding]; other site 722911002384 Walker B motif; other site 722911002385 arginine finger; other site 722911002386 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 722911002387 Preprotein translocase subunit; Region: YajC; pfam02699 722911002388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 722911002389 active site 722911002390 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 722911002391 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 722911002392 CoA-ligase; Region: Ligase_CoA; pfam00549 722911002393 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 722911002394 CoA binding domain; Region: CoA_binding; smart00881 722911002395 CoA-ligase; Region: Ligase_CoA; pfam00549 722911002396 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 722911002397 amphipathic channel; other site 722911002398 Asn-Pro-Ala signature motifs; other site 722911002399 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 722911002400 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 722911002401 RNA binding surface [nucleotide binding]; other site 722911002402 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 722911002403 active site 722911002404 Predicted transcriptional regulator [Transcription]; Region: COG2378 722911002405 WYL domain; Region: WYL; pfam13280 722911002406 DEAD-like helicases superfamily; Region: DEXDc; smart00487 722911002407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 722911002408 ATP binding site [chemical binding]; other site 722911002409 putative Mg++ binding site [ion binding]; other site 722911002410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 722911002411 nucleotide binding region [chemical binding]; other site 722911002412 ATP-binding site [chemical binding]; other site 722911002413 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 722911002414 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 722911002415 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 722911002416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911002417 motif II; other site 722911002418 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 722911002419 DNA binding residues [nucleotide binding] 722911002420 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 722911002421 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 722911002422 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 722911002423 phosphopeptide binding site; other site 722911002424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 722911002425 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 722911002426 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 722911002427 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 722911002428 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 722911002429 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 722911002430 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 722911002431 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 722911002432 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 722911002433 homodimer interface [polypeptide binding]; other site 722911002434 putative metal binding site [ion binding]; other site 722911002435 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 722911002436 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 722911002437 substrate binding site [chemical binding]; other site 722911002438 hexamer interface [polypeptide binding]; other site 722911002439 metal binding site [ion binding]; metal-binding site 722911002440 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 722911002441 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 722911002442 substrate binding site [chemical binding]; other site 722911002443 active site 722911002444 catalytic residues [active] 722911002445 heterodimer interface [polypeptide binding]; other site 722911002446 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 722911002447 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 722911002448 active site 722911002449 ribulose/triose binding site [chemical binding]; other site 722911002450 phosphate binding site [ion binding]; other site 722911002451 substrate (anthranilate) binding pocket [chemical binding]; other site 722911002452 product (indole) binding pocket [chemical binding]; other site 722911002453 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 722911002454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911002455 catalytic residue [active] 722911002456 endonuclease IV; Provisional; Region: PRK01060 722911002457 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 722911002458 AP (apurinic/apyrimidinic) site pocket; other site 722911002459 DNA interaction; other site 722911002460 Metal-binding active site; metal-binding site 722911002461 S-methylmethionine transporter; Provisional; Region: PRK11387 722911002462 VanZ like family; Region: VanZ; pfam04892 722911002463 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 722911002464 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 722911002465 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 722911002466 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 722911002467 Abi-like protein; Region: Abi_2; pfam07751 722911002468 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 722911002469 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 722911002470 nudix motif; other site 722911002471 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 722911002472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911002473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 722911002474 S-methylmethionine transporter; Provisional; Region: PRK11387 722911002475 Spore germination protein; Region: Spore_permease; cl17796 722911002476 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 722911002477 aspartate aminotransferase; Provisional; Region: PRK06836 722911002478 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 722911002479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911002480 homodimer interface [polypeptide binding]; other site 722911002481 catalytic residue [active] 722911002482 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 722911002483 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 722911002484 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 722911002485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911002486 motif II; other site 722911002487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 722911002488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 722911002489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 722911002490 dimerization interface [polypeptide binding]; other site 722911002491 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 722911002492 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 722911002493 active site 722911002494 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 722911002495 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 722911002496 heterodimer interface [polypeptide binding]; other site 722911002497 active site 722911002498 FMN binding site [chemical binding]; other site 722911002499 homodimer interface [polypeptide binding]; other site 722911002500 substrate binding site [chemical binding]; other site 722911002501 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 722911002502 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 722911002503 FAD binding pocket [chemical binding]; other site 722911002504 FAD binding motif [chemical binding]; other site 722911002505 phosphate binding motif [ion binding]; other site 722911002506 beta-alpha-beta structure motif; other site 722911002507 NAD binding pocket [chemical binding]; other site 722911002508 Iron coordination center [ion binding]; other site 722911002509 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 722911002510 active site 722911002511 dimer interface [polypeptide binding]; other site 722911002512 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 722911002513 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 722911002514 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 722911002515 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 722911002516 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 722911002517 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 722911002518 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 722911002519 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 722911002520 metal binding triad; other site 722911002521 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 722911002522 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 722911002523 metal binding triad; other site 722911002524 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 722911002525 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 722911002526 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 722911002527 active site 722911002528 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 722911002529 FAD binding site [chemical binding]; other site 722911002530 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 722911002531 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 722911002532 THF binding site; other site 722911002533 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 722911002534 substrate binding site [chemical binding]; other site 722911002535 THF binding site; other site 722911002536 zinc-binding site [ion binding]; other site 722911002537 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 722911002538 catalytic core [active] 722911002539 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 722911002540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 722911002541 S-adenosylmethionine binding site [chemical binding]; other site 722911002542 Predicted esterase [General function prediction only]; Region: COG0400 722911002543 putative hydrolase; Provisional; Region: PRK11460 722911002544 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 722911002545 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 722911002546 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 722911002547 active site 722911002548 catalytic tetrad [active] 722911002549 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 722911002550 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 722911002551 SWIM zinc finger; Region: SWIM; pfam04434 722911002552 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 722911002553 Predicted permeases [General function prediction only]; Region: RarD; COG2962 722911002554 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 722911002555 Uncharacterized conserved protein [Function unknown]; Region: COG4715 722911002556 AIPR protein; Region: AIPR; pfam10592 722911002557 Integrase core domain; Region: rve; pfam00665 722911002558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911002559 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 722911002560 active site 722911002561 motif I; other site 722911002562 motif II; other site 722911002563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911002564 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 722911002565 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 722911002566 Walker A/P-loop; other site 722911002567 ATP binding site [chemical binding]; other site 722911002568 Q-loop/lid; other site 722911002569 ABC transporter signature motif; other site 722911002570 Walker B; other site 722911002571 D-loop; other site 722911002572 H-loop/switch region; other site 722911002573 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 722911002574 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 722911002575 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 722911002576 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 722911002577 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 722911002578 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 722911002579 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 722911002580 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911002581 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911002582 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 722911002583 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 722911002584 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 722911002585 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 722911002586 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 722911002587 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 722911002588 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 722911002589 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911002590 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911002591 DNA binding site [nucleotide binding] 722911002592 domain linker motif; other site 722911002593 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911002594 dimerization interface [polypeptide binding]; other site 722911002595 ligand binding site [chemical binding]; other site 722911002596 UPF0126 domain; Region: UPF0126; pfam03458 722911002597 Predicted membrane protein [Function unknown]; Region: COG2860 722911002598 UPF0126 domain; Region: UPF0126; pfam03458 722911002599 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 722911002600 homodimer interface [polypeptide binding]; other site 722911002601 MazG family protein; Region: mazG; TIGR00444 722911002602 metal binding site [ion binding]; metal-binding site 722911002603 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 722911002604 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 722911002605 homodimer interface [polypeptide binding]; other site 722911002606 substrate-cofactor binding pocket; other site 722911002607 catalytic residue [active] 722911002608 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 722911002609 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 722911002610 5S rRNA interface [nucleotide binding]; other site 722911002611 CTC domain interface [polypeptide binding]; other site 722911002612 L16 interface [polypeptide binding]; other site 722911002613 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 722911002614 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 722911002615 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 722911002616 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 722911002617 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 722911002618 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 722911002619 ligand binding site [chemical binding]; other site 722911002620 homodimer interface [polypeptide binding]; other site 722911002621 NAD(P) binding site [chemical binding]; other site 722911002622 trimer interface B [polypeptide binding]; other site 722911002623 trimer interface A [polypeptide binding]; other site 722911002624 GTPase Era; Reviewed; Region: era; PRK00089 722911002625 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 722911002626 G1 box; other site 722911002627 GTP/Mg2+ binding site [chemical binding]; other site 722911002628 Switch I region; other site 722911002629 G2 box; other site 722911002630 Switch II region; other site 722911002631 G3 box; other site 722911002632 G4 box; other site 722911002633 G5 box; other site 722911002634 KH domain; Region: KH_2; pfam07650 722911002635 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 722911002636 Domain of unknown function DUF21; Region: DUF21; pfam01595 722911002637 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 722911002638 Transporter associated domain; Region: CorC_HlyC; smart01091 722911002639 metal-binding heat shock protein; Provisional; Region: PRK00016 722911002640 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 722911002641 nucleotide binding site/active site [active] 722911002642 HIT family signature motif; other site 722911002643 catalytic residue [active] 722911002644 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 722911002645 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 722911002646 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 722911002647 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 722911002648 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 722911002649 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 722911002650 ligand binding site; other site 722911002651 oligomer interface; other site 722911002652 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 722911002653 dimer interface [polypeptide binding]; other site 722911002654 N-terminal domain interface [polypeptide binding]; other site 722911002655 sulfate 1 binding site; other site 722911002656 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 722911002657 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 722911002658 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 722911002659 trimerization site [polypeptide binding]; other site 722911002660 active site 722911002661 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 722911002662 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 722911002663 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 722911002664 catalytic residue [active] 722911002665 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 722911002666 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 722911002667 Walker A/P-loop; other site 722911002668 ATP binding site [chemical binding]; other site 722911002669 Q-loop/lid; other site 722911002670 ABC transporter signature motif; other site 722911002671 Walker B; other site 722911002672 D-loop; other site 722911002673 H-loop/switch region; other site 722911002674 FeS assembly protein SufD; Region: sufD; TIGR01981 722911002675 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 722911002676 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 722911002677 FeS assembly protein SufB; Region: sufB; TIGR01980 722911002678 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 722911002679 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 722911002680 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 722911002681 metal binding site [ion binding]; metal-binding site 722911002682 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 722911002683 Dehydroquinase class II; Region: DHquinase_II; pfam01220 722911002684 trimer interface [polypeptide binding]; other site 722911002685 active site 722911002686 dimer interface [polypeptide binding]; other site 722911002687 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 722911002688 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 722911002689 ADP binding site [chemical binding]; other site 722911002690 magnesium binding site [ion binding]; other site 722911002691 putative shikimate binding site; other site 722911002692 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 722911002693 active site 722911002694 dimer interface [polypeptide binding]; other site 722911002695 metal binding site [ion binding]; metal-binding site 722911002696 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 722911002697 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 722911002698 Tetramer interface [polypeptide binding]; other site 722911002699 active site 722911002700 FMN-binding site [chemical binding]; other site 722911002701 YceG-like family; Region: YceG; pfam02618 722911002702 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 722911002703 dimerization interface [polypeptide binding]; other site 722911002704 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 722911002705 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 722911002706 motif 1; other site 722911002707 active site 722911002708 motif 2; other site 722911002709 motif 3; other site 722911002710 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 722911002711 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 722911002712 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 722911002713 catalytic core [active] 722911002714 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 722911002715 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 722911002716 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 722911002717 RNA binding surface [nucleotide binding]; other site 722911002718 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 722911002719 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 722911002720 Walker A/P-loop; other site 722911002721 ATP binding site [chemical binding]; other site 722911002722 Q-loop/lid; other site 722911002723 ABC transporter signature motif; other site 722911002724 Walker B; other site 722911002725 D-loop; other site 722911002726 H-loop/switch region; other site 722911002727 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 722911002728 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 722911002729 active site 722911002730 xanthine permease; Region: pbuX; TIGR03173 722911002731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 722911002732 salt bridge; other site 722911002733 non-specific DNA binding site [nucleotide binding]; other site 722911002734 sequence-specific DNA binding site [nucleotide binding]; other site 722911002735 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 722911002736 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 722911002737 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 722911002738 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 722911002739 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 722911002740 Isochorismatase family; Region: Isochorismatase; pfam00857 722911002741 catalytic triad [active] 722911002742 metal binding site [ion binding]; metal-binding site 722911002743 conserved cis-peptide bond; other site 722911002744 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 722911002745 Divergent AAA domain; Region: AAA_4; pfam04326 722911002746 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 722911002747 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 722911002748 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 722911002749 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 722911002750 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 722911002751 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 722911002752 Walker A/P-loop; other site 722911002753 ATP binding site [chemical binding]; other site 722911002754 Q-loop/lid; other site 722911002755 ABC transporter signature motif; other site 722911002756 Walker B; other site 722911002757 D-loop; other site 722911002758 H-loop/switch region; other site 722911002759 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 722911002760 Histidine kinase; Region: HisKA_3; pfam07730 722911002761 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 722911002762 ATP binding site [chemical binding]; other site 722911002763 Mg2+ binding site [ion binding]; other site 722911002764 G-X-G motif; other site 722911002765 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 722911002766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 722911002767 active site 722911002768 phosphorylation site [posttranslational modification] 722911002769 intermolecular recognition site; other site 722911002770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 722911002771 DNA binding residues [nucleotide binding] 722911002772 dimerization interface [polypeptide binding]; other site 722911002773 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 722911002774 Protein of unknown function (DUF466); Region: DUF466; cl01082 722911002775 carbon starvation protein A; Provisional; Region: PRK15015 722911002776 Carbon starvation protein CstA; Region: CstA; pfam02554 722911002777 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 722911002778 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 722911002779 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 722911002780 active site 722911002781 catalytic site [active] 722911002782 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 722911002783 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 722911002784 catalytic core [active] 722911002785 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 722911002786 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 722911002787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 722911002788 non-specific DNA binding site [nucleotide binding]; other site 722911002789 salt bridge; other site 722911002790 sequence-specific DNA binding site [nucleotide binding]; other site 722911002791 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 722911002792 Short C-terminal domain; Region: SHOCT; pfam09851 722911002793 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 722911002794 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 722911002795 Catalytic domain of Protein Kinases; Region: PKc; cd00180 722911002796 active site 722911002797 ATP binding site [chemical binding]; other site 722911002798 substrate binding site [chemical binding]; other site 722911002799 activation loop (A-loop); other site 722911002800 hypothetical protein; Provisional; Region: PRK11770 722911002801 Domain of unknown function (DUF307); Region: DUF307; pfam03733 722911002802 Domain of unknown function (DUF307); Region: DUF307; pfam03733 722911002803 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 722911002804 active site 722911002805 metal binding site [ion binding]; metal-binding site 722911002806 hypothetical protein; Provisional; Region: PRK06761 722911002807 AAA domain; Region: AAA_33; pfam13671 722911002808 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 722911002809 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 722911002810 G1 box; other site 722911002811 putative GEF interaction site [polypeptide binding]; other site 722911002812 GTP/Mg2+ binding site [chemical binding]; other site 722911002813 Switch I region; other site 722911002814 G2 box; other site 722911002815 G3 box; other site 722911002816 Switch II region; other site 722911002817 G4 box; other site 722911002818 G5 box; other site 722911002819 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 722911002820 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 722911002821 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 722911002822 Winged helix-turn helix; Region: HTH_29; pfam13551 722911002823 Integrase core domain; Region: rve; pfam00665 722911002824 Integrase core domain; Region: rve_3; pfam13683 722911002825 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 722911002826 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 722911002827 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 722911002828 active site 722911002829 DNA binding site [nucleotide binding] 722911002830 Int/Topo IB signature motif; other site 722911002831 GTP-binding protein YchF; Reviewed; Region: PRK09601 722911002832 YchF GTPase; Region: YchF; cd01900 722911002833 G1 box; other site 722911002834 GTP/Mg2+ binding site [chemical binding]; other site 722911002835 Switch I region; other site 722911002836 G2 box; other site 722911002837 Switch II region; other site 722911002838 G3 box; other site 722911002839 G4 box; other site 722911002840 G5 box; other site 722911002841 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 722911002842 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 722911002843 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 722911002844 Histidine kinase; Region: HisKA_3; pfam07730 722911002845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 722911002846 ATP binding site [chemical binding]; other site 722911002847 Mg2+ binding site [ion binding]; other site 722911002848 G-X-G motif; other site 722911002849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 722911002850 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 722911002851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 722911002852 active site 722911002853 phosphorylation site [posttranslational modification] 722911002854 intermolecular recognition site; other site 722911002855 dimerization interface [polypeptide binding]; other site 722911002856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 722911002857 DNA binding residues [nucleotide binding] 722911002858 dimerization interface [polypeptide binding]; other site 722911002859 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 722911002860 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 722911002861 FtsX-like permease family; Region: FtsX; pfam02687 722911002862 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 722911002863 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 722911002864 Walker A/P-loop; other site 722911002865 ATP binding site [chemical binding]; other site 722911002866 Q-loop/lid; other site 722911002867 ABC transporter signature motif; other site 722911002868 Walker B; other site 722911002869 D-loop; other site 722911002870 H-loop/switch region; other site 722911002871 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 722911002872 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 722911002873 homodimer interface [polypeptide binding]; other site 722911002874 substrate-cofactor binding pocket; other site 722911002875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911002876 catalytic residue [active] 722911002877 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 722911002878 dimer interface [polypeptide binding]; other site 722911002879 pyridoxal binding site [chemical binding]; other site 722911002880 ATP binding site [chemical binding]; other site 722911002881 hypothetical protein; Provisional; Region: PRK14681 722911002882 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 722911002883 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 722911002884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911002885 Walker A motif; other site 722911002886 ATP binding site [chemical binding]; other site 722911002887 Walker B motif; other site 722911002888 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 722911002889 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 722911002890 DNA protecting protein DprA; Region: dprA; TIGR00732 722911002891 L-aspartate oxidase; Provisional; Region: PRK06175 722911002892 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 722911002893 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 722911002894 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 722911002895 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 722911002896 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 722911002897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 722911002898 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 722911002899 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 722911002900 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 722911002901 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 722911002902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911002903 Walker A motif; other site 722911002904 ATP binding site [chemical binding]; other site 722911002905 Walker B motif; other site 722911002906 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 722911002907 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 722911002908 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 722911002909 oligomer interface [polypeptide binding]; other site 722911002910 active site residues [active] 722911002911 Clp protease; Region: CLP_protease; pfam00574 722911002912 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 722911002913 oligomer interface [polypeptide binding]; other site 722911002914 active site residues [active] 722911002915 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 722911002916 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 722911002917 putative ion selectivity filter; other site 722911002918 putative pore gating glutamate residue; other site 722911002919 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 722911002920 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 722911002921 dimer interface [polypeptide binding]; other site 722911002922 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 722911002923 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 722911002924 active site 722911002925 catalytic site [active] 722911002926 substrate binding site [chemical binding]; other site 722911002927 HRDC domain; Region: HRDC; pfam00570 722911002928 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 722911002929 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 722911002930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 722911002931 FeS/SAM binding site; other site 722911002932 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 722911002933 Pyruvate formate lyase 1; Region: PFL1; cd01678 722911002934 coenzyme A binding site [chemical binding]; other site 722911002935 active site 722911002936 catalytic residues [active] 722911002937 glycine loop; other site 722911002938 NAD synthetase; Provisional; Region: PRK13981 722911002939 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 722911002940 multimer interface [polypeptide binding]; other site 722911002941 active site 722911002942 catalytic triad [active] 722911002943 protein interface 1 [polypeptide binding]; other site 722911002944 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 722911002945 homodimer interface [polypeptide binding]; other site 722911002946 NAD binding pocket [chemical binding]; other site 722911002947 ATP binding pocket [chemical binding]; other site 722911002948 Mg binding site [ion binding]; other site 722911002949 active-site loop [active] 722911002950 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 722911002951 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 722911002952 metal binding site [ion binding]; metal-binding site 722911002953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 722911002954 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 722911002955 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 722911002956 Walker A/P-loop; other site 722911002957 ATP binding site [chemical binding]; other site 722911002958 Q-loop/lid; other site 722911002959 ABC transporter signature motif; other site 722911002960 Walker B; other site 722911002961 D-loop; other site 722911002962 H-loop/switch region; other site 722911002963 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 722911002964 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 722911002965 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 722911002966 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 722911002967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911002968 active site 722911002969 motif I; other site 722911002970 motif II; other site 722911002971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 722911002972 putative phosphoketolase; Provisional; Region: PRK05261 722911002973 XFP N-terminal domain; Region: XFP_N; pfam09364 722911002974 XFP C-terminal domain; Region: XFP_C; pfam09363 722911002975 GMP synthase; Reviewed; Region: guaA; PRK00074 722911002976 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 722911002977 AMP/PPi binding site [chemical binding]; other site 722911002978 candidate oxyanion hole; other site 722911002979 catalytic triad [active] 722911002980 potential glutamine specificity residues [chemical binding]; other site 722911002981 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 722911002982 ATP Binding subdomain [chemical binding]; other site 722911002983 Ligand Binding sites [chemical binding]; other site 722911002984 Dimerization subdomain; other site 722911002985 hypothetical protein; Provisional; Region: PRK13663 722911002986 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 722911002987 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 722911002988 active site 722911002989 oxyanion hole [active] 722911002990 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 722911002991 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 722911002992 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 722911002993 active site 722911002994 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 722911002995 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 722911002996 Substrate binding site; other site 722911002997 Mg++ binding site; other site 722911002998 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 722911002999 active site 722911003000 substrate binding site [chemical binding]; other site 722911003001 CoA binding site [chemical binding]; other site 722911003002 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 722911003003 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 722911003004 catalytic core [active] 722911003005 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 722911003006 propionate/acetate kinase; Provisional; Region: PRK12379 722911003007 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 722911003008 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 722911003009 hinge; other site 722911003010 active site 722911003011 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 722911003012 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 722911003013 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 722911003014 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 722911003015 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 722911003016 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 722911003017 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 722911003018 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 722911003019 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 722911003020 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 722911003021 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 722911003022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 722911003023 non-specific DNA binding site [nucleotide binding]; other site 722911003024 salt bridge; other site 722911003025 sequence-specific DNA binding site [nucleotide binding]; other site 722911003026 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 722911003027 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 722911003028 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 722911003029 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 722911003030 active site 722911003031 catalytic site [active] 722911003032 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 722911003033 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 722911003034 dimer interface [polypeptide binding]; other site 722911003035 ADP-ribose binding site [chemical binding]; other site 722911003036 active site 722911003037 nudix motif; other site 722911003038 metal binding site [ion binding]; metal-binding site 722911003039 Uncharacterized conserved protein [Function unknown]; Region: COG0327 722911003040 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 722911003041 DNA polymerase I; Provisional; Region: PRK05755 722911003042 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 722911003043 active site 722911003044 metal binding site 1 [ion binding]; metal-binding site 722911003045 putative 5' ssDNA interaction site; other site 722911003046 metal binding site 3; metal-binding site 722911003047 metal binding site 2 [ion binding]; metal-binding site 722911003048 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 722911003049 putative DNA binding site [nucleotide binding]; other site 722911003050 putative metal binding site [ion binding]; other site 722911003051 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 722911003052 active site 722911003053 substrate binding site [chemical binding]; other site 722911003054 catalytic site [active] 722911003055 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 722911003056 active site 722911003057 DNA binding site [nucleotide binding] 722911003058 catalytic site [active] 722911003059 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 722911003060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 722911003061 active site 722911003062 phosphorylation site [posttranslational modification] 722911003063 intermolecular recognition site; other site 722911003064 dimerization interface [polypeptide binding]; other site 722911003065 ANTAR domain; Region: ANTAR; pfam03861 722911003066 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 722911003067 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 722911003068 dimer interface [polypeptide binding]; other site 722911003069 ADP-ribose binding site [chemical binding]; other site 722911003070 active site 722911003071 nudix motif; other site 722911003072 metal binding site [ion binding]; metal-binding site 722911003073 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 722911003074 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 722911003075 domain interfaces; other site 722911003076 active site 722911003077 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 722911003078 excinuclease ABC subunit B; Provisional; Region: PRK05298 722911003079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 722911003080 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 722911003081 nucleotide binding region [chemical binding]; other site 722911003082 ATP-binding site [chemical binding]; other site 722911003083 Ultra-violet resistance protein B; Region: UvrB; pfam12344 722911003084 UvrB/uvrC motif; Region: UVR; pfam02151 722911003085 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 722911003086 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 722911003087 CoA-binding site [chemical binding]; other site 722911003088 ATP-binding [chemical binding]; other site 722911003089 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 722911003090 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 722911003091 RNA binding site [nucleotide binding]; other site 722911003092 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 722911003093 RNA binding site [nucleotide binding]; other site 722911003094 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 722911003095 RNA binding site [nucleotide binding]; other site 722911003096 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 722911003097 RNA binding site [nucleotide binding]; other site 722911003098 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 722911003099 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 722911003100 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 722911003101 homodimer interface [polypeptide binding]; other site 722911003102 NADP binding site [chemical binding]; other site 722911003103 substrate binding site [chemical binding]; other site 722911003104 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 722911003105 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 722911003106 metal binding site [ion binding]; metal-binding site 722911003107 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 722911003108 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 722911003109 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 722911003110 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 722911003111 ABC-ATPase subunit interface; other site 722911003112 dimer interface [polypeptide binding]; other site 722911003113 putative PBP binding regions; other site 722911003114 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 722911003115 glycogen branching enzyme; Provisional; Region: PRK05402 722911003116 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 722911003117 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 722911003118 active site 722911003119 catalytic site [active] 722911003120 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 722911003121 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 722911003122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 722911003123 active site 722911003124 phosphorylation site [posttranslational modification] 722911003125 intermolecular recognition site; other site 722911003126 dimerization interface [polypeptide binding]; other site 722911003127 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 722911003128 DNA binding site [nucleotide binding] 722911003129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 722911003130 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 722911003131 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 722911003132 dimerization interface [polypeptide binding]; other site 722911003133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 722911003134 dimer interface [polypeptide binding]; other site 722911003135 phosphorylation site [posttranslational modification] 722911003136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 722911003137 ATP binding site [chemical binding]; other site 722911003138 Mg2+ binding site [ion binding]; other site 722911003139 G-X-G motif; other site 722911003140 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 722911003141 Catalytic site [active] 722911003142 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 722911003143 Eukaryotic phosphomannomutase; Region: PMM; cl17107 722911003144 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 722911003145 Transcription factor WhiB; Region: Whib; pfam02467 722911003146 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 722911003147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911003148 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 722911003149 Walker A/P-loop; other site 722911003150 ATP binding site [chemical binding]; other site 722911003151 Transcription factor WhiB; Region: Whib; pfam02467 722911003152 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 722911003153 PAS fold; Region: PAS_4; pfam08448 722911003154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 722911003155 Histidine kinase; Region: HisKA_2; pfam07568 722911003156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 722911003157 ATP binding site [chemical binding]; other site 722911003158 Mg2+ binding site [ion binding]; other site 722911003159 G-X-G motif; other site 722911003160 Haemolysin-III related; Region: HlyIII; pfam03006 722911003161 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 722911003162 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 722911003163 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 722911003164 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 722911003165 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 722911003166 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 722911003167 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 722911003168 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 722911003169 exopolyphosphatase; Region: exo_poly_only; TIGR03706 722911003170 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 722911003171 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 722911003172 Septum formation initiator; Region: DivIC; pfam04977 722911003173 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 722911003174 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 722911003175 active site 722911003176 catalytic tetrad [active] 722911003177 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 722911003178 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 722911003179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 722911003180 ATP binding site [chemical binding]; other site 722911003181 putative Mg++ binding site [ion binding]; other site 722911003182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 722911003183 nucleotide binding region [chemical binding]; other site 722911003184 ATP-binding site [chemical binding]; other site 722911003185 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 722911003186 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 722911003187 putative active site [active] 722911003188 catalytic residue [active] 722911003189 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 722911003190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 722911003191 Coenzyme A binding pocket [chemical binding]; other site 722911003192 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 722911003193 Uncharacterized conserved protein [Function unknown]; Region: COG1615 722911003194 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 722911003195 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 722911003196 putative catalytic cysteine [active] 722911003197 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 722911003198 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 722911003199 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 722911003200 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 722911003201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911003202 catalytic residue [active] 722911003203 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 722911003204 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 722911003205 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 722911003206 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 722911003207 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 722911003208 Soluble P-type ATPase [General function prediction only]; Region: COG4087 722911003209 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 722911003210 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 722911003211 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 722911003212 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 722911003213 Walker A/P-loop; other site 722911003214 ATP binding site [chemical binding]; other site 722911003215 Q-loop/lid; other site 722911003216 ABC transporter signature motif; other site 722911003217 Walker B; other site 722911003218 D-loop; other site 722911003219 H-loop/switch region; other site 722911003220 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 722911003221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911003222 motif II; other site 722911003223 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 722911003224 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 722911003225 Walker A/P-loop; other site 722911003226 ATP binding site [chemical binding]; other site 722911003227 Q-loop/lid; other site 722911003228 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 722911003229 ABC transporter signature motif; other site 722911003230 Walker B; other site 722911003231 D-loop; other site 722911003232 H-loop/switch region; other site 722911003233 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 722911003234 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 722911003235 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 722911003236 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 722911003237 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 722911003238 TrkA-N domain; Region: TrkA_N; pfam02254 722911003239 TrkA-C domain; Region: TrkA_C; pfam02080 722911003240 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 722911003241 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 722911003242 RNA binding surface [nucleotide binding]; other site 722911003243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 722911003244 S-adenosylmethionine binding site [chemical binding]; other site 722911003245 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 722911003246 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911003247 active site 722911003248 motif I; other site 722911003249 motif II; other site 722911003250 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 722911003251 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 722911003252 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 722911003253 active site 722911003254 HIGH motif; other site 722911003255 dimer interface [polypeptide binding]; other site 722911003256 KMSKS motif; other site 722911003257 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 722911003258 RNA binding surface [nucleotide binding]; other site 722911003259 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 722911003260 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 722911003261 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 722911003262 ATP binding site [chemical binding]; other site 722911003263 substrate interface [chemical binding]; other site 722911003264 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 722911003265 ThiS interaction site; other site 722911003266 putative active site [active] 722911003267 tetramer interface [polypeptide binding]; other site 722911003268 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 722911003269 thiS-thiF/thiG interaction site; other site 722911003270 argininosuccinate lyase; Provisional; Region: PRK00855 722911003271 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 722911003272 active sites [active] 722911003273 tetramer interface [polypeptide binding]; other site 722911003274 argininosuccinate synthase; Provisional; Region: PRK13820 722911003275 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 722911003276 ANP binding site [chemical binding]; other site 722911003277 Substrate Binding Site II [chemical binding]; other site 722911003278 Substrate Binding Site I [chemical binding]; other site 722911003279 arginine repressor; Provisional; Region: PRK03341 722911003280 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 722911003281 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 722911003282 ornithine carbamoyltransferase; Provisional; Region: PRK00779 722911003283 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 722911003284 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 722911003285 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 722911003286 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 722911003287 inhibitor-cofactor binding pocket; inhibition site 722911003288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911003289 catalytic residue [active] 722911003290 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 722911003291 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 722911003292 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 722911003293 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 722911003294 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 722911003295 putative tRNA-binding site [nucleotide binding]; other site 722911003296 B3/4 domain; Region: B3_4; pfam03483 722911003297 tRNA synthetase B5 domain; Region: B5; smart00874 722911003298 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 722911003299 dimer interface [polypeptide binding]; other site 722911003300 motif 1; other site 722911003301 motif 3; other site 722911003302 motif 2; other site 722911003303 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 722911003304 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 722911003305 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 722911003306 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 722911003307 dimer interface [polypeptide binding]; other site 722911003308 motif 1; other site 722911003309 active site 722911003310 motif 2; other site 722911003311 motif 3; other site 722911003312 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 722911003313 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 722911003314 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 722911003315 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 722911003316 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 722911003317 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 722911003318 Walker A/P-loop; other site 722911003319 ATP binding site [chemical binding]; other site 722911003320 Q-loop/lid; other site 722911003321 ABC transporter signature motif; other site 722911003322 Walker B; other site 722911003323 D-loop; other site 722911003324 H-loop/switch region; other site 722911003325 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 722911003326 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 722911003327 Walker A/P-loop; other site 722911003328 ATP binding site [chemical binding]; other site 722911003329 Q-loop/lid; other site 722911003330 ABC transporter signature motif; other site 722911003331 Walker B; other site 722911003332 D-loop; other site 722911003333 H-loop/switch region; other site 722911003334 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 722911003335 hypothetical protein; Provisional; Region: PRK07907 722911003336 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 722911003337 active site 722911003338 metal binding site [ion binding]; metal-binding site 722911003339 dimer interface [polypeptide binding]; other site 722911003340 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 722911003341 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 722911003342 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 722911003343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 722911003344 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 722911003345 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 722911003346 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 722911003347 Predicted permeases [General function prediction only]; Region: COG0679 722911003348 maltose O-acetyltransferase; Provisional; Region: PRK10092 722911003349 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 722911003350 active site 722911003351 substrate binding site [chemical binding]; other site 722911003352 trimer interface [polypeptide binding]; other site 722911003353 CoA binding site [chemical binding]; other site 722911003354 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 722911003355 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 722911003356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911003357 Walker A/P-loop; other site 722911003358 ATP binding site [chemical binding]; other site 722911003359 Q-loop/lid; other site 722911003360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911003361 ABC transporter signature motif; other site 722911003362 Walker B; other site 722911003363 D-loop; other site 722911003364 H-loop/switch region; other site 722911003365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911003366 Walker A/P-loop; other site 722911003367 ATP binding site [chemical binding]; other site 722911003368 Q-loop/lid; other site 722911003369 ABC transporter signature motif; other site 722911003370 Walker B; other site 722911003371 D-loop; other site 722911003372 H-loop/switch region; other site 722911003373 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 722911003374 AAA domain; Region: AAA_14; pfam13173 722911003375 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 722911003376 KDPG and KHG aldolase; Region: Aldolase; cl17259 722911003377 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 722911003378 MarR family; Region: MarR_2; pfam12802 722911003379 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 722911003380 AAA domain; Region: AAA_14; pfam13173 722911003381 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 722911003382 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 722911003383 catalytic Zn binding site [ion binding]; other site 722911003384 NAD(P) binding site [chemical binding]; other site 722911003385 structural Zn binding site [ion binding]; other site 722911003386 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 722911003387 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 722911003388 DNA binding residues [nucleotide binding] 722911003389 putative dimer interface [polypeptide binding]; other site 722911003390 CrcB-like protein; Region: CRCB; pfam02537 722911003391 CrcB-like protein; Region: CRCB; pfam02537 722911003392 Predicted membrane protein [Function unknown]; Region: COG2246 722911003393 GtrA-like protein; Region: GtrA; pfam04138 722911003394 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 722911003395 Transcriptional regulator [Transcription]; Region: LysR; COG0583 722911003396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 722911003397 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 722911003398 dimerization interface [polypeptide binding]; other site 722911003399 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 722911003400 elongation factor Tu; Reviewed; Region: PRK00049 722911003401 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 722911003402 G1 box; other site 722911003403 GEF interaction site [polypeptide binding]; other site 722911003404 GTP/Mg2+ binding site [chemical binding]; other site 722911003405 Switch I region; other site 722911003406 G2 box; other site 722911003407 G3 box; other site 722911003408 Switch II region; other site 722911003409 G4 box; other site 722911003410 G5 box; other site 722911003411 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 722911003412 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 722911003413 Antibiotic Binding Site [chemical binding]; other site 722911003414 elongation factor G; Reviewed; Region: PRK00007 722911003415 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 722911003416 G1 box; other site 722911003417 putative GEF interaction site [polypeptide binding]; other site 722911003418 GTP/Mg2+ binding site [chemical binding]; other site 722911003419 Switch I region; other site 722911003420 G2 box; other site 722911003421 G3 box; other site 722911003422 Switch II region; other site 722911003423 G4 box; other site 722911003424 G5 box; other site 722911003425 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 722911003426 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 722911003427 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 722911003428 30S ribosomal protein S7; Validated; Region: PRK05302 722911003429 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 722911003430 Sodium Bile acid symporter family; Region: SBF; pfam01758 722911003431 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 722911003432 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 722911003433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 722911003434 catalytic residue [active] 722911003435 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 722911003436 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 722911003437 putative ADP-binding pocket [chemical binding]; other site 722911003438 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 722911003439 ATP-grasp domain; Region: ATP-grasp; pfam02222 722911003440 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 722911003441 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 722911003442 ATP binding site [chemical binding]; other site 722911003443 active site 722911003444 substrate binding site [chemical binding]; other site 722911003445 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 722911003446 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 722911003447 dimerization interface [polypeptide binding]; other site 722911003448 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 722911003449 dimerization interface [polypeptide binding]; other site 722911003450 ATP binding site [chemical binding]; other site 722911003451 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 722911003452 dimerization interface [polypeptide binding]; other site 722911003453 ATP binding site [chemical binding]; other site 722911003454 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 722911003455 putative active site [active] 722911003456 catalytic triad [active] 722911003457 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 722911003458 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 722911003459 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 722911003460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 722911003461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 722911003462 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 722911003463 dimerization interface [polypeptide binding]; other site 722911003464 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 722911003465 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 722911003466 active site 722911003467 catalytic tetrad [active] 722911003468 DNA polymerase IV; Reviewed; Region: PRK03103 722911003469 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 722911003470 active site 722911003471 DNA binding site [nucleotide binding] 722911003472 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 722911003473 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 722911003474 NAD binding site [chemical binding]; other site 722911003475 guanine deaminase; Region: guan_deamin; TIGR02967 722911003476 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 722911003477 active site 722911003478 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 722911003479 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 722911003480 substrate binding pocket [chemical binding]; other site 722911003481 membrane-bound complex binding site; other site 722911003482 hinge residues; other site 722911003483 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 722911003484 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 722911003485 Walker A/P-loop; other site 722911003486 ATP binding site [chemical binding]; other site 722911003487 Q-loop/lid; other site 722911003488 ABC transporter signature motif; other site 722911003489 Walker B; other site 722911003490 D-loop; other site 722911003491 H-loop/switch region; other site 722911003492 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 722911003493 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 722911003494 dimerization interface [polypeptide binding]; other site 722911003495 putative ATP binding site [chemical binding]; other site 722911003496 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 722911003497 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 722911003498 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 722911003499 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 722911003500 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 722911003501 NAD(P) binding site [chemical binding]; other site 722911003502 catalytic residues [active] 722911003503 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 722911003504 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 722911003505 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 722911003506 metal binding site [ion binding]; metal-binding site 722911003507 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 722911003508 metal binding site 2 [ion binding]; metal-binding site 722911003509 putative DNA binding helix; other site 722911003510 metal binding site 1 [ion binding]; metal-binding site 722911003511 dimer interface [polypeptide binding]; other site 722911003512 structural Zn2+ binding site [ion binding]; other site 722911003513 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 722911003514 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 722911003515 NAD binding site [chemical binding]; other site 722911003516 ATP-grasp domain; Region: ATP-grasp; pfam02222 722911003517 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 722911003518 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 722911003519 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 722911003520 NAD(P) binding site [chemical binding]; other site 722911003521 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 722911003522 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 722911003523 TPP-binding site; other site 722911003524 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 722911003525 PYR/PP interface [polypeptide binding]; other site 722911003526 dimer interface [polypeptide binding]; other site 722911003527 TPP binding site [chemical binding]; other site 722911003528 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 722911003529 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 722911003530 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 722911003531 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 722911003532 transmembrane helices; other site 722911003533 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 722911003534 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 722911003535 catalytic nucleophile [active] 722911003536 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 722911003537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 722911003538 DNA-binding site [nucleotide binding]; DNA binding site 722911003539 Rhoptry-associated protein 1 (RAP-1); Region: RAP1; pfam07218 722911003540 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 722911003541 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 722911003542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911003543 homodimer interface [polypeptide binding]; other site 722911003544 catalytic residue [active] 722911003545 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 722911003546 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 722911003547 predicted active site [active] 722911003548 catalytic triad [active] 722911003549 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 722911003550 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 722911003551 active site 722911003552 multimer interface [polypeptide binding]; other site 722911003553 DNA primase; Validated; Region: dnaG; PRK05667 722911003554 CHC2 zinc finger; Region: zf-CHC2; cl17510 722911003555 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 722911003556 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 722911003557 active site 722911003558 metal binding site [ion binding]; metal-binding site 722911003559 interdomain interaction site; other site 722911003560 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 722911003561 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 722911003562 alanine racemase; Reviewed; Region: alr; PRK00053 722911003563 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 722911003564 active site 722911003565 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 722911003566 dimer interface [polypeptide binding]; other site 722911003567 substrate binding site [chemical binding]; other site 722911003568 catalytic residues [active] 722911003569 amino acid transporter; Region: 2A0306; TIGR00909 722911003570 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 722911003571 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 722911003572 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 722911003573 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 722911003574 S-ribosylhomocysteinase; Provisional; Region: PRK02260 722911003575 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 722911003576 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 722911003577 ATP binding site [chemical binding]; other site 722911003578 putative Mg++ binding site [ion binding]; other site 722911003579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 722911003580 nucleotide binding region [chemical binding]; other site 722911003581 ATP-binding site [chemical binding]; other site 722911003582 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 722911003583 HRDC domain; Region: HRDC; pfam00570 722911003584 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 722911003585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 722911003586 cystathionine gamma-synthase; Provisional; Region: PRK07811 722911003587 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 722911003588 homodimer interface [polypeptide binding]; other site 722911003589 substrate-cofactor binding pocket; other site 722911003590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911003591 catalytic residue [active] 722911003592 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 722911003593 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 722911003594 dimer interface [polypeptide binding]; other site 722911003595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911003596 catalytic residue [active] 722911003597 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 722911003598 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 722911003599 Walker A/P-loop; other site 722911003600 ATP binding site [chemical binding]; other site 722911003601 Q-loop/lid; other site 722911003602 ABC transporter signature motif; other site 722911003603 Walker B; other site 722911003604 D-loop; other site 722911003605 H-loop/switch region; other site 722911003606 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 722911003607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911003608 ABC-ATPase subunit interface; other site 722911003609 putative PBP binding loops; other site 722911003610 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 722911003611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911003612 putative PBP binding loops; other site 722911003613 dimer interface [polypeptide binding]; other site 722911003614 ABC-ATPase subunit interface; other site 722911003615 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 722911003616 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 722911003617 pantothenate kinase; Reviewed; Region: PRK13318 722911003618 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 722911003619 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911003620 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 722911003621 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911003622 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 722911003623 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911003624 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 722911003625 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 722911003626 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 722911003627 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911003628 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911003629 DNA binding site [nucleotide binding] 722911003630 domain linker motif; other site 722911003631 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911003632 ligand binding site [chemical binding]; other site 722911003633 dimerization interface [polypeptide binding]; other site 722911003634 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 722911003635 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 722911003636 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 722911003637 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911003638 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911003639 DNA binding site [nucleotide binding] 722911003640 domain linker motif; other site 722911003641 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 722911003642 ligand binding site [chemical binding]; other site 722911003643 dimerization interface (open form) [polypeptide binding]; other site 722911003644 dimerization interface (closed form) [polypeptide binding]; other site 722911003645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 722911003646 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 722911003647 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 722911003648 active site 722911003649 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 722911003650 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 722911003651 Walker A/P-loop; other site 722911003652 ATP binding site [chemical binding]; other site 722911003653 Q-loop/lid; other site 722911003654 ABC transporter signature motif; other site 722911003655 Walker B; other site 722911003656 D-loop; other site 722911003657 H-loop/switch region; other site 722911003658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911003659 dimer interface [polypeptide binding]; other site 722911003660 conserved gate region; other site 722911003661 putative PBP binding loops; other site 722911003662 ABC-ATPase subunit interface; other site 722911003663 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 722911003664 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 722911003665 substrate binding pocket [chemical binding]; other site 722911003666 membrane-bound complex binding site; other site 722911003667 hinge residues; other site 722911003668 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 722911003669 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 722911003670 substrate binding pocket [chemical binding]; other site 722911003671 membrane-bound complex binding site; other site 722911003672 hinge residues; other site 722911003673 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 722911003674 SmpB-tmRNA interface; other site 722911003675 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 722911003676 FtsX-like permease family; Region: FtsX; pfam02687 722911003677 peptide chain release factor 2; Validated; Region: prfB; PRK00578 722911003678 This domain is found in peptide chain release factors; Region: PCRF; smart00937 722911003679 RF-1 domain; Region: RF-1; pfam00472 722911003680 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 722911003681 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 722911003682 active site 722911003683 substrate binding site [chemical binding]; other site 722911003684 catalytic site [active] 722911003685 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 722911003686 active site 722911003687 catalytic residues [active] 722911003688 metal binding site [ion binding]; metal-binding site 722911003689 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 722911003690 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 722911003691 active site 722911003692 substrate binding site [chemical binding]; other site 722911003693 metal binding site [ion binding]; metal-binding site 722911003694 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 722911003695 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 722911003696 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 722911003697 Zn binding site [ion binding]; other site 722911003698 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 722911003699 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 722911003700 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 722911003701 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 722911003702 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 722911003703 dimer interface [polypeptide binding]; other site 722911003704 active site 722911003705 catalytic residue [active] 722911003706 dihydrodipicolinate reductase; Provisional; Region: PRK00048 722911003707 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 722911003708 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 722911003709 Major Facilitator Superfamily; Region: MFS_1; pfam07690 722911003710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911003711 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 722911003712 Family description; Region: UvrD_C_2; pfam13538 722911003713 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 722911003714 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 722911003715 Catalytic domain of Protein Kinases; Region: PKc; cd00180 722911003716 active site 722911003717 ATP binding site [chemical binding]; other site 722911003718 substrate binding site [chemical binding]; other site 722911003719 activation loop (A-loop); other site 722911003720 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 722911003721 Interdomain contacts; other site 722911003722 Cytokine receptor motif; other site 722911003723 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 722911003724 Interdomain contacts; other site 722911003725 Cytokine receptor motif; other site 722911003726 MoxR-like ATPases [General function prediction only]; Region: COG0714 722911003727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911003728 Walker A motif; other site 722911003729 ATP binding site [chemical binding]; other site 722911003730 Walker B motif; other site 722911003731 arginine finger; other site 722911003732 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 722911003733 Protein of unknown function DUF58; Region: DUF58; pfam01882 722911003734 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 722911003735 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 722911003736 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 722911003737 active site 722911003738 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 722911003739 phosphopeptide binding site; other site 722911003740 Alphaherpesvirus tegument protein US9; Region: Herpes_US9; pfam06072 722911003741 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 722911003742 minor groove reading motif; other site 722911003743 helix-hairpin-helix signature motif; other site 722911003744 active site 722911003745 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 722911003746 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 722911003747 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 722911003748 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 722911003749 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 722911003750 galactokinase; Provisional; Region: PRK05322 722911003751 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 722911003752 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 722911003753 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 722911003754 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 722911003755 dimer interface [polypeptide binding]; other site 722911003756 active site 722911003757 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 722911003758 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 722911003759 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 722911003760 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 722911003761 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 722911003762 quinone interaction residues [chemical binding]; other site 722911003763 active site 722911003764 catalytic residues [active] 722911003765 FMN binding site [chemical binding]; other site 722911003766 substrate binding site [chemical binding]; other site 722911003767 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 722911003768 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 722911003769 active site 722911003770 FMN binding site [chemical binding]; other site 722911003771 substrate binding site [chemical binding]; other site 722911003772 homotetramer interface [polypeptide binding]; other site 722911003773 catalytic residue [active] 722911003774 Transglycosylase; Region: Transgly; pfam00912 722911003775 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 722911003776 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 722911003777 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 722911003778 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 722911003779 ligand binding site [chemical binding]; other site 722911003780 flexible hinge region; other site 722911003781 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 722911003782 putative switch regulator; other site 722911003783 non-specific DNA interactions [nucleotide binding]; other site 722911003784 DNA binding site [nucleotide binding] 722911003785 sequence specific DNA binding site [nucleotide binding]; other site 722911003786 putative cAMP binding site [chemical binding]; other site 722911003787 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 722911003788 tartrate dehydrogenase; Region: TTC; TIGR02089 722911003789 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 722911003790 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 722911003791 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 722911003792 Uncharacterized conserved protein [Function unknown]; Region: COG4850 722911003793 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 722911003794 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 722911003795 lipoyl attachment site [posttranslational modification]; other site 722911003796 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 722911003797 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 722911003798 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 722911003799 putative NADH binding site [chemical binding]; other site 722911003800 putative active site [active] 722911003801 nudix motif; other site 722911003802 putative metal binding site [ion binding]; other site 722911003803 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 722911003804 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 722911003805 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 722911003806 catalytic residues [active] 722911003807 Domain of unknown function (DUF348); Region: DUF348; pfam03990 722911003808 G5 domain; Region: G5; pfam07501 722911003809 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 722911003810 N-acetyl-D-glucosamine binding site [chemical binding]; other site 722911003811 catalytic residue [active] 722911003812 AAA domain; Region: AAA_21; pfam13304 722911003813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911003814 Walker B; other site 722911003815 D-loop; other site 722911003816 H-loop/switch region; other site 722911003817 RloB-like protein; Region: RloB; pfam13707 722911003818 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 722911003819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 722911003820 non-specific DNA binding site [nucleotide binding]; other site 722911003821 salt bridge; other site 722911003822 sequence-specific DNA binding site [nucleotide binding]; other site 722911003823 HTH-like domain; Region: HTH_21; pfam13276 722911003824 Integrase core domain; Region: rve; pfam00665 722911003825 Transposase; Region: HTH_Tnp_1; pfam01527 722911003826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 722911003827 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 722911003828 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 722911003829 dimer interface [polypeptide binding]; other site 722911003830 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 722911003831 TPP-binding site [chemical binding]; other site 722911003832 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 722911003833 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 722911003834 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 722911003835 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 722911003836 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 722911003837 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 722911003838 Helix-turn-helix domain; Region: HTH_38; pfam13936 722911003839 Integrase core domain; Region: rve; pfam00665 722911003840 Low molecular weight phosphatase family; Region: LMWPc; cd00115 722911003841 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 722911003842 active site 722911003843 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 722911003844 Bacterial sugar transferase; Region: Bac_transf; pfam02397 722911003845 Transposase; Region: HTH_Tnp_1; cl17663 722911003846 HTH-like domain; Region: HTH_21; pfam13276 722911003847 Integrase core domain; Region: rve; pfam00665 722911003848 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 722911003849 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 722911003850 AAA domain; Region: AAA_14; pfam13173 722911003851 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 722911003852 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 722911003853 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 722911003854 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 722911003855 active site 722911003856 catalytic tetrad [active] 722911003857 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 722911003858 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 722911003859 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 722911003860 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911003861 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911003862 DNA binding site [nucleotide binding] 722911003863 domain linker motif; other site 722911003864 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911003865 ligand binding site [chemical binding]; other site 722911003866 dimerization interface [polypeptide binding]; other site 722911003867 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 722911003868 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 722911003869 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 722911003870 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 722911003871 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 722911003872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911003873 dimer interface [polypeptide binding]; other site 722911003874 conserved gate region; other site 722911003875 putative PBP binding loops; other site 722911003876 ABC-ATPase subunit interface; other site 722911003877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911003878 dimer interface [polypeptide binding]; other site 722911003879 conserved gate region; other site 722911003880 putative PBP binding loops; other site 722911003881 ABC-ATPase subunit interface; other site 722911003882 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 722911003883 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911003884 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 722911003885 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 722911003886 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 722911003887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911003888 Walker A/P-loop; other site 722911003889 ATP binding site [chemical binding]; other site 722911003890 Q-loop/lid; other site 722911003891 ABC transporter signature motif; other site 722911003892 Walker B; other site 722911003893 D-loop; other site 722911003894 H-loop/switch region; other site 722911003895 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 722911003896 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 722911003897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911003898 Walker A/P-loop; other site 722911003899 ATP binding site [chemical binding]; other site 722911003900 Q-loop/lid; other site 722911003901 ABC transporter signature motif; other site 722911003902 Walker B; other site 722911003903 D-loop; other site 722911003904 H-loop/switch region; other site 722911003905 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 722911003906 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 722911003907 acyl-activating enzyme (AAE) consensus motif; other site 722911003908 putative AMP binding site [chemical binding]; other site 722911003909 putative active site [active] 722911003910 putative CoA binding site [chemical binding]; other site 722911003911 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 722911003912 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 722911003913 Walker A/P-loop; other site 722911003914 ATP binding site [chemical binding]; other site 722911003915 Q-loop/lid; other site 722911003916 ABC transporter signature motif; other site 722911003917 Walker B; other site 722911003918 D-loop; other site 722911003919 H-loop/switch region; other site 722911003920 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 722911003921 FtsX-like permease family; Region: FtsX; pfam02687 722911003922 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 722911003923 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 722911003924 FtsX-like permease family; Region: FtsX; pfam02687 722911003925 Peptidase C26; Region: Peptidase_C26; pfam07722 722911003926 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 722911003927 catalytic triad [active] 722911003928 L-arabinose isomerase; Provisional; Region: PRK02929 722911003929 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 722911003930 hexamer (dimer of trimers) interface [polypeptide binding]; other site 722911003931 trimer interface [polypeptide binding]; other site 722911003932 substrate binding site [chemical binding]; other site 722911003933 Mn binding site [ion binding]; other site 722911003934 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 722911003935 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 722911003936 intersubunit interface [polypeptide binding]; other site 722911003937 active site 722911003938 Zn2+ binding site [ion binding]; other site 722911003939 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 722911003940 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 722911003941 putative N- and C-terminal domain interface [polypeptide binding]; other site 722911003942 putative active site [active] 722911003943 MgATP binding site [chemical binding]; other site 722911003944 catalytic site [active] 722911003945 metal binding site [ion binding]; metal-binding site 722911003946 putative carbohydrate binding site [chemical binding]; other site 722911003947 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911003948 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911003949 DNA binding site [nucleotide binding] 722911003950 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 722911003951 ligand binding site [chemical binding]; other site 722911003952 dimerization interface (open form) [polypeptide binding]; other site 722911003953 dimerization interface (closed form) [polypeptide binding]; other site 722911003954 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 722911003955 RNA/DNA hybrid binding site [nucleotide binding]; other site 722911003956 active site 722911003957 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 722911003958 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 722911003959 Catalytic site [active] 722911003960 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 722911003961 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 722911003962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911003963 dimer interface [polypeptide binding]; other site 722911003964 conserved gate region; other site 722911003965 putative PBP binding loops; other site 722911003966 ABC-ATPase subunit interface; other site 722911003967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911003968 dimer interface [polypeptide binding]; other site 722911003969 conserved gate region; other site 722911003970 putative PBP binding loops; other site 722911003971 ABC-ATPase subunit interface; other site 722911003972 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 722911003973 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 722911003974 Walker A/P-loop; other site 722911003975 ATP binding site [chemical binding]; other site 722911003976 Q-loop/lid; other site 722911003977 ABC transporter signature motif; other site 722911003978 Walker B; other site 722911003979 D-loop; other site 722911003980 H-loop/switch region; other site 722911003981 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 722911003982 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 722911003983 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 722911003984 active site 722911003985 dimer interface [polypeptide binding]; other site 722911003986 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 722911003987 dimer interface [polypeptide binding]; other site 722911003988 active site 722911003989 Membrane transport protein; Region: Mem_trans; cl09117 722911003990 FemAB family; Region: FemAB; pfam02388 722911003991 FemAB family; Region: FemAB; pfam02388 722911003992 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 722911003993 active site 722911003994 dimerization interface [polypeptide binding]; other site 722911003995 ribonuclease PH; Reviewed; Region: rph; PRK00173 722911003996 Ribonuclease PH; Region: RNase_PH_bact; cd11362 722911003997 hexamer interface [polypeptide binding]; other site 722911003998 active site 722911003999 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 722911004000 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 722911004001 active site 722911004002 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 722911004003 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 722911004004 DNA binding residues [nucleotide binding] 722911004005 putative dimer interface [polypeptide binding]; other site 722911004006 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 722911004007 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 722911004008 active site 722911004009 catalytic tetrad [active] 722911004010 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 722911004011 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 722911004012 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 722911004013 active site 722911004014 (T/H)XGH motif; other site 722911004015 DivIVA protein; Region: DivIVA; pfam05103 722911004016 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 722911004017 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 722911004018 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 722911004019 ribonuclease III; Reviewed; Region: rnc; PRK00102 722911004020 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 722911004021 dimerization interface [polypeptide binding]; other site 722911004022 active site 722911004023 metal binding site [ion binding]; metal-binding site 722911004024 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 722911004025 dsRNA binding site [nucleotide binding]; other site 722911004026 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 722911004027 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 722911004028 putative valine binding site [chemical binding]; other site 722911004029 dimer interface [polypeptide binding]; other site 722911004030 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 722911004031 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 722911004032 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 722911004033 oligomeric interface; other site 722911004034 putative active site [active] 722911004035 homodimer interface [polypeptide binding]; other site 722911004036 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 722911004037 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 722911004038 ABC transporter; Region: ABC_tran_2; pfam12848 722911004039 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 722911004040 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 722911004041 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 722911004042 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 722911004043 active site 722911004044 HIGH motif; other site 722911004045 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 722911004046 KMSKS motif; other site 722911004047 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 722911004048 tRNA binding surface [nucleotide binding]; other site 722911004049 anticodon binding site; other site 722911004050 Cation efflux family; Region: Cation_efflux; pfam01545 722911004051 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 722911004052 putative catalytic site [active] 722911004053 putative metal binding site [ion binding]; other site 722911004054 putative phosphate binding site [ion binding]; other site 722911004055 hypothetical protein; Provisional; Region: PRK02821 722911004056 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 722911004057 G-X-X-G motif; other site 722911004058 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 722911004059 RimM N-terminal domain; Region: RimM; pfam01782 722911004060 HipA N-terminal domain; Region: Couple_hipA; cl11853 722911004061 HipA-like N-terminal domain; Region: HipA_N; pfam07805 722911004062 HipA-like C-terminal domain; Region: HipA_C; pfam07804 722911004063 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 722911004064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911004065 dimer interface [polypeptide binding]; other site 722911004066 conserved gate region; other site 722911004067 putative PBP binding loops; other site 722911004068 ABC-ATPase subunit interface; other site 722911004069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911004070 dimer interface [polypeptide binding]; other site 722911004071 conserved gate region; other site 722911004072 putative PBP binding loops; other site 722911004073 ABC-ATPase subunit interface; other site 722911004074 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 722911004075 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911004076 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911004077 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911004078 DNA binding site [nucleotide binding] 722911004079 domain linker motif; other site 722911004080 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911004081 dimerization interface [polypeptide binding]; other site 722911004082 ligand binding site [chemical binding]; other site 722911004083 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 722911004084 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 722911004085 active site 722911004086 catalytic tetrad [active] 722911004087 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 722911004088 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 722911004089 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 722911004090 Walker A/P-loop; other site 722911004091 ATP binding site [chemical binding]; other site 722911004092 Q-loop/lid; other site 722911004093 ABC transporter signature motif; other site 722911004094 Walker B; other site 722911004095 D-loop; other site 722911004096 H-loop/switch region; other site 722911004097 sulfate transport protein; Provisional; Region: cysT; CHL00187 722911004098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911004099 dimer interface [polypeptide binding]; other site 722911004100 conserved gate region; other site 722911004101 putative PBP binding loops; other site 722911004102 ABC-ATPase subunit interface; other site 722911004103 PBP superfamily domain; Region: PBP_like_2; cl17296 722911004104 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 722911004105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 722911004106 active site 722911004107 phosphorylation site [posttranslational modification] 722911004108 intermolecular recognition site; other site 722911004109 dimerization interface [polypeptide binding]; other site 722911004110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 722911004111 DNA binding site [nucleotide binding] 722911004112 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 722911004113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 722911004114 dimer interface [polypeptide binding]; other site 722911004115 phosphorylation site [posttranslational modification] 722911004116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 722911004117 ATP binding site [chemical binding]; other site 722911004118 Mg2+ binding site [ion binding]; other site 722911004119 G-X-G motif; other site 722911004120 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 722911004121 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 722911004122 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 722911004123 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 722911004124 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 722911004125 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 722911004126 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 722911004127 trimer interface [polypeptide binding]; other site 722911004128 active site 722911004129 G bulge; other site 722911004130 DivIVA protein; Region: DivIVA; pfam05103 722911004131 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 722911004132 putative substrate binding pocket [chemical binding]; other site 722911004133 AC domain interface; other site 722911004134 catalytic triad [active] 722911004135 AB domain interface; other site 722911004136 interchain disulfide; other site 722911004137 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 722911004138 substrate binding site; other site 722911004139 dimer interface; other site 722911004140 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 722911004141 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 722911004142 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 722911004143 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 722911004144 Peptidase family U32; Region: Peptidase_U32; pfam01136 722911004145 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 722911004146 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 722911004147 ssDNA binding site; other site 722911004148 generic binding surface II; other site 722911004149 DEAD-like helicases superfamily; Region: DEXDc; smart00487 722911004150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 722911004151 ATP binding site [chemical binding]; other site 722911004152 putative Mg++ binding site [ion binding]; other site 722911004153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 722911004154 nucleotide binding region [chemical binding]; other site 722911004155 ATP-binding site [chemical binding]; other site 722911004156 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 722911004157 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 722911004158 substrate binding site [chemical binding]; other site 722911004159 ATP binding site [chemical binding]; other site 722911004160 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 722911004161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911004162 putative substrate translocation pore; other site 722911004163 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 722911004164 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 722911004165 DNA binding residues [nucleotide binding] 722911004166 dimer interface [polypeptide binding]; other site 722911004167 RelB antitoxin; Region: RelB; cl01171 722911004168 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 722911004169 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 722911004170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 722911004171 non-specific DNA binding site [nucleotide binding]; other site 722911004172 salt bridge; other site 722911004173 sequence-specific DNA binding site [nucleotide binding]; other site 722911004174 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 722911004175 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 722911004176 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 722911004177 DNA binding site [nucleotide binding] 722911004178 active site 722911004179 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 722911004180 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 722911004181 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 722911004182 Aspartase; Region: Aspartase; cd01357 722911004183 active sites [active] 722911004184 tetramer interface [polypeptide binding]; other site 722911004185 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 722911004186 Mechanosensitive ion channel; Region: MS_channel; pfam00924 722911004187 CAAX protease self-immunity; Region: Abi; pfam02517 722911004188 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 722911004189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911004190 Walker A/P-loop; other site 722911004191 ATP binding site [chemical binding]; other site 722911004192 Q-loop/lid; other site 722911004193 ABC transporter signature motif; other site 722911004194 Walker B; other site 722911004195 D-loop; other site 722911004196 H-loop/switch region; other site 722911004197 TOBE domain; Region: TOBE_2; pfam08402 722911004198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911004199 dimer interface [polypeptide binding]; other site 722911004200 conserved gate region; other site 722911004201 putative PBP binding loops; other site 722911004202 ABC-ATPase subunit interface; other site 722911004203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 722911004204 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 722911004205 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 722911004206 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 722911004207 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 722911004208 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 722911004209 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 722911004210 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 722911004211 putative acyl-acceptor binding pocket; other site 722911004212 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 722911004213 homotrimer interaction site [polypeptide binding]; other site 722911004214 putative active site [active] 722911004215 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 722911004216 putative active site [active] 722911004217 putative metal binding residues [ion binding]; other site 722911004218 signature motif; other site 722911004219 putative dimer interface [polypeptide binding]; other site 722911004220 putative phosphate binding site [ion binding]; other site 722911004221 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 722911004222 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 722911004223 hypothetical protein; Provisional; Region: PRK03298 722911004224 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 722911004225 gamma subunit interface [polypeptide binding]; other site 722911004226 epsilon subunit interface [polypeptide binding]; other site 722911004227 LBP interface [polypeptide binding]; other site 722911004228 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 722911004229 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 722911004230 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 722911004231 alpha subunit interaction interface [polypeptide binding]; other site 722911004232 Walker A motif; other site 722911004233 ATP binding site [chemical binding]; other site 722911004234 Walker B motif; other site 722911004235 inhibitor binding site; inhibition site 722911004236 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 722911004237 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 722911004238 core domain interface [polypeptide binding]; other site 722911004239 delta subunit interface [polypeptide binding]; other site 722911004240 epsilon subunit interface [polypeptide binding]; other site 722911004241 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 722911004242 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 722911004243 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 722911004244 beta subunit interaction interface [polypeptide binding]; other site 722911004245 Walker A motif; other site 722911004246 ATP binding site [chemical binding]; other site 722911004247 Walker B motif; other site 722911004248 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 722911004249 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 722911004250 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 722911004251 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 722911004252 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 722911004253 ATP synthase subunit C; Region: ATP-synt_C; cl00466 722911004254 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 722911004255 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 722911004256 homoserine O-succinyltransferase; Provisional; Region: PRK05368 722911004257 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 722911004258 proposed active site lysine [active] 722911004259 conserved cys residue [active] 722911004260 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 722911004261 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 722911004262 active site 722911004263 DNA binding site [nucleotide binding] 722911004264 Int/Topo IB signature motif; other site 722911004265 Protein of unknown function (DUF497); Region: DUF497; pfam04365 722911004266 LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417 722911004267 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 722911004268 active site 722911004269 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; pfam08230 722911004270 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 722911004271 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 722911004272 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 722911004273 putative active site [active] 722911004274 putative NTP binding site [chemical binding]; other site 722911004275 putative nucleic acid binding site [nucleotide binding]; other site 722911004276 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 722911004277 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 722911004278 tape measure domain; Region: tape_meas_nterm; TIGR02675 722911004279 membrane protein P6; Region: PHA01399 722911004280 Phage-related protein [Function unknown]; Region: COG5412 722911004281 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 722911004282 Phage capsid family; Region: Phage_capsid; pfam05065 722911004283 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 722911004284 Phage terminase large subunit; Region: Terminase_3; cl12054 722911004285 Transcription factor WhiB; Region: Whib; pfam02467 722911004286 Repressor of nif and glnA expression [Transcription]; Region: COG1693 722911004287 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 722911004288 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 722911004289 catalytic site [active] 722911004290 putative active site [active] 722911004291 putative substrate binding site [chemical binding]; other site 722911004292 dimer interface [polypeptide binding]; other site 722911004293 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 722911004294 SPFH domain / Band 7 family; Region: Band_7; pfam01145 722911004295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 722911004296 salt bridge; other site 722911004297 non-specific DNA binding site [nucleotide binding]; other site 722911004298 sequence-specific DNA binding site [nucleotide binding]; other site 722911004299 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 722911004300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 722911004301 non-specific DNA binding site [nucleotide binding]; other site 722911004302 salt bridge; other site 722911004303 sequence-specific DNA binding site [nucleotide binding]; other site 722911004304 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 722911004305 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 722911004306 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 722911004307 active site 722911004308 homodimer interface [polypeptide binding]; other site 722911004309 catalytic site [active] 722911004310 acceptor binding site [chemical binding]; other site 722911004311 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 722911004312 dimer interface [polypeptide binding]; other site 722911004313 substrate binding site [chemical binding]; other site 722911004314 metal binding sites [ion binding]; metal-binding site 722911004315 Predicted membrane protein [Function unknown]; Region: COG1971 722911004316 Domain of unknown function DUF; Region: DUF204; pfam02659 722911004317 Domain of unknown function DUF; Region: DUF204; pfam02659 722911004318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 722911004319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 722911004320 DNA binding site [nucleotide binding] 722911004321 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 722911004322 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 722911004323 minor groove reading motif; other site 722911004324 helix-hairpin-helix signature motif; other site 722911004325 substrate binding pocket [chemical binding]; other site 722911004326 active site 722911004327 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 722911004328 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 722911004329 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 722911004330 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 722911004331 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 722911004332 active site 722911004333 HIGH motif; other site 722911004334 nucleotide binding site [chemical binding]; other site 722911004335 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 722911004336 active site 722911004337 KMSKS motif; other site 722911004338 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 722911004339 tRNA binding surface [nucleotide binding]; other site 722911004340 anticodon binding site; other site 722911004341 monofunctional chorismate mutase, alpha proteobacterial type; Region: CM_mono_cladeE; TIGR01795 722911004342 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 722911004343 transcription termination factor Rho; Provisional; Region: PRK12608 722911004344 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 722911004345 RNA binding site [nucleotide binding]; other site 722911004346 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 722911004347 multimer interface [polypeptide binding]; other site 722911004348 Walker A motif; other site 722911004349 ATP binding site [chemical binding]; other site 722911004350 Walker B motif; other site 722911004351 hypothetical protein; Provisional; Region: PRK07208 722911004352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 722911004353 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 722911004354 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 722911004355 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 722911004356 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 722911004357 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 722911004358 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 722911004359 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 722911004360 GatB domain; Region: GatB_Yqey; pfam02637 722911004361 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 722911004362 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 722911004363 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 722911004364 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 722911004365 RmuC family; Region: RmuC; pfam02646 722911004366 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 722911004367 putative homodimer interface [polypeptide binding]; other site 722911004368 putative homotetramer interface [polypeptide binding]; other site 722911004369 putative allosteric switch controlling residues; other site 722911004370 putative metal binding site [ion binding]; other site 722911004371 putative homodimer-homodimer interface [polypeptide binding]; other site 722911004372 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 722911004373 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 722911004374 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 722911004375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911004376 active site 722911004377 motif I; other site 722911004378 motif II; other site 722911004379 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 722911004380 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 722911004381 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 722911004382 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 722911004383 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 722911004384 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 722911004385 dimerization domain swap beta strand [polypeptide binding]; other site 722911004386 regulatory protein interface [polypeptide binding]; other site 722911004387 active site 722911004388 regulatory phosphorylation site [posttranslational modification]; other site 722911004389 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 722911004390 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 722911004391 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 722911004392 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 722911004393 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 722911004394 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 722911004395 dimer interface [polypeptide binding]; other site 722911004396 ssDNA binding site [nucleotide binding]; other site 722911004397 tetramer (dimer of dimers) interface [polypeptide binding]; other site 722911004398 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 722911004399 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 722911004400 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 722911004401 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 722911004402 active site 722911004403 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 722911004404 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 722911004405 catalytic residue [active] 722911004406 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 722911004407 substrate binding site [chemical binding]; other site 722911004408 active site 722911004409 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 722911004410 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 722911004411 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 722911004412 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 722911004413 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 722911004414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 722911004415 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 722911004416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911004417 dimer interface [polypeptide binding]; other site 722911004418 conserved gate region; other site 722911004419 putative PBP binding loops; other site 722911004420 ABC-ATPase subunit interface; other site 722911004421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911004422 dimer interface [polypeptide binding]; other site 722911004423 conserved gate region; other site 722911004424 putative PBP binding loops; other site 722911004425 ABC-ATPase subunit interface; other site 722911004426 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911004427 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 722911004428 Uncharacterized conserved protein [Function unknown]; Region: COG3937 722911004429 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 722911004430 catalytic triad [active] 722911004431 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 722911004432 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 722911004433 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 722911004434 replicative DNA helicase; Region: DnaB; TIGR00665 722911004435 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 722911004436 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 722911004437 Walker A motif; other site 722911004438 ATP binding site [chemical binding]; other site 722911004439 Walker B motif; other site 722911004440 DNA binding loops [nucleotide binding] 722911004441 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 722911004442 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 722911004443 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 722911004444 metal binding triad; other site 722911004445 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 722911004446 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 722911004447 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 722911004448 Nitrogen regulatory protein P-II; Region: P-II; smart00938 722911004449 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 722911004450 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 722911004451 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 722911004452 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 722911004453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 722911004454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 722911004455 putative glycosyl transferase; Provisional; Region: PRK10073 722911004456 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 722911004457 active site 722911004458 Peptidase family C69; Region: Peptidase_C69; pfam03577 722911004459 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 722911004460 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 722911004461 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 722911004462 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 722911004463 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 722911004464 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 722911004465 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 722911004466 putative active site [active] 722911004467 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 722911004468 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 722911004469 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 722911004470 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 722911004471 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 722911004472 Predicted membrane protein [Function unknown]; Region: COG1511 722911004473 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 722911004474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 722911004475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 722911004476 FMN-binding domain; Region: FMN_bind; cl01081 722911004477 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 722911004478 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 722911004479 Walker A/P-loop; other site 722911004480 ATP binding site [chemical binding]; other site 722911004481 Q-loop/lid; other site 722911004482 ABC transporter signature motif; other site 722911004483 Walker B; other site 722911004484 D-loop; other site 722911004485 H-loop/switch region; other site 722911004486 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 722911004487 FtsX-like permease family; Region: FtsX; pfam02687 722911004488 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 722911004489 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 722911004490 FtsX-like permease family; Region: FtsX; pfam02687 722911004491 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 722911004492 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 722911004493 Fe2+ transport protein; Region: Iron_transport; pfam10634 722911004494 Iron permease FTR1 family; Region: FTR1; cl00475 722911004495 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 722911004496 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 722911004497 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 722911004498 HIGH motif; other site 722911004499 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 722911004500 active site 722911004501 KMSKS motif; other site 722911004502 Protein of unknown function (DUF805); Region: DUF805; pfam05656 722911004503 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 722911004504 catalytic core [active] 722911004505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 722911004506 Predicted membrane protein [Function unknown]; Region: COG2246 722911004507 GtrA-like protein; Region: GtrA; pfam04138 722911004508 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 722911004509 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 722911004510 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 722911004511 Peptidase family C69; Region: Peptidase_C69; pfam03577 722911004512 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 722911004513 substrate binding site [chemical binding]; other site 722911004514 DNA polymerase III subunit delta'; Validated; Region: PRK07940 722911004515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911004516 Walker A motif; other site 722911004517 ATP binding site [chemical binding]; other site 722911004518 Walker B motif; other site 722911004519 thymidylate kinase; Validated; Region: tmk; PRK00698 722911004520 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 722911004521 TMP-binding site; other site 722911004522 ATP-binding site [chemical binding]; other site 722911004523 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 722911004524 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 722911004525 active site 722911004526 interdomain interaction site; other site 722911004527 putative metal-binding site [ion binding]; other site 722911004528 nucleotide binding site [chemical binding]; other site 722911004529 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 722911004530 domain I; other site 722911004531 phosphate binding site [ion binding]; other site 722911004532 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 722911004533 domain II; other site 722911004534 domain III; other site 722911004535 nucleotide binding site [chemical binding]; other site 722911004536 DNA binding groove [nucleotide binding] 722911004537 catalytic site [active] 722911004538 domain IV; other site 722911004539 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 722911004540 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 722911004541 active site 722911004542 2-isopropylmalate synthase; Validated; Region: PRK03739 722911004543 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 722911004544 active site 722911004545 catalytic residues [active] 722911004546 metal binding site [ion binding]; metal-binding site 722911004547 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 722911004548 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 722911004549 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 722911004550 metal binding site [ion binding]; metal-binding site 722911004551 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 722911004552 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 722911004553 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 722911004554 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 722911004555 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 722911004556 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 722911004557 putative allosteric regulatory site; other site 722911004558 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 722911004559 AAA domain; Region: AAA_14; pfam13173 722911004560 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 722911004561 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 722911004562 active site 722911004563 catalytic site [active] 722911004564 recombination protein RecR; Reviewed; Region: recR; PRK00076 722911004565 RecR protein; Region: RecR; pfam02132 722911004566 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 722911004567 putative active site [active] 722911004568 putative metal-binding site [ion binding]; other site 722911004569 tetramer interface [polypeptide binding]; other site 722911004570 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 722911004571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911004572 Walker A motif; other site 722911004573 ATP binding site [chemical binding]; other site 722911004574 Walker B motif; other site 722911004575 arginine finger; other site 722911004576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 722911004577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 722911004578 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 722911004579 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 722911004580 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 722911004581 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 722911004582 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 722911004583 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 722911004584 ATP binding site [chemical binding]; other site 722911004585 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 722911004586 Walker B motif; other site 722911004587 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 722911004588 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 722911004589 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 722911004590 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 722911004591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 722911004592 motif II; other site 722911004593 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 722911004594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 722911004595 NAD(P) binding site [chemical binding]; other site 722911004596 active site 722911004597 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 722911004598 xanthine permease; Region: pbuX; TIGR03173 722911004599 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 722911004600 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 722911004601 DNA binding residues [nucleotide binding] 722911004602 putative dimer interface [polypeptide binding]; other site 722911004603 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 722911004604 HSP70 interaction site [polypeptide binding]; other site 722911004605 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 722911004606 substrate binding site [polypeptide binding]; other site 722911004607 dimer interface [polypeptide binding]; other site 722911004608 GrpE; Region: GrpE; pfam01025 722911004609 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 722911004610 dimer interface [polypeptide binding]; other site 722911004611 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 722911004612 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 722911004613 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 722911004614 nucleotide binding site [chemical binding]; other site 722911004615 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 722911004616 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 722911004617 putative active site [active] 722911004618 putative catalytic site [active] 722911004619 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 722911004620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911004621 ABC-ATPase subunit interface; other site 722911004622 putative PBP binding loops; other site 722911004623 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911004624 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911004625 DNA binding site [nucleotide binding] 722911004626 domain linker motif; other site 722911004627 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911004628 ligand binding site [chemical binding]; other site 722911004629 dimerization interface [polypeptide binding]; other site 722911004630 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 722911004631 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 722911004632 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 722911004633 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911004634 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911004635 DNA binding site [nucleotide binding] 722911004636 domain linker motif; other site 722911004637 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911004638 ligand binding site [chemical binding]; other site 722911004639 dimerization interface [polypeptide binding]; other site 722911004640 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 722911004641 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 722911004642 active site 722911004643 catalytic site [active] 722911004644 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 722911004645 ketol-acid reductoisomerase; Provisional; Region: PRK05479 722911004646 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 722911004647 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 722911004648 ketol-acid reductoisomerase; Provisional; Region: PRK05479 722911004649 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 722911004650 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 722911004651 Putative amidase domain; Region: Amidase_6; pfam12671 722911004652 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911004653 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911004654 DNA binding site [nucleotide binding] 722911004655 domain linker motif; other site 722911004656 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 722911004657 dimerization interface [polypeptide binding]; other site 722911004658 ligand binding site [chemical binding]; other site 722911004659 sodium binding site [ion binding]; other site 722911004660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 722911004661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911004662 sucrose phosphorylase; Provisional; Region: PRK13840 722911004663 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 722911004664 active site 722911004665 homodimer interface [polypeptide binding]; other site 722911004666 catalytic site [active] 722911004667 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 722911004668 Transposase, Mutator family; Region: Transposase_mut; pfam00872 722911004669 MULE transposase domain; Region: MULE; pfam10551 722911004670 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911004671 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911004672 ligand binding site [chemical binding]; other site 722911004673 dimerization interface [polypeptide binding]; other site 722911004674 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 722911004675 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911004676 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 722911004677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911004678 dimer interface [polypeptide binding]; other site 722911004679 conserved gate region; other site 722911004680 putative PBP binding loops; other site 722911004681 ABC-ATPase subunit interface; other site 722911004682 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 722911004683 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 722911004684 putative active site [active] 722911004685 putative catalytic site [active] 722911004686 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 722911004687 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 722911004688 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911004689 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911004690 DNA binding site [nucleotide binding] 722911004691 domain linker motif; other site 722911004692 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 722911004693 dimerization interface [polypeptide binding]; other site 722911004694 ligand binding site [chemical binding]; other site 722911004695 sodium binding site [ion binding]; other site 722911004696 CrcB-like protein; Region: CRCB; pfam02537 722911004697 CrcB-like protein; Region: CRCB; pfam02537 722911004698 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 722911004699 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 722911004700 GDP-binding site [chemical binding]; other site 722911004701 ACT binding site; other site 722911004702 IMP binding site; other site 722911004703 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 722911004704 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 722911004705 active site 722911004706 intersubunit interface [polypeptide binding]; other site 722911004707 zinc binding site [ion binding]; other site 722911004708 Na+ binding site [ion binding]; other site 722911004709 heat shock protein HtpX; Provisional; Region: PRK03072 722911004710 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 722911004711 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 722911004712 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 722911004713 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 722911004714 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 722911004715 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 722911004716 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 722911004717 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911004718 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911004719 DNA binding site [nucleotide binding] 722911004720 domain linker motif; other site 722911004721 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911004722 dimerization interface [polypeptide binding]; other site 722911004723 ligand binding site [chemical binding]; other site 722911004724 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 722911004725 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 722911004726 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 722911004727 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 722911004728 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 722911004729 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 722911004730 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 722911004731 Haemolysin-III related; Region: HlyIII; pfam03006 722911004732 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 722911004733 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 722911004734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 722911004735 Coenzyme A binding pocket [chemical binding]; other site 722911004736 hypothetical protein; Provisional; Region: PRK01119 722911004737 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 722911004738 active site 722911004739 8-oxo-dGMP binding site [chemical binding]; other site 722911004740 nudix motif; other site 722911004741 metal binding site [ion binding]; metal-binding site 722911004742 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 722911004743 PLD-like domain; Region: PLDc_2; pfam13091 722911004744 putative homodimer interface [polypeptide binding]; other site 722911004745 putative active site [active] 722911004746 catalytic site [active] 722911004747 DEAD-like helicases superfamily; Region: DEXDc; smart00487 722911004748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 722911004749 ATP binding site [chemical binding]; other site 722911004750 putative Mg++ binding site [ion binding]; other site 722911004751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 722911004752 nucleotide binding region [chemical binding]; other site 722911004753 ATP-binding site [chemical binding]; other site 722911004754 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 722911004755 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 722911004756 methionine sulfoxide reductase B; Provisional; Region: PRK00222 722911004757 SelR domain; Region: SelR; pfam01641 722911004758 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 722911004759 Putative esterase; Region: Esterase; pfam00756 722911004760 aromatic amino acid exporter; Provisional; Region: PRK11689 722911004761 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 722911004762 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 722911004763 putative dimer interface [polypeptide binding]; other site 722911004764 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 722911004765 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 722911004766 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 722911004767 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 722911004768 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 722911004769 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 722911004770 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 722911004771 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 722911004772 phosphopeptide binding site; other site 722911004773 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 722911004774 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 722911004775 phosphopeptide binding site; other site 722911004776 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 722911004777 active site 722911004778 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 722911004779 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 722911004780 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 722911004781 Catalytic domain of Protein Kinases; Region: PKc; cd00180 722911004782 active site 722911004783 ATP binding site [chemical binding]; other site 722911004784 substrate binding site [chemical binding]; other site 722911004785 activation loop (A-loop); other site 722911004786 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 722911004787 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 722911004788 active site 722911004789 ATP binding site [chemical binding]; other site 722911004790 substrate binding site [chemical binding]; other site 722911004791 activation loop (A-loop); other site 722911004792 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 722911004793 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 722911004794 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 722911004795 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 722911004796 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 722911004797 Glutamine amidotransferase class-I; Region: GATase; pfam00117 722911004798 glutamine binding [chemical binding]; other site 722911004799 catalytic triad [active] 722911004800 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 722911004801 active site 722911004802 catalytic site [active] 722911004803 putative septation inhibitor protein; Reviewed; Region: PRK02251 722911004804 Rhomboid family; Region: Rhomboid; pfam01694 722911004805 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 722911004806 homodimer interface [polypeptide binding]; other site 722911004807 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 722911004808 active site pocket [active] 722911004809 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 722911004810 active site 722911004811 HIGH motif; other site 722911004812 dimer interface [polypeptide binding]; other site 722911004813 KMSKS motif; other site 722911004814 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 722911004815 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 722911004816 active site 722911004817 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 722911004818 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 722911004819 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 722911004820 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 722911004821 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 722911004822 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 722911004823 active site 722911004824 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 722911004825 Divergent AAA domain; Region: AAA_4; pfam04326 722911004826 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 722911004827 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 722911004828 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911004829 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911004830 DNA binding site [nucleotide binding] 722911004831 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911004832 dimerization interface [polypeptide binding]; other site 722911004833 ligand binding site [chemical binding]; other site 722911004834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 722911004835 Major Facilitator Superfamily; Region: MFS_1; pfam07690 722911004836 putative substrate translocation pore; other site 722911004837 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 722911004838 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 722911004839 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 722911004840 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 722911004841 catalytic residue [active] 722911004842 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 722911004843 catalytic residues [active] 722911004844 peroxiredoxin; Region: AhpC; TIGR03137 722911004845 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 722911004846 dimer interface [polypeptide binding]; other site 722911004847 decamer (pentamer of dimers) interface [polypeptide binding]; other site 722911004848 catalytic triad [active] 722911004849 peroxidatic and resolving cysteines [active] 722911004850 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 722911004851 active site clefts [active] 722911004852 zinc binding site [ion binding]; other site 722911004853 dimer interface [polypeptide binding]; other site 722911004854 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 722911004855 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 722911004856 Domain of unknown function DUF21; Region: DUF21; pfam01595 722911004857 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 722911004858 Transporter associated domain; Region: CorC_HlyC; smart01091 722911004859 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 722911004860 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 722911004861 dimerization interface [polypeptide binding]; other site 722911004862 DPS ferroxidase diiron center [ion binding]; other site 722911004863 ion pore; other site 722911004864 AAA domain; Region: AAA_14; pfam13173 722911004865 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 722911004866 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 722911004867 Protein of unknown function DUF45; Region: DUF45; pfam01863 722911004868 hypothetical protein; Provisional; Region: PRK06062 722911004869 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 722911004870 inhibitor-cofactor binding pocket; inhibition site 722911004871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911004872 catalytic residue [active] 722911004873 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 722911004874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 722911004875 DNA-binding site [nucleotide binding]; DNA binding site 722911004876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 722911004877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911004878 homodimer interface [polypeptide binding]; other site 722911004879 catalytic residue [active] 722911004880 Transposase; Region: DDE_Tnp_ISL3; pfam01610 722911004881 aspartate aminotransferase; Provisional; Region: PRK05764 722911004882 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 722911004883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911004884 homodimer interface [polypeptide binding]; other site 722911004885 catalytic residue [active] 722911004886 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 722911004887 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 722911004888 putative DNA binding site [nucleotide binding]; other site 722911004889 putative Zn2+ binding site [ion binding]; other site 722911004890 AsnC family; Region: AsnC_trans_reg; pfam01037 722911004891 glutamate dehydrogenase; Provisional; Region: PRK09414 722911004892 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 722911004893 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 722911004894 NAD(P) binding site [chemical binding]; other site 722911004895 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 722911004896 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 722911004897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 722911004898 Mg2+ binding site [ion binding]; other site 722911004899 G-X-G motif; other site 722911004900 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 722911004901 anchoring element; other site 722911004902 dimer interface [polypeptide binding]; other site 722911004903 ATP binding site [chemical binding]; other site 722911004904 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 722911004905 active site 722911004906 putative metal-binding site [ion binding]; other site 722911004907 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 722911004908 Protein of unknown function (DUF721); Region: DUF721; pfam05258 722911004909 recombination protein F; Reviewed; Region: recF; PRK00064 722911004910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911004911 Walker A/P-loop; other site 722911004912 ATP binding site [chemical binding]; other site 722911004913 Q-loop/lid; other site 722911004914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 722911004915 ABC transporter signature motif; other site 722911004916 Walker B; other site 722911004917 D-loop; other site 722911004918 H-loop/switch region; other site 722911004919 DNA polymerase III subunit beta; Validated; Region: PRK07761 722911004920 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 722911004921 putative DNA binding surface [nucleotide binding]; other site 722911004922 dimer interface [polypeptide binding]; other site 722911004923 beta-clamp/clamp loader binding surface; other site 722911004924 beta-clamp/translesion DNA polymerase binding surface; other site 722911004925 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 722911004926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 722911004927 Walker A motif; other site 722911004928 ATP binding site [chemical binding]; other site 722911004929 Walker B motif; other site 722911004930 arginine finger; other site 722911004931 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 722911004932 DnaA box-binding interface [nucleotide binding]; other site 722911004933 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 722911004934 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 722911004935 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 722911004936 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 722911004937 G-X-X-G motif; other site 722911004938 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 722911004939 RxxxH motif; other site 722911004940 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 722911004941 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 722911004942 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 722911004943 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 722911004944 P-loop; other site 722911004945 Magnesium ion binding site [ion binding]; other site 722911004946 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 722911004947 Magnesium ion binding site [ion binding]; other site 722911004948 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 722911004949 ParB-like nuclease domain; Region: ParBc; pfam02195 722911004950 Transposase, Mutator family; Region: Transposase_mut; pfam00872 722911004951 MULE transposase domain; Region: MULE; pfam10551 722911004952 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911004953 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 722911004954 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911004955 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 722911004956 DNA binding site [nucleotide binding] 722911004957 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911004958 ligand binding site [chemical binding]; other site 722911004959 dimerization interface [polypeptide binding]; other site 722911004960 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 722911004961 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 722911004962 Ca binding site [ion binding]; other site 722911004963 active site 722911004964 catalytic site [active] 722911004965 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 722911004966 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 722911004967 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 722911004968 integral membrane protein MviN; Region: mviN; TIGR01695 722911004969 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 722911004970 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 722911004971 active site 722911004972 Ap6A binding site [chemical binding]; other site 722911004973 nudix motif; other site 722911004974 metal binding site [ion binding]; metal-binding site 722911004975 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 722911004976 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 722911004977 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 722911004978 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 722911004979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 722911004980 Domain of unknown function (DUF348); Region: DUF348; pfam03990 722911004981 G5 domain; Region: G5; pfam07501 722911004982 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 722911004983 N-acetyl-D-glucosamine binding site [chemical binding]; other site 722911004984 catalytic residue [active] 722911004985 Gamma interferon inducible lysosomal thiol reductase (GILT); Region: GILT; pfam03227 722911004986 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 722911004987 Catalytic domain of Protein Kinases; Region: PKc; cd00180 722911004988 active site 722911004989 ATP binding site [chemical binding]; other site 722911004990 substrate binding site [chemical binding]; other site 722911004991 activation loop (A-loop); other site 722911004992 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 722911004993 AAA ATPase domain; Region: AAA_16; pfam13191 722911004994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 722911004995 non-specific DNA binding site [nucleotide binding]; other site 722911004996 salt bridge; other site 722911004997 sequence-specific DNA binding site [nucleotide binding]; other site 722911004998 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 722911004999 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 722911005000 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 722911005001 GtrA-like protein; Region: GtrA; pfam04138 722911005002 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 722911005003 catalytic residues [active] 722911005004 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 722911005005 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 722911005006 Class I ribonucleotide reductase; Region: RNR_I; cd01679 722911005007 active site 722911005008 dimer interface [polypeptide binding]; other site 722911005009 catalytic residues [active] 722911005010 effector binding site; other site 722911005011 R2 peptide binding site; other site 722911005012 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 722911005013 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 722911005014 dimer interface [polypeptide binding]; other site 722911005015 putative radical transfer pathway; other site 722911005016 diiron center [ion binding]; other site 722911005017 tyrosyl radical; other site 722911005018 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 722911005019 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 722911005020 active site 722911005021 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 722911005022 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 722911005023 Walker A/P-loop; other site 722911005024 ATP binding site [chemical binding]; other site 722911005025 Q-loop/lid; other site 722911005026 ABC transporter signature motif; other site 722911005027 Walker B; other site 722911005028 D-loop; other site 722911005029 H-loop/switch region; other site 722911005030 TOBE domain; Region: TOBE_2; pfam08402 722911005031 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 722911005032 Cna protein B-type domain; Region: Cna_B; pfam05738 722911005033 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 722911005034 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 722911005035 active site 722911005036 catalytic site [active] 722911005037 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 722911005038 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 722911005039 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 722911005040 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 722911005041 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 722911005042 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 722911005043 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 722911005044 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 722911005045 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 722911005046 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 722911005047 Soluble P-type ATPase [General function prediction only]; Region: COG4087 722911005048 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 722911005049 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 722911005050 trimer interface [polypeptide binding]; other site 722911005051 active site 722911005052 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 722911005053 Serine hydrolase (FSH1); Region: FSH1; pfam03959 722911005054 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 722911005055 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 722911005056 nucleoside/Zn binding site; other site 722911005057 dimer interface [polypeptide binding]; other site 722911005058 catalytic motif [active] 722911005059 Melibiase; Region: Melibiase; pfam02065 722911005060 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 722911005061 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 722911005062 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911005063 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 722911005064 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 722911005065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911005066 dimer interface [polypeptide binding]; other site 722911005067 conserved gate region; other site 722911005068 putative PBP binding loops; other site 722911005069 ABC-ATPase subunit interface; other site 722911005070 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 722911005071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911005072 dimer interface [polypeptide binding]; other site 722911005073 conserved gate region; other site 722911005074 putative PBP binding loops; other site 722911005075 ABC-ATPase subunit interface; other site 722911005076 Transcriptional regulators [Transcription]; Region: PurR; COG1609 722911005077 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 722911005078 ligand binding site [chemical binding]; other site 722911005079 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 722911005080 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 722911005081 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 722911005082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 722911005083 dimer interface [polypeptide binding]; other site 722911005084 conserved gate region; other site 722911005085 putative PBP binding loops; other site 722911005086 ABC-ATPase subunit interface; other site 722911005087 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 722911005088 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 722911005089 active site 722911005090 catalytic site [active] 722911005091 probable galactinol--sucrose galactosyltransferase 1; Region: PLN02355 722911005092 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 722911005093 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 722911005094 Ca binding site [ion binding]; other site 722911005095 active site 722911005096 catalytic site [active] 722911005097 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 722911005098 tetramer interface [polypeptide binding]; other site 722911005099 threonine dehydratase; Provisional; Region: PRK08198 722911005100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 722911005101 catalytic residue [active] 722911005102 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 722911005103 NAD-dependent deacetylase; Provisional; Region: PRK00481 722911005104 SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent...; Region: SIRT7; cd01410 722911005105 NAD+ binding site [chemical binding]; other site 722911005106 substrate binding site [chemical binding]; other site 722911005107 Zn binding site [ion binding]; other site