-- dump date 20140619_002941 -- class Genbank::misc_feature -- table misc_feature_note -- id note 759350000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 759350000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350000003 Walker A motif; other site 759350000004 ATP binding site [chemical binding]; other site 759350000005 Walker B motif; other site 759350000006 arginine finger; other site 759350000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 759350000008 DnaA box-binding interface [nucleotide binding]; other site 759350000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 759350000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 759350000011 putative DNA binding surface [nucleotide binding]; other site 759350000012 dimer interface [polypeptide binding]; other site 759350000013 beta-clamp/clamp loader binding surface; other site 759350000014 beta-clamp/translesion DNA polymerase binding surface; other site 759350000015 recombination protein F; Reviewed; Region: recF; PRK00064 759350000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350000017 Walker A/P-loop; other site 759350000018 ATP binding site [chemical binding]; other site 759350000019 Q-loop/lid; other site 759350000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350000021 ABC transporter signature motif; other site 759350000022 Walker B; other site 759350000023 D-loop; other site 759350000024 H-loop/switch region; other site 759350000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 759350000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 759350000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759350000028 Mg2+ binding site [ion binding]; other site 759350000029 G-X-G motif; other site 759350000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 759350000031 anchoring element; other site 759350000032 dimer interface [polypeptide binding]; other site 759350000033 ATP binding site [chemical binding]; other site 759350000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 759350000035 active site 759350000036 putative metal-binding site [ion binding]; other site 759350000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 759350000038 DNA gyrase subunit A; Validated; Region: PRK05560 759350000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 759350000040 CAP-like domain; other site 759350000041 active site 759350000042 primary dimer interface [polypeptide binding]; other site 759350000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759350000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759350000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759350000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759350000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759350000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759350000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 759350000050 Archaeal ATPase; Region: Arch_ATPase; pfam01637 759350000051 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 759350000052 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 759350000053 glutamate dehydrogenase; Provisional; Region: PRK09414 759350000054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 759350000055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 759350000056 NAD(P) binding site [chemical binding]; other site 759350000057 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 759350000058 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 759350000059 putative DNA binding site [nucleotide binding]; other site 759350000060 putative Zn2+ binding site [ion binding]; other site 759350000061 AsnC family; Region: AsnC_trans_reg; pfam01037 759350000062 aspartate aminotransferase; Provisional; Region: PRK05764 759350000063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759350000064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350000065 homodimer interface [polypeptide binding]; other site 759350000066 catalytic residue [active] 759350000067 Double zinc ribbon; Region: DZR; pfam12773 759350000068 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 759350000069 Protein of unknown function DUF45; Region: DUF45; pfam01863 759350000070 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 759350000071 AAA domain; Region: AAA_14; pfam13173 759350000072 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 759350000073 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 759350000074 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 759350000075 dimerization interface [polypeptide binding]; other site 759350000076 DPS ferroxidase diiron center [ion binding]; other site 759350000077 ion pore; other site 759350000078 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 759350000079 Domain of unknown function DUF21; Region: DUF21; pfam01595 759350000080 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 759350000081 Transporter associated domain; Region: CorC_HlyC; smart01091 759350000082 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 759350000083 phosphopeptide binding site; other site 759350000084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 759350000085 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 759350000086 phosphopeptide binding site; other site 759350000087 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 759350000088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350000089 Walker A/P-loop; other site 759350000090 ATP binding site [chemical binding]; other site 759350000091 Q-loop/lid; other site 759350000092 ABC transporter signature motif; other site 759350000093 Walker B; other site 759350000094 D-loop; other site 759350000095 H-loop/switch region; other site 759350000096 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 759350000097 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 759350000098 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 759350000099 active site clefts [active] 759350000100 zinc binding site [ion binding]; other site 759350000101 dimer interface [polypeptide binding]; other site 759350000102 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 759350000103 peroxiredoxin; Region: AhpC; TIGR03137 759350000104 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 759350000105 dimer interface [polypeptide binding]; other site 759350000106 decamer (pentamer of dimers) interface [polypeptide binding]; other site 759350000107 catalytic triad [active] 759350000108 peroxidatic and resolving cysteines [active] 759350000109 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 759350000110 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759350000111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759350000112 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 759350000113 catalytic residue [active] 759350000114 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 759350000115 catalytic residues [active] 759350000116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350000117 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759350000118 putative substrate translocation pore; other site 759350000119 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350000120 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350000121 DNA binding site [nucleotide binding] 759350000122 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350000123 dimerization interface [polypeptide binding]; other site 759350000124 ligand binding site [chemical binding]; other site 759350000125 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 759350000126 Divergent AAA domain; Region: AAA_4; pfam04326 759350000127 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 759350000128 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 759350000129 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 759350000130 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 759350000131 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 759350000132 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 759350000133 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 759350000134 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 759350000135 Na binding site [ion binding]; other site 759350000136 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 759350000137 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 759350000138 active site 759350000139 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 759350000140 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 759350000141 active site 759350000142 HIGH motif; other site 759350000143 dimer interface [polypeptide binding]; other site 759350000144 KMSKS motif; other site 759350000145 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 759350000146 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759350000147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350000148 active site 759350000149 phosphorylation site [posttranslational modification] 759350000150 intermolecular recognition site; other site 759350000151 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 759350000152 DNA binding residues [nucleotide binding] 759350000153 dimerization interface [polypeptide binding]; other site 759350000154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 759350000155 H+ Antiporter protein; Region: 2A0121; TIGR00900 759350000156 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 759350000157 homodimer interface [polypeptide binding]; other site 759350000158 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 759350000159 active site pocket [active] 759350000160 Rhomboid family; Region: Rhomboid; pfam01694 759350000161 putative septation inhibitor protein; Reviewed; Region: PRK02251 759350000162 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 759350000163 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 759350000164 active site 759350000165 catalytic site [active] 759350000166 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 759350000167 Glutamine amidotransferase class-I; Region: GATase; pfam00117 759350000168 glutamine binding [chemical binding]; other site 759350000169 catalytic triad [active] 759350000170 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 759350000171 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 759350000172 active site 759350000173 ATP binding site [chemical binding]; other site 759350000174 substrate binding site [chemical binding]; other site 759350000175 activation loop (A-loop); other site 759350000176 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 759350000177 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 759350000178 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 759350000179 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 759350000180 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 759350000181 Catalytic domain of Protein Kinases; Region: PKc; cd00180 759350000182 active site 759350000183 ATP binding site [chemical binding]; other site 759350000184 substrate binding site [chemical binding]; other site 759350000185 activation loop (A-loop); other site 759350000186 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 759350000187 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 759350000188 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 759350000189 active site 759350000190 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 759350000191 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 759350000192 phosphopeptide binding site; other site 759350000193 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 759350000194 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 759350000195 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 759350000196 phosphopeptide binding site; other site 759350000197 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 759350000198 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 759350000199 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 759350000200 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 759350000201 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 759350000202 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 759350000203 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 759350000204 metal ion-dependent adhesion site (MIDAS); other site 759350000205 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 759350000206 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 759350000207 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 759350000208 putative dimer interface [polypeptide binding]; other site 759350000209 aromatic amino acid exporter; Provisional; Region: PRK11689 759350000210 Putative esterase; Region: Esterase; pfam00756 759350000211 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 759350000212 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 759350000213 methionine sulfoxide reductase B; Provisional; Region: PRK00222 759350000214 SelR domain; Region: SelR; pfam01641 759350000215 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 759350000216 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 759350000217 active site 759350000218 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 759350000219 PLD-like domain; Region: PLDc_2; pfam13091 759350000220 putative homodimer interface [polypeptide binding]; other site 759350000221 putative active site [active] 759350000222 catalytic site [active] 759350000223 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 759350000224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759350000225 ATP binding site [chemical binding]; other site 759350000226 putative Mg++ binding site [ion binding]; other site 759350000227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759350000228 nucleotide binding region [chemical binding]; other site 759350000229 ATP-binding site [chemical binding]; other site 759350000230 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 759350000231 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 759350000232 active site 759350000233 8-oxo-dGMP binding site [chemical binding]; other site 759350000234 nudix motif; other site 759350000235 metal binding site [ion binding]; metal-binding site 759350000236 hypothetical protein; Provisional; Region: PRK01119 759350000237 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 759350000238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759350000239 Coenzyme A binding pocket [chemical binding]; other site 759350000240 Haemolysin-III related; Region: HlyIII; pfam03006 759350000241 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 759350000242 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 759350000243 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 759350000244 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 759350000245 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 759350000246 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 759350000247 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 759350000248 Soluble P-type ATPase [General function prediction only]; Region: COG4087 759350000249 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 759350000250 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 759350000251 ferredoxin-NADP+ reductase; Region: PLN02852 759350000252 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759350000253 heat shock protein HtpX; Provisional; Region: PRK03072 759350000254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 759350000255 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 759350000256 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 759350000257 active site 759350000258 SUMO-1 interface [polypeptide binding]; other site 759350000259 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 759350000260 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 759350000261 active site 759350000262 intersubunit interface [polypeptide binding]; other site 759350000263 zinc binding site [ion binding]; other site 759350000264 Na+ binding site [ion binding]; other site 759350000265 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 759350000266 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 759350000267 GDP-binding site [chemical binding]; other site 759350000268 ACT binding site; other site 759350000269 IMP binding site; other site 759350000270 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 759350000271 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 759350000272 Cl- selectivity filter; other site 759350000273 Cl- binding residues [ion binding]; other site 759350000274 pore gating glutamate residue; other site 759350000275 dimer interface [polypeptide binding]; other site 759350000276 H+/Cl- coupling transport residue; other site 759350000277 TrkA-C domain; Region: TrkA_C; pfam02080 759350000278 CrcB-like protein; Region: CRCB; pfam02537 759350000279 CrcB-like protein; Region: CRCB; pfam02537 759350000280 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 759350000281 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759350000282 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 759350000283 TM-ABC transporter signature motif; other site 759350000284 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 759350000285 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 759350000286 TM-ABC transporter signature motif; other site 759350000287 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 759350000288 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 759350000289 Walker A/P-loop; other site 759350000290 ATP binding site [chemical binding]; other site 759350000291 Q-loop/lid; other site 759350000292 ABC transporter signature motif; other site 759350000293 Walker B; other site 759350000294 D-loop; other site 759350000295 H-loop/switch region; other site 759350000296 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 759350000297 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 759350000298 Walker A/P-loop; other site 759350000299 ATP binding site [chemical binding]; other site 759350000300 Q-loop/lid; other site 759350000301 ABC transporter signature motif; other site 759350000302 Walker B; other site 759350000303 D-loop; other site 759350000304 H-loop/switch region; other site 759350000305 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 759350000306 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 759350000307 ligand binding site [chemical binding]; other site 759350000308 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350000309 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350000310 DNA binding site [nucleotide binding] 759350000311 domain linker motif; other site 759350000312 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759350000313 sucrose phosphorylase; Provisional; Region: PRK13840 759350000314 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 759350000315 active site 759350000316 homodimer interface [polypeptide binding]; other site 759350000317 catalytic site [active] 759350000318 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 759350000319 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759350000320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350000321 metabolite-proton symporter; Region: 2A0106; TIGR00883 759350000322 putative substrate translocation pore; other site 759350000323 ketol-acid reductoisomerase; Provisional; Region: PRK05479 759350000324 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 759350000325 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 759350000326 ketol-acid reductoisomerase; Provisional; Region: PRK05479 759350000327 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 759350000328 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 759350000329 MarR family; Region: MarR_2; cl17246 759350000330 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 759350000331 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 759350000332 active site 759350000333 catalytic site [active] 759350000334 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 759350000335 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350000336 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350000337 DNA binding site [nucleotide binding] 759350000338 domain linker motif; other site 759350000339 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350000340 ligand binding site [chemical binding]; other site 759350000341 dimerization interface [polypeptide binding]; other site 759350000342 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 759350000343 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 759350000344 trehalose synthase; Region: treS_nterm; TIGR02456 759350000345 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 759350000346 active site 759350000347 catalytic site [active] 759350000348 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 759350000349 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350000350 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 759350000351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350000352 dimer interface [polypeptide binding]; other site 759350000353 conserved gate region; other site 759350000354 putative PBP binding loops; other site 759350000355 ABC-ATPase subunit interface; other site 759350000356 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350000357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350000358 dimer interface [polypeptide binding]; other site 759350000359 conserved gate region; other site 759350000360 putative PBP binding loops; other site 759350000361 ABC-ATPase subunit interface; other site 759350000362 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 759350000363 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 759350000364 Ca binding site [ion binding]; other site 759350000365 active site 759350000366 catalytic site [active] 759350000367 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 759350000368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759350000369 motif II; other site 759350000370 TraX protein; Region: TraX; cl05434 759350000371 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350000372 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350000373 DNA binding site [nucleotide binding] 759350000374 domain linker motif; other site 759350000375 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350000376 ligand binding site [chemical binding]; other site 759350000377 dimerization interface [polypeptide binding]; other site 759350000378 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 759350000379 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 759350000380 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 759350000381 alkaline phosphatase; Provisional; Region: PRK10518 759350000382 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 759350000383 dimer interface [polypeptide binding]; other site 759350000384 active site 759350000385 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 759350000386 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759350000387 nucleotide binding site [chemical binding]; other site 759350000388 GrpE; Region: GrpE; pfam01025 759350000389 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 759350000390 dimer interface [polypeptide binding]; other site 759350000391 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 759350000392 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 759350000393 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 759350000394 HSP70 interaction site [polypeptide binding]; other site 759350000395 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 759350000396 substrate binding site [polypeptide binding]; other site 759350000397 dimer interface [polypeptide binding]; other site 759350000398 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 759350000399 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 759350000400 DNA binding residues [nucleotide binding] 759350000401 putative dimer interface [polypeptide binding]; other site 759350000402 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 759350000403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759350000404 motif II; other site 759350000405 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 759350000406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350000407 dimer interface [polypeptide binding]; other site 759350000408 conserved gate region; other site 759350000409 putative PBP binding loops; other site 759350000410 ABC-ATPase subunit interface; other site 759350000411 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350000412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350000413 dimer interface [polypeptide binding]; other site 759350000414 conserved gate region; other site 759350000415 putative PBP binding loops; other site 759350000416 ABC-ATPase subunit interface; other site 759350000417 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 759350000418 active site 759350000419 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350000420 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350000421 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350000422 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350000423 DNA binding site [nucleotide binding] 759350000424 domain linker motif; other site 759350000425 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350000426 dimerization interface [polypeptide binding]; other site 759350000427 ligand binding site [chemical binding]; other site 759350000428 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 759350000429 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 759350000430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 759350000431 Helix-turn-helix domain; Region: HTH_28; pfam13518 759350000432 Winged helix-turn helix; Region: HTH_29; pfam13551 759350000433 putative transposase OrfB; Reviewed; Region: PHA02517 759350000434 HTH-like domain; Region: HTH_21; pfam13276 759350000435 Integrase core domain; Region: rve; pfam00665 759350000436 Integrase core domain; Region: rve_2; pfam13333 759350000437 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 759350000438 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 759350000439 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 759350000440 ATP binding site [chemical binding]; other site 759350000441 Walker B motif; other site 759350000442 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 759350000443 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 759350000444 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 759350000445 TadE-like protein; Region: TadE; pfam07811 759350000446 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 759350000447 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 759350000448 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 759350000449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759350000450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759350000451 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 759350000452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350000453 Walker A motif; other site 759350000454 ATP binding site [chemical binding]; other site 759350000455 Walker B motif; other site 759350000456 arginine finger; other site 759350000457 recombination protein RecR; Reviewed; Region: recR; PRK00076 759350000458 RecR protein; Region: RecR; pfam02132 759350000459 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 759350000460 putative active site [active] 759350000461 putative metal-binding site [ion binding]; other site 759350000462 tetramer interface [polypeptide binding]; other site 759350000463 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 759350000464 active site 759350000465 catalytic site [active] 759350000466 aspartate kinase; Reviewed; Region: PRK06635 759350000467 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 759350000468 putative nucleotide binding site [chemical binding]; other site 759350000469 putative catalytic residues [active] 759350000470 putative Mg ion binding site [ion binding]; other site 759350000471 putative aspartate binding site [chemical binding]; other site 759350000472 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 759350000473 putative allosteric regulatory site; other site 759350000474 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 759350000475 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 759350000476 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 759350000477 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 759350000478 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 759350000479 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 759350000480 metal binding site [ion binding]; metal-binding site 759350000481 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 759350000482 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 759350000483 2-isopropylmalate synthase; Validated; Region: PRK03739 759350000484 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 759350000485 active site 759350000486 catalytic residues [active] 759350000487 metal binding site [ion binding]; metal-binding site 759350000488 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 759350000489 Transglycosylase; Region: Transgly; pfam00912 759350000490 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 759350000491 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 759350000492 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 759350000493 active site 759350000494 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 759350000495 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 759350000496 active site 759350000497 interdomain interaction site; other site 759350000498 putative metal-binding site [ion binding]; other site 759350000499 nucleotide binding site [chemical binding]; other site 759350000500 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 759350000501 domain I; other site 759350000502 phosphate binding site [ion binding]; other site 759350000503 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 759350000504 domain II; other site 759350000505 domain III; other site 759350000506 nucleotide binding site [chemical binding]; other site 759350000507 DNA binding groove [nucleotide binding] 759350000508 catalytic site [active] 759350000509 domain IV; other site 759350000510 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 759350000511 thymidylate kinase; Validated; Region: tmk; PRK00698 759350000512 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 759350000513 TMP-binding site; other site 759350000514 ATP-binding site [chemical binding]; other site 759350000515 DNA polymerase III subunit delta'; Validated; Region: PRK07940 759350000516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350000517 Walker A motif; other site 759350000518 ATP binding site [chemical binding]; other site 759350000519 Walker B motif; other site 759350000520 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 759350000521 substrate binding site [chemical binding]; other site 759350000522 Peptidase family C69; Region: Peptidase_C69; pfam03577 759350000523 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 759350000524 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 759350000525 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 759350000526 Predicted membrane protein [Function unknown]; Region: COG2246 759350000527 GtrA-like protein; Region: GtrA; pfam04138 759350000528 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759350000529 catalytic core [active] 759350000530 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 759350000531 active site 759350000532 phosphate binding residues; other site 759350000533 catalytic residues [active] 759350000534 Protein of unknown function (DUF805); Region: DUF805; pfam05656 759350000535 Abi-like protein; Region: Abi_2; pfam07751 759350000536 Transposase, Mutator family; Region: Transposase_mut; pfam00872 759350000537 MULE transposase domain; Region: MULE; pfam10551 759350000538 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 759350000539 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 759350000540 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 759350000541 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 759350000542 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 759350000543 HsdM N-terminal domain; Region: HsdM_N; pfam12161 759350000544 Methyltransferase domain; Region: Methyltransf_26; pfam13659 759350000545 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 759350000546 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 759350000547 HIGH motif; other site 759350000548 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 759350000549 active site 759350000550 KMSKS motif; other site 759350000551 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 759350000552 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 759350000553 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 759350000554 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 759350000555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350000556 putative substrate translocation pore; other site 759350000557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350000558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759350000559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759350000560 WHG domain; Region: WHG; pfam13305 759350000561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759350000562 HNH endonuclease; Region: HNH_2; pfam13391 759350000563 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 759350000564 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 759350000565 cofactor binding site; other site 759350000566 DNA binding site [nucleotide binding] 759350000567 substrate interaction site [chemical binding]; other site 759350000568 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 759350000569 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 759350000570 AAA domain; Region: AAA_25; pfam13481 759350000571 AAA domain; Region: AAA_25; pfam13481 759350000572 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 759350000573 Walker A motif; other site 759350000574 ATP binding site [chemical binding]; other site 759350000575 Walker B motif; other site 759350000576 Helix-turn-helix domain; Region: HTH_17; cl17695 759350000577 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 759350000578 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759350000579 active site 759350000580 Int/Topo IB signature motif; other site 759350000581 DNA binding site [nucleotide binding] 759350000582 MgtE intracellular N domain; Region: MgtE_N; cl15244 759350000583 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 759350000584 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759350000585 active site 759350000586 Int/Topo IB signature motif; other site 759350000587 DNA binding site [nucleotide binding] 759350000588 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 759350000589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759350000590 non-specific DNA binding site [nucleotide binding]; other site 759350000591 salt bridge; other site 759350000592 sequence-specific DNA binding site [nucleotide binding]; other site 759350000593 Iron permease FTR1 family; Region: FTR1; cl00475 759350000594 Fe2+ transport protein; Region: Iron_transport; pfam10634 759350000595 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 759350000596 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759350000597 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 759350000598 FtsX-like permease family; Region: FtsX; pfam02687 759350000599 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 759350000600 FtsX-like permease family; Region: FtsX; pfam02687 759350000601 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350000602 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759350000603 Walker A/P-loop; other site 759350000604 ATP binding site [chemical binding]; other site 759350000605 Q-loop/lid; other site 759350000606 ABC transporter signature motif; other site 759350000607 Walker B; other site 759350000608 D-loop; other site 759350000609 H-loop/switch region; other site 759350000610 FMN-binding domain; Region: FMN_bind; cl01081 759350000611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759350000612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759350000613 Predicted membrane protein [Function unknown]; Region: COG1511 759350000614 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 759350000615 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 759350000616 Predicted membrane protein [Function unknown]; Region: COG1511 759350000617 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 759350000618 Predicted membrane protein [Function unknown]; Region: COG1511 759350000619 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 759350000620 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 759350000621 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 759350000622 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 759350000623 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 759350000624 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 759350000625 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 759350000626 putative active site [active] 759350000627 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 759350000628 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 759350000629 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 759350000630 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 759350000631 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 759350000632 Peptidase family C69; Region: Peptidase_C69; pfam03577 759350000633 putative glycosyl transferase; Provisional; Region: PRK10073 759350000634 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 759350000635 active site 759350000636 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759350000637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759350000638 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 759350000639 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 759350000640 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 759350000641 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 759350000642 P loop; other site 759350000643 GTP binding site [chemical binding]; other site 759350000644 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 759350000645 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 759350000646 Nitrogen regulatory protein P-II; Region: P-II; smart00938 759350000647 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 759350000648 metal binding triad; other site 759350000649 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 759350000650 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 759350000651 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 759350000652 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759350000653 replicative DNA helicase; Region: DnaB; TIGR00665 759350000654 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 759350000655 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 759350000656 Walker A motif; other site 759350000657 ATP binding site [chemical binding]; other site 759350000658 Walker B motif; other site 759350000659 DNA binding loops [nucleotide binding] 759350000660 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 759350000661 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759350000662 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 759350000663 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 759350000664 catalytic triad [active] 759350000665 Uncharacterized conserved protein [Function unknown]; Region: COG3937 759350000666 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 759350000667 ABC1 family; Region: ABC1; cl17513 759350000668 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 759350000669 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 759350000670 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759350000671 catalytic residue [active] 759350000672 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 759350000673 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 759350000674 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 759350000675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759350000676 active site 759350000677 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 759350000678 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 759350000679 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 759350000680 dimer interface [polypeptide binding]; other site 759350000681 ssDNA binding site [nucleotide binding]; other site 759350000682 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759350000683 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 759350000684 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 759350000685 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 759350000686 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 759350000687 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 759350000688 dimerization domain swap beta strand [polypeptide binding]; other site 759350000689 regulatory protein interface [polypeptide binding]; other site 759350000690 active site 759350000691 regulatory phosphorylation site [posttranslational modification]; other site 759350000692 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 759350000693 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 759350000694 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 759350000695 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 759350000696 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 759350000697 amphipathic channel; other site 759350000698 Asn-Pro-Ala signature motifs; other site 759350000699 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 759350000700 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 759350000701 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 759350000702 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759350000703 active site 759350000704 motif I; other site 759350000705 motif II; other site 759350000706 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 759350000707 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 759350000708 putative homodimer interface [polypeptide binding]; other site 759350000709 putative homotetramer interface [polypeptide binding]; other site 759350000710 putative allosteric switch controlling residues; other site 759350000711 putative metal binding site [ion binding]; other site 759350000712 putative homodimer-homodimer interface [polypeptide binding]; other site 759350000713 RmuC family; Region: RmuC; pfam02646 759350000714 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 759350000715 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 759350000716 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 759350000717 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 759350000718 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 759350000719 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 759350000720 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 759350000721 GatB domain; Region: GatB_Yqey; pfam02637 759350000722 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 759350000723 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 759350000724 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 759350000725 hypothetical protein; Provisional; Region: PRK07208 759350000726 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759350000727 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 759350000728 transcription termination factor Rho; Provisional; Region: PRK12608 759350000729 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 759350000730 RNA binding site [nucleotide binding]; other site 759350000731 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 759350000732 multimer interface [polypeptide binding]; other site 759350000733 Walker A motif; other site 759350000734 ATP binding site [chemical binding]; other site 759350000735 Walker B motif; other site 759350000736 monofunctional chorismate mutase, alpha proteobacterial type; Region: CM_mono_cladeE; TIGR01795 759350000737 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 759350000738 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759350000739 active site 759350000740 HIGH motif; other site 759350000741 nucleotide binding site [chemical binding]; other site 759350000742 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759350000743 active site 759350000744 KMSKS motif; other site 759350000745 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 759350000746 tRNA binding surface [nucleotide binding]; other site 759350000747 anticodon binding site; other site 759350000748 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 759350000749 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 759350000750 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 759350000751 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 759350000752 minor groove reading motif; other site 759350000753 helix-hairpin-helix signature motif; other site 759350000754 substrate binding pocket [chemical binding]; other site 759350000755 active site 759350000756 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 759350000757 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759350000758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759350000759 DNA binding site [nucleotide binding] 759350000760 Predicted membrane protein [Function unknown]; Region: COG1971 759350000761 Domain of unknown function DUF; Region: DUF204; pfam02659 759350000762 Domain of unknown function DUF; Region: DUF204; pfam02659 759350000763 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 759350000764 dimer interface [polypeptide binding]; other site 759350000765 substrate binding site [chemical binding]; other site 759350000766 metal binding sites [ion binding]; metal-binding site 759350000767 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 759350000768 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 759350000769 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 759350000770 active site 759350000771 homodimer interface [polypeptide binding]; other site 759350000772 catalytic site [active] 759350000773 acceptor binding site [chemical binding]; other site 759350000774 homoserine O-succinyltransferase; Provisional; Region: PRK05368 759350000775 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 759350000776 proposed active site lysine [active] 759350000777 conserved cys residue [active] 759350000778 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 759350000779 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 759350000780 ATP synthase subunit C; Region: ATP-synt_C; cl00466 759350000781 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 759350000782 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 759350000783 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 759350000784 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 759350000785 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 759350000786 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 759350000787 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 759350000788 beta subunit interaction interface [polypeptide binding]; other site 759350000789 Walker A motif; other site 759350000790 ATP binding site [chemical binding]; other site 759350000791 Walker B motif; other site 759350000792 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 759350000793 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 759350000794 core domain interface [polypeptide binding]; other site 759350000795 delta subunit interface [polypeptide binding]; other site 759350000796 epsilon subunit interface [polypeptide binding]; other site 759350000797 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 759350000798 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 759350000799 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 759350000800 alpha subunit interaction interface [polypeptide binding]; other site 759350000801 Walker A motif; other site 759350000802 ATP binding site [chemical binding]; other site 759350000803 Walker B motif; other site 759350000804 inhibitor binding site; inhibition site 759350000805 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 759350000806 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 759350000807 gamma subunit interface [polypeptide binding]; other site 759350000808 epsilon subunit interface [polypeptide binding]; other site 759350000809 LBP interface [polypeptide binding]; other site 759350000810 hypothetical protein; Provisional; Region: PRK03298 759350000811 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 759350000812 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 759350000813 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 759350000814 putative active site [active] 759350000815 putative metal binding residues [ion binding]; other site 759350000816 signature motif; other site 759350000817 putative dimer interface [polypeptide binding]; other site 759350000818 putative phosphate binding site [ion binding]; other site 759350000819 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 759350000820 homotrimer interaction site [polypeptide binding]; other site 759350000821 putative active site [active] 759350000822 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 759350000823 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 759350000824 putative acyl-acceptor binding pocket; other site 759350000825 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 759350000826 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 759350000827 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 759350000828 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 759350000829 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 759350000830 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 759350000831 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 759350000832 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 759350000833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 759350000834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350000835 dimer interface [polypeptide binding]; other site 759350000836 conserved gate region; other site 759350000837 putative PBP binding loops; other site 759350000838 ABC-ATPase subunit interface; other site 759350000839 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 759350000840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350000841 Walker A/P-loop; other site 759350000842 ATP binding site [chemical binding]; other site 759350000843 Q-loop/lid; other site 759350000844 ABC transporter signature motif; other site 759350000845 Walker B; other site 759350000846 D-loop; other site 759350000847 H-loop/switch region; other site 759350000848 TOBE domain; Region: TOBE_2; pfam08402 759350000849 CAAX protease self-immunity; Region: Abi; pfam02517 759350000850 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 759350000851 Mechanosensitive ion channel; Region: MS_channel; pfam00924 759350000852 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 759350000853 Aspartase; Region: Aspartase; cd01357 759350000854 active sites [active] 759350000855 tetramer interface [polypeptide binding]; other site 759350000856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759350000857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759350000858 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 759350000859 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 759350000860 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 759350000861 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 759350000862 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 759350000863 DNA binding site [nucleotide binding] 759350000864 active site 759350000865 MULE transposase domain; Region: MULE; pfam10551 759350000866 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 759350000867 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 759350000868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759350000869 non-specific DNA binding site [nucleotide binding]; other site 759350000870 salt bridge; other site 759350000871 sequence-specific DNA binding site [nucleotide binding]; other site 759350000872 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 759350000873 RelB antitoxin; Region: RelB; cl01171 759350000874 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 759350000875 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 759350000876 DNA binding residues [nucleotide binding] 759350000877 dimer interface [polypeptide binding]; other site 759350000878 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 759350000879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350000880 putative substrate translocation pore; other site 759350000881 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 759350000882 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 759350000883 substrate binding site [chemical binding]; other site 759350000884 ATP binding site [chemical binding]; other site 759350000885 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 759350000886 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 759350000887 ssDNA binding site; other site 759350000888 generic binding surface II; other site 759350000889 DEAD-like helicases superfamily; Region: DEXDc; smart00487 759350000890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759350000891 ATP binding site [chemical binding]; other site 759350000892 putative Mg++ binding site [ion binding]; other site 759350000893 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759350000894 nucleotide binding region [chemical binding]; other site 759350000895 ATP-binding site [chemical binding]; other site 759350000896 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350000897 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350000898 DNA binding site [nucleotide binding] 759350000899 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759350000900 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 759350000901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350000902 dimer interface [polypeptide binding]; other site 759350000903 conserved gate region; other site 759350000904 putative PBP binding loops; other site 759350000905 ABC-ATPase subunit interface; other site 759350000906 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350000907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350000908 dimer interface [polypeptide binding]; other site 759350000909 conserved gate region; other site 759350000910 putative PBP binding loops; other site 759350000911 ABC-ATPase subunit interface; other site 759350000912 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350000913 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 759350000914 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 759350000915 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 759350000916 metal binding site [ion binding]; metal-binding site 759350000917 substrate binding pocket [chemical binding]; other site 759350000918 short chain dehydrogenase; Provisional; Region: PRK08628 759350000919 classical (c) SDRs; Region: SDR_c; cd05233 759350000920 NAD(P) binding site [chemical binding]; other site 759350000921 active site 759350000922 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 759350000923 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 759350000924 inhibitor site; inhibition site 759350000925 active site 759350000926 dimer interface [polypeptide binding]; other site 759350000927 catalytic residue [active] 759350000928 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 759350000929 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 759350000930 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 759350000931 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 759350000932 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 759350000933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759350000934 S-adenosylmethionine binding site [chemical binding]; other site 759350000935 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 759350000936 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 759350000937 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 759350000938 Peptidase family U32; Region: Peptidase_U32; pfam01136 759350000939 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 759350000940 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 759350000941 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 759350000942 substrate binding site; other site 759350000943 dimer interface; other site 759350000944 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 759350000945 putative substrate binding pocket [chemical binding]; other site 759350000946 AC domain interface; other site 759350000947 catalytic triad [active] 759350000948 AB domain interface; other site 759350000949 interchain disulfide; other site 759350000950 DivIVA protein; Region: DivIVA; pfam05103 759350000951 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 759350000952 trimer interface [polypeptide binding]; other site 759350000953 active site 759350000954 G bulge; other site 759350000955 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 759350000956 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 759350000957 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 759350000958 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 759350000959 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 759350000960 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 759350000961 catalytic residues [active] 759350000962 catalytic nucleophile [active] 759350000963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 759350000964 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 759350000965 Probable transposase; Region: OrfB_IS605; pfam01385 759350000966 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 759350000967 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 759350000968 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 759350000969 metabolite-proton symporter; Region: 2A0106; TIGR00883 759350000970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350000971 putative substrate translocation pore; other site 759350000972 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 759350000973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759350000974 dimer interface [polypeptide binding]; other site 759350000975 phosphorylation site [posttranslational modification] 759350000976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759350000977 ATP binding site [chemical binding]; other site 759350000978 Mg2+ binding site [ion binding]; other site 759350000979 G-X-G motif; other site 759350000980 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759350000981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350000982 active site 759350000983 phosphorylation site [posttranslational modification] 759350000984 intermolecular recognition site; other site 759350000985 dimerization interface [polypeptide binding]; other site 759350000986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759350000987 DNA binding site [nucleotide binding] 759350000988 PBP superfamily domain; Region: PBP_like_2; cl17296 759350000989 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 759350000990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350000991 dimer interface [polypeptide binding]; other site 759350000992 conserved gate region; other site 759350000993 putative PBP binding loops; other site 759350000994 ABC-ATPase subunit interface; other site 759350000995 sulfate transport protein; Provisional; Region: cysT; CHL00187 759350000996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350000997 dimer interface [polypeptide binding]; other site 759350000998 conserved gate region; other site 759350000999 putative PBP binding loops; other site 759350001000 ABC-ATPase subunit interface; other site 759350001001 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 759350001002 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 759350001003 Walker A/P-loop; other site 759350001004 ATP binding site [chemical binding]; other site 759350001005 Q-loop/lid; other site 759350001006 ABC transporter signature motif; other site 759350001007 Walker B; other site 759350001008 D-loop; other site 759350001009 H-loop/switch region; other site 759350001010 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 759350001011 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 759350001012 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 759350001013 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 759350001014 Predicted membrane protein [Function unknown]; Region: COG4907 759350001015 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759350001016 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 759350001017 active site 759350001018 catalytic tetrad [active] 759350001019 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 759350001020 active site 759350001021 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 759350001022 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 759350001023 catalytic residues [active] 759350001024 catalytic nucleophile [active] 759350001025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 759350001026 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 759350001027 Probable transposase; Region: OrfB_IS605; pfam01385 759350001028 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 759350001029 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 759350001030 RimM N-terminal domain; Region: RimM; pfam01782 759350001031 hypothetical protein; Provisional; Region: PRK02821 759350001032 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 759350001033 G-X-X-G motif; other site 759350001034 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 759350001035 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 759350001036 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 759350001037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350001038 catalytic residue [active] 759350001039 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 759350001040 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 759350001041 chorismate binding enzyme; Region: Chorismate_bind; cl10555 759350001042 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 759350001043 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 759350001044 catalytic motif [active] 759350001045 Zn binding site [ion binding]; other site 759350001046 RibD C-terminal domain; Region: RibD_C; cl17279 759350001047 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 759350001048 Lumazine binding domain; Region: Lum_binding; pfam00677 759350001049 Lumazine binding domain; Region: Lum_binding; pfam00677 759350001050 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 759350001051 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 759350001052 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 759350001053 dimerization interface [polypeptide binding]; other site 759350001054 active site 759350001055 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 759350001056 homopentamer interface [polypeptide binding]; other site 759350001057 active site 759350001058 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 759350001059 putative catalytic site [active] 759350001060 putative metal binding site [ion binding]; other site 759350001061 putative phosphate binding site [ion binding]; other site 759350001062 signal recognition particle protein; Provisional; Region: PRK10867 759350001063 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 759350001064 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 759350001065 P loop; other site 759350001066 GTP binding site [chemical binding]; other site 759350001067 Signal peptide binding domain; Region: SRP_SPB; pfam02978 759350001068 Cation efflux family; Region: Cation_efflux; pfam01545 759350001069 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 759350001070 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759350001071 active site 759350001072 HIGH motif; other site 759350001073 nucleotide binding site [chemical binding]; other site 759350001074 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 759350001075 KMSKS motif; other site 759350001076 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 759350001077 tRNA binding surface [nucleotide binding]; other site 759350001078 anticodon binding site; other site 759350001079 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 759350001080 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 759350001081 catalytic triad [active] 759350001082 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350001083 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759350001084 ABC transporter; Region: ABC_tran_2; pfam12848 759350001085 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350001086 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759350001087 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 759350001088 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 759350001089 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 759350001090 putative valine binding site [chemical binding]; other site 759350001091 dimer interface [polypeptide binding]; other site 759350001092 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 759350001093 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 759350001094 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 759350001095 PYR/PP interface [polypeptide binding]; other site 759350001096 dimer interface [polypeptide binding]; other site 759350001097 TPP binding site [chemical binding]; other site 759350001098 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 759350001099 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 759350001100 TPP-binding site [chemical binding]; other site 759350001101 dimer interface [polypeptide binding]; other site 759350001102 ribonuclease III; Reviewed; Region: rnc; PRK00102 759350001103 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 759350001104 dimerization interface [polypeptide binding]; other site 759350001105 active site 759350001106 metal binding site [ion binding]; metal-binding site 759350001107 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 759350001108 dsRNA binding site [nucleotide binding]; other site 759350001109 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 759350001110 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 759350001111 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 759350001112 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 759350001113 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 759350001114 active site 759350001115 (T/H)XGH motif; other site 759350001116 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 759350001117 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759350001118 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 759350001119 active site 759350001120 catalytic tetrad [active] 759350001121 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 759350001122 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 759350001123 active site 759350001124 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 759350001125 non-specific DNA binding site [nucleotide binding]; other site 759350001126 salt bridge; other site 759350001127 sequence-specific DNA binding site [nucleotide binding]; other site 759350001128 ribonuclease PH; Reviewed; Region: rph; PRK00173 759350001129 Ribonuclease PH; Region: RNase_PH_bact; cd11362 759350001130 hexamer interface [polypeptide binding]; other site 759350001131 active site 759350001132 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 759350001133 active site 759350001134 dimerization interface [polypeptide binding]; other site 759350001135 FemAB family; Region: FemAB; pfam02388 759350001136 FemAB family; Region: FemAB; pfam02388 759350001137 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 759350001138 FemAB family; Region: FemAB; pfam02388 759350001139 Membrane transport protein; Region: Mem_trans; cl09117 759350001140 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 759350001141 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 759350001142 active site 759350001143 dimer interface [polypeptide binding]; other site 759350001144 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 759350001145 dimer interface [polypeptide binding]; other site 759350001146 active site 759350001147 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759350001148 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 759350001149 Walker A/P-loop; other site 759350001150 ATP binding site [chemical binding]; other site 759350001151 Q-loop/lid; other site 759350001152 ABC transporter signature motif; other site 759350001153 Walker B; other site 759350001154 D-loop; other site 759350001155 H-loop/switch region; other site 759350001156 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 759350001157 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 759350001158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001159 dimer interface [polypeptide binding]; other site 759350001160 conserved gate region; other site 759350001161 putative PBP binding loops; other site 759350001162 ABC-ATPase subunit interface; other site 759350001163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001164 dimer interface [polypeptide binding]; other site 759350001165 conserved gate region; other site 759350001166 putative PBP binding loops; other site 759350001167 ABC-ATPase subunit interface; other site 759350001168 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 759350001169 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 759350001170 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 759350001171 Catalytic site [active] 759350001172 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 759350001173 RNA/DNA hybrid binding site [nucleotide binding]; other site 759350001174 active site 759350001175 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350001176 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350001177 DNA binding site [nucleotide binding] 759350001178 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 759350001179 ligand binding site [chemical binding]; other site 759350001180 dimerization interface (open form) [polypeptide binding]; other site 759350001181 dimerization interface (closed form) [polypeptide binding]; other site 759350001182 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 759350001183 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 759350001184 putative N- and C-terminal domain interface [polypeptide binding]; other site 759350001185 putative active site [active] 759350001186 MgATP binding site [chemical binding]; other site 759350001187 catalytic site [active] 759350001188 metal binding site [ion binding]; metal-binding site 759350001189 putative carbohydrate binding site [chemical binding]; other site 759350001190 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 759350001191 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 759350001192 intersubunit interface [polypeptide binding]; other site 759350001193 active site 759350001194 Zn2+ binding site [ion binding]; other site 759350001195 L-arabinose isomerase; Provisional; Region: PRK02929 759350001196 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 759350001197 hexamer (dimer of trimers) interface [polypeptide binding]; other site 759350001198 trimer interface [polypeptide binding]; other site 759350001199 substrate binding site [chemical binding]; other site 759350001200 Mn binding site [ion binding]; other site 759350001201 Peptidase C26; Region: Peptidase_C26; pfam07722 759350001202 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 759350001203 catalytic triad [active] 759350001204 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 759350001205 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759350001206 FtsX-like permease family; Region: FtsX; pfam02687 759350001207 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759350001208 FtsX-like permease family; Region: FtsX; pfam02687 759350001209 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759350001210 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350001211 Walker A/P-loop; other site 759350001212 ATP binding site [chemical binding]; other site 759350001213 Q-loop/lid; other site 759350001214 ABC transporter signature motif; other site 759350001215 Walker B; other site 759350001216 D-loop; other site 759350001217 H-loop/switch region; other site 759350001218 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 759350001219 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 759350001220 acyl-activating enzyme (AAE) consensus motif; other site 759350001221 putative AMP binding site [chemical binding]; other site 759350001222 putative active site [active] 759350001223 putative CoA binding site [chemical binding]; other site 759350001224 fragment of arabinose permease; BLJ_0410 759350001225 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 759350001226 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350001227 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350001228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001229 dimer interface [polypeptide binding]; other site 759350001230 conserved gate region; other site 759350001231 putative PBP binding loops; other site 759350001232 ABC-ATPase subunit interface; other site 759350001233 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350001234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001235 dimer interface [polypeptide binding]; other site 759350001236 conserved gate region; other site 759350001237 putative PBP binding loops; other site 759350001238 ABC-ATPase subunit interface; other site 759350001239 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 759350001240 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 759350001241 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 759350001242 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 759350001243 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350001244 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350001245 DNA binding site [nucleotide binding] 759350001246 domain linker motif; other site 759350001247 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350001248 ligand binding site [chemical binding]; other site 759350001249 dimerization interface [polypeptide binding]; other site 759350001250 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 759350001251 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 759350001252 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759350001253 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 759350001254 active site 759350001255 catalytic tetrad [active] 759350001256 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 759350001257 AAA domain; Region: AAA_14; pfam13173 759350001258 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 759350001259 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 759350001260 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 759350001261 HTH-like domain; Region: HTH_21; pfam13276 759350001262 Integrase core domain; Region: rve; pfam00665 759350001263 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 759350001264 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759350001265 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 759350001266 Int/Topo IB signature motif; other site 759350001267 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 759350001268 Int/Topo IB signature motif; other site 759350001269 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 759350001270 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759350001271 active site 759350001272 DNA binding site [nucleotide binding] 759350001273 Int/Topo IB signature motif; other site 759350001274 Integrase core domain; Region: rve; pfam00665 759350001275 Integrase core domain; Region: rve_2; pfam13333 759350001276 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 759350001277 putative active site [active] 759350001278 comF family protein; Region: comF; TIGR00201 759350001279 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759350001280 active site 759350001281 DNA protecting protein DprA; Region: dprA; TIGR00732 759350001282 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 759350001283 Chain length determinant protein; Region: Wzz; cl15801 759350001284 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 759350001285 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 759350001286 Nucleotide binding site [chemical binding]; other site 759350001287 DTAP/Switch II; other site 759350001288 Switch I; other site 759350001289 Domain of unknown function (DUF348); Region: DUF348; pfam03990 759350001290 G5 domain; Region: G5; pfam07501 759350001291 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 759350001292 N-acetyl-D-glucosamine binding site [chemical binding]; other site 759350001293 catalytic residue [active] 759350001294 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 759350001295 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 759350001296 catalytic residues [active] 759350001297 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 759350001298 nudix motif; other site 759350001299 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 759350001300 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 759350001301 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 759350001302 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 759350001303 putative NADH binding site [chemical binding]; other site 759350001304 putative active site [active] 759350001305 nudix motif; other site 759350001306 putative metal binding site [ion binding]; other site 759350001307 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 759350001308 lipoyl attachment site [posttranslational modification]; other site 759350001309 Uncharacterized conserved protein [Function unknown]; Region: COG4850 759350001310 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 759350001311 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 759350001312 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 759350001313 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 759350001314 tartrate dehydrogenase; Region: TTC; TIGR02089 759350001315 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 759350001316 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 759350001317 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 759350001318 ligand binding site [chemical binding]; other site 759350001319 flexible hinge region; other site 759350001320 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 759350001321 putative switch regulator; other site 759350001322 non-specific DNA interactions [nucleotide binding]; other site 759350001323 DNA binding site [nucleotide binding] 759350001324 sequence specific DNA binding site [nucleotide binding]; other site 759350001325 putative cAMP binding site [chemical binding]; other site 759350001326 Transglycosylase; Region: Transgly; pfam00912 759350001327 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 759350001328 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 759350001329 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 759350001330 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 759350001331 active site 759350001332 FMN binding site [chemical binding]; other site 759350001333 substrate binding site [chemical binding]; other site 759350001334 homotetramer interface [polypeptide binding]; other site 759350001335 catalytic residue [active] 759350001336 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 759350001337 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 759350001338 quinone interaction residues [chemical binding]; other site 759350001339 active site 759350001340 catalytic residues [active] 759350001341 FMN binding site [chemical binding]; other site 759350001342 substrate binding site [chemical binding]; other site 759350001343 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 759350001344 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 759350001345 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 759350001346 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 759350001347 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 759350001348 dimer interface [polypeptide binding]; other site 759350001349 active site 759350001350 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 759350001351 galactokinase; Provisional; Region: PRK05322 759350001352 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 759350001353 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 759350001354 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350001355 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 759350001356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001357 dimer interface [polypeptide binding]; other site 759350001358 conserved gate region; other site 759350001359 putative PBP binding loops; other site 759350001360 ABC-ATPase subunit interface; other site 759350001361 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350001362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001363 dimer interface [polypeptide binding]; other site 759350001364 conserved gate region; other site 759350001365 putative PBP binding loops; other site 759350001366 ABC-ATPase subunit interface; other site 759350001367 Protein of unknown function, DUF624; Region: DUF624; pfam04854 759350001368 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350001369 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350001370 DNA binding site [nucleotide binding] 759350001371 domain linker motif; other site 759350001372 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 759350001373 putative dimerization interface [polypeptide binding]; other site 759350001374 putative ligand binding site [chemical binding]; other site 759350001375 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 759350001376 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 759350001377 substrate binding [chemical binding]; other site 759350001378 active site 759350001379 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 759350001380 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 759350001381 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 759350001382 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 759350001383 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 759350001384 minor groove reading motif; other site 759350001385 helix-hairpin-helix signature motif; other site 759350001386 active site 759350001387 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 759350001388 Alphaherpesvirus tegument protein US9; Region: Herpes_US9; pfam06072 759350001389 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 759350001390 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 759350001391 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 759350001392 RPB1 interaction site [polypeptide binding]; other site 759350001393 RPB10 interaction site [polypeptide binding]; other site 759350001394 RPB11 interaction site [polypeptide binding]; other site 759350001395 RPB3 interaction site [polypeptide binding]; other site 759350001396 RPB12 interaction site [polypeptide binding]; other site 759350001397 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 759350001398 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 759350001399 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 759350001400 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 759350001401 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 759350001402 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 759350001403 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 759350001404 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 759350001405 DNA binding site [nucleotide binding] 759350001406 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 759350001407 chromosome segregation protein; Provisional; Region: PRK02224 759350001408 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 759350001409 AAA domain; Region: AAA_14; pfam13173 759350001410 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 759350001411 phosphopeptide binding site; other site 759350001412 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 759350001413 Double zinc ribbon; Region: DZR; pfam12773 759350001414 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 759350001415 phosphopeptide binding site; other site 759350001416 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 759350001417 active site 759350001418 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 759350001419 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 759350001420 Protein of unknown function DUF58; Region: DUF58; pfam01882 759350001421 MoxR-like ATPases [General function prediction only]; Region: COG0714 759350001422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350001423 Walker A motif; other site 759350001424 ATP binding site [chemical binding]; other site 759350001425 Walker B motif; other site 759350001426 arginine finger; other site 759350001427 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 759350001428 Interdomain contacts; other site 759350001429 Cytokine receptor motif; other site 759350001430 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 759350001431 Interdomain contacts; other site 759350001432 Cytokine receptor motif; other site 759350001433 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 759350001434 Catalytic domain of Protein Kinases; Region: PKc; cd00180 759350001435 active site 759350001436 ATP binding site [chemical binding]; other site 759350001437 substrate binding site [chemical binding]; other site 759350001438 activation loop (A-loop); other site 759350001439 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 759350001440 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 759350001441 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 759350001442 Part of AAA domain; Region: AAA_19; pfam13245 759350001443 Family description; Region: UvrD_C_2; pfam13538 759350001444 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 759350001445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759350001446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350001447 dihydrodipicolinate reductase; Provisional; Region: PRK00048 759350001448 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 759350001449 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 759350001450 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 759350001451 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 759350001452 dimer interface [polypeptide binding]; other site 759350001453 active site 759350001454 catalytic residue [active] 759350001455 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 759350001456 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 759350001457 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 759350001458 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 759350001459 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 759350001460 Zn binding site [ion binding]; other site 759350001461 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 759350001462 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 759350001463 Helix-turn-helix domain; Region: HTH_38; pfam13936 759350001464 Integrase core domain; Region: rve; pfam00665 759350001465 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 759350001466 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 759350001467 active site 759350001468 substrate binding site [chemical binding]; other site 759350001469 metal binding site [ion binding]; metal-binding site 759350001470 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 759350001471 active site 759350001472 catalytic residues [active] 759350001473 metal binding site [ion binding]; metal-binding site 759350001474 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 759350001475 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 759350001476 active site 759350001477 substrate binding site [chemical binding]; other site 759350001478 catalytic site [active] 759350001479 AAA domain; Region: AAA_14; pfam13173 759350001480 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 759350001481 peptide chain release factor 2; Validated; Region: prfB; PRK00578 759350001482 This domain is found in peptide chain release factors; Region: PCRF; smart00937 759350001483 RF-1 domain; Region: RF-1; pfam00472 759350001484 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 759350001485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350001486 Walker A/P-loop; other site 759350001487 ATP binding site [chemical binding]; other site 759350001488 Q-loop/lid; other site 759350001489 ABC transporter signature motif; other site 759350001490 Walker B; other site 759350001491 D-loop; other site 759350001492 H-loop/switch region; other site 759350001493 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 759350001494 FtsX-like permease family; Region: FtsX; pfam02687 759350001495 Surface antigen [General function prediction only]; Region: COG3942 759350001496 CHAP domain; Region: CHAP; pfam05257 759350001497 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 759350001498 SmpB-tmRNA interface; other site 759350001499 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759350001500 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759350001501 substrate binding pocket [chemical binding]; other site 759350001502 membrane-bound complex binding site; other site 759350001503 hinge residues; other site 759350001504 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759350001505 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759350001506 substrate binding pocket [chemical binding]; other site 759350001507 membrane-bound complex binding site; other site 759350001508 hinge residues; other site 759350001509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001510 dimer interface [polypeptide binding]; other site 759350001511 conserved gate region; other site 759350001512 putative PBP binding loops; other site 759350001513 ABC-ATPase subunit interface; other site 759350001514 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 759350001515 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 759350001516 Walker A/P-loop; other site 759350001517 ATP binding site [chemical binding]; other site 759350001518 Q-loop/lid; other site 759350001519 ABC transporter signature motif; other site 759350001520 Walker B; other site 759350001521 D-loop; other site 759350001522 H-loop/switch region; other site 759350001523 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 759350001524 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 759350001525 glutaminase active site [active] 759350001526 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 759350001527 dimer interface [polypeptide binding]; other site 759350001528 active site 759350001529 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 759350001530 dimer interface [polypeptide binding]; other site 759350001531 active site 759350001532 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 759350001533 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 759350001534 active site 759350001535 HipA N-terminal domain; Region: Couple_hipA; pfam13657 759350001536 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 759350001537 HipA-like N-terminal domain; Region: HipA_N; pfam07805 759350001538 HipA-like C-terminal domain; Region: HipA_C; pfam07804 759350001539 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 759350001540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759350001541 non-specific DNA binding site [nucleotide binding]; other site 759350001542 salt bridge; other site 759350001543 sequence-specific DNA binding site [nucleotide binding]; other site 759350001544 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350001545 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350001546 DNA binding site [nucleotide binding] 759350001547 domain linker motif; other site 759350001548 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 759350001549 ligand binding site [chemical binding]; other site 759350001550 dimerization interface (open form) [polypeptide binding]; other site 759350001551 dimerization interface (closed form) [polypeptide binding]; other site 759350001552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001553 dimer interface [polypeptide binding]; other site 759350001554 conserved gate region; other site 759350001555 putative PBP binding loops; other site 759350001556 ABC-ATPase subunit interface; other site 759350001557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350001558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001559 dimer interface [polypeptide binding]; other site 759350001560 conserved gate region; other site 759350001561 putative PBP binding loops; other site 759350001562 ABC-ATPase subunit interface; other site 759350001563 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 759350001564 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 759350001565 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 759350001566 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350001567 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350001568 DNA binding site [nucleotide binding] 759350001569 domain linker motif; other site 759350001570 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350001571 ligand binding site [chemical binding]; other site 759350001572 dimerization interface [polypeptide binding]; other site 759350001573 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 759350001574 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 759350001575 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350001576 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350001577 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350001578 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350001579 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350001580 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350001581 pantothenate kinase; Reviewed; Region: PRK13318 759350001582 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 759350001583 Flavoprotein; Region: Flavoprotein; pfam02441 759350001584 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 759350001585 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759350001586 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 759350001587 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759350001588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001589 dimer interface [polypeptide binding]; other site 759350001590 conserved gate region; other site 759350001591 putative PBP binding loops; other site 759350001592 ABC-ATPase subunit interface; other site 759350001593 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759350001594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001595 dimer interface [polypeptide binding]; other site 759350001596 conserved gate region; other site 759350001597 putative PBP binding loops; other site 759350001598 ABC-ATPase subunit interface; other site 759350001599 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759350001600 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759350001601 Walker A/P-loop; other site 759350001602 ATP binding site [chemical binding]; other site 759350001603 Q-loop/lid; other site 759350001604 ABC transporter signature motif; other site 759350001605 Walker B; other site 759350001606 D-loop; other site 759350001607 H-loop/switch region; other site 759350001608 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759350001609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759350001610 Walker A/P-loop; other site 759350001611 ATP binding site [chemical binding]; other site 759350001612 Q-loop/lid; other site 759350001613 ABC transporter signature motif; other site 759350001614 Walker B; other site 759350001615 D-loop; other site 759350001616 H-loop/switch region; other site 759350001617 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759350001618 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 759350001619 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 759350001620 dimer interface [polypeptide binding]; other site 759350001621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350001622 catalytic residue [active] 759350001623 cystathionine gamma-synthase; Provisional; Region: PRK07811 759350001624 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 759350001625 homodimer interface [polypeptide binding]; other site 759350001626 substrate-cofactor binding pocket; other site 759350001627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350001628 catalytic residue [active] 759350001629 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 759350001630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 759350001631 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 759350001632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759350001633 ATP binding site [chemical binding]; other site 759350001634 putative Mg++ binding site [ion binding]; other site 759350001635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759350001636 nucleotide binding region [chemical binding]; other site 759350001637 ATP-binding site [chemical binding]; other site 759350001638 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 759350001639 HRDC domain; Region: HRDC; pfam00570 759350001640 S-ribosylhomocysteinase; Provisional; Region: PRK02260 759350001641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 759350001642 amino acid transporter; Region: 2A0306; TIGR00909 759350001643 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 759350001644 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 759350001645 alanine racemase; Reviewed; Region: alr; PRK00053 759350001646 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 759350001647 active site 759350001648 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759350001649 dimer interface [polypeptide binding]; other site 759350001650 substrate binding site [chemical binding]; other site 759350001651 catalytic residues [active] 759350001652 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 759350001653 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759350001654 Zn2+ binding site [ion binding]; other site 759350001655 Mg2+ binding site [ion binding]; other site 759350001656 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 759350001657 DNA primase, catalytic core; Region: dnaG; TIGR01391 759350001658 CHC2 zinc finger; Region: zf-CHC2; cl17510 759350001659 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 759350001660 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 759350001661 active site 759350001662 metal binding site [ion binding]; metal-binding site 759350001663 interdomain interaction site; other site 759350001664 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 759350001665 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 759350001666 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 759350001667 active site 759350001668 multimer interface [polypeptide binding]; other site 759350001669 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 759350001670 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 759350001671 predicted active site [active] 759350001672 catalytic triad [active] 759350001673 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 759350001674 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759350001675 DNA-binding site [nucleotide binding]; DNA binding site 759350001676 Rhoptry-associated protein 1 (RAP-1); Region: RAP1; pfam07218 759350001677 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 759350001678 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759350001679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350001680 homodimer interface [polypeptide binding]; other site 759350001681 catalytic residue [active] 759350001682 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 759350001683 catalytic nucleophile [active] 759350001684 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 759350001685 transmembrane helices; other site 759350001686 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 759350001687 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 759350001688 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 759350001689 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 759350001690 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 759350001691 putative active site [active] 759350001692 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 759350001693 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350001694 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759350001695 Walker A/P-loop; other site 759350001696 ATP binding site [chemical binding]; other site 759350001697 Q-loop/lid; other site 759350001698 ABC transporter signature motif; other site 759350001699 Walker B; other site 759350001700 D-loop; other site 759350001701 H-loop/switch region; other site 759350001702 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 759350001703 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 759350001704 FtsX-like permease family; Region: FtsX; pfam02687 759350001705 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 759350001706 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 759350001707 TPP-binding site; other site 759350001708 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 759350001709 PYR/PP interface [polypeptide binding]; other site 759350001710 dimer interface [polypeptide binding]; other site 759350001711 TPP binding site [chemical binding]; other site 759350001712 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 759350001713 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 759350001714 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 759350001715 NAD(P) binding site [chemical binding]; other site 759350001716 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 759350001717 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 759350001718 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 759350001719 NAD binding site [chemical binding]; other site 759350001720 ATP-grasp domain; Region: ATP-grasp; pfam02222 759350001721 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 759350001722 metal binding site 2 [ion binding]; metal-binding site 759350001723 putative DNA binding helix; other site 759350001724 metal binding site 1 [ion binding]; metal-binding site 759350001725 dimer interface [polypeptide binding]; other site 759350001726 structural Zn2+ binding site [ion binding]; other site 759350001727 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 759350001728 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 759350001729 metal binding site [ion binding]; metal-binding site 759350001730 Sulfatase; Region: Sulfatase; pfam00884 759350001731 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 759350001732 NAD(P) binding site [chemical binding]; other site 759350001733 catalytic residues [active] 759350001734 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 759350001735 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 759350001736 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 759350001737 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 759350001738 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 759350001739 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 759350001740 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 759350001741 dimerization interface [polypeptide binding]; other site 759350001742 putative ATP binding site [chemical binding]; other site 759350001743 amidophosphoribosyltransferase; Provisional; Region: PRK07272 759350001744 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 759350001745 active site 759350001746 tetramer interface [polypeptide binding]; other site 759350001747 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759350001748 active site 759350001749 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 759350001750 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 759350001751 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 759350001752 DNA polymerase IV; Reviewed; Region: PRK03103 759350001753 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 759350001754 active site 759350001755 DNA binding site [nucleotide binding] 759350001756 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 759350001757 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 759350001758 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 759350001759 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 759350001760 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 759350001761 putative active site [active] 759350001762 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 759350001763 Yqey-like protein; Region: YqeY; cl17540 759350001764 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 759350001765 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 759350001766 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 759350001767 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 759350001768 dimerization interface [polypeptide binding]; other site 759350001769 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 759350001770 dimerization interface [polypeptide binding]; other site 759350001771 ATP binding site [chemical binding]; other site 759350001772 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 759350001773 dimerization interface [polypeptide binding]; other site 759350001774 ATP binding site [chemical binding]; other site 759350001775 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 759350001776 putative active site [active] 759350001777 catalytic triad [active] 759350001778 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 759350001779 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 759350001780 ATP binding site [chemical binding]; other site 759350001781 active site 759350001782 substrate binding site [chemical binding]; other site 759350001783 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 759350001784 ATP-grasp domain; Region: ATP-grasp; pfam02222 759350001785 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 759350001786 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 759350001787 putative ADP-binding pocket [chemical binding]; other site 759350001788 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 759350001789 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 759350001790 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759350001791 catalytic residue [active] 759350001792 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 759350001793 Sodium Bile acid symporter family; Region: SBF; pfam01758 759350001794 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 759350001795 S17 interaction site [polypeptide binding]; other site 759350001796 S8 interaction site; other site 759350001797 16S rRNA interaction site [nucleotide binding]; other site 759350001798 streptomycin interaction site [chemical binding]; other site 759350001799 23S rRNA interaction site [nucleotide binding]; other site 759350001800 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 759350001801 30S ribosomal protein S7; Validated; Region: PRK05302 759350001802 elongation factor G; Reviewed; Region: PRK00007 759350001803 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 759350001804 G1 box; other site 759350001805 putative GEF interaction site [polypeptide binding]; other site 759350001806 GTP/Mg2+ binding site [chemical binding]; other site 759350001807 Switch I region; other site 759350001808 G2 box; other site 759350001809 G3 box; other site 759350001810 Switch II region; other site 759350001811 G4 box; other site 759350001812 G5 box; other site 759350001813 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 759350001814 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 759350001815 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 759350001816 elongation factor Tu; Reviewed; Region: PRK00049 759350001817 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 759350001818 G1 box; other site 759350001819 GEF interaction site [polypeptide binding]; other site 759350001820 GTP/Mg2+ binding site [chemical binding]; other site 759350001821 Switch I region; other site 759350001822 G2 box; other site 759350001823 G3 box; other site 759350001824 Switch II region; other site 759350001825 G4 box; other site 759350001826 G5 box; other site 759350001827 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 759350001828 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 759350001829 Antibiotic Binding Site [chemical binding]; other site 759350001830 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 759350001831 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759350001832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759350001833 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759350001834 dimerization interface [polypeptide binding]; other site 759350001835 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 759350001836 CrcB-like protein; Region: CRCB; pfam02537 759350001837 CrcB-like protein; Region: CRCB; pfam02537 759350001838 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 759350001839 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 759350001840 catalytic Zn binding site [ion binding]; other site 759350001841 NAD(P) binding site [chemical binding]; other site 759350001842 structural Zn binding site [ion binding]; other site 759350001843 AAA domain; Region: AAA_14; pfam13173 759350001844 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 759350001845 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 759350001846 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 759350001847 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 759350001848 putative active site [active] 759350001849 catalytic site [active] 759350001850 putative metal binding site [ion binding]; other site 759350001851 oligomer interface [polypeptide binding]; other site 759350001852 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350001853 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 759350001854 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350001855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001856 dimer interface [polypeptide binding]; other site 759350001857 conserved gate region; other site 759350001858 putative PBP binding loops; other site 759350001859 ABC-ATPase subunit interface; other site 759350001860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350001861 dimer interface [polypeptide binding]; other site 759350001862 conserved gate region; other site 759350001863 putative PBP binding loops; other site 759350001864 ABC-ATPase subunit interface; other site 759350001865 Phosphate transporter family; Region: PHO4; pfam01384 759350001866 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350001867 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350001868 DNA binding site [nucleotide binding] 759350001869 domain linker motif; other site 759350001870 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350001871 dimerization interface [polypeptide binding]; other site 759350001872 ligand binding site [chemical binding]; other site 759350001873 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 759350001874 MarR family; Region: MarR_2; pfam12802 759350001875 KDPG and KHG aldolase; Region: Aldolase; cl17259 759350001876 AAA domain; Region: AAA_14; pfam13173 759350001877 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 759350001878 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 759350001879 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 759350001880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350001881 Walker A/P-loop; other site 759350001882 ATP binding site [chemical binding]; other site 759350001883 Q-loop/lid; other site 759350001884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350001885 ABC transporter signature motif; other site 759350001886 Walker B; other site 759350001887 D-loop; other site 759350001888 H-loop/switch region; other site 759350001889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350001890 Walker A/P-loop; other site 759350001891 ATP binding site [chemical binding]; other site 759350001892 Q-loop/lid; other site 759350001893 ABC transporter signature motif; other site 759350001894 Walker B; other site 759350001895 D-loop; other site 759350001896 H-loop/switch region; other site 759350001897 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 759350001898 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759350001899 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 759350001900 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 759350001901 minor groove reading motif; other site 759350001902 helix-hairpin-helix signature motif; other site 759350001903 active site 759350001904 maltose O-acetyltransferase; Provisional; Region: PRK10092 759350001905 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 759350001906 active site 759350001907 substrate binding site [chemical binding]; other site 759350001908 trimer interface [polypeptide binding]; other site 759350001909 CoA binding site [chemical binding]; other site 759350001910 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 759350001911 putative CoA binding site [chemical binding]; other site 759350001912 putative trimer interface [polypeptide binding]; other site 759350001913 Predicted permeases [General function prediction only]; Region: COG0679 759350001914 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 759350001915 glutamine synthetase, type I; Region: GlnA; TIGR00653 759350001916 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 759350001917 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 759350001918 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 759350001919 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 759350001920 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 759350001921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759350001922 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 759350001923 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 759350001924 hypothetical protein; Provisional; Region: PRK07907 759350001925 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 759350001926 active site 759350001927 metal binding site [ion binding]; metal-binding site 759350001928 dimer interface [polypeptide binding]; other site 759350001929 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 759350001930 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 759350001931 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 759350001932 Walker A/P-loop; other site 759350001933 ATP binding site [chemical binding]; other site 759350001934 Q-loop/lid; other site 759350001935 ABC transporter signature motif; other site 759350001936 Walker B; other site 759350001937 D-loop; other site 759350001938 H-loop/switch region; other site 759350001939 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 759350001940 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 759350001941 Walker A/P-loop; other site 759350001942 ATP binding site [chemical binding]; other site 759350001943 Q-loop/lid; other site 759350001944 ABC transporter signature motif; other site 759350001945 Walker B; other site 759350001946 D-loop; other site 759350001947 H-loop/switch region; other site 759350001948 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 759350001949 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 759350001950 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 759350001951 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 759350001952 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 759350001953 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 759350001954 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 759350001955 dimer interface [polypeptide binding]; other site 759350001956 motif 1; other site 759350001957 active site 759350001958 motif 2; other site 759350001959 motif 3; other site 759350001960 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 759350001961 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 759350001962 putative tRNA-binding site [nucleotide binding]; other site 759350001963 B3/4 domain; Region: B3_4; pfam03483 759350001964 tRNA synthetase B5 domain; Region: B5; pfam03484 759350001965 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 759350001966 dimer interface [polypeptide binding]; other site 759350001967 motif 1; other site 759350001968 motif 3; other site 759350001969 motif 2; other site 759350001970 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 759350001971 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 759350001972 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 759350001973 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 759350001974 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 759350001975 heterotetramer interface [polypeptide binding]; other site 759350001976 active site pocket [active] 759350001977 cleavage site 759350001978 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 759350001979 feedback inhibition sensing region; other site 759350001980 homohexameric interface [polypeptide binding]; other site 759350001981 nucleotide binding site [chemical binding]; other site 759350001982 N-acetyl-L-glutamate binding site [chemical binding]; other site 759350001983 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 759350001984 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 759350001985 inhibitor-cofactor binding pocket; inhibition site 759350001986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350001987 catalytic residue [active] 759350001988 ornithine carbamoyltransferase; Provisional; Region: PRK00779 759350001989 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 759350001990 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 759350001991 arginine repressor; Provisional; Region: PRK03341 759350001992 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 759350001993 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 759350001994 argininosuccinate synthase; Provisional; Region: PRK13820 759350001995 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 759350001996 ANP binding site [chemical binding]; other site 759350001997 Substrate Binding Site II [chemical binding]; other site 759350001998 Substrate Binding Site I [chemical binding]; other site 759350001999 argininosuccinate lyase; Provisional; Region: PRK00855 759350002000 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 759350002001 active sites [active] 759350002002 tetramer interface [polypeptide binding]; other site 759350002003 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 759350002004 thiS-thiF/thiG interaction site; other site 759350002005 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 759350002006 ThiS interaction site; other site 759350002007 putative active site [active] 759350002008 tetramer interface [polypeptide binding]; other site 759350002009 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 759350002010 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 759350002011 ATP binding site [chemical binding]; other site 759350002012 substrate interface [chemical binding]; other site 759350002013 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 759350002014 active site residue [active] 759350002015 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759350002016 Zn2+ binding site [ion binding]; other site 759350002017 Mg2+ binding site [ion binding]; other site 759350002018 Predicted membrane protein [Function unknown]; Region: COG4905 759350002019 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 759350002020 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 759350002021 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 759350002022 active site 759350002023 HIGH motif; other site 759350002024 dimer interface [polypeptide binding]; other site 759350002025 KMSKS motif; other site 759350002026 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759350002027 RNA binding surface [nucleotide binding]; other site 759350002028 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 759350002029 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 759350002030 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 759350002031 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 759350002032 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759350002033 RNA binding surface [nucleotide binding]; other site 759350002034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759350002035 S-adenosylmethionine binding site [chemical binding]; other site 759350002036 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 759350002037 TrkA-N domain; Region: TrkA_N; pfam02254 759350002038 TrkA-C domain; Region: TrkA_C; pfam02080 759350002039 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 759350002040 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 759350002041 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 759350002042 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 759350002043 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 759350002044 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 759350002045 Walker A/P-loop; other site 759350002046 ATP binding site [chemical binding]; other site 759350002047 Q-loop/lid; other site 759350002048 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 759350002049 ABC transporter signature motif; other site 759350002050 Walker B; other site 759350002051 D-loop; other site 759350002052 H-loop/switch region; other site 759350002053 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 759350002054 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759350002055 motif II; other site 759350002056 Predicted transcriptional regulators [Transcription]; Region: COG1725 759350002057 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759350002058 DNA-binding site [nucleotide binding]; DNA binding site 759350002059 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 759350002060 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 759350002061 Walker A/P-loop; other site 759350002062 ATP binding site [chemical binding]; other site 759350002063 Q-loop/lid; other site 759350002064 ABC transporter signature motif; other site 759350002065 Walker B; other site 759350002066 D-loop; other site 759350002067 H-loop/switch region; other site 759350002068 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 759350002069 Divergent AAA domain; Region: AAA_4; pfam04326 759350002070 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 759350002071 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759350002072 putative DNA binding site [nucleotide binding]; other site 759350002073 putative Zn2+ binding site [ion binding]; other site 759350002074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759350002075 DNA-binding site [nucleotide binding]; DNA binding site 759350002076 Predicted membrane protein [General function prediction only]; Region: COG4194 759350002077 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 759350002078 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 759350002079 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 759350002080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350002081 catalytic residue [active] 759350002082 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 759350002083 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 759350002084 dimer interface [polypeptide binding]; other site 759350002085 active site 759350002086 glycine-pyridoxal phosphate binding site [chemical binding]; other site 759350002087 folate binding site [chemical binding]; other site 759350002088 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 759350002089 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 759350002090 putative catalytic cysteine [active] 759350002091 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 759350002092 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 759350002093 active site 759350002094 (T/H)XGH motif; other site 759350002095 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 759350002096 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 759350002097 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 759350002098 Uncharacterized conserved protein [Function unknown]; Region: COG1615 759350002099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 759350002100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759350002101 Coenzyme A binding pocket [chemical binding]; other site 759350002102 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 759350002103 RelB antitoxin; Region: RelB; cl01171 759350002104 Large family of predicted nucleotide-binding domains; Region: PINc; smart00670 759350002105 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 759350002106 putative active site [active] 759350002107 catalytic residue [active] 759350002108 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 759350002109 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 759350002110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759350002111 ATP binding site [chemical binding]; other site 759350002112 putative Mg++ binding site [ion binding]; other site 759350002113 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759350002114 nucleotide binding region [chemical binding]; other site 759350002115 ATP-binding site [chemical binding]; other site 759350002116 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 759350002117 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759350002118 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 759350002119 active site 759350002120 catalytic tetrad [active] 759350002121 enolase; Provisional; Region: eno; PRK00077 759350002122 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 759350002123 dimer interface [polypeptide binding]; other site 759350002124 metal binding site [ion binding]; metal-binding site 759350002125 substrate binding pocket [chemical binding]; other site 759350002126 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 759350002127 Septum formation initiator; Region: DivIC; pfam04977 759350002128 Protein of unknown function (DUF501); Region: DUF501; pfam04417 759350002129 exopolyphosphatase; Region: exo_poly_only; TIGR03706 759350002130 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 759350002131 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 759350002132 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 759350002133 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 759350002134 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 759350002135 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 759350002136 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 759350002137 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 759350002138 Haemolysin-III related; Region: HlyIII; pfam03006 759350002139 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 759350002140 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 759350002141 Double zinc ribbon; Region: DZR; pfam12773 759350002142 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 759350002143 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 759350002144 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 759350002145 PAS fold; Region: PAS_4; pfam08448 759350002146 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 759350002147 Histidine kinase; Region: HisKA_2; pfam07568 759350002148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759350002149 ATP binding site [chemical binding]; other site 759350002150 Mg2+ binding site [ion binding]; other site 759350002151 G-X-G motif; other site 759350002152 Transcription factor WhiB; Region: Whib; pfam02467 759350002153 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 759350002154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350002155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 759350002156 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759350002157 Walker A motif; other site 759350002158 Walker A/P-loop; other site 759350002159 ATP binding site [chemical binding]; other site 759350002160 ATP binding site [chemical binding]; other site 759350002161 Walker B motif; other site 759350002162 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 759350002163 Transcription factor WhiB; Region: Whib; pfam02467 759350002164 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 759350002165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759350002166 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 759350002167 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 759350002168 Eukaryotic phosphomannomutase; Region: PMM; cl17107 759350002169 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 759350002170 Catalytic site [active] 759350002171 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759350002172 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 759350002173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 759350002174 dimerization interface [polypeptide binding]; other site 759350002175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759350002176 dimer interface [polypeptide binding]; other site 759350002177 phosphorylation site [posttranslational modification] 759350002178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759350002179 ATP binding site [chemical binding]; other site 759350002180 Mg2+ binding site [ion binding]; other site 759350002181 G-X-G motif; other site 759350002182 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759350002183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350002184 active site 759350002185 phosphorylation site [posttranslational modification] 759350002186 intermolecular recognition site; other site 759350002187 dimerization interface [polypeptide binding]; other site 759350002188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759350002189 DNA binding site [nucleotide binding] 759350002190 glycogen branching enzyme; Provisional; Region: PRK05402 759350002191 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 759350002192 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 759350002193 active site 759350002194 catalytic site [active] 759350002195 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 759350002196 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 759350002197 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 759350002198 homotrimer interaction site [polypeptide binding]; other site 759350002199 zinc binding site [ion binding]; other site 759350002200 CDP-binding sites; other site 759350002201 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 759350002202 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759350002203 ABC-ATPase subunit interface; other site 759350002204 dimer interface [polypeptide binding]; other site 759350002205 putative PBP binding regions; other site 759350002206 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 759350002207 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 759350002208 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 759350002209 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 759350002210 metal binding site [ion binding]; metal-binding site 759350002211 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 759350002212 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 759350002213 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 759350002214 homodimer interface [polypeptide binding]; other site 759350002215 NADP binding site [chemical binding]; other site 759350002216 substrate binding site [chemical binding]; other site 759350002217 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 759350002218 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 759350002219 RNA binding site [nucleotide binding]; other site 759350002220 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 759350002221 RNA binding site [nucleotide binding]; other site 759350002222 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 759350002223 RNA binding site [nucleotide binding]; other site 759350002224 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 759350002225 RNA binding site [nucleotide binding]; other site 759350002226 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 759350002227 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 759350002228 CoA-binding site [chemical binding]; other site 759350002229 ATP-binding [chemical binding]; other site 759350002230 excinuclease ABC subunit B; Provisional; Region: PRK05298 759350002231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759350002232 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759350002233 nucleotide binding region [chemical binding]; other site 759350002234 ATP-binding site [chemical binding]; other site 759350002235 Ultra-violet resistance protein B; Region: UvrB; pfam12344 759350002236 UvrB/uvrC motif; Region: UVR; pfam02151 759350002237 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 759350002238 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 759350002239 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 759350002240 domain interfaces; other site 759350002241 active site 759350002242 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 759350002243 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 759350002244 dimer interface [polypeptide binding]; other site 759350002245 ADP-ribose binding site [chemical binding]; other site 759350002246 active site 759350002247 nudix motif; other site 759350002248 metal binding site [ion binding]; metal-binding site 759350002249 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 759350002250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350002251 active site 759350002252 phosphorylation site [posttranslational modification] 759350002253 intermolecular recognition site; other site 759350002254 dimerization interface [polypeptide binding]; other site 759350002255 ANTAR domain; Region: ANTAR; pfam03861 759350002256 DNA polymerase I; Provisional; Region: PRK05755 759350002257 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 759350002258 active site 759350002259 metal binding site 1 [ion binding]; metal-binding site 759350002260 putative 5' ssDNA interaction site; other site 759350002261 metal binding site 3; metal-binding site 759350002262 metal binding site 2 [ion binding]; metal-binding site 759350002263 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 759350002264 putative DNA binding site [nucleotide binding]; other site 759350002265 putative metal binding site [ion binding]; other site 759350002266 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 759350002267 active site 759350002268 substrate binding site [chemical binding]; other site 759350002269 catalytic site [active] 759350002270 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 759350002271 active site 759350002272 DNA binding site [nucleotide binding] 759350002273 catalytic site [active] 759350002274 Uncharacterized conserved protein [Function unknown]; Region: COG0327 759350002275 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 759350002276 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 759350002277 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 759350002278 dimer interface [polypeptide binding]; other site 759350002279 ADP-ribose binding site [chemical binding]; other site 759350002280 active site 759350002281 nudix motif; other site 759350002282 metal binding site [ion binding]; metal-binding site 759350002283 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 759350002284 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 759350002285 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 759350002286 active site 759350002287 catalytic site [active] 759350002288 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 759350002289 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 759350002290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759350002291 non-specific DNA binding site [nucleotide binding]; other site 759350002292 salt bridge; other site 759350002293 sequence-specific DNA binding site [nucleotide binding]; other site 759350002294 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 759350002295 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 759350002296 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 759350002297 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 759350002298 HTH-like domain; Region: HTH_21; pfam13276 759350002299 Integrase core domain; Region: rve; pfam00665 759350002300 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 759350002301 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759350002302 active site 759350002303 DNA binding site [nucleotide binding] 759350002304 Int/Topo IB signature motif; other site 759350002305 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 759350002306 Int/Topo IB signature motif; other site 759350002307 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 759350002308 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759350002309 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 759350002310 Int/Topo IB signature motif; other site 759350002311 Integrase core domain; Region: rve_3; cl15866 759350002312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 759350002313 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759350002314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350002315 phosphorylation site [posttranslational modification] 759350002316 intermolecular recognition site; other site 759350002317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 759350002318 DNA binding residues [nucleotide binding] 759350002319 dimerization interface [polypeptide binding]; other site 759350002320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350002321 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 759350002322 Walker A/P-loop; other site 759350002323 ATP binding site [chemical binding]; other site 759350002324 Q-loop/lid; other site 759350002325 ABC transporter signature motif; other site 759350002326 Walker B; other site 759350002327 D-loop; other site 759350002328 H-loop/switch region; other site 759350002329 Transposase; Region: DDE_Tnp_ISL3; pfam01610 759350002330 MULE transposase domain; Region: MULE; pfam10551 759350002331 putative transposase OrfB; Reviewed; Region: PHA02517 759350002332 HTH-like domain; Region: HTH_21; pfam13276 759350002333 Integrase core domain; Region: rve; pfam00665 759350002334 Integrase core domain; Region: rve_2; pfam13333 759350002335 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 759350002336 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 759350002337 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 759350002338 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 759350002339 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 759350002340 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 759350002341 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 759350002342 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 759350002343 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 759350002344 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 759350002345 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 759350002346 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 759350002347 hinge; other site 759350002348 active site 759350002349 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 759350002350 propionate/acetate kinase; Provisional; Region: PRK12379 759350002351 AAA domain; Region: AAA_26; pfam13500 759350002352 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 759350002353 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759350002354 catalytic core [active] 759350002355 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 759350002356 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 759350002357 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 759350002358 Substrate binding site; other site 759350002359 Mg++ binding site; other site 759350002360 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 759350002361 active site 759350002362 substrate binding site [chemical binding]; other site 759350002363 CoA binding site [chemical binding]; other site 759350002364 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 759350002365 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 759350002366 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759350002367 active site 759350002368 Acyltransferase family; Region: Acyl_transf_3; pfam01757 759350002369 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 759350002370 catalytic triad [active] 759350002371 catalytic triad [active] 759350002372 oxyanion hole [active] 759350002373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 759350002374 GMP synthase; Reviewed; Region: guaA; PRK00074 759350002375 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 759350002376 AMP/PPi binding site [chemical binding]; other site 759350002377 candidate oxyanion hole; other site 759350002378 catalytic triad [active] 759350002379 potential glutamine specificity residues [chemical binding]; other site 759350002380 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 759350002381 ATP Binding subdomain [chemical binding]; other site 759350002382 Ligand Binding sites [chemical binding]; other site 759350002383 Dimerization subdomain; other site 759350002384 putative phosphoketolase; Provisional; Region: PRK05261 759350002385 XFP N-terminal domain; Region: XFP_N; pfam09364 759350002386 XFP C-terminal domain; Region: XFP_C; pfam09363 759350002387 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 759350002388 HlyD family secretion protein; Region: HlyD_3; pfam13437 759350002389 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350002390 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759350002391 Walker A/P-loop; other site 759350002392 ATP binding site [chemical binding]; other site 759350002393 Q-loop/lid; other site 759350002394 ABC transporter signature motif; other site 759350002395 Walker B; other site 759350002396 D-loop; other site 759350002397 H-loop/switch region; other site 759350002398 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759350002399 FtsX-like permease family; Region: FtsX; pfam02687 759350002400 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 759350002401 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759350002402 active site 759350002403 motif I; other site 759350002404 motif II; other site 759350002405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 759350002406 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 759350002407 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 759350002408 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 759350002409 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 759350002410 Walker A/P-loop; other site 759350002411 ATP binding site [chemical binding]; other site 759350002412 Q-loop/lid; other site 759350002413 ABC transporter signature motif; other site 759350002414 Walker B; other site 759350002415 D-loop; other site 759350002416 H-loop/switch region; other site 759350002417 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 759350002418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 759350002419 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 759350002420 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 759350002421 metal binding site [ion binding]; metal-binding site 759350002422 NAD synthetase; Provisional; Region: PRK13981 759350002423 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 759350002424 multimer interface [polypeptide binding]; other site 759350002425 active site 759350002426 catalytic triad [active] 759350002427 protein interface 1 [polypeptide binding]; other site 759350002428 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 759350002429 homodimer interface [polypeptide binding]; other site 759350002430 NAD binding pocket [chemical binding]; other site 759350002431 ATP binding pocket [chemical binding]; other site 759350002432 Mg binding site [ion binding]; other site 759350002433 active-site loop [active] 759350002434 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 759350002435 Pyruvate formate lyase 1; Region: PFL1; cd01678 759350002436 coenzyme A binding site [chemical binding]; other site 759350002437 active site 759350002438 catalytic residues [active] 759350002439 glycine loop; other site 759350002440 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 759350002441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759350002442 FeS/SAM binding site; other site 759350002443 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 759350002444 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 759350002445 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 759350002446 active site 759350002447 catalytic site [active] 759350002448 substrate binding site [chemical binding]; other site 759350002449 HRDC domain; Region: HRDC; pfam00570 759350002450 trigger factor; Provisional; Region: tig; PRK01490 759350002451 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 759350002452 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 759350002453 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 759350002454 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 759350002455 putative ion selectivity filter; other site 759350002456 putative pore gating glutamate residue; other site 759350002457 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 759350002458 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 759350002459 dimer interface [polypeptide binding]; other site 759350002460 Clp protease; Region: CLP_protease; pfam00574 759350002461 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 759350002462 oligomer interface [polypeptide binding]; other site 759350002463 active site residues [active] 759350002464 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 759350002465 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 759350002466 oligomer interface [polypeptide binding]; other site 759350002467 active site residues [active] 759350002468 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 759350002469 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 759350002470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350002471 Walker A motif; other site 759350002472 ATP binding site [chemical binding]; other site 759350002473 Walker B motif; other site 759350002474 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 759350002475 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 759350002476 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 759350002477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 759350002478 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 759350002479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 759350002480 L-aspartate oxidase; Provisional; Region: PRK06175 759350002481 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 759350002482 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 759350002483 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 759350002484 DNA protecting protein DprA; Region: dprA; TIGR00732 759350002485 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 759350002486 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 759350002487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350002488 Walker A motif; other site 759350002489 ATP binding site [chemical binding]; other site 759350002490 Walker B motif; other site 759350002491 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 759350002492 hypothetical protein; Provisional; Region: PRK14681 759350002493 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 759350002494 dimer interface [polypeptide binding]; other site 759350002495 pyridoxal binding site [chemical binding]; other site 759350002496 ATP binding site [chemical binding]; other site 759350002497 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 759350002498 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 759350002499 homodimer interface [polypeptide binding]; other site 759350002500 substrate-cofactor binding pocket; other site 759350002501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350002502 catalytic residue [active] 759350002503 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350002504 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759350002505 Walker A/P-loop; other site 759350002506 ATP binding site [chemical binding]; other site 759350002507 Q-loop/lid; other site 759350002508 ABC transporter signature motif; other site 759350002509 Walker B; other site 759350002510 D-loop; other site 759350002511 H-loop/switch region; other site 759350002512 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759350002513 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 759350002514 FtsX-like permease family; Region: FtsX; pfam02687 759350002515 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759350002516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350002517 active site 759350002518 phosphorylation site [posttranslational modification] 759350002519 intermolecular recognition site; other site 759350002520 dimerization interface [polypeptide binding]; other site 759350002521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 759350002522 DNA binding residues [nucleotide binding] 759350002523 dimerization interface [polypeptide binding]; other site 759350002524 Histidine kinase; Region: HisKA_3; pfam07730 759350002525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759350002526 ATP binding site [chemical binding]; other site 759350002527 Mg2+ binding site [ion binding]; other site 759350002528 G-X-G motif; other site 759350002529 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 759350002530 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 759350002531 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 759350002532 GTP-binding protein YchF; Reviewed; Region: PRK09601 759350002533 YchF GTPase; Region: YchF; cd01900 759350002534 G1 box; other site 759350002535 GTP/Mg2+ binding site [chemical binding]; other site 759350002536 Switch I region; other site 759350002537 G2 box; other site 759350002538 Switch II region; other site 759350002539 G3 box; other site 759350002540 G4 box; other site 759350002541 G5 box; other site 759350002542 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 759350002543 Fic family protein [Function unknown]; Region: COG3177 759350002544 Fic/DOC family; Region: Fic; pfam02661 759350002545 hypothetical protein; Provisional; Region: PRK11770 759350002546 Domain of unknown function (DUF307); Region: DUF307; pfam03733 759350002547 Domain of unknown function (DUF307); Region: DUF307; pfam03733 759350002548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759350002549 S-adenosylmethionine binding site [chemical binding]; other site 759350002550 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 759350002551 PemK-like protein; Region: PemK; pfam02452 759350002552 RelB antitoxin; Region: RelB; cl01171 759350002553 HipA-like C-terminal domain; Region: HipA_C; pfam07804 759350002554 H+ Antiporter protein; Region: 2A0121; TIGR00900 759350002555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759350002556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759350002557 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 759350002558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350002559 putative substrate translocation pore; other site 759350002560 FOG: CBS domain [General function prediction only]; Region: COG0517 759350002561 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 759350002562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350002563 H+ Antiporter protein; Region: 2A0121; TIGR00900 759350002564 putative substrate translocation pore; other site 759350002565 Protein kinase domain; Region: Pkinase; pfam00069 759350002566 Catalytic domain of Protein Kinases; Region: PKc; cd00180 759350002567 active site 759350002568 ATP binding site [chemical binding]; other site 759350002569 substrate binding site [chemical binding]; other site 759350002570 activation loop (A-loop); other site 759350002571 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 759350002572 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 759350002573 Short C-terminal domain; Region: SHOCT; pfam09851 759350002574 Excalibur calcium-binding domain; Region: Excalibur; smart00894 759350002575 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 759350002576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759350002577 non-specific DNA binding site [nucleotide binding]; other site 759350002578 salt bridge; other site 759350002579 sequence-specific DNA binding site [nucleotide binding]; other site 759350002580 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 759350002581 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759350002582 catalytic core [active] 759350002583 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 759350002584 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 759350002585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 759350002586 ATP binding site [chemical binding]; other site 759350002587 putative Mg++ binding site [ion binding]; other site 759350002588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759350002589 nucleotide binding region [chemical binding]; other site 759350002590 ATP-binding site [chemical binding]; other site 759350002591 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 759350002592 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 759350002593 active site 759350002594 catalytic site [active] 759350002595 Phosphate transporter family; Region: PHO4; pfam01384 759350002596 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 759350002597 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759350002598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350002599 active site 759350002600 phosphorylation site [posttranslational modification] 759350002601 intermolecular recognition site; other site 759350002602 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 759350002603 DNA binding residues [nucleotide binding] 759350002604 dimerization interface [polypeptide binding]; other site 759350002605 Histidine kinase; Region: HisKA_3; pfam07730 759350002606 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 759350002607 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 759350002608 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 759350002609 Walker A/P-loop; other site 759350002610 ATP binding site [chemical binding]; other site 759350002611 Q-loop/lid; other site 759350002612 ABC transporter signature motif; other site 759350002613 Walker B; other site 759350002614 D-loop; other site 759350002615 H-loop/switch region; other site 759350002616 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 759350002617 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 759350002618 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 759350002619 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 759350002620 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 759350002621 Divergent AAA domain; Region: AAA_4; pfam04326 759350002622 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 759350002623 PIN domain; Region: PIN_3; pfam13470 759350002624 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 759350002625 DNA binding residues [nucleotide binding] 759350002626 N-terminal Mad Homology 1 (MH1) domain; Region: MH1; cl00055 759350002627 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 759350002628 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 759350002629 conserved cys residue [active] 759350002630 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 759350002631 Isochorismatase family; Region: Isochorismatase; pfam00857 759350002632 catalytic triad [active] 759350002633 metal binding site [ion binding]; metal-binding site 759350002634 conserved cis-peptide bond; other site 759350002635 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 759350002636 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 759350002637 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 759350002638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759350002639 salt bridge; other site 759350002640 non-specific DNA binding site [nucleotide binding]; other site 759350002641 sequence-specific DNA binding site [nucleotide binding]; other site 759350002642 xanthine permease; Region: pbuX; TIGR03173 759350002643 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759350002644 active site 759350002645 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 759350002646 Part of AAA domain; Region: AAA_19; pfam13245 759350002647 Family description; Region: UvrD_C_2; pfam13538 759350002648 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 759350002649 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759350002650 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 759350002651 FtsX-like permease family; Region: FtsX; pfam02687 759350002652 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350002653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350002654 Walker A/P-loop; other site 759350002655 ATP binding site [chemical binding]; other site 759350002656 Q-loop/lid; other site 759350002657 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350002658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350002659 ABC transporter signature motif; other site 759350002660 Walker B; other site 759350002661 D-loop; other site 759350002662 H-loop/switch region; other site 759350002663 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 759350002664 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 759350002665 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759350002666 RNA binding surface [nucleotide binding]; other site 759350002667 Peptidase C26; Region: Peptidase_C26; pfam07722 759350002668 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 759350002669 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 759350002670 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 759350002671 active site 759350002672 catalytic motif [active] 759350002673 Zn binding site [ion binding]; other site 759350002674 SdpI/YhfL protein family; Region: SdpI; pfam13630 759350002675 PemK-like protein; Region: PemK; pfam02452 759350002676 RelB antitoxin; Region: RelB; cl01171 759350002677 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 759350002678 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759350002679 catalytic core [active] 759350002680 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 759350002681 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 759350002682 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 759350002683 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 759350002684 motif 1; other site 759350002685 active site 759350002686 motif 2; other site 759350002687 motif 3; other site 759350002688 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 759350002689 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 759350002690 YceG-like family; Region: YceG; pfam02618 759350002691 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 759350002692 dimerization interface [polypeptide binding]; other site 759350002693 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 759350002694 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 759350002695 Tetramer interface [polypeptide binding]; other site 759350002696 active site 759350002697 FMN-binding site [chemical binding]; other site 759350002698 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 759350002699 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 759350002700 magnesium binding site [ion binding]; other site 759350002701 putative shikimate binding site; other site 759350002702 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 759350002703 active site 759350002704 dimer interface [polypeptide binding]; other site 759350002705 metal binding site [ion binding]; metal-binding site 759350002706 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 759350002707 Dehydroquinase class II; Region: DHquinase_II; pfam01220 759350002708 trimer interface [polypeptide binding]; other site 759350002709 active site 759350002710 dimer interface [polypeptide binding]; other site 759350002711 CTP synthetase; Validated; Region: pyrG; PRK05380 759350002712 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 759350002713 Catalytic site [active] 759350002714 active site 759350002715 UTP binding site [chemical binding]; other site 759350002716 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 759350002717 active site 759350002718 putative oxyanion hole; other site 759350002719 catalytic triad [active] 759350002720 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 759350002721 FeS assembly protein SufB; Region: sufB; TIGR01980 759350002722 FeS assembly protein SufD; Region: sufD; TIGR01981 759350002723 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 759350002724 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 759350002725 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 759350002726 Walker A/P-loop; other site 759350002727 ATP binding site [chemical binding]; other site 759350002728 Q-loop/lid; other site 759350002729 ABC transporter signature motif; other site 759350002730 Walker B; other site 759350002731 D-loop; other site 759350002732 H-loop/switch region; other site 759350002733 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 759350002734 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 759350002735 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759350002736 catalytic residue [active] 759350002737 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 759350002738 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 759350002739 trimerization site [polypeptide binding]; other site 759350002740 active site 759350002741 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 759350002742 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 759350002743 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 759350002744 ligand binding site; other site 759350002745 oligomer interface; other site 759350002746 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 759350002747 dimer interface [polypeptide binding]; other site 759350002748 N-terminal domain interface [polypeptide binding]; other site 759350002749 sulfate 1 binding site; other site 759350002750 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 759350002751 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 759350002752 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 759350002753 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 759350002754 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 759350002755 nucleotide binding site/active site [active] 759350002756 HIT family signature motif; other site 759350002757 catalytic residue [active] 759350002758 PhoH-like protein; Region: PhoH; pfam02562 759350002759 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 759350002760 metal-binding heat shock protein; Provisional; Region: PRK00016 759350002761 Domain of unknown function DUF21; Region: DUF21; pfam01595 759350002762 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 759350002763 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 759350002764 Transporter associated domain; Region: CorC_HlyC; smart01091 759350002765 GTPase Era; Reviewed; Region: era; PRK00089 759350002766 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 759350002767 G1 box; other site 759350002768 GTP/Mg2+ binding site [chemical binding]; other site 759350002769 Switch I region; other site 759350002770 G2 box; other site 759350002771 Switch II region; other site 759350002772 G3 box; other site 759350002773 G4 box; other site 759350002774 G5 box; other site 759350002775 KH domain; Region: KH_2; pfam07650 759350002776 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 759350002777 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 759350002778 acyl-activating enzyme (AAE) consensus motif; other site 759350002779 putative AMP binding site [chemical binding]; other site 759350002780 putative active site [active] 759350002781 putative CoA binding site [chemical binding]; other site 759350002782 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 759350002783 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 759350002784 NAD binding site [chemical binding]; other site 759350002785 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 759350002786 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 759350002787 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 759350002788 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 759350002789 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 759350002790 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 759350002791 5S rRNA interface [nucleotide binding]; other site 759350002792 CTC domain interface [polypeptide binding]; other site 759350002793 L16 interface [polypeptide binding]; other site 759350002794 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 759350002795 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 759350002796 homodimer interface [polypeptide binding]; other site 759350002797 substrate-cofactor binding pocket; other site 759350002798 catalytic residue [active] 759350002799 UPF0126 domain; Region: UPF0126; pfam03458 759350002800 Predicted membrane protein [Function unknown]; Region: COG2860 759350002801 UPF0126 domain; Region: UPF0126; pfam03458 759350002802 Transposase, Mutator family; Region: Transposase_mut; pfam00872 759350002803 MULE transposase domain; Region: MULE; pfam10551 759350002804 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 759350002805 GTP-binding protein LepA; Provisional; Region: PRK05433 759350002806 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 759350002807 G1 box; other site 759350002808 putative GEF interaction site [polypeptide binding]; other site 759350002809 GTP/Mg2+ binding site [chemical binding]; other site 759350002810 Switch I region; other site 759350002811 G2 box; other site 759350002812 G3 box; other site 759350002813 Switch II region; other site 759350002814 G4 box; other site 759350002815 G5 box; other site 759350002816 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 759350002817 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 759350002818 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 759350002819 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 759350002820 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759350002821 FeS/SAM binding site; other site 759350002822 HemN C-terminal domain; Region: HemN_C; pfam06969 759350002823 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350002824 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350002825 DNA binding site [nucleotide binding] 759350002826 domain linker motif; other site 759350002827 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350002828 dimerization interface [polypeptide binding]; other site 759350002829 ligand binding site [chemical binding]; other site 759350002830 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 759350002831 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 759350002832 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 759350002833 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350002834 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350002835 DNA binding site [nucleotide binding] 759350002836 domain linker motif; other site 759350002837 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 759350002838 ligand binding site [chemical binding]; other site 759350002839 dimerization interface (open form) [polypeptide binding]; other site 759350002840 dimerization interface (closed form) [polypeptide binding]; other site 759350002841 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 759350002842 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 759350002843 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 759350002844 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350002845 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350002846 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 759350002847 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 759350002848 active site 759350002849 dimer interface [polypeptide binding]; other site 759350002850 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 759350002851 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 759350002852 active site 759350002853 FMN binding site [chemical binding]; other site 759350002854 substrate binding site [chemical binding]; other site 759350002855 3Fe-4S cluster binding site [ion binding]; other site 759350002856 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 759350002857 domain interface; other site 759350002858 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 759350002859 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759350002860 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 759350002861 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 759350002862 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 759350002863 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 759350002864 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 759350002865 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 759350002866 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 759350002867 Walker A/P-loop; other site 759350002868 ATP binding site [chemical binding]; other site 759350002869 Q-loop/lid; other site 759350002870 ABC transporter signature motif; other site 759350002871 Walker B; other site 759350002872 D-loop; other site 759350002873 H-loop/switch region; other site 759350002874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759350002875 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 759350002876 active site 759350002877 motif I; other site 759350002878 motif II; other site 759350002879 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 759350002880 H+ Antiporter protein; Region: 2A0121; TIGR00900 759350002881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350002882 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759350002883 putative substrate translocation pore; other site 759350002884 transposase/IS protein; Provisional; Region: PRK09183 759350002885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350002886 Walker A motif; other site 759350002887 ATP binding site [chemical binding]; other site 759350002888 Walker B motif; other site 759350002889 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 759350002890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 759350002891 DNA-binding interface [nucleotide binding]; DNA binding site 759350002892 Integrase core domain; Region: rve; pfam00665 759350002893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 759350002894 Integrase core domain; Region: rve; pfam00665 759350002895 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759350002896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350002897 Walker A motif; other site 759350002898 ATP binding site [chemical binding]; other site 759350002899 Walker B motif; other site 759350002900 arginine finger; other site 759350002901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 759350002902 Transposase; Region: DDE_Tnp_ISL3; pfam01610 759350002903 Transposase, Mutator family; Region: Transposase_mut; pfam00872 759350002904 MULE transposase domain; Region: MULE; pfam10551 759350002905 AAA domain; Region: AAA_13; pfam13166 759350002906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350002907 Walker A/P-loop; other site 759350002908 ATP binding site [chemical binding]; other site 759350002909 Q-loop/lid; other site 759350002910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350002911 ABC transporter signature motif; other site 759350002912 Walker B; other site 759350002913 D-loop; other site 759350002914 H-loop/switch region; other site 759350002915 Restriction endonuclease [Defense mechanisms]; Region: COG3587 759350002916 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 759350002917 ATP binding site [chemical binding]; other site 759350002918 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 759350002919 DNA methylase; Region: N6_N4_Mtase; pfam01555 759350002920 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 759350002921 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 759350002922 putative active site [active] 759350002923 catalytic site [active] 759350002924 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 759350002925 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759350002926 ATP binding site [chemical binding]; other site 759350002927 putative Mg++ binding site [ion binding]; other site 759350002928 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759350002929 nucleotide binding region [chemical binding]; other site 759350002930 ATP-binding site [chemical binding]; other site 759350002931 Uncharacterized conserved protein [Function unknown]; Region: COG1479 759350002932 Protein of unknown function DUF262; Region: DUF262; pfam03235 759350002933 Protein of unknown function DUF262; Region: DUF262; pfam03235 759350002934 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 759350002935 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 759350002936 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 759350002937 Predicted permeases [General function prediction only]; Region: RarD; COG2962 759350002938 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 759350002939 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 759350002940 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 759350002941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759350002942 S-adenosylmethionine binding site [chemical binding]; other site 759350002943 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759350002944 catalytic core [active] 759350002945 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 759350002946 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 759350002947 THF binding site; other site 759350002948 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 759350002949 substrate binding site [chemical binding]; other site 759350002950 THF binding site; other site 759350002951 zinc-binding site [ion binding]; other site 759350002952 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 759350002953 FAD binding site [chemical binding]; other site 759350002954 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 759350002955 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 759350002956 active site 759350002957 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 759350002958 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 759350002959 metal binding triad; other site 759350002960 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 759350002961 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 759350002962 metal binding triad; other site 759350002963 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 759350002964 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 759350002965 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 759350002966 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 759350002967 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 759350002968 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 759350002969 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 759350002970 dihydroorotase; Validated; Region: pyrC; PRK09357 759350002971 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 759350002972 active site 759350002973 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 759350002974 active site 759350002975 dimer interface [polypeptide binding]; other site 759350002976 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 759350002977 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 759350002978 FAD binding pocket [chemical binding]; other site 759350002979 FAD binding motif [chemical binding]; other site 759350002980 phosphate binding motif [ion binding]; other site 759350002981 beta-alpha-beta structure motif; other site 759350002982 NAD binding pocket [chemical binding]; other site 759350002983 Iron coordination center [ion binding]; other site 759350002984 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 759350002985 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 759350002986 heterodimer interface [polypeptide binding]; other site 759350002987 active site 759350002988 FMN binding site [chemical binding]; other site 759350002989 homodimer interface [polypeptide binding]; other site 759350002990 substrate binding site [chemical binding]; other site 759350002991 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759350002992 active site 759350002993 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 759350002994 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759350002995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759350002996 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 759350002997 dimerization interface [polypeptide binding]; other site 759350002998 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 759350002999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759350003000 motif II; other site 759350003001 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 759350003002 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 759350003003 aspartate aminotransferase; Provisional; Region: PRK06836 759350003004 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759350003005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350003006 homodimer interface [polypeptide binding]; other site 759350003007 catalytic residue [active] 759350003008 Uncharacterized conserved protein [Function unknown]; Region: COG3189 759350003009 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 759350003010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350003011 H-loop/switch region; other site 759350003012 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 759350003013 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 759350003014 Catalytic site [active] 759350003015 S-methylmethionine transporter; Provisional; Region: PRK11387 759350003016 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 759350003017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350003018 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 759350003019 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 759350003020 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 759350003021 nudix motif; other site 759350003022 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 759350003023 Predicted amidohydrolase [General function prediction only]; Region: COG0388 759350003024 HipA N-terminal domain; Region: Couple_hipA; cl11853 759350003025 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 759350003026 FIC domain binding interface [polypeptide binding]; other site 759350003027 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 759350003028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350003029 Walker A/P-loop; other site 759350003030 ATP binding site [chemical binding]; other site 759350003031 Q-loop/lid; other site 759350003032 ABC transporter signature motif; other site 759350003033 Walker B; other site 759350003034 D-loop; other site 759350003035 H-loop/switch region; other site 759350003036 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 759350003037 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 759350003038 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 759350003039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 759350003040 RelB antitoxin; Region: RelB; cl01171 759350003041 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759350003042 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 759350003043 FtsX-like permease family; Region: FtsX; pfam02687 759350003044 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350003045 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759350003046 Walker A/P-loop; other site 759350003047 ATP binding site [chemical binding]; other site 759350003048 Q-loop/lid; other site 759350003049 ABC transporter signature motif; other site 759350003050 Walker B; other site 759350003051 D-loop; other site 759350003052 H-loop/switch region; other site 759350003053 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 759350003054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759350003055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350003056 active site 759350003057 phosphorylation site [posttranslational modification] 759350003058 intermolecular recognition site; other site 759350003059 dimerization interface [polypeptide binding]; other site 759350003060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 759350003061 DNA binding residues [nucleotide binding] 759350003062 dimerization interface [polypeptide binding]; other site 759350003063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 759350003064 Histidine kinase; Region: HisKA_3; pfam07730 759350003065 Abi-like protein; Region: Abi_2; cl01988 759350003066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759350003067 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 759350003068 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 759350003069 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 759350003070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759350003071 Coenzyme A binding pocket [chemical binding]; other site 759350003072 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 759350003073 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 759350003074 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 759350003075 VanZ like family; Region: VanZ; pfam04892 759350003076 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759350003077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350003078 S-methylmethionine transporter; Provisional; Region: PRK11387 759350003079 endonuclease IV; Provisional; Region: PRK01060 759350003080 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 759350003081 AP (apurinic/apyrimidinic) site pocket; other site 759350003082 DNA interaction; other site 759350003083 Metal-binding active site; metal-binding site 759350003084 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 759350003085 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 759350003086 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 759350003087 active site 759350003088 ribulose/triose binding site [chemical binding]; other site 759350003089 phosphate binding site [ion binding]; other site 759350003090 substrate (anthranilate) binding pocket [chemical binding]; other site 759350003091 product (indole) binding pocket [chemical binding]; other site 759350003092 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 759350003093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350003094 catalytic residue [active] 759350003095 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 759350003096 substrate binding site [chemical binding]; other site 759350003097 active site 759350003098 catalytic residues [active] 759350003099 heterodimer interface [polypeptide binding]; other site 759350003100 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 759350003101 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 759350003102 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 759350003103 substrate binding site [chemical binding]; other site 759350003104 hexamer interface [polypeptide binding]; other site 759350003105 metal binding site [ion binding]; metal-binding site 759350003106 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 759350003107 homodimer interface [polypeptide binding]; other site 759350003108 putative metal binding site [ion binding]; other site 759350003109 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 759350003110 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 759350003111 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 759350003112 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 759350003113 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 759350003114 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 759350003115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 759350003116 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 759350003117 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 759350003118 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 759350003119 phosphopeptide binding site; other site 759350003120 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 759350003121 DNA binding residues [nucleotide binding] 759350003122 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 759350003123 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 759350003124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759350003125 motif II; other site 759350003126 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 759350003127 DEAD-like helicases superfamily; Region: DEXDc; smart00487 759350003128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759350003129 ATP binding site [chemical binding]; other site 759350003130 putative Mg++ binding site [ion binding]; other site 759350003131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759350003132 nucleotide binding region [chemical binding]; other site 759350003133 ATP-binding site [chemical binding]; other site 759350003134 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 759350003135 Predicted transcriptional regulator [Transcription]; Region: COG2378 759350003136 WYL domain; Region: WYL; pfam13280 759350003137 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759350003138 active site 759350003139 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 759350003140 AAA domain; Region: AAA_17; pfam13207 759350003141 Cytidylate kinase; Region: Cytidylate_kin; pfam02224 759350003142 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 759350003143 G1 box; other site 759350003144 GTP/Mg2+ binding site [chemical binding]; other site 759350003145 Switch I region; other site 759350003146 G2 box; other site 759350003147 Switch II region; other site 759350003148 G3 box; other site 759350003149 G4 box; other site 759350003150 G5 box; other site 759350003151 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 759350003152 G1 box; other site 759350003153 GTP/Mg2+ binding site [chemical binding]; other site 759350003154 Switch I region; other site 759350003155 G2 box; other site 759350003156 G3 box; other site 759350003157 Switch II region; other site 759350003158 G4 box; other site 759350003159 G5 box; other site 759350003160 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 759350003161 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759350003162 RNA binding surface [nucleotide binding]; other site 759350003163 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 759350003164 active site 759350003165 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 759350003166 amphipathic channel; other site 759350003167 Asn-Pro-Ala signature motifs; other site 759350003168 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 759350003169 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 759350003170 purine monophosphate binding site [chemical binding]; other site 759350003171 dimer interface [polypeptide binding]; other site 759350003172 putative catalytic residues [active] 759350003173 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 759350003174 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 759350003175 CoA binding domain; Region: CoA_binding; smart00881 759350003176 CoA-ligase; Region: Ligase_CoA; pfam00549 759350003177 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 759350003178 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 759350003179 CoA-ligase; Region: Ligase_CoA; pfam00549 759350003180 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759350003181 active site 759350003182 Preprotein translocase subunit; Region: YajC; pfam02699 759350003183 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 759350003184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350003185 Walker A motif; other site 759350003186 ATP binding site [chemical binding]; other site 759350003187 Walker B motif; other site 759350003188 arginine finger; other site 759350003189 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 759350003190 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 759350003191 RuvA N terminal domain; Region: RuvA_N; pfam01330 759350003192 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 759350003193 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 759350003194 active site 759350003195 putative DNA-binding cleft [nucleotide binding]; other site 759350003196 dimer interface [polypeptide binding]; other site 759350003197 hypothetical protein; Validated; Region: PRK00110 759350003198 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 759350003199 nucleotide binding site/active site [active] 759350003200 HIT family signature motif; other site 759350003201 catalytic residue [active] 759350003202 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 759350003203 thiS-thiF/thiG interaction site; other site 759350003204 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 759350003205 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 759350003206 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 759350003207 active site 759350003208 dimer interface [polypeptide binding]; other site 759350003209 motif 1; other site 759350003210 motif 2; other site 759350003211 motif 3; other site 759350003212 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 759350003213 anticodon binding site; other site 759350003214 PAC2 family; Region: PAC2; pfam09754 759350003215 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 759350003216 Fructosamine kinase; Region: Fructosamin_kin; cl17579 759350003217 Phosphotransferase enzyme family; Region: APH; pfam01636 759350003218 chaperone protein DnaJ; Provisional; Region: PRK14278 759350003219 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 759350003220 HSP70 interaction site [polypeptide binding]; other site 759350003221 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 759350003222 Zn binding sites [ion binding]; other site 759350003223 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 759350003224 dimer interface [polypeptide binding]; other site 759350003225 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 759350003226 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 759350003227 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 759350003228 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 759350003229 TPP-binding site [chemical binding]; other site 759350003230 dimer interface [polypeptide binding]; other site 759350003231 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 759350003232 PYR/PP interface [polypeptide binding]; other site 759350003233 dimer interface [polypeptide binding]; other site 759350003234 TPP binding site [chemical binding]; other site 759350003235 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 759350003236 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 759350003237 putative active site [active] 759350003238 transaldolase; Provisional; Region: PRK03903 759350003239 catalytic residue [active] 759350003240 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 759350003241 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 759350003242 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759350003243 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 759350003244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759350003245 non-specific DNA binding site [nucleotide binding]; other site 759350003246 salt bridge; other site 759350003247 sequence-specific DNA binding site [nucleotide binding]; other site 759350003248 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759350003249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350003250 homodimer interface [polypeptide binding]; other site 759350003251 catalytic residue [active] 759350003252 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 759350003253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759350003254 active site 759350003255 motif I; other site 759350003256 motif II; other site 759350003257 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 759350003258 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 759350003259 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759350003260 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 759350003261 NAD binding site [chemical binding]; other site 759350003262 dimer interface [polypeptide binding]; other site 759350003263 substrate binding site [chemical binding]; other site 759350003264 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 759350003265 triosephosphate isomerase; Provisional; Region: PRK14567 759350003266 substrate binding site [chemical binding]; other site 759350003267 dimer interface [polypeptide binding]; other site 759350003268 catalytic triad [active] 759350003269 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 759350003270 Phosphoglycerate kinase; Region: PGK; pfam00162 759350003271 substrate binding site [chemical binding]; other site 759350003272 hinge regions; other site 759350003273 ADP binding site [chemical binding]; other site 759350003274 catalytic site [active] 759350003275 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 759350003276 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 759350003277 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 759350003278 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 759350003279 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 759350003280 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 759350003281 shikimate binding site; other site 759350003282 NAD(P) binding site [chemical binding]; other site 759350003283 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 759350003284 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 759350003285 GIY-YIG motif/motif A; other site 759350003286 active site 759350003287 catalytic site [active] 759350003288 putative DNA binding site [nucleotide binding]; other site 759350003289 metal binding site [ion binding]; metal-binding site 759350003290 UvrB/uvrC motif; Region: UVR; pfam02151 759350003291 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 759350003292 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 759350003293 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 759350003294 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 759350003295 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 759350003296 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 759350003297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 759350003298 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 759350003299 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 759350003300 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 759350003301 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 759350003302 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 759350003303 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759350003304 FtsX-like permease family; Region: FtsX; pfam02687 759350003305 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350003306 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759350003307 Walker A/P-loop; other site 759350003308 ATP binding site [chemical binding]; other site 759350003309 Q-loop/lid; other site 759350003310 ABC transporter signature motif; other site 759350003311 Walker B; other site 759350003312 D-loop; other site 759350003313 H-loop/switch region; other site 759350003314 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 759350003315 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759350003316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350003317 active site 759350003318 phosphorylation site [posttranslational modification] 759350003319 intermolecular recognition site; other site 759350003320 dimerization interface [polypeptide binding]; other site 759350003321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759350003322 DNA binding site [nucleotide binding] 759350003323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759350003324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759350003325 dimer interface [polypeptide binding]; other site 759350003326 phosphorylation site [posttranslational modification] 759350003327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759350003328 ATP binding site [chemical binding]; other site 759350003329 Mg2+ binding site [ion binding]; other site 759350003330 G-X-G motif; other site 759350003331 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 759350003332 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 759350003333 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 759350003334 classical (c) SDRs; Region: SDR_c; cd05233 759350003335 NAD(P) binding site [chemical binding]; other site 759350003336 active site 759350003337 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 759350003338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350003339 Walker A/P-loop; other site 759350003340 ATP binding site [chemical binding]; other site 759350003341 Q-loop/lid; other site 759350003342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759350003343 ABC transporter signature motif; other site 759350003344 Walker B; other site 759350003345 D-loop; other site 759350003346 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759350003347 Protein of unknown function (DUF969); Region: DUF969; cl01573 759350003348 Predicted membrane protein [Function unknown]; Region: COG3817 759350003349 Protein of unknown function (DUF979); Region: DUF979; pfam06166 759350003350 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 759350003351 putative substrate binding pocket [chemical binding]; other site 759350003352 AC domain interface; other site 759350003353 catalytic triad [active] 759350003354 AB domain interface; other site 759350003355 interchain disulfide; other site 759350003356 anthranilate synthase component I; Provisional; Region: PRK13571 759350003357 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 759350003358 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 759350003359 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 759350003360 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 759350003361 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 759350003362 substrate binding site [chemical binding]; other site 759350003363 glutamase interaction surface [polypeptide binding]; other site 759350003364 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 759350003365 intracellular protease, PfpI family; Region: PfpI; TIGR01382 759350003366 proposed catalytic triad [active] 759350003367 conserved cys residue [active] 759350003368 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 759350003369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759350003370 FeS/SAM binding site; other site 759350003371 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 759350003372 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 759350003373 ribosome recycling factor; Reviewed; Region: frr; PRK00083 759350003374 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 759350003375 hinge region; other site 759350003376 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 759350003377 putative nucleotide binding site [chemical binding]; other site 759350003378 uridine monophosphate binding site [chemical binding]; other site 759350003379 homohexameric interface [polypeptide binding]; other site 759350003380 elongation factor Ts; Provisional; Region: tsf; PRK09377 759350003381 Elongation factor TS; Region: EF_TS; pfam00889 759350003382 Elongation factor TS; Region: EF_TS; pfam00889 759350003383 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 759350003384 rRNA interaction site [nucleotide binding]; other site 759350003385 S8 interaction site; other site 759350003386 putative laminin-1 binding site; other site 759350003387 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 759350003388 active site 759350003389 catalytic residues [active] 759350003390 metal binding site [ion binding]; metal-binding site 759350003391 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 759350003392 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 759350003393 acyl-activating enzyme (AAE) consensus motif; other site 759350003394 putative AMP binding site [chemical binding]; other site 759350003395 putative active site [active] 759350003396 putative CoA binding site [chemical binding]; other site 759350003397 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 759350003398 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 759350003399 active site 759350003400 isocitrate dehydrogenase; Validated; Region: PRK08299 759350003401 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759350003402 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759350003403 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 759350003404 Peptidase family M23; Region: Peptidase_M23; pfam01551 759350003405 MULE transposase domain; Region: MULE; pfam10551 759350003406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759350003407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350003408 active site 759350003409 phosphorylation site [posttranslational modification] 759350003410 intermolecular recognition site; other site 759350003411 dimerization interface [polypeptide binding]; other site 759350003412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 759350003413 DNA binding residues [nucleotide binding] 759350003414 dimerization interface [polypeptide binding]; other site 759350003415 Histidine kinase; Region: HisKA_3; pfam07730 759350003416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759350003417 ATP binding site [chemical binding]; other site 759350003418 Mg2+ binding site [ion binding]; other site 759350003419 G-X-G motif; other site 759350003420 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 759350003421 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 759350003422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350003423 Walker A/P-loop; other site 759350003424 ATP binding site [chemical binding]; other site 759350003425 Q-loop/lid; other site 759350003426 ABC transporter signature motif; other site 759350003427 Walker B; other site 759350003428 D-loop; other site 759350003429 H-loop/switch region; other site 759350003430 Fic/DOC family; Region: Fic; cl00960 759350003431 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 759350003432 UGMP family protein; Validated; Region: PRK09604 759350003433 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 759350003434 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 759350003435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759350003436 Coenzyme A binding pocket [chemical binding]; other site 759350003437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759350003438 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 759350003439 Glycoprotease family; Region: Peptidase_M22; pfam00814 759350003440 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 759350003441 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 759350003442 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 759350003443 Competence protein; Region: Competence; pfam03772 759350003444 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 759350003445 Helix-hairpin-helix motif; Region: HHH; pfam00633 759350003446 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 759350003447 aminoacyl-tRNA ligase; Region: PLN02563 759350003448 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759350003449 active site 759350003450 HIGH motif; other site 759350003451 nucleotide binding site [chemical binding]; other site 759350003452 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759350003453 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 759350003454 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759350003455 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759350003456 active site 759350003457 KMSKS motif; other site 759350003458 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 759350003459 tRNA binding surface [nucleotide binding]; other site 759350003460 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 759350003461 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759350003462 substrate binding pocket [chemical binding]; other site 759350003463 membrane-bound complex binding site; other site 759350003464 hinge residues; other site 759350003465 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 759350003466 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 759350003467 Cl binding site [ion binding]; other site 759350003468 oligomer interface [polypeptide binding]; other site 759350003469 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759350003470 catalytic core [active] 759350003471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 759350003472 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 759350003473 EamA-like transporter family; Region: EamA; pfam00892 759350003474 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 759350003475 EamA-like transporter family; Region: EamA; pfam00892 759350003476 Integrase core domain; Region: rve; pfam00665 759350003477 Integrase core domain; Region: rve_2; pfam13333 759350003478 Helix-turn-helix domain; Region: HTH_28; pfam13518 759350003479 Fic family protein [Function unknown]; Region: COG3177 759350003480 Fic/DOC family; Region: Fic; pfam02661 759350003481 HipA-like C-terminal domain; Region: HipA_C; pfam07804 759350003482 Abi-like protein; Region: Abi_2; cl01988 759350003483 Integrase core domain; Region: rve; pfam00665 759350003484 Integrase core domain; Region: rve_2; pfam13333 759350003485 Protein of unknown function (DUF2699); Region: DUF2699; pfam10919 759350003486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350003487 putative substrate translocation pore; other site 759350003488 H+ Antiporter protein; Region: 2A0121; TIGR00900 759350003489 Integrase core domain; Region: rve; pfam00665 759350003490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 759350003491 Helix-turn-helix domain; Region: HTH_28; pfam13518 759350003492 Winged helix-turn helix; Region: HTH_29; pfam13551 759350003493 putative transposase OrfB; Reviewed; Region: PHA02517 759350003494 HTH-like domain; Region: HTH_21; pfam13276 759350003495 Integrase core domain; Region: rve; pfam00665 759350003496 Integrase core domain; Region: rve_2; pfam13333 759350003497 Fic/DOC family; Region: Fic; cl00960 759350003498 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 759350003499 FIC domain binding interface [polypeptide binding]; other site 759350003500 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 759350003501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759350003502 non-specific DNA binding site [nucleotide binding]; other site 759350003503 salt bridge; other site 759350003504 sequence-specific DNA binding site [nucleotide binding]; other site 759350003505 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 759350003506 active site 759350003507 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 759350003508 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759350003509 Zn2+ binding site [ion binding]; other site 759350003510 Mg2+ binding site [ion binding]; other site 759350003511 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 759350003512 synthetase active site [active] 759350003513 NTP binding site [chemical binding]; other site 759350003514 metal binding site [ion binding]; metal-binding site 759350003515 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 759350003516 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 759350003517 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 759350003518 trimer interface [polypeptide binding]; other site 759350003519 active site 759350003520 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 759350003521 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 759350003522 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 759350003523 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 759350003524 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 759350003525 CAP-like domain; other site 759350003526 active site 759350003527 primary dimer interface [polypeptide binding]; other site 759350003528 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759350003529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759350003530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 759350003531 active site 759350003532 phosphorylation site [posttranslational modification] 759350003533 intermolecular recognition site; other site 759350003534 dimerization interface [polypeptide binding]; other site 759350003535 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 759350003536 DNA binding site [nucleotide binding] 759350003537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759350003538 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 759350003539 ATP binding site [chemical binding]; other site 759350003540 putative Mg++ binding site [ion binding]; other site 759350003541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759350003542 nucleotide binding region [chemical binding]; other site 759350003543 ATP-binding site [chemical binding]; other site 759350003544 DEAD/H associated; Region: DEAD_assoc; pfam08494 759350003545 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 759350003546 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 759350003547 substrate binding site [chemical binding]; other site 759350003548 dimer interface [polypeptide binding]; other site 759350003549 ATP binding site [chemical binding]; other site 759350003550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350003551 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759350003552 putative substrate translocation pore; other site 759350003553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759350003554 Mg2+ binding site [ion binding]; other site 759350003555 G-X-G motif; other site 759350003556 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 759350003557 anchoring element; other site 759350003558 dimer interface [polypeptide binding]; other site 759350003559 ATP binding site [chemical binding]; other site 759350003560 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 759350003561 active site 759350003562 metal binding site [ion binding]; metal-binding site 759350003563 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 759350003564 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 759350003565 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 759350003566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759350003567 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 759350003568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759350003569 DNA binding residues [nucleotide binding] 759350003570 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 759350003571 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 759350003572 substrate binding pocket [chemical binding]; other site 759350003573 chain length determination region; other site 759350003574 substrate-Mg2+ binding site; other site 759350003575 catalytic residues [active] 759350003576 aspartate-rich region 1; other site 759350003577 active site lid residues [active] 759350003578 aspartate-rich region 2; other site 759350003579 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 759350003580 Catalytic domain of Protein Kinases; Region: PKc; cd00180 759350003581 active site 759350003582 ATP binding site [chemical binding]; other site 759350003583 substrate binding site [chemical binding]; other site 759350003584 activation loop (A-loop); other site 759350003585 PASTA domain; Region: PASTA; pfam03793 759350003586 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 759350003587 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 759350003588 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 759350003589 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 759350003590 putative acyl-acceptor binding pocket; other site 759350003591 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 759350003592 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 759350003593 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 759350003594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 759350003595 Transposase; Region: DDE_Tnp_ISL3; pfam01610 759350003596 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 759350003597 DEAD/DEAH box helicase; Region: DEAD; pfam00270 759350003598 ATP binding site [chemical binding]; other site 759350003599 putative Mg++ binding site [ion binding]; other site 759350003600 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 759350003601 SEC-C motif; Region: SEC-C; pfam02810 759350003602 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 759350003603 30S subunit binding site; other site 759350003604 RecX family; Region: RecX; pfam02631 759350003605 recombinase A; Provisional; Region: recA; PRK09354 759350003606 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 759350003607 hexamer interface [polypeptide binding]; other site 759350003608 Walker A motif; other site 759350003609 ATP binding site [chemical binding]; other site 759350003610 Walker B motif; other site 759350003611 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 759350003612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759350003613 sequence-specific DNA binding site [nucleotide binding]; other site 759350003614 salt bridge; other site 759350003615 Competence-damaged protein; Region: CinA; pfam02464 759350003616 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 759350003617 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 759350003618 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 759350003619 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 759350003620 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 759350003621 Fic/DOC family; Region: Fic; cl00960 759350003622 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 759350003623 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 759350003624 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 759350003625 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 759350003626 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759350003627 FeS/SAM binding site; other site 759350003628 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 759350003629 synthetase active site [active] 759350003630 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 759350003631 NTP binding site [chemical binding]; other site 759350003632 metal binding site [ion binding]; metal-binding site 759350003633 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759350003634 EamA-like transporter family; Region: EamA; pfam00892 759350003635 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 759350003636 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 759350003637 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 759350003638 DNA binding residues [nucleotide binding] 759350003639 dimerization interface [polypeptide binding]; other site 759350003640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759350003641 Coenzyme A binding pocket [chemical binding]; other site 759350003642 Protein of unknown function DUF262; Region: DUF262; pfam03235 759350003643 Uncharacterized conserved protein [Function unknown]; Region: COG1479 759350003644 Protein of unknown function DUF262; Region: DUF262; pfam03235 759350003645 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 759350003646 RelB antitoxin; Region: RelB; cl01171 759350003647 aconitate hydratase; Validated; Region: PRK09277 759350003648 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 759350003649 substrate binding site [chemical binding]; other site 759350003650 ligand binding site [chemical binding]; other site 759350003651 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 759350003652 substrate binding site [chemical binding]; other site 759350003653 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 759350003654 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 759350003655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759350003656 motif II; other site 759350003657 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759350003658 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 759350003659 TRAM domain; Region: TRAM; cl01282 759350003660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 759350003661 S-adenosylmethionine binding site [chemical binding]; other site 759350003662 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 759350003663 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 759350003664 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 759350003665 putative active site [active] 759350003666 putative catalytic site [active] 759350003667 putative DNA binding site [nucleotide binding]; other site 759350003668 putative phosphate binding site [ion binding]; other site 759350003669 metal binding site A [ion binding]; metal-binding site 759350003670 putative AP binding site [nucleotide binding]; other site 759350003671 putative metal binding site B [ion binding]; other site 759350003672 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759350003673 AAA domain; Region: AAA_21; pfam13304 759350003674 Walker A/P-loop; other site 759350003675 ATP binding site [chemical binding]; other site 759350003676 Q-loop/lid; other site 759350003677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759350003678 ABC transporter signature motif; other site 759350003679 Walker B; other site 759350003680 D-loop; other site 759350003681 H-loop/switch region; other site 759350003682 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759350003683 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759350003684 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759350003685 Walker A/P-loop; other site 759350003686 ATP binding site [chemical binding]; other site 759350003687 Q-loop/lid; other site 759350003688 ABC transporter signature motif; other site 759350003689 Walker B; other site 759350003690 D-loop; other site 759350003691 H-loop/switch region; other site 759350003692 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759350003693 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759350003694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350003695 dimer interface [polypeptide binding]; other site 759350003696 conserved gate region; other site 759350003697 putative PBP binding loops; other site 759350003698 ABC-ATPase subunit interface; other site 759350003699 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759350003700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350003701 dimer interface [polypeptide binding]; other site 759350003702 conserved gate region; other site 759350003703 putative PBP binding loops; other site 759350003704 ABC-ATPase subunit interface; other site 759350003705 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 759350003706 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 759350003707 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 759350003708 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759350003709 active site 759350003710 DNA binding site [nucleotide binding] 759350003711 Int/Topo IB signature motif; other site 759350003712 Prephenate dehydrogenase; Region: PDH; pfam02153 759350003713 prephenate dehydrogenase; Validated; Region: PRK08507 759350003714 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 759350003715 Prephenate dehydratase; Region: PDT; pfam00800 759350003716 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 759350003717 putative L-Phe binding site [chemical binding]; other site 759350003718 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 759350003719 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 759350003720 G1 box; other site 759350003721 putative GEF interaction site [polypeptide binding]; other site 759350003722 GTP/Mg2+ binding site [chemical binding]; other site 759350003723 Switch I region; other site 759350003724 G2 box; other site 759350003725 G3 box; other site 759350003726 Switch II region; other site 759350003727 G4 box; other site 759350003728 G5 box; other site 759350003729 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 759350003730 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 759350003731 Predicted transcriptional regulators [Transcription]; Region: COG1695 759350003732 Transcriptional regulator PadR-like family; Region: PadR; cl17335 759350003733 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350003734 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759350003735 Walker A/P-loop; other site 759350003736 ATP binding site [chemical binding]; other site 759350003737 Q-loop/lid; other site 759350003738 ABC transporter signature motif; other site 759350003739 Walker B; other site 759350003740 D-loop; other site 759350003741 H-loop/switch region; other site 759350003742 benzoate transport; Region: 2A0115; TIGR00895 759350003743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350003744 putative substrate translocation pore; other site 759350003745 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 759350003746 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 759350003747 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759350003748 catalytic residue [active] 759350003749 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 759350003750 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 759350003751 dimerization interface [polypeptide binding]; other site 759350003752 active site 759350003753 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 759350003754 L-aspartate oxidase; Provisional; Region: PRK06175 759350003755 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 759350003756 quinolinate synthetase; Provisional; Region: PRK09375 759350003757 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 759350003758 nudix motif; other site 759350003759 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 759350003760 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 759350003761 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 759350003762 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 759350003763 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759350003764 P-loop; other site 759350003765 Magnesium ion binding site [ion binding]; other site 759350003766 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759350003767 Magnesium ion binding site [ion binding]; other site 759350003768 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 759350003769 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 759350003770 active site 759350003771 Int/Topo IB signature motif; other site 759350003772 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 759350003773 23S rRNA binding site [nucleotide binding]; other site 759350003774 L21 binding site [polypeptide binding]; other site 759350003775 L13 binding site [polypeptide binding]; other site 759350003776 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 759350003777 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 759350003778 Thiamine pyrophosphokinase; Region: TPK; cd07995 759350003779 dimerization interface [polypeptide binding]; other site 759350003780 active site 759350003781 thiamine binding site [chemical binding]; other site 759350003782 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 759350003783 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 759350003784 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 759350003785 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 759350003786 putative deacylase active site [active] 759350003787 Helix-turn-helix domain; Region: HTH_36; pfam13730 759350003788 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 759350003789 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 759350003790 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 759350003791 Walker A motif; other site 759350003792 ATP binding site [chemical binding]; other site 759350003793 Walker B motif; other site 759350003794 Integrase core domain; Region: rve; pfam00665 759350003795 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 759350003796 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 759350003797 G1 box; other site 759350003798 putative GEF interaction site [polypeptide binding]; other site 759350003799 GTP/Mg2+ binding site [chemical binding]; other site 759350003800 Switch I region; other site 759350003801 G2 box; other site 759350003802 G3 box; other site 759350003803 Switch II region; other site 759350003804 G4 box; other site 759350003805 G5 box; other site 759350003806 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 759350003807 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 759350003808 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 759350003809 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 759350003810 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759350003811 Integrase core domain; Region: rve; pfam00665 759350003812 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 759350003813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 759350003814 DNA-binding interface [nucleotide binding]; DNA binding site 759350003815 Integrase core domain; Region: rve; pfam00665 759350003816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350003817 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759350003818 Walker A motif; other site 759350003819 ATP binding site [chemical binding]; other site 759350003820 Walker B motif; other site 759350003821 arginine finger; other site 759350003822 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 759350003823 Winged helix-turn helix; Region: HTH_29; pfam13551 759350003824 DNA-binding interface [nucleotide binding]; DNA binding site 759350003825 Integrase core domain; Region: rve; pfam00665 759350003826 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759350003827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350003828 Walker A motif; other site 759350003829 ATP binding site [chemical binding]; other site 759350003830 Walker B motif; other site 759350003831 Transposase, Mutator family; Region: Transposase_mut; pfam00872 759350003832 MULE transposase domain; Region: MULE; pfam10551 759350003833 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 759350003834 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 759350003835 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 759350003836 active site 759350003837 catalytic residues [active] 759350003838 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 759350003839 active site 759350003840 catalytic residues [active] 759350003841 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 759350003842 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759350003843 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759350003844 DNA binding residues [nucleotide binding] 759350003845 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 759350003846 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 759350003847 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759350003848 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759350003849 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 759350003850 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 759350003851 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 759350003852 Walker A/P-loop; other site 759350003853 ATP binding site [chemical binding]; other site 759350003854 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 759350003855 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 759350003856 ABC transporter signature motif; other site 759350003857 Walker B; other site 759350003858 D-loop; other site 759350003859 H-loop/switch region; other site 759350003860 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 759350003861 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759350003862 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759350003863 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 759350003864 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 759350003865 proline aminopeptidase P II; Provisional; Region: PRK10879 759350003866 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 759350003867 active site 759350003868 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 759350003869 nudix motif; other site 759350003870 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759350003871 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759350003872 Walker A/P-loop; other site 759350003873 ATP binding site [chemical binding]; other site 759350003874 Q-loop/lid; other site 759350003875 ABC transporter signature motif; other site 759350003876 Walker B; other site 759350003877 D-loop; other site 759350003878 H-loop/switch region; other site 759350003879 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759350003880 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759350003881 Walker A/P-loop; other site 759350003882 ATP binding site [chemical binding]; other site 759350003883 Q-loop/lid; other site 759350003884 ABC transporter signature motif; other site 759350003885 Walker B; other site 759350003886 D-loop; other site 759350003887 H-loop/switch region; other site 759350003888 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759350003889 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759350003890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350003891 dimer interface [polypeptide binding]; other site 759350003892 conserved gate region; other site 759350003893 ABC-ATPase subunit interface; other site 759350003894 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759350003895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350003896 dimer interface [polypeptide binding]; other site 759350003897 conserved gate region; other site 759350003898 putative PBP binding loops; other site 759350003899 ABC-ATPase subunit interface; other site 759350003900 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759350003901 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 759350003902 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 759350003903 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 759350003904 active site 759350003905 dimer interface [polypeptide binding]; other site 759350003906 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 759350003907 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 759350003908 active site 759350003909 trimer interface [polypeptide binding]; other site 759350003910 allosteric site; other site 759350003911 active site lid [active] 759350003912 hexamer (dimer of trimers) interface [polypeptide binding]; other site 759350003913 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 759350003914 non-specific DNA interactions [nucleotide binding]; other site 759350003915 DNA binding site [nucleotide binding] 759350003916 sequence specific DNA binding site [nucleotide binding]; other site 759350003917 putative cAMP binding site [chemical binding]; other site 759350003918 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759350003919 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 759350003920 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759350003921 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 759350003922 nucleotide binding site [chemical binding]; other site 759350003923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759350003924 putative DNA binding site [nucleotide binding]; other site 759350003925 Transcriptional regulators [Transcription]; Region: MarR; COG1846 759350003926 putative Zn2+ binding site [ion binding]; other site 759350003927 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759350003928 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759350003929 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 759350003930 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 759350003931 putative substrate binding site [chemical binding]; other site 759350003932 putative ATP binding site [chemical binding]; other site 759350003933 Uncharacterized conserved protein [Function unknown]; Region: COG3538 759350003934 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 759350003935 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 759350003936 putative active cleft [active] 759350003937 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350003938 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350003939 DNA binding site [nucleotide binding] 759350003940 domain linker motif; other site 759350003941 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350003942 ligand binding site [chemical binding]; other site 759350003943 dimerization interface [polypeptide binding]; other site 759350003944 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 759350003945 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 759350003946 active site 759350003947 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 759350003948 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 759350003949 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 759350003950 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350003951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350003952 dimer interface [polypeptide binding]; other site 759350003953 conserved gate region; other site 759350003954 putative PBP binding loops; other site 759350003955 ABC-ATPase subunit interface; other site 759350003956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350003957 dimer interface [polypeptide binding]; other site 759350003958 conserved gate region; other site 759350003959 putative PBP binding loops; other site 759350003960 ABC-ATPase subunit interface; other site 759350003961 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350003962 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350003963 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 759350003964 active site 759350003965 catalytic site [active] 759350003966 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 759350003967 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 759350003968 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 759350003969 active site 759350003970 catalytic site [active] 759350003971 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 759350003972 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 759350003973 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 759350003974 putative active site [active] 759350003975 dimerization interface [polypeptide binding]; other site 759350003976 putative tRNAtyr binding site [nucleotide binding]; other site 759350003977 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 759350003978 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 759350003979 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 759350003980 Cell division protein FtsQ; Region: FtsQ; pfam03799 759350003981 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 759350003982 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 759350003983 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759350003984 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759350003985 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 759350003986 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 759350003987 active site 759350003988 homodimer interface [polypeptide binding]; other site 759350003989 cell division protein FtsW; Region: ftsW; TIGR02614 759350003990 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 759350003991 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 759350003992 NAD binding site [chemical binding]; other site 759350003993 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759350003994 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759350003995 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 759350003996 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 759350003997 Mg++ binding site [ion binding]; other site 759350003998 putative catalytic motif [active] 759350003999 putative substrate binding site [chemical binding]; other site 759350004000 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 759350004001 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 759350004002 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759350004003 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759350004004 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 759350004005 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 759350004006 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 759350004007 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 759350004008 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 759350004009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759350004010 S-adenosylmethionine binding site [chemical binding]; other site 759350004011 cell division protein MraZ; Reviewed; Region: PRK00326 759350004012 MraZ protein; Region: MraZ; pfam02381 759350004013 MraZ protein; Region: MraZ; pfam02381 759350004014 Part of AAA domain; Region: AAA_19; pfam13245 759350004015 Family description; Region: UvrD_C_2; pfam13538 759350004016 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 759350004017 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 759350004018 ligand binding site [chemical binding]; other site 759350004019 NAD binding site [chemical binding]; other site 759350004020 tetramer interface [polypeptide binding]; other site 759350004021 catalytic site [active] 759350004022 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 759350004023 L-serine binding site [chemical binding]; other site 759350004024 ACT domain interface; other site 759350004025 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 759350004026 ATP cone domain; Region: ATP-cone; pfam03477 759350004027 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759350004028 LexA repressor; Validated; Region: PRK00215 759350004029 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 759350004030 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 759350004031 Catalytic site [active] 759350004032 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 759350004033 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 759350004034 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 759350004035 NAD binding site [chemical binding]; other site 759350004036 dimer interface [polypeptide binding]; other site 759350004037 substrate binding site [chemical binding]; other site 759350004038 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759350004039 GTPases [General function prediction only]; Region: HflX; COG2262 759350004040 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 759350004041 HflX GTPase family; Region: HflX; cd01878 759350004042 G1 box; other site 759350004043 GTP/Mg2+ binding site [chemical binding]; other site 759350004044 Switch I region; other site 759350004045 G2 box; other site 759350004046 G3 box; other site 759350004047 Switch II region; other site 759350004048 G4 box; other site 759350004049 G5 box; other site 759350004050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759350004051 S-adenosylmethionine binding site [chemical binding]; other site 759350004052 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 759350004053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759350004054 ATP binding site [chemical binding]; other site 759350004055 putative Mg++ binding site [ion binding]; other site 759350004056 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759350004057 nucleotide binding region [chemical binding]; other site 759350004058 ATP-binding site [chemical binding]; other site 759350004059 Helicase associated domain (HA2); Region: HA2; pfam04408 759350004060 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 759350004061 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 759350004062 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 759350004063 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 759350004064 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 759350004065 putative active site [active] 759350004066 putative catalytic site [active] 759350004067 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350004068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350004069 dimer interface [polypeptide binding]; other site 759350004070 conserved gate region; other site 759350004071 putative PBP binding loops; other site 759350004072 ABC-ATPase subunit interface; other site 759350004073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350004074 dimer interface [polypeptide binding]; other site 759350004075 conserved gate region; other site 759350004076 putative PBP binding loops; other site 759350004077 ABC-ATPase subunit interface; other site 759350004078 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 759350004079 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350004080 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350004081 DNA binding site [nucleotide binding] 759350004082 domain linker motif; other site 759350004083 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350004084 dimerization interface [polypeptide binding]; other site 759350004085 ligand binding site [chemical binding]; other site 759350004086 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 759350004087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350004088 putative substrate translocation pore; other site 759350004089 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 759350004090 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 759350004091 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 759350004092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 759350004093 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 759350004094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 759350004095 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 759350004096 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 759350004097 catalytic residues [active] 759350004098 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 759350004099 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 759350004100 putative active site [active] 759350004101 oxyanion strand; other site 759350004102 catalytic triad [active] 759350004103 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 759350004104 putative active site pocket [active] 759350004105 4-fold oligomerization interface [polypeptide binding]; other site 759350004106 metal binding residues [ion binding]; metal-binding site 759350004107 3-fold/trimer interface [polypeptide binding]; other site 759350004108 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 759350004109 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759350004110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350004111 homodimer interface [polypeptide binding]; other site 759350004112 catalytic residue [active] 759350004113 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 759350004114 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 759350004115 NAD binding site [chemical binding]; other site 759350004116 dimerization interface [polypeptide binding]; other site 759350004117 product binding site; other site 759350004118 substrate binding site [chemical binding]; other site 759350004119 zinc binding site [ion binding]; other site 759350004120 catalytic residues [active] 759350004121 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 759350004122 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 759350004123 N- and C-terminal domain interface [polypeptide binding]; other site 759350004124 active site 759350004125 MgATP binding site [chemical binding]; other site 759350004126 catalytic site [active] 759350004127 metal binding site [ion binding]; metal-binding site 759350004128 xylulose binding site [chemical binding]; other site 759350004129 putative homodimer interface [polypeptide binding]; other site 759350004130 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759350004131 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 759350004132 active site 759350004133 catalytic tetrad [active] 759350004134 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 759350004135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759350004136 Coenzyme A binding pocket [chemical binding]; other site 759350004137 myosin-cross-reactive antigen; Provisional; Region: PRK13977 759350004138 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 759350004139 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 759350004140 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 759350004141 active site 759350004142 PHP Thumb interface [polypeptide binding]; other site 759350004143 metal binding site [ion binding]; metal-binding site 759350004144 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 759350004145 generic binding surface II; other site 759350004146 generic binding surface I; other site 759350004147 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 759350004148 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 759350004149 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 759350004150 active site 759350004151 lipoprotein signal peptidase; Provisional; Region: PRK14771 759350004152 DivIVA protein; Region: DivIVA; pfam05103 759350004153 DivIVA domain; Region: DivI1A_domain; TIGR03544 759350004154 YGGT family; Region: YGGT; pfam02325 759350004155 Protein of unknown function (DUF552); Region: DUF552; pfam04472 759350004156 cell division protein FtsZ; Validated; Region: PRK09330 759350004157 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 759350004158 nucleotide binding site [chemical binding]; other site 759350004159 SulA interaction site; other site 759350004160 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 759350004161 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 759350004162 FMN binding site [chemical binding]; other site 759350004163 active site 759350004164 catalytic residues [active] 759350004165 substrate binding site [chemical binding]; other site 759350004166 glycyl-tRNA synthetase; Provisional; Region: PRK04173 759350004167 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 759350004168 motif 1; other site 759350004169 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 759350004170 active site 759350004171 motif 2; other site 759350004172 motif 3; other site 759350004173 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 759350004174 anticodon binding site; other site 759350004175 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 759350004176 substrate binding site [chemical binding]; other site 759350004177 multimerization interface [polypeptide binding]; other site 759350004178 ATP binding site [chemical binding]; other site 759350004179 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 759350004180 thiamine phosphate binding site [chemical binding]; other site 759350004181 active site 759350004182 pyrophosphate binding site [ion binding]; other site 759350004183 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 759350004184 ThiC-associated domain; Region: ThiC-associated; pfam13667 759350004185 ThiC family; Region: ThiC; pfam01964 759350004186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350004187 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759350004188 Walker A motif; other site 759350004189 ATP binding site [chemical binding]; other site 759350004190 Walker B motif; other site 759350004191 arginine finger; other site 759350004192 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 759350004193 substrate binding site [chemical binding]; other site 759350004194 dimer interface [polypeptide binding]; other site 759350004195 ATP binding site [chemical binding]; other site 759350004196 Domain of unknown function DUF77; Region: DUF77; pfam01910 759350004197 benzoate transport; Region: 2A0115; TIGR00895 759350004198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350004199 putative substrate translocation pore; other site 759350004200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350004201 putative substrate translocation pore; other site 759350004202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 759350004203 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759350004204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350004205 active site 759350004206 phosphorylation site [posttranslational modification] 759350004207 intermolecular recognition site; other site 759350004208 dimerization interface [polypeptide binding]; other site 759350004209 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 759350004210 DNA binding residues [nucleotide binding] 759350004211 dimerization interface [polypeptide binding]; other site 759350004212 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 759350004213 serpin-like protein; Provisional; Region: PHA02660 759350004214 reactive center loop; other site 759350004215 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350004216 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350004217 DNA binding site [nucleotide binding] 759350004218 domain linker motif; other site 759350004219 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 759350004220 putative dimerization interface [polypeptide binding]; other site 759350004221 putative ligand binding site [chemical binding]; other site 759350004222 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 759350004223 galactoside permease; Reviewed; Region: lacY; PRK09528 759350004224 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 759350004225 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 759350004226 substrate binding [chemical binding]; other site 759350004227 active site 759350004228 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759350004229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350004230 dimer interface [polypeptide binding]; other site 759350004231 conserved gate region; other site 759350004232 putative PBP binding loops; other site 759350004233 ABC-ATPase subunit interface; other site 759350004234 NMT1/THI5 like; Region: NMT1; pfam09084 759350004235 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 759350004236 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 759350004237 active site 759350004238 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 759350004239 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 759350004240 catalytic residue [active] 759350004241 putative FPP diphosphate binding site; other site 759350004242 putative FPP binding hydrophobic cleft; other site 759350004243 dimer interface [polypeptide binding]; other site 759350004244 putative IPP diphosphate binding site; other site 759350004245 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 759350004246 Recombination protein O N terminal; Region: RecO_N; pfam11967 759350004247 Recombination protein O C terminal; Region: RecO_C; pfam02565 759350004248 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 759350004249 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 759350004250 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 759350004251 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 759350004252 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 759350004253 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 759350004254 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 759350004255 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 759350004256 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 759350004257 DivIVA domain; Region: DivI1A_domain; TIGR03544 759350004258 DivIVA domain; Region: DivI1A_domain; TIGR03544 759350004259 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 759350004260 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 759350004261 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 759350004262 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 759350004263 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 759350004264 Part of AAA domain; Region: AAA_19; pfam13245 759350004265 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 759350004266 Family description; Region: UvrD_C_2; pfam13538 759350004267 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 759350004268 substrate binding site [chemical binding]; other site 759350004269 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 759350004270 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 759350004271 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 759350004272 active site 759350004273 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 759350004274 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 759350004275 putative active site [active] 759350004276 redox center [active] 759350004277 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 759350004278 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 759350004279 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 759350004280 glutamate racemase; Provisional; Region: PRK00865 759350004281 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 759350004282 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 759350004283 active site 759350004284 nucleophile elbow; other site 759350004285 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 759350004286 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 759350004287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350004288 dimer interface [polypeptide binding]; other site 759350004289 conserved gate region; other site 759350004290 putative PBP binding loops; other site 759350004291 ABC-ATPase subunit interface; other site 759350004292 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759350004293 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759350004294 substrate binding pocket [chemical binding]; other site 759350004295 membrane-bound complex binding site; other site 759350004296 hinge residues; other site 759350004297 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 759350004298 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 759350004299 Walker A/P-loop; other site 759350004300 ATP binding site [chemical binding]; other site 759350004301 Q-loop/lid; other site 759350004302 ABC transporter signature motif; other site 759350004303 Walker B; other site 759350004304 D-loop; other site 759350004305 H-loop/switch region; other site 759350004306 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 759350004307 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 759350004308 metal binding site [ion binding]; metal-binding site 759350004309 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 759350004310 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 759350004311 Walker A/P-loop; other site 759350004312 ATP binding site [chemical binding]; other site 759350004313 Q-loop/lid; other site 759350004314 ABC transporter signature motif; other site 759350004315 Walker B; other site 759350004316 D-loop; other site 759350004317 H-loop/switch region; other site 759350004318 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 759350004319 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 759350004320 Walker A/P-loop; other site 759350004321 ATP binding site [chemical binding]; other site 759350004322 Q-loop/lid; other site 759350004323 ABC transporter signature motif; other site 759350004324 Walker B; other site 759350004325 D-loop; other site 759350004326 H-loop/switch region; other site 759350004327 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759350004328 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 759350004329 TM-ABC transporter signature motif; other site 759350004330 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 759350004331 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 759350004332 TM-ABC transporter signature motif; other site 759350004333 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 759350004334 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759350004335 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 759350004336 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 759350004337 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 759350004338 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 759350004339 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 759350004340 catalytic residues [active] 759350004341 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 759350004342 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 759350004343 homodimer interface [polypeptide binding]; other site 759350004344 substrate-cofactor binding pocket; other site 759350004345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350004346 catalytic residue [active] 759350004347 Predicted esterase [General function prediction only]; Region: COG0400 759350004348 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 759350004349 translation elongation factor EF-G; Region: EF-G; TIGR00484 759350004350 G1 box; other site 759350004351 putative GEF interaction site [polypeptide binding]; other site 759350004352 GTP/Mg2+ binding site [chemical binding]; other site 759350004353 Switch I region; other site 759350004354 G2 box; other site 759350004355 G3 box; other site 759350004356 Switch II region; other site 759350004357 G4 box; other site 759350004358 G5 box; other site 759350004359 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 759350004360 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 759350004361 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 759350004362 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 759350004363 active site 759350004364 catalytic site [active] 759350004365 substrate binding site [chemical binding]; other site 759350004366 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 759350004367 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 759350004368 catalytic site [active] 759350004369 G-X2-G-X-G-K; other site 759350004370 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 759350004371 active site 759350004372 dimer interface [polypeptide binding]; other site 759350004373 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 759350004374 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 759350004375 ATP-grasp domain; Region: ATP-grasp_4; cl17255 759350004376 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 759350004377 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 759350004378 ATP-grasp domain; Region: ATP-grasp_4; cl17255 759350004379 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 759350004380 IMP binding site; other site 759350004381 dimer interface [polypeptide binding]; other site 759350004382 interdomain contacts; other site 759350004383 partial ornithine binding site; other site 759350004384 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 759350004385 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 759350004386 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 759350004387 catalytic site [active] 759350004388 subunit interface [polypeptide binding]; other site 759350004389 transcription antitermination factor NusB; Region: nusB; TIGR01951 759350004390 putative RNA binding site [nucleotide binding]; other site 759350004391 elongation factor P; Validated; Region: PRK00529 759350004392 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 759350004393 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 759350004394 RNA binding site [nucleotide binding]; other site 759350004395 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 759350004396 RNA binding site [nucleotide binding]; other site 759350004397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350004398 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 759350004399 Walker A/P-loop; other site 759350004400 ATP binding site [chemical binding]; other site 759350004401 Q-loop/lid; other site 759350004402 ABC transporter signature motif; other site 759350004403 Walker B; other site 759350004404 D-loop; other site 759350004405 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 759350004406 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 759350004407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 759350004408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759350004409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759350004410 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 759350004411 active site 759350004412 catalytic residues [active] 759350004413 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 759350004414 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 759350004415 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 759350004416 Helix-turn-helix domain; Region: HTH_38; pfam13936 759350004417 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 759350004418 Integrase core domain; Region: rve; pfam00665 759350004419 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 759350004420 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 759350004421 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 759350004422 putative active site [active] 759350004423 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350004424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350004425 dimer interface [polypeptide binding]; other site 759350004426 conserved gate region; other site 759350004427 putative PBP binding loops; other site 759350004428 ABC-ATPase subunit interface; other site 759350004429 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 759350004430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350004431 dimer interface [polypeptide binding]; other site 759350004432 conserved gate region; other site 759350004433 putative PBP binding loops; other site 759350004434 ABC-ATPase subunit interface; other site 759350004435 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350004436 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350004437 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350004438 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350004439 DNA binding site [nucleotide binding] 759350004440 domain linker motif; other site 759350004441 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759350004442 Domain of unknown function DUF59; Region: DUF59; cl00941 759350004443 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 759350004444 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 759350004445 Walker A motif; other site 759350004446 Ligase N family; Region: LIGANc; smart00532 759350004447 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 759350004448 nucleotide binding pocket [chemical binding]; other site 759350004449 K-X-D-G motif; other site 759350004450 catalytic site [active] 759350004451 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 759350004452 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 759350004453 Helix-hairpin-helix motif; Region: HHH; pfam00633 759350004454 helix-hairpin-helix signature motif; other site 759350004455 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 759350004456 Dimer interface [polypeptide binding]; other site 759350004457 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 759350004458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350004459 Walker A/P-loop; other site 759350004460 ATP binding site [chemical binding]; other site 759350004461 ABC transporter signature motif; other site 759350004462 Walker B; other site 759350004463 D-loop; other site 759350004464 H-loop/switch region; other site 759350004465 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 759350004466 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759350004467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350004468 homodimer interface [polypeptide binding]; other site 759350004469 catalytic residue [active] 759350004470 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759350004471 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 759350004472 nucleotide binding site [chemical binding]; other site 759350004473 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 759350004474 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 759350004475 Probable Catalytic site; other site 759350004476 Predicted membrane protein [Function unknown]; Region: COG3601 759350004477 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 759350004478 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 759350004479 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759350004480 Walker A/P-loop; other site 759350004481 ATP binding site [chemical binding]; other site 759350004482 Q-loop/lid; other site 759350004483 ABC transporter signature motif; other site 759350004484 Walker B; other site 759350004485 D-loop; other site 759350004486 H-loop/switch region; other site 759350004487 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 759350004488 Walker A/P-loop; other site 759350004489 ATP binding site [chemical binding]; other site 759350004490 Q-loop/lid; other site 759350004491 ABC transporter signature motif; other site 759350004492 Walker B; other site 759350004493 D-loop; other site 759350004494 H-loop/switch region; other site 759350004495 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 759350004496 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 759350004497 Membrane protein of unknown function; Region: DUF360; pfam04020 759350004498 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 759350004499 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 759350004500 NAD binding site [chemical binding]; other site 759350004501 ligand binding site [chemical binding]; other site 759350004502 catalytic site [active] 759350004503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350004504 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 759350004505 putative substrate translocation pore; other site 759350004506 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 759350004507 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759350004508 TM-ABC transporter signature motif; other site 759350004509 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 759350004510 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759350004511 TM-ABC transporter signature motif; other site 759350004512 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 759350004513 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 759350004514 Walker A/P-loop; other site 759350004515 ATP binding site [chemical binding]; other site 759350004516 Q-loop/lid; other site 759350004517 ABC transporter signature motif; other site 759350004518 Walker B; other site 759350004519 D-loop; other site 759350004520 H-loop/switch region; other site 759350004521 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 759350004522 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759350004523 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 759350004524 lipoprotein LpqB; Provisional; Region: PRK13613 759350004525 Sporulation and spore germination; Region: Germane; pfam10646 759350004526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759350004527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 759350004528 dimerization interface [polypeptide binding]; other site 759350004529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759350004530 dimer interface [polypeptide binding]; other site 759350004531 phosphorylation site [posttranslational modification] 759350004532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759350004533 ATP binding site [chemical binding]; other site 759350004534 Mg2+ binding site [ion binding]; other site 759350004535 G-X-G motif; other site 759350004536 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759350004537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350004538 active site 759350004539 phosphorylation site [posttranslational modification] 759350004540 intermolecular recognition site; other site 759350004541 dimerization interface [polypeptide binding]; other site 759350004542 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759350004543 DNA binding site [nucleotide binding] 759350004544 recombination factor protein RarA; Reviewed; Region: PRK13342 759350004545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350004546 Walker A motif; other site 759350004547 ATP binding site [chemical binding]; other site 759350004548 Walker B motif; other site 759350004549 arginine finger; other site 759350004550 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 759350004551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759350004552 ATP binding site [chemical binding]; other site 759350004553 putative Mg++ binding site [ion binding]; other site 759350004554 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759350004555 nucleotide binding region [chemical binding]; other site 759350004556 ATP-binding site [chemical binding]; other site 759350004557 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 759350004558 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 759350004559 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 759350004560 Lamin Tail Domain; Region: LTD; pfam00932 759350004561 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 759350004562 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 759350004563 putative active site [active] 759350004564 putative metal binding site [ion binding]; other site 759350004565 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 759350004566 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 759350004567 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 759350004568 active site 759350004569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350004570 dimer interface [polypeptide binding]; other site 759350004571 conserved gate region; other site 759350004572 putative PBP binding loops; other site 759350004573 ABC-ATPase subunit interface; other site 759350004574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350004575 dimer interface [polypeptide binding]; other site 759350004576 conserved gate region; other site 759350004577 ABC-ATPase subunit interface; other site 759350004578 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759350004579 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759350004580 substrate binding pocket [chemical binding]; other site 759350004581 membrane-bound complex binding site; other site 759350004582 hinge residues; other site 759350004583 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 759350004584 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 759350004585 Walker A/P-loop; other site 759350004586 ATP binding site [chemical binding]; other site 759350004587 Q-loop/lid; other site 759350004588 ABC transporter signature motif; other site 759350004589 Walker B; other site 759350004590 D-loop; other site 759350004591 H-loop/switch region; other site 759350004592 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 759350004593 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 759350004594 dimer interface [polypeptide binding]; other site 759350004595 anticodon binding site; other site 759350004596 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 759350004597 motif 1; other site 759350004598 dimer interface [polypeptide binding]; other site 759350004599 active site 759350004600 motif 2; other site 759350004601 GAD domain; Region: GAD; pfam02938 759350004602 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 759350004603 active site 759350004604 motif 3; other site 759350004605 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 759350004606 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 759350004607 dimer interface [polypeptide binding]; other site 759350004608 motif 1; other site 759350004609 active site 759350004610 motif 2; other site 759350004611 motif 3; other site 759350004612 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 759350004613 anticodon binding site; other site 759350004614 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 759350004615 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 759350004616 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 759350004617 active site 759350004618 metal binding site [ion binding]; metal-binding site 759350004619 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 759350004620 Creatinine amidohydrolase; Region: Creatininase; pfam02633 759350004621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350004622 metabolite-proton symporter; Region: 2A0106; TIGR00883 759350004623 putative substrate translocation pore; other site 759350004624 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 759350004625 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 759350004626 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 759350004627 cytosine deaminase; Provisional; Region: PRK09230 759350004628 active site 759350004629 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 759350004630 Clp amino terminal domain; Region: Clp_N; pfam02861 759350004631 Clp amino terminal domain; Region: Clp_N; pfam02861 759350004632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350004633 Walker A motif; other site 759350004634 ATP binding site [chemical binding]; other site 759350004635 Walker B motif; other site 759350004636 arginine finger; other site 759350004637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350004638 Walker A motif; other site 759350004639 ATP binding site [chemical binding]; other site 759350004640 Walker B motif; other site 759350004641 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 759350004642 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 759350004643 Ligand Binding Site [chemical binding]; other site 759350004644 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 759350004645 Ligand Binding Site [chemical binding]; other site 759350004646 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 759350004647 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 759350004648 Double zinc ribbon; Region: DZR; pfam12773 759350004649 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 759350004650 Double zinc ribbon; Region: DZR; pfam12773 759350004651 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 759350004652 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 759350004653 DNA-binding site [nucleotide binding]; DNA binding site 759350004654 RNA-binding motif; other site 759350004655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759350004656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 759350004657 dimerization interface [polypeptide binding]; other site 759350004658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759350004659 dimer interface [polypeptide binding]; other site 759350004660 phosphorylation site [posttranslational modification] 759350004661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759350004662 ATP binding site [chemical binding]; other site 759350004663 G-X-G motif; other site 759350004664 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759350004665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350004666 active site 759350004667 phosphorylation site [posttranslational modification] 759350004668 intermolecular recognition site; other site 759350004669 dimerization interface [polypeptide binding]; other site 759350004670 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759350004671 DNA binding site [nucleotide binding] 759350004672 Repair protein; Region: Repair_PSII; cl01535 759350004673 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 759350004674 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 759350004675 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 759350004676 ring oligomerisation interface [polypeptide binding]; other site 759350004677 ATP/Mg binding site [chemical binding]; other site 759350004678 stacking interactions; other site 759350004679 hinge regions; other site 759350004680 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 759350004681 DNA-binding site [nucleotide binding]; DNA binding site 759350004682 RNA-binding motif; other site 759350004683 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 759350004684 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 759350004685 ligand binding site [chemical binding]; other site 759350004686 active site 759350004687 UGI interface [polypeptide binding]; other site 759350004688 catalytic site [active] 759350004689 MoxR-like ATPases [General function prediction only]; Region: COG0714 759350004690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 759350004691 Protein of unknown function DUF58; Region: DUF58; pfam01882 759350004692 von Willebrand factor type A domain; Region: VWA_2; pfam13519 759350004693 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 759350004694 metal ion-dependent adhesion site (MIDAS); other site 759350004695 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 759350004696 PGAP1-like protein; Region: PGAP1; pfam07819 759350004697 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 759350004698 adenylosuccinate lyase; Provisional; Region: PRK09285 759350004699 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 759350004700 tetramer interface [polypeptide binding]; other site 759350004701 active site 759350004702 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 759350004703 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 759350004704 IHF dimer interface [polypeptide binding]; other site 759350004705 IHF - DNA interface [nucleotide binding]; other site 759350004706 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 759350004707 ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687 759350004708 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 759350004709 active site 759350004710 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 759350004711 Pup-ligase protein; Region: Pup_ligase; cl15463 759350004712 proteasome ATPase; Region: pup_AAA; TIGR03689 759350004713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350004714 Walker A motif; other site 759350004715 ATP binding site [chemical binding]; other site 759350004716 Walker B motif; other site 759350004717 arginine finger; other site 759350004718 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 759350004719 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 759350004720 phosphoserine phosphatase SerB; Region: serB; TIGR00338 759350004721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759350004722 motif II; other site 759350004723 primosome assembly protein PriA; Provisional; Region: PRK14873 759350004724 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 759350004725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759350004726 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 759350004727 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 759350004728 putative active site [active] 759350004729 substrate binding site [chemical binding]; other site 759350004730 putative cosubstrate binding site; other site 759350004731 catalytic site [active] 759350004732 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 759350004733 substrate binding site [chemical binding]; other site 759350004734 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 759350004735 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 759350004736 S-adenosylmethionine synthetase; Validated; Region: PRK05250 759350004737 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 759350004738 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 759350004739 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 759350004740 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 759350004741 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 759350004742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759350004743 ATP binding site [chemical binding]; other site 759350004744 putative Mg++ binding site [ion binding]; other site 759350004745 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 759350004746 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 759350004747 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 759350004748 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 759350004749 HsdM N-terminal domain; Region: HsdM_N; pfam12161 759350004750 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 759350004751 Methyltransferase domain; Region: Methyltransf_26; pfam13659 759350004752 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 759350004753 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 759350004754 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 759350004755 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 759350004756 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 759350004757 HIGH motif; other site 759350004758 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 759350004759 active site 759350004760 KMSKS motif; other site 759350004761 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 759350004762 tRNA binding surface [nucleotide binding]; other site 759350004763 anticodon binding site; other site 759350004764 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 759350004765 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759350004766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350004767 homodimer interface [polypeptide binding]; other site 759350004768 catalytic residue [active] 759350004769 fragment of beta galactosidase; BLJ_1514 759350004770 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350004771 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350004772 DNA binding site [nucleotide binding] 759350004773 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 759350004774 putative dimerization interface [polypeptide binding]; other site 759350004775 putative ligand binding site [chemical binding]; other site 759350004776 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 759350004777 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 759350004778 substrate binding site [chemical binding]; other site 759350004779 dimer interface [polypeptide binding]; other site 759350004780 ATP binding site [chemical binding]; other site 759350004781 D-ribose pyranase; Provisional; Region: PRK11797 759350004782 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 759350004783 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 759350004784 ligand binding site [chemical binding]; other site 759350004785 dimerization interface [polypeptide binding]; other site 759350004786 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759350004787 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 759350004788 TM-ABC transporter signature motif; other site 759350004789 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 759350004790 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 759350004791 Walker A/P-loop; other site 759350004792 ATP binding site [chemical binding]; other site 759350004793 Q-loop/lid; other site 759350004794 ABC transporter signature motif; other site 759350004795 Walker B; other site 759350004796 D-loop; other site 759350004797 H-loop/switch region; other site 759350004798 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 759350004799 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350004800 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350004801 DNA binding site [nucleotide binding] 759350004802 domain linker motif; other site 759350004803 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759350004804 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 759350004805 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759350004806 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 759350004807 Walker A/P-loop; other site 759350004808 ATP binding site [chemical binding]; other site 759350004809 Q-loop/lid; other site 759350004810 ABC transporter signature motif; other site 759350004811 Walker B; other site 759350004812 D-loop; other site 759350004813 H-loop/switch region; other site 759350004814 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 759350004815 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759350004816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350004817 Walker A/P-loop; other site 759350004818 ATP binding site [chemical binding]; other site 759350004819 Q-loop/lid; other site 759350004820 ABC transporter signature motif; other site 759350004821 Walker B; other site 759350004822 D-loop; other site 759350004823 H-loop/switch region; other site 759350004824 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 759350004825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 759350004826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 759350004827 metal binding site [ion binding]; metal-binding site 759350004828 active site 759350004829 I-site; other site 759350004830 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 759350004831 putative metal binding residues [ion binding]; other site 759350004832 signature motif; other site 759350004833 dimer interface [polypeptide binding]; other site 759350004834 active site 759350004835 polyP binding site; other site 759350004836 substrate binding site [chemical binding]; other site 759350004837 acceptor-phosphate pocket; other site 759350004838 CotH protein; Region: CotH; pfam08757 759350004839 Predicted membrane protein [Function unknown]; Region: COG4267 759350004840 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 759350004841 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 759350004842 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 759350004843 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 759350004844 NodB motif; other site 759350004845 putative active site [active] 759350004846 putative catalytic site [active] 759350004847 putative Zn binding site [ion binding]; other site 759350004848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759350004849 active site 759350004850 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 759350004851 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 759350004852 GAF domain; Region: GAF_3; pfam13492 759350004853 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 759350004854 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 759350004855 MULE transposase domain; Region: MULE; pfam10551 759350004856 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 759350004857 nucleotidyltransferase substrate binding protein, HI0074 family; Region: HI0074; TIGR01987 759350004858 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 759350004859 active site 759350004860 NTP binding site [chemical binding]; other site 759350004861 metal binding triad [ion binding]; metal-binding site 759350004862 antibiotic binding site [chemical binding]; other site 759350004863 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 759350004864 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 759350004865 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 759350004866 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 759350004867 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 759350004868 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 759350004869 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 759350004870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 759350004871 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 759350004872 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 759350004873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 759350004874 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 759350004875 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 759350004876 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 759350004877 ATP cone domain; Region: ATP-cone; pfam03477 759350004878 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 759350004879 Class III ribonucleotide reductase; Region: RNR_III; cd01675 759350004880 active site 759350004881 Zn binding site [ion binding]; other site 759350004882 glycine loop; other site 759350004883 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 759350004884 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 759350004885 generic binding surface II; other site 759350004886 generic binding surface I; other site 759350004887 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 759350004888 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 759350004889 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 759350004890 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 759350004891 acyl-activating enzyme (AAE) consensus motif; other site 759350004892 putative AMP binding site [chemical binding]; other site 759350004893 putative active site [active] 759350004894 putative CoA binding site [chemical binding]; other site 759350004895 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 759350004896 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 759350004897 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 759350004898 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 759350004899 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 759350004900 putative catalytic site [active] 759350004901 putative metal binding site [ion binding]; other site 759350004902 putative phosphate binding site [ion binding]; other site 759350004903 exopolyphosphatase; Region: exo_poly_only; TIGR03706 759350004904 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 759350004905 nucleotide binding site [chemical binding]; other site 759350004906 hypothetical protein; Provisional; Region: PRK08960 759350004907 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759350004908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350004909 homodimer interface [polypeptide binding]; other site 759350004910 catalytic residue [active] 759350004911 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 759350004912 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 759350004913 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 759350004914 additional DNA contacts [nucleotide binding]; other site 759350004915 mismatch recognition site; other site 759350004916 active site 759350004917 zinc binding site [ion binding]; other site 759350004918 DNA intercalation site [nucleotide binding]; other site 759350004919 SWIM zinc finger; Region: SWIM; pfam04434 759350004920 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 759350004921 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 759350004922 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759350004923 ATP binding site [chemical binding]; other site 759350004924 putative Mg++ binding site [ion binding]; other site 759350004925 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759350004926 nucleotide binding region [chemical binding]; other site 759350004927 ATP-binding site [chemical binding]; other site 759350004928 Penicillinase repressor; Region: Pencillinase_R; cl17580 759350004929 WYL domain; Region: WYL; pfam13280 759350004930 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 759350004931 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 759350004932 putative trimer interface [polypeptide binding]; other site 759350004933 putative CoA binding site [chemical binding]; other site 759350004934 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 759350004935 Citrate synthase; Region: Citrate_synt; pfam00285 759350004936 oxalacetate binding site [chemical binding]; other site 759350004937 citrylCoA binding site [chemical binding]; other site 759350004938 coenzyme A binding site [chemical binding]; other site 759350004939 catalytic triad [active] 759350004940 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 759350004941 active site 759350004942 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 759350004943 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 759350004944 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 759350004945 active site 759350004946 Zn binding site [ion binding]; other site 759350004947 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 759350004948 dimer interface [polypeptide binding]; other site 759350004949 ssDNA binding site [nucleotide binding]; other site 759350004950 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759350004951 prolyl-tRNA synthetase; Provisional; Region: PRK09194 759350004952 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 759350004953 dimer interface [polypeptide binding]; other site 759350004954 motif 1; other site 759350004955 active site 759350004956 motif 2; other site 759350004957 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 759350004958 putative deacylase active site [active] 759350004959 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 759350004960 active site 759350004961 motif 3; other site 759350004962 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 759350004963 anticodon binding site; other site 759350004964 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 759350004965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759350004966 FeS/SAM binding site; other site 759350004967 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 759350004968 putative ligand binding pocket/active site [active] 759350004969 putative metal binding site [ion binding]; other site 759350004970 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 759350004971 AMMECR1; Region: AMMECR1; pfam01871 759350004972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350004973 PIF1-like helicase; Region: PIF1; pfam05970 759350004974 Walker A motif; other site 759350004975 ATP binding site [chemical binding]; other site 759350004976 Walker B motif; other site 759350004977 arginine finger; other site 759350004978 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 759350004979 catalytic site [active] 759350004980 putative active site [active] 759350004981 putative substrate binding site [chemical binding]; other site 759350004982 dimer interface [polypeptide binding]; other site 759350004983 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 759350004984 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 759350004985 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 759350004986 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 759350004987 active site 759350004988 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 759350004989 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 759350004990 Mg++ binding site [ion binding]; other site 759350004991 putative catalytic motif [active] 759350004992 substrate binding site [chemical binding]; other site 759350004993 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 759350004994 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 759350004995 putative trimer interface [polypeptide binding]; other site 759350004996 putative CoA binding site [chemical binding]; other site 759350004997 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 759350004998 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 759350004999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759350005000 S-adenosylmethionine binding site [chemical binding]; other site 759350005001 peptide chain release factor 1; Validated; Region: prfA; PRK00591 759350005002 PCRF domain; Region: PCRF; pfam03462 759350005003 RF-1 domain; Region: RF-1; pfam00472 759350005004 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 759350005005 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 759350005006 non-specific DNA interactions [nucleotide binding]; other site 759350005007 DNA binding site [nucleotide binding] 759350005008 sequence specific DNA binding site [nucleotide binding]; other site 759350005009 putative cAMP binding site [chemical binding]; other site 759350005010 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759350005011 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759350005012 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 759350005013 N- and C-terminal domain interface [polypeptide binding]; other site 759350005014 D-xylulose kinase; Region: XylB; TIGR01312 759350005015 active site 759350005016 MgATP binding site [chemical binding]; other site 759350005017 catalytic site [active] 759350005018 metal binding site [ion binding]; metal-binding site 759350005019 xylulose binding site [chemical binding]; other site 759350005020 putative homodimer interface [polypeptide binding]; other site 759350005021 Transposase, Mutator family; Region: Transposase_mut; pfam00872 759350005022 MULE transposase domain; Region: MULE; pfam10551 759350005023 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759350005024 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 759350005025 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 759350005026 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759350005027 TM-ABC transporter signature motif; other site 759350005028 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 759350005029 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 759350005030 Walker A/P-loop; other site 759350005031 ATP binding site [chemical binding]; other site 759350005032 Q-loop/lid; other site 759350005033 ABC transporter signature motif; other site 759350005034 Walker B; other site 759350005035 D-loop; other site 759350005036 H-loop/switch region; other site 759350005037 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 759350005038 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 759350005039 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 759350005040 putative ligand binding site [chemical binding]; other site 759350005041 Right handed beta helix region; Region: Beta_helix; pfam13229 759350005042 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 759350005043 trimer interface [polypeptide binding]; other site 759350005044 active site 759350005045 substrate binding site [chemical binding]; other site 759350005046 CoA binding site [chemical binding]; other site 759350005047 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 759350005048 active site 759350005049 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 759350005050 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 759350005051 active site 759350005052 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 759350005053 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 759350005054 substrate binding pocket [chemical binding]; other site 759350005055 catalytic triad [active] 759350005056 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 759350005057 Domain of unknown function (DUF303); Region: DUF303; pfam03629 759350005058 Domain of unknown function (DUF303); Region: DUF303; pfam03629 759350005059 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 759350005060 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 759350005061 inhibitor binding site; inhibition site 759350005062 active site 759350005063 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 759350005064 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350005065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350005066 dimer interface [polypeptide binding]; other site 759350005067 conserved gate region; other site 759350005068 putative PBP binding loops; other site 759350005069 ABC-ATPase subunit interface; other site 759350005070 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 759350005071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350005072 dimer interface [polypeptide binding]; other site 759350005073 conserved gate region; other site 759350005074 putative PBP binding loops; other site 759350005075 ABC-ATPase subunit interface; other site 759350005076 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350005077 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 759350005078 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350005079 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350005080 DNA binding site [nucleotide binding] 759350005081 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 759350005082 putative dimerization interface [polypeptide binding]; other site 759350005083 putative ligand binding site [chemical binding]; other site 759350005084 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 759350005085 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 759350005086 dimer interface [polypeptide binding]; other site 759350005087 active site 759350005088 metal binding site [ion binding]; metal-binding site 759350005089 xylose isomerase; Provisional; Region: PRK05474 759350005090 xylose isomerase; Region: xylose_isom_A; TIGR02630 759350005091 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 759350005092 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 759350005093 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 759350005094 active site 759350005095 catalytic residues [active] 759350005096 metal binding site [ion binding]; metal-binding site 759350005097 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759350005098 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 759350005099 active site 759350005100 catalytic tetrad [active] 759350005101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350005102 putative substrate translocation pore; other site 759350005103 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 759350005104 Transcriptional regulators [Transcription]; Region: MarR; COG1846 759350005105 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 759350005106 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 759350005107 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759350005108 TM-ABC transporter signature motif; other site 759350005109 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 759350005110 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 759350005111 Walker A/P-loop; other site 759350005112 ATP binding site [chemical binding]; other site 759350005113 Q-loop/lid; other site 759350005114 ABC transporter signature motif; other site 759350005115 Walker B; other site 759350005116 D-loop; other site 759350005117 H-loop/switch region; other site 759350005118 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 759350005119 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 759350005120 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 759350005121 putative ligand binding site [chemical binding]; other site 759350005122 MarR family; Region: MarR_2; pfam12802 759350005123 Transcriptional regulators [Transcription]; Region: MarR; COG1846 759350005124 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759350005125 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 759350005126 nucleotide binding site [chemical binding]; other site 759350005127 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759350005128 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 759350005129 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 759350005130 Walker A/P-loop; other site 759350005131 ATP binding site [chemical binding]; other site 759350005132 Q-loop/lid; other site 759350005133 ABC transporter signature motif; other site 759350005134 Walker B; other site 759350005135 D-loop; other site 759350005136 H-loop/switch region; other site 759350005137 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 759350005138 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 759350005139 nucleotide binding site [chemical binding]; other site 759350005140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350005141 putative substrate translocation pore; other site 759350005142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350005143 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 759350005144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350005145 Walker A/P-loop; other site 759350005146 ATP binding site [chemical binding]; other site 759350005147 Q-loop/lid; other site 759350005148 ABC transporter signature motif; other site 759350005149 Walker B; other site 759350005150 D-loop; other site 759350005151 H-loop/switch region; other site 759350005152 ABC transporter; Region: ABC_tran_2; pfam12848 759350005153 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759350005154 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 759350005155 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 759350005156 active site 759350005157 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 759350005158 catalytic triad [active] 759350005159 dimer interface [polypeptide binding]; other site 759350005160 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 759350005161 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 759350005162 homooctamer interface [polypeptide binding]; other site 759350005163 active site 759350005164 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 759350005165 catalytic center binding site [active] 759350005166 ATP binding site [chemical binding]; other site 759350005167 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 759350005168 catalytic center binding site [active] 759350005169 ATP binding site [chemical binding]; other site 759350005170 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 759350005171 dihydropteroate synthase; Region: DHPS; TIGR01496 759350005172 substrate binding pocket [chemical binding]; other site 759350005173 dimer interface [polypeptide binding]; other site 759350005174 inhibitor binding site; inhibition site 759350005175 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 759350005176 GTP cyclohydrolase I; Provisional; Region: PLN03044 759350005177 active site 759350005178 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 759350005179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350005180 Walker A motif; other site 759350005181 ATP binding site [chemical binding]; other site 759350005182 Walker B motif; other site 759350005183 arginine finger; other site 759350005184 Peptidase family M41; Region: Peptidase_M41; pfam01434 759350005185 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759350005186 active site 759350005187 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 759350005188 Ligand Binding Site [chemical binding]; other site 759350005189 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 759350005190 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 759350005191 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 759350005192 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 759350005193 Walker A/P-loop; other site 759350005194 ATP binding site [chemical binding]; other site 759350005195 Q-loop/lid; other site 759350005196 ABC transporter signature motif; other site 759350005197 Walker B; other site 759350005198 D-loop; other site 759350005199 H-loop/switch region; other site 759350005200 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 759350005201 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 759350005202 DXD motif; other site 759350005203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759350005204 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 759350005205 Domain of unknown function DUF20; Region: UPF0118; pfam01594 759350005206 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 759350005207 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 759350005208 active site 759350005209 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759350005210 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 759350005211 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 759350005212 dimer interface [polypeptide binding]; other site 759350005213 active site 759350005214 metal binding site [ion binding]; metal-binding site 759350005215 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 759350005216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759350005217 S-adenosylmethionine binding site [chemical binding]; other site 759350005218 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 759350005219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759350005220 NAD(P) binding site [chemical binding]; other site 759350005221 active site 759350005222 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 759350005223 potential protein location (hypothetical protein BLJ_1647 [Bifidobacterium longum subsp. longum JDM301]) that overlaps RNA (tRNA-E) 759350005224 MULE transposase domain; Region: MULE; pfam10551 759350005225 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 759350005226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350005227 Walker A/P-loop; other site 759350005228 ATP binding site [chemical binding]; other site 759350005229 Q-loop/lid; other site 759350005230 ABC transporter signature motif; other site 759350005231 Walker B; other site 759350005232 D-loop; other site 759350005233 H-loop/switch region; other site 759350005234 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759350005235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 759350005236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759350005237 Coenzyme A binding pocket [chemical binding]; other site 759350005238 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 759350005239 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 759350005240 MULE transposase domain; Region: MULE; pfam10551 759350005241 AzlC protein; Region: AzlC; cl00570 759350005242 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 759350005243 Low molecular weight phosphatase family; Region: LMWPc; cd00115 759350005244 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 759350005245 active site 759350005246 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 759350005247 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 759350005248 folate binding site [chemical binding]; other site 759350005249 NADP+ binding site [chemical binding]; other site 759350005250 thymidylate synthase; Reviewed; Region: thyA; PRK01827 759350005251 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 759350005252 dimerization interface [polypeptide binding]; other site 759350005253 active site 759350005254 OsmC-like protein; Region: OsmC; pfam02566 759350005255 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 759350005256 Ligand Binding Site [chemical binding]; other site 759350005257 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 759350005258 Ligand Binding Site [chemical binding]; other site 759350005259 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 759350005260 NlpC/P60 family; Region: NLPC_P60; pfam00877 759350005261 NlpC/P60 family; Region: NLPC_P60; cl17555 759350005262 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 759350005263 CHAP domain; Region: CHAP; pfam05257 759350005264 phosphoserine aminotransferase; Provisional; Region: PRK03080 759350005265 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759350005266 catalytic residue [active] 759350005267 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 759350005268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759350005269 ATP binding site [chemical binding]; other site 759350005270 Mg2+ binding site [ion binding]; other site 759350005271 G-X-G motif; other site 759350005272 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 759350005273 PhoU domain; Region: PhoU; pfam01895 759350005274 PhoU domain; Region: PhoU; pfam01895 759350005275 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759350005276 catalytic core [active] 759350005277 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 759350005278 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 759350005279 UbiA prenyltransferase family; Region: UbiA; pfam01040 759350005280 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 759350005281 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 759350005282 dimer interface [polypeptide binding]; other site 759350005283 putative anticodon binding site; other site 759350005284 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 759350005285 motif 1; other site 759350005286 dimer interface [polypeptide binding]; other site 759350005287 active site 759350005288 motif 2; other site 759350005289 motif 3; other site 759350005290 MFS transport protein AraJ; Provisional; Region: PRK10091 759350005291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350005292 putative substrate translocation pore; other site 759350005293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759350005294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759350005295 binding surface 759350005296 TPR motif; other site 759350005297 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759350005298 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 759350005299 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 759350005300 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 759350005301 PspC domain; Region: PspC; pfam04024 759350005302 PspC domain; Region: PspC; pfam04024 759350005303 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 759350005304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759350005305 ATP binding site [chemical binding]; other site 759350005306 Mg2+ binding site [ion binding]; other site 759350005307 G-X-G motif; other site 759350005308 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759350005309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759350005310 active site 759350005311 phosphorylation site [posttranslational modification] 759350005312 intermolecular recognition site; other site 759350005313 dimerization interface [polypeptide binding]; other site 759350005314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 759350005315 DNA binding residues [nucleotide binding] 759350005316 dimerization interface [polypeptide binding]; other site 759350005317 UDP-glucose 4-epimerase; Region: PLN02240 759350005318 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 759350005319 NAD binding site [chemical binding]; other site 759350005320 homodimer interface [polypeptide binding]; other site 759350005321 active site 759350005322 substrate binding site [chemical binding]; other site 759350005323 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 759350005324 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 759350005325 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 759350005326 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 759350005327 Phosphotransferase enzyme family; Region: APH; pfam01636 759350005328 active site 759350005329 substrate binding site [chemical binding]; other site 759350005330 ATP binding site [chemical binding]; other site 759350005331 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 759350005332 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 759350005333 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350005334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350005335 dimer interface [polypeptide binding]; other site 759350005336 conserved gate region; other site 759350005337 putative PBP binding loops; other site 759350005338 ABC-ATPase subunit interface; other site 759350005339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350005340 dimer interface [polypeptide binding]; other site 759350005341 conserved gate region; other site 759350005342 ABC-ATPase subunit interface; other site 759350005343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350005344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350005345 Helix-turn-helix domain; Region: HTH_17; cl17695 759350005346 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 759350005347 active site 759350005348 catalytic residues [active] 759350005349 DNA binding site [nucleotide binding] 759350005350 Int/Topo IB signature motif; other site 759350005351 seryl-tRNA synthetase; Provisional; Region: PRK05431 759350005352 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 759350005353 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 759350005354 dimer interface [polypeptide binding]; other site 759350005355 active site 759350005356 motif 1; other site 759350005357 motif 2; other site 759350005358 motif 3; other site 759350005359 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 759350005360 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 759350005361 transcriptional antiterminator BglG; Provisional; Region: PRK09772 759350005362 CAT RNA binding domain; Region: CAT_RBD; smart01061 759350005363 PRD domain; Region: PRD; pfam00874 759350005364 PRD domain; Region: PRD; pfam00874 759350005365 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 759350005366 active site turn [active] 759350005367 phosphorylation site [posttranslational modification] 759350005368 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 759350005369 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 759350005370 HPr interaction site; other site 759350005371 glycerol kinase (GK) interaction site [polypeptide binding]; other site 759350005372 active site 759350005373 phosphorylation site [posttranslational modification] 759350005374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350005375 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 759350005376 putative substrate translocation pore; other site 759350005377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350005378 phosphoglucomutase; Validated; Region: PRK07564 759350005379 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 759350005380 active site 759350005381 substrate binding site [chemical binding]; other site 759350005382 metal binding site [ion binding]; metal-binding site 759350005383 Transcriptional regulator; Region: Rrf2; pfam02082 759350005384 Rrf2 family protein; Region: rrf2_super; TIGR00738 759350005385 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 759350005386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759350005387 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 759350005388 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 759350005389 RNA/DNA hybrid binding site [nucleotide binding]; other site 759350005390 active site 759350005391 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 759350005392 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759350005393 active site 759350005394 dimer interface [polypeptide binding]; other site 759350005395 DNA repair protein RadA; Provisional; Region: PRK11823 759350005396 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 759350005397 Walker A motif; other site 759350005398 ATP binding site [chemical binding]; other site 759350005399 Walker B motif; other site 759350005400 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 759350005401 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 759350005402 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 759350005403 active site 759350005404 Riboflavin kinase; Region: Flavokinase; pfam01687 759350005405 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 759350005406 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 759350005407 RNA binding site [nucleotide binding]; other site 759350005408 active site 759350005409 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 759350005410 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 759350005411 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 759350005412 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 759350005413 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 759350005414 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 759350005415 G1 box; other site 759350005416 putative GEF interaction site [polypeptide binding]; other site 759350005417 GTP/Mg2+ binding site [chemical binding]; other site 759350005418 Switch I region; other site 759350005419 G2 box; other site 759350005420 G3 box; other site 759350005421 Switch II region; other site 759350005422 G4 box; other site 759350005423 G5 box; other site 759350005424 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 759350005425 Translation-initiation factor 2; Region: IF-2; pfam11987 759350005426 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 759350005427 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 759350005428 NusA N-terminal domain; Region: NusA_N; pfam08529 759350005429 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 759350005430 RNA binding site [nucleotide binding]; other site 759350005431 homodimer interface [polypeptide binding]; other site 759350005432 NusA-like KH domain; Region: KH_5; pfam13184 759350005433 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 759350005434 G-X-X-G motif; other site 759350005435 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350005436 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350005437 DNA binding site [nucleotide binding] 759350005438 domain linker motif; other site 759350005439 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350005440 dimerization interface [polypeptide binding]; other site 759350005441 ligand binding site [chemical binding]; other site 759350005442 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 759350005443 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 759350005444 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 759350005445 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 759350005446 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 759350005447 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 759350005448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 759350005449 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 759350005450 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 759350005451 dimerization interface 3.5A [polypeptide binding]; other site 759350005452 active site 759350005453 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 759350005454 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 759350005455 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 759350005456 alphaNTD homodimer interface [polypeptide binding]; other site 759350005457 alphaNTD - beta interaction site [polypeptide binding]; other site 759350005458 alphaNTD - beta' interaction site [polypeptide binding]; other site 759350005459 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 759350005460 30S ribosomal protein S11; Validated; Region: PRK05309 759350005461 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 759350005462 30S ribosomal protein S13; Region: bact_S13; TIGR03631 759350005463 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 759350005464 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 759350005465 rRNA binding site [nucleotide binding]; other site 759350005466 predicted 30S ribosome binding site; other site 759350005467 adenylate kinase; Reviewed; Region: adk; PRK00279 759350005468 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 759350005469 AMP-binding site [chemical binding]; other site 759350005470 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 759350005471 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 759350005472 SecY translocase; Region: SecY; pfam00344 759350005473 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 759350005474 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 759350005475 23S rRNA binding site [nucleotide binding]; other site 759350005476 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 759350005477 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 759350005478 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 759350005479 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 759350005480 23S rRNA interface [nucleotide binding]; other site 759350005481 L21e interface [polypeptide binding]; other site 759350005482 5S rRNA interface [nucleotide binding]; other site 759350005483 L27 interface [polypeptide binding]; other site 759350005484 L5 interface [polypeptide binding]; other site 759350005485 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 759350005486 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 759350005487 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 759350005488 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 759350005489 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 759350005490 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 759350005491 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 759350005492 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 759350005493 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 759350005494 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 759350005495 RNA binding site [nucleotide binding]; other site 759350005496 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 759350005497 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 759350005498 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 759350005499 23S rRNA interface [nucleotide binding]; other site 759350005500 putative translocon interaction site; other site 759350005501 signal recognition particle (SRP54) interaction site; other site 759350005502 L23 interface [polypeptide binding]; other site 759350005503 trigger factor interaction site; other site 759350005504 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 759350005505 23S rRNA interface [nucleotide binding]; other site 759350005506 5S rRNA interface [nucleotide binding]; other site 759350005507 putative antibiotic binding site [chemical binding]; other site 759350005508 L25 interface [polypeptide binding]; other site 759350005509 L27 interface [polypeptide binding]; other site 759350005510 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 759350005511 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 759350005512 G-X-X-G motif; other site 759350005513 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 759350005514 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 759350005515 putative translocon binding site; other site 759350005516 protein-rRNA interface [nucleotide binding]; other site 759350005517 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 759350005518 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 759350005519 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 759350005520 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 759350005521 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 759350005522 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 759350005523 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 759350005524 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 759350005525 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 759350005526 YwiC-like protein; Region: YwiC; pfam14256 759350005527 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 759350005528 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 759350005529 putative catalytic cysteine [active] 759350005530 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 759350005531 putative active site [active] 759350005532 metal binding site [ion binding]; metal-binding site 759350005533 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 759350005534 non-specific DNA interactions [nucleotide binding]; other site 759350005535 DNA binding site [nucleotide binding] 759350005536 sequence specific DNA binding site [nucleotide binding]; other site 759350005537 putative cAMP binding site [chemical binding]; other site 759350005538 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759350005539 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759350005540 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759350005541 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 759350005542 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 759350005543 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 759350005544 active site 759350005545 catalytic site [active] 759350005546 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 759350005547 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 759350005548 23S rRNA interface [nucleotide binding]; other site 759350005549 L3 interface [polypeptide binding]; other site 759350005550 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 759350005551 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 759350005552 Uncharacterized conserved protein [Function unknown]; Region: COG1739 759350005553 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 759350005554 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 759350005555 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 759350005556 dimerization interface [polypeptide binding]; other site 759350005557 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 759350005558 NAD binding site [chemical binding]; other site 759350005559 ligand binding site [chemical binding]; other site 759350005560 catalytic site [active] 759350005561 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 759350005562 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 759350005563 putative active site [active] 759350005564 putative metal binding site [ion binding]; other site 759350005565 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 759350005566 DNA polymerase IV; Validated; Region: PRK03858 759350005567 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 759350005568 active site 759350005569 DNA binding site [nucleotide binding] 759350005570 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 759350005571 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759350005572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350005573 homodimer interface [polypeptide binding]; other site 759350005574 catalytic residue [active] 759350005575 Ferredoxin [Energy production and conversion]; Region: COG1146 759350005576 4Fe-4S binding domain; Region: Fer4; pfam00037 759350005577 amino acid transporter; Region: 2A0306; TIGR00909 759350005578 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 759350005579 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 759350005580 FAD binding domain; Region: FAD_binding_4; pfam01565 759350005581 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 759350005582 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 759350005583 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 759350005584 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 759350005585 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 759350005586 oligomerisation interface [polypeptide binding]; other site 759350005587 mobile loop; other site 759350005588 roof hairpin; other site 759350005589 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 759350005590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759350005591 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 759350005592 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 759350005593 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 759350005594 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 759350005595 Part of AAA domain; Region: AAA_19; pfam13245 759350005596 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 759350005597 phosphopeptide binding site; other site 759350005598 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 759350005599 peripheral dimer interface [polypeptide binding]; other site 759350005600 core dimer interface [polypeptide binding]; other site 759350005601 L10 interface [polypeptide binding]; other site 759350005602 L11 interface [polypeptide binding]; other site 759350005603 putative EF-Tu interaction site [polypeptide binding]; other site 759350005604 putative EF-G interaction site [polypeptide binding]; other site 759350005605 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 759350005606 23S rRNA interface [nucleotide binding]; other site 759350005607 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 759350005608 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 759350005609 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 759350005610 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 759350005611 oligomer interface [polypeptide binding]; other site 759350005612 RNA binding site [nucleotide binding]; other site 759350005613 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 759350005614 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 759350005615 RNase E interface [polypeptide binding]; other site 759350005616 trimer interface [polypeptide binding]; other site 759350005617 active site 759350005618 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 759350005619 putative nucleic acid binding region [nucleotide binding]; other site 759350005620 G-X-X-G motif; other site 759350005621 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 759350005622 RNA binding site [nucleotide binding]; other site 759350005623 domain interface; other site 759350005624 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 759350005625 16S/18S rRNA binding site [nucleotide binding]; other site 759350005626 S13e-L30e interaction site [polypeptide binding]; other site 759350005627 25S rRNA binding site [nucleotide binding]; other site 759350005628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350005629 Walker A/P-loop; other site 759350005630 ATP binding site [chemical binding]; other site 759350005631 ABC transporter; Region: ABC_tran; pfam00005 759350005632 Q-loop/lid; other site 759350005633 ABC transporter signature motif; other site 759350005634 Walker B; other site 759350005635 D-loop; other site 759350005636 H-loop/switch region; other site 759350005637 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 759350005638 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 759350005639 Walker A/P-loop; other site 759350005640 ATP binding site [chemical binding]; other site 759350005641 Q-loop/lid; other site 759350005642 ABC transporter signature motif; other site 759350005643 Walker B; other site 759350005644 D-loop; other site 759350005645 H-loop/switch region; other site 759350005646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 759350005647 Transposase; Region: DDE_Tnp_ISL3; pfam01610 759350005648 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 759350005649 Cna protein B-type domain; Region: Cna_B; pfam05738 759350005650 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 759350005651 metal ion-dependent adhesion site (MIDAS); other site 759350005652 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 759350005653 domain interaction interfaces [polypeptide binding]; other site 759350005654 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 759350005655 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 759350005656 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 759350005657 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 759350005658 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 759350005659 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 759350005660 phosphate binding site [ion binding]; other site 759350005661 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 759350005662 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 759350005663 putative active site [active] 759350005664 putative catalytic site [active] 759350005665 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 759350005666 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 759350005667 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 759350005668 putative NAD(P) binding site [chemical binding]; other site 759350005669 active site 759350005670 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 759350005671 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 759350005672 active site 759350005673 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 759350005674 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 759350005675 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 759350005676 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 759350005677 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 759350005678 ATP-grasp domain; Region: ATP-grasp_4; cl17255 759350005679 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 759350005680 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 759350005681 carboxyltransferase (CT) interaction site; other site 759350005682 biotinylation site [posttranslational modification]; other site 759350005683 BioY family; Region: BioY; pfam02632 759350005684 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 759350005685 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 759350005686 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 759350005687 Transcriptional regulator [Transcription]; Region: IclR; COG1414 759350005688 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 759350005689 Bacterial transcriptional regulator; Region: IclR; pfam01614 759350005690 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 759350005691 Transcriptional regulator [Transcription]; Region: IclR; COG1414 759350005692 Bacterial transcriptional regulator; Region: IclR; pfam01614 759350005693 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 759350005694 mRNA/rRNA interface [nucleotide binding]; other site 759350005695 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 759350005696 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 759350005697 23S rRNA interface [nucleotide binding]; other site 759350005698 L7/L12 interface [polypeptide binding]; other site 759350005699 putative thiostrepton binding site; other site 759350005700 L25 interface [polypeptide binding]; other site 759350005701 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 759350005702 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 759350005703 putative homodimer interface [polypeptide binding]; other site 759350005704 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 759350005705 heterodimer interface [polypeptide binding]; other site 759350005706 homodimer interface [polypeptide binding]; other site 759350005707 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 759350005708 aspartate aminotransferase; Provisional; Region: PRK05764 759350005709 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759350005710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350005711 homodimer interface [polypeptide binding]; other site 759350005712 catalytic residue [active] 759350005713 gamma-glutamyl kinase; Provisional; Region: PRK05429 759350005714 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 759350005715 nucleotide binding site [chemical binding]; other site 759350005716 homotetrameric interface [polypeptide binding]; other site 759350005717 putative phosphate binding site [ion binding]; other site 759350005718 putative allosteric binding site; other site 759350005719 PUA domain; Region: PUA; pfam01472 759350005720 GTPase CgtA; Reviewed; Region: obgE; PRK12296 759350005721 GTP1/OBG; Region: GTP1_OBG; pfam01018 759350005722 Obg GTPase; Region: Obg; cd01898 759350005723 G1 box; other site 759350005724 GTP/Mg2+ binding site [chemical binding]; other site 759350005725 Switch I region; other site 759350005726 G2 box; other site 759350005727 G3 box; other site 759350005728 Switch II region; other site 759350005729 G4 box; other site 759350005730 G5 box; other site 759350005731 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 759350005732 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 759350005733 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 759350005734 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 759350005735 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 759350005736 homodimer interface [polypeptide binding]; other site 759350005737 oligonucleotide binding site [chemical binding]; other site 759350005738 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 759350005739 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 759350005740 metal binding site [ion binding]; metal-binding site 759350005741 putative dimer interface [polypeptide binding]; other site 759350005742 Predicted permeases [General function prediction only]; Region: COG0679 759350005743 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 759350005744 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 759350005745 inhibitor site; inhibition site 759350005746 active site 759350005747 dimer interface [polypeptide binding]; other site 759350005748 catalytic residue [active] 759350005749 Amidohydrolase; Region: Amidohydro_2; pfam04909 759350005750 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 759350005751 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 759350005752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350005753 putative substrate translocation pore; other site 759350005754 short chain dehydrogenase; Provisional; Region: PRK08628 759350005755 classical (c) SDRs; Region: SDR_c; cd05233 759350005756 NAD(P) binding site [chemical binding]; other site 759350005757 active site 759350005758 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 759350005759 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 759350005760 metal binding site [ion binding]; metal-binding site 759350005761 substrate binding pocket [chemical binding]; other site 759350005762 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350005763 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350005764 DNA binding site [nucleotide binding] 759350005765 domain linker motif; other site 759350005766 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759350005767 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 759350005768 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759350005769 Walker A/P-loop; other site 759350005770 ATP binding site [chemical binding]; other site 759350005771 Q-loop/lid; other site 759350005772 ABC transporter signature motif; other site 759350005773 Walker B; other site 759350005774 D-loop; other site 759350005775 H-loop/switch region; other site 759350005776 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 759350005777 putative active site [active] 759350005778 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 759350005779 dimer interface [polypeptide binding]; other site 759350005780 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 759350005781 nudix motif; other site 759350005782 homoserine kinase; Provisional; Region: PRK01212 759350005783 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 759350005784 homoserine dehydrogenase; Provisional; Region: PRK06349 759350005785 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 759350005786 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 759350005787 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 759350005788 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 759350005789 catalytic residue [active] 759350005790 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 759350005791 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759350005792 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 759350005793 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 759350005794 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759350005795 active site 759350005796 HIGH motif; other site 759350005797 nucleotide binding site [chemical binding]; other site 759350005798 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 759350005799 KMSK motif region; other site 759350005800 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 759350005801 tRNA binding surface [nucleotide binding]; other site 759350005802 anticodon binding site; other site 759350005803 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759350005804 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759350005805 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 759350005806 putative dimerization interface [polypeptide binding]; other site 759350005807 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 759350005808 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759350005809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350005810 homodimer interface [polypeptide binding]; other site 759350005811 catalytic residue [active] 759350005812 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 759350005813 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 759350005814 hinge; other site 759350005815 active site 759350005816 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 759350005817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759350005818 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 759350005819 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 759350005820 active site 759350005821 FMN binding site [chemical binding]; other site 759350005822 substrate binding site [chemical binding]; other site 759350005823 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 759350005824 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 759350005825 substrate binding site [chemical binding]; other site 759350005826 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 759350005827 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 759350005828 substrate binding site [chemical binding]; other site 759350005829 ligand binding site [chemical binding]; other site 759350005830 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 759350005831 Transcriptional regulator [Transcription]; Region: IclR; COG1414 759350005832 Bacterial transcriptional regulator; Region: IclR; pfam01614 759350005833 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 759350005834 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 759350005835 putative active site [active] 759350005836 putative metal binding site [ion binding]; other site 759350005837 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 759350005838 polyphosphate kinase; Provisional; Region: PRK05443 759350005839 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 759350005840 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 759350005841 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 759350005842 putative domain interface [polypeptide binding]; other site 759350005843 putative active site [active] 759350005844 catalytic site [active] 759350005845 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 759350005846 putative domain interface [polypeptide binding]; other site 759350005847 putative active site [active] 759350005848 catalytic site [active] 759350005849 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 759350005850 active site 759350005851 Ap6A binding site [chemical binding]; other site 759350005852 nudix motif; other site 759350005853 metal binding site [ion binding]; metal-binding site 759350005854 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759350005855 catalytic core [active] 759350005856 AAA domain; Region: AAA_14; pfam13173 759350005857 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 759350005858 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759350005859 active site 759350005860 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 759350005861 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 759350005862 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 759350005863 active site 759350005864 catalytic site [active] 759350005865 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 759350005866 active site 759350005867 HIGH motif; other site 759350005868 nucleotide binding site [chemical binding]; other site 759350005869 active site 759350005870 KMSKS motif; other site 759350005871 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 759350005872 Clp amino terminal domain; Region: Clp_N; pfam02861 759350005873 Clp amino terminal domain; Region: Clp_N; pfam02861 759350005874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350005875 Walker A motif; other site 759350005876 ATP binding site [chemical binding]; other site 759350005877 Walker B motif; other site 759350005878 arginine finger; other site 759350005879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350005880 Walker A motif; other site 759350005881 ATP binding site [chemical binding]; other site 759350005882 Walker B motif; other site 759350005883 arginine finger; other site 759350005884 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 759350005885 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 759350005886 active sites [active] 759350005887 tetramer interface [polypeptide binding]; other site 759350005888 Transcriptional regulator [Transcription]; Region: IclR; COG1414 759350005889 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 759350005890 Bacterial transcriptional regulator; Region: IclR; pfam01614 759350005891 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 759350005892 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 759350005893 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 759350005894 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 759350005895 Transposase, Mutator family; Region: Transposase_mut; pfam00872 759350005896 MULE transposase domain; Region: MULE; pfam10551 759350005897 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 759350005898 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759350005899 UDP-galactopyranose mutase; Region: GLF; pfam03275 759350005900 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 759350005901 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 759350005902 NAD binding site [chemical binding]; other site 759350005903 substrate binding site [chemical binding]; other site 759350005904 homodimer interface [polypeptide binding]; other site 759350005905 active site 759350005906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350005907 AAA domain; Region: AAA_23; pfam13476 759350005908 Walker A/P-loop; other site 759350005909 ATP binding site [chemical binding]; other site 759350005910 AAA domain; Region: AAA_21; pfam13304 759350005911 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759350005912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350005913 Walker A motif; other site 759350005914 ATP binding site [chemical binding]; other site 759350005915 Walker B motif; other site 759350005916 arginine finger; other site 759350005917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 759350005918 Integrase core domain; Region: rve; pfam00665 759350005919 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 759350005920 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 759350005921 Ligand binding site; other site 759350005922 Putative Catalytic site; other site 759350005923 DXD motif; other site 759350005924 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 759350005925 Acyltransferase family; Region: Acyl_transf_3; pfam01757 759350005926 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 759350005927 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 759350005928 active site 759350005929 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 759350005930 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 759350005931 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 759350005932 Ligand binding site; other site 759350005933 metal-binding site 759350005934 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 759350005935 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 759350005936 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 759350005937 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 759350005938 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 759350005939 Integrase core domain; Region: rve; pfam00665 759350005940 Integrase core domain; Region: rve_2; pfam13333 759350005941 Protein of unknown function (DUF2699); Region: DUF2699; pfam10919 759350005942 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 759350005943 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 759350005944 Walker A/P-loop; other site 759350005945 ATP binding site [chemical binding]; other site 759350005946 Q-loop/lid; other site 759350005947 ABC transporter signature motif; other site 759350005948 Walker B; other site 759350005949 D-loop; other site 759350005950 H-loop/switch region; other site 759350005951 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 759350005952 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 759350005953 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 759350005954 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 759350005955 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 759350005956 Ligand binding site; other site 759350005957 metal-binding site 759350005958 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 759350005959 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 759350005960 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 759350005961 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 759350005962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759350005963 NAD(P) binding site [chemical binding]; other site 759350005964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759350005965 active site 759350005966 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 759350005967 Acyltransferase family; Region: Acyl_transf_3; pfam01757 759350005968 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 759350005969 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759350005970 FtsX-like permease family; Region: FtsX; pfam02687 759350005971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350005972 ABC transporter; Region: ABC_tran; pfam00005 759350005973 Q-loop/lid; other site 759350005974 ABC transporter signature motif; other site 759350005975 Walker B; other site 759350005976 D-loop; other site 759350005977 H-loop/switch region; other site 759350005978 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759350005979 Zn2+ binding site [ion binding]; other site 759350005980 Mg2+ binding site [ion binding]; other site 759350005981 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 759350005982 putative active site [active] 759350005983 putative dimer interface [polypeptide binding]; other site 759350005984 K+ potassium transporter; Region: K_trans; pfam02705 759350005985 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 759350005986 active site 759350005987 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 759350005988 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 759350005989 Integrase core domain; Region: rve_2; pfam13333 759350005990 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 759350005991 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759350005992 active site 759350005993 DNA binding site [nucleotide binding] 759350005994 Int/Topo IB signature motif; other site 759350005995 INT_SG4, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 4, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases for which not much biochemical characterization is available; Region: INT_SG4; cd01187 759350005996 Int/Topo IB signature motif; other site 759350005997 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 759350005998 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759350005999 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 759350006000 Int/Topo IB signature motif; other site 759350006001 HTH-like domain; Region: HTH_21; pfam13276 759350006002 Integrase core domain; Region: rve; pfam00665 759350006003 Transposase; Region: DDE_Tnp_ISL3; pfam01610 759350006004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 759350006005 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 759350006006 active site 759350006007 MFS/sugar transport protein; Region: MFS_2; pfam13347 759350006008 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 759350006009 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 759350006010 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 759350006011 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 759350006012 alpha-galactosidase; Region: PLN02808; cl17638 759350006013 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350006014 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350006015 DNA binding site [nucleotide binding] 759350006016 domain linker motif; other site 759350006017 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350006018 dimerization interface [polypeptide binding]; other site 759350006019 ligand binding site [chemical binding]; other site 759350006020 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 759350006021 active site 759350006022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 759350006023 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 759350006024 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 759350006025 active site 759350006026 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 759350006027 active site 759350006028 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 759350006029 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 759350006030 active site 759350006031 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350006032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006033 dimer interface [polypeptide binding]; other site 759350006034 ABC-ATPase subunit interface; other site 759350006035 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 759350006036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006037 dimer interface [polypeptide binding]; other site 759350006038 conserved gate region; other site 759350006039 putative PBP binding loops; other site 759350006040 ABC-ATPase subunit interface; other site 759350006041 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350006042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350006043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350006044 DNA binding site [nucleotide binding] 759350006045 domain linker motif; other site 759350006046 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350006047 ligand binding site [chemical binding]; other site 759350006048 dimerization interface [polypeptide binding]; other site 759350006049 Protein of unknown function, DUF624; Region: DUF624; pfam04854 759350006050 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 759350006051 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759350006052 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 759350006053 Walker A/P-loop; other site 759350006054 ATP binding site [chemical binding]; other site 759350006055 Q-loop/lid; other site 759350006056 ABC transporter signature motif; other site 759350006057 Walker B; other site 759350006058 D-loop; other site 759350006059 H-loop/switch region; other site 759350006060 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 759350006061 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759350006062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350006063 Walker A/P-loop; other site 759350006064 ATP binding site [chemical binding]; other site 759350006065 Q-loop/lid; other site 759350006066 ABC transporter signature motif; other site 759350006067 Walker B; other site 759350006068 D-loop; other site 759350006069 H-loop/switch region; other site 759350006070 Archaeal ATPase; Region: Arch_ATPase; pfam01637 759350006071 AAA ATPase domain; Region: AAA_16; pfam13191 759350006072 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 759350006073 AAA domain; Region: AAA_14; pfam13173 759350006074 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 759350006075 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 759350006076 putative substrate binding site [chemical binding]; other site 759350006077 active site 759350006078 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350006079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006080 dimer interface [polypeptide binding]; other site 759350006081 conserved gate region; other site 759350006082 putative PBP binding loops; other site 759350006083 ABC-ATPase subunit interface; other site 759350006084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006085 dimer interface [polypeptide binding]; other site 759350006086 conserved gate region; other site 759350006087 putative PBP binding loops; other site 759350006088 ABC-ATPase subunit interface; other site 759350006089 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350006090 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350006091 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350006092 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350006093 DNA binding site [nucleotide binding] 759350006094 domain linker motif; other site 759350006095 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350006096 ligand binding site [chemical binding]; other site 759350006097 dimerization interface [polypeptide binding]; other site 759350006098 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 759350006099 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 759350006100 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 759350006101 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 759350006102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759350006103 Walker A motif; other site 759350006104 ATP binding site [chemical binding]; other site 759350006105 Walker B motif; other site 759350006106 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 759350006107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350006108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350006109 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 759350006110 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 759350006111 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 759350006112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759350006113 Walker A/P-loop; other site 759350006114 ATP binding site [chemical binding]; other site 759350006115 Q-loop/lid; other site 759350006116 ABC transporter signature motif; other site 759350006117 Walker B; other site 759350006118 D-loop; other site 759350006119 H-loop/switch region; other site 759350006120 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 759350006121 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759350006122 Walker A/P-loop; other site 759350006123 ATP binding site [chemical binding]; other site 759350006124 Q-loop/lid; other site 759350006125 ABC transporter signature motif; other site 759350006126 Walker B; other site 759350006127 D-loop; other site 759350006128 H-loop/switch region; other site 759350006129 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 759350006130 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759350006131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006132 dimer interface [polypeptide binding]; other site 759350006133 conserved gate region; other site 759350006134 putative PBP binding loops; other site 759350006135 ABC-ATPase subunit interface; other site 759350006136 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759350006137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006138 dimer interface [polypeptide binding]; other site 759350006139 conserved gate region; other site 759350006140 putative PBP binding loops; other site 759350006141 ABC-ATPase subunit interface; other site 759350006142 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 759350006143 trimer interface [polypeptide binding]; other site 759350006144 active site 759350006145 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 759350006146 active site 759350006147 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 759350006148 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 759350006149 active site 759350006150 HIGH motif; other site 759350006151 KMSKS motif; other site 759350006152 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 759350006153 tRNA binding surface [nucleotide binding]; other site 759350006154 anticodon binding site; other site 759350006155 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 759350006156 Predicted methyltransferases [General function prediction only]; Region: COG0313 759350006157 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 759350006158 putative SAM binding site [chemical binding]; other site 759350006159 putative homodimer interface [polypeptide binding]; other site 759350006160 MFS/sugar transport protein; Region: MFS_2; pfam13347 759350006161 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 759350006162 ApbE family; Region: ApbE; pfam02424 759350006163 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 759350006164 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759350006165 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 759350006166 Walker A/P-loop; other site 759350006167 ATP binding site [chemical binding]; other site 759350006168 Q-loop/lid; other site 759350006169 ABC transporter signature motif; other site 759350006170 Walker B; other site 759350006171 D-loop; other site 759350006172 H-loop/switch region; other site 759350006173 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 759350006174 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759350006175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759350006176 Walker A/P-loop; other site 759350006177 ATP binding site [chemical binding]; other site 759350006178 Q-loop/lid; other site 759350006179 ABC transporter signature motif; other site 759350006180 Walker B; other site 759350006181 D-loop; other site 759350006182 H-loop/switch region; other site 759350006183 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 759350006184 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 759350006185 active site 759350006186 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 759350006187 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 759350006188 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 759350006189 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 759350006190 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 759350006191 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 759350006192 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 759350006193 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 759350006194 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 759350006195 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 759350006196 Divergent AAA domain; Region: AAA_4; pfam04326 759350006197 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 759350006198 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 759350006199 Transcriptional regulators [Transcription]; Region: MarR; COG1846 759350006200 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 759350006201 non-specific DNA interactions [nucleotide binding]; other site 759350006202 DNA binding site [nucleotide binding] 759350006203 sequence specific DNA binding site [nucleotide binding]; other site 759350006204 putative cAMP binding site [chemical binding]; other site 759350006205 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759350006206 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 759350006207 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 759350006208 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 759350006209 active site 759350006210 catalytic site [active] 759350006211 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 759350006212 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 759350006213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006214 dimer interface [polypeptide binding]; other site 759350006215 conserved gate region; other site 759350006216 putative PBP binding loops; other site 759350006217 ABC-ATPase subunit interface; other site 759350006218 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350006219 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350006220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 759350006221 Transposase; Region: DDE_Tnp_ISL3; pfam01610 759350006222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 759350006223 Transposase; Region: HTH_Tnp_1; cl17663 759350006224 Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795 759350006225 FtsX-like permease family; Region: FtsX; pfam02687 759350006226 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 759350006227 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759350006228 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759350006229 Walker A/P-loop; other site 759350006230 ATP binding site [chemical binding]; other site 759350006231 Q-loop/lid; other site 759350006232 ABC transporter signature motif; other site 759350006233 Walker B; other site 759350006234 D-loop; other site 759350006235 H-loop/switch region; other site 759350006236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759350006237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759350006238 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 759350006239 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 759350006240 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 759350006241 AAA domain; Region: AAA_14; pfam13173 759350006242 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 759350006243 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 759350006244 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 759350006245 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 759350006246 active site 759350006247 Protein of unknown function, DUF624; Region: DUF624; pfam04854 759350006248 Protein of unknown function, DUF624; Region: DUF624; cl02369 759350006249 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350006250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006251 dimer interface [polypeptide binding]; other site 759350006252 conserved gate region; other site 759350006253 putative PBP binding loops; other site 759350006254 ABC-ATPase subunit interface; other site 759350006255 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 759350006256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006257 putative PBP binding loops; other site 759350006258 dimer interface [polypeptide binding]; other site 759350006259 ABC-ATPase subunit interface; other site 759350006260 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350006261 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350006262 DNA binding site [nucleotide binding] 759350006263 domain linker motif; other site 759350006264 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350006265 ligand binding site [chemical binding]; other site 759350006266 dimerization interface [polypeptide binding]; other site 759350006267 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 759350006268 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759350006269 catalytic core [active] 759350006270 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 759350006271 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 759350006272 dimer interface [polypeptide binding]; other site 759350006273 FMN binding site [chemical binding]; other site 759350006274 NADPH bind site [chemical binding]; other site 759350006275 Predicted membrane protein [Function unknown]; Region: COG1511 759350006276 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 759350006277 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 759350006278 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 759350006279 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 759350006280 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 759350006281 NAD-dependent deacetylase; Provisional; Region: PRK00481 759350006282 SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent...; Region: SIRT7; cd01410 759350006283 NAD+ binding site [chemical binding]; other site 759350006284 substrate binding site [chemical binding]; other site 759350006285 Zn binding site [ion binding]; other site 759350006286 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 759350006287 tetramer interface [polypeptide binding]; other site 759350006288 threonine dehydratase; Provisional; Region: PRK08198 759350006289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759350006290 catalytic residue [active] 759350006291 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 759350006292 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 759350006293 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 759350006294 Ca binding site [ion binding]; other site 759350006295 active site 759350006296 catalytic site [active] 759350006297 probable galactinol--sucrose galactosyltransferase 1; Region: PLN02355 759350006298 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 759350006299 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 759350006300 active site 759350006301 catalytic site [active] 759350006302 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350006303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006304 dimer interface [polypeptide binding]; other site 759350006305 conserved gate region; other site 759350006306 putative PBP binding loops; other site 759350006307 ABC-ATPase subunit interface; other site 759350006308 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 759350006309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006310 dimer interface [polypeptide binding]; other site 759350006311 conserved gate region; other site 759350006312 putative PBP binding loops; other site 759350006313 ABC-ATPase subunit interface; other site 759350006314 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350006315 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350006316 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 759350006317 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759350006318 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350006319 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350006320 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759350006321 DNA binding site [nucleotide binding] 759350006322 domain linker motif; other site 759350006323 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350006324 ligand binding site [chemical binding]; other site 759350006325 dimerization interface [polypeptide binding]; other site 759350006326 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759350006327 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 759350006328 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759350006329 ligand binding site [chemical binding]; other site 759350006330 dimerization interface [polypeptide binding]; other site 759350006331 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759350006332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006333 dimer interface [polypeptide binding]; other site 759350006334 conserved gate region; other site 759350006335 putative PBP binding loops; other site 759350006336 ABC-ATPase subunit interface; other site 759350006337 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 759350006338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759350006339 dimer interface [polypeptide binding]; other site 759350006340 conserved gate region; other site 759350006341 putative PBP binding loops; other site 759350006342 ABC-ATPase subunit interface; other site 759350006343 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759350006344 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 759350006345 MarR family; Region: MarR_2; pfam12802 759350006346 Transcriptional regulators [Transcription]; Region: MarR; COG1846 759350006347 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759350006348 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759350006349 Melibiase; Region: Melibiase; pfam02065 759350006350 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 759350006351 nucleoside/Zn binding site; other site 759350006352 dimer interface [polypeptide binding]; other site 759350006353 catalytic motif [active] 759350006354 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 759350006355 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 759350006356 Serine hydrolase (FSH1); Region: FSH1; pfam03959 759350006357 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 759350006358 trimer interface [polypeptide binding]; other site 759350006359 active site 759350006360 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 759350006361 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 759350006362 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 759350006363 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 759350006364 Soluble P-type ATPase [General function prediction only]; Region: COG4087 759350006365 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 759350006366 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 759350006367 AAA domain; Region: AAA_14; pfam13173 759350006368 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 759350006369 Nuclease-related domain; Region: NERD; pfam08378 759350006370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759350006371 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759350006372 putative substrate translocation pore; other site 759350006373 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 759350006374 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 759350006375 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 759350006376 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 759350006377 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 759350006378 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 759350006379 Walker A/P-loop; other site 759350006380 ATP binding site [chemical binding]; other site 759350006381 Q-loop/lid; other site 759350006382 ABC transporter signature motif; other site 759350006383 Walker B; other site 759350006384 D-loop; other site 759350006385 H-loop/switch region; other site 759350006386 TOBE domain; Region: TOBE_2; pfam08402 759350006387 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 759350006388 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 759350006389 active site 759350006390 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 759350006391 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 759350006392 dimer interface [polypeptide binding]; other site 759350006393 putative radical transfer pathway; other site 759350006394 diiron center [ion binding]; other site 759350006395 tyrosyl radical; other site 759350006396 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 759350006397 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 759350006398 Class I ribonucleotide reductase; Region: RNR_I; cd01679 759350006399 active site 759350006400 dimer interface [polypeptide binding]; other site 759350006401 catalytic residues [active] 759350006402 effector binding site; other site 759350006403 R2 peptide binding site; other site 759350006404 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 759350006405 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 759350006406 catalytic residues [active] 759350006407 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 759350006408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759350006409 non-specific DNA binding site [nucleotide binding]; other site 759350006410 salt bridge; other site 759350006411 sequence-specific DNA binding site [nucleotide binding]; other site 759350006412 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 759350006413 Ion channel; Region: Ion_trans_2; pfam07885 759350006414 AAA ATPase domain; Region: AAA_16; pfam13191 759350006415 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 759350006416 Catalytic domain of Protein Kinases; Region: PKc; cd00180 759350006417 active site 759350006418 ATP binding site [chemical binding]; other site 759350006419 substrate binding site [chemical binding]; other site 759350006420 activation loop (A-loop); other site 759350006421 Gamma interferon inducible lysosomal thiol reductase (GILT); Region: GILT; pfam03227 759350006422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 759350006423 Domain of unknown function (DUF348); Region: DUF348; pfam03990 759350006424 G5 domain; Region: G5; pfam07501 759350006425 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 759350006426 N-acetyl-D-glucosamine binding site [chemical binding]; other site 759350006427 catalytic residue [active] 759350006428 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 759350006429 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 759350006430 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 759350006431 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 759350006432 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 759350006433 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 759350006434 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 759350006435 active site 759350006436 NTP binding site [chemical binding]; other site 759350006437 metal binding triad [ion binding]; metal-binding site 759350006438 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 759350006439 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759350006440 Zn2+ binding site [ion binding]; other site 759350006441 Mg2+ binding site [ion binding]; other site 759350006442 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 759350006443 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 759350006444 active site 759350006445 Ap6A binding site [chemical binding]; other site 759350006446 nudix motif; other site 759350006447 metal binding site [ion binding]; metal-binding site 759350006448 integral membrane protein MviN; Region: mviN; TIGR01695 759350006449 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 759350006450 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 759350006451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759350006452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759350006453 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 759350006454 ParB-like nuclease domain; Region: ParB; smart00470 759350006455 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 759350006456 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759350006457 P-loop; other site 759350006458 Magnesium ion binding site [ion binding]; other site 759350006459 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759350006460 Magnesium ion binding site [ion binding]; other site 759350006461 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 759350006462 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 759350006463 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 759350006464 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 759350006465 G-X-X-G motif; other site 759350006466 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 759350006467 RxxxH motif; other site 759350006468 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 759350006469 Ribonuclease P; Region: Ribonuclease_P; pfam00825 759350006470 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399