-- dump date   	20140619_002726
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
565040000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
565040000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040000003	Walker A motif; other site
565040000004	ATP binding site [chemical binding]; other site
565040000005	Walker B motif; other site
565040000006	arginine finger; other site
565040000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
565040000008	DnaA box-binding interface [nucleotide binding]; other site
565040000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
565040000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
565040000011	putative DNA binding surface [nucleotide binding]; other site
565040000012	dimer interface [polypeptide binding]; other site
565040000013	beta-clamp/clamp loader binding surface; other site
565040000014	beta-clamp/translesion DNA polymerase binding surface; other site
565040000015	recombination protein F; Reviewed; Region: recF; PRK00064
565040000016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040000017	Walker A/P-loop; other site
565040000018	ATP binding site [chemical binding]; other site
565040000019	Q-loop/lid; other site
565040000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040000021	ABC transporter signature motif; other site
565040000022	Walker B; other site
565040000023	D-loop; other site
565040000024	H-loop/switch region; other site
565040000025	Protein of unknown function (DUF721); Region: DUF721; pfam05258
565040000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
565040000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
565040000028	Mg2+ binding site [ion binding]; other site
565040000029	G-X-G motif; other site
565040000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
565040000031	anchoring element; other site
565040000032	dimer interface [polypeptide binding]; other site
565040000033	ATP binding site [chemical binding]; other site
565040000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
565040000035	active site
565040000036	putative metal-binding site [ion binding]; other site
565040000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
565040000038	DNA gyrase subunit A; Validated; Region: PRK05560
565040000039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
565040000040	CAP-like domain; other site
565040000041	active site
565040000042	primary dimer interface [polypeptide binding]; other site
565040000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
565040000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
565040000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
565040000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
565040000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
565040000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
565040000049	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
565040000050	putative pectinesterase; Region: PLN02432; cl01911
565040000051	glutamate dehydrogenase; Provisional; Region: PRK09414
565040000052	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
565040000053	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
565040000054	NAD(P) binding site [chemical binding]; other site
565040000055	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
565040000056	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
565040000057	putative DNA binding site [nucleotide binding]; other site
565040000058	putative Zn2+ binding site [ion binding]; other site
565040000059	AsnC family; Region: AsnC_trans_reg; pfam01037
565040000060	aspartate aminotransferase; Provisional; Region: PRK05764
565040000061	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
565040000062	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040000063	homodimer interface [polypeptide binding]; other site
565040000064	catalytic residue [active]
565040000065	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040000066	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040000067	Integrase core domain; Region: rve; pfam00665
565040000068	AAA domain; Region: AAA_14; pfam13173
565040000069	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
565040000070	Protein of unknown function DUF45; Region: DUF45; pfam01863
565040000071	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
565040000072	AAA domain; Region: AAA_14; pfam13173
565040000073	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
565040000074	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
565040000075	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
565040000076	dimerization interface [polypeptide binding]; other site
565040000077	DPS ferroxidase diiron center [ion binding]; other site
565040000078	ion pore; other site
565040000079	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
565040000080	Domain of unknown function DUF21; Region: DUF21; pfam01595
565040000081	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
565040000082	Transporter associated domain; Region: CorC_HlyC; smart01091
565040000083	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
565040000084	active site clefts [active]
565040000085	zinc binding site [ion binding]; other site
565040000086	dimer interface [polypeptide binding]; other site
565040000087	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
565040000088	peroxiredoxin; Region: AhpC; TIGR03137
565040000089	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
565040000090	dimer interface [polypeptide binding]; other site
565040000091	decamer (pentamer of dimers) interface [polypeptide binding]; other site
565040000092	catalytic triad [active]
565040000093	peroxidatic and resolving cysteines [active]
565040000094	putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143
565040000095	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
565040000096	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
565040000097	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
565040000098	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
565040000099	catalytic residues [active]
565040000100	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040000101	Major Facilitator Superfamily; Region: MFS_1; pfam07690
565040000102	putative substrate translocation pore; other site
565040000103	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040000104	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040000105	DNA binding site [nucleotide binding]
565040000106	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040000107	dimerization interface [polypeptide binding]; other site
565040000108	ligand binding site [chemical binding]; other site
565040000109	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
565040000110	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
565040000111	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
565040000112	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
565040000113	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
565040000114	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
565040000115	Na binding site [ion binding]; other site
565040000116	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
565040000117	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
565040000118	active site
565040000119	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
565040000120	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
565040000121	active site
565040000122	HIGH motif; other site
565040000123	dimer interface [polypeptide binding]; other site
565040000124	KMSKS motif; other site
565040000125	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
565040000126	homodimer interface [polypeptide binding]; other site
565040000127	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
565040000128	active site pocket [active]
565040000129	Rhomboid family; Region: Rhomboid; pfam01694
565040000130	putative septation inhibitor protein; Reviewed; Region: PRK02251
565040000131	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
565040000132	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
565040000133	active site
565040000134	catalytic site [active]
565040000135	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
565040000136	Glutamine amidotransferase class-I; Region: GATase; pfam00117
565040000137	glutamine binding [chemical binding]; other site
565040000138	catalytic triad [active]
565040000139	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
565040000140	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
565040000141	active site
565040000142	ATP binding site [chemical binding]; other site
565040000143	substrate binding site [chemical binding]; other site
565040000144	activation loop (A-loop); other site
565040000145	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
565040000146	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
565040000147	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
565040000148	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
565040000149	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
565040000150	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
565040000151	active site
565040000152	ATP binding site [chemical binding]; other site
565040000153	substrate binding site [chemical binding]; other site
565040000154	activation loop (A-loop); other site
565040000155	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
565040000156	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
565040000157	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
565040000158	active site
565040000159	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
565040000160	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
565040000161	phosphopeptide binding site; other site
565040000162	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
565040000163	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
565040000164	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
565040000165	phosphopeptide binding site; other site
565040000166	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
565040000167	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
565040000168	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
565040000169	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
565040000170	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
565040000171	metal ion-dependent adhesion site (MIDAS); other site
565040000172	potential frameshift: common BLAST hit: gi|312133569|ref|YP_004000908.1| protein
565040000173	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
565040000174	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
565040000175	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
565040000176	putative dimer interface [polypeptide binding]; other site
565040000177	aromatic amino acid exporter; Provisional; Region: PRK11689
565040000178	Putative esterase; Region: Esterase; pfam00756
565040000179	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
565040000180	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
565040000181	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
565040000182	methionine sulfoxide reductase B; Provisional; Region: PRK00222
565040000183	SelR domain; Region: SelR; pfam01641
565040000184	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
565040000185	PLD-like domain; Region: PLDc_2; pfam13091
565040000186	putative homodimer interface [polypeptide binding]; other site
565040000187	putative active site [active]
565040000188	catalytic site [active]
565040000189	DEAD-like helicases superfamily; Region: DEXDc; smart00487
565040000190	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
565040000191	ATP binding site [chemical binding]; other site
565040000192	putative Mg++ binding site [ion binding]; other site
565040000193	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
565040000194	nucleotide binding region [chemical binding]; other site
565040000195	ATP-binding site [chemical binding]; other site
565040000196	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
565040000197	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
565040000198	active site
565040000199	8-oxo-dGMP binding site [chemical binding]; other site
565040000200	nudix motif; other site
565040000201	metal binding site [ion binding]; metal-binding site
565040000202	hypothetical protein; Provisional; Region: PRK01119
565040000203	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
565040000204	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
565040000205	Coenzyme A binding pocket [chemical binding]; other site
565040000206	Haemolysin-III related; Region: HlyIII; pfam03006
565040000207	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
565040000208	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
565040000209	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
565040000210	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
565040000211	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
565040000212	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
565040000213	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
565040000214	Soluble P-type ATPase [General function prediction only]; Region: COG4087
565040000215	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
565040000216	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040000217	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040000218	Integrase core domain; Region: rve; pfam00665
565040000219	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
565040000220	ferredoxin-NADP+ reductase; Region: PLN02852
565040000221	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
565040000222	heat shock protein HtpX; Provisional; Region: PRK03072
565040000223	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
565040000224	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
565040000225	active site
565040000226	intersubunit interface [polypeptide binding]; other site
565040000227	zinc binding site [ion binding]; other site
565040000228	Na+ binding site [ion binding]; other site
565040000229	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
565040000230	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
565040000231	GDP-binding site [chemical binding]; other site
565040000232	ACT binding site; other site
565040000233	IMP binding site; other site
565040000234	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
565040000235	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
565040000236	Cl- selectivity filter; other site
565040000237	Cl- binding residues [ion binding]; other site
565040000238	pore gating glutamate residue; other site
565040000239	dimer interface [polypeptide binding]; other site
565040000240	H+/Cl- coupling transport residue; other site
565040000241	TrkA-C domain; Region: TrkA_C; pfam02080
565040000242	CrcB-like protein; Region: CRCB; pfam02537
565040000243	CrcB-like protein; Region: CRCB; pfam02537
565040000244	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040000245	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040000246	DNA binding site [nucleotide binding]
565040000247	domain linker motif; other site
565040000248	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
565040000249	K+ potassium transporter; Region: K_trans; pfam02705
565040000250	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
565040000251	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
565040000252	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040000253	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040000254	DNA binding site [nucleotide binding]
565040000255	domain linker motif; other site
565040000256	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040000257	dimerization interface [polypeptide binding]; other site
565040000258	ligand binding site [chemical binding]; other site
565040000259	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
565040000260	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040000261	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040000262	Integrase core domain; Region: rve; pfam00665
565040000263	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
565040000264	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040000265	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
565040000266	Int/Topo IB signature motif; other site
565040000267	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040000268	active site
565040000269	DNA binding site [nucleotide binding]
565040000270	Int/Topo IB signature motif; other site
565040000271	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
565040000272	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040000273	active site
565040000274	DNA binding site [nucleotide binding]
565040000275	Int/Topo IB signature motif; other site
565040000276	Helix-turn-helix domain; Region: HTH_28; pfam13518
565040000277	Winged helix-turn helix; Region: HTH_29; pfam13551
565040000278	HTH-like domain; Region: HTH_21; pfam13276
565040000279	Integrase core domain; Region: rve; pfam00665
565040000280	sucrose phosphorylase; Provisional; Region: PRK13840
565040000281	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
565040000282	active site
565040000283	homodimer interface [polypeptide binding]; other site
565040000284	catalytic site [active]
565040000285	Domain of unknown function (DUF1964); Region: DUF1964; pfam09244
565040000286	Major Facilitator Superfamily; Region: MFS_1; pfam07690
565040000287	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040000288	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040000289	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040000290	DNA binding site [nucleotide binding]
565040000291	domain linker motif; other site
565040000292	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
565040000293	dimerization interface [polypeptide binding]; other site
565040000294	ligand binding site [chemical binding]; other site
565040000295	sodium binding site [ion binding]; other site
565040000296	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040000297	metabolite-proton symporter; Region: 2A0106; TIGR00883
565040000298	putative substrate translocation pore; other site
565040000299	ketol-acid reductoisomerase; Provisional; Region: PRK05479
565040000300	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
565040000301	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
565040000302	ketol-acid reductoisomerase; Provisional; Region: PRK05479
565040000303	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
565040000304	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
565040000305	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
565040000306	active site
565040000307	catalytic site [active]
565040000308	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
565040000309	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040000310	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040000311	DNA binding site [nucleotide binding]
565040000312	domain linker motif; other site
565040000313	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040000314	ligand binding site [chemical binding]; other site
565040000315	dimerization interface [polypeptide binding]; other site
565040000316	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
565040000317	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
565040000318	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
565040000319	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
565040000320	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040000321	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040000322	DNA binding site [nucleotide binding]
565040000323	domain linker motif; other site
565040000324	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040000325	ligand binding site [chemical binding]; other site
565040000326	dimerization interface [polypeptide binding]; other site
565040000327	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
565040000328	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040000329	ABC-ATPase subunit interface; other site
565040000330	putative PBP binding loops; other site
565040000331	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
565040000332	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
565040000333	putative active site [active]
565040000334	putative catalytic site [active]
565040000335	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
565040000336	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
565040000337	nucleotide binding site [chemical binding]; other site
565040000338	GrpE; Region: GrpE; pfam01025
565040000339	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
565040000340	dimer interface [polypeptide binding]; other site
565040000341	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
565040000342	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
565040000343	HSP70 interaction site [polypeptide binding]; other site
565040000344	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
565040000345	substrate binding site [polypeptide binding]; other site
565040000346	dimer interface [polypeptide binding]; other site
565040000347	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
565040000348	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
565040000349	DNA binding residues [nucleotide binding]
565040000350	putative dimer interface [polypeptide binding]; other site
565040000351	xanthine permease; Region: pbuX; TIGR03173
565040000352	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
565040000353	Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080
565040000354	Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893
565040000355	putative catalytic cysteine [active]
565040000356	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
565040000357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
565040000358	NAD(P) binding site [chemical binding]; other site
565040000359	active site
565040000360	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
565040000361	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040000362	motif II; other site
565040000363	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
565040000364	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
565040000365	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
565040000366	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
565040000367	ATP binding site [chemical binding]; other site
565040000368	Walker B motif; other site
565040000369	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
565040000370	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
565040000371	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
565040000372	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
565040000373	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
565040000374	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
565040000375	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
565040000376	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
565040000377	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040000378	Walker A motif; other site
565040000379	ATP binding site [chemical binding]; other site
565040000380	Walker B motif; other site
565040000381	arginine finger; other site
565040000382	recombination protein RecR; Reviewed; Region: recR; PRK00076
565040000383	RecR protein; Region: RecR; pfam02132
565040000384	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
565040000385	putative active site [active]
565040000386	putative metal-binding site [ion binding]; other site
565040000387	tetramer interface [polypeptide binding]; other site
565040000388	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
565040000389	active site
565040000390	catalytic site [active]
565040000391	AAA domain; Region: AAA_14; pfam13173
565040000392	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
565040000393	aspartate kinase; Reviewed; Region: PRK06635
565040000394	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
565040000395	putative nucleotide binding site [chemical binding]; other site
565040000396	putative catalytic residues [active]
565040000397	putative Mg ion binding site [ion binding]; other site
565040000398	putative aspartate binding site [chemical binding]; other site
565040000399	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
565040000400	putative allosteric regulatory site; other site
565040000401	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
565040000402	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
565040000403	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
565040000404	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
565040000405	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
565040000406	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
565040000407	metal binding site [ion binding]; metal-binding site
565040000408	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
565040000409	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
565040000410	2-isopropylmalate synthase; Validated; Region: PRK03739
565040000411	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
565040000412	active site
565040000413	catalytic residues [active]
565040000414	metal binding site [ion binding]; metal-binding site
565040000415	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
565040000416	Transglycosylase; Region: Transgly; pfam00912
565040000417	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
565040000418	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
565040000419	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
565040000420	active site
565040000421	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
565040000422	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
565040000423	active site
565040000424	interdomain interaction site; other site
565040000425	putative metal-binding site [ion binding]; other site
565040000426	nucleotide binding site [chemical binding]; other site
565040000427	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
565040000428	domain I; other site
565040000429	phosphate binding site [ion binding]; other site
565040000430	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
565040000431	domain II; other site
565040000432	domain III; other site
565040000433	nucleotide binding site [chemical binding]; other site
565040000434	DNA binding groove [nucleotide binding]
565040000435	catalytic site [active]
565040000436	domain IV; other site
565040000437	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
565040000438	thymidylate kinase; Validated; Region: tmk; PRK00698
565040000439	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
565040000440	TMP-binding site; other site
565040000441	ATP-binding site [chemical binding]; other site
565040000442	DNA polymerase III subunit delta'; Validated; Region: PRK07940
565040000443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040000444	Walker A motif; other site
565040000445	ATP binding site [chemical binding]; other site
565040000446	Walker B motif; other site
565040000447	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
565040000448	substrate binding site [chemical binding]; other site
565040000449	Peptidase family C69; Region: Peptidase_C69; pfam03577
565040000450	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
565040000451	Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759
565040000452	macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450
565040000453	Predicted membrane protein [Function unknown]; Region: COG2246
565040000454	GtrA-like protein; Region: GtrA; pfam04138
565040000455	Major Facilitator Superfamily; Region: MFS_1; pfam07690
565040000456	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
565040000457	catalytic core [active]
565040000458	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
565040000459	active site
565040000460	phosphate binding residues; other site
565040000461	catalytic residues [active]
565040000462	Predicted membrane protein [Function unknown]; Region: COG3152
565040000463	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
565040000464	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
565040000465	HIGH motif; other site
565040000466	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
565040000467	active site
565040000468	KMSKS motif; other site
565040000469	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
565040000470	Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905
565040000471	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
565040000472	sugar binding site [chemical binding]; other site
565040000473	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
565040000474	Iron permease FTR1 family; Region: FTR1; cl00475
565040000475	Fe2+ transport protein; Region: Iron_transport; pfam10634
565040000476	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
565040000477	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
565040000478	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
565040000479	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
565040000480	FtsX-like permease family; Region: FtsX; pfam02687
565040000481	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
565040000482	FtsX-like permease family; Region: FtsX; pfam02687
565040000483	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
565040000484	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
565040000485	Walker A/P-loop; other site
565040000486	ATP binding site [chemical binding]; other site
565040000487	Q-loop/lid; other site
565040000488	ABC transporter signature motif; other site
565040000489	Walker B; other site
565040000490	D-loop; other site
565040000491	H-loop/switch region; other site
565040000492	FMN-binding domain; Region: FMN_bind; cl01081
565040000493	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
565040000494	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
565040000495	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
565040000496	Predicted membrane protein [Function unknown]; Region: COG1511
565040000497	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
565040000498	Predicted membrane protein [Function unknown]; Region: COG1511
565040000499	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
565040000500	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
565040000501	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
565040000502	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
565040000503	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
565040000504	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
565040000505	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
565040000506	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
565040000507	putative active site [active]
565040000508	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
565040000509	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
565040000510	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
565040000511	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
565040000512	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
565040000513	Peptidase family C69; Region: Peptidase_C69; pfam03577
565040000514	putative glycosyl transferase; Provisional; Region: PRK10073
565040000515	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
565040000516	active site
565040000517	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
565040000518	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
565040000519	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
565040000520	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
565040000521	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
565040000522	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
565040000523	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
565040000524	Nitrogen regulatory protein P-II; Region: P-II; smart00938
565040000525	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
565040000526	metal binding triad; other site
565040000527	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
565040000528	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
565040000529	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
565040000530	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
565040000531	replicative DNA helicase; Region: DnaB; TIGR00665
565040000532	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
565040000533	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
565040000534	Walker A motif; other site
565040000535	ATP binding site [chemical binding]; other site
565040000536	Walker B motif; other site
565040000537	DNA binding loops [nucleotide binding]
565040000538	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
565040000539	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
565040000540	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
565040000541	catalytic triad [active]
565040000542	Uncharacterized conserved protein [Function unknown]; Region: COG3937
565040000543	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
565040000544	ABC1 family; Region: ABC1; cl17513
565040000545	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690
565040000546	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040000547	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040000548	DNA binding site [nucleotide binding]
565040000549	domain linker motif; other site
565040000550	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040000551	dimerization interface [polypeptide binding]; other site
565040000552	ligand binding site [chemical binding]; other site
565040000553	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
565040000554	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
565040000555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040000556	dimer interface [polypeptide binding]; other site
565040000557	conserved gate region; other site
565040000558	putative PBP binding loops; other site
565040000559	ABC-ATPase subunit interface; other site
565040000560	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
565040000561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040000562	dimer interface [polypeptide binding]; other site
565040000563	conserved gate region; other site
565040000564	putative PBP binding loops; other site
565040000565	ABC-ATPase subunit interface; other site
565040000566	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
565040000567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
565040000568	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
565040000569	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
565040000570	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
565040000571	Tropomyosin like; Region: Tropomyosin_1; pfam12718
565040000572	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
565040000573	substrate binding site [chemical binding]; other site
565040000574	active site
565040000575	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
565040000576	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
565040000577	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
565040000578	catalytic residue [active]
565040000579	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
565040000580	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
565040000581	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
565040000582	active site
565040000583	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
565040000584	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
565040000585	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
565040000586	dimer interface [polypeptide binding]; other site
565040000587	ssDNA binding site [nucleotide binding]; other site
565040000588	tetramer (dimer of dimers) interface [polypeptide binding]; other site
565040000589	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
565040000590	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
565040000591	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
565040000592	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
565040000593	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
565040000594	dimerization domain swap beta strand [polypeptide binding]; other site
565040000595	regulatory protein interface [polypeptide binding]; other site
565040000596	active site
565040000597	regulatory phosphorylation site [posttranslational modification]; other site
565040000598	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
565040000599	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
565040000600	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
565040000601	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
565040000602	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
565040000603	amphipathic channel; other site
565040000604	Asn-Pro-Ala signature motifs; other site
565040000605	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
565040000606	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
565040000607	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
565040000608	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040000609	active site
565040000610	motif I; other site
565040000611	motif II; other site
565040000612	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
565040000613	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
565040000614	putative homodimer interface [polypeptide binding]; other site
565040000615	putative homotetramer interface [polypeptide binding]; other site
565040000616	putative allosteric switch controlling residues; other site
565040000617	putative metal binding site [ion binding]; other site
565040000618	putative homodimer-homodimer interface [polypeptide binding]; other site
565040000619	RmuC family; Region: RmuC; pfam02646
565040000620	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
565040000621	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
565040000622	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
565040000623	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
565040000624	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
565040000625	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
565040000626	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
565040000627	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
565040000628	GatB domain; Region: GatB_Yqey; pfam02637
565040000629	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
565040000630	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
565040000631	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
565040000632	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
565040000633	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
565040000634	hypothetical protein; Provisional; Region: PRK07208
565040000635	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
565040000636	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
565040000637	transcription termination factor Rho; Provisional; Region: PRK12608
565040000638	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
565040000639	RNA binding site [nucleotide binding]; other site
565040000640	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
565040000641	multimer interface [polypeptide binding]; other site
565040000642	Walker A motif; other site
565040000643	ATP binding site [chemical binding]; other site
565040000644	Walker B motif; other site
565040000645	monofunctional chorismate mutase, alpha proteobacterial type; Region: CM_mono_cladeE; TIGR01795
565040000646	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
565040000647	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
565040000648	active site
565040000649	HIGH motif; other site
565040000650	nucleotide binding site [chemical binding]; other site
565040000651	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
565040000652	active site
565040000653	KMSKS motif; other site
565040000654	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
565040000655	tRNA binding surface [nucleotide binding]; other site
565040000656	anticodon binding site; other site
565040000657	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
565040000658	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
565040000659	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
565040000660	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
565040000661	minor groove reading motif; other site
565040000662	helix-hairpin-helix signature motif; other site
565040000663	substrate binding pocket [chemical binding]; other site
565040000664	active site
565040000665	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
565040000666	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
565040000667	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
565040000668	DNA binding site [nucleotide binding]
565040000669	Predicted membrane protein [Function unknown]; Region: COG1971
565040000670	Domain of unknown function DUF; Region: DUF204; pfam02659
565040000671	Domain of unknown function DUF; Region: DUF204; pfam02659
565040000672	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
565040000673	dimer interface [polypeptide binding]; other site
565040000674	substrate binding site [chemical binding]; other site
565040000675	metal binding sites [ion binding]; metal-binding site
565040000676	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
565040000677	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
565040000678	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
565040000679	active site
565040000680	homodimer interface [polypeptide binding]; other site
565040000681	catalytic site [active]
565040000682	acceptor binding site [chemical binding]; other site
565040000683	homoserine O-succinyltransferase; Provisional; Region: PRK05368
565040000684	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
565040000685	proposed active site lysine [active]
565040000686	conserved cys residue [active]
565040000687	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
565040000688	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
565040000689	ATP synthase subunit C; Region: ATP-synt_C; cl00466
565040000690	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
565040000691	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
565040000692	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
565040000693	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
565040000694	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
565040000695	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
565040000696	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
565040000697	beta subunit interaction interface [polypeptide binding]; other site
565040000698	Walker A motif; other site
565040000699	ATP binding site [chemical binding]; other site
565040000700	Walker B motif; other site
565040000701	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
565040000702	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
565040000703	core domain interface [polypeptide binding]; other site
565040000704	delta subunit interface [polypeptide binding]; other site
565040000705	epsilon subunit interface [polypeptide binding]; other site
565040000706	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
565040000707	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
565040000708	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
565040000709	alpha subunit interaction interface [polypeptide binding]; other site
565040000710	Walker A motif; other site
565040000711	ATP binding site [chemical binding]; other site
565040000712	Walker B motif; other site
565040000713	inhibitor binding site; inhibition site
565040000714	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
565040000715	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
565040000716	gamma subunit interface [polypeptide binding]; other site
565040000717	epsilon subunit interface [polypeptide binding]; other site
565040000718	LBP interface [polypeptide binding]; other site
565040000719	hypothetical protein; Provisional; Region: PRK03298
565040000720	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
565040000721	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
565040000722	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
565040000723	putative active site [active]
565040000724	putative metal binding residues [ion binding]; other site
565040000725	signature motif; other site
565040000726	putative dimer interface [polypeptide binding]; other site
565040000727	putative phosphate binding site [ion binding]; other site
565040000728	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
565040000729	homotrimer interaction site [polypeptide binding]; other site
565040000730	putative active site [active]
565040000731	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
565040000732	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
565040000733	putative acyl-acceptor binding pocket; other site
565040000734	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
565040000735	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
565040000736	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
565040000737	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
565040000738	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
565040000739	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
565040000740	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
565040000741	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
565040000742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
565040000743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040000744	dimer interface [polypeptide binding]; other site
565040000745	conserved gate region; other site
565040000746	putative PBP binding loops; other site
565040000747	ABC-ATPase subunit interface; other site
565040000748	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
565040000749	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040000750	Walker A/P-loop; other site
565040000751	ATP binding site [chemical binding]; other site
565040000752	Q-loop/lid; other site
565040000753	ABC transporter signature motif; other site
565040000754	Walker B; other site
565040000755	D-loop; other site
565040000756	H-loop/switch region; other site
565040000757	TOBE domain; Region: TOBE_2; pfam08402
565040000758	CAAX protease self-immunity; Region: Abi; pfam02517
565040000759	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
565040000760	Mechanosensitive ion channel; Region: MS_channel; pfam00924
565040000761	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
565040000762	Aspartase; Region: Aspartase; cd01357
565040000763	active sites [active]
565040000764	tetramer interface [polypeptide binding]; other site
565040000765	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
565040000766	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
565040000767	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
565040000768	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
565040000769	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
565040000770	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
565040000771	DNA binding site [nucleotide binding]
565040000772	active site
565040000773	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
565040000774	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040000775	putative substrate translocation pore; other site
565040000776	YegV-like sugar kinase.  Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944
565040000777	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
565040000778	substrate binding site [chemical binding]; other site
565040000779	ATP binding site [chemical binding]; other site
565040000780	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
565040000781	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
565040000782	ssDNA binding site; other site
565040000783	generic binding surface II; other site
565040000784	DEAD-like helicases superfamily; Region: DEXDc; smart00487
565040000785	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
565040000786	ATP binding site [chemical binding]; other site
565040000787	putative Mg++ binding site [ion binding]; other site
565040000788	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
565040000789	nucleotide binding region [chemical binding]; other site
565040000790	ATP-binding site [chemical binding]; other site
565040000791	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
565040000792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
565040000793	S-adenosylmethionine binding site [chemical binding]; other site
565040000794	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
565040000795	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
565040000796	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
565040000797	Peptidase family U32; Region: Peptidase_U32; pfam01136
565040000798	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
565040000799	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
565040000800	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
565040000801	substrate binding site; other site
565040000802	dimer interface; other site
565040000803	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
565040000804	putative substrate binding pocket [chemical binding]; other site
565040000805	AC domain interface; other site
565040000806	catalytic triad [active]
565040000807	AB domain interface; other site
565040000808	interchain disulfide; other site
565040000809	DivIVA protein; Region: DivIVA; pfam05103
565040000810	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
565040000811	trimer interface [polypeptide binding]; other site
565040000812	active site
565040000813	G bulge; other site
565040000814	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
565040000815	trimer interface [polypeptide binding]; other site
565040000816	active site
565040000817	G bulge; other site
565040000818	MarC family integral membrane protein; Region: MarC; cl00919
565040000819	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040000820	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040000821	DNA binding site [nucleotide binding]
565040000822	domain linker motif; other site
565040000823	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040000824	dimerization interface [polypeptide binding]; other site
565040000825	ligand binding site [chemical binding]; other site
565040000826	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
565040000827	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
565040000828	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
565040000829	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040000830	dimer interface [polypeptide binding]; other site
565040000831	conserved gate region; other site
565040000832	putative PBP binding loops; other site
565040000833	ABC-ATPase subunit interface; other site
565040000834	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
565040000835	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040000836	dimer interface [polypeptide binding]; other site
565040000837	conserved gate region; other site
565040000838	putative PBP binding loops; other site
565040000839	ABC-ATPase subunit interface; other site
565040000840	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
565040000841	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
565040000842	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
565040000843	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
565040000844	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
565040000845	EamA-like transporter family; Region: EamA; pfam00892
565040000846	EamA-like transporter family; Region: EamA; pfam00892
565040000847	beta-phosphoglucomutase; Region: bPGM; TIGR01990
565040000848	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040000849	active site
565040000850	motif I; other site
565040000851	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
565040000852	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
565040000853	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
565040000854	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
565040000855	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
565040000856	Domain of unknown function (DUF386); Region: DUF386; cl01047
565040000857	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
565040000858	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
565040000859	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
565040000860	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
565040000861	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
565040000862	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
565040000863	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
565040000864	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
565040000865	dimer interface [polypeptide binding]; other site
565040000866	phosphorylation site [posttranslational modification]
565040000867	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
565040000868	ATP binding site [chemical binding]; other site
565040000869	Mg2+ binding site [ion binding]; other site
565040000870	G-X-G motif; other site
565040000871	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
565040000872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
565040000873	active site
565040000874	phosphorylation site [posttranslational modification]
565040000875	intermolecular recognition site; other site
565040000876	dimerization interface [polypeptide binding]; other site
565040000877	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
565040000878	DNA binding site [nucleotide binding]
565040000879	PBP superfamily domain; Region: PBP_like_2; cl17296
565040000880	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
565040000881	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040000882	dimer interface [polypeptide binding]; other site
565040000883	conserved gate region; other site
565040000884	putative PBP binding loops; other site
565040000885	ABC-ATPase subunit interface; other site
565040000886	sulfate transport protein; Provisional; Region: cysT; CHL00187
565040000887	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040000888	dimer interface [polypeptide binding]; other site
565040000889	conserved gate region; other site
565040000890	putative PBP binding loops; other site
565040000891	ABC-ATPase subunit interface; other site
565040000892	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
565040000893	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
565040000894	Walker A/P-loop; other site
565040000895	ATP binding site [chemical binding]; other site
565040000896	Q-loop/lid; other site
565040000897	ABC transporter signature motif; other site
565040000898	Walker B; other site
565040000899	D-loop; other site
565040000900	H-loop/switch region; other site
565040000901	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
565040000902	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
565040000903	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
565040000904	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
565040000905	active site
565040000906	catalytic tetrad [active]
565040000907	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
565040000908	active site
565040000909	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
565040000910	RimM N-terminal domain; Region: RimM; pfam01782
565040000911	hypothetical protein; Provisional; Region: PRK02821
565040000912	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
565040000913	G-X-X-G motif; other site
565040000914	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
565040000915	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
565040000916	putative catalytic site [active]
565040000917	putative metal binding site [ion binding]; other site
565040000918	putative phosphate binding site [ion binding]; other site
565040000919	signal recognition particle protein; Provisional; Region: PRK10867
565040000920	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
565040000921	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
565040000922	P loop; other site
565040000923	GTP binding site [chemical binding]; other site
565040000924	Signal peptide binding domain; Region: SRP_SPB; pfam02978
565040000925	Cation efflux family; Region: Cation_efflux; pfam01545
565040000926	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
565040000927	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
565040000928	active site
565040000929	HIGH motif; other site
565040000930	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
565040000931	KMSKS motif; other site
565040000932	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
565040000933	tRNA binding surface [nucleotide binding]; other site
565040000934	anticodon binding site; other site
565040000935	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
565040000936	catalytic triad [active]
565040000937	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
565040000938	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
565040000939	ABC transporter; Region: ABC_tran_2; pfam12848
565040000940	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
565040000941	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
565040000942	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
565040000943	oligomeric interface; other site
565040000944	putative active site [active]
565040000945	homodimer interface [polypeptide binding]; other site
565040000946	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
565040000947	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
565040000948	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
565040000949	putative valine binding site [chemical binding]; other site
565040000950	dimer interface [polypeptide binding]; other site
565040000951	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
565040000952	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
565040000953	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
565040000954	PYR/PP interface [polypeptide binding]; other site
565040000955	dimer interface [polypeptide binding]; other site
565040000956	TPP binding site [chemical binding]; other site
565040000957	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
565040000958	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
565040000959	TPP-binding site [chemical binding]; other site
565040000960	dimer interface [polypeptide binding]; other site
565040000961	ribonuclease III; Reviewed; Region: rnc; PRK00102
565040000962	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
565040000963	dimerization interface [polypeptide binding]; other site
565040000964	active site
565040000965	metal binding site [ion binding]; metal-binding site
565040000966	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
565040000967	dsRNA binding site [nucleotide binding]; other site
565040000968	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
565040000969	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
565040000970	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
565040000971	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
565040000972	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
565040000973	active site
565040000974	(T/H)XGH motif; other site
565040000975	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
565040000976	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
565040000977	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
565040000978	active site
565040000979	catalytic tetrad [active]
565040000980	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
565040000981	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
565040000982	DNA binding residues [nucleotide binding]
565040000983	putative dimer interface [polypeptide binding]; other site
565040000984	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
565040000985	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
565040000986	active site
565040000987	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040000988	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040000989	Integrase core domain; Region: rve; pfam00665
565040000990	ribonuclease PH; Reviewed; Region: rph; PRK00173
565040000991	Ribonuclease PH; Region: RNase_PH_bact; cd11362
565040000992	hexamer interface [polypeptide binding]; other site
565040000993	active site
565040000994	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
565040000995	active site
565040000996	dimerization interface [polypeptide binding]; other site
565040000997	FemAB family; Region: FemAB; pfam02388
565040000998	FemAB family; Region: FemAB; pfam02388
565040000999	FemAB family; Region: FemAB; pfam02388
565040001000	Membrane transport protein; Region: Mem_trans; cl09117
565040001001	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
565040001002	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
565040001003	active site
565040001004	dimer interface [polypeptide binding]; other site
565040001005	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
565040001006	dimer interface [polypeptide binding]; other site
565040001007	active site
565040001008	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
565040001009	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
565040001010	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
565040001011	Catalytic site [active]
565040001012	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
565040001013	RNA/DNA hybrid binding site [nucleotide binding]; other site
565040001014	active site
565040001015	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040001016	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040001017	DNA binding site [nucleotide binding]
565040001018	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
565040001019	ligand binding site [chemical binding]; other site
565040001020	dimerization interface (open form) [polypeptide binding]; other site
565040001021	dimerization interface (closed form) [polypeptide binding]; other site
565040001022	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
565040001023	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
565040001024	putative N- and C-terminal domain interface [polypeptide binding]; other site
565040001025	putative active site [active]
565040001026	MgATP binding site [chemical binding]; other site
565040001027	catalytic site [active]
565040001028	metal binding site [ion binding]; metal-binding site
565040001029	putative carbohydrate binding site [chemical binding]; other site
565040001030	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
565040001031	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
565040001032	intersubunit interface [polypeptide binding]; other site
565040001033	active site
565040001034	Zn2+ binding site [ion binding]; other site
565040001035	L-arabinose isomerase; Provisional; Region: PRK02929
565040001036	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
565040001037	hexamer (dimer of trimers) interface [polypeptide binding]; other site
565040001038	trimer interface [polypeptide binding]; other site
565040001039	substrate binding site [chemical binding]; other site
565040001040	Mn binding site [ion binding]; other site
565040001041	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
565040001042	Peptidase C26; Region: Peptidase_C26; pfam07722
565040001043	catalytic triad [active]
565040001044	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
565040001045	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
565040001046	FtsX-like permease family; Region: FtsX; pfam02687
565040001047	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
565040001048	FtsX-like permease family; Region: FtsX; pfam02687
565040001049	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
565040001050	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
565040001051	Walker A/P-loop; other site
565040001052	ATP binding site [chemical binding]; other site
565040001053	Q-loop/lid; other site
565040001054	ABC transporter signature motif; other site
565040001055	Walker B; other site
565040001056	D-loop; other site
565040001057	H-loop/switch region; other site
565040001058	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
565040001059	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
565040001060	acyl-activating enzyme (AAE) consensus motif; other site
565040001061	putative AMP binding site [chemical binding]; other site
565040001062	putative active site [active]
565040001063	putative CoA binding site [chemical binding]; other site
565040001064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
565040001065	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
565040001066	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
565040001067	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040001068	Walker A/P-loop; other site
565040001069	ATP binding site [chemical binding]; other site
565040001070	Q-loop/lid; other site
565040001071	ABC transporter signature motif; other site
565040001072	Walker B; other site
565040001073	D-loop; other site
565040001074	H-loop/switch region; other site
565040001075	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
565040001076	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
565040001077	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040001078	Walker A/P-loop; other site
565040001079	ATP binding site [chemical binding]; other site
565040001080	Q-loop/lid; other site
565040001081	ABC transporter signature motif; other site
565040001082	Walker B; other site
565040001083	D-loop; other site
565040001084	H-loop/switch region; other site
565040001085	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
565040001086	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
565040001087	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
565040001088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040001089	dimer interface [polypeptide binding]; other site
565040001090	conserved gate region; other site
565040001091	putative PBP binding loops; other site
565040001092	ABC-ATPase subunit interface; other site
565040001093	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
565040001094	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040001095	dimer interface [polypeptide binding]; other site
565040001096	conserved gate region; other site
565040001097	putative PBP binding loops; other site
565040001098	ABC-ATPase subunit interface; other site
565040001099	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
565040001100	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
565040001101	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
565040001102	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
565040001103	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040001104	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040001105	DNA binding site [nucleotide binding]
565040001106	domain linker motif; other site
565040001107	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040001108	ligand binding site [chemical binding]; other site
565040001109	dimerization interface [polypeptide binding]; other site
565040001110	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745
565040001111	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
565040001112	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
565040001113	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
565040001114	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
565040001115	active site
565040001116	catalytic tetrad [active]
565040001117	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
565040001118	AAA domain; Region: AAA_14; pfam13173
565040001119	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
565040001120	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
565040001121	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
565040001122	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040001123	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
565040001124	putative substrate translocation pore; other site
565040001125	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040001126	Major Facilitator Superfamily; Region: MFS_1; pfam07690
565040001127	potential frameshift: common BLAST hit: gi|219683097|ref|YP_002469480.1| methyl-accepting chemotaxis protein
565040001128	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
565040001129	potential frameshift: common BLAST hit: gi|219683097|ref|YP_002469480.1| methyl-accepting chemotaxis protein
565040001130	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
565040001131	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
565040001132	Bacterial sugar transferase; Region: Bac_transf; pfam02397
565040001133	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040001134	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040001135	Integrase core domain; Region: rve; pfam00665
565040001136	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
565040001137	Integrase core domain; Region: rve; pfam00665
565040001138	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040001139	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
565040001140	Walker A motif; other site
565040001141	ATP binding site [chemical binding]; other site
565040001142	Walker B motif; other site
565040001143	arginine finger; other site
565040001144	HTH-like domain; Region: HTH_21; pfam13276
565040001145	Integrase core domain; Region: rve; pfam00665
565040001146	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040001147	active site
565040001148	DNA binding site [nucleotide binding]
565040001149	Int/Topo IB signature motif; other site
565040001150	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
565040001151	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040001152	active site
565040001153	DNA binding site [nucleotide binding]
565040001154	Int/Topo IB signature motif; other site
565040001155	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
565040001156	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040001157	Walker A motif; other site
565040001158	ATP binding site [chemical binding]; other site
565040001159	Walker B motif; other site
565040001160	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
565040001161	Integrase core domain; Region: rve; pfam00665
565040001162	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
565040001163	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
565040001164	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
565040001165	dimer interface [polypeptide binding]; other site
565040001166	tetramer interface [polypeptide binding]; other site
565040001167	PYR/PP interface [polypeptide binding]; other site
565040001168	TPP binding site [chemical binding]; other site
565040001169	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
565040001170	TPP-binding site [chemical binding]; other site
565040001171	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
565040001172	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
565040001173	putative ADP-binding pocket [chemical binding]; other site
565040001174	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
565040001175	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
565040001176	putative ADP-binding pocket [chemical binding]; other site
565040001177	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
565040001178	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040001179	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040001180	Integrase core domain; Region: rve; pfam00665
565040001181	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
565040001182	Acyltransferase family; Region: Acyl_transf_3; pfam01757
565040001183	sporadically distributed protein, TIGR04141 family; Region: TIGR04141
565040001184	HTH-like domain; Region: HTH_21; pfam13276
565040001185	Integrase core domain; Region: rve; pfam00665
565040001186	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
565040001187	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040001188	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
565040001189	Int/Topo IB signature motif; other site
565040001190	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040001191	active site
565040001192	DNA binding site [nucleotide binding]
565040001193	Int/Topo IB signature motif; other site
565040001194	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
565040001195	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040001196	Walker A motif; other site
565040001197	ATP binding site [chemical binding]; other site
565040001198	Walker B motif; other site
565040001199	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
565040001200	Integrase core domain; Region: rve; pfam00665
565040001201	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
565040001202	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040001203	active site
565040001204	DNA binding site [nucleotide binding]
565040001205	Int/Topo IB signature motif; other site
565040001206	Integrase core domain; Region: rve; pfam00665
565040001207	Chain length determinant protein; Region: Wzz; cl15801
565040001208	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
565040001209	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
565040001210	Nucleotide binding site [chemical binding]; other site
565040001211	DTAP/Switch II; other site
565040001212	Switch I; other site
565040001213	Domain of unknown function (DUF348); Region: DUF348; pfam03990
565040001214	G5 domain; Region: G5; pfam07501
565040001215	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
565040001216	N-acetyl-D-glucosamine binding site [chemical binding]; other site
565040001217	catalytic residue [active]
565040001218	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
565040001219	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
565040001220	catalytic residues [active]
565040001221	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
565040001222	nudix motif; other site
565040001223	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
565040001224	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
565040001225	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
565040001226	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
565040001227	putative NADH binding site [chemical binding]; other site
565040001228	putative active site [active]
565040001229	nudix motif; other site
565040001230	putative metal binding site [ion binding]; other site
565040001231	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
565040001232	lipoyl attachment site [posttranslational modification]; other site
565040001233	Uncharacterized conserved protein [Function unknown]; Region: COG4850
565040001234	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
565040001235	Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897
565040001236	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
565040001237	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
565040001238	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
565040001239	tartrate dehydrogenase; Region: TTC; TIGR02089
565040001240	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
565040001241	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
565040001242	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
565040001243	ligand binding site [chemical binding]; other site
565040001244	flexible hinge region; other site
565040001245	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
565040001246	putative switch regulator; other site
565040001247	non-specific DNA interactions [nucleotide binding]; other site
565040001248	DNA binding site [nucleotide binding]
565040001249	sequence specific DNA binding site [nucleotide binding]; other site
565040001250	putative cAMP binding site [chemical binding]; other site
565040001251	Transglycosylase; Region: Transgly; pfam00912
565040001252	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
565040001253	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
565040001254	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
565040001255	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
565040001256	active site
565040001257	FMN binding site [chemical binding]; other site
565040001258	substrate binding site [chemical binding]; other site
565040001259	homotetramer interface [polypeptide binding]; other site
565040001260	catalytic residue [active]
565040001261	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
565040001262	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
565040001263	quinone interaction residues [chemical binding]; other site
565040001264	active site
565040001265	catalytic residues [active]
565040001266	FMN binding site [chemical binding]; other site
565040001267	substrate binding site [chemical binding]; other site
565040001268	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
565040001269	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
565040001270	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
565040001271	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
565040001272	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
565040001273	dimer interface [polypeptide binding]; other site
565040001274	active site
565040001275	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
565040001276	galactokinase; Provisional; Region: PRK05322
565040001277	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
565040001278	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
565040001279	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
565040001280	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
565040001281	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
565040001282	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
565040001283	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
565040001284	minor groove reading motif; other site
565040001285	helix-hairpin-helix signature motif; other site
565040001286	active site
565040001287	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
565040001288	Alphaherpesvirus tegument protein US9; Region: Herpes_US9; pfam06072
565040001289	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
565040001290	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
565040001291	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
565040001292	RPB1 interaction site [polypeptide binding]; other site
565040001293	RPB10 interaction site [polypeptide binding]; other site
565040001294	RPB11 interaction site [polypeptide binding]; other site
565040001295	RPB3 interaction site [polypeptide binding]; other site
565040001296	RPB12 interaction site [polypeptide binding]; other site
565040001297	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
565040001298	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
565040001299	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
565040001300	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
565040001301	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
565040001302	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
565040001303	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
565040001304	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
565040001305	DNA binding site [nucleotide binding]
565040001306	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
565040001307	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
565040001308	phosphopeptide binding site; other site
565040001309	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
565040001310	active site
565040001311	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
565040001312	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
565040001313	Protein of unknown function DUF58; Region: DUF58; pfam01882
565040001314	MoxR-like ATPases [General function prediction only]; Region: COG0714
565040001315	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040001316	Walker A motif; other site
565040001317	ATP binding site [chemical binding]; other site
565040001318	Walker B motif; other site
565040001319	arginine finger; other site
565040001320	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
565040001321	Interdomain contacts; other site
565040001322	Cytokine receptor motif; other site
565040001323	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
565040001324	Interdomain contacts; other site
565040001325	Cytokine receptor motif; other site
565040001326	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
565040001327	Catalytic domain of Protein Kinases; Region: PKc; cd00180
565040001328	active site
565040001329	ATP binding site [chemical binding]; other site
565040001330	substrate binding site [chemical binding]; other site
565040001331	activation loop (A-loop); other site
565040001332	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
565040001333	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
565040001334	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
565040001335	Family description; Region: UvrD_C_2; pfam13538
565040001336	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
565040001337	Major Facilitator Superfamily; Region: MFS_1; pfam07690
565040001338	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040001339	dihydrodipicolinate reductase; Provisional; Region: PRK00048
565040001340	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
565040001341	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
565040001342	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
565040001343	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
565040001344	dimer interface [polypeptide binding]; other site
565040001345	active site
565040001346	catalytic residue [active]
565040001347	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
565040001348	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
565040001349	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
565040001350	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
565040001351	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
565040001352	Zn binding site [ion binding]; other site
565040001353	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
565040001354	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
565040001355	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
565040001356	active site
565040001357	substrate binding site [chemical binding]; other site
565040001358	metal binding site [ion binding]; metal-binding site
565040001359	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
565040001360	active site
565040001361	catalytic residues [active]
565040001362	metal binding site [ion binding]; metal-binding site
565040001363	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
565040001364	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
565040001365	active site
565040001366	substrate binding site [chemical binding]; other site
565040001367	catalytic site [active]
565040001368	peptide chain release factor 2; Validated; Region: prfB; PRK00578
565040001369	This domain is found in peptide chain release factors; Region: PCRF; smart00937
565040001370	RF-1 domain; Region: RF-1; pfam00472
565040001371	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
565040001372	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040001373	Walker A/P-loop; other site
565040001374	ATP binding site [chemical binding]; other site
565040001375	Q-loop/lid; other site
565040001376	ABC transporter signature motif; other site
565040001377	Walker B; other site
565040001378	D-loop; other site
565040001379	H-loop/switch region; other site
565040001380	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
565040001381	FtsX-like permease family; Region: FtsX; pfam02687
565040001382	Surface antigen [General function prediction only]; Region: COG3942
565040001383	CHAP domain; Region: CHAP; pfam05257
565040001384	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
565040001385	SmpB-tmRNA interface; other site
565040001386	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
565040001387	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
565040001388	substrate binding pocket [chemical binding]; other site
565040001389	membrane-bound complex binding site; other site
565040001390	hinge residues; other site
565040001391	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
565040001392	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
565040001393	substrate binding pocket [chemical binding]; other site
565040001394	membrane-bound complex binding site; other site
565040001395	hinge residues; other site
565040001396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040001397	dimer interface [polypeptide binding]; other site
565040001398	conserved gate region; other site
565040001399	putative PBP binding loops; other site
565040001400	ABC-ATPase subunit interface; other site
565040001401	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
565040001402	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
565040001403	Walker A/P-loop; other site
565040001404	ATP binding site [chemical binding]; other site
565040001405	Q-loop/lid; other site
565040001406	ABC transporter signature motif; other site
565040001407	Walker B; other site
565040001408	D-loop; other site
565040001409	H-loop/switch region; other site
565040001410	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
565040001411	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
565040001412	glutaminase active site [active]
565040001413	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
565040001414	dimer interface [polypeptide binding]; other site
565040001415	active site
565040001416	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
565040001417	dimer interface [polypeptide binding]; other site
565040001418	active site
565040001419	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
565040001420	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
565040001421	active site
565040001422	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
565040001423	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040001424	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040001425	DNA binding site [nucleotide binding]
565040001426	domain linker motif; other site
565040001427	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
565040001428	ligand binding site [chemical binding]; other site
565040001429	dimerization interface (open form) [polypeptide binding]; other site
565040001430	dimerization interface (closed form) [polypeptide binding]; other site
565040001431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040001432	dimer interface [polypeptide binding]; other site
565040001433	conserved gate region; other site
565040001434	putative PBP binding loops; other site
565040001435	ABC-ATPase subunit interface; other site
565040001436	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
565040001437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040001438	dimer interface [polypeptide binding]; other site
565040001439	conserved gate region; other site
565040001440	putative PBP binding loops; other site
565040001441	ABC-ATPase subunit interface; other site
565040001442	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
565040001443	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
565040001444	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
565040001445	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040001446	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040001447	DNA binding site [nucleotide binding]
565040001448	domain linker motif; other site
565040001449	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040001450	ligand binding site [chemical binding]; other site
565040001451	dimerization interface [polypeptide binding]; other site
565040001452	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
565040001453	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
565040001454	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
565040001455	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
565040001456	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
565040001457	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
565040001458	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
565040001459	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
565040001460	pantothenate kinase; Reviewed; Region: PRK13318
565040001461	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
565040001462	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
565040001463	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
565040001464	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040001465	putative PBP binding loops; other site
565040001466	dimer interface [polypeptide binding]; other site
565040001467	ABC-ATPase subunit interface; other site
565040001468	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
565040001469	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040001470	ABC-ATPase subunit interface; other site
565040001471	putative PBP binding loops; other site
565040001472	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
565040001473	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
565040001474	Walker A/P-loop; other site
565040001475	ATP binding site [chemical binding]; other site
565040001476	Q-loop/lid; other site
565040001477	ABC transporter signature motif; other site
565040001478	Walker B; other site
565040001479	D-loop; other site
565040001480	H-loop/switch region; other site
565040001481	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
565040001482	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
565040001483	Walker A/P-loop; other site
565040001484	ATP binding site [chemical binding]; other site
565040001485	Q-loop/lid; other site
565040001486	ABC transporter signature motif; other site
565040001487	Walker B; other site
565040001488	D-loop; other site
565040001489	H-loop/switch region; other site
565040001490	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
565040001491	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
565040001492	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
565040001493	dimer interface [polypeptide binding]; other site
565040001494	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040001495	catalytic residue [active]
565040001496	cystathionine gamma-synthase; Provisional; Region: PRK07811
565040001497	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
565040001498	homodimer interface [polypeptide binding]; other site
565040001499	substrate-cofactor binding pocket; other site
565040001500	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040001501	catalytic residue [active]
565040001502	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
565040001503	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
565040001504	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
565040001505	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
565040001506	ATP binding site [chemical binding]; other site
565040001507	putative Mg++ binding site [ion binding]; other site
565040001508	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
565040001509	nucleotide binding region [chemical binding]; other site
565040001510	ATP-binding site [chemical binding]; other site
565040001511	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
565040001512	HRDC domain; Region: HRDC; pfam00570
565040001513	S-ribosylhomocysteinase; Provisional; Region: PRK02260
565040001514	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
565040001515	amino acid transporter; Region: 2A0306; TIGR00909
565040001516	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
565040001517	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
565040001518	alanine racemase; Reviewed; Region: alr; PRK00053
565040001519	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
565040001520	active site
565040001521	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
565040001522	dimer interface [polypeptide binding]; other site
565040001523	substrate binding site [chemical binding]; other site
565040001524	catalytic residues [active]
565040001525	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
565040001526	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
565040001527	Zn2+ binding site [ion binding]; other site
565040001528	Mg2+ binding site [ion binding]; other site
565040001529	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
565040001530	DNA primase, catalytic core; Region: dnaG; TIGR01391
565040001531	CHC2 zinc finger; Region: zf-CHC2; cl17510
565040001532	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
565040001533	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
565040001534	active site
565040001535	metal binding site [ion binding]; metal-binding site
565040001536	interdomain interaction site; other site
565040001537	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
565040001538	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040001539	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040001540	Integrase core domain; Region: rve; pfam00665
565040001541	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
565040001542	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
565040001543	active site
565040001544	multimer interface [polypeptide binding]; other site
565040001545	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152
565040001546	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
565040001547	predicted active site [active]
565040001548	catalytic triad [active]
565040001549	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
565040001550	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
565040001551	DNA-binding site [nucleotide binding]; DNA binding site
565040001552	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
565040001553	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040001554	homodimer interface [polypeptide binding]; other site
565040001555	catalytic residue [active]
565040001556	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
565040001557	catalytic nucleophile [active]
565040001558	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
565040001559	transmembrane helices; other site
565040001560	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
565040001561	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
565040001562	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
565040001563	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
565040001564	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
565040001565	putative active site [active]
565040001566	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
565040001567	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
565040001568	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
565040001569	Walker A/P-loop; other site
565040001570	ATP binding site [chemical binding]; other site
565040001571	Q-loop/lid; other site
565040001572	ABC transporter signature motif; other site
565040001573	Walker B; other site
565040001574	D-loop; other site
565040001575	H-loop/switch region; other site
565040001576	S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361
565040001577	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
565040001578	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
565040001579	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
565040001580	FtsX-like permease family; Region: FtsX; pfam02687
565040001581	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
565040001582	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
565040001583	TPP-binding site; other site
565040001584	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
565040001585	PYR/PP interface [polypeptide binding]; other site
565040001586	dimer interface [polypeptide binding]; other site
565040001587	TPP binding site [chemical binding]; other site
565040001588	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
565040001589	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
565040001590	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
565040001591	NAD(P) binding site [chemical binding]; other site
565040001592	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
565040001593	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
565040001594	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
565040001595	NAD binding site [chemical binding]; other site
565040001596	ATP-grasp domain; Region: ATP-grasp; pfam02222
565040001597	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
565040001598	metal binding site 2 [ion binding]; metal-binding site
565040001599	putative DNA binding helix; other site
565040001600	metal binding site 1 [ion binding]; metal-binding site
565040001601	dimer interface [polypeptide binding]; other site
565040001602	structural Zn2+ binding site [ion binding]; other site
565040001603	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
565040001604	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
565040001605	metal binding site [ion binding]; metal-binding site
565040001606	Sulfatase; Region: Sulfatase; pfam00884
565040001607	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
565040001608	NAD(P) binding site [chemical binding]; other site
565040001609	catalytic residues [active]
565040001610	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
565040001611	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
565040001612	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
565040001613	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
565040001614	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
565040001615	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
565040001616	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
565040001617	dimerization interface [polypeptide binding]; other site
565040001618	putative ATP binding site [chemical binding]; other site
565040001619	amidophosphoribosyltransferase; Provisional; Region: PRK07272
565040001620	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
565040001621	active site
565040001622	tetramer interface [polypeptide binding]; other site
565040001623	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
565040001624	active site
565040001625	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
565040001626	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
565040001627	Walker A/P-loop; other site
565040001628	ATP binding site [chemical binding]; other site
565040001629	Q-loop/lid; other site
565040001630	ABC transporter signature motif; other site
565040001631	Walker B; other site
565040001632	D-loop; other site
565040001633	H-loop/switch region; other site
565040001634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040001635	dimer interface [polypeptide binding]; other site
565040001636	conserved gate region; other site
565040001637	putative PBP binding loops; other site
565040001638	ABC-ATPase subunit interface; other site
565040001639	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
565040001640	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
565040001641	substrate binding pocket [chemical binding]; other site
565040001642	membrane-bound complex binding site; other site
565040001643	hinge residues; other site
565040001644	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
565040001645	guanine deaminase; Region: guan_deamin; TIGR02967
565040001646	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312
565040001647	active site
565040001648	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
565040001649	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
565040001650	NAD binding site [chemical binding]; other site
565040001651	DNA polymerase IV; Reviewed; Region: PRK03103
565040001652	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
565040001653	active site
565040001654	DNA binding site [nucleotide binding]
565040001655	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
565040001656	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
565040001657	active site
565040001658	catalytic tetrad [active]
565040001659	Transcriptional regulator [Transcription]; Region: LysR; COG0583
565040001660	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
565040001661	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
565040001662	dimerization interface [polypeptide binding]; other site
565040001663	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
565040001664	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
565040001665	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
565040001666	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
565040001667	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
565040001668	dimerization interface [polypeptide binding]; other site
565040001669	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
565040001670	dimerization interface [polypeptide binding]; other site
565040001671	ATP binding site [chemical binding]; other site
565040001672	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
565040001673	dimerization interface [polypeptide binding]; other site
565040001674	ATP binding site [chemical binding]; other site
565040001675	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
565040001676	putative active site [active]
565040001677	catalytic triad [active]
565040001678	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
565040001679	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
565040001680	ATP binding site [chemical binding]; other site
565040001681	active site
565040001682	substrate binding site [chemical binding]; other site
565040001683	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
565040001684	ATP-grasp domain; Region: ATP-grasp; pfam02222
565040001685	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
565040001686	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
565040001687	putative ADP-binding pocket [chemical binding]; other site
565040001688	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
565040001689	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
565040001690	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
565040001691	catalytic residue [active]
565040001692	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
565040001693	Sodium Bile acid symporter family; Region: SBF; pfam01758
565040001694	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040001695	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040001696	Integrase core domain; Region: rve; pfam00665
565040001697	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
565040001698	S17 interaction site [polypeptide binding]; other site
565040001699	S8 interaction site; other site
565040001700	16S rRNA interaction site [nucleotide binding]; other site
565040001701	streptomycin interaction site [chemical binding]; other site
565040001702	23S rRNA interaction site [nucleotide binding]; other site
565040001703	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
565040001704	30S ribosomal protein S7; Validated; Region: PRK05302
565040001705	elongation factor G; Reviewed; Region: PRK00007
565040001706	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
565040001707	G1 box; other site
565040001708	putative GEF interaction site [polypeptide binding]; other site
565040001709	GTP/Mg2+ binding site [chemical binding]; other site
565040001710	Switch I region; other site
565040001711	G2 box; other site
565040001712	G3 box; other site
565040001713	Switch II region; other site
565040001714	G4 box; other site
565040001715	G5 box; other site
565040001716	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
565040001717	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
565040001718	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
565040001719	elongation factor Tu; Reviewed; Region: PRK00049
565040001720	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
565040001721	G1 box; other site
565040001722	GEF interaction site [polypeptide binding]; other site
565040001723	GTP/Mg2+ binding site [chemical binding]; other site
565040001724	Switch I region; other site
565040001725	G2 box; other site
565040001726	G3 box; other site
565040001727	Switch II region; other site
565040001728	G4 box; other site
565040001729	G5 box; other site
565040001730	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
565040001731	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
565040001732	Antibiotic Binding Site [chemical binding]; other site
565040001733	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
565040001734	Transcriptional regulator [Transcription]; Region: LysR; COG0583
565040001735	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
565040001736	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
565040001737	dimerization interface [polypeptide binding]; other site
565040001738	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
565040001739	Predicted membrane protein [Function unknown]; Region: COG2246
565040001740	GtrA-like protein; Region: GtrA; pfam04138
565040001741	CrcB-like protein; Region: CRCB; pfam02537
565040001742	CrcB-like protein; Region: CRCB; pfam02537
565040001743	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
565040001744	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
565040001745	catalytic Zn binding site [ion binding]; other site
565040001746	NAD(P) binding site [chemical binding]; other site
565040001747	structural Zn binding site [ion binding]; other site
565040001748	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
565040001749	AAA domain; Region: AAA_14; pfam13173
565040001750	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
565040001751	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
565040001752	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
565040001753	MarR family; Region: MarR_2; pfam12802
565040001754	KDPG and KHG aldolase; Region: Aldolase; cl17259
565040001755	AAA domain; Region: AAA_14; pfam13173
565040001756	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
565040001757	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
565040001758	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040001759	Walker A/P-loop; other site
565040001760	ATP binding site [chemical binding]; other site
565040001761	Q-loop/lid; other site
565040001762	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
565040001763	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
565040001764	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040001765	ABC transporter signature motif; other site
565040001766	Walker B; other site
565040001767	D-loop; other site
565040001768	H-loop/switch region; other site
565040001769	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040001770	Walker A/P-loop; other site
565040001771	ATP binding site [chemical binding]; other site
565040001772	Q-loop/lid; other site
565040001773	ABC transporter signature motif; other site
565040001774	Walker B; other site
565040001775	D-loop; other site
565040001776	H-loop/switch region; other site
565040001777	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
565040001778	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
565040001779	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
565040001780	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
565040001781	minor groove reading motif; other site
565040001782	helix-hairpin-helix signature motif; other site
565040001783	active site
565040001784	potential frameshift: common BLAST hit: gi|296453782|ref|YP_003660925.1| galactoside O-acetyltransferase
565040001785	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
565040001786	active site
565040001787	substrate binding site [chemical binding]; other site
565040001788	trimer interface [polypeptide binding]; other site
565040001789	CoA binding site [chemical binding]; other site
565040001790	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
565040001791	putative CoA binding site [chemical binding]; other site
565040001792	putative trimer interface [polypeptide binding]; other site
565040001793	Predicted permeases [General function prediction only]; Region: COG0679
565040001794	glutamine synthetase, type I; Region: GlnA; TIGR00653
565040001795	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
565040001796	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
565040001797	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
565040001798	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040001799	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040001800	Integrase core domain; Region: rve; pfam00665
565040001801	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
565040001802	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
565040001803	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
565040001804	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
565040001805	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
565040001806	hypothetical protein; Provisional; Region: PRK07907
565040001807	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
565040001808	active site
565040001809	metal binding site [ion binding]; metal-binding site
565040001810	dimer interface [polypeptide binding]; other site
565040001811	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
565040001812	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
565040001813	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
565040001814	Walker A/P-loop; other site
565040001815	ATP binding site [chemical binding]; other site
565040001816	Q-loop/lid; other site
565040001817	ABC transporter signature motif; other site
565040001818	Walker B; other site
565040001819	D-loop; other site
565040001820	H-loop/switch region; other site
565040001821	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
565040001822	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
565040001823	Walker A/P-loop; other site
565040001824	ATP binding site [chemical binding]; other site
565040001825	Q-loop/lid; other site
565040001826	ABC transporter signature motif; other site
565040001827	Walker B; other site
565040001828	D-loop; other site
565040001829	H-loop/switch region; other site
565040001830	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
565040001831	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
565040001832	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
565040001833	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
565040001834	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
565040001835	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
565040001836	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
565040001837	dimer interface [polypeptide binding]; other site
565040001838	motif 1; other site
565040001839	active site
565040001840	motif 2; other site
565040001841	motif 3; other site
565040001842	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
565040001843	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
565040001844	putative tRNA-binding site [nucleotide binding]; other site
565040001845	B3/4 domain; Region: B3_4; pfam03483
565040001846	tRNA synthetase B5 domain; Region: B5; pfam03484
565040001847	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
565040001848	dimer interface [polypeptide binding]; other site
565040001849	motif 1; other site
565040001850	motif 3; other site
565040001851	motif 2; other site
565040001852	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
565040001853	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
565040001854	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
565040001855	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
565040001856	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
565040001857	heterotetramer interface [polypeptide binding]; other site
565040001858	active site pocket [active]
565040001859	cleavage site
565040001860	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
565040001861	feedback inhibition sensing region; other site
565040001862	homohexameric interface [polypeptide binding]; other site
565040001863	nucleotide binding site [chemical binding]; other site
565040001864	N-acetyl-L-glutamate binding site [chemical binding]; other site
565040001865	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
565040001866	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
565040001867	inhibitor-cofactor binding pocket; inhibition site
565040001868	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040001869	catalytic residue [active]
565040001870	ornithine carbamoyltransferase; Provisional; Region: PRK00779
565040001871	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
565040001872	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
565040001873	arginine repressor; Provisional; Region: PRK03341
565040001874	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
565040001875	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
565040001876	argininosuccinate synthase; Provisional; Region: PRK13820
565040001877	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
565040001878	ANP binding site [chemical binding]; other site
565040001879	Substrate Binding Site II [chemical binding]; other site
565040001880	Substrate Binding Site I [chemical binding]; other site
565040001881	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
565040001882	argininosuccinate lyase; Provisional; Region: PRK00855
565040001883	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
565040001884	active sites [active]
565040001885	tetramer interface [polypeptide binding]; other site
565040001886	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
565040001887	thiS-thiF/thiG interaction site; other site
565040001888	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
565040001889	ThiS interaction site; other site
565040001890	putative active site [active]
565040001891	tetramer interface [polypeptide binding]; other site
565040001892	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
565040001893	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
565040001894	ATP binding site [chemical binding]; other site
565040001895	substrate interface [chemical binding]; other site
565040001896	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
565040001897	active site residue [active]
565040001898	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
565040001899	Zn2+ binding site [ion binding]; other site
565040001900	Mg2+ binding site [ion binding]; other site
565040001901	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
565040001902	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
565040001903	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
565040001904	active site
565040001905	HIGH motif; other site
565040001906	dimer interface [polypeptide binding]; other site
565040001907	KMSKS motif; other site
565040001908	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
565040001909	RNA binding surface [nucleotide binding]; other site
565040001910	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
565040001911	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
565040001912	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
565040001913	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
565040001914	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
565040001915	RNA binding surface [nucleotide binding]; other site
565040001916	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
565040001917	S-adenosylmethionine binding site [chemical binding]; other site
565040001918	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
565040001919	TrkA-N domain; Region: TrkA_N; pfam02254
565040001920	TrkA-C domain; Region: TrkA_C; pfam02080
565040001921	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
565040001922	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
565040001923	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
565040001924	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
565040001925	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
565040001926	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
565040001927	Walker A/P-loop; other site
565040001928	ATP binding site [chemical binding]; other site
565040001929	Q-loop/lid; other site
565040001930	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
565040001931	ABC transporter signature motif; other site
565040001932	Walker B; other site
565040001933	D-loop; other site
565040001934	H-loop/switch region; other site
565040001935	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
565040001936	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040001937	motif II; other site
565040001938	Predicted transcriptional regulators [Transcription]; Region: COG1725
565040001939	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
565040001940	DNA-binding site [nucleotide binding]; DNA binding site
565040001941	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
565040001942	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
565040001943	Walker A/P-loop; other site
565040001944	ATP binding site [chemical binding]; other site
565040001945	Q-loop/lid; other site
565040001946	ABC transporter signature motif; other site
565040001947	Walker B; other site
565040001948	D-loop; other site
565040001949	H-loop/switch region; other site
565040001950	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
565040001951	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
565040001952	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
565040001953	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
565040001954	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
565040001955	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
565040001956	Soluble P-type ATPase [General function prediction only]; Region: COG4087
565040001957	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
565040001958	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
565040001959	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
565040001960	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040001961	catalytic residue [active]
565040001962	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
565040001963	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
565040001964	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
565040001965	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
565040001966	putative catalytic cysteine [active]
565040001967	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
565040001968	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
565040001969	active site
565040001970	(T/H)XGH motif; other site
565040001971	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
565040001972	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
565040001973	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
565040001974	Uncharacterized conserved protein [Function unknown]; Region: COG1615
565040001975	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
565040001976	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
565040001977	Coenzyme A binding pocket [chemical binding]; other site
565040001978	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
565040001979	putative active site [active]
565040001980	catalytic residue [active]
565040001981	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
565040001982	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
565040001983	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
565040001984	ATP binding site [chemical binding]; other site
565040001985	putative Mg++ binding site [ion binding]; other site
565040001986	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
565040001987	nucleotide binding region [chemical binding]; other site
565040001988	ATP-binding site [chemical binding]; other site
565040001989	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
565040001990	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
565040001991	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
565040001992	active site
565040001993	catalytic tetrad [active]
565040001994	enolase; Provisional; Region: eno; PRK00077
565040001995	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
565040001996	dimer interface [polypeptide binding]; other site
565040001997	metal binding site [ion binding]; metal-binding site
565040001998	substrate binding pocket [chemical binding]; other site
565040001999	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
565040002000	Septum formation initiator; Region: DivIC; pfam04977
565040002001	Protein of unknown function (DUF501); Region: DUF501; pfam04417
565040002002	exopolyphosphatase; Region: exo_poly_only; TIGR03706
565040002003	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
565040002004	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
565040002005	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
565040002006	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
565040002007	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
565040002008	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
565040002009	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
565040002010	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
565040002011	Haemolysin-III related; Region: HlyIII; pfam03006
565040002012	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
565040002013	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
565040002014	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
565040002015	PAS fold; Region: PAS_4; pfam08448
565040002016	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
565040002017	Histidine kinase; Region: HisKA_2; pfam07568
565040002018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
565040002019	ATP binding site [chemical binding]; other site
565040002020	Mg2+ binding site [ion binding]; other site
565040002021	G-X-G motif; other site
565040002022	Transcription factor WhiB; Region: Whib; pfam02467
565040002023	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
565040002024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040002025	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
565040002026	Walker A/P-loop; other site
565040002027	ATP binding site [chemical binding]; other site
565040002028	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
565040002029	Transcription factor WhiB; Region: Whib; pfam02467
565040002030	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
565040002031	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
565040002032	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
565040002033	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
565040002034	Eukaryotic phosphomannomutase; Region: PMM; cl17107
565040002035	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
565040002036	Catalytic site [active]
565040002037	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
565040002038	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
565040002039	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
565040002040	dimerization interface [polypeptide binding]; other site
565040002041	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
565040002042	dimer interface [polypeptide binding]; other site
565040002043	phosphorylation site [posttranslational modification]
565040002044	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
565040002045	ATP binding site [chemical binding]; other site
565040002046	Mg2+ binding site [ion binding]; other site
565040002047	G-X-G motif; other site
565040002048	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
565040002049	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
565040002050	active site
565040002051	phosphorylation site [posttranslational modification]
565040002052	intermolecular recognition site; other site
565040002053	dimerization interface [polypeptide binding]; other site
565040002054	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
565040002055	DNA binding site [nucleotide binding]
565040002056	glycogen branching enzyme; Provisional; Region: PRK05402
565040002057	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
565040002058	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
565040002059	active site
565040002060	catalytic site [active]
565040002061	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
565040002062	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
565040002063	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
565040002064	homotrimer interaction site [polypeptide binding]; other site
565040002065	zinc binding site [ion binding]; other site
565040002066	CDP-binding sites; other site
565040002067	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
565040002068	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
565040002069	ABC-ATPase subunit  interface; other site
565040002070	dimer interface [polypeptide binding]; other site
565040002071	putative PBP binding regions; other site
565040002072	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
565040002073	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
565040002074	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
565040002075	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
565040002076	metal binding site [ion binding]; metal-binding site
565040002077	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
565040002078	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
565040002079	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
565040002080	homodimer interface [polypeptide binding]; other site
565040002081	NADP binding site [chemical binding]; other site
565040002082	substrate binding site [chemical binding]; other site
565040002083	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
565040002084	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
565040002085	RNA binding site [nucleotide binding]; other site
565040002086	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
565040002087	RNA binding site [nucleotide binding]; other site
565040002088	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
565040002089	RNA binding site [nucleotide binding]; other site
565040002090	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
565040002091	RNA binding site [nucleotide binding]; other site
565040002092	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
565040002093	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
565040002094	CoA-binding site [chemical binding]; other site
565040002095	ATP-binding [chemical binding]; other site
565040002096	excinuclease ABC subunit B; Provisional; Region: PRK05298
565040002097	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
565040002098	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
565040002099	nucleotide binding region [chemical binding]; other site
565040002100	ATP-binding site [chemical binding]; other site
565040002101	Ultra-violet resistance protein B; Region: UvrB; pfam12344
565040002102	UvrB/uvrC motif; Region: UVR; pfam02151
565040002103	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
565040002104	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
565040002105	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
565040002106	domain interfaces; other site
565040002107	active site
565040002108	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
565040002109	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
565040002110	dimer interface [polypeptide binding]; other site
565040002111	ADP-ribose binding site [chemical binding]; other site
565040002112	active site
565040002113	nudix motif; other site
565040002114	metal binding site [ion binding]; metal-binding site
565040002115	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
565040002116	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
565040002117	active site
565040002118	phosphorylation site [posttranslational modification]
565040002119	intermolecular recognition site; other site
565040002120	dimerization interface [polypeptide binding]; other site
565040002121	ANTAR domain; Region: ANTAR; pfam03861
565040002122	DNA polymerase I; Provisional; Region: PRK05755
565040002123	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
565040002124	active site
565040002125	metal binding site 1 [ion binding]; metal-binding site
565040002126	putative 5' ssDNA interaction site; other site
565040002127	metal binding site 3; metal-binding site
565040002128	metal binding site 2 [ion binding]; metal-binding site
565040002129	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
565040002130	putative DNA binding site [nucleotide binding]; other site
565040002131	putative metal binding site [ion binding]; other site
565040002132	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
565040002133	active site
565040002134	substrate binding site [chemical binding]; other site
565040002135	catalytic site [active]
565040002136	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
565040002137	active site
565040002138	DNA binding site [nucleotide binding]
565040002139	catalytic site [active]
565040002140	Uncharacterized conserved protein [Function unknown]; Region: COG0327
565040002141	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
565040002142	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
565040002143	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
565040002144	dimer interface [polypeptide binding]; other site
565040002145	ADP-ribose binding site [chemical binding]; other site
565040002146	active site
565040002147	nudix motif; other site
565040002148	metal binding site [ion binding]; metal-binding site
565040002149	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
565040002150	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
565040002151	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
565040002152	active site
565040002153	catalytic site [active]
565040002154	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
565040002155	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
565040002156	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
565040002157	non-specific DNA binding site [nucleotide binding]; other site
565040002158	salt bridge; other site
565040002159	sequence-specific DNA binding site [nucleotide binding]; other site
565040002160	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
565040002161	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
565040002162	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
565040002163	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
565040002164	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
565040002165	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
565040002166	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
565040002167	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
565040002168	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
565040002169	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
565040002170	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
565040002171	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
565040002172	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
565040002173	hinge; other site
565040002174	active site
565040002175	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
565040002176	propionate/acetate kinase; Provisional; Region: PRK12379
565040002177	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
565040002178	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
565040002179	catalytic core [active]
565040002180	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
565040002181	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
565040002182	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
565040002183	Substrate binding site; other site
565040002184	Mg++ binding site; other site
565040002185	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
565040002186	active site
565040002187	substrate binding site [chemical binding]; other site
565040002188	CoA binding site [chemical binding]; other site
565040002189	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
565040002190	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
565040002191	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
565040002192	active site
565040002193	Acyltransferase family; Region: Acyl_transf_3; pfam01757
565040002194	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
565040002195	catalytic triad [active]
565040002196	catalytic triad [active]
565040002197	oxyanion hole [active]
565040002198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
565040002199	hypothetical protein; Provisional; Region: PRK13663
565040002200	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
565040002201	Major Facilitator Superfamily; Region: MFS_1; pfam07690
565040002202	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040002203	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
565040002204	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040002205	Walker A motif; other site
565040002206	ATP binding site [chemical binding]; other site
565040002207	Walker B motif; other site
565040002208	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
565040002209	Integrase core domain; Region: rve; pfam00665
565040002210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040002211	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
565040002212	Walker A motif; other site
565040002213	ATP binding site [chemical binding]; other site
565040002214	Walker B motif; other site
565040002215	arginine finger; other site
565040002216	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
565040002217	Integrase core domain; Region: rve; pfam00665
565040002218	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
565040002219	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
565040002220	Low molecular weight phosphatase family; Region: LMWPc; cl00105
565040002221	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
565040002222	Sodium Bile acid symporter family; Region: SBF; cl17470
565040002223	GMP synthase; Reviewed; Region: guaA; PRK00074
565040002224	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
565040002225	AMP/PPi binding site [chemical binding]; other site
565040002226	candidate oxyanion hole; other site
565040002227	catalytic triad [active]
565040002228	potential glutamine specificity residues [chemical binding]; other site
565040002229	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
565040002230	ATP Binding subdomain [chemical binding]; other site
565040002231	Ligand Binding sites [chemical binding]; other site
565040002232	Dimerization subdomain; other site
565040002233	putative phosphoketolase; Provisional; Region: PRK05261
565040002234	XFP N-terminal domain; Region: XFP_N; pfam09364
565040002235	XFP C-terminal domain; Region: XFP_C; pfam09363
565040002236	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
565040002237	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040002238	active site
565040002239	motif I; other site
565040002240	motif II; other site
565040002241	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
565040002242	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
565040002243	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
565040002244	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
565040002245	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
565040002246	Walker A/P-loop; other site
565040002247	ATP binding site [chemical binding]; other site
565040002248	Q-loop/lid; other site
565040002249	ABC transporter signature motif; other site
565040002250	Walker B; other site
565040002251	D-loop; other site
565040002252	H-loop/switch region; other site
565040002253	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
565040002254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
565040002255	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
565040002256	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
565040002257	metal binding site [ion binding]; metal-binding site
565040002258	NAD synthetase; Provisional; Region: PRK13981
565040002259	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
565040002260	multimer interface [polypeptide binding]; other site
565040002261	active site
565040002262	catalytic triad [active]
565040002263	protein interface 1 [polypeptide binding]; other site
565040002264	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
565040002265	homodimer interface [polypeptide binding]; other site
565040002266	NAD binding pocket [chemical binding]; other site
565040002267	ATP binding pocket [chemical binding]; other site
565040002268	Mg binding site [ion binding]; other site
565040002269	active-site loop [active]
565040002270	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
565040002271	Pyruvate formate lyase 1; Region: PFL1; cd01678
565040002272	coenzyme A binding site [chemical binding]; other site
565040002273	active site
565040002274	catalytic residues [active]
565040002275	glycine loop; other site
565040002276	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
565040002277	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
565040002278	FeS/SAM binding site; other site
565040002279	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
565040002280	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
565040002281	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
565040002282	active site
565040002283	catalytic site [active]
565040002284	substrate binding site [chemical binding]; other site
565040002285	HRDC domain; Region: HRDC; pfam00570
565040002286	trigger factor; Provisional; Region: tig; PRK01490
565040002287	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
565040002288	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
565040002289	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
565040002290	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
565040002291	putative ion selectivity filter; other site
565040002292	putative pore gating glutamate residue; other site
565040002293	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
565040002294	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
565040002295	dimer interface [polypeptide binding]; other site
565040002296	Clp protease; Region: CLP_protease; pfam00574
565040002297	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
565040002298	oligomer interface [polypeptide binding]; other site
565040002299	active site residues [active]
565040002300	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
565040002301	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
565040002302	oligomer interface [polypeptide binding]; other site
565040002303	active site residues [active]
565040002304	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
565040002305	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
565040002306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040002307	Walker A motif; other site
565040002308	ATP binding site [chemical binding]; other site
565040002309	Walker B motif; other site
565040002310	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
565040002311	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
565040002312	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
565040002313	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
565040002314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
565040002315	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
565040002316	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
565040002317	L-aspartate oxidase; Provisional; Region: PRK06175
565040002318	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
565040002319	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
565040002320	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
565040002321	DNA protecting protein DprA; Region: dprA; TIGR00732
565040002322	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
565040002323	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
565040002324	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040002325	Walker A motif; other site
565040002326	ATP binding site [chemical binding]; other site
565040002327	Walker B motif; other site
565040002328	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
565040002329	hypothetical protein; Provisional; Region: PRK14681
565040002330	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
565040002331	dimer interface [polypeptide binding]; other site
565040002332	pyridoxal binding site [chemical binding]; other site
565040002333	ATP binding site [chemical binding]; other site
565040002334	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
565040002335	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
565040002336	homodimer interface [polypeptide binding]; other site
565040002337	substrate-cofactor binding pocket; other site
565040002338	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040002339	catalytic residue [active]
565040002340	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
565040002341	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
565040002342	Walker A/P-loop; other site
565040002343	ATP binding site [chemical binding]; other site
565040002344	Q-loop/lid; other site
565040002345	ABC transporter signature motif; other site
565040002346	Walker B; other site
565040002347	D-loop; other site
565040002348	H-loop/switch region; other site
565040002349	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
565040002350	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
565040002351	FtsX-like permease family; Region: FtsX; pfam02687
565040002352	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
565040002353	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
565040002354	active site
565040002355	phosphorylation site [posttranslational modification]
565040002356	intermolecular recognition site; other site
565040002357	dimerization interface [polypeptide binding]; other site
565040002358	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
565040002359	DNA binding residues [nucleotide binding]
565040002360	dimerization interface [polypeptide binding]; other site
565040002361	Histidine kinase; Region: HisKA_3; pfam07730
565040002362	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
565040002363	ATP binding site [chemical binding]; other site
565040002364	Mg2+ binding site [ion binding]; other site
565040002365	G-X-G motif; other site
565040002366	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
565040002367	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
565040002368	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
565040002369	GTP-binding protein YchF; Reviewed; Region: PRK09601
565040002370	YchF GTPase; Region: YchF; cd01900
565040002371	G1 box; other site
565040002372	GTP/Mg2+ binding site [chemical binding]; other site
565040002373	Switch I region; other site
565040002374	G2 box; other site
565040002375	Switch II region; other site
565040002376	G3 box; other site
565040002377	G4 box; other site
565040002378	G5 box; other site
565040002379	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
565040002380	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040002381	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
565040002382	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040002383	active site
565040002384	DNA binding site [nucleotide binding]
565040002385	Int/Topo IB signature motif; other site
565040002386	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
565040002387	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
565040002388	hypothetical protein; Provisional; Region: PRK06762
565040002389	AAA domain; Region: AAA_33; pfam13671
565040002390	RNA ligase; Region: RNA_lig_T4_1; pfam09511
565040002391	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
565040002392	active site
565040002393	metal binding site [ion binding]; metal-binding site
565040002394	hypothetical protein; Provisional; Region: PRK11770
565040002395	Domain of unknown function (DUF307); Region: DUF307; pfam03733
565040002396	Domain of unknown function (DUF307); Region: DUF307; pfam03733
565040002397	putative transporter; Provisional; Region: PRK10504
565040002398	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040002399	putative substrate translocation pore; other site
565040002400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040002401	FOG: CBS domain [General function prediction only]; Region: COG0517
565040002402	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636
565040002403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040002404	H+ Antiporter protein; Region: 2A0121; TIGR00900
565040002405	putative substrate translocation pore; other site
565040002406	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
565040002407	Catalytic domain of Protein Kinases; Region: PKc; cd00180
565040002408	active site
565040002409	ATP binding site [chemical binding]; other site
565040002410	substrate binding site [chemical binding]; other site
565040002411	activation loop (A-loop); other site
565040002412	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
565040002413	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
565040002414	Short C-terminal domain; Region: SHOCT; pfam09851
565040002415	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
565040002416	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
565040002417	non-specific DNA binding site [nucleotide binding]; other site
565040002418	salt bridge; other site
565040002419	sequence-specific DNA binding site [nucleotide binding]; other site
565040002420	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
565040002421	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
565040002422	catalytic core [active]
565040002423	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
565040002424	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
565040002425	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
565040002426	ATP binding site [chemical binding]; other site
565040002427	putative Mg++ binding site [ion binding]; other site
565040002428	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
565040002429	nucleotide binding region [chemical binding]; other site
565040002430	ATP-binding site [chemical binding]; other site
565040002431	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
565040002432	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
565040002433	WHG domain; Region: WHG; pfam13305
565040002434	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
565040002435	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
565040002436	active site
565040002437	catalytic site [active]
565040002438	carbon starvation protein A; Provisional; Region: PRK15015
565040002439	Carbon starvation protein CstA; Region: CstA; pfam02554
565040002440	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
565040002441	Protein of unknown function (DUF466); Region: DUF466; cl01082
565040002442	Phosphate transporter family; Region: PHO4; pfam01384
565040002443	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
565040002444	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
565040002445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
565040002446	active site
565040002447	phosphorylation site [posttranslational modification]
565040002448	intermolecular recognition site; other site
565040002449	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
565040002450	DNA binding residues [nucleotide binding]
565040002451	dimerization interface [polypeptide binding]; other site
565040002452	Histidine kinase; Region: HisKA_3; pfam07730
565040002453	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
565040002454	ATP binding site [chemical binding]; other site
565040002455	Mg2+ binding site [ion binding]; other site
565040002456	G-X-G motif; other site
565040002457	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
565040002458	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
565040002459	Walker A/P-loop; other site
565040002460	ATP binding site [chemical binding]; other site
565040002461	Q-loop/lid; other site
565040002462	ABC transporter signature motif; other site
565040002463	Walker B; other site
565040002464	D-loop; other site
565040002465	H-loop/switch region; other site
565040002466	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
565040002467	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
565040002468	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
565040002469	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
565040002470	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
565040002471	Divergent AAA domain; Region: AAA_4; pfam04326
565040002472	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
565040002473	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
565040002474	Isochorismatase family; Region: Isochorismatase; pfam00857
565040002475	catalytic triad [active]
565040002476	metal binding site [ion binding]; metal-binding site
565040002477	conserved cis-peptide bond; other site
565040002478	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
565040002479	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
565040002480	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
565040002481	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
565040002482	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
565040002483	salt bridge; other site
565040002484	non-specific DNA binding site [nucleotide binding]; other site
565040002485	sequence-specific DNA binding site [nucleotide binding]; other site
565040002486	xanthine permease; Region: pbuX; TIGR03173
565040002487	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
565040002488	active site
565040002489	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
565040002490	Part of AAA domain; Region: AAA_19; pfam13245
565040002491	Family description; Region: UvrD_C_2; pfam13538
565040002492	Domain of unknown function (DUF4418); Region: DUF4418; pfam14387
565040002493	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
565040002494	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
565040002495	FtsX-like permease family; Region: FtsX; pfam02687
565040002496	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
565040002497	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
565040002498	Walker A/P-loop; other site
565040002499	ATP binding site [chemical binding]; other site
565040002500	Q-loop/lid; other site
565040002501	ABC transporter signature motif; other site
565040002502	Walker B; other site
565040002503	D-loop; other site
565040002504	H-loop/switch region; other site
565040002505	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
565040002506	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
565040002507	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
565040002508	RNA binding surface [nucleotide binding]; other site
565040002509	Acyltransferase family; Region: Acyl_transf_3; pfam01757
565040002510	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
565040002511	catalytic triad [active]
565040002512	catalytic triad [active]
565040002513	oxyanion hole [active]
565040002514	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
565040002515	catalytic core [active]
565040002516	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
565040002517	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
565040002518	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
565040002519	motif 1; other site
565040002520	active site
565040002521	motif 2; other site
565040002522	motif 3; other site
565040002523	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
565040002524	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
565040002525	YceG-like family; Region: YceG; pfam02618
565040002526	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
565040002527	dimerization interface [polypeptide binding]; other site
565040002528	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
565040002529	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
565040002530	Tetramer interface [polypeptide binding]; other site
565040002531	active site
565040002532	FMN-binding site [chemical binding]; other site
565040002533	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
565040002534	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
565040002535	ADP binding site [chemical binding]; other site
565040002536	magnesium binding site [ion binding]; other site
565040002537	putative shikimate binding site; other site
565040002538	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
565040002539	active site
565040002540	dimer interface [polypeptide binding]; other site
565040002541	metal binding site [ion binding]; metal-binding site
565040002542	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
565040002543	Dehydroquinase class II; Region: DHquinase_II; pfam01220
565040002544	trimer interface [polypeptide binding]; other site
565040002545	active site
565040002546	dimer interface [polypeptide binding]; other site
565040002547	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
565040002548	dipeptidase, putative; Region: dipeptidaselike; TIGR01887
565040002549	metal binding site [ion binding]; metal-binding site
565040002550	CTP synthetase; Validated; Region: pyrG; PRK05380
565040002551	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
565040002552	Catalytic site [active]
565040002553	active site
565040002554	UTP binding site [chemical binding]; other site
565040002555	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
565040002556	active site
565040002557	putative oxyanion hole; other site
565040002558	catalytic triad [active]
565040002559	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
565040002560	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
565040002561	FeS assembly protein SufB; Region: sufB; TIGR01980
565040002562	FeS assembly protein SufD; Region: sufD; TIGR01981
565040002563	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
565040002564	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
565040002565	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
565040002566	Walker A/P-loop; other site
565040002567	ATP binding site [chemical binding]; other site
565040002568	Q-loop/lid; other site
565040002569	ABC transporter signature motif; other site
565040002570	Walker B; other site
565040002571	D-loop; other site
565040002572	H-loop/switch region; other site
565040002573	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
565040002574	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
565040002575	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
565040002576	catalytic residue [active]
565040002577	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
565040002578	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
565040002579	trimerization site [polypeptide binding]; other site
565040002580	active site
565040002581	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
565040002582	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
565040002583	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
565040002584	ligand binding site; other site
565040002585	oligomer interface; other site
565040002586	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
565040002587	dimer interface [polypeptide binding]; other site
565040002588	N-terminal domain interface [polypeptide binding]; other site
565040002589	sulfate 1 binding site; other site
565040002590	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
565040002591	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
565040002592	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
565040002593	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
565040002594	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
565040002595	nucleotide binding site/active site [active]
565040002596	HIT family signature motif; other site
565040002597	catalytic residue [active]
565040002598	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
565040002599	PhoH-like protein; Region: PhoH; pfam02562
565040002600	metal-binding heat shock protein; Provisional; Region: PRK00016
565040002601	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
565040002602	Domain of unknown function DUF21; Region: DUF21; pfam01595
565040002603	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
565040002604	Transporter associated domain; Region: CorC_HlyC; smart01091
565040002605	GTPase Era; Reviewed; Region: era; PRK00089
565040002606	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
565040002607	G1 box; other site
565040002608	GTP/Mg2+ binding site [chemical binding]; other site
565040002609	Switch I region; other site
565040002610	G2 box; other site
565040002611	Switch II region; other site
565040002612	G3 box; other site
565040002613	G4 box; other site
565040002614	G5 box; other site
565040002615	KH domain; Region: KH_2; pfam07650
565040002616	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
565040002617	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
565040002618	acyl-activating enzyme (AAE) consensus motif; other site
565040002619	putative AMP binding site [chemical binding]; other site
565040002620	putative active site [active]
565040002621	putative CoA binding site [chemical binding]; other site
565040002622	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
565040002623	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
565040002624	ligand binding site [chemical binding]; other site
565040002625	homodimer interface [polypeptide binding]; other site
565040002626	NAD(P) binding site [chemical binding]; other site
565040002627	trimer interface B [polypeptide binding]; other site
565040002628	trimer interface A [polypeptide binding]; other site
565040002629	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
565040002630	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
565040002631	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
565040002632	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
565040002633	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
565040002634	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
565040002635	5S rRNA interface [nucleotide binding]; other site
565040002636	CTC domain interface [polypeptide binding]; other site
565040002637	L16 interface [polypeptide binding]; other site
565040002638	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
565040002639	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
565040002640	homodimer interface [polypeptide binding]; other site
565040002641	substrate-cofactor binding pocket; other site
565040002642	catalytic residue [active]
565040002643	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
565040002644	amidase catalytic site [active]
565040002645	substrate binding site [chemical binding]; other site
565040002646	Zn binding residues [ion binding]; other site
565040002647	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
565040002648	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
565040002649	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
565040002650	putative active site [active]
565040002651	putative NTP binding site [chemical binding]; other site
565040002652	putative nucleic acid binding site [nucleotide binding]; other site
565040002653	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
565040002654	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
565040002655	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
565040002656	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
565040002657	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
565040002658	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
565040002659	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
565040002660	active site
565040002661	cytidine deaminase, homodimeric; Region: cyt_deam_dimer; TIGR01355
565040002662	RelB antitoxin; Region: RelB; cl01171
565040002663	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
565040002664	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
565040002665	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
565040002666	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
565040002667	Probable transposase; Region: OrfB_IS605; pfam01385
565040002668	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
565040002669	Prophage antirepressor [Transcription]; Region: COG3617
565040002670	BRO family, N-terminal domain; Region: Bro-N; smart01040
565040002671	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
565040002672	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
565040002673	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
565040002674	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
565040002675	BRO family, N-terminal domain; Region: Bro-N; pfam02498
565040002676	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
565040002677	Transcription factor WhiB; Region: Whib; pfam02467
565040002678	ParB-like nuclease domain; Region: ParBc; pfam02195
565040002679	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
565040002680	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
565040002681	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
565040002682	RecT family; Region: RecT; cl04285
565040002683	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040002684	active site
565040002685	Int/Topo IB signature motif; other site
565040002686	DNA binding site [nucleotide binding]
565040002687	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
565040002688	homodimer interface [polypeptide binding]; other site
565040002689	MazG family protein; Region: mazG; TIGR00444
565040002690	metal binding site [ion binding]; metal-binding site
565040002691	UPF0126 domain; Region: UPF0126; pfam03458
565040002692	Predicted membrane protein [Function unknown]; Region: COG2860
565040002693	UPF0126 domain; Region: UPF0126; pfam03458
565040002694	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
565040002695	GTP-binding protein LepA; Provisional; Region: PRK05433
565040002696	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
565040002697	G1 box; other site
565040002698	putative GEF interaction site [polypeptide binding]; other site
565040002699	GTP/Mg2+ binding site [chemical binding]; other site
565040002700	Switch I region; other site
565040002701	G2 box; other site
565040002702	G3 box; other site
565040002703	Switch II region; other site
565040002704	G4 box; other site
565040002705	G5 box; other site
565040002706	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
565040002707	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
565040002708	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
565040002709	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
565040002710	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
565040002711	FeS/SAM binding site; other site
565040002712	HemN C-terminal domain; Region: HemN_C; pfam06969
565040002713	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040002714	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040002715	DNA binding site [nucleotide binding]
565040002716	domain linker motif; other site
565040002717	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040002718	dimerization interface [polypeptide binding]; other site
565040002719	ligand binding site [chemical binding]; other site
565040002720	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
565040002721	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040002722	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040002723	Integrase core domain; Region: rve; pfam00665
565040002724	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
565040002725	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
565040002726	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
565040002727	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
565040002728	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040002729	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040002730	DNA binding site [nucleotide binding]
565040002731	domain linker motif; other site
565040002732	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
565040002733	ligand binding site [chemical binding]; other site
565040002734	dimerization interface (open form) [polypeptide binding]; other site
565040002735	dimerization interface (closed form) [polypeptide binding]; other site
565040002736	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
565040002737	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
565040002738	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040002739	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040002740	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
565040002741	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
565040002742	active site
565040002743	dimer interface [polypeptide binding]; other site
565040002744	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
565040002745	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
565040002746	active site
565040002747	FMN binding site [chemical binding]; other site
565040002748	substrate binding site [chemical binding]; other site
565040002749	3Fe-4S cluster binding site [ion binding]; other site
565040002750	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
565040002751	domain interface; other site
565040002752	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
565040002753	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
565040002754	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
565040002755	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
565040002756	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
565040002757	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
565040002758	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
565040002759	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
565040002760	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
565040002761	Walker A/P-loop; other site
565040002762	ATP binding site [chemical binding]; other site
565040002763	Q-loop/lid; other site
565040002764	ABC transporter signature motif; other site
565040002765	Walker B; other site
565040002766	D-loop; other site
565040002767	H-loop/switch region; other site
565040002768	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040002769	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
565040002770	active site
565040002771	motif I; other site
565040002772	motif II; other site
565040002773	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040002774	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
565040002775	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
565040002776	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
565040002777	catalytic triad [active]
565040002778	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
565040002779	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
565040002780	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
565040002781	homodimer interface [polypeptide binding]; other site
565040002782	chemical substrate binding site [chemical binding]; other site
565040002783	oligomer interface [polypeptide binding]; other site
565040002784	metal binding site [ion binding]; metal-binding site
565040002785	GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439
565040002786	GIY-YIG motif/motif A; other site
565040002787	putative active site [active]
565040002788	putative metal binding site [ion binding]; other site
565040002789	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
565040002790	Uncharacterized conserved protein [Function unknown]; Region: COG3410
565040002791	Predicted permeases [General function prediction only]; Region: RarD; COG2962
565040002792	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
565040002793	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
565040002794	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
565040002795	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
565040002796	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
565040002797	active site
565040002798	catalytic tetrad [active]
565040002799	Predicted esterase [General function prediction only]; Region: COG0400
565040002800	putative hydrolase; Provisional; Region: PRK11460
565040002801	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
565040002802	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
565040002803	S-adenosylmethionine binding site [chemical binding]; other site
565040002804	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
565040002805	catalytic core [active]
565040002806	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
565040002807	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
565040002808	THF binding site; other site
565040002809	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
565040002810	substrate binding site [chemical binding]; other site
565040002811	THF binding site; other site
565040002812	zinc-binding site [ion binding]; other site
565040002813	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
565040002814	FAD binding site [chemical binding]; other site
565040002815	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
565040002816	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
565040002817	active site
565040002818	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
565040002819	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
565040002820	metal binding triad; other site
565040002821	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
565040002822	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
565040002823	metal binding triad; other site
565040002824	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
565040002825	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
565040002826	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
565040002827	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
565040002828	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
565040002829	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
565040002830	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
565040002831	dihydroorotase; Validated; Region: pyrC; PRK09357
565040002832	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
565040002833	active site
565040002834	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
565040002835	active site
565040002836	dimer interface [polypeptide binding]; other site
565040002837	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
565040002838	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
565040002839	FAD binding pocket [chemical binding]; other site
565040002840	FAD binding motif [chemical binding]; other site
565040002841	phosphate binding motif [ion binding]; other site
565040002842	beta-alpha-beta structure motif; other site
565040002843	NAD binding pocket [chemical binding]; other site
565040002844	Iron coordination center [ion binding]; other site
565040002845	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
565040002846	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
565040002847	heterodimer interface [polypeptide binding]; other site
565040002848	active site
565040002849	FMN binding site [chemical binding]; other site
565040002850	homodimer interface [polypeptide binding]; other site
565040002851	substrate binding site [chemical binding]; other site
565040002852	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
565040002853	active site
565040002854	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
565040002855	Transcriptional regulator [Transcription]; Region: LysR; COG0583
565040002856	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
565040002857	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
565040002858	dimerization interface [polypeptide binding]; other site
565040002859	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
565040002860	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040002861	motif II; other site
565040002862	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
565040002863	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
565040002864	aspartate aminotransferase; Provisional; Region: PRK06836
565040002865	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
565040002866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040002867	homodimer interface [polypeptide binding]; other site
565040002868	catalytic residue [active]
565040002869	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
565040002870	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
565040002871	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
565040002872	Catalytic site [active]
565040002873	S-methylmethionine transporter; Provisional; Region: PRK11387
565040002874	Spore germination protein; Region: Spore_permease; cl17796
565040002875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040002876	Major Facilitator Superfamily; Region: MFS_1; pfam07690
565040002877	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
565040002878	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
565040002879	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
565040002880	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
565040002881	nudix motif; other site
565040002882	Predicted amidohydrolase [General function prediction only]; Region: COG0388
565040002883	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
565040002884	Fic/DOC family; Region: Fic; cl00960
565040002885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
565040002886	RelB antitoxin; Region: RelB; cl01171
565040002887	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
565040002888	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
565040002889	FtsX-like permease family; Region: FtsX; pfam02687
565040002890	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
565040002891	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
565040002892	Walker A/P-loop; other site
565040002893	ATP binding site [chemical binding]; other site
565040002894	Q-loop/lid; other site
565040002895	ABC transporter signature motif; other site
565040002896	Walker B; other site
565040002897	D-loop; other site
565040002898	H-loop/switch region; other site
565040002899	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
565040002900	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
565040002901	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
565040002902	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
565040002903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
565040002904	active site
565040002905	phosphorylation site [posttranslational modification]
565040002906	intermolecular recognition site; other site
565040002907	dimerization interface [polypeptide binding]; other site
565040002908	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
565040002909	DNA binding residues [nucleotide binding]
565040002910	dimerization interface [polypeptide binding]; other site
565040002911	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
565040002912	Histidine kinase; Region: HisKA_3; pfam07730
565040002913	Transposase, Mutator family; Region: Transposase_mut; pfam00872
565040002914	MULE transposase domain; Region: MULE; pfam10551
565040002915	Abi-like protein; Region: Abi_2; pfam07751
565040002916	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
565040002917	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
565040002918	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805
565040002919	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
565040002920	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
565040002921	Coenzyme A binding pocket [chemical binding]; other site
565040002922	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
565040002923	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
565040002924	VanZ like family; Region: VanZ; pfam04892
565040002925	Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833
565040002926	S-methylmethionine transporter; Provisional; Region: PRK11387
565040002927	endonuclease IV; Provisional; Region: PRK01060
565040002928	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
565040002929	AP (apurinic/apyrimidinic) site pocket; other site
565040002930	DNA interaction; other site
565040002931	Metal-binding active site; metal-binding site
565040002932	bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802
565040002933	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
565040002934	active site
565040002935	ribulose/triose binding site [chemical binding]; other site
565040002936	phosphate binding site [ion binding]; other site
565040002937	substrate (anthranilate) binding pocket [chemical binding]; other site
565040002938	product (indole) binding pocket [chemical binding]; other site
565040002939	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
565040002940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040002941	catalytic residue [active]
565040002942	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
565040002943	substrate binding site [chemical binding]; other site
565040002944	active site
565040002945	catalytic residues [active]
565040002946	heterodimer interface [polypeptide binding]; other site
565040002947	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
565040002948	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
565040002949	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
565040002950	substrate binding site [chemical binding]; other site
565040002951	hexamer interface [polypeptide binding]; other site
565040002952	metal binding site [ion binding]; metal-binding site
565040002953	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
565040002954	homodimer interface [polypeptide binding]; other site
565040002955	putative metal binding site [ion binding]; other site
565040002956	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
565040002957	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
565040002958	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
565040002959	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
565040002960	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
565040002961	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
565040002962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
565040002963	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
565040002964	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
565040002965	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
565040002966	phosphopeptide binding site; other site
565040002967	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
565040002968	DNA binding residues [nucleotide binding]
565040002969	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
565040002970	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
565040002971	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040002972	motif II; other site
565040002973	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
565040002974	DEAD-like helicases superfamily; Region: DEXDc; smart00487
565040002975	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
565040002976	ATP binding site [chemical binding]; other site
565040002977	putative Mg++ binding site [ion binding]; other site
565040002978	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
565040002979	nucleotide binding region [chemical binding]; other site
565040002980	ATP-binding site [chemical binding]; other site
565040002981	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
565040002982	Predicted transcriptional regulator [Transcription]; Region: COG2378
565040002983	WYL domain; Region: WYL; pfam13280
565040002984	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
565040002985	active site
565040002986	bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518
565040002987	AAA domain; Region: AAA_17; pfam13207
565040002988	Cytidylate kinase; Region: Cytidylate_kin; pfam02224
565040002989	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
565040002990	G1 box; other site
565040002991	GTP/Mg2+ binding site [chemical binding]; other site
565040002992	Switch I region; other site
565040002993	G2 box; other site
565040002994	Switch II region; other site
565040002995	G3 box; other site
565040002996	G4 box; other site
565040002997	G5 box; other site
565040002998	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
565040002999	G1 box; other site
565040003000	GTP/Mg2+ binding site [chemical binding]; other site
565040003001	Switch I region; other site
565040003002	G2 box; other site
565040003003	G3 box; other site
565040003004	Switch II region; other site
565040003005	G4 box; other site
565040003006	G5 box; other site
565040003007	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
565040003008	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
565040003009	RNA binding surface [nucleotide binding]; other site
565040003010	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
565040003011	active site
565040003012	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
565040003013	amphipathic channel; other site
565040003014	Asn-Pro-Ala signature motifs; other site
565040003015	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
565040003016	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
565040003017	purine monophosphate binding site [chemical binding]; other site
565040003018	dimer interface [polypeptide binding]; other site
565040003019	putative catalytic residues [active]
565040003020	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
565040003021	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
565040003022	CoA binding domain; Region: CoA_binding; smart00881
565040003023	CoA-ligase; Region: Ligase_CoA; pfam00549
565040003024	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
565040003025	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
565040003026	CoA-ligase; Region: Ligase_CoA; pfam00549
565040003027	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
565040003028	active site
565040003029	Preprotein translocase subunit; Region: YajC; pfam02699
565040003030	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
565040003031	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040003032	Walker A motif; other site
565040003033	ATP binding site [chemical binding]; other site
565040003034	Walker B motif; other site
565040003035	arginine finger; other site
565040003036	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
565040003037	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
565040003038	RuvA N terminal domain; Region: RuvA_N; pfam01330
565040003039	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
565040003040	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
565040003041	active site
565040003042	putative DNA-binding cleft [nucleotide binding]; other site
565040003043	dimer interface [polypeptide binding]; other site
565040003044	hypothetical protein; Validated; Region: PRK00110
565040003045	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
565040003046	nucleotide binding site/active site [active]
565040003047	HIT family signature motif; other site
565040003048	catalytic residue [active]
565040003049	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
565040003050	thiS-thiF/thiG interaction site; other site
565040003051	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
565040003052	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
565040003053	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
565040003054	active site
565040003055	dimer interface [polypeptide binding]; other site
565040003056	motif 1; other site
565040003057	motif 2; other site
565040003058	motif 3; other site
565040003059	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
565040003060	anticodon binding site; other site
565040003061	PAC2 family; Region: PAC2; pfam09754
565040003062	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
565040003063	Fructosamine kinase; Region: Fructosamin_kin; cl17579
565040003064	Phosphotransferase enzyme family; Region: APH; pfam01636
565040003065	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040003066	active site
565040003067	DNA binding site [nucleotide binding]
565040003068	Int/Topo IB signature motif; other site
565040003069	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
565040003070	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
565040003071	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
565040003072	Excalibur calcium-binding domain; Region: Excalibur; smart00894
565040003073	Domain of unknown function (DUF955); Region: DUF955; pfam06114
565040003074	BRO family, N-terminal domain; Region: Bro-N; smart01040
565040003075	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
565040003076	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
565040003077	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
565040003078	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
565040003079	nucleotide binding site [chemical binding]; other site
565040003080	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040003081	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040003082	Integrase core domain; Region: rve; pfam00665
565040003083	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
565040003084	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
565040003085	potential frameshift: common BLAST hit: gi|291301685|ref|YP_003512963.1| Terminase
565040003086	Phage Terminase; Region: Terminase_1; pfam03354
565040003087	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
565040003088	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
565040003089	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040003090	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040003091	Integrase core domain; Region: rve; pfam00665
565040003092	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
565040003093	Poxvirus P4B major core protein; Region: Pox_P4B; pfam03292
565040003094	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040003095	active site
565040003096	DNA binding site [nucleotide binding]
565040003097	Int/Topo IB signature motif; other site
565040003098	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
565040003099	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
565040003100	active site
565040003101	chaperone protein DnaJ; Provisional; Region: PRK14278
565040003102	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
565040003103	HSP70 interaction site [polypeptide binding]; other site
565040003104	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
565040003105	Zn binding sites [ion binding]; other site
565040003106	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
565040003107	dimer interface [polypeptide binding]; other site
565040003108	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
565040003109	Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969
565040003110	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
565040003111	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
565040003112	TPP-binding site [chemical binding]; other site
565040003113	dimer interface [polypeptide binding]; other site
565040003114	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
565040003115	PYR/PP interface [polypeptide binding]; other site
565040003116	dimer interface [polypeptide binding]; other site
565040003117	TPP binding site [chemical binding]; other site
565040003118	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
565040003119	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
565040003120	putative active site [active]
565040003121	transaldolase; Provisional; Region: PRK03903
565040003122	catalytic residue [active]
565040003123	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
565040003124	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
565040003125	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
565040003126	non-specific DNA binding site [nucleotide binding]; other site
565040003127	salt bridge; other site
565040003128	sequence-specific DNA binding site [nucleotide binding]; other site
565040003129	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
565040003130	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040003131	homodimer interface [polypeptide binding]; other site
565040003132	catalytic residue [active]
565040003133	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
565040003134	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040003135	active site
565040003136	motif I; other site
565040003137	motif II; other site
565040003138	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
565040003139	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
565040003140	tetramer (dimer of dimers) interface [polypeptide binding]; other site
565040003141	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
565040003142	NAD binding site [chemical binding]; other site
565040003143	dimer interface [polypeptide binding]; other site
565040003144	substrate binding site [chemical binding]; other site
565040003145	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
565040003146	triosephosphate isomerase; Provisional; Region: PRK14567
565040003147	substrate binding site [chemical binding]; other site
565040003148	dimer interface [polypeptide binding]; other site
565040003149	catalytic triad [active]
565040003150	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
565040003151	Phosphoglycerate kinase; Region: PGK; pfam00162
565040003152	substrate binding site [chemical binding]; other site
565040003153	hinge regions; other site
565040003154	ADP binding site [chemical binding]; other site
565040003155	catalytic site [active]
565040003156	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
565040003157	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
565040003158	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
565040003159	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
565040003160	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
565040003161	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
565040003162	shikimate binding site; other site
565040003163	NAD(P) binding site [chemical binding]; other site
565040003164	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
565040003165	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
565040003166	GIY-YIG motif/motif A; other site
565040003167	active site
565040003168	catalytic site [active]
565040003169	putative DNA binding site [nucleotide binding]; other site
565040003170	metal binding site [ion binding]; metal-binding site
565040003171	UvrB/uvrC motif; Region: UVR; pfam02151
565040003172	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
565040003173	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
565040003174	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
565040003175	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
565040003176	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
565040003177	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
565040003178	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
565040003179	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
565040003180	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
565040003181	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
565040003182	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
565040003183	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
565040003184	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
565040003185	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
565040003186	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
565040003187	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
565040003188	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
565040003189	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
565040003190	Walker A/P-loop; other site
565040003191	ATP binding site [chemical binding]; other site
565040003192	Q-loop/lid; other site
565040003193	ABC transporter signature motif; other site
565040003194	Walker B; other site
565040003195	D-loop; other site
565040003196	H-loop/switch region; other site
565040003197	Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226
565040003198	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
565040003199	Walker A/P-loop; other site
565040003200	ATP binding site [chemical binding]; other site
565040003201	Q-loop/lid; other site
565040003202	ABC transporter signature motif; other site
565040003203	Walker B; other site
565040003204	D-loop; other site
565040003205	H-loop/switch region; other site
565040003206	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
565040003207	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
565040003208	classical (c) SDRs; Region: SDR_c; cd05233
565040003209	NAD(P) binding site [chemical binding]; other site
565040003210	active site
565040003211	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
565040003212	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040003213	Walker A/P-loop; other site
565040003214	ATP binding site [chemical binding]; other site
565040003215	Q-loop/lid; other site
565040003216	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
565040003217	ABC transporter signature motif; other site
565040003218	Walker B; other site
565040003219	D-loop; other site
565040003220	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
565040003221	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
565040003222	anthranilate synthase component I; Provisional; Region: PRK13571
565040003223	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
565040003224	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
565040003225	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
565040003226	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
565040003227	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
565040003228	substrate binding site [chemical binding]; other site
565040003229	glutamase interaction surface [polypeptide binding]; other site
565040003230	intracellular protease, PfpI family; Region: PfpI; TIGR01382
565040003231	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
565040003232	proposed catalytic triad [active]
565040003233	conserved cys residue [active]
565040003234	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
565040003235	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
565040003236	FeS/SAM binding site; other site
565040003237	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
565040003238	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
565040003239	ribosome recycling factor; Reviewed; Region: frr; PRK00083
565040003240	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
565040003241	hinge region; other site
565040003242	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
565040003243	putative nucleotide binding site [chemical binding]; other site
565040003244	uridine monophosphate binding site [chemical binding]; other site
565040003245	homohexameric interface [polypeptide binding]; other site
565040003246	elongation factor Ts; Provisional; Region: tsf; PRK09377
565040003247	Elongation factor TS; Region: EF_TS; pfam00889
565040003248	Elongation factor TS; Region: EF_TS; pfam00889
565040003249	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
565040003250	rRNA interaction site [nucleotide binding]; other site
565040003251	S8 interaction site; other site
565040003252	putative laminin-1 binding site; other site
565040003253	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
565040003254	active site
565040003255	catalytic residues [active]
565040003256	metal binding site [ion binding]; metal-binding site
565040003257	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
565040003258	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
565040003259	acyl-activating enzyme (AAE) consensus motif; other site
565040003260	putative AMP binding site [chemical binding]; other site
565040003261	putative active site [active]
565040003262	putative CoA binding site [chemical binding]; other site
565040003263	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
565040003264	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
565040003265	active site
565040003266	isocitrate dehydrogenase; Validated; Region: PRK08299
565040003267	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
565040003268	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
565040003269	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
565040003270	Peptidase family M23; Region: Peptidase_M23; pfam01551
565040003271	UGMP family protein; Validated; Region: PRK09604
565040003272	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
565040003273	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
565040003274	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
565040003275	Coenzyme A binding pocket [chemical binding]; other site
565040003276	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
565040003277	Glycoprotease family; Region: Peptidase_M22; pfam00814
565040003278	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
565040003279	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
565040003280	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
565040003281	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
565040003282	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
565040003283	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
565040003284	active site
565040003285	Competence protein; Region: Competence; pfam03772
565040003286	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
565040003287	Helix-hairpin-helix motif; Region: HHH; pfam00633
565040003288	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
565040003289	Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495
565040003290	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
565040003291	active site
565040003292	HIGH motif; other site
565040003293	nucleotide binding site [chemical binding]; other site
565040003294	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
565040003295	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
565040003296	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
565040003297	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
565040003298	active site
565040003299	KMSKS motif; other site
565040003300	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
565040003301	tRNA binding surface [nucleotide binding]; other site
565040003302	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
565040003303	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
565040003304	substrate binding pocket [chemical binding]; other site
565040003305	membrane-bound complex binding site; other site
565040003306	hinge residues; other site
565040003307	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
565040003308	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
565040003309	Cl binding site [ion binding]; other site
565040003310	oligomer interface [polypeptide binding]; other site
565040003311	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
565040003312	catalytic core [active]
565040003313	Methyltransferase domain; Region: Methyltransf_26; pfam13659
565040003314	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
565040003315	EamA-like transporter family; Region: EamA; pfam00892
565040003316	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
565040003317	EamA-like transporter family; Region: EamA; pfam00892
565040003318	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
565040003319	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040003320	DNA binding site [nucleotide binding]
565040003321	Int/Topo IB signature motif; other site
565040003322	active site
565040003323	EcsC protein family; Region: EcsC; pfam12787
565040003324	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
565040003325	Restriction endonuclease XhoI; Region: XhoI; pfam04555
565040003326	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
565040003327	non-specific DNA binding site [nucleotide binding]; other site
565040003328	salt bridge; other site
565040003329	sequence-specific DNA binding site [nucleotide binding]; other site
565040003330	DNA topoisomerase III; Provisional; Region: PRK07726
565040003331	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
565040003332	active site
565040003333	putative interdomain interaction site [polypeptide binding]; other site
565040003334	putative metal-binding site [ion binding]; other site
565040003335	putative nucleotide binding site [chemical binding]; other site
565040003336	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
565040003337	domain I; other site
565040003338	DNA binding groove [nucleotide binding]
565040003339	phosphate binding site [ion binding]; other site
565040003340	domain II; other site
565040003341	domain III; other site
565040003342	nucleotide binding site [chemical binding]; other site
565040003343	catalytic site [active]
565040003344	domain IV; other site
565040003345	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
565040003346	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
565040003347	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
565040003348	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
565040003349	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
565040003350	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
565040003351	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
565040003352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
565040003353	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
565040003354	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
565040003355	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
565040003356	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
565040003357	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
565040003358	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
565040003359	nucleotide binding region [chemical binding]; other site
565040003360	ATP-binding site [chemical binding]; other site
565040003361	AAA-like domain; Region: AAA_10; pfam12846
565040003362	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
565040003363	Walker A motif; other site
565040003364	ATP binding site [chemical binding]; other site
565040003365	Walker B motif; other site
565040003366	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
565040003367	non-specific DNA binding site [nucleotide binding]; other site
565040003368	salt bridge; other site
565040003369	sequence-specific DNA binding site [nucleotide binding]; other site
565040003370	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040003371	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040003372	Integrase core domain; Region: rve; pfam00665
565040003373	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
565040003374	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
565040003375	non-specific DNA binding site [nucleotide binding]; other site
565040003376	salt bridge; other site
565040003377	sequence-specific DNA binding site [nucleotide binding]; other site
565040003378	Domain of unknown function (DUF955); Region: DUF955; cl01076
565040003379	Dot/Icm substrate protein; Region: SidE; pfam12252
565040003380	CHAP domain; Region: CHAP; cl17642
565040003381	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
565040003382	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040003383	Walker A motif; other site
565040003384	ATP binding site [chemical binding]; other site
565040003385	Walker B motif; other site
565040003386	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
565040003387	Integrase core domain; Region: rve; pfam00665
565040003388	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
565040003389	N-acetyl-D-glucosamine binding site [chemical binding]; other site
565040003390	catalytic residue [active]
565040003391	AAA-like domain; Region: AAA_10; pfam12846
565040003392	Domain of unknown function DUF87; Region: DUF87; pfam01935
565040003393	PrgI family protein; Region: PrgI; pfam12666
565040003394	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
565040003395	metal ion-dependent adhesion site (MIDAS); other site
565040003396	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
565040003397	Cna protein B-type domain; Region: Cna_B; pfam05738
565040003398	Protein of unknown function (DUF1109); Region: DUF1109; cl02071
565040003399	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040003400	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040003401	Integrase core domain; Region: rve; pfam00665
565040003402	Restriction endonuclease; Region: Mrr_cat; pfam04471
565040003403	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
565040003404	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
565040003405	P-loop; other site
565040003406	Magnesium ion binding site [ion binding]; other site
565040003407	Helix-turn-helix domain; Region: HTH_36; pfam13730
565040003408	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
565040003409	active site
565040003410	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
565040003411	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
565040003412	Zn2+ binding site [ion binding]; other site
565040003413	Mg2+ binding site [ion binding]; other site
565040003414	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
565040003415	synthetase active site [active]
565040003416	NTP binding site [chemical binding]; other site
565040003417	metal binding site [ion binding]; metal-binding site
565040003418	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
565040003419	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
565040003420	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
565040003421	trimer interface [polypeptide binding]; other site
565040003422	active site
565040003423	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
565040003424	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
565040003425	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
565040003426	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
565040003427	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
565040003428	CAP-like domain; other site
565040003429	active site
565040003430	primary dimer interface [polypeptide binding]; other site
565040003431	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
565040003432	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
565040003433	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
565040003434	phosphorylation site [posttranslational modification]
565040003435	intermolecular recognition site; other site
565040003436	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
565040003437	DNA binding site [nucleotide binding]
565040003438	DEAD-like helicases superfamily; Region: DEXDc; smart00487
565040003439	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
565040003440	ATP binding site [chemical binding]; other site
565040003441	putative Mg++ binding site [ion binding]; other site
565040003442	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
565040003443	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
565040003444	nucleotide binding region [chemical binding]; other site
565040003445	ATP-binding site [chemical binding]; other site
565040003446	DEAD/H associated; Region: DEAD_assoc; pfam08494
565040003447	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
565040003448	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
565040003449	substrate binding site [chemical binding]; other site
565040003450	dimer interface [polypeptide binding]; other site
565040003451	ATP binding site [chemical binding]; other site
565040003452	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040003453	Major Facilitator Superfamily; Region: MFS_1; pfam07690
565040003454	putative substrate translocation pore; other site
565040003455	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
565040003456	Mg2+ binding site [ion binding]; other site
565040003457	G-X-G motif; other site
565040003458	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
565040003459	anchoring element; other site
565040003460	dimer interface [polypeptide binding]; other site
565040003461	ATP binding site [chemical binding]; other site
565040003462	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
565040003463	active site
565040003464	metal binding site [ion binding]; metal-binding site
565040003465	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
565040003466	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
565040003467	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
565040003468	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
565040003469	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
565040003470	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
565040003471	DNA binding residues [nucleotide binding]
565040003472	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
565040003473	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
565040003474	substrate binding pocket [chemical binding]; other site
565040003475	chain length determination region; other site
565040003476	substrate-Mg2+ binding site; other site
565040003477	catalytic residues [active]
565040003478	aspartate-rich region 1; other site
565040003479	active site lid residues [active]
565040003480	aspartate-rich region 2; other site
565040003481	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
565040003482	Catalytic domain of Protein Kinases; Region: PKc; cd00180
565040003483	active site
565040003484	ATP binding site [chemical binding]; other site
565040003485	substrate binding site [chemical binding]; other site
565040003486	activation loop (A-loop); other site
565040003487	PASTA domain; Region: PASTA; pfam03793
565040003488	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
565040003489	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
565040003490	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
565040003491	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
565040003492	putative acyl-acceptor binding pocket; other site
565040003493	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
565040003494	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
565040003495	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
565040003496	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
565040003497	Transposase; Region: DDE_Tnp_ISL3; pfam01610
565040003498	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
565040003499	DEAD/DEAH box helicase; Region: DEAD; pfam00270
565040003500	ATP binding site [chemical binding]; other site
565040003501	putative Mg++ binding site [ion binding]; other site
565040003502	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
565040003503	SEC-C motif; Region: SEC-C; pfam02810
565040003504	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
565040003505	30S subunit binding site; other site
565040003506	RecX family; Region: RecX; pfam02631
565040003507	recombinase A; Provisional; Region: recA; PRK09354
565040003508	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
565040003509	hexamer interface [polypeptide binding]; other site
565040003510	Walker A motif; other site
565040003511	ATP binding site [chemical binding]; other site
565040003512	Walker B motif; other site
565040003513	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
565040003514	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
565040003515	sequence-specific DNA binding site [nucleotide binding]; other site
565040003516	salt bridge; other site
565040003517	Competence-damaged protein; Region: CinA; pfam02464
565040003518	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
565040003519	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
565040003520	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
565040003521	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
565040003522	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
565040003523	Fic/DOC family; Region: Fic; cl00960
565040003524	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
565040003525	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
565040003526	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
565040003527	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
565040003528	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
565040003529	FeS/SAM binding site; other site
565040003530	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
565040003531	synthetase active site [active]
565040003532	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
565040003533	NTP binding site [chemical binding]; other site
565040003534	metal binding site [ion binding]; metal-binding site
565040003535	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
565040003536	EamA-like transporter family; Region: EamA; pfam00892
565040003537	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
565040003538	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
565040003539	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
565040003540	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
565040003541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
565040003542	active site
565040003543	phosphorylation site [posttranslational modification]
565040003544	intermolecular recognition site; other site
565040003545	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
565040003546	DNA binding residues [nucleotide binding]
565040003547	dimerization interface [polypeptide binding]; other site
565040003548	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
565040003549	Coenzyme A binding pocket [chemical binding]; other site
565040003550	Protein of unknown function DUF262; Region: DUF262; pfam03235
565040003551	Uncharacterized conserved protein [Function unknown]; Region: COG1479
565040003552	Protein of unknown function DUF262; Region: DUF262; pfam03235
565040003553	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
565040003554	RelB antitoxin; Region: RelB; cl01171
565040003555	aconitate hydratase; Validated; Region: PRK09277
565040003556	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
565040003557	substrate binding site [chemical binding]; other site
565040003558	ligand binding site [chemical binding]; other site
565040003559	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
565040003560	substrate binding site [chemical binding]; other site
565040003561	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
565040003562	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
565040003563	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040003564	motif II; other site
565040003565	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
565040003566	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
565040003567	TRAM domain; Region: TRAM; cl01282
565040003568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
565040003569	S-adenosylmethionine binding site [chemical binding]; other site
565040003570	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
565040003571	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
565040003572	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
565040003573	putative active site [active]
565040003574	putative catalytic site [active]
565040003575	putative DNA binding site [nucleotide binding]; other site
565040003576	putative phosphate binding site [ion binding]; other site
565040003577	metal binding site A [ion binding]; metal-binding site
565040003578	putative AP binding site [nucleotide binding]; other site
565040003579	putative metal binding site B [ion binding]; other site
565040003580	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
565040003581	AAA domain; Region: AAA_21; pfam13304
565040003582	Walker A/P-loop; other site
565040003583	ATP binding site [chemical binding]; other site
565040003584	Q-loop/lid; other site
565040003585	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
565040003586	ABC transporter signature motif; other site
565040003587	Walker B; other site
565040003588	D-loop; other site
565040003589	H-loop/switch region; other site
565040003590	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
565040003591	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
565040003592	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
565040003593	Walker A/P-loop; other site
565040003594	ATP binding site [chemical binding]; other site
565040003595	Q-loop/lid; other site
565040003596	ABC transporter signature motif; other site
565040003597	Walker B; other site
565040003598	D-loop; other site
565040003599	H-loop/switch region; other site
565040003600	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
565040003601	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
565040003602	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040003603	dimer interface [polypeptide binding]; other site
565040003604	conserved gate region; other site
565040003605	putative PBP binding loops; other site
565040003606	ABC-ATPase subunit interface; other site
565040003607	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
565040003608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040003609	dimer interface [polypeptide binding]; other site
565040003610	conserved gate region; other site
565040003611	putative PBP binding loops; other site
565040003612	ABC-ATPase subunit interface; other site
565040003613	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
565040003614	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
565040003615	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
565040003616	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
565040003617	active site
565040003618	DNA binding site [nucleotide binding]
565040003619	Int/Topo IB signature motif; other site
565040003620	Prephenate dehydrogenase; Region: PDH; pfam02153
565040003621	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
565040003622	prephenate dehydrogenase; Validated; Region: PRK08507
565040003623	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
565040003624	Prephenate dehydratase; Region: PDT; pfam00800
565040003625	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
565040003626	putative L-Phe binding site [chemical binding]; other site
565040003627	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
565040003628	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
565040003629	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
565040003630	G1 box; other site
565040003631	putative GEF interaction site [polypeptide binding]; other site
565040003632	GTP/Mg2+ binding site [chemical binding]; other site
565040003633	Switch I region; other site
565040003634	G2 box; other site
565040003635	G3 box; other site
565040003636	Switch II region; other site
565040003637	G4 box; other site
565040003638	G5 box; other site
565040003639	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
565040003640	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
565040003641	benzoate transport; Region: 2A0115; TIGR00895
565040003642	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040003643	putative substrate translocation pore; other site
565040003644	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
565040003645	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
565040003646	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
565040003647	catalytic residue [active]
565040003648	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543
565040003649	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
565040003650	dimerization interface [polypeptide binding]; other site
565040003651	active site
565040003652	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
565040003653	L-aspartate oxidase; Provisional; Region: PRK06175
565040003654	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
565040003655	quinolinate synthetase; Provisional; Region: PRK09375
565040003656	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
565040003657	nudix motif; other site
565040003658	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
565040003659	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
565040003660	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
565040003661	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
565040003662	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
565040003663	P-loop; other site
565040003664	Magnesium ion binding site [ion binding]; other site
565040003665	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
565040003666	Magnesium ion binding site [ion binding]; other site
565040003667	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
565040003668	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
565040003669	Walker A/P-loop; other site
565040003670	ATP binding site [chemical binding]; other site
565040003671	Q-loop/lid; other site
565040003672	ABC transporter signature motif; other site
565040003673	Walker B; other site
565040003674	D-loop; other site
565040003675	H-loop/switch region; other site
565040003676	FtsX-like permease family; Region: FtsX; pfam02687
565040003677	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
565040003678	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
565040003679	active site
565040003680	Int/Topo IB signature motif; other site
565040003681	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
565040003682	23S rRNA binding site [nucleotide binding]; other site
565040003683	L21 binding site [polypeptide binding]; other site
565040003684	L13 binding site [polypeptide binding]; other site
565040003685	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
565040003686	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
565040003687	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
565040003688	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
565040003689	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
565040003690	S-adenosylmethionine binding site [chemical binding]; other site
565040003691	Thiamine pyrophosphokinase; Region: TPK; cd07995
565040003692	active site
565040003693	dimerization interface [polypeptide binding]; other site
565040003694	thiamine binding site [chemical binding]; other site
565040003695	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
565040003696	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
565040003697	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
565040003698	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
565040003699	putative deacylase active site [active]
565040003700	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
565040003701	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
565040003702	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
565040003703	active site
565040003704	catalytic residues [active]
565040003705	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
565040003706	active site
565040003707	catalytic residues [active]
565040003708	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
565040003709	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
565040003710	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
565040003711	DNA binding residues [nucleotide binding]
565040003712	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
565040003713	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
565040003714	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
565040003715	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
565040003716	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
565040003717	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
565040003718	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
565040003719	Walker A/P-loop; other site
565040003720	ATP binding site [chemical binding]; other site
565040003721	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
565040003722	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
565040003723	ABC transporter signature motif; other site
565040003724	Walker B; other site
565040003725	D-loop; other site
565040003726	H-loop/switch region; other site
565040003727	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
565040003728	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
565040003729	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
565040003730	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
565040003731	proline aminopeptidase P II; Provisional; Region: PRK10879
565040003732	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
565040003733	active site
565040003734	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
565040003735	nudix motif; other site
565040003736	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
565040003737	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
565040003738	Walker A/P-loop; other site
565040003739	ATP binding site [chemical binding]; other site
565040003740	Q-loop/lid; other site
565040003741	ABC transporter signature motif; other site
565040003742	Walker B; other site
565040003743	D-loop; other site
565040003744	H-loop/switch region; other site
565040003745	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
565040003746	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
565040003747	Walker A/P-loop; other site
565040003748	ATP binding site [chemical binding]; other site
565040003749	Q-loop/lid; other site
565040003750	ABC transporter signature motif; other site
565040003751	Walker B; other site
565040003752	D-loop; other site
565040003753	H-loop/switch region; other site
565040003754	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
565040003755	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
565040003756	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040003757	dimer interface [polypeptide binding]; other site
565040003758	conserved gate region; other site
565040003759	ABC-ATPase subunit interface; other site
565040003760	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
565040003761	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040003762	dimer interface [polypeptide binding]; other site
565040003763	conserved gate region; other site
565040003764	putative PBP binding loops; other site
565040003765	ABC-ATPase subunit interface; other site
565040003766	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
565040003767	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
565040003768	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
565040003769	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
565040003770	active site
565040003771	dimer interface [polypeptide binding]; other site
565040003772	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
565040003773	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
565040003774	active site
565040003775	trimer interface [polypeptide binding]; other site
565040003776	allosteric site; other site
565040003777	active site lid [active]
565040003778	hexamer (dimer of trimers) interface [polypeptide binding]; other site
565040003779	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
565040003780	non-specific DNA interactions [nucleotide binding]; other site
565040003781	DNA binding site [nucleotide binding]
565040003782	sequence specific DNA binding site [nucleotide binding]; other site
565040003783	putative cAMP binding site [chemical binding]; other site
565040003784	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
565040003785	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
565040003786	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
565040003787	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
565040003788	nucleotide binding site [chemical binding]; other site
565040003789	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
565040003790	putative DNA binding site [nucleotide binding]; other site
565040003791	Transcriptional regulators [Transcription]; Region: MarR; COG1846
565040003792	putative Zn2+ binding site [ion binding]; other site
565040003793	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
565040003794	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
565040003795	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
565040003796	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
565040003797	putative substrate binding site [chemical binding]; other site
565040003798	putative ATP binding site [chemical binding]; other site
565040003799	Uncharacterized conserved protein [Function unknown]; Region: COG3538
565040003800	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
565040003801	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
565040003802	putative active cleft [active]
565040003803	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040003804	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040003805	DNA binding site [nucleotide binding]
565040003806	domain linker motif; other site
565040003807	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040003808	ligand binding site [chemical binding]; other site
565040003809	dimerization interface [polypeptide binding]; other site
565040003810	potential frameshift: common BLAST hit: gi|296454417|ref|YP_003661560.1| endo-beta-N-acetylglucosaminidase family protein
565040003811	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
565040003812	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
565040003813	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
565040003814	active site
565040003815	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
565040003816	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
565040003817	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
565040003818	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040003819	dimer interface [polypeptide binding]; other site
565040003820	conserved gate region; other site
565040003821	putative PBP binding loops; other site
565040003822	ABC-ATPase subunit interface; other site
565040003823	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040003824	dimer interface [polypeptide binding]; other site
565040003825	conserved gate region; other site
565040003826	putative PBP binding loops; other site
565040003827	ABC-ATPase subunit interface; other site
565040003828	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
565040003829	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
565040003830	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
565040003831	active site
565040003832	catalytic site [active]
565040003833	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
565040003834	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
565040003835	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
565040003836	active site
565040003837	catalytic site [active]
565040003838	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
565040003839	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
565040003840	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
565040003841	dimerization interface [polypeptide binding]; other site
565040003842	putative tRNAtyr binding site [nucleotide binding]; other site
565040003843	putative active site [active]
565040003844	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
565040003845	Cell division protein FtsQ; Region: FtsQ; pfam03799
565040003846	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
565040003847	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
565040003848	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
565040003849	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
565040003850	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
565040003851	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
565040003852	active site
565040003853	homodimer interface [polypeptide binding]; other site
565040003854	cell division protein FtsW; Region: ftsW; TIGR02614
565040003855	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
565040003856	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
565040003857	NAD binding site [chemical binding]; other site
565040003858	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
565040003859	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
565040003860	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
565040003861	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
565040003862	Mg++ binding site [ion binding]; other site
565040003863	putative catalytic motif [active]
565040003864	putative substrate binding site [chemical binding]; other site
565040003865	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
565040003866	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
565040003867	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
565040003868	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
565040003869	putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929
565040003870	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
565040003871	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
565040003872	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
565040003873	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
565040003874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
565040003875	S-adenosylmethionine binding site [chemical binding]; other site
565040003876	cell division protein MraZ; Reviewed; Region: PRK00326
565040003877	MraZ protein; Region: MraZ; pfam02381
565040003878	MraZ protein; Region: MraZ; pfam02381
565040003879	Part of AAA domain; Region: AAA_19; pfam13245
565040003880	Family description; Region: UvrD_C_2; pfam13538
565040003881	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
565040003882	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
565040003883	ligand binding site [chemical binding]; other site
565040003884	NAD binding site [chemical binding]; other site
565040003885	tetramer interface [polypeptide binding]; other site
565040003886	catalytic site [active]
565040003887	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
565040003888	L-serine binding site [chemical binding]; other site
565040003889	ACT domain interface; other site
565040003890	ATP cone domain; Region: ATP-cone; pfam03477
565040003891	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
565040003892	LexA repressor; Validated; Region: PRK00215
565040003893	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
565040003894	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
565040003895	Catalytic site [active]
565040003896	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
565040003897	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
565040003898	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
565040003899	NAD binding site [chemical binding]; other site
565040003900	dimer interface [polypeptide binding]; other site
565040003901	substrate binding site [chemical binding]; other site
565040003902	tetramer (dimer of dimers) interface [polypeptide binding]; other site
565040003903	GTPases [General function prediction only]; Region: HflX; COG2262
565040003904	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
565040003905	HflX GTPase family; Region: HflX; cd01878
565040003906	G1 box; other site
565040003907	GTP/Mg2+ binding site [chemical binding]; other site
565040003908	Switch I region; other site
565040003909	G2 box; other site
565040003910	G3 box; other site
565040003911	Switch II region; other site
565040003912	G4 box; other site
565040003913	G5 box; other site
565040003914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
565040003915	S-adenosylmethionine binding site [chemical binding]; other site
565040003916	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
565040003917	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
565040003918	ATP binding site [chemical binding]; other site
565040003919	putative Mg++ binding site [ion binding]; other site
565040003920	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
565040003921	nucleotide binding region [chemical binding]; other site
565040003922	ATP-binding site [chemical binding]; other site
565040003923	Helicase associated domain (HA2); Region: HA2; pfam04408
565040003924	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
565040003925	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
565040003926	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
565040003927	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
565040003928	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
565040003929	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
565040003930	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
565040003931	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
565040003932	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
565040003933	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
565040003934	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
565040003935	catalytic residues [active]
565040003936	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
565040003937	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
565040003938	putative active site [active]
565040003939	oxyanion strand; other site
565040003940	catalytic triad [active]
565040003941	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
565040003942	putative active site pocket [active]
565040003943	4-fold oligomerization interface [polypeptide binding]; other site
565040003944	metal binding residues [ion binding]; metal-binding site
565040003945	3-fold/trimer interface [polypeptide binding]; other site
565040003946	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
565040003947	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
565040003948	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040003949	homodimer interface [polypeptide binding]; other site
565040003950	catalytic residue [active]
565040003951	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
565040003952	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
565040003953	NAD binding site [chemical binding]; other site
565040003954	dimerization interface [polypeptide binding]; other site
565040003955	product binding site; other site
565040003956	substrate binding site [chemical binding]; other site
565040003957	zinc binding site [ion binding]; other site
565040003958	catalytic residues [active]
565040003959	Acylphosphatase; Region: Acylphosphatase; cl00551
565040003960	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
565040003961	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
565040003962	nucleotide binding site [chemical binding]; other site
565040003963	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040003964	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040003965	Integrase core domain; Region: rve; pfam00665
565040003966	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
565040003967	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
565040003968	active site
565040003969	catalytic tetrad [active]
565040003970	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
565040003971	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
565040003972	Coenzyme A binding pocket [chemical binding]; other site
565040003973	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040003974	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040003975	Integrase core domain; Region: rve; pfam00665
565040003976	myosin-cross-reactive antigen; Provisional; Region: PRK13977
565040003977	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
565040003978	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
565040003979	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
565040003980	active site
565040003981	PHP Thumb interface [polypeptide binding]; other site
565040003982	metal binding site [ion binding]; metal-binding site
565040003983	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
565040003984	generic binding surface II; other site
565040003985	generic binding surface I; other site
565040003986	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040003987	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040003988	Integrase core domain; Region: rve; pfam00665
565040003989	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
565040003990	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
565040003991	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
565040003992	active site
565040003993	lipoprotein signal peptidase; Provisional; Region: PRK14771
565040003994	DivIVA protein; Region: DivIVA; pfam05103
565040003995	DivIVA domain; Region: DivI1A_domain; TIGR03544
565040003996	YGGT family; Region: YGGT; pfam02325
565040003997	Protein of unknown function (DUF552); Region: DUF552; pfam04472
565040003998	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
565040003999	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
565040004000	nucleotide binding site [chemical binding]; other site
565040004001	SulA interaction site; other site
565040004002	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
565040004003	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
565040004004	FMN binding site [chemical binding]; other site
565040004005	active site
565040004006	catalytic residues [active]
565040004007	substrate binding site [chemical binding]; other site
565040004008	glycyl-tRNA synthetase; Provisional; Region: PRK04173
565040004009	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
565040004010	motif 1; other site
565040004011	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
565040004012	active site
565040004013	motif 2; other site
565040004014	motif 3; other site
565040004015	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
565040004016	anticodon binding site; other site
565040004017	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
565040004018	substrate binding site [chemical binding]; other site
565040004019	multimerization interface [polypeptide binding]; other site
565040004020	ATP binding site [chemical binding]; other site
565040004021	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
565040004022	thiamine phosphate binding site [chemical binding]; other site
565040004023	active site
565040004024	pyrophosphate binding site [ion binding]; other site
565040004025	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
565040004026	ThiC-associated domain; Region: ThiC-associated; pfam13667
565040004027	ThiC family; Region: ThiC; pfam01964
565040004028	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
565040004029	substrate binding site [chemical binding]; other site
565040004030	dimer interface [polypeptide binding]; other site
565040004031	ATP binding site [chemical binding]; other site
565040004032	Domain of unknown function DUF77; Region: DUF77; pfam01910
565040004033	benzoate transport; Region: 2A0115; TIGR00895
565040004034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040004035	putative substrate translocation pore; other site
565040004036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040004037	putative substrate translocation pore; other site
565040004038	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172
565040004039	serpin-like protein; Provisional; Region: PHA02660
565040004040	reactive center loop; other site
565040004041	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040004042	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040004043	DNA binding site [nucleotide binding]
565040004044	domain linker motif; other site
565040004045	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
565040004046	putative dimerization interface [polypeptide binding]; other site
565040004047	putative ligand binding site [chemical binding]; other site
565040004048	galactoside permease; Reviewed; Region: lacY; PRK09528
565040004049	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040004050	putative substrate translocation pore; other site
565040004051	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
565040004052	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
565040004053	substrate binding [chemical binding]; other site
565040004054	active site
565040004055	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
565040004056	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
565040004057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040004058	dimer interface [polypeptide binding]; other site
565040004059	conserved gate region; other site
565040004060	putative PBP binding loops; other site
565040004061	ABC-ATPase subunit interface; other site
565040004062	NMT1/THI5 like; Region: NMT1; pfam09084
565040004063	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
565040004064	active site
565040004065	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
565040004066	active site
565040004067	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829
565040004068	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
565040004069	catalytic residue [active]
565040004070	putative FPP diphosphate  binding site; other site
565040004071	putative FPP binding hydrophobic cleft; other site
565040004072	dimer interface [polypeptide binding]; other site
565040004073	putative IPP diphosphate binding site; other site
565040004074	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
565040004075	Recombination protein O N terminal; Region: RecO_N; pfam11967
565040004076	Recombination protein O C terminal; Region: RecO_C; pfam02565
565040004077	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
565040004078	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
565040004079	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
565040004080	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
565040004081	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
565040004082	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
565040004083	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
565040004084	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
565040004085	DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543
565040004086	DivIVA domain; Region: DivI1A_domain; TIGR03544
565040004087	DivIVA domain; Region: DivI1A_domain; TIGR03544
565040004088	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
565040004089	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
565040004090	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
565040004091	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
565040004092	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
565040004093	Part of AAA domain; Region: AAA_19; pfam13245
565040004094	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
565040004095	Family description; Region: UvrD_C_2; pfam13538
565040004096	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
565040004097	substrate binding site [chemical binding]; other site
565040004098	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
565040004099	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
565040004100	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
565040004101	active site
565040004102	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
565040004103	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
565040004104	putative active site [active]
565040004105	redox center [active]
565040004106	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
565040004107	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
565040004108	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
565040004109	glutamate racemase; Provisional; Region: PRK00865
565040004110	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
565040004111	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
565040004112	active site
565040004113	nucleophile elbow; other site
565040004114	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
565040004115	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
565040004116	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
565040004117	NIL domain; Region: NIL; pfam09383
565040004118	Zinc-binding dehydrogenase; Region: ADH_zinc_N_2; pfam13602
565040004119	Predicted transcriptional regulator [Transcription]; Region: COG1959
565040004120	Transcriptional regulator; Region: Rrf2; cl17282
565040004121	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
565040004122	catalytic residues [active]
565040004123	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
565040004124	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
565040004125	homodimer interface [polypeptide binding]; other site
565040004126	substrate-cofactor binding pocket; other site
565040004127	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040004128	catalytic residue [active]
565040004129	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
565040004130	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
565040004131	substrate binding pocket [chemical binding]; other site
565040004132	membrane-bound complex binding site; other site
565040004133	hinge residues; other site
565040004134	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
565040004135	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
565040004136	Walker A/P-loop; other site
565040004137	ATP binding site [chemical binding]; other site
565040004138	Q-loop/lid; other site
565040004139	ABC transporter signature motif; other site
565040004140	Walker B; other site
565040004141	D-loop; other site
565040004142	H-loop/switch region; other site
565040004143	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
565040004144	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040004145	dimer interface [polypeptide binding]; other site
565040004146	conserved gate region; other site
565040004147	putative PBP binding loops; other site
565040004148	ABC-ATPase subunit interface; other site
565040004149	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
565040004150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040004151	dimer interface [polypeptide binding]; other site
565040004152	conserved gate region; other site
565040004153	putative PBP binding loops; other site
565040004154	ABC-ATPase subunit interface; other site
565040004155	Predicted esterase [General function prediction only]; Region: COG0400
565040004156	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
565040004157	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
565040004158	translation elongation factor EF-G; Region: EF-G; TIGR00484
565040004159	G1 box; other site
565040004160	putative GEF interaction site [polypeptide binding]; other site
565040004161	GTP/Mg2+ binding site [chemical binding]; other site
565040004162	Switch I region; other site
565040004163	G2 box; other site
565040004164	G3 box; other site
565040004165	Switch II region; other site
565040004166	G4 box; other site
565040004167	G5 box; other site
565040004168	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
565040004169	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
565040004170	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
565040004171	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
565040004172	active site
565040004173	catalytic site [active]
565040004174	substrate binding site [chemical binding]; other site
565040004175	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
565040004176	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
565040004177	catalytic site [active]
565040004178	G-X2-G-X-G-K; other site
565040004179	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
565040004180	active site
565040004181	dimer interface [polypeptide binding]; other site
565040004182	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
565040004183	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
565040004184	ATP-grasp domain; Region: ATP-grasp_4; cl17255
565040004185	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
565040004186	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
565040004187	ATP-grasp domain; Region: ATP-grasp_4; cl17255
565040004188	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
565040004189	IMP binding site; other site
565040004190	dimer interface [polypeptide binding]; other site
565040004191	interdomain contacts; other site
565040004192	partial ornithine binding site; other site
565040004193	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
565040004194	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
565040004195	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
565040004196	catalytic site [active]
565040004197	subunit interface [polypeptide binding]; other site
565040004198	transcription antitermination factor NusB; Region: nusB; TIGR01951
565040004199	putative RNA binding site [nucleotide binding]; other site
565040004200	elongation factor P; Validated; Region: PRK00529
565040004201	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
565040004202	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
565040004203	RNA binding site [nucleotide binding]; other site
565040004204	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
565040004205	RNA binding site [nucleotide binding]; other site
565040004206	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
565040004207	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040004208	Walker A/P-loop; other site
565040004209	ATP binding site [chemical binding]; other site
565040004210	Q-loop/lid; other site
565040004211	ABC transporter signature motif; other site
565040004212	Walker B; other site
565040004213	D-loop; other site
565040004214	H-loop/switch region; other site
565040004215	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
565040004216	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
565040004217	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
565040004218	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
565040004219	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
565040004220	S-adenosylmethionine binding site [chemical binding]; other site
565040004221	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
565040004222	catalytic residues [active]
565040004223	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
565040004224	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
565040004225	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
565040004226	putative alpha-glucosidase; Provisional; Region: PRK10658
565040004227	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
565040004228	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
565040004229	active site
565040004230	catalytic site [active]
565040004231	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
565040004232	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
565040004233	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
565040004234	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
565040004235	putative active site [active]
565040004236	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
565040004237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040004238	dimer interface [polypeptide binding]; other site
565040004239	conserved gate region; other site
565040004240	ABC-ATPase subunit interface; other site
565040004241	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040004242	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
565040004243	Domain of unknown function DUF59; Region: DUF59; cl00941
565040004244	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
565040004245	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
565040004246	Walker A motif; other site
565040004247	Ligase N family; Region: LIGANc; smart00532
565040004248	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
565040004249	nucleotide binding pocket [chemical binding]; other site
565040004250	K-X-D-G motif; other site
565040004251	catalytic site [active]
565040004252	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
565040004253	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
565040004254	Helix-hairpin-helix motif; Region: HHH; pfam00633
565040004255	helix-hairpin-helix signature motif; other site
565040004256	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
565040004257	Dimer interface [polypeptide binding]; other site
565040004258	TPR repeat; Region: TPR_11; pfam13414
565040004259	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
565040004260	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040004261	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
565040004262	Walker A/P-loop; other site
565040004263	ATP binding site [chemical binding]; other site
565040004264	ABC transporter signature motif; other site
565040004265	Walker B; other site
565040004266	D-loop; other site
565040004267	H-loop/switch region; other site
565040004268	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
565040004269	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
565040004270	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040004271	homodimer interface [polypeptide binding]; other site
565040004272	catalytic residue [active]
565040004273	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
565040004274	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
565040004275	nucleotide binding site [chemical binding]; other site
565040004276	Nitroreductase family; Region: Nitroreductase; pfam00881
565040004277	FMN binding site [chemical binding]; other site
565040004278	dimer interface [polypeptide binding]; other site
565040004279	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
565040004280	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
565040004281	Probable Catalytic site; other site
565040004282	Predicted membrane protein [Function unknown]; Region: COG3601
565040004283	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
565040004284	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
565040004285	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
565040004286	Walker A/P-loop; other site
565040004287	ATP binding site [chemical binding]; other site
565040004288	Q-loop/lid; other site
565040004289	ABC transporter signature motif; other site
565040004290	Walker B; other site
565040004291	D-loop; other site
565040004292	H-loop/switch region; other site
565040004293	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
565040004294	Walker A/P-loop; other site
565040004295	ATP binding site [chemical binding]; other site
565040004296	Q-loop/lid; other site
565040004297	ABC transporter signature motif; other site
565040004298	Walker B; other site
565040004299	D-loop; other site
565040004300	H-loop/switch region; other site
565040004301	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
565040004302	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
565040004303	Membrane protein of unknown function; Region: DUF360; pfam04020
565040004304	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
565040004305	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
565040004306	NAD binding site [chemical binding]; other site
565040004307	ligand binding site [chemical binding]; other site
565040004308	catalytic site [active]
565040004309	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040004310	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
565040004311	putative substrate translocation pore; other site
565040004312	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
565040004313	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
565040004314	TM-ABC transporter signature motif; other site
565040004315	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
565040004316	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
565040004317	TM-ABC transporter signature motif; other site
565040004318	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
565040004319	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
565040004320	Walker A/P-loop; other site
565040004321	ATP binding site [chemical binding]; other site
565040004322	Q-loop/lid; other site
565040004323	ABC transporter signature motif; other site
565040004324	Walker B; other site
565040004325	D-loop; other site
565040004326	H-loop/switch region; other site
565040004327	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
565040004328	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
565040004329	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
565040004330	lipoprotein LpqB; Provisional; Region: PRK13613
565040004331	Sporulation and spore germination; Region: Germane; pfam10646
565040004332	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
565040004333	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
565040004334	dimerization interface [polypeptide binding]; other site
565040004335	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
565040004336	dimer interface [polypeptide binding]; other site
565040004337	phosphorylation site [posttranslational modification]
565040004338	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
565040004339	ATP binding site [chemical binding]; other site
565040004340	Mg2+ binding site [ion binding]; other site
565040004341	G-X-G motif; other site
565040004342	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
565040004343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
565040004344	active site
565040004345	phosphorylation site [posttranslational modification]
565040004346	intermolecular recognition site; other site
565040004347	dimerization interface [polypeptide binding]; other site
565040004348	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
565040004349	DNA binding site [nucleotide binding]
565040004350	recombination factor protein RarA; Reviewed; Region: PRK13342
565040004351	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040004352	Walker A motif; other site
565040004353	ATP binding site [chemical binding]; other site
565040004354	Walker B motif; other site
565040004355	arginine finger; other site
565040004356	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
565040004357	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
565040004358	ATP binding site [chemical binding]; other site
565040004359	putative Mg++ binding site [ion binding]; other site
565040004360	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
565040004361	nucleotide binding region [chemical binding]; other site
565040004362	ATP-binding site [chemical binding]; other site
565040004363	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
565040004364	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
565040004365	Lamin Tail Domain; Region: LTD; pfam00932
565040004366	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
565040004367	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
565040004368	active site
565040004369	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040004370	dimer interface [polypeptide binding]; other site
565040004371	conserved gate region; other site
565040004372	putative PBP binding loops; other site
565040004373	ABC-ATPase subunit interface; other site
565040004374	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040004375	dimer interface [polypeptide binding]; other site
565040004376	conserved gate region; other site
565040004377	ABC-ATPase subunit interface; other site
565040004378	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
565040004379	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
565040004380	substrate binding pocket [chemical binding]; other site
565040004381	membrane-bound complex binding site; other site
565040004382	hinge residues; other site
565040004383	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
565040004384	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
565040004385	Walker A/P-loop; other site
565040004386	ATP binding site [chemical binding]; other site
565040004387	Q-loop/lid; other site
565040004388	ABC transporter signature motif; other site
565040004389	Walker B; other site
565040004390	D-loop; other site
565040004391	H-loop/switch region; other site
565040004392	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
565040004393	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
565040004394	dimer interface [polypeptide binding]; other site
565040004395	anticodon binding site; other site
565040004396	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
565040004397	motif 1; other site
565040004398	dimer interface [polypeptide binding]; other site
565040004399	active site
565040004400	motif 2; other site
565040004401	GAD domain; Region: GAD; pfam02938
565040004402	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
565040004403	active site
565040004404	motif 3; other site
565040004405	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
565040004406	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
565040004407	dimer interface [polypeptide binding]; other site
565040004408	motif 1; other site
565040004409	active site
565040004410	motif 2; other site
565040004411	motif 3; other site
565040004412	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
565040004413	anticodon binding site; other site
565040004414	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
565040004415	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
565040004416	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
565040004417	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
565040004418	active site
565040004419	metal binding site [ion binding]; metal-binding site
565040004420	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
565040004421	Creatinine amidohydrolase; Region: Creatininase; pfam02633
565040004422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040004423	metabolite-proton symporter; Region: 2A0106; TIGR00883
565040004424	putative substrate translocation pore; other site
565040004425	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
565040004426	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
565040004427	cytosine deaminase; Provisional; Region: PRK09230
565040004428	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
565040004429	active site
565040004430	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
565040004431	Clp amino terminal domain; Region: Clp_N; pfam02861
565040004432	Clp amino terminal domain; Region: Clp_N; pfam02861
565040004433	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040004434	Walker A motif; other site
565040004435	ATP binding site [chemical binding]; other site
565040004436	Walker B motif; other site
565040004437	arginine finger; other site
565040004438	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040004439	Walker A motif; other site
565040004440	ATP binding site [chemical binding]; other site
565040004441	Walker B motif; other site
565040004442	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
565040004443	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
565040004444	Ligand Binding Site [chemical binding]; other site
565040004445	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
565040004446	Ligand Binding Site [chemical binding]; other site
565040004447	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
565040004448	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
565040004449	DNA-binding site [nucleotide binding]; DNA binding site
565040004450	RNA-binding motif; other site
565040004451	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
565040004452	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
565040004453	dimerization interface [polypeptide binding]; other site
565040004454	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
565040004455	dimer interface [polypeptide binding]; other site
565040004456	phosphorylation site [posttranslational modification]
565040004457	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
565040004458	ATP binding site [chemical binding]; other site
565040004459	Mg2+ binding site [ion binding]; other site
565040004460	G-X-G motif; other site
565040004461	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
565040004462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
565040004463	active site
565040004464	phosphorylation site [posttranslational modification]
565040004465	intermolecular recognition site; other site
565040004466	dimerization interface [polypeptide binding]; other site
565040004467	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
565040004468	DNA binding site [nucleotide binding]
565040004469	Repair protein; Region: Repair_PSII; cl01535
565040004470	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
565040004471	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
565040004472	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
565040004473	ring oligomerisation interface [polypeptide binding]; other site
565040004474	ATP/Mg binding site [chemical binding]; other site
565040004475	stacking interactions; other site
565040004476	hinge regions; other site
565040004477	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
565040004478	DNA-binding site [nucleotide binding]; DNA binding site
565040004479	RNA-binding motif; other site
565040004480	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
565040004481	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
565040004482	ligand binding site [chemical binding]; other site
565040004483	active site
565040004484	UGI interface [polypeptide binding]; other site
565040004485	catalytic site [active]
565040004486	MoxR-like ATPases [General function prediction only]; Region: COG0714
565040004487	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
565040004488	Protein of unknown function DUF58; Region: DUF58; pfam01882
565040004489	von Willebrand factor type A domain; Region: VWA_2; pfam13519
565040004490	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
565040004491	metal ion-dependent adhesion site (MIDAS); other site
565040004492	PGAP1-like protein; Region: PGAP1; pfam07819
565040004493	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
565040004494	adenylosuccinate lyase; Provisional; Region: PRK09285
565040004495	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
565040004496	tetramer interface [polypeptide binding]; other site
565040004497	active site
565040004498	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
565040004499	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
565040004500	IHF dimer interface [polypeptide binding]; other site
565040004501	IHF - DNA interface [nucleotide binding]; other site
565040004502	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
565040004503	Pup-like protein; Region: Pup; cl05289
565040004504	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
565040004505	active site
565040004506	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
565040004507	Pup-ligase protein; Region: Pup_ligase; cl15463
565040004508	proteasome ATPase; Region: pup_AAA; TIGR03689
565040004509	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040004510	Walker A motif; other site
565040004511	ATP binding site [chemical binding]; other site
565040004512	Walker B motif; other site
565040004513	arginine finger; other site
565040004514	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
565040004515	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
565040004516	phosphoserine phosphatase SerB; Region: serB; TIGR00338
565040004517	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040004518	motif II; other site
565040004519	primosome assembly protein PriA; Provisional; Region: PRK14873
565040004520	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
565040004521	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040004522	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
565040004523	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
565040004524	putative active site [active]
565040004525	substrate binding site [chemical binding]; other site
565040004526	putative cosubstrate binding site; other site
565040004527	catalytic site [active]
565040004528	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
565040004529	substrate binding site [chemical binding]; other site
565040004530	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
565040004531	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
565040004532	S-adenosylmethionine synthetase; Validated; Region: PRK05250
565040004533	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
565040004534	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
565040004535	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
565040004536	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
565040004537	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
565040004538	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
565040004539	ATP binding site [chemical binding]; other site
565040004540	putative Mg++ binding site [ion binding]; other site
565040004541	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
565040004542	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
565040004543	Divergent AAA domain; Region: AAA_4; pfam04326
565040004544	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
565040004545	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
565040004546	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
565040004547	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
565040004548	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
565040004549	HsdM N-terminal domain; Region: HsdM_N; pfam12161
565040004550	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
565040004551	Methyltransferase domain; Region: Methyltransf_26; pfam13659
565040004552	Restriction endonuclease; Region: Mrr_cat; pfam04471
565040004553	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
565040004554	Int/Topo IB signature motif; other site
565040004555	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
565040004556	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
565040004557	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
565040004558	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
565040004559	HIGH motif; other site
565040004560	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
565040004561	active site
565040004562	KMSKS motif; other site
565040004563	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
565040004564	tRNA binding surface [nucleotide binding]; other site
565040004565	anticodon binding site; other site
565040004566	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
565040004567	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
565040004568	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040004569	homodimer interface [polypeptide binding]; other site
565040004570	catalytic residue [active]
565040004571	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
565040004572	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040004573	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040004574	DNA binding site [nucleotide binding]
565040004575	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
565040004576	putative dimerization interface [polypeptide binding]; other site
565040004577	putative ligand binding site [chemical binding]; other site
565040004578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040004579	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
565040004580	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
565040004581	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
565040004582	substrate binding site [chemical binding]; other site
565040004583	ATP binding site [chemical binding]; other site
565040004584	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
565040004585	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
565040004586	dimer interface [polypeptide binding]; other site
565040004587	active site
565040004588	metal binding site [ion binding]; metal-binding site
565040004589	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
565040004590	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
565040004591	motif II; other site
565040004592	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
565040004593	active site
565040004594	tetramer interface [polypeptide binding]; other site
565040004595	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
565040004596	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
565040004597	substrate binding site [chemical binding]; other site
565040004598	ATP binding site [chemical binding]; other site
565040004599	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
565040004600	active site
565040004601	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
565040004602	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
565040004603	Walker A/P-loop; other site
565040004604	ATP binding site [chemical binding]; other site
565040004605	Q-loop/lid; other site
565040004606	ABC transporter signature motif; other site
565040004607	Walker B; other site
565040004608	D-loop; other site
565040004609	H-loop/switch region; other site
565040004610	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
565040004611	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
565040004612	Walker A/P-loop; other site
565040004613	ATP binding site [chemical binding]; other site
565040004614	Q-loop/lid; other site
565040004615	ABC transporter signature motif; other site
565040004616	Walker B; other site
565040004617	D-loop; other site
565040004618	H-loop/switch region; other site
565040004619	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
565040004620	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040004621	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040004622	DNA binding site [nucleotide binding]
565040004623	domain linker motif; other site
565040004624	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040004625	dimerization interface [polypeptide binding]; other site
565040004626	ligand binding site [chemical binding]; other site
565040004627	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
565040004628	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
565040004629	substrate binding site [chemical binding]; other site
565040004630	dimer interface [polypeptide binding]; other site
565040004631	ATP binding site [chemical binding]; other site
565040004632	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
565040004633	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
565040004634	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
565040004635	Walker A/P-loop; other site
565040004636	ATP binding site [chemical binding]; other site
565040004637	Q-loop/lid; other site
565040004638	ABC transporter signature motif; other site
565040004639	Walker B; other site
565040004640	D-loop; other site
565040004641	H-loop/switch region; other site
565040004642	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
565040004643	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
565040004644	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040004645	Walker A/P-loop; other site
565040004646	ATP binding site [chemical binding]; other site
565040004647	Q-loop/lid; other site
565040004648	ABC transporter signature motif; other site
565040004649	Walker B; other site
565040004650	D-loop; other site
565040004651	H-loop/switch region; other site
565040004652	Transcriptional regulators [Transcription]; Region: MarR; COG1846
565040004653	MarR family; Region: MarR_2; pfam12802
565040004654	MarR family; Region: MarR_2; cl17246
565040004655	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
565040004656	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
565040004657	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
565040004658	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
565040004659	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
565040004660	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
565040004661	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
565040004662	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
565040004663	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
565040004664	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
565040004665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040004666	Major Facilitator Superfamily; Region: MFS_1; pfam07690
565040004667	putative substrate translocation pore; other site
565040004668	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
565040004669	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
565040004670	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
565040004671	nucleotidyltransferase substrate binding protein, HI0074 family; Region: HI0074; TIGR01987
565040004672	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
565040004673	active site
565040004674	NTP binding site [chemical binding]; other site
565040004675	metal binding triad [ion binding]; metal-binding site
565040004676	antibiotic binding site [chemical binding]; other site
565040004677	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
565040004678	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
565040004679	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
565040004680	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
565040004681	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
565040004682	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
565040004683	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
565040004684	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
565040004685	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
565040004686	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
565040004687	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
565040004688	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
565040004689	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
565040004690	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
565040004691	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
565040004692	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
565040004693	ATP cone domain; Region: ATP-cone; pfam03477
565040004694	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
565040004695	Class III ribonucleotide reductase; Region: RNR_III; cd01675
565040004696	active site
565040004697	Zn binding site [ion binding]; other site
565040004698	glycine loop; other site
565040004699	oxidoreductase; Region: PLN02835
565040004700	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
565040004701	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
565040004702	generic binding surface II; other site
565040004703	generic binding surface I; other site
565040004704	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
565040004705	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
565040004706	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
565040004707	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
565040004708	acyl-activating enzyme (AAE) consensus motif; other site
565040004709	putative AMP binding site [chemical binding]; other site
565040004710	putative active site [active]
565040004711	putative CoA binding site [chemical binding]; other site
565040004712	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
565040004713	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
565040004714	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
565040004715	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
565040004716	Coenzyme A binding pocket [chemical binding]; other site
565040004717	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
565040004718	putative catalytic site [active]
565040004719	putative metal binding site [ion binding]; other site
565040004720	putative phosphate binding site [ion binding]; other site
565040004721	exopolyphosphatase; Region: exo_poly_only; TIGR03706
565040004722	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
565040004723	nucleotide binding site [chemical binding]; other site
565040004724	hypothetical protein; Provisional; Region: PRK08960
565040004725	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
565040004726	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040004727	homodimer interface [polypeptide binding]; other site
565040004728	catalytic residue [active]
565040004729	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
565040004730	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
565040004731	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
565040004732	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
565040004733	additional DNA contacts [nucleotide binding]; other site
565040004734	mismatch recognition site; other site
565040004735	active site
565040004736	zinc binding site [ion binding]; other site
565040004737	DNA intercalation site [nucleotide binding]; other site
565040004738	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
565040004739	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
565040004740	Coenzyme A binding pocket [chemical binding]; other site
565040004741	SWIM zinc finger; Region: SWIM; pfam04434
565040004742	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
565040004743	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
565040004744	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
565040004745	ATP binding site [chemical binding]; other site
565040004746	putative Mg++ binding site [ion binding]; other site
565040004747	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
565040004748	nucleotide binding region [chemical binding]; other site
565040004749	ATP-binding site [chemical binding]; other site
565040004750	Penicillinase repressor; Region: Pencillinase_R; cl17580
565040004751	WYL domain; Region: WYL; pfam13280
565040004752	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
565040004753	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
565040004754	putative trimer interface [polypeptide binding]; other site
565040004755	putative CoA binding site [chemical binding]; other site
565040004756	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
565040004757	Citrate synthase; Region: Citrate_synt; pfam00285
565040004758	oxalacetate binding site [chemical binding]; other site
565040004759	citrylCoA binding site [chemical binding]; other site
565040004760	coenzyme A binding site [chemical binding]; other site
565040004761	catalytic triad [active]
565040004762	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
565040004763	active site
565040004764	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
565040004765	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
565040004766	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
565040004767	active site
565040004768	Zn binding site [ion binding]; other site
565040004769	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
565040004770	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
565040004771	dimer interface [polypeptide binding]; other site
565040004772	ssDNA binding site [nucleotide binding]; other site
565040004773	tetramer (dimer of dimers) interface [polypeptide binding]; other site
565040004774	prolyl-tRNA synthetase; Provisional; Region: PRK09194
565040004775	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
565040004776	dimer interface [polypeptide binding]; other site
565040004777	motif 1; other site
565040004778	active site
565040004779	motif 2; other site
565040004780	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
565040004781	putative deacylase active site [active]
565040004782	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
565040004783	active site
565040004784	motif 3; other site
565040004785	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
565040004786	anticodon binding site; other site
565040004787	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
565040004788	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
565040004789	FeS/SAM binding site; other site
565040004790	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
565040004791	putative ligand binding pocket/active site [active]
565040004792	putative metal binding site [ion binding]; other site
565040004793	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
565040004794	AMMECR1; Region: AMMECR1; pfam01871
565040004795	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
565040004796	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040004797	PIF1-like helicase; Region: PIF1; pfam05970
565040004798	Walker A motif; other site
565040004799	ATP binding site [chemical binding]; other site
565040004800	Walker B motif; other site
565040004801	arginine finger; other site
565040004802	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
565040004803	catalytic site [active]
565040004804	putative active site [active]
565040004805	putative substrate binding site [chemical binding]; other site
565040004806	dimer interface [polypeptide binding]; other site
565040004807	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
565040004808	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
565040004809	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
565040004810	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
565040004811	active site
565040004812	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
565040004813	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
565040004814	Mg++ binding site [ion binding]; other site
565040004815	putative catalytic motif [active]
565040004816	substrate binding site [chemical binding]; other site
565040004817	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
565040004818	maltose O-acetyltransferase; Provisional; Region: PRK10092
565040004819	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
565040004820	active site
565040004821	substrate binding site [chemical binding]; other site
565040004822	trimer interface [polypeptide binding]; other site
565040004823	CoA binding site [chemical binding]; other site
565040004824	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
565040004825	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
565040004826	Walker A/P-loop; other site
565040004827	ATP binding site [chemical binding]; other site
565040004828	Q-loop/lid; other site
565040004829	ABC transporter signature motif; other site
565040004830	Walker B; other site
565040004831	D-loop; other site
565040004832	H-loop/switch region; other site
565040004833	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
565040004834	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
565040004835	Walker A/P-loop; other site
565040004836	ATP binding site [chemical binding]; other site
565040004837	Q-loop/lid; other site
565040004838	ABC transporter signature motif; other site
565040004839	Walker B; other site
565040004840	D-loop; other site
565040004841	H-loop/switch region; other site
565040004842	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
565040004843	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
565040004844	TM-ABC transporter signature motif; other site
565040004845	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
565040004846	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
565040004847	TM-ABC transporter signature motif; other site
565040004848	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
565040004849	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
565040004850	putative ligand binding site [chemical binding]; other site
565040004851	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
565040004852	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
565040004853	S-adenosylmethionine binding site [chemical binding]; other site
565040004854	peptide chain release factor 1; Validated; Region: prfA; PRK00591
565040004855	This domain is found in peptide chain release factors; Region: PCRF; smart00937
565040004856	RF-1 domain; Region: RF-1; pfam00472
565040004857	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
565040004858	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
565040004859	non-specific DNA interactions [nucleotide binding]; other site
565040004860	DNA binding site [nucleotide binding]
565040004861	sequence specific DNA binding site [nucleotide binding]; other site
565040004862	putative cAMP binding site [chemical binding]; other site
565040004863	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
565040004864	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
565040004865	D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
565040004866	N- and C-terminal domain interface [polypeptide binding]; other site
565040004867	D-xylulose kinase; Region: XylB; TIGR01312
565040004868	active site
565040004869	MgATP binding site [chemical binding]; other site
565040004870	catalytic site [active]
565040004871	metal binding site [ion binding]; metal-binding site
565040004872	xylulose binding site [chemical binding]; other site
565040004873	putative homodimer interface [polypeptide binding]; other site
565040004874	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
565040004875	trimer interface [polypeptide binding]; other site
565040004876	active site
565040004877	substrate binding site [chemical binding]; other site
565040004878	CoA binding site [chemical binding]; other site
565040004879	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
565040004880	active site
565040004881	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
565040004882	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
565040004883	inhibitor binding site; inhibition site
565040004884	active site
565040004885	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
565040004886	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
565040004887	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040004888	dimer interface [polypeptide binding]; other site
565040004889	conserved gate region; other site
565040004890	putative PBP binding loops; other site
565040004891	ABC-ATPase subunit interface; other site
565040004892	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
565040004893	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040004894	dimer interface [polypeptide binding]; other site
565040004895	conserved gate region; other site
565040004896	putative PBP binding loops; other site
565040004897	ABC-ATPase subunit interface; other site
565040004898	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
565040004899	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
565040004900	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040004901	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040004902	DNA binding site [nucleotide binding]
565040004903	Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296
565040004904	putative dimerization interface [polypeptide binding]; other site
565040004905	putative ligand binding site [chemical binding]; other site
565040004906	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
565040004907	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
565040004908	dimer interface [polypeptide binding]; other site
565040004909	active site
565040004910	metal binding site [ion binding]; metal-binding site
565040004911	xylose isomerase; Provisional; Region: PRK05474
565040004912	xylose isomerase; Region: xylose_isom_A; TIGR02630
565040004913	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
565040004914	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
565040004915	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
565040004916	active site
565040004917	catalytic residues [active]
565040004918	metal binding site [ion binding]; metal-binding site
565040004919	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040004920	Transcriptional regulators [Transcription]; Region: MarR; COG1846
565040004921	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
565040004922	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
565040004923	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
565040004924	TM-ABC transporter signature motif; other site
565040004925	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
565040004926	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
565040004927	Walker A/P-loop; other site
565040004928	ATP binding site [chemical binding]; other site
565040004929	Q-loop/lid; other site
565040004930	ABC transporter signature motif; other site
565040004931	Walker B; other site
565040004932	D-loop; other site
565040004933	H-loop/switch region; other site
565040004934	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
565040004935	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
565040004936	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
565040004937	putative ligand binding site [chemical binding]; other site
565040004938	MarR family; Region: MarR_2; pfam12802
565040004939	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
565040004940	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
565040004941	nucleotide binding site [chemical binding]; other site
565040004942	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
565040004943	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
565040004944	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
565040004945	Walker A/P-loop; other site
565040004946	ATP binding site [chemical binding]; other site
565040004947	Q-loop/lid; other site
565040004948	ABC transporter signature motif; other site
565040004949	Walker B; other site
565040004950	D-loop; other site
565040004951	H-loop/switch region; other site
565040004952	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
565040004953	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
565040004954	nucleotide binding site [chemical binding]; other site
565040004955	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
565040004956	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040004957	Walker A/P-loop; other site
565040004958	ATP binding site [chemical binding]; other site
565040004959	Q-loop/lid; other site
565040004960	ABC transporter signature motif; other site
565040004961	Walker B; other site
565040004962	D-loop; other site
565040004963	H-loop/switch region; other site
565040004964	ABC transporter; Region: ABC_tran_2; pfam12848
565040004965	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
565040004966	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
565040004967	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
565040004968	active site
565040004969	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
565040004970	catalytic triad [active]
565040004971	dimer interface [polypeptide binding]; other site
565040004972	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
565040004973	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
565040004974	homooctamer interface [polypeptide binding]; other site
565040004975	active site
565040004976	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
565040004977	catalytic center binding site [active]
565040004978	ATP binding site [chemical binding]; other site
565040004979	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
565040004980	catalytic center binding site [active]
565040004981	ATP binding site [chemical binding]; other site
565040004982	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
565040004983	dihydropteroate synthase; Region: DHPS; TIGR01496
565040004984	substrate binding pocket [chemical binding]; other site
565040004985	dimer interface [polypeptide binding]; other site
565040004986	inhibitor binding site; inhibition site
565040004987	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
565040004988	GTP cyclohydrolase I; Provisional; Region: PLN03044
565040004989	active site
565040004990	Preprotein translocase subunit; Region: YajC; cl00806
565040004991	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
565040004992	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040004993	Walker A motif; other site
565040004994	ATP binding site [chemical binding]; other site
565040004995	Walker B motif; other site
565040004996	arginine finger; other site
565040004997	Peptidase family M41; Region: Peptidase_M41; pfam01434
565040004998	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
565040004999	active site
565040005000	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
565040005001	Ligand Binding Site [chemical binding]; other site
565040005002	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
565040005003	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
565040005004	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
565040005005	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
565040005006	Walker A/P-loop; other site
565040005007	ATP binding site [chemical binding]; other site
565040005008	Q-loop/lid; other site
565040005009	ABC transporter signature motif; other site
565040005010	Walker B; other site
565040005011	D-loop; other site
565040005012	H-loop/switch region; other site
565040005013	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
565040005014	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
565040005015	DXD motif; other site
565040005016	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
565040005017	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
565040005018	Domain of unknown function DUF20; Region: UPF0118; pfam01594
565040005019	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
565040005020	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
565040005021	active site
565040005022	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
565040005023	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
565040005024	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
565040005025	dimer interface [polypeptide binding]; other site
565040005026	active site
565040005027	metal binding site [ion binding]; metal-binding site
565040005028	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
565040005029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
565040005030	S-adenosylmethionine binding site [chemical binding]; other site
565040005031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040005032	Major Facilitator Superfamily; Region: MFS_1; pfam07690
565040005033	putative substrate translocation pore; other site
565040005034	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
565040005035	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
565040005036	NAD(P) binding site [chemical binding]; other site
565040005037	active site
565040005038	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
565040005039	AzlC protein; Region: AzlC; cl00570
565040005040	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
565040005041	Low molecular weight phosphatase family; Region: LMWPc; cd00115
565040005042	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
565040005043	active site
565040005044	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
565040005045	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
565040005046	folate binding site [chemical binding]; other site
565040005047	NADP+ binding site [chemical binding]; other site
565040005048	thymidylate synthase; Reviewed; Region: thyA; PRK01827
565040005049	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
565040005050	dimerization interface [polypeptide binding]; other site
565040005051	active site
565040005052	OsmC-like protein; Region: OsmC; pfam02566
565040005053	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
565040005054	Ligand Binding Site [chemical binding]; other site
565040005055	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
565040005056	Ligand Binding Site [chemical binding]; other site
565040005057	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
565040005058	NlpC/P60 family; Region: NLPC_P60; pfam00877
565040005059	potential frameshift: common BLAST hit: gi|312133951|ref|YP_004001290.1| spr1
565040005060	NlpC/P60 family; Region: NLPC_P60; cl17555
565040005061	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
565040005062	CHAP domain; Region: CHAP; pfam05257
565040005063	phosphoserine aminotransferase; Provisional; Region: PRK03080
565040005064	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
565040005065	catalytic residue [active]
565040005066	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
565040005067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
565040005068	ATP binding site [chemical binding]; other site
565040005069	Mg2+ binding site [ion binding]; other site
565040005070	G-X-G motif; other site
565040005071	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
565040005072	PhoU domain; Region: PhoU; pfam01895
565040005073	PhoU domain; Region: PhoU; pfam01895
565040005074	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
565040005075	catalytic core [active]
565040005076	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
565040005077	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
565040005078	UbiA prenyltransferase family; Region: UbiA; pfam01040
565040005079	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
565040005080	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
565040005081	dimer interface [polypeptide binding]; other site
565040005082	putative anticodon binding site; other site
565040005083	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
565040005084	motif 1; other site
565040005085	dimer interface [polypeptide binding]; other site
565040005086	active site
565040005087	motif 2; other site
565040005088	motif 3; other site
565040005089	MFS transport protein AraJ; Provisional; Region: PRK10091
565040005090	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040005091	putative substrate translocation pore; other site
565040005092	Tetratricopeptide repeat; Region: TPR_12; pfam13424
565040005093	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
565040005094	binding surface
565040005095	TPR motif; other site
565040005096	Tetratricopeptide repeat; Region: TPR_12; pfam13424
565040005097	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
565040005098	Protein of unknown function (DUF4125); Region: DUF4125; pfam13526
565040005099	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
565040005100	PspC domain; Region: PspC; pfam04024
565040005101	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
565040005102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
565040005103	ATP binding site [chemical binding]; other site
565040005104	Mg2+ binding site [ion binding]; other site
565040005105	G-X-G motif; other site
565040005106	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
565040005107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
565040005108	active site
565040005109	phosphorylation site [posttranslational modification]
565040005110	intermolecular recognition site; other site
565040005111	dimerization interface [polypeptide binding]; other site
565040005112	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
565040005113	DNA binding residues [nucleotide binding]
565040005114	dimerization interface [polypeptide binding]; other site
565040005115	UDP-glucose 4-epimerase; Region: PLN02240
565040005116	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
565040005117	NAD binding site [chemical binding]; other site
565040005118	homodimer interface [polypeptide binding]; other site
565040005119	active site
565040005120	substrate binding site [chemical binding]; other site
565040005121	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
565040005122	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
565040005123	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
565040005124	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
565040005125	Phosphotransferase enzyme family; Region: APH; pfam01636
565040005126	active site
565040005127	substrate binding site [chemical binding]; other site
565040005128	ATP binding site [chemical binding]; other site
565040005129	1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336
565040005130	Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508
565040005131	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
565040005132	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040005133	dimer interface [polypeptide binding]; other site
565040005134	conserved gate region; other site
565040005135	putative PBP binding loops; other site
565040005136	ABC-ATPase subunit interface; other site
565040005137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040005138	dimer interface [polypeptide binding]; other site
565040005139	conserved gate region; other site
565040005140	ABC-ATPase subunit interface; other site
565040005141	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
565040005142	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
565040005143	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040005144	Helix-turn-helix domain; Region: HTH_38; pfam13936
565040005145	Integrase core domain; Region: rve; pfam00665
565040005146	seryl-tRNA synthetase; Provisional; Region: PRK05431
565040005147	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
565040005148	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
565040005149	dimer interface [polypeptide binding]; other site
565040005150	active site
565040005151	motif 1; other site
565040005152	motif 2; other site
565040005153	motif 3; other site
565040005154	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
565040005155	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
565040005156	transcriptional antiterminator BglG; Provisional; Region: PRK09772
565040005157	CAT RNA binding domain; Region: CAT_RBD; smart01061
565040005158	PRD domain; Region: PRD; pfam00874
565040005159	PRD domain; Region: PRD; pfam00874
565040005160	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
565040005161	active site turn [active]
565040005162	phosphorylation site [posttranslational modification]
565040005163	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
565040005164	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
565040005165	HPr interaction site; other site
565040005166	glycerol kinase (GK) interaction site [polypeptide binding]; other site
565040005167	active site
565040005168	phosphorylation site [posttranslational modification]
565040005169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040005170	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
565040005171	putative substrate translocation pore; other site
565040005172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040005173	phosphoglucomutase; Validated; Region: PRK07564
565040005174	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
565040005175	active site
565040005176	substrate binding site [chemical binding]; other site
565040005177	metal binding site [ion binding]; metal-binding site
565040005178	Transcriptional regulator; Region: Rrf2; pfam02082
565040005179	Rrf2 family protein; Region: rrf2_super; TIGR00738
565040005180	dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912
565040005181	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
565040005182	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
565040005183	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
565040005184	RNA/DNA hybrid binding site [nucleotide binding]; other site
565040005185	active site
565040005186	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
565040005187	tetramer (dimer of dimers) interface [polypeptide binding]; other site
565040005188	active site
565040005189	dimer interface [polypeptide binding]; other site
565040005190	DNA repair protein RadA; Provisional; Region: PRK11823
565040005191	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
565040005192	Walker A motif; other site
565040005193	ATP binding site [chemical binding]; other site
565040005194	Walker B motif; other site
565040005195	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
565040005196	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
565040005197	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
565040005198	active site
565040005199	Riboflavin kinase; Region: Flavokinase; pfam01687
565040005200	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
565040005201	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
565040005202	RNA binding site [nucleotide binding]; other site
565040005203	active site
565040005204	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
565040005205	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
565040005206	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
565040005207	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
565040005208	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
565040005209	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
565040005210	G1 box; other site
565040005211	putative GEF interaction site [polypeptide binding]; other site
565040005212	GTP/Mg2+ binding site [chemical binding]; other site
565040005213	Switch I region; other site
565040005214	G2 box; other site
565040005215	G3 box; other site
565040005216	Switch II region; other site
565040005217	G4 box; other site
565040005218	G5 box; other site
565040005219	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
565040005220	Translation-initiation factor 2; Region: IF-2; pfam11987
565040005221	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
565040005222	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
565040005223	NusA N-terminal domain; Region: NusA_N; pfam08529
565040005224	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
565040005225	RNA binding site [nucleotide binding]; other site
565040005226	homodimer interface [polypeptide binding]; other site
565040005227	NusA-like KH domain; Region: KH_5; pfam13184
565040005228	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
565040005229	G-X-X-G motif; other site
565040005230	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040005231	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040005232	DNA binding site [nucleotide binding]
565040005233	domain linker motif; other site
565040005234	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040005235	dimerization interface [polypeptide binding]; other site
565040005236	ligand binding site [chemical binding]; other site
565040005237	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
565040005238	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
565040005239	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
565040005240	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
565040005241	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
565040005242	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
565040005243	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
565040005244	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
565040005245	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
565040005246	dimerization interface 3.5A [polypeptide binding]; other site
565040005247	active site
565040005248	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
565040005249	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
565040005250	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
565040005251	alphaNTD homodimer interface [polypeptide binding]; other site
565040005252	alphaNTD - beta interaction site [polypeptide binding]; other site
565040005253	alphaNTD - beta' interaction site [polypeptide binding]; other site
565040005254	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
565040005255	30S ribosomal protein S11; Validated; Region: PRK05309
565040005256	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
565040005257	30S ribosomal protein S13; Region: bact_S13; TIGR03631
565040005258	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
565040005259	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
565040005260	rRNA binding site [nucleotide binding]; other site
565040005261	predicted 30S ribosome binding site; other site
565040005262	adenylate kinase; Reviewed; Region: adk; PRK00279
565040005263	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
565040005264	AMP-binding site [chemical binding]; other site
565040005265	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
565040005266	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
565040005267	SecY translocase; Region: SecY; pfam00344
565040005268	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
565040005269	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
565040005270	23S rRNA binding site [nucleotide binding]; other site
565040005271	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
565040005272	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
565040005273	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
565040005274	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
565040005275	23S rRNA interface [nucleotide binding]; other site
565040005276	L21e interface [polypeptide binding]; other site
565040005277	5S rRNA interface [nucleotide binding]; other site
565040005278	L27 interface [polypeptide binding]; other site
565040005279	L5 interface [polypeptide binding]; other site
565040005280	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
565040005281	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
565040005282	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
565040005283	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
565040005284	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
565040005285	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
565040005286	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
565040005287	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
565040005288	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
565040005289	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
565040005290	RNA binding site [nucleotide binding]; other site
565040005291	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
565040005292	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
565040005293	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
565040005294	23S rRNA interface [nucleotide binding]; other site
565040005295	putative translocon interaction site; other site
565040005296	signal recognition particle (SRP54) interaction site; other site
565040005297	L23 interface [polypeptide binding]; other site
565040005298	trigger factor interaction site; other site
565040005299	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
565040005300	23S rRNA interface [nucleotide binding]; other site
565040005301	5S rRNA interface [nucleotide binding]; other site
565040005302	putative antibiotic binding site [chemical binding]; other site
565040005303	L25 interface [polypeptide binding]; other site
565040005304	L27 interface [polypeptide binding]; other site
565040005305	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
565040005306	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
565040005307	G-X-X-G motif; other site
565040005308	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
565040005309	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
565040005310	putative translocon binding site; other site
565040005311	protein-rRNA interface [nucleotide binding]; other site
565040005312	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
565040005313	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
565040005314	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
565040005315	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
565040005316	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
565040005317	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
565040005318	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
565040005319	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
565040005320	YwiC-like protein; Region: YwiC; pfam14256
565040005321	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
565040005322	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
565040005323	putative catalytic cysteine [active]
565040005324	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
565040005325	putative active site [active]
565040005326	metal binding site [ion binding]; metal-binding site
565040005327	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
565040005328	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
565040005329	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
565040005330	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
565040005331	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
565040005332	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
565040005333	active site
565040005334	catalytic site [active]
565040005335	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
565040005336	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
565040005337	23S rRNA interface [nucleotide binding]; other site
565040005338	L3 interface [polypeptide binding]; other site
565040005339	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
565040005340	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
565040005341	Uncharacterized conserved protein [Function unknown]; Region: COG1739
565040005342	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
565040005343	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
565040005344	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
565040005345	dimerization interface [polypeptide binding]; other site
565040005346	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
565040005347	NAD binding site [chemical binding]; other site
565040005348	ligand binding site [chemical binding]; other site
565040005349	catalytic site [active]
565040005350	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
565040005351	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
565040005352	putative active site [active]
565040005353	putative metal binding site [ion binding]; other site
565040005354	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
565040005355	DNA polymerase IV; Validated; Region: PRK03858
565040005356	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
565040005357	active site
565040005358	DNA binding site [nucleotide binding]
565040005359	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
565040005360	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
565040005361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040005362	homodimer interface [polypeptide binding]; other site
565040005363	catalytic residue [active]
565040005364	Ferredoxin [Energy production and conversion]; Region: COG1146
565040005365	4Fe-4S binding domain; Region: Fer4; pfam00037
565040005366	amino acid transporter; Region: 2A0306; TIGR00909
565040005367	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
565040005368	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
565040005369	FAD binding domain; Region: FAD_binding_4; pfam01565
565040005370	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
565040005371	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
565040005372	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
565040005373	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
565040005374	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
565040005375	oligomerisation interface [polypeptide binding]; other site
565040005376	mobile loop; other site
565040005377	roof hairpin; other site
565040005378	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
565040005379	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
565040005380	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
565040005381	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
565040005382	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
565040005383	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
565040005384	Part of AAA domain; Region: AAA_19; pfam13245
565040005385	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
565040005386	phosphopeptide binding site; other site
565040005387	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
565040005388	peripheral dimer interface [polypeptide binding]; other site
565040005389	core dimer interface [polypeptide binding]; other site
565040005390	L10 interface [polypeptide binding]; other site
565040005391	L11 interface [polypeptide binding]; other site
565040005392	putative EF-Tu interaction site [polypeptide binding]; other site
565040005393	putative EF-G interaction site [polypeptide binding]; other site
565040005394	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
565040005395	23S rRNA interface [nucleotide binding]; other site
565040005396	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
565040005397	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
565040005398	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
565040005399	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
565040005400	oligomer interface [polypeptide binding]; other site
565040005401	RNA binding site [nucleotide binding]; other site
565040005402	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
565040005403	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
565040005404	RNase E interface [polypeptide binding]; other site
565040005405	trimer interface [polypeptide binding]; other site
565040005406	active site
565040005407	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
565040005408	putative nucleic acid binding region [nucleotide binding]; other site
565040005409	G-X-X-G motif; other site
565040005410	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
565040005411	RNA binding site [nucleotide binding]; other site
565040005412	domain interface; other site
565040005413	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
565040005414	16S/18S rRNA binding site [nucleotide binding]; other site
565040005415	S13e-L30e interaction site [polypeptide binding]; other site
565040005416	25S rRNA binding site [nucleotide binding]; other site
565040005417	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
565040005418	active site
565040005419	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
565040005420	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
565040005421	Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003
565040005422	substrate binding site [chemical binding]; other site
565040005423	active site
565040005424	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
565040005425	ligand binding site [chemical binding]; other site
565040005426	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
565040005427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040005428	Walker A motif; other site
565040005429	ATP binding site [chemical binding]; other site
565040005430	Walker B motif; other site
565040005431	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
565040005432	Integrase core domain; Region: rve; pfam00665
565040005433	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040005434	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
565040005435	Walker A motif; other site
565040005436	ATP binding site [chemical binding]; other site
565040005437	Walker B motif; other site
565040005438	arginine finger; other site
565040005439	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
565040005440	Integrase core domain; Region: rve; pfam00665
565040005441	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
565040005442	metal ion-dependent adhesion site (MIDAS); other site
565040005443	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
565040005444	domain interaction interfaces [polypeptide binding]; other site
565040005445	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
565040005446	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
565040005447	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
565040005448	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
565040005449	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
565040005450	phosphate binding site [ion binding]; other site
565040005451	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
565040005452	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
565040005453	putative active site [active]
565040005454	putative catalytic site [active]
565040005455	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
565040005456	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
565040005457	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
565040005458	putative NAD(P) binding site [chemical binding]; other site
565040005459	active site
565040005460	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
565040005461	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
565040005462	active site
565040005463	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
565040005464	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
565040005465	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
565040005466	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
565040005467	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
565040005468	ATP-grasp domain; Region: ATP-grasp_4; cl17255
565040005469	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
565040005470	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
565040005471	carboxyltransferase (CT) interaction site; other site
565040005472	biotinylation site [posttranslational modification]; other site
565040005473	BioY family; Region: BioY; pfam02632
565040005474	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
565040005475	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
565040005476	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
565040005477	Transcriptional regulator [Transcription]; Region: IclR; COG1414
565040005478	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
565040005479	Bacterial transcriptional regulator; Region: IclR; pfam01614
565040005480	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
565040005481	Transcriptional regulator [Transcription]; Region: IclR; COG1414
565040005482	Bacterial transcriptional regulator; Region: IclR; pfam01614
565040005483	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
565040005484	Integrase core domain; Region: rve; pfam00665
565040005485	transposase/IS protein; Provisional; Region: PRK09183
565040005486	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040005487	Walker A motif; other site
565040005488	ATP binding site [chemical binding]; other site
565040005489	Walker B motif; other site
565040005490	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
565040005491	mRNA/rRNA interface [nucleotide binding]; other site
565040005492	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
565040005493	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
565040005494	23S rRNA interface [nucleotide binding]; other site
565040005495	L7/L12 interface [polypeptide binding]; other site
565040005496	putative thiostrepton binding site; other site
565040005497	L25 interface [polypeptide binding]; other site
565040005498	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
565040005499	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
565040005500	putative homodimer interface [polypeptide binding]; other site
565040005501	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
565040005502	heterodimer interface [polypeptide binding]; other site
565040005503	homodimer interface [polypeptide binding]; other site
565040005504	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
565040005505	aspartate aminotransferase; Provisional; Region: PRK05764
565040005506	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
565040005507	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040005508	homodimer interface [polypeptide binding]; other site
565040005509	catalytic residue [active]
565040005510	gamma-glutamyl kinase; Provisional; Region: PRK05429
565040005511	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
565040005512	nucleotide binding site [chemical binding]; other site
565040005513	homotetrameric interface [polypeptide binding]; other site
565040005514	putative phosphate binding site [ion binding]; other site
565040005515	putative allosteric binding site; other site
565040005516	PUA domain; Region: PUA; pfam01472
565040005517	GTPase CgtA; Reviewed; Region: obgE; PRK12296
565040005518	GTP1/OBG; Region: GTP1_OBG; pfam01018
565040005519	Obg GTPase; Region: Obg; cd01898
565040005520	G1 box; other site
565040005521	GTP/Mg2+ binding site [chemical binding]; other site
565040005522	Switch I region; other site
565040005523	G2 box; other site
565040005524	G3 box; other site
565040005525	Switch II region; other site
565040005526	G4 box; other site
565040005527	G5 box; other site
565040005528	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
565040005529	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
565040005530	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
565040005531	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
565040005532	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
565040005533	homodimer interface [polypeptide binding]; other site
565040005534	oligonucleotide binding site [chemical binding]; other site
565040005535	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
565040005536	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
565040005537	metal binding site [ion binding]; metal-binding site
565040005538	putative dimer interface [polypeptide binding]; other site
565040005539	Predicted permeases [General function prediction only]; Region: COG0679
565040005540	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
565040005541	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
565040005542	Walker A/P-loop; other site
565040005543	ATP binding site [chemical binding]; other site
565040005544	Q-loop/lid; other site
565040005545	ABC transporter signature motif; other site
565040005546	Walker B; other site
565040005547	D-loop; other site
565040005548	H-loop/switch region; other site
565040005549	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
565040005550	putative active site [active]
565040005551	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
565040005552	dimer interface [polypeptide binding]; other site
565040005553	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
565040005554	nudix motif; other site
565040005555	homoserine kinase; Provisional; Region: PRK01212
565040005556	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
565040005557	homoserine dehydrogenase; Provisional; Region: PRK06349
565040005558	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
565040005559	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
565040005560	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
565040005561	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
565040005562	catalytic residue [active]
565040005563	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
565040005564	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
565040005565	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
565040005566	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
565040005567	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
565040005568	active site
565040005569	HIGH motif; other site
565040005570	nucleotide binding site [chemical binding]; other site
565040005571	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
565040005572	KMSK motif region; other site
565040005573	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
565040005574	tRNA binding surface [nucleotide binding]; other site
565040005575	anticodon binding site; other site
565040005576	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
565040005577	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
565040005578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040005579	Major Facilitator Superfamily; Region: MFS_1; pfam07690
565040005580	putative substrate translocation pore; other site
565040005581	Transcriptional regulator [Transcription]; Region: LysR; COG0583
565040005582	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
565040005583	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
565040005584	putative dimerization interface [polypeptide binding]; other site
565040005585	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
565040005586	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
565040005587	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040005588	homodimer interface [polypeptide binding]; other site
565040005589	catalytic residue [active]
565040005590	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
565040005591	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
565040005592	hinge; other site
565040005593	active site
565040005594	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
565040005595	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
565040005596	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
565040005597	Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810
565040005598	active site
565040005599	FMN binding site [chemical binding]; other site
565040005600	substrate binding site [chemical binding]; other site
565040005601	CAAX protease self-immunity; Region: Abi; pfam02517
565040005602	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
565040005603	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
565040005604	substrate binding site [chemical binding]; other site
565040005605	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
565040005606	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
565040005607	substrate binding site [chemical binding]; other site
565040005608	ligand binding site [chemical binding]; other site
565040005609	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
565040005610	Transcriptional regulator [Transcription]; Region: IclR; COG1414
565040005611	Bacterial transcriptional regulator; Region: IclR; pfam01614
565040005612	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
565040005613	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
565040005614	putative active site [active]
565040005615	putative metal binding site [ion binding]; other site
565040005616	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
565040005617	polyphosphate kinase; Provisional; Region: PRK05443
565040005618	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
565040005619	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
565040005620	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
565040005621	putative domain interface [polypeptide binding]; other site
565040005622	putative active site [active]
565040005623	catalytic site [active]
565040005624	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
565040005625	putative domain interface [polypeptide binding]; other site
565040005626	putative active site [active]
565040005627	catalytic site [active]
565040005628	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
565040005629	active site
565040005630	Ap6A binding site [chemical binding]; other site
565040005631	nudix motif; other site
565040005632	metal binding site [ion binding]; metal-binding site
565040005633	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
565040005634	catalytic core [active]
565040005635	AAA domain; Region: AAA_14; pfam13173
565040005636	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
565040005637	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
565040005638	active site
565040005639	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
565040005640	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
565040005641	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
565040005642	active site
565040005643	catalytic site [active]
565040005644	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
565040005645	active site
565040005646	HIGH motif; other site
565040005647	nucleotide binding site [chemical binding]; other site
565040005648	active site
565040005649	KMSKS motif; other site
565040005650	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
565040005651	Clp amino terminal domain; Region: Clp_N; pfam02861
565040005652	Clp amino terminal domain; Region: Clp_N; pfam02861
565040005653	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040005654	Walker A motif; other site
565040005655	ATP binding site [chemical binding]; other site
565040005656	Walker B motif; other site
565040005657	arginine finger; other site
565040005658	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040005659	Walker A motif; other site
565040005660	ATP binding site [chemical binding]; other site
565040005661	Walker B motif; other site
565040005662	arginine finger; other site
565040005663	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
565040005664	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
565040005665	active sites [active]
565040005666	tetramer interface [polypeptide binding]; other site
565040005667	Transcriptional regulator [Transcription]; Region: IclR; COG1414
565040005668	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
565040005669	Bacterial transcriptional regulator; Region: IclR; pfam01614
565040005670	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
565040005671	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
565040005672	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
565040005673	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
565040005674	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
565040005675	UDP-galactopyranose mutase; Region: GLF; pfam03275
565040005676	putative glycosyl transferase; Provisional; Region: PRK10073
565040005677	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
565040005678	active site
565040005679	Sulfatase; Region: Sulfatase; pfam00884
565040005680	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
565040005681	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
565040005682	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
565040005683	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
565040005684	Walker A/P-loop; other site
565040005685	ATP binding site [chemical binding]; other site
565040005686	Q-loop/lid; other site
565040005687	ABC transporter signature motif; other site
565040005688	Walker B; other site
565040005689	D-loop; other site
565040005690	H-loop/switch region; other site
565040005691	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
565040005692	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
565040005693	Rhamnan synthesis protein F; Region: RgpF; pfam05045
565040005694	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
565040005695	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
565040005696	active site
565040005697	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
565040005698	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
565040005699	substrate binding site; other site
565040005700	tetramer interface; other site
565040005701	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
565040005702	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
565040005703	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
565040005704	NADP binding site [chemical binding]; other site
565040005705	active site
565040005706	putative substrate binding site [chemical binding]; other site
565040005707	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
565040005708	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
565040005709	NAD binding site [chemical binding]; other site
565040005710	substrate binding site [chemical binding]; other site
565040005711	homodimer interface [polypeptide binding]; other site
565040005712	active site
565040005713	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
565040005714	Ligand binding site; other site
565040005715	Putative Catalytic site; other site
565040005716	DXD motif; other site
565040005717	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
565040005718	Acyltransferase family; Region: Acyl_transf_3; pfam01757
565040005719	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
565040005720	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
565040005721	FtsX-like permease family; Region: FtsX; pfam02687
565040005722	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040005723	ABC transporter; Region: ABC_tran; pfam00005
565040005724	Q-loop/lid; other site
565040005725	ABC transporter signature motif; other site
565040005726	Walker B; other site
565040005727	D-loop; other site
565040005728	H-loop/switch region; other site
565040005729	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
565040005730	Zn2+ binding site [ion binding]; other site
565040005731	Mg2+ binding site [ion binding]; other site
565040005732	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
565040005733	putative active site [active]
565040005734	putative dimer interface [polypeptide binding]; other site
565040005735	K+ potassium transporter; Region: K_trans; pfam02705
565040005736	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
565040005737	active site
565040005738	Fic family protein [Function unknown]; Region: COG3177
565040005739	Fic/DOC family; Region: Fic; pfam02661
565040005740	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
565040005741	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
565040005742	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
565040005743	Walker A/P-loop; other site
565040005744	ATP binding site [chemical binding]; other site
565040005745	Q-loop/lid; other site
565040005746	ABC transporter signature motif; other site
565040005747	Walker B; other site
565040005748	D-loop; other site
565040005749	H-loop/switch region; other site
565040005750	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
565040005751	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
565040005752	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040005753	Walker A/P-loop; other site
565040005754	ATP binding site [chemical binding]; other site
565040005755	Q-loop/lid; other site
565040005756	ABC transporter signature motif; other site
565040005757	Walker B; other site
565040005758	D-loop; other site
565040005759	H-loop/switch region; other site
565040005760	alpha-galactosidase; Region: PLN02808; cl17638
565040005761	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040005762	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040005763	DNA binding site [nucleotide binding]
565040005764	domain linker motif; other site
565040005765	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040005766	dimerization interface [polypeptide binding]; other site
565040005767	ligand binding site [chemical binding]; other site
565040005768	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
565040005769	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
565040005770	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
565040005771	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
565040005772	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
565040005773	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
565040005774	trimer interface [polypeptide binding]; other site
565040005775	active site
565040005776	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
565040005777	active site
565040005778	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
565040005779	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
565040005780	active site
565040005781	HIGH motif; other site
565040005782	KMSKS motif; other site
565040005783	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
565040005784	tRNA binding surface [nucleotide binding]; other site
565040005785	anticodon binding site; other site
565040005786	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
565040005787	Predicted methyltransferases [General function prediction only]; Region: COG0313
565040005788	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
565040005789	putative SAM binding site [chemical binding]; other site
565040005790	putative homodimer interface [polypeptide binding]; other site
565040005791	MFS/sugar transport protein; Region: MFS_2; pfam13347
565040005792	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
565040005793	ApbE family; Region: ApbE; pfam02424
565040005794	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
565040005795	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
565040005796	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
565040005797	Walker A/P-loop; other site
565040005798	ATP binding site [chemical binding]; other site
565040005799	Q-loop/lid; other site
565040005800	ABC transporter signature motif; other site
565040005801	Walker B; other site
565040005802	D-loop; other site
565040005803	H-loop/switch region; other site
565040005804	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
565040005805	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
565040005806	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
565040005807	Walker A/P-loop; other site
565040005808	ATP binding site [chemical binding]; other site
565040005809	Q-loop/lid; other site
565040005810	ABC transporter signature motif; other site
565040005811	Walker B; other site
565040005812	D-loop; other site
565040005813	H-loop/switch region; other site
565040005814	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
565040005815	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
565040005816	active site
565040005817	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
565040005818	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
565040005819	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
565040005820	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
565040005821	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
565040005822	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
565040005823	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
565040005824	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
565040005825	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
565040005826	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
565040005827	Divergent AAA domain; Region: AAA_4; pfam04326
565040005828	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
565040005829	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
565040005830	Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795
565040005831	FtsX-like permease family; Region: FtsX; pfam02687
565040005832	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
565040005833	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
565040005834	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
565040005835	Walker A/P-loop; other site
565040005836	ATP binding site [chemical binding]; other site
565040005837	Q-loop/lid; other site
565040005838	ABC transporter signature motif; other site
565040005839	Walker B; other site
565040005840	D-loop; other site
565040005841	H-loop/switch region; other site
565040005842	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
565040005843	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
565040005844	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
565040005845	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
565040005846	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
565040005847	AAA domain; Region: AAA_14; pfam13173
565040005848	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
565040005849	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
565040005850	Transposase; Region: DDE_Tnp_ISL3; pfam01610
565040005851	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
565040005852	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
565040005853	Transposase; Region: DDE_Tnp_ISL3; pfam01610
565040005854	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
565040005855	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
565040005856	Glycosyl hydrolase family 43; Region: GH43_4; cd08983
565040005857	active site
565040005858	Protein of unknown function, DUF624; Region: DUF624; pfam04854
565040005859	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
565040005860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040005861	dimer interface [polypeptide binding]; other site
565040005862	conserved gate region; other site
565040005863	putative PBP binding loops; other site
565040005864	ABC-ATPase subunit interface; other site
565040005865	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
565040005866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040005867	putative PBP binding loops; other site
565040005868	dimer interface [polypeptide binding]; other site
565040005869	ABC-ATPase subunit interface; other site
565040005870	Transcriptional regulators [Transcription]; Region: PurR; COG1609
565040005871	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
565040005872	DNA binding site [nucleotide binding]
565040005873	domain linker motif; other site
565040005874	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
565040005875	ligand binding site [chemical binding]; other site
565040005876	dimerization interface [polypeptide binding]; other site
565040005877	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
565040005878	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
565040005879	catalytic core [active]
565040005880	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
565040005881	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
565040005882	dimer interface [polypeptide binding]; other site
565040005883	FMN binding site [chemical binding]; other site
565040005884	NADPH bind site [chemical binding]; other site
565040005885	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
565040005886	Predicted membrane protein [Function unknown]; Region: COG1511
565040005887	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
565040005888	Predicted membrane protein [Function unknown]; Region: COG1511
565040005889	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
565040005890	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
565040005891	putative transposase OrfB; Reviewed; Region: PHA02517
565040005892	HTH-like domain; Region: HTH_21; pfam13276
565040005893	Integrase core domain; Region: rve; pfam00665
565040005894	Integrase core domain; Region: rve_2; pfam13333
565040005895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040005896	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
565040005897	Walker A motif; other site
565040005898	ATP binding site [chemical binding]; other site
565040005899	Walker B motif; other site
565040005900	arginine finger; other site
565040005901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
565040005902	Integrase core domain; Region: rve; pfam00665
565040005903	NAD-dependent deacetylase; Provisional; Region: PRK00481
565040005904	SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent...; Region: SIRT7; cd01410
565040005905	NAD+ binding site [chemical binding]; other site
565040005906	substrate binding site [chemical binding]; other site
565040005907	Zn binding site [ion binding]; other site
565040005908	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
565040005909	tetramer interface [polypeptide binding]; other site
565040005910	threonine dehydratase; Provisional; Region: PRK08198
565040005911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
565040005912	catalytic residue [active]
565040005913	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
565040005914	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
565040005915	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
565040005916	Ca binding site [ion binding]; other site
565040005917	active site
565040005918	catalytic site [active]
565040005919	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
565040005920	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040005921	dimer interface [polypeptide binding]; other site
565040005922	conserved gate region; other site
565040005923	putative PBP binding loops; other site
565040005924	ABC-ATPase subunit interface; other site
565040005925	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
565040005926	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040005927	dimer interface [polypeptide binding]; other site
565040005928	conserved gate region; other site
565040005929	putative PBP binding loops; other site
565040005930	ABC-ATPase subunit interface; other site
565040005931	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
565040005932	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
565040005933	MarR family; Region: MarR_2; pfam12802
565040005934	Transcriptional regulators [Transcription]; Region: MarR; COG1846
565040005935	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
565040005936	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
565040005937	Melibiase; Region: Melibiase; pfam02065
565040005938	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
565040005939	nucleoside/Zn binding site; other site
565040005940	dimer interface [polypeptide binding]; other site
565040005941	catalytic motif [active]
565040005942	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
565040005943	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
565040005944	Serine hydrolase (FSH1); Region: FSH1; pfam03959
565040005945	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
565040005946	trimer interface [polypeptide binding]; other site
565040005947	active site
565040005948	Predicted membrane protein [Function unknown]; Region: COG1511
565040005949	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
565040005950	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
565040005951	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
565040005952	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
565040005953	Soluble P-type ATPase [General function prediction only]; Region: COG4087
565040005954	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
565040005955	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
565040005956	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
565040005957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040005958	Major Facilitator Superfamily; Region: MFS_1; pfam07690
565040005959	putative substrate translocation pore; other site
565040005960	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
565040005961	putative substrate translocation pore; other site
565040005962	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
565040005963	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
565040005964	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
565040005965	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
565040005966	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
565040005967	active site
565040005968	catalytic site [active]
565040005969	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
565040005970	Cna protein B-type domain; Region: Cna_B; pfam05738
565040005971	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
565040005972	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
565040005973	Walker A/P-loop; other site
565040005974	ATP binding site [chemical binding]; other site
565040005975	Q-loop/lid; other site
565040005976	ABC transporter signature motif; other site
565040005977	Walker B; other site
565040005978	D-loop; other site
565040005979	H-loop/switch region; other site
565040005980	TOBE domain; Region: TOBE_2; pfam08402
565040005981	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
565040005982	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
565040005983	active site
565040005984	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
565040005985	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
565040005986	dimer interface [polypeptide binding]; other site
565040005987	putative radical transfer pathway; other site
565040005988	diiron center [ion binding]; other site
565040005989	tyrosyl radical; other site
565040005990	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
565040005991	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
565040005992	Class I ribonucleotide reductase; Region: RNR_I; cd01679
565040005993	active site
565040005994	dimer interface [polypeptide binding]; other site
565040005995	catalytic residues [active]
565040005996	effector binding site; other site
565040005997	R2 peptide binding site; other site
565040005998	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
565040005999	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
565040006000	catalytic residues [active]
565040006001	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
565040006002	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
565040006003	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
565040006004	GtrA-like protein; Region: GtrA; pfam04138
565040006005	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
565040006006	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
565040006007	non-specific DNA binding site [nucleotide binding]; other site
565040006008	salt bridge; other site
565040006009	sequence-specific DNA binding site [nucleotide binding]; other site
565040006010	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
565040006011	Ion channel; Region: Ion_trans_2; pfam07885
565040006012	AAA ATPase domain; Region: AAA_16; pfam13191
565040006013	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
565040006014	Catalytic domain of Protein Kinases; Region: PKc; cd00180
565040006015	active site
565040006016	ATP binding site [chemical binding]; other site
565040006017	substrate binding site [chemical binding]; other site
565040006018	activation loop (A-loop); other site
565040006019	Gamma interferon inducible lysosomal thiol reductase (GILT); Region: GILT; pfam03227
565040006020	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
565040006021	Domain of unknown function (DUF348); Region: DUF348; pfam03990
565040006022	G5 domain; Region: G5; pfam07501
565040006023	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
565040006024	N-acetyl-D-glucosamine binding site [chemical binding]; other site
565040006025	catalytic residue [active]
565040006026	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
565040006027	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
565040006028	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
565040006029	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
565040006030	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
565040006031	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
565040006032	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
565040006033	active site
565040006034	NTP binding site [chemical binding]; other site
565040006035	metal binding triad [ion binding]; metal-binding site
565040006036	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
565040006037	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
565040006038	Zn2+ binding site [ion binding]; other site
565040006039	Mg2+ binding site [ion binding]; other site
565040006040	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
565040006041	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
565040006042	active site
565040006043	Ap6A binding site [chemical binding]; other site
565040006044	nudix motif; other site
565040006045	metal binding site [ion binding]; metal-binding site
565040006046	integral membrane protein MviN; Region: mviN; TIGR01695
565040006047	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
565040006048	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
565040006049	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
565040006050	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
565040006051	putative transposase OrfB; Reviewed; Region: PHA02517
565040006052	HTH-like domain; Region: HTH_21; pfam13276
565040006053	Integrase core domain; Region: rve; pfam00665
565040006054	Integrase core domain; Region: rve_2; pfam13333
565040006055	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
565040006056	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
565040006057	Ca binding site [ion binding]; other site
565040006058	active site
565040006059	catalytic site [active]
565040006060	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
565040006061	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040006062	Walker A motif; other site
565040006063	ATP binding site [chemical binding]; other site
565040006064	Walker B motif; other site
565040006065	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
565040006066	Integrase core domain; Region: rve; pfam00665
565040006067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
565040006068	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
565040006069	Walker A motif; other site
565040006070	ATP binding site [chemical binding]; other site
565040006071	Walker B motif; other site
565040006072	arginine finger; other site
565040006073	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
565040006074	Integrase core domain; Region: rve; pfam00665
565040006075	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
565040006076	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
565040006077	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
565040006078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040006079	dimer interface [polypeptide binding]; other site
565040006080	conserved gate region; other site
565040006081	putative PBP binding loops; other site
565040006082	ABC-ATPase subunit interface; other site
565040006083	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
565040006084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
565040006085	dimer interface [polypeptide binding]; other site
565040006086	conserved gate region; other site
565040006087	putative PBP binding loops; other site
565040006088	ABC-ATPase subunit interface; other site
565040006089	Transposase, Mutator family; Region: Transposase_mut; pfam00872
565040006090	MULE transposase domain; Region: MULE; pfam10551
565040006091	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
565040006092	ParB-like nuclease domain; Region: ParBc; pfam02195
565040006093	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
565040006094	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
565040006095	P-loop; other site
565040006096	Magnesium ion binding site [ion binding]; other site
565040006097	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
565040006098	Magnesium ion binding site [ion binding]; other site
565040006099	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
565040006100	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
565040006101	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
565040006102	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
565040006103	G-X-X-G motif; other site
565040006104	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
565040006105	RxxxH motif; other site
565040006106	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
565040006107	Ribonuclease P; Region: Ribonuclease_P; pfam00825
565040006108	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
565040006109	MobA/MobL family; Region: MobA_MobL; pfam03389
565040006110	Initiator Replication protein; Region: Rep_3; pfam01051
565040006111	MobA/MobL family; Region: MobA_MobL; pfam03389
565040006112	Initiator Replication protein; Region: Rep_3; pfam01051