-- dump date   	20140619_002758
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
391904000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
391904000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904000003	Walker A motif; other site
391904000004	ATP binding site [chemical binding]; other site
391904000005	Walker B motif; other site
391904000006	arginine finger; other site
391904000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
391904000008	DnaA box-binding interface [nucleotide binding]; other site
391904000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
391904000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
391904000011	putative DNA binding surface [nucleotide binding]; other site
391904000012	dimer interface [polypeptide binding]; other site
391904000013	beta-clamp/clamp loader binding surface; other site
391904000014	beta-clamp/translesion DNA polymerase binding surface; other site
391904000015	recombination protein F; Reviewed; Region: recF; PRK00064
391904000016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904000017	Walker A/P-loop; other site
391904000018	ATP binding site [chemical binding]; other site
391904000019	Q-loop/lid; other site
391904000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904000021	ABC transporter signature motif; other site
391904000022	Walker B; other site
391904000023	D-loop; other site
391904000024	H-loop/switch region; other site
391904000025	Protein of unknown function (DUF721); Region: DUF721; pfam05258
391904000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
391904000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904000028	Mg2+ binding site [ion binding]; other site
391904000029	G-X-G motif; other site
391904000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
391904000031	anchoring element; other site
391904000032	dimer interface [polypeptide binding]; other site
391904000033	ATP binding site [chemical binding]; other site
391904000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
391904000035	active site
391904000036	putative metal-binding site [ion binding]; other site
391904000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
391904000038	DNA gyrase subunit A; Validated; Region: PRK05560
391904000039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
391904000040	CAP-like domain; other site
391904000041	active site
391904000042	primary dimer interface [polypeptide binding]; other site
391904000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904000049	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
391904000050	Archaeal ATPase; Region: Arch_ATPase; pfam01637
391904000051	AAA domain; Region: AAA_14; pfam13173
391904000052	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
391904000053	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904000054	glutamate dehydrogenase; Provisional; Region: PRK09414
391904000055	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
391904000056	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
391904000057	NAD(P) binding site [chemical binding]; other site
391904000058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
391904000059	RelB antitoxin; Region: RelB; cl01171
391904000060	selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918
391904000061	Transposase; Region: DDE_Tnp_ISL3; pfam01610
391904000062	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
391904000063	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
391904000064	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
391904000065	active site
391904000066	metal binding site [ion binding]; metal-binding site
391904000067	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
391904000068	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000069	dimer interface [polypeptide binding]; other site
391904000070	conserved gate region; other site
391904000071	putative PBP binding loops; other site
391904000072	ABC-ATPase subunit interface; other site
391904000073	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
391904000074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000075	dimer interface [polypeptide binding]; other site
391904000076	conserved gate region; other site
391904000077	ABC-ATPase subunit interface; other site
391904000078	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
391904000079	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
391904000080	Walker A/P-loop; other site
391904000081	ATP binding site [chemical binding]; other site
391904000082	Q-loop/lid; other site
391904000083	ABC transporter signature motif; other site
391904000084	Walker B; other site
391904000085	D-loop; other site
391904000086	H-loop/switch region; other site
391904000087	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
391904000088	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904000089	substrate binding pocket [chemical binding]; other site
391904000090	membrane-bound complex binding site; other site
391904000091	hinge residues; other site
391904000092	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
391904000093	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
391904000094	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
391904000095	putative active site [active]
391904000096	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
391904000097	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904000098	AAA domain; Region: AAA_14; pfam13173
391904000099	Protein of unknown function DUF45; Region: DUF45; pfam01863
391904000100	AAA domain; Region: AAA_14; pfam13173
391904000101	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904000102	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
391904000103	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
391904000104	dimerization interface [polypeptide binding]; other site
391904000105	DPS ferroxidase diiron center [ion binding]; other site
391904000106	ion pore; other site
391904000107	Domain of unknown function DUF21; Region: DUF21; pfam01595
391904000108	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
391904000109	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
391904000110	Transporter associated domain; Region: CorC_HlyC; smart01091
391904000111	AAA ATPase domain; Region: AAA_16; pfam13191
391904000112	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904000113	Walker B; other site
391904000114	D-loop; other site
391904000115	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
391904000116	active site clefts [active]
391904000117	zinc binding site [ion binding]; other site
391904000118	dimer interface [polypeptide binding]; other site
391904000119	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
391904000120	peroxiredoxin; Region: AhpC; TIGR03137
391904000121	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
391904000122	dimer interface [polypeptide binding]; other site
391904000123	decamer (pentamer of dimers) interface [polypeptide binding]; other site
391904000124	catalytic triad [active]
391904000125	peroxidatic and resolving cysteines [active]
391904000126	putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143
391904000127	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391904000128	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391904000129	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
391904000130	catalytic residue [active]
391904000131	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
391904000132	catalytic residues [active]
391904000133	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000134	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904000135	putative substrate translocation pore; other site
391904000136	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904000137	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904000138	Winged helix-turn helix; Region: HTH_29; pfam13551
391904000139	putative transposase OrfB; Reviewed; Region: PHA02517
391904000140	HTH-like domain; Region: HTH_21; pfam13276
391904000141	Integrase core domain; Region: rve; pfam00665
391904000142	Integrase core domain; Region: rve_2; pfam13333
391904000143	Transposase, Mutator family; Region: Transposase_mut; pfam00872
391904000144	MULE transposase domain; Region: MULE; pfam10551
391904000145	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
391904000146	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904000147	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904000148	DNA binding site [nucleotide binding]
391904000149	domain linker motif; other site
391904000150	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904000151	dimerization interface [polypeptide binding]; other site
391904000152	ligand binding site [chemical binding]; other site
391904000153	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904000154	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904000155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000156	dimer interface [polypeptide binding]; other site
391904000157	conserved gate region; other site
391904000158	putative PBP binding loops; other site
391904000159	ABC-ATPase subunit interface; other site
391904000160	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904000161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000162	dimer interface [polypeptide binding]; other site
391904000163	conserved gate region; other site
391904000164	putative PBP binding loops; other site
391904000165	ABC-ATPase subunit interface; other site
391904000166	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
391904000167	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
391904000168	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391904000169	Integrase core domain; Region: rve_2; pfam13333
391904000170	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904000171	AAA domain; Region: AAA_14; pfam13173
391904000172	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
391904000173	Divergent AAA domain; Region: AAA_4; pfam04326
391904000174	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
391904000175	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
391904000176	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
391904000177	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
391904000178	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904000179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000180	dimer interface [polypeptide binding]; other site
391904000181	conserved gate region; other site
391904000182	putative PBP binding loops; other site
391904000183	ABC-ATPase subunit interface; other site
391904000184	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904000185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000186	dimer interface [polypeptide binding]; other site
391904000187	conserved gate region; other site
391904000188	putative PBP binding loops; other site
391904000189	ABC-ATPase subunit interface; other site
391904000190	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
391904000191	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904000192	Walker A/P-loop; other site
391904000193	ATP binding site [chemical binding]; other site
391904000194	Q-loop/lid; other site
391904000195	ABC transporter signature motif; other site
391904000196	Walker B; other site
391904000197	D-loop; other site
391904000198	H-loop/switch region; other site
391904000199	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904000200	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904000201	Walker A/P-loop; other site
391904000202	ATP binding site [chemical binding]; other site
391904000203	Q-loop/lid; other site
391904000204	ABC transporter signature motif; other site
391904000205	Walker B; other site
391904000206	D-loop; other site
391904000207	H-loop/switch region; other site
391904000208	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
391904000209	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
391904000210	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
391904000211	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
391904000212	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
391904000213	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
391904000214	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
391904000215	Na binding site [ion binding]; other site
391904000216	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
391904000217	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
391904000218	active site
391904000219	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
391904000220	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
391904000221	active site
391904000222	HIGH motif; other site
391904000223	dimer interface [polypeptide binding]; other site
391904000224	KMSKS motif; other site
391904000225	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904000226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904000227	active site
391904000228	phosphorylation site [posttranslational modification]
391904000229	intermolecular recognition site; other site
391904000230	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904000231	DNA binding residues [nucleotide binding]
391904000232	dimerization interface [polypeptide binding]; other site
391904000233	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904000234	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904000235	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
391904000236	homodimer interface [polypeptide binding]; other site
391904000237	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
391904000238	active site pocket [active]
391904000239	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
391904000240	putative septation inhibitor protein; Reviewed; Region: PRK02251
391904000241	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
391904000242	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
391904000243	active site
391904000244	catalytic site [active]
391904000245	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
391904000246	Glutamine amidotransferase class-I; Region: GATase; pfam00117
391904000247	glutamine binding [chemical binding]; other site
391904000248	catalytic triad [active]
391904000249	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
391904000250	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
391904000251	active site
391904000252	ATP binding site [chemical binding]; other site
391904000253	substrate binding site [chemical binding]; other site
391904000254	activation loop (A-loop); other site
391904000255	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
391904000256	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
391904000257	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
391904000258	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
391904000259	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
391904000260	active site
391904000261	ATP binding site [chemical binding]; other site
391904000262	substrate binding site [chemical binding]; other site
391904000263	activation loop (A-loop); other site
391904000264	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
391904000265	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
391904000266	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
391904000267	active site
391904000268	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
391904000269	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
391904000270	phosphopeptide binding site; other site
391904000271	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
391904000272	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
391904000273	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
391904000274	phosphopeptide binding site; other site
391904000275	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
391904000276	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
391904000277	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391904000278	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
391904000279	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
391904000280	aromatic amino acid exporter; Provisional; Region: PRK11689
391904000281	Putative esterase; Region: Esterase; pfam00756
391904000282	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
391904000283	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
391904000284	methionine sulfoxide reductase B; Provisional; Region: PRK00222
391904000285	SelR domain; Region: SelR; pfam01641
391904000286	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
391904000287	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
391904000288	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
391904000289	cofactor binding site; other site
391904000290	DNA binding site [nucleotide binding]
391904000291	substrate interaction site [chemical binding]; other site
391904000292	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
391904000293	hypothetical protein; Provisional; Region: PRK01119
391904000294	Haemolysin-III related; Region: HlyIII; pfam03006
391904000295	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
391904000296	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
391904000297	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
391904000298	putative dimer interface [polypeptide binding]; other site
391904000299	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
391904000300	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
391904000301	conserved cys residue [active]
391904000302	PemK-like protein; Region: PemK; pfam02452
391904000303	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
391904000304	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
391904000305	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
391904000306	potential frameshift: common BLAST hit: gi|213691023|ref|YP_002321609.1| peptidase S1 and S6, chymotrypsin/Hap
391904000307	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
391904000308	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
391904000309	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
391904000310	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
391904000311	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
391904000312	Soluble P-type ATPase [General function prediction only]; Region: COG4087
391904000313	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
391904000314	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
391904000315	putative ligand binding site [chemical binding]; other site
391904000316	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
391904000317	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
391904000318	TM-ABC transporter signature motif; other site
391904000319	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
391904000320	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
391904000321	TM-ABC transporter signature motif; other site
391904000322	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
391904000323	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
391904000324	Walker A/P-loop; other site
391904000325	ATP binding site [chemical binding]; other site
391904000326	Q-loop/lid; other site
391904000327	ABC transporter signature motif; other site
391904000328	Walker B; other site
391904000329	D-loop; other site
391904000330	H-loop/switch region; other site
391904000331	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904000332	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
391904000333	Walker A/P-loop; other site
391904000334	ATP binding site [chemical binding]; other site
391904000335	Q-loop/lid; other site
391904000336	ABC transporter signature motif; other site
391904000337	Walker B; other site
391904000338	D-loop; other site
391904000339	H-loop/switch region; other site
391904000340	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
391904000341	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
391904000342	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
391904000343	alpha-gamma subunit interface [polypeptide binding]; other site
391904000344	beta-gamma subunit interface [polypeptide binding]; other site
391904000345	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
391904000346	gamma-beta subunit interface [polypeptide binding]; other site
391904000347	alpha-beta subunit interface [polypeptide binding]; other site
391904000348	urease subunit alpha; Reviewed; Region: ureC; PRK13207
391904000349	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
391904000350	subunit interactions [polypeptide binding]; other site
391904000351	active site
391904000352	flap region; other site
391904000353	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
391904000354	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
391904000355	dimer interface [polypeptide binding]; other site
391904000356	catalytic residues [active]
391904000357	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
391904000358	UreF; Region: UreF; pfam01730
391904000359	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
391904000360	G1 box; other site
391904000361	GTP/Mg2+ binding site [chemical binding]; other site
391904000362	G2 box; other site
391904000363	Switch I region; other site
391904000364	G3 box; other site
391904000365	Switch II region; other site
391904000366	G4 box; other site
391904000367	G5 box; other site
391904000368	UreD urease accessory protein; Region: UreD; cl00530
391904000369	ferredoxin-NADP+ reductase; Region: PLN02852
391904000370	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
391904000371	heat shock protein HtpX; Provisional; Region: PRK03072
391904000372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000373	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904000374	putative substrate translocation pore; other site
391904000375	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
391904000376	active site
391904000377	SUMO-1 interface [polypeptide binding]; other site
391904000378	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
391904000379	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
391904000380	active site
391904000381	intersubunit interface [polypeptide binding]; other site
391904000382	zinc binding site [ion binding]; other site
391904000383	Na+ binding site [ion binding]; other site
391904000384	AAA domain; Region: AAA_23; pfam13476
391904000385	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904000386	Walker A/P-loop; other site
391904000387	ATP binding site [chemical binding]; other site
391904000388	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
391904000389	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
391904000390	GDP-binding site [chemical binding]; other site
391904000391	ACT binding site; other site
391904000392	IMP binding site; other site
391904000393	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
391904000394	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
391904000395	Cl- selectivity filter; other site
391904000396	Cl- binding residues [ion binding]; other site
391904000397	pore gating glutamate residue; other site
391904000398	dimer interface [polypeptide binding]; other site
391904000399	H+/Cl- coupling transport residue; other site
391904000400	TrkA-C domain; Region: TrkA_C; pfam02080
391904000401	CrcB-like protein; Region: CRCB; pfam02537
391904000402	CrcB-like protein; Region: CRCB; pfam02537
391904000403	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904000404	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904000405	DNA binding site [nucleotide binding]
391904000406	domain linker motif; other site
391904000407	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904000408	sucrose phosphorylase; Provisional; Region: PRK13840
391904000409	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
391904000410	active site
391904000411	homodimer interface [polypeptide binding]; other site
391904000412	catalytic site [active]
391904000413	Domain of unknown function (DUF1964); Region: DUF1964; pfam09244
391904000414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000415	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000416	metabolite-proton symporter; Region: 2A0106; TIGR00883
391904000417	putative substrate translocation pore; other site
391904000418	ketol-acid reductoisomerase; Provisional; Region: PRK05479
391904000419	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
391904000420	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
391904000421	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
391904000422	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
391904000423	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904000424	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
391904000425	Walker A/P-loop; other site
391904000426	Walker A/P-loop; other site
391904000427	ATP binding site [chemical binding]; other site
391904000428	ATP binding site [chemical binding]; other site
391904000429	Q-loop/lid; other site
391904000430	ABC transporter signature motif; other site
391904000431	Walker B; other site
391904000432	D-loop; other site
391904000433	H-loop/switch region; other site
391904000434	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
391904000435	ketol-acid reductoisomerase; Provisional; Region: PRK05479
391904000436	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
391904000437	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
391904000438	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
391904000439	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
391904000440	active site
391904000441	catalytic site [active]
391904000442	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
391904000443	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904000444	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904000445	DNA binding site [nucleotide binding]
391904000446	domain linker motif; other site
391904000447	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904000448	ligand binding site [chemical binding]; other site
391904000449	dimerization interface [polypeptide binding]; other site
391904000450	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
391904000451	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
391904000452	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
391904000453	alkaline phosphatase; Provisional; Region: PRK10518
391904000454	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
391904000455	active site
391904000456	dimer interface [polypeptide binding]; other site
391904000457	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
391904000458	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904000459	nucleotide binding site [chemical binding]; other site
391904000460	GrpE; Region: GrpE; pfam01025
391904000461	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
391904000462	dimer interface [polypeptide binding]; other site
391904000463	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
391904000464	chaperone protein DnaJ; Provisional; Region: PRK14299
391904000465	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
391904000466	HSP70 interaction site [polypeptide binding]; other site
391904000467	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
391904000468	substrate binding site [polypeptide binding]; other site
391904000469	dimer interface [polypeptide binding]; other site
391904000470	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
391904000471	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
391904000472	DNA binding residues [nucleotide binding]
391904000473	putative dimer interface [polypeptide binding]; other site
391904000474	xanthine permease; Region: pbuX; TIGR03173
391904000475	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
391904000476	Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080
391904000477	Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893
391904000478	putative catalytic cysteine [active]
391904000479	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
391904000480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391904000481	NAD(P) binding site [chemical binding]; other site
391904000482	active site
391904000483	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
391904000484	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904000485	motif II; other site
391904000486	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
391904000487	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
391904000488	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
391904000489	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391904000490	ATP binding site [chemical binding]; other site
391904000491	Walker B motif; other site
391904000492	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
391904000493	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
391904000494	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
391904000495	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
391904000496	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
391904000497	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391904000498	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904000499	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
391904000500	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904000501	Walker A motif; other site
391904000502	ATP binding site [chemical binding]; other site
391904000503	Walker B motif; other site
391904000504	arginine finger; other site
391904000505	recombination protein RecR; Reviewed; Region: recR; PRK00076
391904000506	RecR protein; Region: RecR; pfam02132
391904000507	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
391904000508	putative active site [active]
391904000509	putative metal-binding site [ion binding]; other site
391904000510	tetramer interface [polypeptide binding]; other site
391904000511	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
391904000512	active site
391904000513	catalytic site [active]
391904000514	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904000515	aspartate kinase; Reviewed; Region: PRK06635
391904000516	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
391904000517	putative nucleotide binding site [chemical binding]; other site
391904000518	putative catalytic residues [active]
391904000519	putative Mg ion binding site [ion binding]; other site
391904000520	putative aspartate binding site [chemical binding]; other site
391904000521	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
391904000522	putative allosteric regulatory site; other site
391904000523	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
391904000524	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
391904000525	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
391904000526	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
391904000527	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
391904000528	metal binding site [ion binding]; metal-binding site
391904000529	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
391904000530	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
391904000531	2-isopropylmalate synthase; Validated; Region: PRK03739
391904000532	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
391904000533	active site
391904000534	catalytic residues [active]
391904000535	metal binding site [ion binding]; metal-binding site
391904000536	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
391904000537	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
391904000538	Transglycosylase; Region: Transgly; pfam00912
391904000539	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
391904000540	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
391904000541	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
391904000542	active site
391904000543	interdomain interaction site; other site
391904000544	putative metal-binding site [ion binding]; other site
391904000545	nucleotide binding site [chemical binding]; other site
391904000546	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
391904000547	domain I; other site
391904000548	phosphate binding site [ion binding]; other site
391904000549	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
391904000550	domain II; other site
391904000551	domain III; other site
391904000552	nucleotide binding site [chemical binding]; other site
391904000553	DNA binding groove [nucleotide binding]
391904000554	catalytic site [active]
391904000555	domain IV; other site
391904000556	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
391904000557	thymidylate kinase; Validated; Region: tmk; PRK00698
391904000558	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
391904000559	TMP-binding site; other site
391904000560	ATP-binding site [chemical binding]; other site
391904000561	DNA polymerase III subunit delta'; Validated; Region: PRK07940
391904000562	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
391904000563	Walker A motif; other site
391904000564	ATP binding site [chemical binding]; other site
391904000565	DNA polymerase III subunit delta'; Validated; Region: PRK08485
391904000566	Walker B motif; other site
391904000567	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
391904000568	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904000569	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904000570	dimerization interface [polypeptide binding]; other site
391904000571	ligand binding site [chemical binding]; other site
391904000572	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
391904000573	dimerization domain swap beta strand [polypeptide binding]; other site
391904000574	regulatory protein interface [polypeptide binding]; other site
391904000575	active site
391904000576	regulatory phosphorylation site [posttranslational modification]; other site
391904000577	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
391904000578	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
391904000579	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
391904000580	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
391904000581	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
391904000582	substrate binding site [chemical binding]; other site
391904000583	Peptidase family C69; Region: Peptidase_C69; pfam03577
391904000584	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
391904000585	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
391904000586	macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450
391904000587	Predicted membrane protein [Function unknown]; Region: COG2246
391904000588	GtrA-like protein; Region: GtrA; pfam04138
391904000589	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
391904000590	Divergent AAA domain; Region: AAA_4; pfam04326
391904000591	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
391904000592	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
391904000593	putative DNA binding site [nucleotide binding]; other site
391904000594	putative Zn2+ binding site [ion binding]; other site
391904000595	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904000596	catalytic core [active]
391904000597	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
391904000598	active site
391904000599	phosphate binding residues; other site
391904000600	catalytic residues [active]
391904000601	Predicted membrane protein [Function unknown]; Region: COG3152
391904000602	Abi-like protein; Region: Abi_2; cl01988
391904000603	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
391904000604	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
391904000605	HIGH motif; other site
391904000606	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
391904000607	active site
391904000608	KMSKS motif; other site
391904000609	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
391904000610	Divergent AAA domain; Region: AAA_4; pfam04326
391904000611	Iron permease FTR1 family; Region: FTR1; cl00475
391904000612	Fe2+ transport protein; Region: Iron_transport; pfam10634
391904000613	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
391904000614	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904000615	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
391904000616	FtsX-like permease family; Region: FtsX; pfam02687
391904000617	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
391904000618	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
391904000619	FtsX-like permease family; Region: FtsX; pfam02687
391904000620	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904000621	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904000622	Walker A/P-loop; other site
391904000623	ATP binding site [chemical binding]; other site
391904000624	Q-loop/lid; other site
391904000625	ABC transporter signature motif; other site
391904000626	Walker B; other site
391904000627	D-loop; other site
391904000628	H-loop/switch region; other site
391904000629	FMN-binding domain; Region: FMN_bind; cl01081
391904000630	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391904000631	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904000632	Predicted membrane protein [Function unknown]; Region: COG1511
391904000633	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
391904000634	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
391904000635	Predicted membrane protein [Function unknown]; Region: COG1511
391904000636	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
391904000637	Predicted membrane protein [Function unknown]; Region: COG1511
391904000638	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
391904000639	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
391904000640	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
391904000641	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
391904000642	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
391904000643	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
391904000644	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
391904000645	putative active site [active]
391904000646	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
391904000647	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
391904000648	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
391904000649	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
391904000650	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
391904000651	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
391904000652	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904000653	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904000654	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904000655	active site
391904000656	phosphorylation site [posttranslational modification]
391904000657	intermolecular recognition site; other site
391904000658	dimerization interface [polypeptide binding]; other site
391904000659	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904000660	DNA binding residues [nucleotide binding]
391904000661	dimerization interface [polypeptide binding]; other site
391904000662	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
391904000663	Peptidase family C69; Region: Peptidase_C69; pfam03577
391904000664	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391904000665	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391904000666	active site
391904000667	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391904000668	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904000669	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
391904000670	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
391904000671	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
391904000672	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
391904000673	P loop; other site
391904000674	GTP binding site [chemical binding]; other site
391904000675	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
391904000676	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
391904000677	Nitrogen regulatory protein P-II; Region: P-II; smart00938
391904000678	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
391904000679	metal binding triad; other site
391904000680	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
391904000681	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
391904000682	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
391904000683	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
391904000684	replicative DNA helicase; Region: DnaB; TIGR00665
391904000685	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
391904000686	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
391904000687	Walker A motif; other site
391904000688	ATP binding site [chemical binding]; other site
391904000689	Walker B motif; other site
391904000690	DNA binding loops [nucleotide binding]
391904000691	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391904000692	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
391904000693	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
391904000694	catalytic triad [active]
391904000695	Uncharacterized conserved protein [Function unknown]; Region: COG3937
391904000696	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
391904000697	ABC1 family; Region: ABC1; pfam03109
391904000698	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
391904000699	active site
391904000700	ATP binding site [chemical binding]; other site
391904000701	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690
391904000702	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
391904000703	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
391904000704	catalytic residue [active]
391904000705	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
391904000706	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
391904000707	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904000708	active site
391904000709	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
391904000710	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
391904000711	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
391904000712	dimer interface [polypeptide binding]; other site
391904000713	ssDNA binding site [nucleotide binding]; other site
391904000714	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904000715	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
391904000716	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
391904000717	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
391904000718	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
391904000719	Transposase; Region: DDE_Tnp_ISL3; pfam01610
391904000720	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904000721	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
391904000722	Walker A/P-loop; other site
391904000723	ATP binding site [chemical binding]; other site
391904000724	Q-loop/lid; other site
391904000725	ABC transporter signature motif; other site
391904000726	Walker B; other site
391904000727	D-loop; other site
391904000728	H-loop/switch region; other site
391904000729	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904000730	Walker B; other site
391904000731	D-loop; other site
391904000732	H-loop/switch region; other site
391904000733	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904000734	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904000735	DNA binding residues [nucleotide binding]
391904000736	dimerization interface [polypeptide binding]; other site
391904000737	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904000738	glucuronide transporter; Provisional; Region: PRK09848
391904000739	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904000740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000741	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904000742	putative substrate translocation pore; other site
391904000743	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
391904000744	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
391904000745	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
391904000746	amphipathic channel; other site
391904000747	Asn-Pro-Ala signature motifs; other site
391904000748	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
391904000749	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
391904000750	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
391904000751	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904000752	active site
391904000753	motif I; other site
391904000754	motif II; other site
391904000755	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
391904000756	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
391904000757	putative homodimer interface [polypeptide binding]; other site
391904000758	putative homotetramer interface [polypeptide binding]; other site
391904000759	putative allosteric switch controlling residues; other site
391904000760	putative metal binding site [ion binding]; other site
391904000761	putative homodimer-homodimer interface [polypeptide binding]; other site
391904000762	RmuC family; Region: RmuC; pfam02646
391904000763	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
391904000764	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
391904000765	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
391904000766	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
391904000767	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
391904000768	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
391904000769	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
391904000770	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
391904000771	GatB domain; Region: GatB_Yqey; pfam02637
391904000772	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
391904000773	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
391904000774	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
391904000775	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
391904000776	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
391904000777	hypothetical protein; Provisional; Region: PRK07208
391904000778	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391904000779	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
391904000780	transcription termination factor Rho; Provisional; Region: PRK12608
391904000781	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
391904000782	RNA binding site [nucleotide binding]; other site
391904000783	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
391904000784	multimer interface [polypeptide binding]; other site
391904000785	Walker A motif; other site
391904000786	ATP binding site [chemical binding]; other site
391904000787	Walker B motif; other site
391904000788	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904000789	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904000790	DNA binding site [nucleotide binding]
391904000791	domain linker motif; other site
391904000792	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904000793	dimerization interface [polypeptide binding]; other site
391904000794	ligand binding site [chemical binding]; other site
391904000795	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
391904000796	MFS/sugar transport protein; Region: MFS_2; pfam13347
391904000797	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
391904000798	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
391904000799	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
391904000800	Transposase; Region: DDE_Tnp_ISL3; pfam01610
391904000801	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
391904000802	Transposase, Mutator family; Region: Transposase_mut; pfam00872
391904000803	MULE transposase domain; Region: MULE; pfam10551
391904000804	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904000805	DNA binding site [nucleotide binding]
391904000806	active site
391904000807	Int/Topo IB signature motif; other site
391904000808	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904000809	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
391904000810	active site
391904000811	Int/Topo IB signature motif; other site
391904000812	DNA binding site [nucleotide binding]
391904000813	Integrase core domain; Region: rve; pfam00665
391904000814	Integrase core domain; Region: rve_2; pfam13333
391904000815	monofunctional chorismate mutase, alpha proteobacterial type; Region: CM_mono_cladeE; TIGR01795
391904000816	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
391904000817	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391904000818	active site
391904000819	HIGH motif; other site
391904000820	nucleotide binding site [chemical binding]; other site
391904000821	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391904000822	active site
391904000823	KMSKS motif; other site
391904000824	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
391904000825	tRNA binding surface [nucleotide binding]; other site
391904000826	anticodon binding site; other site
391904000827	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
391904000828	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
391904000829	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
391904000830	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
391904000831	minor groove reading motif; other site
391904000832	helix-hairpin-helix signature motif; other site
391904000833	substrate binding pocket [chemical binding]; other site
391904000834	active site
391904000835	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
391904000836	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904000837	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391904000838	DNA binding site [nucleotide binding]
391904000839	Predicted membrane protein [Function unknown]; Region: COG1971
391904000840	Domain of unknown function DUF; Region: DUF204; pfam02659
391904000841	Domain of unknown function DUF; Region: DUF204; pfam02659
391904000842	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
391904000843	dimer interface [polypeptide binding]; other site
391904000844	substrate binding site [chemical binding]; other site
391904000845	metal binding sites [ion binding]; metal-binding site
391904000846	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
391904000847	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
391904000848	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
391904000849	active site
391904000850	homodimer interface [polypeptide binding]; other site
391904000851	catalytic site [active]
391904000852	acceptor binding site [chemical binding]; other site
391904000853	Transposase IS200 like; Region: Y1_Tnp; cl00848
391904000854	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
391904000855	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
391904000856	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904000857	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
391904000858	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
391904000859	Int/Topo IB signature motif; other site
391904000860	potential frameshift: common BLAST hit: gi|311063473|ref|YP_003970198.1| Type II restriction-modification system restriction subunit
391904000861	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
391904000862	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
391904000863	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011
391904000864	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
391904000865	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
391904000866	dimer interface [polypeptide binding]; other site
391904000867	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
391904000868	ligand binding site [chemical binding]; other site
391904000869	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904000870	non-specific DNA binding site [nucleotide binding]; other site
391904000871	salt bridge; other site
391904000872	sequence-specific DNA binding site [nucleotide binding]; other site
391904000873	Plasmid replication protein; Region: Rep_2; pfam01719
391904000874	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391904000875	Walker A motif; other site
391904000876	ATP binding site [chemical binding]; other site
391904000877	Walker B motif; other site
391904000878	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
391904000879	non-specific DNA binding site [nucleotide binding]; other site
391904000880	salt bridge; other site
391904000881	sequence-specific DNA binding site [nucleotide binding]; other site
391904000882	Protein of unknown function (DUF497); Region: DUF497; pfam04365
391904000883	homoserine O-succinyltransferase; Provisional; Region: PRK05368
391904000884	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
391904000885	proposed active site lysine [active]
391904000886	conserved cys residue [active]
391904000887	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
391904000888	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
391904000889	ATP synthase subunit C; Region: ATP-synt_C; cl00466
391904000890	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
391904000891	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
391904000892	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
391904000893	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
391904000894	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
391904000895	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
391904000896	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
391904000897	beta subunit interaction interface [polypeptide binding]; other site
391904000898	Walker A motif; other site
391904000899	ATP binding site [chemical binding]; other site
391904000900	Walker B motif; other site
391904000901	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
391904000902	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
391904000903	core domain interface [polypeptide binding]; other site
391904000904	delta subunit interface [polypeptide binding]; other site
391904000905	epsilon subunit interface [polypeptide binding]; other site
391904000906	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
391904000907	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
391904000908	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
391904000909	alpha subunit interaction interface [polypeptide binding]; other site
391904000910	Walker A motif; other site
391904000911	ATP binding site [chemical binding]; other site
391904000912	Walker B motif; other site
391904000913	inhibitor binding site; inhibition site
391904000914	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
391904000915	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
391904000916	gamma subunit interface [polypeptide binding]; other site
391904000917	epsilon subunit interface [polypeptide binding]; other site
391904000918	LBP interface [polypeptide binding]; other site
391904000919	hypothetical protein; Provisional; Region: PRK03298
391904000920	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
391904000921	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
391904000922	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
391904000923	putative active site [active]
391904000924	putative metal binding residues [ion binding]; other site
391904000925	signature motif; other site
391904000926	putative dimer interface [polypeptide binding]; other site
391904000927	putative phosphate binding site [ion binding]; other site
391904000928	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
391904000929	homotrimer interaction site [polypeptide binding]; other site
391904000930	putative active site [active]
391904000931	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
391904000932	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
391904000933	putative acyl-acceptor binding pocket; other site
391904000934	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
391904000935	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
391904000936	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
391904000937	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
391904000938	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
391904000939	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
391904000940	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
391904000941	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
391904000942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
391904000943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000944	dimer interface [polypeptide binding]; other site
391904000945	conserved gate region; other site
391904000946	putative PBP binding loops; other site
391904000947	ABC-ATPase subunit interface; other site
391904000948	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
391904000949	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904000950	Walker A/P-loop; other site
391904000951	ATP binding site [chemical binding]; other site
391904000952	Q-loop/lid; other site
391904000953	ABC transporter signature motif; other site
391904000954	Walker B; other site
391904000955	D-loop; other site
391904000956	H-loop/switch region; other site
391904000957	TOBE domain; Region: TOBE_2; pfam08402
391904000958	CAAX protease self-immunity; Region: Abi; pfam02517
391904000959	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
391904000960	Mechanosensitive ion channel; Region: MS_channel; pfam00924
391904000961	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
391904000962	Aspartase; Region: Aspartase; cd01357
391904000963	active sites [active]
391904000964	tetramer interface [polypeptide binding]; other site
391904000965	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391904000966	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904000967	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
391904000968	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391904000969	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
391904000970	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
391904000971	DNA binding site [nucleotide binding]
391904000972	active site
391904000973	RelB antitoxin; Region: RelB; cl01171
391904000974	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
391904000975	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
391904000976	DNA binding residues [nucleotide binding]
391904000977	dimer interface [polypeptide binding]; other site
391904000978	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
391904000979	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000980	putative substrate translocation pore; other site
391904000981	YegV-like sugar kinase.  Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944
391904000982	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
391904000983	substrate binding site [chemical binding]; other site
391904000984	ATP binding site [chemical binding]; other site
391904000985	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
391904000986	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
391904000987	ssDNA binding site; other site
391904000988	generic binding surface II; other site
391904000989	DEAD-like helicases superfamily; Region: DEXDc; smart00487
391904000990	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904000991	ATP binding site [chemical binding]; other site
391904000992	putative Mg++ binding site [ion binding]; other site
391904000993	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904000994	nucleotide binding region [chemical binding]; other site
391904000995	ATP-binding site [chemical binding]; other site
391904000996	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904000997	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904000998	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
391904000999	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001000	dimer interface [polypeptide binding]; other site
391904001001	conserved gate region; other site
391904001002	putative PBP binding loops; other site
391904001003	ABC-ATPase subunit interface; other site
391904001004	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904001005	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001006	dimer interface [polypeptide binding]; other site
391904001007	conserved gate region; other site
391904001008	putative PBP binding loops; other site
391904001009	ABC-ATPase subunit interface; other site
391904001010	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904001011	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904001012	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
391904001013	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
391904001014	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001015	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904001016	putative substrate translocation pore; other site
391904001017	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
391904001018	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
391904001019	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
391904001020	Domain of unknown function (DUF3841); Region: DUF3841; pfam12952
391904001021	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
391904001022	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
391904001023	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
391904001024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904001025	S-adenosylmethionine binding site [chemical binding]; other site
391904001026	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
391904001027	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
391904001028	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
391904001029	Peptidase family U32; Region: Peptidase_U32; pfam01136
391904001030	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
391904001031	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
391904001032	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
391904001033	substrate binding site; other site
391904001034	dimer interface; other site
391904001035	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
391904001036	putative substrate binding pocket [chemical binding]; other site
391904001037	AC domain interface; other site
391904001038	catalytic triad [active]
391904001039	AB domain interface; other site
391904001040	interchain disulfide; other site
391904001041	DivIVA protein; Region: DivIVA; pfam05103
391904001042	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
391904001043	trimer interface [polypeptide binding]; other site
391904001044	active site
391904001045	G bulge; other site
391904001046	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
391904001047	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
391904001048	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
391904001049	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
391904001050	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
391904001051	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
391904001052	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001053	metabolite-proton symporter; Region: 2A0106; TIGR00883
391904001054	putative substrate translocation pore; other site
391904001055	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
391904001056	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391904001057	dimer interface [polypeptide binding]; other site
391904001058	phosphorylation site [posttranslational modification]
391904001059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904001060	ATP binding site [chemical binding]; other site
391904001061	Mg2+ binding site [ion binding]; other site
391904001062	G-X-G motif; other site
391904001063	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904001064	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001065	active site
391904001066	phosphorylation site [posttranslational modification]
391904001067	intermolecular recognition site; other site
391904001068	dimerization interface [polypeptide binding]; other site
391904001069	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391904001070	DNA binding site [nucleotide binding]
391904001071	PBP superfamily domain; Region: PBP_like_2; cl17296
391904001072	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
391904001073	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001074	dimer interface [polypeptide binding]; other site
391904001075	conserved gate region; other site
391904001076	putative PBP binding loops; other site
391904001077	ABC-ATPase subunit interface; other site
391904001078	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
391904001079	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001080	dimer interface [polypeptide binding]; other site
391904001081	conserved gate region; other site
391904001082	putative PBP binding loops; other site
391904001083	ABC-ATPase subunit interface; other site
391904001084	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
391904001085	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
391904001086	Walker A/P-loop; other site
391904001087	ATP binding site [chemical binding]; other site
391904001088	Q-loop/lid; other site
391904001089	ABC transporter signature motif; other site
391904001090	Walker B; other site
391904001091	D-loop; other site
391904001092	H-loop/switch region; other site
391904001093	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
391904001094	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
391904001095	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
391904001096	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
391904001097	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904001098	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
391904001099	active site
391904001100	catalytic tetrad [active]
391904001101	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
391904001102	active site
391904001103	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001104	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904001105	DNA binding site [nucleotide binding]
391904001106	domain linker motif; other site
391904001107	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904001108	dimerization interface [polypeptide binding]; other site
391904001109	ligand binding site [chemical binding]; other site
391904001110	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
391904001111	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904001112	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001113	dimer interface [polypeptide binding]; other site
391904001114	conserved gate region; other site
391904001115	putative PBP binding loops; other site
391904001116	ABC-ATPase subunit interface; other site
391904001117	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904001118	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001119	dimer interface [polypeptide binding]; other site
391904001120	conserved gate region; other site
391904001121	putative PBP binding loops; other site
391904001122	ABC-ATPase subunit interface; other site
391904001123	HipA N-terminal domain; Region: Couple_hipA; cl11853
391904001124	HipA-like N-terminal domain; Region: HipA_N; pfam07805
391904001125	HipA-like C-terminal domain; Region: HipA_C; pfam07804
391904001126	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
391904001127	RimM N-terminal domain; Region: RimM; pfam01782
391904001128	hypothetical protein; Provisional; Region: PRK02821
391904001129	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
391904001130	G-X-X-G motif; other site
391904001131	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
391904001132	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
391904001133	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
391904001134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904001135	catalytic residue [active]
391904001136	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
391904001137	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
391904001138	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
391904001139	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
391904001140	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
391904001141	catalytic motif [active]
391904001142	Zn binding site [ion binding]; other site
391904001143	RibD C-terminal domain; Region: RibD_C; cl17279
391904001144	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
391904001145	Lumazine binding domain; Region: Lum_binding; pfam00677
391904001146	Lumazine binding domain; Region: Lum_binding; pfam00677
391904001147	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
391904001148	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
391904001149	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
391904001150	dimerization interface [polypeptide binding]; other site
391904001151	active site
391904001152	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
391904001153	homopentamer interface [polypeptide binding]; other site
391904001154	active site
391904001155	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
391904001156	putative catalytic site [active]
391904001157	putative metal binding site [ion binding]; other site
391904001158	putative phosphate binding site [ion binding]; other site
391904001159	signal recognition particle protein; Provisional; Region: PRK10867
391904001160	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
391904001161	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
391904001162	P loop; other site
391904001163	GTP binding site [chemical binding]; other site
391904001164	Signal peptide binding domain; Region: SRP_SPB; pfam02978
391904001165	Cation efflux family; Region: Cation_efflux; pfam01545
391904001166	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
391904001167	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391904001168	active site
391904001169	HIGH motif; other site
391904001170	nucleotide binding site [chemical binding]; other site
391904001171	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
391904001172	KMSKS motif; other site
391904001173	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
391904001174	tRNA binding surface [nucleotide binding]; other site
391904001175	anticodon binding site; other site
391904001176	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
391904001177	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
391904001178	catalytic triad [active]
391904001179	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904001180	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904001181	ABC transporter; Region: ABC_tran_2; pfam12848
391904001182	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904001183	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904001184	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
391904001185	oligomeric interface; other site
391904001186	putative active site [active]
391904001187	homodimer interface [polypeptide binding]; other site
391904001188	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
391904001189	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
391904001190	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
391904001191	putative valine binding site [chemical binding]; other site
391904001192	dimer interface [polypeptide binding]; other site
391904001193	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
391904001194	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
391904001195	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
391904001196	PYR/PP interface [polypeptide binding]; other site
391904001197	dimer interface [polypeptide binding]; other site
391904001198	TPP binding site [chemical binding]; other site
391904001199	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
391904001200	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
391904001201	TPP-binding site [chemical binding]; other site
391904001202	dimer interface [polypeptide binding]; other site
391904001203	ribonuclease III; Reviewed; Region: rnc; PRK00102
391904001204	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
391904001205	dimerization interface [polypeptide binding]; other site
391904001206	active site
391904001207	metal binding site [ion binding]; metal-binding site
391904001208	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
391904001209	dsRNA binding site [nucleotide binding]; other site
391904001210	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
391904001211	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
391904001212	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
391904001213	active site
391904001214	(T/H)XGH motif; other site
391904001215	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
391904001216	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904001217	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
391904001218	active site
391904001219	catalytic tetrad [active]
391904001220	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
391904001221	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
391904001222	DNA binding residues [nucleotide binding]
391904001223	putative dimer interface [polypeptide binding]; other site
391904001224	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
391904001225	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
391904001226	active site
391904001227	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
391904001228	non-specific DNA binding site [nucleotide binding]; other site
391904001229	salt bridge; other site
391904001230	sequence-specific DNA binding site [nucleotide binding]; other site
391904001231	ribonuclease PH; Reviewed; Region: rph; PRK00173
391904001232	Ribonuclease PH; Region: RNase_PH_bact; cd11362
391904001233	hexamer interface [polypeptide binding]; other site
391904001234	active site
391904001235	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
391904001236	active site
391904001237	dimerization interface [polypeptide binding]; other site
391904001238	FemAB family; Region: FemAB; pfam02388
391904001239	FemAB family; Region: FemAB; pfam02388
391904001240	FemAB family; Region: FemAB; pfam02388
391904001241	Membrane transport protein; Region: Mem_trans; cl09117
391904001242	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
391904001243	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
391904001244	active site
391904001245	dimer interface [polypeptide binding]; other site
391904001246	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
391904001247	dimer interface [polypeptide binding]; other site
391904001248	active site
391904001249	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
391904001250	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
391904001251	Walker A/P-loop; other site
391904001252	ATP binding site [chemical binding]; other site
391904001253	Q-loop/lid; other site
391904001254	ABC transporter signature motif; other site
391904001255	Walker B; other site
391904001256	D-loop; other site
391904001257	H-loop/switch region; other site
391904001258	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
391904001259	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
391904001260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001261	dimer interface [polypeptide binding]; other site
391904001262	conserved gate region; other site
391904001263	putative PBP binding loops; other site
391904001264	ABC-ATPase subunit interface; other site
391904001265	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001266	dimer interface [polypeptide binding]; other site
391904001267	conserved gate region; other site
391904001268	putative PBP binding loops; other site
391904001269	ABC-ATPase subunit interface; other site
391904001270	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
391904001271	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
391904001272	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
391904001273	Catalytic site [active]
391904001274	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
391904001275	RNA/DNA hybrid binding site [nucleotide binding]; other site
391904001276	active site
391904001277	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001278	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904001279	DNA binding site [nucleotide binding]
391904001280	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
391904001281	ligand binding site [chemical binding]; other site
391904001282	dimerization interface (open form) [polypeptide binding]; other site
391904001283	dimerization interface (closed form) [polypeptide binding]; other site
391904001284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001285	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904001286	putative substrate translocation pore; other site
391904001287	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
391904001288	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
391904001289	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
391904001290	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
391904001291	acyl-activating enzyme (AAE) consensus motif; other site
391904001292	putative AMP binding site [chemical binding]; other site
391904001293	putative active site [active]
391904001294	putative CoA binding site [chemical binding]; other site
391904001295	potential frameshift: common BLAST hit: gi|322690542|ref|YP_004220112.1| ABC transporter ATP-binding protein
391904001296	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
391904001297	Walker A/P-loop; other site
391904001298	ATP binding site [chemical binding]; other site
391904001299	Q-loop/lid; other site
391904001300	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
391904001301	Walker A/P-loop; other site
391904001302	ATP binding site [chemical binding]; other site
391904001303	ABC transporter; Region: ABC_tran; pfam00005
391904001304	Q-loop/lid; other site
391904001305	ABC transporter signature motif; other site
391904001306	Walker B; other site
391904001307	D-loop; other site
391904001308	H-loop/switch region; other site
391904001309	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
391904001310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001311	putative substrate translocation pore; other site
391904001312	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001313	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904001314	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904001315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001316	active site
391904001317	phosphorylation site [posttranslational modification]
391904001318	intermolecular recognition site; other site
391904001319	dimerization interface [polypeptide binding]; other site
391904001320	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904001321	DNA binding residues [nucleotide binding]
391904001322	dimerization interface [polypeptide binding]; other site
391904001323	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
391904001324	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
391904001325	Transposase; Region: DDE_Tnp_ISL3; pfam01610
391904001326	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
391904001327	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001328	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904001329	DNA binding site [nucleotide binding]
391904001330	domain linker motif; other site
391904001331	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904001332	ligand binding site [chemical binding]; other site
391904001333	dimerization interface [polypeptide binding]; other site
391904001334	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
391904001335	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
391904001336	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904001337	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
391904001338	active site
391904001339	catalytic tetrad [active]
391904001340	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
391904001341	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
391904001342	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
391904001343	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001344	putative substrate translocation pore; other site
391904001345	D-galactonate transporter; Region: 2A0114; TIGR00893
391904001346	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001347	putative substrate translocation pore; other site
391904001348	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
391904001349	Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896
391904001350	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904001351	Integrase core domain; Region: rve; pfam00665
391904001352	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
391904001353	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904001354	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904001355	active site
391904001356	DNA binding site [nucleotide binding]
391904001357	Int/Topo IB signature motif; other site
391904001358	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
391904001359	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
391904001360	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
391904001361	putative active site [active]
391904001362	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904001363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001364	dimer interface [polypeptide binding]; other site
391904001365	conserved gate region; other site
391904001366	putative PBP binding loops; other site
391904001367	ABC-ATPase subunit interface; other site
391904001368	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001369	dimer interface [polypeptide binding]; other site
391904001370	conserved gate region; other site
391904001371	putative PBP binding loops; other site
391904001372	ABC-ATPase subunit interface; other site
391904001373	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904001374	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
391904001375	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904001376	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904001377	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001378	active site
391904001379	phosphorylation site [posttranslational modification]
391904001380	intermolecular recognition site; other site
391904001381	dimerization interface [polypeptide binding]; other site
391904001382	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
391904001383	DNA binding residues [nucleotide binding]
391904001384	Histidine kinase; Region: HisKA_3; pfam07730
391904001385	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
391904001386	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
391904001387	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904001388	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904001389	Walker A/P-loop; other site
391904001390	ATP binding site [chemical binding]; other site
391904001391	Q-loop/lid; other site
391904001392	ABC transporter signature motif; other site
391904001393	Walker B; other site
391904001394	D-loop; other site
391904001395	H-loop/switch region; other site
391904001396	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
391904001397	active site
391904001398	substrate binding site [chemical binding]; other site
391904001399	ATP binding site [chemical binding]; other site
391904001400	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
391904001401	activation loop (A-loop); other site
391904001402	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
391904001403	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
391904001404	active site
391904001405	zinc binding site [ion binding]; other site
391904001406	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904001407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001408	active site
391904001409	phosphorylation site [posttranslational modification]
391904001410	intermolecular recognition site; other site
391904001411	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904001412	DNA binding residues [nucleotide binding]
391904001413	dimerization interface [polypeptide binding]; other site
391904001414	Histidine kinase; Region: HisKA_3; pfam07730
391904001415	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904001416	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904001417	Walker A/P-loop; other site
391904001418	ATP binding site [chemical binding]; other site
391904001419	Q-loop/lid; other site
391904001420	ABC transporter signature motif; other site
391904001421	Walker B; other site
391904001422	D-loop; other site
391904001423	H-loop/switch region; other site
391904001424	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904001425	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904001426	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001427	Walker A/P-loop; other site
391904001428	ATP binding site [chemical binding]; other site
391904001429	Q-loop/lid; other site
391904001430	ABC transporter signature motif; other site
391904001431	Walker B; other site
391904001432	D-loop; other site
391904001433	H-loop/switch region; other site
391904001434	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
391904001435	Ligand Binding Site [chemical binding]; other site
391904001436	Molecular Tunnel; other site
391904001437	CutC family; Region: CutC; cl01218
391904001438	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
391904001439	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001440	Walker A/P-loop; other site
391904001441	ATP binding site [chemical binding]; other site
391904001442	Q-loop/lid; other site
391904001443	ABC transporter signature motif; other site
391904001444	Walker B; other site
391904001445	D-loop; other site
391904001446	H-loop/switch region; other site
391904001447	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904001448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001449	active site
391904001450	phosphorylation site [posttranslational modification]
391904001451	intermolecular recognition site; other site
391904001452	dimerization interface [polypeptide binding]; other site
391904001453	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904001454	DNA binding residues [nucleotide binding]
391904001455	dimerization interface [polypeptide binding]; other site
391904001456	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904001457	Histidine kinase; Region: HisKA_3; pfam07730
391904001458	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
391904001459	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
391904001460	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904001461	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391904001462	Walker A/P-loop; other site
391904001463	ATP binding site [chemical binding]; other site
391904001464	Q-loop/lid; other site
391904001465	ABC transporter signature motif; other site
391904001466	Walker B; other site
391904001467	D-loop; other site
391904001468	3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640
391904001469	H-loop/switch region; other site
391904001470	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904001471	Int/Topo IB signature motif; other site
391904001472	DNA binding site [nucleotide binding]
391904001473	active site
391904001474	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
391904001475	FAD binding pocket [chemical binding]; other site
391904001476	conserved FAD binding motif [chemical binding]; other site
391904001477	phosphate binding motif [ion binding]; other site
391904001478	beta-alpha-beta structure motif; other site
391904001479	NAD binding pocket [chemical binding]; other site
391904001480	aspartate aminotransferase; Provisional; Region: PRK05764
391904001481	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904001482	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904001483	homodimer interface [polypeptide binding]; other site
391904001484	catalytic residue [active]
391904001485	pyrrolysine biosynthesis protein PylC; Region: pyrrolys_PylC; TIGR03909
391904001486	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
391904001487	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
391904001488	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904001489	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
391904001490	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
391904001491	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904001492	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904001493	Winged helix-turn helix; Region: HTH_29; pfam13551
391904001494	putative transposase OrfB; Reviewed; Region: PHA02517
391904001495	HTH-like domain; Region: HTH_21; pfam13276
391904001496	Integrase core domain; Region: rve; pfam00665
391904001497	Integrase core domain; Region: rve_2; pfam13333
391904001498	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904001499	active site
391904001500	Int/Topo IB signature motif; other site
391904001501	DNA binding site [nucleotide binding]
391904001502	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904001503	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904001504	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904001505	DNA binding residues [nucleotide binding]
391904001506	dimerization interface [polypeptide binding]; other site
391904001507	PrgI family protein; Region: PrgI; pfam12666
391904001508	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391904001509	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391904001510	dimer interface [polypeptide binding]; other site
391904001511	phosphorylation site [posttranslational modification]
391904001512	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904001513	ATP binding site [chemical binding]; other site
391904001514	Mg2+ binding site [ion binding]; other site
391904001515	G-X-G motif; other site
391904001516	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904001517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001518	active site
391904001519	phosphorylation site [posttranslational modification]
391904001520	intermolecular recognition site; other site
391904001521	dimerization interface [polypeptide binding]; other site
391904001522	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391904001523	DNA binding site [nucleotide binding]
391904001524	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
391904001525	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001526	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904001527	Walker A/P-loop; other site
391904001528	ATP binding site [chemical binding]; other site
391904001529	Q-loop/lid; other site
391904001530	ABC transporter signature motif; other site
391904001531	Walker B; other site
391904001532	D-loop; other site
391904001533	H-loop/switch region; other site
391904001534	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001535	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904001536	DNA binding site [nucleotide binding]
391904001537	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904001538	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001539	ABC transporter signature motif; other site
391904001540	Walker B; other site
391904001541	D-loop; other site
391904001542	H-loop/switch region; other site
391904001543	SpaB C-terminal domain; Region: SpaB_C; cl14828
391904001544	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
391904001545	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
391904001546	active site
391904001547	zinc binding site [ion binding]; other site
391904001548	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001549	ABC transporter signature motif; other site
391904001550	Walker B; other site
391904001551	D-loop; other site
391904001552	H-loop/switch region; other site
391904001553	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
391904001554	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904001555	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904001556	non-specific DNA binding site [nucleotide binding]; other site
391904001557	salt bridge; other site
391904001558	sequence-specific DNA binding site [nucleotide binding]; other site
391904001559	Domain of unknown function (DUF955); Region: DUF955; cl01076
391904001560	hypothetical protein; Region: PHA01623
391904001561	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
391904001562	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
391904001563	P-loop; other site
391904001564	Magnesium ion binding site [ion binding]; other site
391904001565	Transcription factor WhiB; Region: Whib; pfam02467
391904001566	Helix-turn-helix domain; Region: HTH_36; pfam13730
391904001567	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
391904001568	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
391904001569	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391904001570	NAD(P) binding site [chemical binding]; other site
391904001571	active site
391904001572	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
391904001573	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904001574	S-adenosylmethionine binding site [chemical binding]; other site
391904001575	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
391904001576	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
391904001577	dimer interface [polypeptide binding]; other site
391904001578	active site
391904001579	metal binding site [ion binding]; metal-binding site
391904001580	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
391904001581	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391904001582	active site
391904001583	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391904001584	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
391904001585	Domain of unknown function DUF20; Region: UPF0118; pfam01594
391904001586	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
391904001587	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
391904001588	DXD motif; other site
391904001589	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391904001590	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391904001591	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
391904001592	Walker A/P-loop; other site
391904001593	ATP binding site [chemical binding]; other site
391904001594	Q-loop/lid; other site
391904001595	ABC transporter signature motif; other site
391904001596	Walker B; other site
391904001597	D-loop; other site
391904001598	H-loop/switch region; other site
391904001599	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
391904001600	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
391904001601	Ligand Binding Site [chemical binding]; other site
391904001602	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
391904001603	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904001604	active site
391904001605	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
391904001606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904001607	Walker A motif; other site
391904001608	ATP binding site [chemical binding]; other site
391904001609	Walker B motif; other site
391904001610	arginine finger; other site
391904001611	Peptidase family M41; Region: Peptidase_M41; pfam01434
391904001612	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
391904001613	GTP cyclohydrolase I; Provisional; Region: PLN03044
391904001614	active site
391904001615	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
391904001616	dihydropteroate synthase; Region: DHPS; TIGR01496
391904001617	substrate binding pocket [chemical binding]; other site
391904001618	dimer interface [polypeptide binding]; other site
391904001619	inhibitor binding site; inhibition site
391904001620	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
391904001621	homooctamer interface [polypeptide binding]; other site
391904001622	active site
391904001623	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
391904001624	catalytic center binding site [active]
391904001625	ATP binding site [chemical binding]; other site
391904001626	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
391904001627	catalytic center binding site [active]
391904001628	ATP binding site [chemical binding]; other site
391904001629	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
391904001630	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
391904001631	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
391904001632	active site
391904001633	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
391904001634	catalytic triad [active]
391904001635	dimer interface [polypeptide binding]; other site
391904001636	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
391904001637	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001638	Walker A/P-loop; other site
391904001639	ATP binding site [chemical binding]; other site
391904001640	Q-loop/lid; other site
391904001641	ABC transporter signature motif; other site
391904001642	Walker B; other site
391904001643	D-loop; other site
391904001644	H-loop/switch region; other site
391904001645	ABC transporter; Region: ABC_tran_2; pfam12848
391904001646	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904001647	Transposase, Mutator family; Region: Transposase_mut; pfam00872
391904001648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001649	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904001650	putative substrate translocation pore; other site
391904001651	Transposase, Mutator family; Region: Transposase_mut; pfam00872
391904001652	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904001653	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904001654	Walker A/P-loop; other site
391904001655	ATP binding site [chemical binding]; other site
391904001656	Q-loop/lid; other site
391904001657	ABC transporter signature motif; other site
391904001658	Walker B; other site
391904001659	D-loop; other site
391904001660	H-loop/switch region; other site
391904001661	FtsX-like permease family; Region: FtsX; pfam02687
391904001662	Predicted transcriptional regulators [Transcription]; Region: COG1695
391904001663	Transcriptional regulator PadR-like family; Region: PadR; cl17335
391904001664	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
391904001665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001666	putative substrate translocation pore; other site
391904001667	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
391904001668	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904001669	nucleotide binding site [chemical binding]; other site
391904001670	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
391904001671	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904001672	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
391904001673	active site
391904001674	catalytic tetrad [active]
391904001675	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
391904001676	active site
391904001677	catalytic residues [active]
391904001678	metal binding site [ion binding]; metal-binding site
391904001679	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
391904001680	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
391904001681	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904001682	nucleotide binding site [chemical binding]; other site
391904001683	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904001684	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904001685	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
391904001686	peptide chain release factor 1; Validated; Region: prfA; PRK00591
391904001687	This domain is found in peptide chain release factors; Region: PCRF; smart00937
391904001688	RF-1 domain; Region: RF-1; pfam00472
391904001689	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
391904001690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904001691	S-adenosylmethionine binding site [chemical binding]; other site
391904001692	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
391904001693	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
391904001694	putative ligand binding site [chemical binding]; other site
391904001695	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
391904001696	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
391904001697	TM-ABC transporter signature motif; other site
391904001698	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
391904001699	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
391904001700	TM-ABC transporter signature motif; other site
391904001701	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
391904001702	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
391904001703	Walker A/P-loop; other site
391904001704	ATP binding site [chemical binding]; other site
391904001705	Q-loop/lid; other site
391904001706	ABC transporter signature motif; other site
391904001707	Walker B; other site
391904001708	D-loop; other site
391904001709	H-loop/switch region; other site
391904001710	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
391904001711	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
391904001712	Walker A/P-loop; other site
391904001713	ATP binding site [chemical binding]; other site
391904001714	Q-loop/lid; other site
391904001715	ABC transporter signature motif; other site
391904001716	Walker B; other site
391904001717	D-loop; other site
391904001718	H-loop/switch region; other site
391904001719	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
391904001720	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
391904001721	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
391904001722	Mg++ binding site [ion binding]; other site
391904001723	putative catalytic motif [active]
391904001724	substrate binding site [chemical binding]; other site
391904001725	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
391904001726	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
391904001727	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
391904001728	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
391904001729	active site
391904001730	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
391904001731	catalytic site [active]
391904001732	putative active site [active]
391904001733	putative substrate binding site [chemical binding]; other site
391904001734	dimer interface [polypeptide binding]; other site
391904001735	AAA domain; Region: AAA_30; pfam13604
391904001736	PIF1-like helicase; Region: PIF1; pfam05970
391904001737	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
391904001738	prolyl-tRNA synthetase; Provisional; Region: PRK09194
391904001739	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
391904001740	dimer interface [polypeptide binding]; other site
391904001741	motif 1; other site
391904001742	active site
391904001743	motif 2; other site
391904001744	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
391904001745	putative deacylase active site [active]
391904001746	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
391904001747	active site
391904001748	motif 3; other site
391904001749	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
391904001750	anticodon binding site; other site
391904001751	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
391904001752	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
391904001753	dimer interface [polypeptide binding]; other site
391904001754	ssDNA binding site [nucleotide binding]; other site
391904001755	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904001756	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
391904001757	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
391904001758	active site
391904001759	Zn binding site [ion binding]; other site
391904001760	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
391904001761	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
391904001762	active site
391904001763	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
391904001764	Citrate synthase; Region: Citrate_synt; pfam00285
391904001765	oxalacetate binding site [chemical binding]; other site
391904001766	citrylCoA binding site [chemical binding]; other site
391904001767	coenzyme A binding site [chemical binding]; other site
391904001768	catalytic triad [active]
391904001769	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
391904001770	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
391904001771	putative trimer interface [polypeptide binding]; other site
391904001772	putative CoA binding site [chemical binding]; other site
391904001773	WYL domain; Region: WYL; pfam13280
391904001774	SWIM zinc finger; Region: SWIM; pfam04434
391904001775	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
391904001776	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
391904001777	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904001778	ATP binding site [chemical binding]; other site
391904001779	putative Mg++ binding site [ion binding]; other site
391904001780	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904001781	nucleotide binding region [chemical binding]; other site
391904001782	ATP-binding site [chemical binding]; other site
391904001783	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
391904001784	additional DNA contacts [nucleotide binding]; other site
391904001785	mismatch recognition site; other site
391904001786	active site
391904001787	zinc binding site [ion binding]; other site
391904001788	DNA intercalation site [nucleotide binding]; other site
391904001789	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
391904001790	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
391904001791	hypothetical protein; Provisional; Region: PRK08960
391904001792	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904001793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904001794	homodimer interface [polypeptide binding]; other site
391904001795	catalytic residue [active]
391904001796	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
391904001797	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
391904001798	putative catalytic site [active]
391904001799	putative metal binding site [ion binding]; other site
391904001800	putative phosphate binding site [ion binding]; other site
391904001801	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
391904001802	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
391904001803	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
391904001804	acyl-activating enzyme (AAE) consensus motif; other site
391904001805	putative AMP binding site [chemical binding]; other site
391904001806	putative active site [active]
391904001807	putative CoA binding site [chemical binding]; other site
391904001808	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
391904001809	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
391904001810	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
391904001811	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
391904001812	generic binding surface II; other site
391904001813	generic binding surface I; other site
391904001814	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
391904001815	ATP cone domain; Region: ATP-cone; pfam03477
391904001816	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
391904001817	Class III ribonucleotide reductase; Region: RNR_III; cd01675
391904001818	active site
391904001819	Zn binding site [ion binding]; other site
391904001820	glycine loop; other site
391904001821	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
391904001822	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
391904001823	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
391904001824	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
391904001825	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
391904001826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
391904001827	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
391904001828	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
391904001829	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
391904001830	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
391904001831	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
391904001832	catalytic residues [active]
391904001833	catalytic nucleophile [active]
391904001834	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
391904001835	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
391904001836	Probable transposase; Region: OrfB_IS605; pfam01385
391904001837	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
391904001838	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
391904001839	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
391904001840	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
391904001841	active site
391904001842	NTP binding site [chemical binding]; other site
391904001843	metal binding triad [ion binding]; metal-binding site
391904001844	antibiotic binding site [chemical binding]; other site
391904001845	nucleotidyltransferase substrate binding protein, HI0074 family; Region: HI0074; TIGR01987
391904001846	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
391904001847	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904001848	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904001849	Winged helix-turn helix; Region: HTH_29; pfam13551
391904001850	putative transposase OrfB; Reviewed; Region: PHA02517
391904001851	HTH-like domain; Region: HTH_21; pfam13276
391904001852	Integrase core domain; Region: rve; pfam00665
391904001853	Integrase core domain; Region: rve_2; pfam13333
391904001854	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
391904001855	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904001856	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
391904001857	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
391904001858	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
391904001859	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
391904001860	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
391904001861	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391904001862	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
391904001863	GAF domain; Region: GAF_3; pfam13492
391904001864	Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960
391904001865	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924
391904001866	NodB motif; other site
391904001867	putative active site [active]
391904001868	putative catalytic site [active]
391904001869	putative Zn binding site [ion binding]; other site
391904001870	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
391904001871	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391904001872	Predicted membrane protein [Function unknown]; Region: COG4267
391904001873	CotH protein; Region: CotH; pfam08757
391904001874	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
391904001875	putative metal binding residues [ion binding]; other site
391904001876	signature motif; other site
391904001877	dimer interface [polypeptide binding]; other site
391904001878	active site
391904001879	polyP binding site; other site
391904001880	substrate binding site [chemical binding]; other site
391904001881	acceptor-phosphate pocket; other site
391904001882	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
391904001883	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
391904001884	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
391904001885	metal binding site [ion binding]; metal-binding site
391904001886	active site
391904001887	I-site; other site
391904001888	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904001889	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904001890	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001891	Walker A/P-loop; other site
391904001892	ATP binding site [chemical binding]; other site
391904001893	Q-loop/lid; other site
391904001894	ABC transporter signature motif; other site
391904001895	Walker B; other site
391904001896	D-loop; other site
391904001897	H-loop/switch region; other site
391904001898	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904001899	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904001900	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
391904001901	Walker A/P-loop; other site
391904001902	ATP binding site [chemical binding]; other site
391904001903	Q-loop/lid; other site
391904001904	ABC transporter signature motif; other site
391904001905	Walker B; other site
391904001906	D-loop; other site
391904001907	H-loop/switch region; other site
391904001908	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001909	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904001910	DNA binding site [nucleotide binding]
391904001911	domain linker motif; other site
391904001912	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904001913	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
391904001914	active site
391904001915	tetramer interface [polypeptide binding]; other site
391904001916	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
391904001917	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001918	putative substrate translocation pore; other site
391904001919	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
391904001920	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
391904001921	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
391904001922	substrate binding site [chemical binding]; other site
391904001923	dimer interface [polypeptide binding]; other site
391904001924	ATP binding site [chemical binding]; other site
391904001925	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001926	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904001927	DNA binding site [nucleotide binding]
391904001928	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
391904001929	putative dimerization interface [polypeptide binding]; other site
391904001930	putative ligand binding site [chemical binding]; other site
391904001931	Transcriptional regulators [Transcription]; Region: FadR; COG2186
391904001932	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
391904001933	DNA-binding site [nucleotide binding]; DNA binding site
391904001934	FCD domain; Region: FCD; pfam07729
391904001935	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904001936	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904001937	nucleotide binding site [chemical binding]; other site
391904001938	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
391904001939	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
391904001940	putative active site cavity [active]
391904001941	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
391904001942	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
391904001943	catalytic site [active]
391904001944	Asp-box motif; other site
391904001945	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
391904001946	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
391904001947	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904001948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001949	dimer interface [polypeptide binding]; other site
391904001950	conserved gate region; other site
391904001951	putative PBP binding loops; other site
391904001952	ABC-ATPase subunit interface; other site
391904001953	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
391904001954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001955	dimer interface [polypeptide binding]; other site
391904001956	conserved gate region; other site
391904001957	putative PBP binding loops; other site
391904001958	ABC-ATPase subunit interface; other site
391904001959	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
391904001960	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904001961	Walker A/P-loop; other site
391904001962	ATP binding site [chemical binding]; other site
391904001963	Q-loop/lid; other site
391904001964	ABC transporter signature motif; other site
391904001965	Walker B; other site
391904001966	D-loop; other site
391904001967	H-loop/switch region; other site
391904001968	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
391904001969	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
391904001970	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904001971	Walker A/P-loop; other site
391904001972	ATP binding site [chemical binding]; other site
391904001973	Q-loop/lid; other site
391904001974	ABC transporter signature motif; other site
391904001975	Walker B; other site
391904001976	D-loop; other site
391904001977	H-loop/switch region; other site
391904001978	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904001979	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
391904001980	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
391904001981	inhibitor site; inhibition site
391904001982	active site
391904001983	dimer interface [polypeptide binding]; other site
391904001984	catalytic residue [active]
391904001985	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
391904001986	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904001987	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904001988	homodimer interface [polypeptide binding]; other site
391904001989	catalytic residue [active]
391904001990	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
391904001991	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
391904001992	HIGH motif; other site
391904001993	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
391904001994	active site
391904001995	KMSKS motif; other site
391904001996	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
391904001997	tRNA binding surface [nucleotide binding]; other site
391904001998	anticodon binding site; other site
391904001999	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002000	dimer interface [polypeptide binding]; other site
391904002001	conserved gate region; other site
391904002002	putative PBP binding loops; other site
391904002003	ABC-ATPase subunit interface; other site
391904002004	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
391904002005	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904002006	Walker A/P-loop; other site
391904002007	ATP binding site [chemical binding]; other site
391904002008	Q-loop/lid; other site
391904002009	ABC transporter signature motif; other site
391904002010	Walker B; other site
391904002011	D-loop; other site
391904002012	H-loop/switch region; other site
391904002013	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
391904002014	Transposase, Mutator family; Region: Transposase_mut; pfam00872
391904002015	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904002016	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
391904002017	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
391904002018	potential frameshift: common BLAST hit: gi|296455018|ref|YP_003662162.1| Na-galactoside symporter
391904002019	MFS/sugar transport protein; Region: MFS_2; pfam13347
391904002020	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904002021	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904002022	DNA binding site [nucleotide binding]
391904002023	domain linker motif; other site
391904002024	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904002025	dimerization interface [polypeptide binding]; other site
391904002026	ligand binding site [chemical binding]; other site
391904002027	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904002028	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904002029	DNA binding site [nucleotide binding]
391904002030	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904002031	dimerization interface [polypeptide binding]; other site
391904002032	ligand binding site [chemical binding]; other site
391904002033	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
391904002034	AAA domain; Region: AAA_33; pfam13671
391904002035	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
391904002036	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
391904002037	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
391904002038	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
391904002039	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
391904002040	metal binding site [ion binding]; metal-binding site
391904002041	substrate binding pocket [chemical binding]; other site
391904002042	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
391904002043	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
391904002044	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
391904002045	glucuronate isomerase; Reviewed; Region: PRK02925
391904002046	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
391904002047	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
391904002048	nucleotide binding site/active site [active]
391904002049	HIT family signature motif; other site
391904002050	catalytic residue [active]
391904002051	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904002052	Transposase; Region: HTH_Tnp_1; pfam01527
391904002053	Integrase core domain; Region: rve; pfam00665
391904002054	Integrase core domain; Region: rve_3; pfam13683
391904002055	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
391904002056	Fusaric acid resistance protein family; Region: FUSC; pfam04632
391904002057	transposase/IS protein; Provisional; Region: PRK09183
391904002058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904002059	Walker A motif; other site
391904002060	ATP binding site [chemical binding]; other site
391904002061	Walker B motif; other site
391904002062	Low molecular weight phosphatase family; Region: LMWPc; cl00105
391904002063	active site
391904002064	potential frameshift: common BLAST hit: gi|322690986|ref|YP_004220556.1| transposase
391904002065	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
391904002066	IHF dimer interface [polypeptide binding]; other site
391904002067	IHF - DNA interface [nucleotide binding]; other site
391904002068	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
391904002069	adenylosuccinate lyase; Provisional; Region: PRK09285
391904002070	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
391904002071	tetramer interface [polypeptide binding]; other site
391904002072	active site
391904002073	PGAP1-like protein; Region: PGAP1; pfam07819
391904002074	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
391904002075	metal ion-dependent adhesion site (MIDAS); other site
391904002076	von Willebrand factor type A domain; Region: VWA_2; pfam13519
391904002077	Protein of unknown function DUF58; Region: DUF58; pfam01882
391904002078	MoxR-like ATPases [General function prediction only]; Region: COG0714
391904002079	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
391904002080	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
391904002081	ligand binding site [chemical binding]; other site
391904002082	active site
391904002083	UGI interface [polypeptide binding]; other site
391904002084	catalytic site [active]
391904002085	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
391904002086	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
391904002087	DNA-binding site [nucleotide binding]; DNA binding site
391904002088	RNA-binding motif; other site
391904002089	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
391904002090	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
391904002091	ring oligomerisation interface [polypeptide binding]; other site
391904002092	ATP/Mg binding site [chemical binding]; other site
391904002093	stacking interactions; other site
391904002094	hinge regions; other site
391904002095	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
391904002096	Repair protein; Region: Repair_PSII; cl01535
391904002097	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904002098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904002099	active site
391904002100	phosphorylation site [posttranslational modification]
391904002101	intermolecular recognition site; other site
391904002102	dimerization interface [polypeptide binding]; other site
391904002103	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391904002104	DNA binding site [nucleotide binding]
391904002105	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391904002106	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
391904002107	dimerization interface [polypeptide binding]; other site
391904002108	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391904002109	dimer interface [polypeptide binding]; other site
391904002110	phosphorylation site [posttranslational modification]
391904002111	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904002112	ATP binding site [chemical binding]; other site
391904002113	Mg2+ binding site [ion binding]; other site
391904002114	G-X-G motif; other site
391904002115	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
391904002116	DNA-binding site [nucleotide binding]; DNA binding site
391904002117	RNA-binding motif; other site
391904002118	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
391904002119	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
391904002120	Ligand Binding Site [chemical binding]; other site
391904002121	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
391904002122	Ligand Binding Site [chemical binding]; other site
391904002123	Clp protease ATP binding subunit; Region: clpC; CHL00095
391904002124	Clp amino terminal domain; Region: Clp_N; pfam02861
391904002125	Clp amino terminal domain; Region: Clp_N; pfam02861
391904002126	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904002127	Walker A motif; other site
391904002128	ATP binding site [chemical binding]; other site
391904002129	Walker B motif; other site
391904002130	arginine finger; other site
391904002131	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904002132	Walker A motif; other site
391904002133	ATP binding site [chemical binding]; other site
391904002134	Walker B motif; other site
391904002135	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
391904002136	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
391904002137	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
391904002138	active site
391904002139	metal binding site [ion binding]; metal-binding site
391904002140	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
391904002141	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
391904002142	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
391904002143	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
391904002144	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
391904002145	dimer interface [polypeptide binding]; other site
391904002146	motif 1; other site
391904002147	active site
391904002148	motif 2; other site
391904002149	motif 3; other site
391904002150	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
391904002151	anticodon binding site; other site
391904002152	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
391904002153	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
391904002154	dimer interface [polypeptide binding]; other site
391904002155	anticodon binding site; other site
391904002156	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
391904002157	motif 1; other site
391904002158	dimer interface [polypeptide binding]; other site
391904002159	active site
391904002160	motif 2; other site
391904002161	GAD domain; Region: GAD; pfam02938
391904002162	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
391904002163	active site
391904002164	motif 3; other site
391904002165	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391904002166	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
391904002167	Walker A/P-loop; other site
391904002168	ATP binding site [chemical binding]; other site
391904002169	Q-loop/lid; other site
391904002170	ABC transporter signature motif; other site
391904002171	Walker B; other site
391904002172	D-loop; other site
391904002173	H-loop/switch region; other site
391904002174	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904002175	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391904002176	substrate binding pocket [chemical binding]; other site
391904002177	membrane-bound complex binding site; other site
391904002178	hinge residues; other site
391904002179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002180	dimer interface [polypeptide binding]; other site
391904002181	conserved gate region; other site
391904002182	ABC-ATPase subunit interface; other site
391904002183	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002184	dimer interface [polypeptide binding]; other site
391904002185	conserved gate region; other site
391904002186	putative PBP binding loops; other site
391904002187	ABC-ATPase subunit interface; other site
391904002188	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
391904002189	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
391904002190	active site
391904002191	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
391904002192	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904002193	ATP binding site [chemical binding]; other site
391904002194	putative Mg++ binding site [ion binding]; other site
391904002195	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904002196	nucleotide binding region [chemical binding]; other site
391904002197	ATP-binding site [chemical binding]; other site
391904002198	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
391904002199	recombination factor protein RarA; Reviewed; Region: PRK13342
391904002200	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904002201	Walker A motif; other site
391904002202	ATP binding site [chemical binding]; other site
391904002203	Walker B motif; other site
391904002204	arginine finger; other site
391904002205	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
391904002206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904002207	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
391904002208	putative substrate translocation pore; other site
391904002209	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
391904002210	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
391904002211	NAD binding site [chemical binding]; other site
391904002212	ligand binding site [chemical binding]; other site
391904002213	catalytic site [active]
391904002214	Membrane protein of unknown function; Region: DUF360; pfam04020
391904002215	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
391904002216	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
391904002217	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
391904002218	Walker A/P-loop; other site
391904002219	ATP binding site [chemical binding]; other site
391904002220	Q-loop/lid; other site
391904002221	ABC transporter signature motif; other site
391904002222	Walker B; other site
391904002223	D-loop; other site
391904002224	H-loop/switch region; other site
391904002225	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
391904002226	Walker A/P-loop; other site
391904002227	ATP binding site [chemical binding]; other site
391904002228	Q-loop/lid; other site
391904002229	ABC transporter signature motif; other site
391904002230	Walker B; other site
391904002231	D-loop; other site
391904002232	H-loop/switch region; other site
391904002233	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
391904002234	Predicted membrane protein [Function unknown]; Region: COG3601
391904002235	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
391904002236	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391904002237	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
391904002238	Probable Catalytic site; other site
391904002239	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904002240	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904002241	nucleotide binding site [chemical binding]; other site
391904002242	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904002243	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904002244	homodimer interface [polypeptide binding]; other site
391904002245	catalytic residue [active]
391904002246	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904002247	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
391904002248	Walker A/P-loop; other site
391904002249	ATP binding site [chemical binding]; other site
391904002250	ABC transporter signature motif; other site
391904002251	Walker B; other site
391904002252	D-loop; other site
391904002253	H-loop/switch region; other site
391904002254	TPR repeat; Region: TPR_11; pfam13414
391904002255	Ligase N family; Region: LIGANc; smart00532
391904002256	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
391904002257	nucleotide binding pocket [chemical binding]; other site
391904002258	K-X-D-G motif; other site
391904002259	catalytic site [active]
391904002260	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
391904002261	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
391904002262	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
391904002263	helix-hairpin-helix signature motif; other site
391904002264	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
391904002265	Dimer interface [polypeptide binding]; other site
391904002266	Domain of unknown function DUF59; Region: DUF59; cl00941
391904002267	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
391904002268	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
391904002269	Walker A motif; other site
391904002270	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
391904002271	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
391904002272	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
391904002273	putative active site [active]
391904002274	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
391904002275	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904002276	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904002277	Walker A/P-loop; other site
391904002278	ATP binding site [chemical binding]; other site
391904002279	Q-loop/lid; other site
391904002280	ABC transporter signature motif; other site
391904002281	Walker B; other site
391904002282	D-loop; other site
391904002283	H-loop/switch region; other site
391904002284	elongation factor P; Validated; Region: PRK00529
391904002285	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
391904002286	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
391904002287	RNA binding site [nucleotide binding]; other site
391904002288	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
391904002289	RNA binding site [nucleotide binding]; other site
391904002290	transcription antitermination factor NusB; Region: nusB; TIGR01951
391904002291	putative RNA binding site [nucleotide binding]; other site
391904002292	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
391904002293	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
391904002294	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
391904002295	catalytic site [active]
391904002296	subunit interface [polypeptide binding]; other site
391904002297	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
391904002298	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
391904002299	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391904002300	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
391904002301	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
391904002302	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391904002303	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
391904002304	IMP binding site; other site
391904002305	dimer interface [polypeptide binding]; other site
391904002306	interdomain contacts; other site
391904002307	partial ornithine binding site; other site
391904002308	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
391904002309	active site
391904002310	dimer interface [polypeptide binding]; other site
391904002311	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
391904002312	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
391904002313	catalytic site [active]
391904002314	G-X2-G-X-G-K; other site
391904002315	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
391904002316	active site
391904002317	catalytic site [active]
391904002318	substrate binding site [chemical binding]; other site
391904002319	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
391904002320	translation elongation factor EF-G; Region: EF-G; TIGR00484
391904002321	G1 box; other site
391904002322	putative GEF interaction site [polypeptide binding]; other site
391904002323	GTP/Mg2+ binding site [chemical binding]; other site
391904002324	Switch I region; other site
391904002325	G2 box; other site
391904002326	G3 box; other site
391904002327	Switch II region; other site
391904002328	G4 box; other site
391904002329	G5 box; other site
391904002330	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
391904002331	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
391904002332	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
391904002333	Predicted esterase [General function prediction only]; Region: COG0400
391904002334	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391904002335	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
391904002336	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002337	dimer interface [polypeptide binding]; other site
391904002338	conserved gate region; other site
391904002339	putative PBP binding loops; other site
391904002340	ABC-ATPase subunit interface; other site
391904002341	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
391904002342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002343	dimer interface [polypeptide binding]; other site
391904002344	conserved gate region; other site
391904002345	putative PBP binding loops; other site
391904002346	ABC-ATPase subunit interface; other site
391904002347	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
391904002348	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391904002349	Walker A/P-loop; other site
391904002350	ATP binding site [chemical binding]; other site
391904002351	Q-loop/lid; other site
391904002352	ABC transporter signature motif; other site
391904002353	Walker B; other site
391904002354	D-loop; other site
391904002355	H-loop/switch region; other site
391904002356	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
391904002357	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904002358	substrate binding pocket [chemical binding]; other site
391904002359	membrane-bound complex binding site; other site
391904002360	hinge residues; other site
391904002361	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
391904002362	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
391904002363	homodimer interface [polypeptide binding]; other site
391904002364	substrate-cofactor binding pocket; other site
391904002365	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904002366	catalytic residue [active]
391904002367	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
391904002368	catalytic residues [active]
391904002369	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
391904002370	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
391904002371	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
391904002372	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
391904002373	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
391904002374	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904002375	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
391904002376	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
391904002377	TM-ABC transporter signature motif; other site
391904002378	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
391904002379	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
391904002380	TM-ABC transporter signature motif; other site
391904002381	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
391904002382	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
391904002383	Walker A/P-loop; other site
391904002384	ATP binding site [chemical binding]; other site
391904002385	Q-loop/lid; other site
391904002386	ABC transporter signature motif; other site
391904002387	Walker B; other site
391904002388	D-loop; other site
391904002389	H-loop/switch region; other site
391904002390	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
391904002391	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
391904002392	Walker A/P-loop; other site
391904002393	ATP binding site [chemical binding]; other site
391904002394	Q-loop/lid; other site
391904002395	ABC transporter signature motif; other site
391904002396	Walker B; other site
391904002397	D-loop; other site
391904002398	H-loop/switch region; other site
391904002399	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
391904002400	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
391904002401	metal binding site [ion binding]; metal-binding site
391904002402	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
391904002403	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
391904002404	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904002405	catalytic residue [active]
391904002406	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
391904002407	catalytic residues [active]
391904002408	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391904002409	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
391904002410	Walker A/P-loop; other site
391904002411	ATP binding site [chemical binding]; other site
391904002412	Q-loop/lid; other site
391904002413	ABC transporter signature motif; other site
391904002414	Walker B; other site
391904002415	D-loop; other site
391904002416	H-loop/switch region; other site
391904002417	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391904002418	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904002419	substrate binding pocket [chemical binding]; other site
391904002420	membrane-bound complex binding site; other site
391904002421	hinge residues; other site
391904002422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002423	dimer interface [polypeptide binding]; other site
391904002424	conserved gate region; other site
391904002425	putative PBP binding loops; other site
391904002426	ABC-ATPase subunit interface; other site
391904002427	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
391904002428	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
391904002429	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904002430	Integrase core domain; Region: rve; pfam00665
391904002431	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904002432	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904002433	Walker A/P-loop; other site
391904002434	ATP binding site [chemical binding]; other site
391904002435	Q-loop/lid; other site
391904002436	ABC transporter signature motif; other site
391904002437	Walker B; other site
391904002438	D-loop; other site
391904002439	H-loop/switch region; other site
391904002440	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
391904002441	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
391904002442	active site
391904002443	nucleophile elbow; other site
391904002444	glutamate racemase; Provisional; Region: PRK00865
391904002445	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
391904002446	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
391904002447	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
391904002448	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
391904002449	putative active site [active]
391904002450	redox center [active]
391904002451	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
391904002452	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
391904002453	active site
391904002454	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
391904002455	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
391904002456	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
391904002457	substrate binding site [chemical binding]; other site
391904002458	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
391904002459	Part of AAA domain; Region: AAA_19; pfam13245
391904002460	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
391904002461	Family description; Region: UvrD_C_2; pfam13538
391904002462	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
391904002463	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
391904002464	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
391904002465	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
391904002466	DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543
391904002467	DivIVA domain; Region: DivI1A_domain; TIGR03544
391904002468	DivIVA domain; Region: DivI1A_domain; TIGR03544
391904002469	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
391904002470	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
391904002471	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
391904002472	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
391904002473	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
391904002474	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
391904002475	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
391904002476	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
391904002477	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
391904002478	Recombination protein O N terminal; Region: RecO_N; pfam11967
391904002479	Recombination protein O C terminal; Region: RecO_C; pfam02565
391904002480	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829
391904002481	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
391904002482	catalytic residue [active]
391904002483	putative FPP diphosphate  binding site; other site
391904002484	putative FPP binding hydrophobic cleft; other site
391904002485	dimer interface [polypeptide binding]; other site
391904002486	putative IPP diphosphate binding site; other site
391904002487	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
391904002488	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
391904002489	active site
391904002490	NMT1/THI5 like; Region: NMT1; pfam09084
391904002491	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
391904002492	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002493	dimer interface [polypeptide binding]; other site
391904002494	conserved gate region; other site
391904002495	putative PBP binding loops; other site
391904002496	ABC-ATPase subunit interface; other site
391904002497	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
391904002498	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
391904002499	substrate binding [chemical binding]; other site
391904002500	active site
391904002501	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
391904002502	galactoside permease; Reviewed; Region: lacY; PRK09528
391904002503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904002504	putative substrate translocation pore; other site
391904002505	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904002506	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904002507	DNA binding site [nucleotide binding]
391904002508	domain linker motif; other site
391904002509	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
391904002510	putative dimerization interface [polypeptide binding]; other site
391904002511	putative ligand binding site [chemical binding]; other site
391904002512	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172
391904002513	serpin-like protein; Provisional; Region: PHA02660
391904002514	reactive center loop; other site
391904002515	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904002516	Domain of unknown function DUF77; Region: DUF77; pfam01910
391904002517	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
391904002518	substrate binding site [chemical binding]; other site
391904002519	dimer interface [polypeptide binding]; other site
391904002520	ATP binding site [chemical binding]; other site
391904002521	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904002522	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
391904002523	Walker A motif; other site
391904002524	ATP binding site [chemical binding]; other site
391904002525	Walker B motif; other site
391904002526	arginine finger; other site
391904002527	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
391904002528	thiamine phosphate binding site [chemical binding]; other site
391904002529	active site
391904002530	pyrophosphate binding site [ion binding]; other site
391904002531	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
391904002532	ThiC-associated domain; Region: ThiC-associated; pfam13667
391904002533	ThiC family; Region: ThiC; pfam01964
391904002534	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
391904002535	substrate binding site [chemical binding]; other site
391904002536	multimerization interface [polypeptide binding]; other site
391904002537	ATP binding site [chemical binding]; other site
391904002538	glycyl-tRNA synthetase; Provisional; Region: PRK04173
391904002539	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
391904002540	motif 1; other site
391904002541	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
391904002542	active site
391904002543	motif 2; other site
391904002544	motif 3; other site
391904002545	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
391904002546	anticodon binding site; other site
391904002547	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
391904002548	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
391904002549	FMN binding site [chemical binding]; other site
391904002550	active site
391904002551	catalytic residues [active]
391904002552	substrate binding site [chemical binding]; other site
391904002553	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
391904002554	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
391904002555	nucleotide binding site [chemical binding]; other site
391904002556	SulA interaction site; other site
391904002557	Protein of unknown function (DUF552); Region: DUF552; pfam04472
391904002558	YGGT family; Region: YGGT; pfam02325
391904002559	DivIVA protein; Region: DivIVA; pfam05103
391904002560	DivIVA domain; Region: DivI1A_domain; TIGR03544
391904002561	lipoprotein signal peptidase; Provisional; Region: PRK14771
391904002562	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
391904002563	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
391904002564	active site
391904002565	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
391904002566	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
391904002567	Predicted transcriptional regulator [Transcription]; Region: COG2378
391904002568	putative DNA binding site [nucleotide binding]; other site
391904002569	putative Zn2+ binding site [ion binding]; other site
391904002570	WYL domain; Region: WYL; pfam13280
391904002571	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
391904002572	PHP domain; Region: PHP; pfam02811
391904002573	active site
391904002574	PHP Thumb interface [polypeptide binding]; other site
391904002575	metal binding site [ion binding]; metal-binding site
391904002576	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
391904002577	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
391904002578	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904002579	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
391904002580	Family description; Region: UvrD_C_2; pfam13538
391904002581	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
391904002582	Protein of unknown function DUF262; Region: DUF262; pfam03235
391904002583	Uncharacterized conserved protein [Function unknown]; Region: COG1479
391904002584	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
391904002585	Uncharacterized conserved protein [Function unknown]; Region: COG1479
391904002586	Protein of unknown function DUF262; Region: DUF262; pfam03235
391904002587	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
391904002588	Transposase; Region: DDE_Tnp_ISL3; pfam01610
391904002589	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
391904002590	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
391904002591	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
391904002592	active site
391904002593	PHP Thumb interface [polypeptide binding]; other site
391904002594	metal binding site [ion binding]; metal-binding site
391904002595	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
391904002596	generic binding surface II; other site
391904002597	generic binding surface I; other site
391904002598	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
391904002599	myosin-cross-reactive antigen; Provisional; Region: PRK13977
391904002600	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904002601	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
391904002602	active site
391904002603	catalytic tetrad [active]
391904002604	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
391904002605	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805
391904002606	N- and C-terminal domain interface [polypeptide binding]; other site
391904002607	active site
391904002608	MgATP binding site [chemical binding]; other site
391904002609	catalytic site [active]
391904002610	metal binding site [ion binding]; metal-binding site
391904002611	xylulose binding site [chemical binding]; other site
391904002612	putative homodimer interface [polypeptide binding]; other site
391904002613	acylphosphatase; Provisional; Region: PRK14428
391904002614	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
391904002615	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
391904002616	NAD binding site [chemical binding]; other site
391904002617	dimerization interface [polypeptide binding]; other site
391904002618	product binding site; other site
391904002619	substrate binding site [chemical binding]; other site
391904002620	zinc binding site [ion binding]; other site
391904002621	catalytic residues [active]
391904002622	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
391904002623	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904002624	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904002625	homodimer interface [polypeptide binding]; other site
391904002626	catalytic residue [active]
391904002627	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
391904002628	putative active site pocket [active]
391904002629	4-fold oligomerization interface [polypeptide binding]; other site
391904002630	metal binding residues [ion binding]; metal-binding site
391904002631	3-fold/trimer interface [polypeptide binding]; other site
391904002632	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
391904002633	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
391904002634	putative active site [active]
391904002635	oxyanion strand; other site
391904002636	catalytic triad [active]
391904002637	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
391904002638	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
391904002639	catalytic residues [active]
391904002640	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
391904002641	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
391904002642	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
391904002643	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
391904002644	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
391904002645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904002646	putative substrate translocation pore; other site
391904002647	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904002648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002649	dimer interface [polypeptide binding]; other site
391904002650	conserved gate region; other site
391904002651	putative PBP binding loops; other site
391904002652	ABC-ATPase subunit interface; other site
391904002653	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904002654	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002655	dimer interface [polypeptide binding]; other site
391904002656	conserved gate region; other site
391904002657	ABC-ATPase subunit interface; other site
391904002658	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
391904002659	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
391904002660	peptide binding site [polypeptide binding]; other site
391904002661	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
391904002662	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904002663	Walker A/P-loop; other site
391904002664	ATP binding site [chemical binding]; other site
391904002665	Q-loop/lid; other site
391904002666	ABC transporter signature motif; other site
391904002667	Walker B; other site
391904002668	D-loop; other site
391904002669	H-loop/switch region; other site
391904002670	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904002671	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904002672	Walker A/P-loop; other site
391904002673	ATP binding site [chemical binding]; other site
391904002674	Q-loop/lid; other site
391904002675	ABC transporter signature motif; other site
391904002676	Walker B; other site
391904002677	D-loop; other site
391904002678	H-loop/switch region; other site
391904002679	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904002680	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
391904002681	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904002682	ATP binding site [chemical binding]; other site
391904002683	putative Mg++ binding site [ion binding]; other site
391904002684	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904002685	nucleotide binding region [chemical binding]; other site
391904002686	ATP-binding site [chemical binding]; other site
391904002687	Helicase associated domain (HA2); Region: HA2; pfam04408
391904002688	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
391904002689	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
391904002690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904002691	S-adenosylmethionine binding site [chemical binding]; other site
391904002692	GTPases [General function prediction only]; Region: HflX; COG2262
391904002693	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
391904002694	HflX GTPase family; Region: HflX; cd01878
391904002695	G1 box; other site
391904002696	GTP/Mg2+ binding site [chemical binding]; other site
391904002697	Switch I region; other site
391904002698	G2 box; other site
391904002699	G3 box; other site
391904002700	Switch II region; other site
391904002701	G4 box; other site
391904002702	G5 box; other site
391904002703	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
391904002704	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
391904002705	NAD binding site [chemical binding]; other site
391904002706	dimer interface [polypeptide binding]; other site
391904002707	substrate binding site [chemical binding]; other site
391904002708	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904002709	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
391904002710	LexA repressor; Validated; Region: PRK00215
391904002711	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
391904002712	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
391904002713	Catalytic site [active]
391904002714	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
391904002715	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
391904002716	ATP cone domain; Region: ATP-cone; pfam03477
391904002717	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
391904002718	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
391904002719	ligand binding site [chemical binding]; other site
391904002720	NAD binding site [chemical binding]; other site
391904002721	tetramer interface [polypeptide binding]; other site
391904002722	catalytic site [active]
391904002723	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
391904002724	L-serine binding site [chemical binding]; other site
391904002725	ACT domain interface; other site
391904002726	Part of AAA domain; Region: AAA_19; pfam13245
391904002727	Family description; Region: UvrD_C_2; pfam13538
391904002728	cell division protein MraZ; Reviewed; Region: PRK00326
391904002729	MraZ protein; Region: MraZ; pfam02381
391904002730	MraZ protein; Region: MraZ; pfam02381
391904002731	MraW methylase family; Region: Methyltransf_5; cl17771
391904002732	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
391904002733	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
391904002734	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
391904002735	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
391904002736	putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929
391904002737	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
391904002738	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391904002739	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391904002740	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391904002741	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
391904002742	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
391904002743	Mg++ binding site [ion binding]; other site
391904002744	putative catalytic motif [active]
391904002745	putative substrate binding site [chemical binding]; other site
391904002746	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
391904002747	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
391904002748	NAD binding site [chemical binding]; other site
391904002749	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391904002750	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391904002751	cell division protein FtsW; Region: ftsW; TIGR02614
391904002752	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
391904002753	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
391904002754	active site
391904002755	homodimer interface [polypeptide binding]; other site
391904002756	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
391904002757	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391904002758	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391904002759	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391904002760	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
391904002761	Cell division protein FtsQ; Region: FtsQ; pfam03799
391904002762	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904002763	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391904002764	Walker A/P-loop; other site
391904002765	ATP binding site [chemical binding]; other site
391904002766	Q-loop/lid; other site
391904002767	ABC transporter signature motif; other site
391904002768	Walker B; other site
391904002769	D-loop; other site
391904002770	H-loop/switch region; other site
391904002771	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
391904002772	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904002773	Integrase core domain; Region: rve; pfam00665
391904002774	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
391904002775	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
391904002776	putative active site [active]
391904002777	dimerization interface [polypeptide binding]; other site
391904002778	putative tRNAtyr binding site [nucleotide binding]; other site
391904002779	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
391904002780	active site
391904002781	catalytic site [active]
391904002782	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
391904002783	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
391904002784	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
391904002785	active site
391904002786	catalytic site [active]
391904002787	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
391904002788	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
391904002789	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
391904002790	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
391904002791	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904002792	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002793	dimer interface [polypeptide binding]; other site
391904002794	conserved gate region; other site
391904002795	putative PBP binding loops; other site
391904002796	ABC-ATPase subunit interface; other site
391904002797	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904002798	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002799	dimer interface [polypeptide binding]; other site
391904002800	conserved gate region; other site
391904002801	ABC-ATPase subunit interface; other site
391904002802	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
391904002803	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904002804	Walker A/P-loop; other site
391904002805	ATP binding site [chemical binding]; other site
391904002806	Q-loop/lid; other site
391904002807	ABC transporter signature motif; other site
391904002808	Walker B; other site
391904002809	D-loop; other site
391904002810	H-loop/switch region; other site
391904002811	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904002812	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904002813	Walker A/P-loop; other site
391904002814	ATP binding site [chemical binding]; other site
391904002815	Q-loop/lid; other site
391904002816	ABC transporter signature motif; other site
391904002817	Walker B; other site
391904002818	D-loop; other site
391904002819	H-loop/switch region; other site
391904002820	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904002821	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904002822	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904002823	DNA binding site [nucleotide binding]
391904002824	domain linker motif; other site
391904002825	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904002826	ligand binding site [chemical binding]; other site
391904002827	dimerization interface [polypeptide binding]; other site
391904002828	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
391904002829	putative active cleft [active]
391904002830	Uncharacterized conserved protein [Function unknown]; Region: COG3538
391904002831	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
391904002832	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
391904002833	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
391904002834	putative substrate binding site [chemical binding]; other site
391904002835	putative ATP binding site [chemical binding]; other site
391904002836	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
391904002837	putative DNA binding site [nucleotide binding]; other site
391904002838	Transcriptional regulators [Transcription]; Region: MarR; COG1846
391904002839	putative Zn2+ binding site [ion binding]; other site
391904002840	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904002841	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904002842	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904002843	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904002844	nucleotide binding site [chemical binding]; other site
391904002845	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904002846	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904002847	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
391904002848	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
391904002849	active site
391904002850	trimer interface [polypeptide binding]; other site
391904002851	allosteric site; other site
391904002852	active site lid [active]
391904002853	hexamer (dimer of trimers) interface [polypeptide binding]; other site
391904002854	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
391904002855	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
391904002856	active site
391904002857	dimer interface [polypeptide binding]; other site
391904002858	carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850
391904002859	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
391904002860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002861	dimer interface [polypeptide binding]; other site
391904002862	conserved gate region; other site
391904002863	putative PBP binding loops; other site
391904002864	ABC-ATPase subunit interface; other site
391904002865	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904002866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002867	dimer interface [polypeptide binding]; other site
391904002868	conserved gate region; other site
391904002869	putative PBP binding loops; other site
391904002870	ABC-ATPase subunit interface; other site
391904002871	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
391904002872	nudix motif; other site
391904002873	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
391904002874	proline aminopeptidase P II; Provisional; Region: PRK10879
391904002875	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
391904002876	active site
391904002877	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
391904002878	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
391904002879	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391904002880	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391904002881	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
391904002882	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
391904002883	Walker A/P-loop; other site
391904002884	ATP binding site [chemical binding]; other site
391904002885	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
391904002886	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
391904002887	ABC transporter signature motif; other site
391904002888	Walker B; other site
391904002889	D-loop; other site
391904002890	H-loop/switch region; other site
391904002891	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
391904002892	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
391904002893	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391904002894	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391904002895	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391904002896	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
391904002897	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
391904002898	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
391904002899	DNA binding residues [nucleotide binding]
391904002900	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
391904002901	active site
391904002902	catalytic residues [active]
391904002903	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
391904002904	active site
391904002905	catalytic residues [active]
391904002906	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
391904002907	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
391904002908	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
391904002909	putative deacylase active site [active]
391904002910	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
391904002911	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
391904002912	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
391904002913	Thiamine pyrophosphokinase; Region: TPK; cd07995
391904002914	dimerization interface [polypeptide binding]; other site
391904002915	active site
391904002916	thiamine binding site [chemical binding]; other site
391904002917	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
391904002918	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
391904002919	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
391904002920	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
391904002921	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
391904002922	23S rRNA binding site [nucleotide binding]; other site
391904002923	L21 binding site [polypeptide binding]; other site
391904002924	L13 binding site [polypeptide binding]; other site
391904002925	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
391904002926	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
391904002927	active site
391904002928	Int/Topo IB signature motif; other site
391904002929	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
391904002930	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
391904002931	P-loop; other site
391904002932	Magnesium ion binding site [ion binding]; other site
391904002933	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
391904002934	Magnesium ion binding site [ion binding]; other site
391904002935	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
391904002936	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
391904002937	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
391904002938	nudix motif; other site
391904002939	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
391904002940	quinolinate synthetase; Provisional; Region: PRK09375
391904002941	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
391904002942	L-aspartate oxidase; Provisional; Region: PRK06175
391904002943	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
391904002944	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543
391904002945	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
391904002946	dimerization interface [polypeptide binding]; other site
391904002947	active site
391904002948	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
391904002949	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
391904002950	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904002951	catalytic residue [active]
391904002952	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
391904002953	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
391904002954	G1 box; other site
391904002955	putative GEF interaction site [polypeptide binding]; other site
391904002956	GTP/Mg2+ binding site [chemical binding]; other site
391904002957	Switch I region; other site
391904002958	G2 box; other site
391904002959	G3 box; other site
391904002960	Switch II region; other site
391904002961	G4 box; other site
391904002962	G5 box; other site
391904002963	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
391904002964	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
391904002965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904002966	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904002967	Homeodomain-like domain; Region: HTH_23; cl17451
391904002968	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
391904002969	Prephenate dehydratase; Region: PDT; pfam00800
391904002970	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
391904002971	putative L-Phe binding site [chemical binding]; other site
391904002972	Prephenate dehydrogenase; Region: PDH; pfam02153
391904002973	prephenate dehydrogenase; Validated; Region: PRK08507
391904002974	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
391904002975	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904002976	active site
391904002977	DNA binding site [nucleotide binding]
391904002978	Int/Topo IB signature motif; other site
391904002979	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
391904002980	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
391904002981	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904002982	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002983	dimer interface [polypeptide binding]; other site
391904002984	conserved gate region; other site
391904002985	putative PBP binding loops; other site
391904002986	ABC-ATPase subunit interface; other site
391904002987	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904002988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002989	dimer interface [polypeptide binding]; other site
391904002990	conserved gate region; other site
391904002991	putative PBP binding loops; other site
391904002992	ABC-ATPase subunit interface; other site
391904002993	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904002994	AAA domain; Region: AAA_21; pfam13304
391904002995	Walker A/P-loop; other site
391904002996	ATP binding site [chemical binding]; other site
391904002997	Q-loop/lid; other site
391904002998	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904002999	ABC transporter signature motif; other site
391904003000	Walker B; other site
391904003001	D-loop; other site
391904003002	H-loop/switch region; other site
391904003003	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904003004	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904003005	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
391904003006	Walker A/P-loop; other site
391904003007	ATP binding site [chemical binding]; other site
391904003008	Q-loop/lid; other site
391904003009	ABC transporter signature motif; other site
391904003010	Walker B; other site
391904003011	D-loop; other site
391904003012	H-loop/switch region; other site
391904003013	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904003014	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
391904003015	putative active site [active]
391904003016	putative catalytic site [active]
391904003017	putative DNA binding site [nucleotide binding]; other site
391904003018	putative phosphate binding site [ion binding]; other site
391904003019	metal binding site A [ion binding]; metal-binding site
391904003020	putative AP binding site [nucleotide binding]; other site
391904003021	putative metal binding site B [ion binding]; other site
391904003022	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
391904003023	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
391904003024	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
391904003025	TRAM domain; Region: TRAM; cl01282
391904003026	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904003027	S-adenosylmethionine binding site [chemical binding]; other site
391904003028	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
391904003029	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
391904003030	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904003031	motif II; other site
391904003032	aconitate hydratase; Validated; Region: PRK09277
391904003033	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
391904003034	substrate binding site [chemical binding]; other site
391904003035	ligand binding site [chemical binding]; other site
391904003036	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
391904003037	substrate binding site [chemical binding]; other site
391904003038	RelB antitoxin; Region: RelB; cl01171
391904003039	Protein of unknown function DUF262; Region: DUF262; pfam03235
391904003040	Uncharacterized conserved protein [Function unknown]; Region: COG1479
391904003041	Protein of unknown function DUF262; Region: DUF262; pfam03235
391904003042	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
391904003043	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904003044	Coenzyme A binding pocket [chemical binding]; other site
391904003045	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
391904003046	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
391904003047	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
391904003048	EamA-like transporter family; Region: EamA; pfam00892
391904003049	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
391904003050	synthetase active site [active]
391904003051	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391904003052	NTP binding site [chemical binding]; other site
391904003053	metal binding site [ion binding]; metal-binding site
391904003054	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
391904003055	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
391904003056	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391904003057	FeS/SAM binding site; other site
391904003058	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
391904003059	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
391904003060	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
391904003061	Fic/DOC family; Region: Fic; cl00960
391904003062	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
391904003063	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
391904003064	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
391904003065	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
391904003066	Competence-damaged protein; Region: CinA; pfam02464
391904003067	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904003068	sequence-specific DNA binding site [nucleotide binding]; other site
391904003069	salt bridge; other site
391904003070	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
391904003071	recombinase A; Provisional; Region: recA; PRK09354
391904003072	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
391904003073	hexamer interface [polypeptide binding]; other site
391904003074	Walker A motif; other site
391904003075	ATP binding site [chemical binding]; other site
391904003076	Walker B motif; other site
391904003077	RecX family; Region: RecX; pfam02631
391904003078	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
391904003079	30S subunit binding site; other site
391904003080	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
391904003081	DEAD/DEAH box helicase; Region: DEAD; pfam00270
391904003082	ATP binding site [chemical binding]; other site
391904003083	putative Mg++ binding site [ion binding]; other site
391904003084	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
391904003085	SEC-C motif; Region: SEC-C; pfam02810
391904003086	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
391904003087	active site
391904003088	catalytic triad [active]
391904003089	oxyanion hole [active]
391904003090	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
391904003091	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
391904003092	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
391904003093	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
391904003094	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
391904003095	putative acyl-acceptor binding pocket; other site
391904003096	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
391904003097	Catalytic domain of Protein Kinases; Region: PKc; cd00180
391904003098	active site
391904003099	ATP binding site [chemical binding]; other site
391904003100	substrate binding site [chemical binding]; other site
391904003101	activation loop (A-loop); other site
391904003102	PASTA domain; Region: PASTA; pfam03793
391904003103	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
391904003104	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
391904003105	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
391904003106	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
391904003107	substrate binding pocket [chemical binding]; other site
391904003108	chain length determination region; other site
391904003109	substrate-Mg2+ binding site; other site
391904003110	catalytic residues [active]
391904003111	aspartate-rich region 1; other site
391904003112	active site lid residues [active]
391904003113	aspartate-rich region 2; other site
391904003114	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
391904003115	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
391904003116	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
391904003117	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
391904003118	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
391904003119	DNA binding residues [nucleotide binding]
391904003120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904003121	Mg2+ binding site [ion binding]; other site
391904003122	G-X-G motif; other site
391904003123	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
391904003124	anchoring element; other site
391904003125	dimer interface [polypeptide binding]; other site
391904003126	ATP binding site [chemical binding]; other site
391904003127	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
391904003128	active site
391904003129	metal binding site [ion binding]; metal-binding site
391904003130	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
391904003131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904003132	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904003133	putative substrate translocation pore; other site
391904003134	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
391904003135	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
391904003136	substrate binding site [chemical binding]; other site
391904003137	dimer interface [polypeptide binding]; other site
391904003138	ATP binding site [chemical binding]; other site
391904003139	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904003140	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
391904003141	ATP binding site [chemical binding]; other site
391904003142	putative Mg++ binding site [ion binding]; other site
391904003143	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904003144	nucleotide binding region [chemical binding]; other site
391904003145	ATP-binding site [chemical binding]; other site
391904003146	DEAD/H associated; Region: DEAD_assoc; pfam08494
391904003147	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904003148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
391904003149	phosphorylation site [posttranslational modification]
391904003150	intermolecular recognition site; other site
391904003151	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
391904003152	DNA binding site [nucleotide binding]
391904003153	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
391904003154	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
391904003155	CAP-like domain; other site
391904003156	active site
391904003157	primary dimer interface [polypeptide binding]; other site
391904003158	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904003159	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
391904003160	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
391904003161	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
391904003162	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
391904003163	trimer interface [polypeptide binding]; other site
391904003164	active site
391904003165	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391904003166	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
391904003167	Zn2+ binding site [ion binding]; other site
391904003168	Mg2+ binding site [ion binding]; other site
391904003169	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
391904003170	synthetase active site [active]
391904003171	NTP binding site [chemical binding]; other site
391904003172	metal binding site [ion binding]; metal-binding site
391904003173	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
391904003174	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
391904003175	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
391904003176	active site
391904003177	HipA-like C-terminal domain; Region: HipA_C; pfam07804
391904003178	Fic family protein [Function unknown]; Region: COG3177
391904003179	Fic/DOC family; Region: Fic; pfam02661
391904003180	Integrase core domain; Region: rve; pfam00665
391904003181	Integrase core domain; Region: rve_3; cl15866
391904003182	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904003183	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904003184	putative substrate translocation pore; other site
391904003185	Transposase, Mutator family; Region: Transposase_mut; pfam00872
391904003186	MULE transposase domain; Region: MULE; pfam10551
391904003187	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
391904003188	FIC domain binding interface [polypeptide binding]; other site
391904003189	Fic/DOC family; Region: Fic; cl00960
391904003190	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904003191	active site
391904003192	Int/Topo IB signature motif; other site
391904003193	DNA binding site [nucleotide binding]
391904003194	Abi-like protein; Region: Abi_2; cl01988
391904003195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904003196	putative substrate translocation pore; other site
391904003197	Transposase; Region: DDE_Tnp_ISL3; pfam01610
391904003198	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
391904003199	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
391904003200	Reprolysin family propeptide; Region: Pep_M12B_propep; pfam01562
391904003201	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904003202	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904003203	Integrase core domain; Region: rve; pfam00665
391904003204	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904003205	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
391904003206	Walker A/P-loop; other site
391904003207	ATP binding site [chemical binding]; other site
391904003208	Q-loop/lid; other site
391904003209	ABC transporter signature motif; other site
391904003210	Walker B; other site
391904003211	D-loop; other site
391904003212	H-loop/switch region; other site
391904003213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
391904003214	MULE transposase domain; Region: MULE; pfam10551
391904003215	lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733
391904003216	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904003217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904003218	active site
391904003219	phosphorylation site [posttranslational modification]
391904003220	intermolecular recognition site; other site
391904003221	dimerization interface [polypeptide binding]; other site
391904003222	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391904003223	DNA binding site [nucleotide binding]
391904003224	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391904003225	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391904003226	dimer interface [polypeptide binding]; other site
391904003227	phosphorylation site [posttranslational modification]
391904003228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904003229	ATP binding site [chemical binding]; other site
391904003230	Mg2+ binding site [ion binding]; other site
391904003231	G-X-G motif; other site
391904003232	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
391904003233	EamA-like transporter family; Region: EamA; pfam00892
391904003234	EamA-like transporter family; Region: EamA; pfam00892
391904003235	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
391904003236	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
391904003237	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904003238	catalytic core [active]
391904003239	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
391904003240	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
391904003241	Cl binding site [ion binding]; other site
391904003242	oligomer interface [polypeptide binding]; other site
391904003243	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
391904003244	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904003245	substrate binding pocket [chemical binding]; other site
391904003246	membrane-bound complex binding site; other site
391904003247	hinge residues; other site
391904003248	aminoacyl-tRNA ligase; Region: PLN02563
391904003249	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391904003250	active site
391904003251	HIGH motif; other site
391904003252	nucleotide binding site [chemical binding]; other site
391904003253	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391904003254	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
391904003255	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391904003256	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391904003257	active site
391904003258	KMSKS motif; other site
391904003259	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
391904003260	tRNA binding surface [nucleotide binding]; other site
391904003261	Helix-hairpin-helix motif; Region: HHH; pfam00633
391904003262	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
391904003263	Competence protein; Region: Competence; pfam03772
391904003264	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
391904003265	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
391904003266	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
391904003267	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
391904003268	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
391904003269	Glycoprotease family; Region: Peptidase_M22; pfam00814
391904003270	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
391904003271	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904003272	Coenzyme A binding pocket [chemical binding]; other site
391904003273	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
391904003274	UGMP family protein; Validated; Region: PRK09604
391904003275	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
391904003276	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904003277	Putative amidase domain; Region: Amidase_6; pfam12671
391904003278	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904003279	Integrase core domain; Region: rve; pfam00665
391904003280	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904003281	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904003282	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904003283	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904003284	non-specific DNA binding site [nucleotide binding]; other site
391904003285	salt bridge; other site
391904003286	sequence-specific DNA binding site [nucleotide binding]; other site
391904003287	SdpI/YhfL protein family; Region: SdpI; pfam13630
391904003288	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
391904003289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904003290	S-adenosylmethionine binding site [chemical binding]; other site
391904003291	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904003292	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904003293	Walker A/P-loop; other site
391904003294	ATP binding site [chemical binding]; other site
391904003295	Q-loop/lid; other site
391904003296	ABC transporter signature motif; other site
391904003297	Walker B; other site
391904003298	D-loop; other site
391904003299	H-loop/switch region; other site
391904003300	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
391904003301	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
391904003302	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904003303	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
391904003304	Fic family protein [Function unknown]; Region: COG3177
391904003305	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904003306	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904003307	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904003308	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904003309	Walker A/P-loop; other site
391904003310	ATP binding site [chemical binding]; other site
391904003311	Q-loop/lid; other site
391904003312	ABC transporter signature motif; other site
391904003313	Walker B; other site
391904003314	D-loop; other site
391904003315	H-loop/switch region; other site
391904003316	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
391904003317	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
391904003318	Histidine kinase; Region: HisKA_3; pfam07730
391904003319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904003320	ATP binding site [chemical binding]; other site
391904003321	Mg2+ binding site [ion binding]; other site
391904003322	G-X-G motif; other site
391904003323	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904003324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904003325	active site
391904003326	phosphorylation site [posttranslational modification]
391904003327	intermolecular recognition site; other site
391904003328	dimerization interface [polypeptide binding]; other site
391904003329	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904003330	DNA binding residues [nucleotide binding]
391904003331	dimerization interface [polypeptide binding]; other site
391904003332	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
391904003333	Peptidase family M23; Region: Peptidase_M23; pfam01551
391904003334	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904003335	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904003336	isocitrate dehydrogenase; Validated; Region: PRK08299
391904003337	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
391904003338	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
391904003339	active site
391904003340	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
391904003341	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
391904003342	acyl-activating enzyme (AAE) consensus motif; other site
391904003343	putative AMP binding site [chemical binding]; other site
391904003344	putative active site [active]
391904003345	putative CoA binding site [chemical binding]; other site
391904003346	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
391904003347	active site
391904003348	catalytic residues [active]
391904003349	metal binding site [ion binding]; metal-binding site
391904003350	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
391904003351	rRNA interaction site [nucleotide binding]; other site
391904003352	S8 interaction site; other site
391904003353	putative laminin-1 binding site; other site
391904003354	elongation factor Ts; Provisional; Region: tsf; PRK09377
391904003355	Elongation factor TS; Region: EF_TS; pfam00889
391904003356	Elongation factor TS; Region: EF_TS; pfam00889
391904003357	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
391904003358	putative nucleotide binding site [chemical binding]; other site
391904003359	uridine monophosphate binding site [chemical binding]; other site
391904003360	homohexameric interface [polypeptide binding]; other site
391904003361	ribosome recycling factor; Reviewed; Region: frr; PRK00083
391904003362	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
391904003363	hinge region; other site
391904003364	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
391904003365	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
391904003366	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
391904003367	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391904003368	FeS/SAM binding site; other site
391904003369	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
391904003370	conserved cys residue [active]
391904003371	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
391904003372	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
391904003373	substrate binding site [chemical binding]; other site
391904003374	glutamase interaction surface [polypeptide binding]; other site
391904003375	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
391904003376	anthranilate synthase component I; Provisional; Region: PRK13571
391904003377	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
391904003378	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
391904003379	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
391904003380	putative substrate binding pocket [chemical binding]; other site
391904003381	AC domain interface; other site
391904003382	catalytic triad [active]
391904003383	AB domain interface; other site
391904003384	interchain disulfide; other site
391904003385	Predicted membrane protein [Function unknown]; Region: COG3817
391904003386	Protein of unknown function (DUF979); Region: DUF979; pfam06166
391904003387	Protein of unknown function (DUF969); Region: DUF969; cl01573
391904003388	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
391904003389	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904003390	Walker A/P-loop; other site
391904003391	ATP binding site [chemical binding]; other site
391904003392	Q-loop/lid; other site
391904003393	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904003394	ABC transporter signature motif; other site
391904003395	Walker B; other site
391904003396	D-loop; other site
391904003397	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904003398	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
391904003399	classical (c) SDRs; Region: SDR_c; cd05233
391904003400	NAD(P) binding site [chemical binding]; other site
391904003401	active site
391904003402	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
391904003403	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
391904003404	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
391904003405	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
391904003406	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904003407	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904003408	Walker A/P-loop; other site
391904003409	ATP binding site [chemical binding]; other site
391904003410	Q-loop/lid; other site
391904003411	ABC transporter signature motif; other site
391904003412	Walker B; other site
391904003413	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
391904003414	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
391904003415	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
391904003416	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
391904003417	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
391904003418	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
391904003419	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
391904003420	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
391904003421	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
391904003422	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
391904003423	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
391904003424	GIY-YIG motif/motif A; other site
391904003425	active site
391904003426	catalytic site [active]
391904003427	putative DNA binding site [nucleotide binding]; other site
391904003428	metal binding site [ion binding]; metal-binding site
391904003429	UvrB/uvrC motif; Region: UVR; pfam02151
391904003430	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
391904003431	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
391904003432	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
391904003433	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
391904003434	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
391904003435	shikimate binding site; other site
391904003436	NAD(P) binding site [chemical binding]; other site
391904003437	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
391904003438	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
391904003439	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
391904003440	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
391904003441	Phosphoglycerate kinase; Region: PGK; pfam00162
391904003442	substrate binding site [chemical binding]; other site
391904003443	hinge regions; other site
391904003444	ADP binding site [chemical binding]; other site
391904003445	catalytic site [active]
391904003446	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
391904003447	triosephosphate isomerase; Provisional; Region: PRK14567
391904003448	substrate binding site [chemical binding]; other site
391904003449	dimer interface [polypeptide binding]; other site
391904003450	catalytic triad [active]
391904003451	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
391904003452	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904003453	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
391904003454	NAD binding site [chemical binding]; other site
391904003455	dimer interface [polypeptide binding]; other site
391904003456	substrate binding site [chemical binding]; other site
391904003457	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
391904003458	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904003459	active site
391904003460	motif I; other site
391904003461	motif II; other site
391904003462	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
391904003463	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
391904003464	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904003465	non-specific DNA binding site [nucleotide binding]; other site
391904003466	salt bridge; other site
391904003467	sequence-specific DNA binding site [nucleotide binding]; other site
391904003468	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904003469	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904003470	homodimer interface [polypeptide binding]; other site
391904003471	catalytic residue [active]
391904003472	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
391904003473	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
391904003474	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
391904003475	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
391904003476	putative active site [active]
391904003477	transaldolase; Provisional; Region: PRK03903
391904003478	catalytic residue [active]
391904003479	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
391904003480	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
391904003481	TPP-binding site [chemical binding]; other site
391904003482	dimer interface [polypeptide binding]; other site
391904003483	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
391904003484	PYR/PP interface [polypeptide binding]; other site
391904003485	dimer interface [polypeptide binding]; other site
391904003486	TPP binding site [chemical binding]; other site
391904003487	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
391904003488	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
391904003489	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
391904003490	chaperone protein DnaJ; Provisional; Region: PRK14278
391904003491	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
391904003492	HSP70 interaction site [polypeptide binding]; other site
391904003493	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
391904003494	Zn binding sites [ion binding]; other site
391904003495	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
391904003496	dimer interface [polypeptide binding]; other site
391904003497	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
391904003498	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
391904003499	active site
391904003500	Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582
391904003501	Phage tail protein; Region: Sipho_tail; pfam05709
391904003502	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
391904003503	Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355
391904003504	Phage capsid family; Region: Phage_capsid; pfam05065
391904003505	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
391904003506	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
391904003507	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
391904003508	polymerase nucleotide-binding site; other site
391904003509	DNA-binding residues [nucleotide binding]; DNA binding site
391904003510	nucleotide binding site [chemical binding]; other site
391904003511	primase nucleotide-binding site [nucleotide binding]; other site
391904003512	AAA domain; Region: AAA_25; pfam13481
391904003513	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391904003514	Walker A motif; other site
391904003515	ATP binding site [chemical binding]; other site
391904003516	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
391904003517	G1 box; other site
391904003518	GTP/Mg2+ binding site [chemical binding]; other site
391904003519	G2 box; other site
391904003520	Switch I region; other site
391904003521	G3 box; other site
391904003522	Switch II region; other site
391904003523	Endodeoxyribonuclease RusA; Region: RusA; cl01885
391904003524	Helix-turn-helix domain; Region: HTH_17; cl17695
391904003525	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
391904003526	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
391904003527	Domain of unknown function (DUF955); Region: DUF955; pfam06114
391904003528	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
391904003529	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
391904003530	cofactor binding site; other site
391904003531	DNA binding site [nucleotide binding]
391904003532	substrate interaction site [chemical binding]; other site
391904003533	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
391904003534	ATP binding site [chemical binding]; other site
391904003535	Mg2+ binding site [ion binding]; other site
391904003536	G-X-G motif; other site
391904003537	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
391904003538	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904003539	active site
391904003540	DNA binding site [nucleotide binding]
391904003541	Int/Topo IB signature motif; other site
391904003542	Phosphotransferase enzyme family; Region: APH; pfam01636
391904003543	Fructosamine kinase; Region: Fructosamin_kin; cl17579
391904003544	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
391904003545	PAC2 family; Region: PAC2; pfam09754
391904003546	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
391904003547	thiS-thiF/thiG interaction site; other site
391904003548	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
391904003549	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
391904003550	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
391904003551	active site
391904003552	dimer interface [polypeptide binding]; other site
391904003553	motif 1; other site
391904003554	motif 2; other site
391904003555	motif 3; other site
391904003556	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
391904003557	anticodon binding site; other site
391904003558	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
391904003559	nucleotide binding site/active site [active]
391904003560	HIT family signature motif; other site
391904003561	catalytic residue [active]
391904003562	hypothetical protein; Validated; Region: PRK00110
391904003563	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
391904003564	active site
391904003565	putative DNA-binding cleft [nucleotide binding]; other site
391904003566	dimer interface [polypeptide binding]; other site
391904003567	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
391904003568	RuvA N terminal domain; Region: RuvA_N; pfam01330
391904003569	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
391904003570	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
391904003571	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904003572	Walker A motif; other site
391904003573	ATP binding site [chemical binding]; other site
391904003574	Walker B motif; other site
391904003575	arginine finger; other site
391904003576	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
391904003577	Preprotein translocase subunit; Region: YajC; pfam02699
391904003578	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904003579	active site
391904003580	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
391904003581	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
391904003582	CoA-ligase; Region: Ligase_CoA; pfam00549
391904003583	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
391904003584	CoA binding domain; Region: CoA_binding; smart00881
391904003585	CoA-ligase; Region: Ligase_CoA; pfam00549
391904003586	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
391904003587	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
391904003588	purine monophosphate binding site [chemical binding]; other site
391904003589	dimer interface [polypeptide binding]; other site
391904003590	putative catalytic residues [active]
391904003591	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
391904003592	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
391904003593	amphipathic channel; other site
391904003594	Asn-Pro-Ala signature motifs; other site
391904003595	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
391904003596	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391904003597	RNA binding surface [nucleotide binding]; other site
391904003598	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
391904003599	active site
391904003600	bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518
391904003601	AAA domain; Region: AAA_17; pfam13207
391904003602	Cytidylate kinase; Region: Cytidylate_kin; pfam02224
391904003603	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
391904003604	G1 box; other site
391904003605	GTP/Mg2+ binding site [chemical binding]; other site
391904003606	Switch I region; other site
391904003607	G2 box; other site
391904003608	Switch II region; other site
391904003609	G3 box; other site
391904003610	G4 box; other site
391904003611	G5 box; other site
391904003612	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
391904003613	G1 box; other site
391904003614	GTP/Mg2+ binding site [chemical binding]; other site
391904003615	Switch I region; other site
391904003616	G2 box; other site
391904003617	G3 box; other site
391904003618	Switch II region; other site
391904003619	G4 box; other site
391904003620	G5 box; other site
391904003621	MULE transposase domain; Region: MULE; pfam10551
391904003622	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391904003623	active site
391904003624	Predicted transcriptional regulator [Transcription]; Region: COG2378
391904003625	WYL domain; Region: WYL; pfam13280
391904003626	DEAD-like helicases superfamily; Region: DEXDc; smart00487
391904003627	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904003628	ATP binding site [chemical binding]; other site
391904003629	putative Mg++ binding site [ion binding]; other site
391904003630	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904003631	nucleotide binding region [chemical binding]; other site
391904003632	ATP-binding site [chemical binding]; other site
391904003633	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
391904003634	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
391904003635	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
391904003636	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904003637	motif II; other site
391904003638	Helix-turn-helix domain; Region: HTH_17; pfam12728
391904003639	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
391904003640	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
391904003641	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
391904003642	ATP binding site [chemical binding]; other site
391904003643	putative Mg++ binding site [ion binding]; other site
391904003644	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904003645	nucleotide binding region [chemical binding]; other site
391904003646	ATP-binding site [chemical binding]; other site
391904003647	Probable transposase; Region: OrfB_IS605; pfam01385
391904003648	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
391904003649	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
391904003650	VRR-NUC domain; Region: VRR_NUC; pfam08774
391904003651	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
391904003652	active site
391904003653	NTP binding site [chemical binding]; other site
391904003654	metal binding triad [ion binding]; metal-binding site
391904003655	Fic/DOC family; Region: Fic; pfam02661
391904003656	Probable transposase; Region: OrfB_IS605; pfam01385
391904003657	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
391904003658	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
391904003659	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
391904003660	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
391904003661	CHAP domain; Region: CHAP; pfam05257
391904003662	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
391904003663	active site
391904003664	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
391904003665	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
391904003666	DNA methylase; Region: N6_N4_Mtase; cl17433
391904003667	DNA methylase; Region: N6_N4_Mtase; pfam01555
391904003668	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
391904003669	DNA-directed RNA polymerase subunit A''; Provisional; Region: PRK14898
391904003670	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
391904003671	cofactor binding site; other site
391904003672	DNA binding site [nucleotide binding]
391904003673	substrate interaction site [chemical binding]; other site
391904003674	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
391904003675	DivIVA protein; Region: DivIVA; pfam05103
391904003676	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
391904003677	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
391904003678	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
391904003679	catalytic residues [active]
391904003680	catalytic nucleophile [active]
391904003681	Probable transposase; Region: OrfB_IS605; pfam01385
391904003682	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
391904003683	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
391904003684	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
391904003685	DNA binding site [nucleotide binding]
391904003686	active site
391904003687	Int/Topo IB signature motif; other site
391904003688	catalytic residues [active]
391904003689	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
391904003690	DNA protecting protein DprA; Region: dprA; TIGR00732
391904003691	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904003692	active site
391904003693	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
391904003694	active site
391904003695	catalytic site [active]
391904003696	substrate binding site [chemical binding]; other site
391904003697	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904003698	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904003699	salt bridge; other site
391904003700	non-specific DNA binding site [nucleotide binding]; other site
391904003701	sequence-specific DNA binding site [nucleotide binding]; other site
391904003702	PIF1-like helicase; Region: PIF1; pfam05970
391904003703	AAA domain; Region: AAA_30; pfam13604
391904003704	Family description; Region: UvrD_C_2; pfam13538
391904003705	T surface-antigen of pili; Region: FctA; cl16948
391904003706	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
391904003707	thioester formation/cholesterol transfer; other site
391904003708	Hom_end-associated Hint; Region: Hom_end_hint; pfam05203
391904003709	Homing endonuclease; Region: Hom_end; pfam05204
391904003710	AAA-like domain; Region: AAA_10; pfam12846
391904003711	CHAP domain; Region: CHAP; pfam05257
391904003712	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
391904003713	DNA polymerase III subunit beta; Validated; Region: PRK07761
391904003714	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512
391904003715	putative DNA binding surface [nucleotide binding]; other site
391904003716	dimer interface [polypeptide binding]; other site
391904003717	beta-clamp/clamp loader binding surface; other site
391904003718	beta-clamp/translesion DNA polymerase binding surface; other site
391904003719	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
391904003720	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
391904003721	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904003722	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
391904003723	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
391904003724	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
391904003725	T surface-antigen of pili; Region: FctA; pfam12892
391904003726	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
391904003727	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
391904003728	T surface-antigen of pili; Region: FctA; pfam12892
391904003729	T surface-antigen of pili; Region: FctA; pfam12892
391904003730	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
391904003731	AAA domain; Region: AAA_17; pfam13207
391904003732	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
391904003733	polymerase nucleotide-binding site; other site
391904003734	DNA-binding residues [nucleotide binding]; DNA binding site
391904003735	nucleotide binding site [chemical binding]; other site
391904003736	primase nucleotide-binding site [nucleotide binding]; other site
391904003737	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
391904003738	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
391904003739	Transcription factor WhiB; Region: Whib; pfam02467
391904003740	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
391904003741	carbon starvation protein A; Provisional; Region: PRK15015
391904003742	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
391904003743	active site
391904003744	catalytic site [active]
391904003745	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
391904003746	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
391904003747	active site
391904003748	metal binding site [ion binding]; metal-binding site
391904003749	putative RNA ligase; Region: PHA02142
391904003750	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
391904003751	FemAB family; Region: FemAB; pfam02388
391904003752	Uncharacterized conserved protein [Function unknown]; Region: COG4933
391904003753	Transposase IS200 like; Region: Y1_Tnp; pfam01797
391904003754	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
391904003755	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
391904003756	Probable transposase; Region: OrfB_IS605; pfam01385
391904003757	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350
391904003758	iron binding site [ion binding]; other site
391904003759	hypothetical protein; Provisional; Region: PRK06148
391904003760	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
391904003761	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
391904003762	Probable transposase; Region: OrfB_IS605; pfam01385
391904003763	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
391904003764	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
391904003765	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
391904003766	Domain of unknown function (DUF3841); Region: DUF3841; pfam12952
391904003767	Methyltransferase domain; Region: Methyltransf_26; pfam13659
391904003768	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904003769	non-specific DNA binding site [nucleotide binding]; other site
391904003770	salt bridge; other site
391904003771	sequence-specific DNA binding site [nucleotide binding]; other site
391904003772	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
391904003773	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
391904003774	DNA methylase; Region: N6_N4_Mtase; cl17433
391904003775	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
391904003776	DNA methylase; Region: N6_N4_Mtase; pfam01555
391904003777	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904003778	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
391904003779	active site
391904003780	DNA binding site [nucleotide binding]
391904003781	Int/Topo IB signature motif; other site
391904003782	DNA methylase; Region: N6_N4_Mtase; cl17433
391904003783	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
391904003784	DNA methylase; Region: N6_N4_Mtase; pfam01555
391904003785	Probable transposase; Region: OrfB_IS605; pfam01385
391904003786	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
391904003787	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
391904003788	HipA N-terminal domain; Region: Couple_hipA; pfam13657
391904003789	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
391904003790	HipA-like N-terminal domain; Region: HipA_N; pfam07805
391904003791	HipA-like C-terminal domain; Region: HipA_C; pfam07804
391904003792	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904003793	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904003794	Integrase core domain; Region: rve; pfam00665
391904003795	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904003796	ABC transporter signature motif; other site
391904003797	Walker B; other site
391904003798	D-loop; other site
391904003799	H-loop/switch region; other site
391904003800	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904003801	FtsX-like permease family; Region: FtsX; pfam02687
391904003802	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
391904003803	DNA binding residues [nucleotide binding]
391904003804	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
391904003805	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
391904003806	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
391904003807	phosphopeptide binding site; other site
391904003808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
391904003809	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
391904003810	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
391904003811	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
391904003812	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
391904003813	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
391904003814	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
391904003815	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
391904003816	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
391904003817	homodimer interface [polypeptide binding]; other site
391904003818	putative metal binding site [ion binding]; other site
391904003819	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
391904003820	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
391904003821	substrate binding site [chemical binding]; other site
391904003822	hexamer interface [polypeptide binding]; other site
391904003823	metal binding site [ion binding]; metal-binding site
391904003824	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
391904003825	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
391904003826	substrate binding site [chemical binding]; other site
391904003827	active site
391904003828	catalytic residues [active]
391904003829	heterodimer interface [polypeptide binding]; other site
391904003830	bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802
391904003831	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
391904003832	active site
391904003833	ribulose/triose binding site [chemical binding]; other site
391904003834	phosphate binding site [ion binding]; other site
391904003835	substrate (anthranilate) binding pocket [chemical binding]; other site
391904003836	product (indole) binding pocket [chemical binding]; other site
391904003837	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
391904003838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904003839	catalytic residue [active]
391904003840	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
391904003841	endonuclease IV; Provisional; Region: PRK01060
391904003842	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
391904003843	AP (apurinic/apyrimidinic) site pocket; other site
391904003844	DNA interaction; other site
391904003845	Metal-binding active site; metal-binding site
391904003846	S-methylmethionine transporter; Provisional; Region: PRK11387
391904003847	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904003848	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904003849	VanZ like family; Region: VanZ; pfam04892
391904003850	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
391904003851	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904003852	catalytic residue [active]
391904003853	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904003854	Coenzyme A binding pocket [chemical binding]; other site
391904003855	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805
391904003856	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
391904003857	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
391904003858	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
391904003859	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
391904003860	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478
391904003861	Na binding site [ion binding]; other site
391904003862	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904003863	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
391904003864	active site
391904003865	Abi-like protein; Region: Abi_2; pfam07751
391904003866	Histidine kinase; Region: HisKA_3; pfam07730
391904003867	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904003868	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
391904003869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904003870	active site
391904003871	phosphorylation site [posttranslational modification]
391904003872	intermolecular recognition site; other site
391904003873	dimerization interface [polypeptide binding]; other site
391904003874	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
391904003875	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
391904003876	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904003877	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904003878	Walker A/P-loop; other site
391904003879	ATP binding site [chemical binding]; other site
391904003880	Q-loop/lid; other site
391904003881	ABC transporter signature motif; other site
391904003882	Walker B; other site
391904003883	D-loop; other site
391904003884	H-loop/switch region; other site
391904003885	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904003886	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904003887	FtsX-like permease family; Region: FtsX; pfam02687
391904003888	RelB antitoxin; Region: RelB; cl01171
391904003889	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
391904003890	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
391904003891	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
391904003892	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
391904003893	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904003894	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
391904003895	Walker A/P-loop; other site
391904003896	ATP binding site [chemical binding]; other site
391904003897	Q-loop/lid; other site
391904003898	ABC transporter signature motif; other site
391904003899	Walker B; other site
391904003900	D-loop; other site
391904003901	H-loop/switch region; other site
391904003902	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
391904003903	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904003904	ABC transporter signature motif; other site
391904003905	Walker B; other site
391904003906	D-loop; other site
391904003907	H-loop/switch region; other site
391904003908	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904003909	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904003910	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904003911	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904003912	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904003913	Integrase core domain; Region: rve; pfam00665
391904003914	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904003915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904003916	active site
391904003917	phosphorylation site [posttranslational modification]
391904003918	intermolecular recognition site; other site
391904003919	dimerization interface [polypeptide binding]; other site
391904003920	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904003921	DNA binding residues [nucleotide binding]
391904003922	dimerization interface [polypeptide binding]; other site
391904003923	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904003924	Histidine kinase; Region: HisKA_3; pfam07730
391904003925	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
391904003926	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904003927	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904003928	Walker A/P-loop; other site
391904003929	ATP binding site [chemical binding]; other site
391904003930	Q-loop/lid; other site
391904003931	ABC transporter signature motif; other site
391904003932	Walker B; other site
391904003933	D-loop; other site
391904003934	H-loop/switch region; other site
391904003935	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
391904003936	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
391904003937	DNA binding residues [nucleotide binding]
391904003938	Predicted amidohydrolase [General function prediction only]; Region: COG0388
391904003939	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
391904003940	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
391904003941	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
391904003942	nudix motif; other site
391904003943	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
391904003944	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904003945	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904003946	S-methylmethionine transporter; Provisional; Region: PRK11387
391904003947	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
391904003948	Uncharacterized conserved protein [Function unknown]; Region: COG3189
391904003949	Domain of unknown function (DUF1287); Region: DUF1287; cl01519
391904003950	Fic/DOC family; Region: Fic; pfam02661
391904003951	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
391904003952	Uncharacterized conserved protein [Function unknown]; Region: COG3189
391904003953	C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126
391904003954	aspartate aminotransferase; Provisional; Region: PRK06836
391904003955	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904003956	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904003957	homodimer interface [polypeptide binding]; other site
391904003958	catalytic residue [active]
391904003959	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
391904003960	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
391904003961	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
391904003962	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904003963	motif II; other site
391904003964	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904003965	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391904003966	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391904003967	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
391904003968	dimerization interface [polypeptide binding]; other site
391904003969	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
391904003970	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904003971	active site
391904003972	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
391904003973	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
391904003974	heterodimer interface [polypeptide binding]; other site
391904003975	active site
391904003976	FMN binding site [chemical binding]; other site
391904003977	homodimer interface [polypeptide binding]; other site
391904003978	substrate binding site [chemical binding]; other site
391904003979	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
391904003980	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
391904003981	FAD binding pocket [chemical binding]; other site
391904003982	FAD binding motif [chemical binding]; other site
391904003983	phosphate binding motif [ion binding]; other site
391904003984	beta-alpha-beta structure motif; other site
391904003985	NAD binding pocket [chemical binding]; other site
391904003986	Iron coordination center [ion binding]; other site
391904003987	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
391904003988	active site
391904003989	dimer interface [polypeptide binding]; other site
391904003990	dihydroorotase; Validated; Region: pyrC; PRK09357
391904003991	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
391904003992	active site
391904003993	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
391904003994	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
391904003995	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
391904003996	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
391904003997	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
391904003998	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
391904003999	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
391904004000	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
391904004001	metal binding triad; other site
391904004002	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
391904004003	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
391904004004	metal binding triad; other site
391904004005	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
391904004006	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
391904004007	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
391904004008	active site
391904004009	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
391904004010	FAD binding site [chemical binding]; other site
391904004011	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
391904004012	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
391904004013	THF binding site; other site
391904004014	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
391904004015	substrate binding site [chemical binding]; other site
391904004016	THF binding site; other site
391904004017	zinc-binding site [ion binding]; other site
391904004018	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904004019	catalytic core [active]
391904004020	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
391904004021	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904004022	S-adenosylmethionine binding site [chemical binding]; other site
391904004023	putative hydrolase; Provisional; Region: PRK11460
391904004024	Putative transcription activator [Transcription]; Region: TenA; COG0819
391904004025	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
391904004026	active site
391904004027	metal binding site [ion binding]; metal-binding site
391904004028	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
391904004029	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391904004030	SWIM zinc finger; Region: SWIM; pfam04434
391904004031	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
391904004032	Predicted permeases [General function prediction only]; Region: RarD; COG2962
391904004033	GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439
391904004034	GIY-YIG motif/motif A; other site
391904004035	putative active site [active]
391904004036	putative metal binding site [ion binding]; other site
391904004037	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
391904004038	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
391904004039	Uncharacterized conserved protein [Function unknown]; Region: COG3410
391904004040	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
391904004041	homodimer interface [polypeptide binding]; other site
391904004042	chemical substrate binding site [chemical binding]; other site
391904004043	oligomer interface [polypeptide binding]; other site
391904004044	metal binding site [ion binding]; metal-binding site
391904004045	Uncharacterized conserved protein [Function unknown]; Region: COG4715
391904004046	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
391904004047	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
391904004048	catalytic triad [active]
391904004049	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
391904004050	Transposase, Mutator family; Region: Transposase_mut; pfam00872
391904004051	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904004052	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
391904004053	active site
391904004054	motif I; other site
391904004055	motif II; other site
391904004056	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
391904004057	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
391904004058	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
391904004059	Walker A/P-loop; other site
391904004060	ATP binding site [chemical binding]; other site
391904004061	Q-loop/lid; other site
391904004062	ABC transporter signature motif; other site
391904004063	Walker B; other site
391904004064	D-loop; other site
391904004065	H-loop/switch region; other site
391904004066	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
391904004067	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
391904004068	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
391904004069	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
391904004070	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
391904004071	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
391904004072	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391904004073	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
391904004074	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
391904004075	active site
391904004076	dimer interface [polypeptide binding]; other site
391904004077	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
391904004078	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
391904004079	active site
391904004080	FMN binding site [chemical binding]; other site
391904004081	substrate binding site [chemical binding]; other site
391904004082	3Fe-4S cluster binding site [ion binding]; other site
391904004083	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
391904004084	domain interface; other site
391904004085	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904004086	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904004087	DNA binding site [nucleotide binding]
391904004088	domain linker motif; other site
391904004089	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
391904004090	ligand binding site [chemical binding]; other site
391904004091	dimerization interface (open form) [polypeptide binding]; other site
391904004092	dimerization interface (closed form) [polypeptide binding]; other site
391904004093	glycerate kinase; Region: TIGR00045
391904004094	coproporphyrinogen III oxidase; Validated; Region: PRK05628
391904004095	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391904004096	FeS/SAM binding site; other site
391904004097	HemN C-terminal domain; Region: HemN_C; pfam06969
391904004098	GTP-binding protein LepA; Provisional; Region: PRK05433
391904004099	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
391904004100	G1 box; other site
391904004101	putative GEF interaction site [polypeptide binding]; other site
391904004102	GTP/Mg2+ binding site [chemical binding]; other site
391904004103	Switch I region; other site
391904004104	G2 box; other site
391904004105	G3 box; other site
391904004106	Switch II region; other site
391904004107	G4 box; other site
391904004108	G5 box; other site
391904004109	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
391904004110	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
391904004111	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
391904004112	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
391904004113	UPF0126 domain; Region: UPF0126; pfam03458
391904004114	Predicted membrane protein [Function unknown]; Region: COG2860
391904004115	UPF0126 domain; Region: UPF0126; pfam03458
391904004116	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
391904004117	homodimer interface [polypeptide binding]; other site
391904004118	MazG family protein; Region: mazG; TIGR00444
391904004119	metal binding site [ion binding]; metal-binding site
391904004120	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904004121	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904004122	active site
391904004123	Int/Topo IB signature motif; other site
391904004124	DNA binding site [nucleotide binding]
391904004125	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
391904004126	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
391904004127	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
391904004128	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904004129	sequence-specific DNA binding site [nucleotide binding]; other site
391904004130	salt bridge; other site
391904004131	DivIVA domain; Region: DivI1A_domain; TIGR03544
391904004132	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904004133	ERF superfamily; Region: ERF; pfam04404
391904004134	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
391904004135	ssDNA binding site [nucleotide binding]; other site
391904004136	dimer interface [polypeptide binding]; other site
391904004137	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904004138	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
391904004139	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
391904004140	BRO family, N-terminal domain; Region: Bro-N; pfam02498
391904004141	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
391904004142	cofactor binding site; other site
391904004143	DNA binding site [nucleotide binding]
391904004144	substrate interaction site [chemical binding]; other site
391904004145	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
391904004146	Prophage antirepressor [Transcription]; Region: COG3617
391904004147	BRO family, N-terminal domain; Region: Bro-N; smart01040
391904004148	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
391904004149	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
391904004150	DNA binding site [nucleotide binding]
391904004151	active site
391904004152	Int/Topo IB signature motif; other site
391904004153	catalytic residues [active]
391904004154	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
391904004155	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
391904004156	PemK-like protein; Region: PemK; pfam02452
391904004157	RelB antitoxin; Region: RelB; cl01171
391904004158	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020
391904004159	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
391904004160	active site
391904004161	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
391904004162	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
391904004163	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
391904004164	Head fiber protein; Region: Phage_head_fibr; pfam11133
391904004165	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
391904004166	Intermediate filament protein; Region: Filament; pfam00038
391904004167	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
391904004168	Interdomain contacts; other site
391904004169	Cytokine receptor motif; other site
391904004170	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904004171	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904004172	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904004173	LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.  The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417
391904004174	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
391904004175	active site
391904004176	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; pfam08230
391904004177	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
391904004178	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
391904004179	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
391904004180	homodimer interface [polypeptide binding]; other site
391904004181	substrate-cofactor binding pocket; other site
391904004182	catalytic residue [active]
391904004183	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
391904004184	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
391904004185	5S rRNA interface [nucleotide binding]; other site
391904004186	CTC domain interface [polypeptide binding]; other site
391904004187	L16 interface [polypeptide binding]; other site
391904004188	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
391904004189	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
391904004190	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
391904004191	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
391904004192	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
391904004193	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
391904004194	ligand binding site [chemical binding]; other site
391904004195	homodimer interface [polypeptide binding]; other site
391904004196	NAD(P) binding site [chemical binding]; other site
391904004197	trimer interface B [polypeptide binding]; other site
391904004198	trimer interface A [polypeptide binding]; other site
391904004199	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
391904004200	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
391904004201	acyl-activating enzyme (AAE) consensus motif; other site
391904004202	putative AMP binding site [chemical binding]; other site
391904004203	putative active site [active]
391904004204	putative CoA binding site [chemical binding]; other site
391904004205	GTPase Era; Reviewed; Region: era; PRK00089
391904004206	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
391904004207	G1 box; other site
391904004208	GTP/Mg2+ binding site [chemical binding]; other site
391904004209	Switch I region; other site
391904004210	G2 box; other site
391904004211	Switch II region; other site
391904004212	G3 box; other site
391904004213	G4 box; other site
391904004214	G5 box; other site
391904004215	KH domain; Region: KH_2; pfam07650
391904004216	Domain of unknown function DUF21; Region: DUF21; pfam01595
391904004217	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
391904004218	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
391904004219	Transporter associated domain; Region: CorC_HlyC; smart01091
391904004220	metal-binding heat shock protein; Provisional; Region: PRK00016
391904004221	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
391904004222	PhoH-like protein; Region: PhoH; pfam02562
391904004223	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
391904004224	nucleotide binding site/active site [active]
391904004225	HIT family signature motif; other site
391904004226	catalytic residue [active]
391904004227	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
391904004228	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
391904004229	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
391904004230	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
391904004231	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
391904004232	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
391904004233	ligand binding site; other site
391904004234	oligomer interface; other site
391904004235	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
391904004236	dimer interface [polypeptide binding]; other site
391904004237	N-terminal domain interface [polypeptide binding]; other site
391904004238	sulfate 1 binding site; other site
391904004239	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
391904004240	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
391904004241	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
391904004242	trimerization site [polypeptide binding]; other site
391904004243	active site
391904004244	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
391904004245	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
391904004246	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904004247	catalytic residue [active]
391904004248	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
391904004249	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
391904004250	Walker A/P-loop; other site
391904004251	ATP binding site [chemical binding]; other site
391904004252	Q-loop/lid; other site
391904004253	ABC transporter signature motif; other site
391904004254	Walker B; other site
391904004255	D-loop; other site
391904004256	H-loop/switch region; other site
391904004257	FeS assembly protein SufD; Region: sufD; TIGR01981
391904004258	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
391904004259	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
391904004260	FeS assembly protein SufB; Region: sufB; TIGR01980
391904004261	CTP synthetase; Validated; Region: pyrG; PRK05380
391904004262	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
391904004263	Catalytic site [active]
391904004264	active site
391904004265	UTP binding site [chemical binding]; other site
391904004266	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
391904004267	active site
391904004268	putative oxyanion hole; other site
391904004269	catalytic triad [active]
391904004270	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
391904004271	Dehydroquinase class II; Region: DHquinase_II; pfam01220
391904004272	trimer interface [polypeptide binding]; other site
391904004273	active site
391904004274	dimer interface [polypeptide binding]; other site
391904004275	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
391904004276	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
391904004277	ADP binding site [chemical binding]; other site
391904004278	magnesium binding site [ion binding]; other site
391904004279	putative shikimate binding site; other site
391904004280	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
391904004281	active site
391904004282	dimer interface [polypeptide binding]; other site
391904004283	metal binding site [ion binding]; metal-binding site
391904004284	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
391904004285	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
391904004286	Tetramer interface [polypeptide binding]; other site
391904004287	active site
391904004288	FMN-binding site [chemical binding]; other site
391904004289	YceG-like family; Region: YceG; pfam02618
391904004290	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
391904004291	dimerization interface [polypeptide binding]; other site
391904004292	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
391904004293	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
391904004294	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
391904004295	motif 1; other site
391904004296	active site
391904004297	motif 2; other site
391904004298	motif 3; other site
391904004299	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
391904004300	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
391904004301	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904004302	catalytic core [active]
391904004303	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
391904004304	RelB antitoxin; Region: RelB; cl01171
391904004305	PemK-like protein; Region: PemK; pfam02452
391904004306	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
391904004307	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
391904004308	SdpI/YhfL protein family; Region: SdpI; pfam13630
391904004309	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
391904004310	active site
391904004311	catalytic motif [active]
391904004312	Zn binding site [ion binding]; other site
391904004313	Peptidase C26; Region: Peptidase_C26; pfam07722
391904004314	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
391904004315	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
391904004316	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
391904004317	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
391904004318	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391904004319	RNA binding surface [nucleotide binding]; other site
391904004320	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904004321	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904004322	Walker A/P-loop; other site
391904004323	ATP binding site [chemical binding]; other site
391904004324	Q-loop/lid; other site
391904004325	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904004326	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904004327	ABC transporter signature motif; other site
391904004328	Walker B; other site
391904004329	D-loop; other site
391904004330	H-loop/switch region; other site
391904004331	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904004332	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904004333	FtsX-like permease family; Region: FtsX; pfam02687
391904004334	Domain of unknown function (DUF4418); Region: DUF4418; pfam14387
391904004335	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
391904004336	Part of AAA domain; Region: AAA_19; pfam13245
391904004337	Family description; Region: UvrD_C_2; pfam13538
391904004338	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904004339	active site
391904004340	xanthine permease; Region: pbuX; TIGR03173
391904004341	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904004342	salt bridge; other site
391904004343	non-specific DNA binding site [nucleotide binding]; other site
391904004344	sequence-specific DNA binding site [nucleotide binding]; other site
391904004345	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
391904004346	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
391904004347	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
391904004348	Isochorismatase family; Region: Isochorismatase; pfam00857
391904004349	catalytic triad [active]
391904004350	metal binding site [ion binding]; metal-binding site
391904004351	conserved cis-peptide bond; other site
391904004352	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
391904004353	conserved cys residue [active]
391904004354	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
391904004355	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
391904004356	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
391904004357	DNA binding residues [nucleotide binding]
391904004358	PIN domain; Region: PIN_3; pfam13470
391904004359	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
391904004360	Divergent AAA domain; Region: AAA_4; pfam04326
391904004361	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
391904004362	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
391904004363	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
391904004364	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
391904004365	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904004366	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391904004367	Walker A/P-loop; other site
391904004368	ATP binding site [chemical binding]; other site
391904004369	Q-loop/lid; other site
391904004370	ABC transporter signature motif; other site
391904004371	Walker B; other site
391904004372	D-loop; other site
391904004373	H-loop/switch region; other site
391904004374	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
391904004375	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904004376	Histidine kinase; Region: HisKA_3; pfam07730
391904004377	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904004378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904004379	active site
391904004380	phosphorylation site [posttranslational modification]
391904004381	intermolecular recognition site; other site
391904004382	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904004383	DNA binding residues [nucleotide binding]
391904004384	dimerization interface [polypeptide binding]; other site
391904004385	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
391904004386	Phosphate transporter family; Region: PHO4; pfam01384
391904004387	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
391904004388	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
391904004389	active site
391904004390	catalytic site [active]
391904004391	potential frameshift: common BLAST hit: gi|296453984|ref|YP_003661127.1| transmembrane efflux protein
391904004392	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
391904004393	helicase 45; Provisional; Region: PTZ00424
391904004394	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
391904004395	ATP binding site [chemical binding]; other site
391904004396	putative Mg++ binding site [ion binding]; other site
391904004397	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904004398	nucleotide binding region [chemical binding]; other site
391904004399	ATP-binding site [chemical binding]; other site
391904004400	uracil transporter; Provisional; Region: PRK10720
391904004401	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904004402	catalytic core [active]
391904004403	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
391904004404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904004405	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904004406	putative substrate translocation pore; other site
391904004407	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
391904004408	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
391904004409	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
391904004410	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
391904004411	G1 box; other site
391904004412	GTP/Mg2+ binding site [chemical binding]; other site
391904004413	Switch I region; other site
391904004414	G2 box; other site
391904004415	G3 box; other site
391904004416	Switch II region; other site
391904004417	G4 box; other site
391904004418	G5 box; other site
391904004419	Nucleoside recognition; Region: Gate; pfam07670
391904004420	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
391904004421	putative transporter; Provisional; Region: PRK10504
391904004422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904004423	putative substrate translocation pore; other site
391904004424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904004425	FOG: CBS domain [General function prediction only]; Region: COG0517
391904004426	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636
391904004427	Domain of unknown function (DUF307); Region: DUF307; pfam03733
391904004428	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
391904004429	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
391904004430	active site
391904004431	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
391904004432	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
391904004433	active site
391904004434	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904004435	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904004436	Integrase core domain; Region: rve; pfam00665
391904004437	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
391904004438	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904004439	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904004440	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
391904004441	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904004442	Coenzyme A binding pocket [chemical binding]; other site
391904004443	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
391904004444	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
391904004445	PrgI family protein; Region: PrgI; pfam12666
391904004446	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
391904004447	Integrase core domain; Region: rve; pfam00665
391904004448	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
391904004449	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904004450	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391904004451	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904004452	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904004453	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
391904004454	HipA-like C-terminal domain; Region: HipA_C; pfam07804
391904004455	RelB antitoxin; Region: RelB; cl01171
391904004456	PemK-like protein; Region: PemK; pfam02452
391904004457	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
391904004458	Methyltransferase domain; Region: Methyltransf_23; pfam13489
391904004459	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904004460	S-adenosylmethionine binding site [chemical binding]; other site
391904004461	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
391904004462	hypothetical protein; Provisional; Region: PRK11770
391904004463	Domain of unknown function (DUF307); Region: DUF307; pfam03733
391904004464	Domain of unknown function (DUF307); Region: DUF307; pfam03733
391904004465	Fic family protein [Function unknown]; Region: COG3177
391904004466	Fic/DOC family; Region: Fic; pfam02661
391904004467	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904004468	Walker A/P-loop; other site
391904004469	ATP binding site [chemical binding]; other site
391904004470	Q-loop/lid; other site
391904004471	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
391904004472	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904004473	AAA domain; Region: AAA_21; pfam13304
391904004474	Walker A/P-loop; other site
391904004475	ATP binding site [chemical binding]; other site
391904004476	Q-loop/lid; other site
391904004477	ABC transporter signature motif; other site
391904004478	Walker B; other site
391904004479	D-loop; other site
391904004480	H-loop/switch region; other site
391904004481	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
391904004482	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
391904004483	TfoX C-terminal domain; Region: TfoX_C; pfam04994
391904004484	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
391904004485	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
391904004486	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
391904004487	GTP-binding protein YchF; Reviewed; Region: PRK09601
391904004488	YchF GTPase; Region: YchF; cd01900
391904004489	G1 box; other site
391904004490	GTP/Mg2+ binding site [chemical binding]; other site
391904004491	Switch I region; other site
391904004492	G2 box; other site
391904004493	Switch II region; other site
391904004494	G3 box; other site
391904004495	G4 box; other site
391904004496	G5 box; other site
391904004497	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
391904004498	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
391904004499	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
391904004500	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
391904004501	Histidine kinase; Region: HisKA_3; pfam07730
391904004502	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904004503	ATP binding site [chemical binding]; other site
391904004504	Mg2+ binding site [ion binding]; other site
391904004505	G-X-G motif; other site
391904004506	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904004507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904004508	active site
391904004509	phosphorylation site [posttranslational modification]
391904004510	intermolecular recognition site; other site
391904004511	dimerization interface [polypeptide binding]; other site
391904004512	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904004513	DNA binding residues [nucleotide binding]
391904004514	dimerization interface [polypeptide binding]; other site
391904004515	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904004516	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904004517	FtsX-like permease family; Region: FtsX; pfam02687
391904004518	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904004519	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904004520	Walker A/P-loop; other site
391904004521	ATP binding site [chemical binding]; other site
391904004522	Q-loop/lid; other site
391904004523	ABC transporter signature motif; other site
391904004524	Walker B; other site
391904004525	D-loop; other site
391904004526	H-loop/switch region; other site
391904004527	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
391904004528	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
391904004529	homodimer interface [polypeptide binding]; other site
391904004530	substrate-cofactor binding pocket; other site
391904004531	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904004532	catalytic residue [active]
391904004533	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
391904004534	dimer interface [polypeptide binding]; other site
391904004535	pyridoxal binding site [chemical binding]; other site
391904004536	ATP binding site [chemical binding]; other site
391904004537	hypothetical protein; Provisional; Region: PRK14681
391904004538	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
391904004539	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
391904004540	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904004541	Walker A motif; other site
391904004542	ATP binding site [chemical binding]; other site
391904004543	Walker B motif; other site
391904004544	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
391904004545	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
391904004546	DNA protecting protein DprA; Region: dprA; TIGR00732
391904004547	L-aspartate oxidase; Provisional; Region: PRK06175
391904004548	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
391904004549	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
391904004550	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
391904004551	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
391904004552	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
391904004553	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
391904004554	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
391904004555	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
391904004556	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
391904004557	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
391904004558	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904004559	Walker A motif; other site
391904004560	ATP binding site [chemical binding]; other site
391904004561	Walker B motif; other site
391904004562	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
391904004563	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
391904004564	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
391904004565	oligomer interface [polypeptide binding]; other site
391904004566	active site residues [active]
391904004567	Clp protease; Region: CLP_protease; pfam00574
391904004568	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
391904004569	oligomer interface [polypeptide binding]; other site
391904004570	active site residues [active]
391904004571	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
391904004572	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
391904004573	putative ion selectivity filter; other site
391904004574	putative pore gating glutamate residue; other site
391904004575	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
391904004576	dimer interface [polypeptide binding]; other site
391904004577	trigger factor; Provisional; Region: tig; PRK01490
391904004578	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
391904004579	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
391904004580	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
391904004581	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
391904004582	active site
391904004583	catalytic site [active]
391904004584	substrate binding site [chemical binding]; other site
391904004585	HRDC domain; Region: HRDC; pfam00570
391904004586	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
391904004587	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
391904004588	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391904004589	FeS/SAM binding site; other site
391904004590	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
391904004591	Pyruvate formate lyase 1; Region: PFL1; cd01678
391904004592	coenzyme A binding site [chemical binding]; other site
391904004593	active site
391904004594	catalytic residues [active]
391904004595	glycine loop; other site
391904004596	NAD synthetase; Provisional; Region: PRK13981
391904004597	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
391904004598	multimer interface [polypeptide binding]; other site
391904004599	active site
391904004600	catalytic triad [active]
391904004601	protein interface 1 [polypeptide binding]; other site
391904004602	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
391904004603	homodimer interface [polypeptide binding]; other site
391904004604	NAD binding pocket [chemical binding]; other site
391904004605	ATP binding pocket [chemical binding]; other site
391904004606	Mg binding site [ion binding]; other site
391904004607	active-site loop [active]
391904004608	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
391904004609	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
391904004610	metal binding site [ion binding]; metal-binding site
391904004611	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
391904004612	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
391904004613	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
391904004614	Walker A/P-loop; other site
391904004615	ATP binding site [chemical binding]; other site
391904004616	Q-loop/lid; other site
391904004617	ABC transporter signature motif; other site
391904004618	Walker B; other site
391904004619	D-loop; other site
391904004620	H-loop/switch region; other site
391904004621	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
391904004622	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
391904004623	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
391904004624	putative phosphoketolase; Provisional; Region: PRK05261
391904004625	XFP N-terminal domain; Region: XFP_N; pfam09364
391904004626	XFP C-terminal domain; Region: XFP_C; pfam09363
391904004627	GMP synthase; Reviewed; Region: guaA; PRK00074
391904004628	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
391904004629	AMP/PPi binding site [chemical binding]; other site
391904004630	candidate oxyanion hole; other site
391904004631	catalytic triad [active]
391904004632	potential glutamine specificity residues [chemical binding]; other site
391904004633	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
391904004634	ATP Binding subdomain [chemical binding]; other site
391904004635	Ligand Binding sites [chemical binding]; other site
391904004636	Dimerization subdomain; other site
391904004637	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
391904004638	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
391904004639	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
391904004640	catalytic triad [active]
391904004641	catalytic triad [active]
391904004642	oxyanion hole [active]
391904004643	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
391904004644	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
391904004645	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904004646	active site
391904004647	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
391904004648	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
391904004649	Substrate binding site; other site
391904004650	Mg++ binding site; other site
391904004651	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
391904004652	active site
391904004653	substrate binding site [chemical binding]; other site
391904004654	CoA binding site [chemical binding]; other site
391904004655	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
391904004656	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904004657	catalytic core [active]
391904004658	AAA domain; Region: AAA_26; pfam13500
391904004659	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
391904004660	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
391904004661	propionate/acetate kinase; Provisional; Region: PRK12379
391904004662	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
391904004663	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
391904004664	hinge; other site
391904004665	active site
391904004666	HNH endonuclease; Region: HNH; pfam01844
391904004667	active site
391904004668	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904004669	active site
391904004670	DNA binding site [nucleotide binding]
391904004671	Int/Topo IB signature motif; other site
391904004672	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
391904004673	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
391904004674	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
391904004675	active site
391904004676	catalytic site [active]
391904004677	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
391904004678	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
391904004679	dimer interface [polypeptide binding]; other site
391904004680	ADP-ribose binding site [chemical binding]; other site
391904004681	active site
391904004682	nudix motif; other site
391904004683	metal binding site [ion binding]; metal-binding site
391904004684	Uncharacterized conserved protein [Function unknown]; Region: COG0327
391904004685	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
391904004686	DNA polymerase I; Provisional; Region: PRK05755
391904004687	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
391904004688	active site
391904004689	metal binding site 1 [ion binding]; metal-binding site
391904004690	putative 5' ssDNA interaction site; other site
391904004691	metal binding site 3; metal-binding site
391904004692	metal binding site 2 [ion binding]; metal-binding site
391904004693	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
391904004694	putative DNA binding site [nucleotide binding]; other site
391904004695	putative metal binding site [ion binding]; other site
391904004696	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
391904004697	active site
391904004698	substrate binding site [chemical binding]; other site
391904004699	catalytic site [active]
391904004700	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
391904004701	active site
391904004702	DNA binding site [nucleotide binding]
391904004703	catalytic site [active]
391904004704	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
391904004705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904004706	active site
391904004707	phosphorylation site [posttranslational modification]
391904004708	intermolecular recognition site; other site
391904004709	dimerization interface [polypeptide binding]; other site
391904004710	ANTAR domain; Region: ANTAR; pfam03861
391904004711	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
391904004712	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
391904004713	domain interfaces; other site
391904004714	active site
391904004715	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
391904004716	excinuclease ABC subunit B; Provisional; Region: PRK05298
391904004717	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904004718	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904004719	nucleotide binding region [chemical binding]; other site
391904004720	ATP-binding site [chemical binding]; other site
391904004721	Ultra-violet resistance protein B; Region: UvrB; pfam12344
391904004722	UvrB/uvrC motif; Region: UVR; pfam02151
391904004723	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904004724	Response regulator receiver domain; Region: Response_reg; pfam00072
391904004725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904004726	active site
391904004727	phosphorylation site [posttranslational modification]
391904004728	intermolecular recognition site; other site
391904004729	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
391904004730	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904004731	DNA binding residues [nucleotide binding]
391904004732	dimerization interface [polypeptide binding]; other site
391904004733	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
391904004734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
391904004735	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904004736	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
391904004737	Walker A/P-loop; other site
391904004738	ATP binding site [chemical binding]; other site
391904004739	Q-loop/lid; other site
391904004740	ABC transporter signature motif; other site
391904004741	Walker B; other site
391904004742	D-loop; other site
391904004743	H-loop/switch region; other site
391904004744	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
391904004745	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
391904004746	CoA-binding site [chemical binding]; other site
391904004747	ATP-binding [chemical binding]; other site
391904004748	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
391904004749	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
391904004750	RNA binding site [nucleotide binding]; other site
391904004751	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
391904004752	RNA binding site [nucleotide binding]; other site
391904004753	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
391904004754	RNA binding site [nucleotide binding]; other site
391904004755	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
391904004756	RNA binding site [nucleotide binding]; other site
391904004757	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
391904004758	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
391904004759	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
391904004760	homodimer interface [polypeptide binding]; other site
391904004761	NADP binding site [chemical binding]; other site
391904004762	substrate binding site [chemical binding]; other site
391904004763	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
391904004764	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
391904004765	metal binding site [ion binding]; metal-binding site
391904004766	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
391904004767	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
391904004768	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
391904004769	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
391904004770	ABC-ATPase subunit  interface; other site
391904004771	dimer interface [polypeptide binding]; other site
391904004772	putative PBP binding regions; other site
391904004773	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
391904004774	homotrimer interaction site [polypeptide binding]; other site
391904004775	zinc binding site [ion binding]; other site
391904004776	CDP-binding sites; other site
391904004777	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
391904004778	glycogen branching enzyme; Provisional; Region: PRK05402
391904004779	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
391904004780	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
391904004781	active site
391904004782	catalytic site [active]
391904004783	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
391904004784	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904004785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904004786	active site
391904004787	phosphorylation site [posttranslational modification]
391904004788	intermolecular recognition site; other site
391904004789	dimerization interface [polypeptide binding]; other site
391904004790	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391904004791	DNA binding site [nucleotide binding]
391904004792	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391904004793	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
391904004794	dimerization interface [polypeptide binding]; other site
391904004795	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391904004796	dimer interface [polypeptide binding]; other site
391904004797	phosphorylation site [posttranslational modification]
391904004798	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904004799	ATP binding site [chemical binding]; other site
391904004800	Mg2+ binding site [ion binding]; other site
391904004801	G-X-G motif; other site
391904004802	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
391904004803	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904004804	active site
391904004805	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
391904004806	Eukaryotic phosphomannomutase; Region: PMM; cl17107
391904004807	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
391904004808	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
391904004809	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391904004810	Transcription factor WhiB; Region: Whib; pfam02467
391904004811	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
391904004812	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
391904004813	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
391904004814	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
391904004815	Transcription factor WhiB; Region: Whib; pfam02467
391904004816	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
391904004817	PAS fold; Region: PAS_4; pfam08448
391904004818	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
391904004819	Histidine kinase; Region: HisKA_2; pfam07568
391904004820	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
391904004821	Mg2+ binding site [ion binding]; other site
391904004822	Haemolysin-III related; Region: HlyIII; pfam03006
391904004823	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
391904004824	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
391904004825	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
391904004826	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
391904004827	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
391904004828	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
391904004829	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
391904004830	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
391904004831	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
391904004832	active site
391904004833	Int/Topo IB signature motif; other site
391904004834	catalytic residues [active]
391904004835	DNA binding site [nucleotide binding]
391904004836	Fic family protein [Function unknown]; Region: COG3177
391904004837	Fic/DOC family; Region: Fic; pfam02661
391904004838	Uncharacterized conserved protein [Function unknown]; Region: COG4748
391904004839	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
391904004840	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904004841	non-specific DNA binding site [nucleotide binding]; other site
391904004842	salt bridge; other site
391904004843	sequence-specific DNA binding site [nucleotide binding]; other site
391904004844	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
391904004845	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
391904004846	dimer interface [polypeptide binding]; other site
391904004847	ssDNA binding site [nucleotide binding]; other site
391904004848	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904004849	ParB-like nuclease domain; Region: ParB; smart00470
391904004850	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
391904004851	Helix-turn-helix domain; Region: HTH_36; pfam13730
391904004852	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
391904004853	active site
391904004854	catalytic site [active]
391904004855	substrate binding site [chemical binding]; other site
391904004856	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
391904004857	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
391904004858	Phage Terminase; Region: Terminase_1; pfam03354
391904004859	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
391904004860	Phage capsid family; Region: Phage_capsid; pfam05065
391904004861	Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355
391904004862	Phage-related minor tail protein [Function unknown]; Region: COG5280
391904004863	tape measure domain; Region: tape_meas_nterm; TIGR02675
391904004864	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
391904004865	Interdomain contacts; other site
391904004866	Cytokine receptor motif; other site
391904004867	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
391904004868	LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.  The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417
391904004869	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
391904004870	active site
391904004871	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; pfam08230
391904004872	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
391904004873	exopolyphosphatase; Region: exo_poly_only; TIGR03706
391904004874	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
391904004875	Protein of unknown function (DUF501); Region: DUF501; pfam04417
391904004876	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
391904004877	Septum formation initiator; Region: DivIC; pfam04977
391904004878	enolase; Provisional; Region: eno; PRK00077
391904004879	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
391904004880	dimer interface [polypeptide binding]; other site
391904004881	metal binding site [ion binding]; metal-binding site
391904004882	substrate binding pocket [chemical binding]; other site
391904004883	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904004884	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
391904004885	active site
391904004886	catalytic tetrad [active]
391904004887	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
391904004888	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
391904004889	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904004890	ATP binding site [chemical binding]; other site
391904004891	putative Mg++ binding site [ion binding]; other site
391904004892	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904004893	nucleotide binding region [chemical binding]; other site
391904004894	ATP-binding site [chemical binding]; other site
391904004895	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
391904004896	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
391904004897	putative active site [active]
391904004898	catalytic residue [active]
391904004899	Large family of predicted nucleotide-binding domains; Region: PINc; smart00670
391904004900	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
391904004901	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904004902	Coenzyme A binding pocket [chemical binding]; other site
391904004903	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
391904004904	Uncharacterized conserved protein [Function unknown]; Region: COG1615
391904004905	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
391904004906	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
391904004907	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
391904004908	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
391904004909	active site
391904004910	(T/H)XGH motif; other site
391904004911	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
391904004912	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
391904004913	putative catalytic cysteine [active]
391904004914	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
391904004915	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
391904004916	dimer interface [polypeptide binding]; other site
391904004917	active site
391904004918	glycine-pyridoxal phosphate binding site [chemical binding]; other site
391904004919	folate binding site [chemical binding]; other site
391904004920	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
391904004921	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
391904004922	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904004923	catalytic residue [active]
391904004924	Predicted membrane protein [General function prediction only]; Region: COG4194
391904004925	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
391904004926	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
391904004927	DNA-binding site [nucleotide binding]; DNA binding site
391904004928	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
391904004929	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
391904004930	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904004931	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391904004932	Walker A/P-loop; other site
391904004933	ATP binding site [chemical binding]; other site
391904004934	Q-loop/lid; other site
391904004935	ABC transporter signature motif; other site
391904004936	Walker B; other site
391904004937	D-loop; other site
391904004938	H-loop/switch region; other site
391904004939	Predicted transcriptional regulators [Transcription]; Region: COG1725
391904004940	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
391904004941	DNA-binding site [nucleotide binding]; DNA binding site
391904004942	Histidine kinase; Region: HisKA_3; pfam07730
391904004943	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904004944	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904004945	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
391904004946	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
391904004947	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904004948	motif II; other site
391904004949	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
391904004950	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
391904004951	Walker A/P-loop; other site
391904004952	ATP binding site [chemical binding]; other site
391904004953	Q-loop/lid; other site
391904004954	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
391904004955	ABC transporter signature motif; other site
391904004956	Walker B; other site
391904004957	D-loop; other site
391904004958	H-loop/switch region; other site
391904004959	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
391904004960	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
391904004961	Protein of unknown function (DUF342); Region: DUF342; pfam03961
391904004962	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
391904004963	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391904004964	RNA binding surface [nucleotide binding]; other site
391904004965	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904004966	S-adenosylmethionine binding site [chemical binding]; other site
391904004967	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
391904004968	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
391904004969	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
391904004970	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
391904004971	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
391904004972	active site
391904004973	HIGH motif; other site
391904004974	dimer interface [polypeptide binding]; other site
391904004975	KMSKS motif; other site
391904004976	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391904004977	RNA binding surface [nucleotide binding]; other site
391904004978	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
391904004979	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
391904004980	Zn2+ binding site [ion binding]; other site
391904004981	Mg2+ binding site [ion binding]; other site
391904004982	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
391904004983	active site residue [active]
391904004984	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
391904004985	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
391904004986	ATP binding site [chemical binding]; other site
391904004987	substrate interface [chemical binding]; other site
391904004988	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
391904004989	ThiS interaction site; other site
391904004990	putative active site [active]
391904004991	tetramer interface [polypeptide binding]; other site
391904004992	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
391904004993	thiS-thiF/thiG interaction site; other site
391904004994	argininosuccinate lyase; Provisional; Region: PRK00855
391904004995	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
391904004996	active sites [active]
391904004997	tetramer interface [polypeptide binding]; other site
391904004998	argininosuccinate synthase; Provisional; Region: PRK13820
391904004999	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
391904005000	ANP binding site [chemical binding]; other site
391904005001	Substrate Binding Site II [chemical binding]; other site
391904005002	Substrate Binding Site I [chemical binding]; other site
391904005003	arginine repressor; Provisional; Region: PRK03341
391904005004	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
391904005005	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
391904005006	ornithine carbamoyltransferase; Provisional; Region: PRK00779
391904005007	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
391904005008	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
391904005009	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
391904005010	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
391904005011	inhibitor-cofactor binding pocket; inhibition site
391904005012	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904005013	catalytic residue [active]
391904005014	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
391904005015	feedback inhibition sensing region; other site
391904005016	homohexameric interface [polypeptide binding]; other site
391904005017	nucleotide binding site [chemical binding]; other site
391904005018	N-acetyl-L-glutamate binding site [chemical binding]; other site
391904005019	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
391904005020	heterotetramer interface [polypeptide binding]; other site
391904005021	active site pocket [active]
391904005022	cleavage site
391904005023	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
391904005024	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
391904005025	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
391904005026	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
391904005027	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
391904005028	putative tRNA-binding site [nucleotide binding]; other site
391904005029	B3/4 domain; Region: B3_4; pfam03483
391904005030	tRNA synthetase B5 domain; Region: B5; pfam03484
391904005031	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
391904005032	dimer interface [polypeptide binding]; other site
391904005033	motif 1; other site
391904005034	motif 3; other site
391904005035	motif 2; other site
391904005036	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
391904005037	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
391904005038	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
391904005039	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
391904005040	dimer interface [polypeptide binding]; other site
391904005041	motif 1; other site
391904005042	active site
391904005043	motif 2; other site
391904005044	motif 3; other site
391904005045	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
391904005046	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
391904005047	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
391904005048	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
391904005049	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
391904005050	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
391904005051	Walker A/P-loop; other site
391904005052	ATP binding site [chemical binding]; other site
391904005053	Q-loop/lid; other site
391904005054	ABC transporter signature motif; other site
391904005055	Walker B; other site
391904005056	D-loop; other site
391904005057	H-loop/switch region; other site
391904005058	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
391904005059	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
391904005060	Walker A/P-loop; other site
391904005061	ATP binding site [chemical binding]; other site
391904005062	Q-loop/lid; other site
391904005063	ABC transporter signature motif; other site
391904005064	Walker B; other site
391904005065	D-loop; other site
391904005066	H-loop/switch region; other site
391904005067	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
391904005068	hypothetical protein; Provisional; Region: PRK07907
391904005069	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
391904005070	active site
391904005071	metal binding site [ion binding]; metal-binding site
391904005072	dimer interface [polypeptide binding]; other site
391904005073	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
391904005074	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
391904005075	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
391904005076	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391904005077	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
391904005078	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
391904005079	glutamine synthetase, type I; Region: GlnA; TIGR00653
391904005080	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
391904005081	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
391904005082	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
391904005083	Membrane transport protein; Region: Mem_trans; cl09117
391904005084	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
391904005085	putative trimer interface [polypeptide binding]; other site
391904005086	Predicted transcriptional regulators [Transcription]; Region: COG1695
391904005087	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
391904005088	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
391904005089	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
391904005090	minor groove reading motif; other site
391904005091	helix-hairpin-helix signature motif; other site
391904005092	substrate binding pocket [chemical binding]; other site
391904005093	active site
391904005094	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
391904005095	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
391904005096	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005097	Walker A/P-loop; other site
391904005098	ATP binding site [chemical binding]; other site
391904005099	Q-loop/lid; other site
391904005100	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005101	ABC transporter signature motif; other site
391904005102	Walker B; other site
391904005103	D-loop; other site
391904005104	H-loop/switch region; other site
391904005105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005106	Walker A/P-loop; other site
391904005107	ATP binding site [chemical binding]; other site
391904005108	Q-loop/lid; other site
391904005109	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
391904005110	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005111	ABC transporter signature motif; other site
391904005112	Walker B; other site
391904005113	D-loop; other site
391904005114	H-loop/switch region; other site
391904005115	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
391904005116	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
391904005117	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
391904005118	beta-galactosidase; Region: BGL; TIGR03356
391904005119	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
391904005120	active site
391904005121	catalytic triad [active]
391904005122	oxyanion hole [active]
391904005123	Domain of unknown function (DUF303); Region: DUF303; pfam03629
391904005124	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391904005125	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391904005126	dimer interface [polypeptide binding]; other site
391904005127	phosphorylation site [posttranslational modification]
391904005128	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904005129	ATP binding site [chemical binding]; other site
391904005130	Mg2+ binding site [ion binding]; other site
391904005131	G-X-G motif; other site
391904005132	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904005133	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904005134	Winged helix-turn helix; Region: HTH_29; pfam13551
391904005135	putative transposase OrfB; Reviewed; Region: PHA02517
391904005136	HTH-like domain; Region: HTH_21; pfam13276
391904005137	Integrase core domain; Region: rve; pfam00665
391904005138	Integrase core domain; Region: rve_2; pfam13333
391904005139	AAA domain; Region: AAA_14; pfam13173
391904005140	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904005141	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904005142	FtsX-like permease family; Region: FtsX; pfam02687
391904005143	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904005144	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904005145	Walker A/P-loop; other site
391904005146	ATP binding site [chemical binding]; other site
391904005147	Q-loop/lid; other site
391904005148	ABC transporter signature motif; other site
391904005149	Walker B; other site
391904005150	D-loop; other site
391904005151	H-loop/switch region; other site
391904005152	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904005153	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904005154	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904005155	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
391904005156	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
391904005157	catalytic Zn binding site [ion binding]; other site
391904005158	NAD(P) binding site [chemical binding]; other site
391904005159	structural Zn binding site [ion binding]; other site
391904005160	potential frameshift: common BLAST hit: gi|283456003|ref|YP_003360567.1| MerR family transcriptional regulator
391904005161	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
391904005162	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
391904005163	DNA binding residues [nucleotide binding]
391904005164	CrcB-like protein; Region: CRCB; pfam02537
391904005165	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
391904005166	Predicted membrane protein [Function unknown]; Region: COG2246
391904005167	GtrA-like protein; Region: GtrA; pfam04138
391904005168	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
391904005169	potential frameshift: common BLAST hit: gi|312133108|ref|YP_004000447.1| lysr
391904005170	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
391904005171	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
391904005172	dimerization interface [polypeptide binding]; other site
391904005173	elongation factor Tu; Reviewed; Region: PRK00049
391904005174	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
391904005175	G1 box; other site
391904005176	GEF interaction site [polypeptide binding]; other site
391904005177	GTP/Mg2+ binding site [chemical binding]; other site
391904005178	Switch I region; other site
391904005179	G2 box; other site
391904005180	G3 box; other site
391904005181	Switch II region; other site
391904005182	G4 box; other site
391904005183	G5 box; other site
391904005184	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
391904005185	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
391904005186	Antibiotic Binding Site [chemical binding]; other site
391904005187	elongation factor G; Reviewed; Region: PRK00007
391904005188	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
391904005189	G1 box; other site
391904005190	putative GEF interaction site [polypeptide binding]; other site
391904005191	GTP/Mg2+ binding site [chemical binding]; other site
391904005192	Switch I region; other site
391904005193	G2 box; other site
391904005194	G3 box; other site
391904005195	Switch II region; other site
391904005196	G4 box; other site
391904005197	G5 box; other site
391904005198	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
391904005199	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
391904005200	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
391904005201	30S ribosomal protein S7; Validated; Region: PRK05302
391904005202	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
391904005203	S17 interaction site [polypeptide binding]; other site
391904005204	S8 interaction site; other site
391904005205	16S rRNA interaction site [nucleotide binding]; other site
391904005206	streptomycin interaction site [chemical binding]; other site
391904005207	23S rRNA interaction site [nucleotide binding]; other site
391904005208	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
391904005209	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904005210	Abi-like protein; Region: Abi_2; pfam07751
391904005211	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904005212	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904005213	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904005214	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904005215	non-specific DNA binding site [nucleotide binding]; other site
391904005216	salt bridge; other site
391904005217	sequence-specific DNA binding site [nucleotide binding]; other site
391904005218	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
391904005219	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904005220	Walker A motif; other site
391904005221	ATP binding site [chemical binding]; other site
391904005222	Walker B motif; other site
391904005223	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904005224	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904005225	Winged helix-turn helix; Region: HTH_29; pfam13551
391904005226	putative transposase OrfB; Reviewed; Region: PHA02517
391904005227	HTH-like domain; Region: HTH_21; pfam13276
391904005228	Integrase core domain; Region: rve; pfam00665
391904005229	Integrase core domain; Region: rve_2; pfam13333
391904005230	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
391904005231	Sodium Bile acid symporter family; Region: SBF; pfam01758
391904005232	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
391904005233	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
391904005234	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904005235	catalytic residue [active]
391904005236	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
391904005237	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391904005238	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
391904005239	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904005240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904005241	homodimer interface [polypeptide binding]; other site
391904005242	catalytic residue [active]
391904005243	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
391904005244	ATP-grasp domain; Region: ATP-grasp; pfam02222
391904005245	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
391904005246	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
391904005247	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
391904005248	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
391904005249	ATP binding site [chemical binding]; other site
391904005250	active site
391904005251	substrate binding site [chemical binding]; other site
391904005252	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
391904005253	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
391904005254	dimerization interface [polypeptide binding]; other site
391904005255	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
391904005256	dimerization interface [polypeptide binding]; other site
391904005257	ATP binding site [chemical binding]; other site
391904005258	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
391904005259	dimerization interface [polypeptide binding]; other site
391904005260	ATP binding site [chemical binding]; other site
391904005261	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
391904005262	putative active site [active]
391904005263	catalytic triad [active]
391904005264	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
391904005265	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
391904005266	putative active site [active]
391904005267	HipA N-terminal domain; Region: Couple_hipA; pfam13657
391904005268	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
391904005269	HipA-like N-terminal domain; Region: HipA_N; pfam07805
391904005270	HipA-like C-terminal domain; Region: HipA_C; pfam07804
391904005271	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904005272	non-specific DNA binding site [nucleotide binding]; other site
391904005273	salt bridge; other site
391904005274	sequence-specific DNA binding site [nucleotide binding]; other site
391904005275	potential frameshift: common BLAST hit: gi|312133126|ref|YP_004000465.1| tas2
391904005276	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
391904005277	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904005278	DNA polymerase IV; Reviewed; Region: PRK03103
391904005279	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
391904005280	active site
391904005281	DNA binding site [nucleotide binding]
391904005282	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
391904005283	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
391904005284	NAD binding site [chemical binding]; other site
391904005285	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
391904005286	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312
391904005287	active site
391904005288	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
391904005289	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904005290	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391904005291	substrate binding pocket [chemical binding]; other site
391904005292	membrane-bound complex binding site; other site
391904005293	hinge residues; other site
391904005294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005295	dimer interface [polypeptide binding]; other site
391904005296	conserved gate region; other site
391904005297	putative PBP binding loops; other site
391904005298	ABC-ATPase subunit interface; other site
391904005299	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391904005300	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
391904005301	Walker A/P-loop; other site
391904005302	ATP binding site [chemical binding]; other site
391904005303	Q-loop/lid; other site
391904005304	ABC transporter signature motif; other site
391904005305	Walker B; other site
391904005306	D-loop; other site
391904005307	H-loop/switch region; other site
391904005308	amidophosphoribosyltransferase; Provisional; Region: PRK07272
391904005309	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
391904005310	active site
391904005311	tetramer interface [polypeptide binding]; other site
391904005312	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904005313	active site
391904005314	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
391904005315	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
391904005316	dimerization interface [polypeptide binding]; other site
391904005317	putative ATP binding site [chemical binding]; other site
391904005318	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
391904005319	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
391904005320	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
391904005321	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
391904005322	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
391904005323	NAD(P) binding site [chemical binding]; other site
391904005324	catalytic residues [active]
391904005325	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
391904005326	Sulfatase; Region: Sulfatase; pfam00884
391904005327	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
391904005328	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
391904005329	metal binding site [ion binding]; metal-binding site
391904005330	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
391904005331	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
391904005332	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
391904005333	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
391904005334	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
391904005335	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
391904005336	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
391904005337	Predicted permease; Region: DUF318; cl17795
391904005338	TIGR03943 family protein; Region: TIGR03943
391904005339	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
391904005340	metal binding site 2 [ion binding]; metal-binding site
391904005341	putative DNA binding helix; other site
391904005342	metal binding site 1 [ion binding]; metal-binding site
391904005343	dimer interface [polypeptide binding]; other site
391904005344	structural Zn2+ binding site [ion binding]; other site
391904005345	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005346	Q-loop/lid; other site
391904005347	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
391904005348	metal binding site 2 [ion binding]; metal-binding site
391904005349	putative DNA binding helix; other site
391904005350	metal binding site 1 [ion binding]; metal-binding site
391904005351	dimer interface [polypeptide binding]; other site
391904005352	structural Zn2+ binding site [ion binding]; other site
391904005353	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
391904005354	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
391904005355	NAD binding site [chemical binding]; other site
391904005356	ATP-grasp domain; Region: ATP-grasp; pfam02222
391904005357	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
391904005358	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
391904005359	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
391904005360	NAD(P) binding site [chemical binding]; other site
391904005361	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
391904005362	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
391904005363	TPP-binding site; other site
391904005364	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
391904005365	PYR/PP interface [polypeptide binding]; other site
391904005366	dimer interface [polypeptide binding]; other site
391904005367	TPP binding site [chemical binding]; other site
391904005368	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
391904005369	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904005370	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904005371	FtsX-like permease family; Region: FtsX; pfam02687
391904005372	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
391904005373	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904005374	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904005375	Walker A/P-loop; other site
391904005376	ATP binding site [chemical binding]; other site
391904005377	Q-loop/lid; other site
391904005378	ABC transporter signature motif; other site
391904005379	Walker B; other site
391904005380	D-loop; other site
391904005381	H-loop/switch region; other site
391904005382	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
391904005383	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
391904005384	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
391904005385	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
391904005386	putative active site [active]
391904005387	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
391904005388	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
391904005389	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
391904005390	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
391904005391	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
391904005392	DNA-binding site [nucleotide binding]; DNA binding site
391904005393	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904005394	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904005395	homodimer interface [polypeptide binding]; other site
391904005396	catalytic residue [active]
391904005397	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
391904005398	predicted active site [active]
391904005399	catalytic triad [active]
391904005400	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
391904005401	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
391904005402	active site
391904005403	multimer interface [polypeptide binding]; other site
391904005404	DNA primase, catalytic core; Region: dnaG; TIGR01391
391904005405	CHC2 zinc finger; Region: zf-CHC2; cl17510
391904005406	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
391904005407	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
391904005408	active site
391904005409	metal binding site [ion binding]; metal-binding site
391904005410	interdomain interaction site; other site
391904005411	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
391904005412	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
391904005413	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
391904005414	Zn2+ binding site [ion binding]; other site
391904005415	Mg2+ binding site [ion binding]; other site
391904005416	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
391904005417	alanine racemase; Reviewed; Region: alr; PRK00053
391904005418	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
391904005419	active site
391904005420	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
391904005421	dimer interface [polypeptide binding]; other site
391904005422	substrate binding site [chemical binding]; other site
391904005423	catalytic residues [active]
391904005424	amino acid transporter; Region: 2A0306; TIGR00909
391904005425	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
391904005426	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
391904005427	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
391904005428	S-ribosylhomocysteinase; Provisional; Region: PRK02260
391904005429	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
391904005430	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904005431	ATP binding site [chemical binding]; other site
391904005432	putative Mg++ binding site [ion binding]; other site
391904005433	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904005434	nucleotide binding region [chemical binding]; other site
391904005435	ATP-binding site [chemical binding]; other site
391904005436	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
391904005437	HRDC domain; Region: HRDC; pfam00570
391904005438	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
391904005439	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
391904005440	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
391904005441	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904005442	catalytic residue [active]
391904005443	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
391904005444	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
391904005445	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904005446	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904005447	putative substrate translocation pore; other site
391904005448	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904005449	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
391904005450	active site
391904005451	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
391904005452	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904005453	Walker A/P-loop; other site
391904005454	ATP binding site [chemical binding]; other site
391904005455	Q-loop/lid; other site
391904005456	ABC transporter signature motif; other site
391904005457	Walker B; other site
391904005458	D-loop; other site
391904005459	H-loop/switch region; other site
391904005460	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
391904005461	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904005462	Walker A/P-loop; other site
391904005463	ATP binding site [chemical binding]; other site
391904005464	Q-loop/lid; other site
391904005465	ABC transporter signature motif; other site
391904005466	Walker B; other site
391904005467	D-loop; other site
391904005468	H-loop/switch region; other site
391904005469	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904005470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005471	dimer interface [polypeptide binding]; other site
391904005472	conserved gate region; other site
391904005473	putative PBP binding loops; other site
391904005474	ABC-ATPase subunit interface; other site
391904005475	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904005476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005477	dimer interface [polypeptide binding]; other site
391904005478	conserved gate region; other site
391904005479	putative PBP binding loops; other site
391904005480	ABC-ATPase subunit interface; other site
391904005481	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
391904005482	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
391904005483	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
391904005484	Flavoprotein; Region: Flavoprotein; pfam02441
391904005485	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
391904005486	pantothenate kinase; Reviewed; Region: PRK13318
391904005487	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904005488	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904005489	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
391904005490	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
391904005491	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
391904005492	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
391904005493	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
391904005494	active site
391904005495	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
391904005496	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
391904005497	glutaminase active site [active]
391904005498	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
391904005499	dimer interface [polypeptide binding]; other site
391904005500	active site
391904005501	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
391904005502	dimer interface [polypeptide binding]; other site
391904005503	active site
391904005504	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391904005505	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
391904005506	Walker A/P-loop; other site
391904005507	ATP binding site [chemical binding]; other site
391904005508	Q-loop/lid; other site
391904005509	ABC transporter signature motif; other site
391904005510	Walker B; other site
391904005511	D-loop; other site
391904005512	H-loop/switch region; other site
391904005513	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005514	dimer interface [polypeptide binding]; other site
391904005515	conserved gate region; other site
391904005516	ABC-ATPase subunit interface; other site
391904005517	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904005518	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391904005519	substrate binding pocket [chemical binding]; other site
391904005520	membrane-bound complex binding site; other site
391904005521	hinge residues; other site
391904005522	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904005523	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391904005524	substrate binding pocket [chemical binding]; other site
391904005525	membrane-bound complex binding site; other site
391904005526	hinge residues; other site
391904005527	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
391904005528	SmpB-tmRNA interface; other site
391904005529	Surface antigen [General function prediction only]; Region: COG3942
391904005530	CHAP domain; Region: CHAP; pfam05257
391904005531	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
391904005532	FtsX-like permease family; Region: FtsX; pfam02687
391904005533	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
391904005534	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005535	Walker A/P-loop; other site
391904005536	ATP binding site [chemical binding]; other site
391904005537	Q-loop/lid; other site
391904005538	ABC transporter signature motif; other site
391904005539	Walker B; other site
391904005540	D-loop; other site
391904005541	H-loop/switch region; other site
391904005542	peptide chain release factor 2; Validated; Region: prfB; PRK00578
391904005543	This domain is found in peptide chain release factors; Region: PCRF; smart00937
391904005544	RF-1 domain; Region: RF-1; pfam00472
391904005545	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904005546	AAA domain; Region: AAA_14; pfam13173
391904005547	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904005548	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
391904005549	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
391904005550	active site
391904005551	substrate binding site [chemical binding]; other site
391904005552	catalytic site [active]
391904005553	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
391904005554	active site
391904005555	catalytic residues [active]
391904005556	metal binding site [ion binding]; metal-binding site
391904005557	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
391904005558	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
391904005559	active site
391904005560	substrate binding site [chemical binding]; other site
391904005561	metal binding site [ion binding]; metal-binding site
391904005562	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
391904005563	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
391904005564	Zn binding site [ion binding]; other site
391904005565	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
391904005566	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
391904005567	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
391904005568	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
391904005569	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
391904005570	dimer interface [polypeptide binding]; other site
391904005571	active site
391904005572	catalytic residue [active]
391904005573	dihydrodipicolinate reductase; Provisional; Region: PRK00048
391904005574	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
391904005575	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
391904005576	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904005577	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904005578	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
391904005579	Part of AAA domain; Region: AAA_19; pfam13245
391904005580	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
391904005581	Family description; Region: UvrD_C_2; pfam13538
391904005582	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904005583	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904005584	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904005585	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
391904005586	Catalytic domain of Protein Kinases; Region: PKc; cd00180
391904005587	active site
391904005588	ATP binding site [chemical binding]; other site
391904005589	substrate binding site [chemical binding]; other site
391904005590	activation loop (A-loop); other site
391904005591	potential frameshift: common BLAST hit: gi|296453648|ref|YP_003660791.1| fibronectin type III domain-containing protein
391904005592	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
391904005593	Interdomain contacts; other site
391904005594	Cytokine receptor motif; other site
391904005595	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
391904005596	Interdomain contacts; other site
391904005597	Cytokine receptor motif; other site
391904005598	MoxR-like ATPases [General function prediction only]; Region: COG0714
391904005599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904005600	Walker A motif; other site
391904005601	ATP binding site [chemical binding]; other site
391904005602	Walker B motif; other site
391904005603	arginine finger; other site
391904005604	Protein of unknown function DUF58; Region: DUF58; pfam01882
391904005605	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
391904005606	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
391904005607	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
391904005608	phosphopeptide binding site; other site
391904005609	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
391904005610	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
391904005611	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
391904005612	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
391904005613	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
391904005614	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
391904005615	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
391904005616	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
391904005617	DNA binding site [nucleotide binding]
391904005618	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
391904005619	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
391904005620	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
391904005621	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
391904005622	RPB1 interaction site [polypeptide binding]; other site
391904005623	RPB10 interaction site [polypeptide binding]; other site
391904005624	RPB11 interaction site [polypeptide binding]; other site
391904005625	RPB3 interaction site [polypeptide binding]; other site
391904005626	RPB12 interaction site [polypeptide binding]; other site
391904005627	Alphaherpesvirus tegument protein US9; Region: Herpes_US9; pfam06072
391904005628	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
391904005629	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
391904005630	minor groove reading motif; other site
391904005631	helix-hairpin-helix signature motif; other site
391904005632	active site
391904005633	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
391904005634	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
391904005635	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
391904005636	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
391904005637	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
391904005638	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
391904005639	substrate binding [chemical binding]; other site
391904005640	active site
391904005641	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904005642	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904005643	DNA binding site [nucleotide binding]
391904005644	domain linker motif; other site
391904005645	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
391904005646	putative dimerization interface [polypeptide binding]; other site
391904005647	putative ligand binding site [chemical binding]; other site
391904005648	Protein of unknown function, DUF624; Region: DUF624; cl02369
391904005649	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904005650	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005651	dimer interface [polypeptide binding]; other site
391904005652	conserved gate region; other site
391904005653	putative PBP binding loops; other site
391904005654	ABC-ATPase subunit interface; other site
391904005655	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
391904005656	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005657	dimer interface [polypeptide binding]; other site
391904005658	conserved gate region; other site
391904005659	putative PBP binding loops; other site
391904005660	ABC-ATPase subunit interface; other site
391904005661	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904005662	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
391904005663	galactokinase; Provisional; Region: PRK05322
391904005664	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
391904005665	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
391904005666	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
391904005667	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
391904005668	dimer interface [polypeptide binding]; other site
391904005669	active site
391904005670	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
391904005671	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
391904005672	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
391904005673	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
391904005674	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
391904005675	quinone interaction residues [chemical binding]; other site
391904005676	active site
391904005677	catalytic residues [active]
391904005678	FMN binding site [chemical binding]; other site
391904005679	substrate binding site [chemical binding]; other site
391904005680	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
391904005681	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
391904005682	active site
391904005683	FMN binding site [chemical binding]; other site
391904005684	substrate binding site [chemical binding]; other site
391904005685	homotetramer interface [polypeptide binding]; other site
391904005686	catalytic residue [active]
391904005687	Transglycosylase; Region: Transgly; pfam00912
391904005688	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
391904005689	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
391904005690	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
391904005691	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
391904005692	ligand binding site [chemical binding]; other site
391904005693	flexible hinge region; other site
391904005694	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
391904005695	putative switch regulator; other site
391904005696	non-specific DNA interactions [nucleotide binding]; other site
391904005697	DNA binding site [nucleotide binding]
391904005698	sequence specific DNA binding site [nucleotide binding]; other site
391904005699	putative cAMP binding site [chemical binding]; other site
391904005700	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
391904005701	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
391904005702	tartrate dehydrogenase; Region: TTC; TIGR02089
391904005703	Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897
391904005704	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
391904005705	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391904005706	Uncharacterized conserved protein [Function unknown]; Region: COG4850
391904005707	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
391904005708	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
391904005709	lipoyl attachment site [posttranslational modification]; other site
391904005710	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
391904005711	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
391904005712	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
391904005713	putative NADH binding site [chemical binding]; other site
391904005714	putative active site [active]
391904005715	nudix motif; other site
391904005716	putative metal binding site [ion binding]; other site
391904005717	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391904005718	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
391904005719	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
391904005720	catalytic residues [active]
391904005721	Domain of unknown function (DUF348); Region: DUF348; pfam03990
391904005722	G5 domain; Region: G5; pfam07501
391904005723	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
391904005724	N-acetyl-D-glucosamine binding site [chemical binding]; other site
391904005725	catalytic residue [active]
391904005726	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904005727	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904005728	non-specific DNA binding site [nucleotide binding]; other site
391904005729	salt bridge; other site
391904005730	sequence-specific DNA binding site [nucleotide binding]; other site
391904005731	HipA N-terminal domain; Region: Couple_hipA; pfam13657
391904005732	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
391904005733	HipA-like N-terminal domain; Region: HipA_N; pfam07805
391904005734	HipA-like C-terminal domain; Region: HipA_C; pfam07804
391904005735	Chain length determinant protein; Region: Wzz; cl15801
391904005736	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
391904005737	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
391904005738	Nucleotide binding site [chemical binding]; other site
391904005739	DTAP/Switch II; other site
391904005740	Switch I; other site
391904005741	Integrase core domain; Region: rve; pfam00665
391904005742	Abi-like protein; Region: Abi_2; pfam07751
391904005743	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904005744	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904005745	Integrase core domain; Region: rve; pfam00665
391904005746	Acyltransferase family; Region: Acyl_transf_3; pfam01757
391904005747	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904005748	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904005749	non-specific DNA binding site [nucleotide binding]; other site
391904005750	salt bridge; other site
391904005751	sequence-specific DNA binding site [nucleotide binding]; other site
391904005752	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
391904005753	Winged helix-turn helix; Region: HTH_29; pfam13551
391904005754	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904005755	potential frameshift: common BLAST hit: gi|311063507|ref|YP_003970232.1| IS21 family transposase
391904005756	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
391904005757	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904005758	sequence-specific DNA binding site [nucleotide binding]; other site
391904005759	salt bridge; other site
391904005760	Integrase core domain; Region: rve; pfam00665
391904005761	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904005762	Walker A motif; other site
391904005763	ATP binding site [chemical binding]; other site
391904005764	Walker B motif; other site
391904005765	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904005766	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904005767	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904005768	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904005769	non-specific DNA binding site [nucleotide binding]; other site
391904005770	salt bridge; other site
391904005771	sequence-specific DNA binding site [nucleotide binding]; other site
391904005772	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
391904005773	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
391904005774	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
391904005775	Transposase, Mutator family; Region: Transposase_mut; pfam00872
391904005776	MULE transposase domain; Region: MULE; pfam10551
391904005777	Core-2/I-Branching enzyme; Region: Branch; pfam02485
391904005778	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
391904005779	putative glycosyl transferase; Provisional; Region: PRK10073
391904005780	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391904005781	active site
391904005782	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391904005783	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
391904005784	putative ADP-binding pocket [chemical binding]; other site
391904005785	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
391904005786	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391904005787	active site
391904005788	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
391904005789	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904005790	Low molecular weight phosphatase family; Region: LMWPc; cl00105
391904005791	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904005792	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904005793	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904005794	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
391904005795	Bacterial sugar transferase; Region: Bac_transf; pfam02397
391904005796	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
391904005797	Divergent AAA domain; Region: AAA_4; pfam04326
391904005798	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
391904005799	Transposase; Region: DDE_Tnp_ISL3; pfam01610
391904005800	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
391904005801	AAA ATPase domain; Region: AAA_16; pfam13191
391904005802	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
391904005803	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
391904005804	active site
391904005805	metal binding site [ion binding]; metal-binding site
391904005806	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
391904005807	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
391904005808	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
391904005809	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
391904005810	Pup-ligase protein; Region: Pup_ligase; cl15463
391904005811	Pup-like protein; Region: Pup; cl05289
391904005812	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
391904005813	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
391904005814	active site
391904005815	Pup-ligase protein; Region: Pup_ligase; cl15463
391904005816	proteasome ATPase; Region: pup_AAA; TIGR03689
391904005817	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904005818	Walker A motif; other site
391904005819	ATP binding site [chemical binding]; other site
391904005820	Walker B motif; other site
391904005821	arginine finger; other site
391904005822	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
391904005823	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
391904005824	phosphoserine phosphatase SerB; Region: serB; TIGR00338
391904005825	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904005826	motif II; other site
391904005827	primosome assembly protein PriA; Provisional; Region: PRK14873
391904005828	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
391904005829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904005830	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
391904005831	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
391904005832	putative active site [active]
391904005833	substrate binding site [chemical binding]; other site
391904005834	putative cosubstrate binding site; other site
391904005835	catalytic site [active]
391904005836	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
391904005837	substrate binding site [chemical binding]; other site
391904005838	Dehydratase family; Region: ILVD_EDD; cl00340
391904005839	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
391904005840	S-adenosylmethionine synthetase; Validated; Region: PRK05250
391904005841	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
391904005842	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
391904005843	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
391904005844	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904005845	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904005846	FtsX-like permease family; Region: FtsX; pfam02687
391904005847	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904005848	FtsX-like permease family; Region: FtsX; pfam02687
391904005849	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904005850	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904005851	Walker A/P-loop; other site
391904005852	ATP binding site [chemical binding]; other site
391904005853	Q-loop/lid; other site
391904005854	ABC transporter signature motif; other site
391904005855	Walker B; other site
391904005856	D-loop; other site
391904005857	H-loop/switch region; other site
391904005858	Low molecular weight phosphatase family; Region: LMWPc; cd00115
391904005859	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
391904005860	active site
391904005861	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
391904005862	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
391904005863	folate binding site [chemical binding]; other site
391904005864	NADP+ binding site [chemical binding]; other site
391904005865	thymidylate synthase; Reviewed; Region: thyA; PRK01827
391904005866	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
391904005867	dimerization interface [polypeptide binding]; other site
391904005868	active site
391904005869	OsmC-like protein; Region: OsmC; pfam02566
391904005870	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
391904005871	Ligand Binding Site [chemical binding]; other site
391904005872	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
391904005873	Ligand Binding Site [chemical binding]; other site
391904005874	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
391904005875	NlpC/P60 family; Region: NLPC_P60; pfam00877
391904005876	NlpC/P60 family; Region: NLPC_P60; cl17555
391904005877	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
391904005878	CHAP domain; Region: CHAP; pfam05257
391904005879	phosphoserine aminotransferase; Provisional; Region: PRK03080
391904005880	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904005881	catalytic residue [active]
391904005882	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
391904005883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904005884	ATP binding site [chemical binding]; other site
391904005885	Mg2+ binding site [ion binding]; other site
391904005886	G-X-G motif; other site
391904005887	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
391904005888	PhoU domain; Region: PhoU; pfam01895
391904005889	PhoU domain; Region: PhoU; pfam01895
391904005890	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904005891	catalytic core [active]
391904005892	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
391904005893	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
391904005894	Resolvase, N terminal domain; Region: Resolvase; pfam00239
391904005895	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
391904005896	DNA-binding interface [nucleotide binding]; DNA binding site
391904005897	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
391904005898	Cytochrome P450; Region: p450; cl12078
391904005899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904005900	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
391904005901	Walker A motif; other site
391904005902	ATP binding site [chemical binding]; other site
391904005903	Walker B motif; other site
391904005904	arginine finger; other site
391904005905	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
391904005906	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
391904005907	ATP binding site [chemical binding]; other site
391904005908	substrate interface [chemical binding]; other site
391904005909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904005910	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904005911	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
391904005912	UbiA prenyltransferase family; Region: UbiA; pfam01040
391904005913	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
391904005914	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
391904005915	dimer interface [polypeptide binding]; other site
391904005916	putative anticodon binding site; other site
391904005917	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
391904005918	motif 1; other site
391904005919	dimer interface [polypeptide binding]; other site
391904005920	active site
391904005921	motif 2; other site
391904005922	motif 3; other site
391904005923	MFS transport protein AraJ; Provisional; Region: PRK10091
391904005924	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904005925	putative substrate translocation pore; other site
391904005926	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
391904005927	active site
391904005928	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
391904005929	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
391904005930	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
391904005931	putative active site [active]
391904005932	putative metal binding site [ion binding]; other site
391904005933	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
391904005934	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391904005935	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391904005936	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391904005937	binding surface
391904005938	TPR motif; other site
391904005939	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391904005940	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391904005941	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
391904005942	Protein of unknown function (DUF4125); Region: DUF4125; pfam13526
391904005943	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
391904005944	PspC domain; Region: PspC; pfam04024
391904005945	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904005946	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904005947	ATP binding site [chemical binding]; other site
391904005948	Mg2+ binding site [ion binding]; other site
391904005949	G-X-G motif; other site
391904005950	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904005951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904005952	active site
391904005953	phosphorylation site [posttranslational modification]
391904005954	intermolecular recognition site; other site
391904005955	dimerization interface [polypeptide binding]; other site
391904005956	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904005957	DNA binding residues [nucleotide binding]
391904005958	dimerization interface [polypeptide binding]; other site
391904005959	UDP-glucose 4-epimerase; Region: PLN02240
391904005960	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
391904005961	NAD binding site [chemical binding]; other site
391904005962	homodimer interface [polypeptide binding]; other site
391904005963	active site
391904005964	substrate binding site [chemical binding]; other site
391904005965	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
391904005966	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
391904005967	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
391904005968	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
391904005969	Phosphotransferase enzyme family; Region: APH; pfam01636
391904005970	active site
391904005971	substrate binding site [chemical binding]; other site
391904005972	ATP binding site [chemical binding]; other site
391904005973	1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336
391904005974	Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508
391904005975	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904005976	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005977	dimer interface [polypeptide binding]; other site
391904005978	conserved gate region; other site
391904005979	putative PBP binding loops; other site
391904005980	ABC-ATPase subunit interface; other site
391904005981	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005982	dimer interface [polypeptide binding]; other site
391904005983	conserved gate region; other site
391904005984	ABC-ATPase subunit interface; other site
391904005985	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904005986	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904005987	seryl-tRNA synthetase; Provisional; Region: PRK05431
391904005988	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
391904005989	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
391904005990	dimer interface [polypeptide binding]; other site
391904005991	active site
391904005992	motif 1; other site
391904005993	motif 2; other site
391904005994	motif 3; other site
391904005995	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
391904005996	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
391904005997	PRD domain; Region: PRD; pfam00874
391904005998	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904005999	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904006000	Winged helix-turn helix; Region: HTH_29; pfam13551
391904006001	putative transposase OrfB; Reviewed; Region: PHA02517
391904006002	HTH-like domain; Region: HTH_21; pfam13276
391904006003	Integrase core domain; Region: rve; pfam00665
391904006004	Integrase core domain; Region: rve_2; pfam13333
391904006005	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
391904006006	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
391904006007	active site turn [active]
391904006008	phosphorylation site [posttranslational modification]
391904006009	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
391904006010	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
391904006011	HPr interaction site; other site
391904006012	glycerol kinase (GK) interaction site [polypeptide binding]; other site
391904006013	active site
391904006014	phosphorylation site [posttranslational modification]
391904006015	phosphoglucomutase; Validated; Region: PRK07564
391904006016	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
391904006017	active site
391904006018	substrate binding site [chemical binding]; other site
391904006019	metal binding site [ion binding]; metal-binding site
391904006020	Transcriptional regulator; Region: Rrf2; pfam02082
391904006021	Predicted transcriptional regulator [Transcription]; Region: COG1959
391904006022	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391904006023	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
391904006024	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
391904006025	RNA/DNA hybrid binding site [nucleotide binding]; other site
391904006026	active site
391904006027	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
391904006028	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904006029	active site
391904006030	dimer interface [polypeptide binding]; other site
391904006031	DNA repair protein RadA; Provisional; Region: PRK11823
391904006032	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391904006033	Walker A motif; other site
391904006034	ATP binding site [chemical binding]; other site
391904006035	Walker B motif; other site
391904006036	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
391904006037	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
391904006038	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
391904006039	active site
391904006040	Riboflavin kinase; Region: Flavokinase; pfam01687
391904006041	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
391904006042	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
391904006043	RNA binding site [nucleotide binding]; other site
391904006044	active site
391904006045	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
391904006046	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
391904006047	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
391904006048	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
391904006049	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
391904006050	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
391904006051	G1 box; other site
391904006052	putative GEF interaction site [polypeptide binding]; other site
391904006053	GTP/Mg2+ binding site [chemical binding]; other site
391904006054	Switch I region; other site
391904006055	G2 box; other site
391904006056	G3 box; other site
391904006057	Switch II region; other site
391904006058	G4 box; other site
391904006059	G5 box; other site
391904006060	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
391904006061	Translation-initiation factor 2; Region: IF-2; pfam11987
391904006062	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
391904006063	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
391904006064	NusA N-terminal domain; Region: NusA_N; pfam08529
391904006065	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
391904006066	RNA binding site [nucleotide binding]; other site
391904006067	homodimer interface [polypeptide binding]; other site
391904006068	NusA-like KH domain; Region: KH_5; pfam13184
391904006069	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
391904006070	G-X-X-G motif; other site
391904006071	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904006072	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904006073	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006074	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006075	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006077	dimer interface [polypeptide binding]; other site
391904006078	conserved gate region; other site
391904006079	putative PBP binding loops; other site
391904006080	ABC-ATPase subunit interface; other site
391904006081	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
391904006082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006083	dimer interface [polypeptide binding]; other site
391904006084	conserved gate region; other site
391904006085	putative PBP binding loops; other site
391904006086	ABC-ATPase subunit interface; other site
391904006087	AAA domain; Region: AAA_14; pfam13173
391904006088	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904006089	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
391904006090	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
391904006091	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
391904006092	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
391904006093	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
391904006094	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
391904006095	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
391904006096	dimerization interface 3.5A [polypeptide binding]; other site
391904006097	active site
391904006098	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
391904006099	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
391904006100	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
391904006101	alphaNTD homodimer interface [polypeptide binding]; other site
391904006102	alphaNTD - beta interaction site [polypeptide binding]; other site
391904006103	alphaNTD - beta' interaction site [polypeptide binding]; other site
391904006104	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
391904006105	30S ribosomal protein S11; Validated; Region: PRK05309
391904006106	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
391904006107	30S ribosomal protein S13; Region: bact_S13; TIGR03631
391904006108	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
391904006109	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
391904006110	rRNA binding site [nucleotide binding]; other site
391904006111	predicted 30S ribosome binding site; other site
391904006112	adenylate kinase; Reviewed; Region: adk; PRK00279
391904006113	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
391904006114	AMP-binding site [chemical binding]; other site
391904006115	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
391904006116	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
391904006117	SecY translocase; Region: SecY; pfam00344
391904006118	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
391904006119	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
391904006120	23S rRNA binding site [nucleotide binding]; other site
391904006121	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
391904006122	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
391904006123	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
391904006124	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
391904006125	23S rRNA interface [nucleotide binding]; other site
391904006126	L21e interface [polypeptide binding]; other site
391904006127	5S rRNA interface [nucleotide binding]; other site
391904006128	L27 interface [polypeptide binding]; other site
391904006129	L5 interface [polypeptide binding]; other site
391904006130	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
391904006131	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
391904006132	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
391904006133	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
391904006134	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
391904006135	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
391904006136	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
391904006137	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
391904006138	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
391904006139	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
391904006140	RNA binding site [nucleotide binding]; other site
391904006141	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
391904006142	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
391904006143	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
391904006144	23S rRNA interface [nucleotide binding]; other site
391904006145	putative translocon interaction site; other site
391904006146	signal recognition particle (SRP54) interaction site; other site
391904006147	L23 interface [polypeptide binding]; other site
391904006148	trigger factor interaction site; other site
391904006149	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
391904006150	23S rRNA interface [nucleotide binding]; other site
391904006151	5S rRNA interface [nucleotide binding]; other site
391904006152	putative antibiotic binding site [chemical binding]; other site
391904006153	L25 interface [polypeptide binding]; other site
391904006154	L27 interface [polypeptide binding]; other site
391904006155	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
391904006156	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
391904006157	G-X-X-G motif; other site
391904006158	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
391904006159	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
391904006160	putative translocon binding site; other site
391904006161	protein-rRNA interface [nucleotide binding]; other site
391904006162	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
391904006163	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
391904006164	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
391904006165	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
391904006166	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
391904006167	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
391904006168	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
391904006169	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
391904006170	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
391904006171	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
391904006172	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
391904006173	putative catalytic cysteine [active]
391904006174	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
391904006175	putative active site [active]
391904006176	metal binding site [ion binding]; metal-binding site
391904006177	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
391904006178	non-specific DNA interactions [nucleotide binding]; other site
391904006179	DNA binding site [nucleotide binding]
391904006180	sequence specific DNA binding site [nucleotide binding]; other site
391904006181	putative cAMP binding site [chemical binding]; other site
391904006182	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904006183	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904006184	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
391904006185	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
391904006186	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
391904006187	active site
391904006188	catalytic site [active]
391904006189	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
391904006190	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
391904006191	23S rRNA interface [nucleotide binding]; other site
391904006192	L3 interface [polypeptide binding]; other site
391904006193	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
391904006194	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
391904006195	Uncharacterized conserved protein [Function unknown]; Region: COG1739
391904006196	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
391904006197	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
391904006198	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
391904006199	dimerization interface [polypeptide binding]; other site
391904006200	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
391904006201	NAD binding site [chemical binding]; other site
391904006202	ligand binding site [chemical binding]; other site
391904006203	catalytic site [active]
391904006204	DNA polymerase IV; Validated; Region: PRK03858
391904006205	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
391904006206	active site
391904006207	DNA binding site [nucleotide binding]
391904006208	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
391904006209	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904006210	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904006211	homodimer interface [polypeptide binding]; other site
391904006212	catalytic residue [active]
391904006213	Ferredoxin [Energy production and conversion]; Region: COG1146
391904006214	4Fe-4S binding domain; Region: Fer4; pfam00037
391904006215	amino acid transporter; Region: 2A0306; TIGR00909
391904006216	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
391904006217	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
391904006218	FAD binding domain; Region: FAD_binding_4; pfam01565
391904006219	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
391904006220	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
391904006221	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
391904006222	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
391904006223	oligomerisation interface [polypeptide binding]; other site
391904006224	mobile loop; other site
391904006225	roof hairpin; other site
391904006226	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
391904006227	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
391904006228	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
391904006229	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
391904006230	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
391904006231	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
391904006232	Part of AAA domain; Region: AAA_19; pfam13245
391904006233	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
391904006234	phosphopeptide binding site; other site
391904006235	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
391904006236	peripheral dimer interface [polypeptide binding]; other site
391904006237	core dimer interface [polypeptide binding]; other site
391904006238	L10 interface [polypeptide binding]; other site
391904006239	L11 interface [polypeptide binding]; other site
391904006240	putative EF-Tu interaction site [polypeptide binding]; other site
391904006241	putative EF-G interaction site [polypeptide binding]; other site
391904006242	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
391904006243	23S rRNA interface [nucleotide binding]; other site
391904006244	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
391904006245	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
391904006246	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
391904006247	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
391904006248	oligomer interface [polypeptide binding]; other site
391904006249	RNA binding site [nucleotide binding]; other site
391904006250	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
391904006251	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
391904006252	RNase E interface [polypeptide binding]; other site
391904006253	trimer interface [polypeptide binding]; other site
391904006254	active site
391904006255	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
391904006256	putative nucleic acid binding region [nucleotide binding]; other site
391904006257	G-X-X-G motif; other site
391904006258	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
391904006259	RNA binding site [nucleotide binding]; other site
391904006260	domain interface; other site
391904006261	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
391904006262	16S/18S rRNA binding site [nucleotide binding]; other site
391904006263	S13e-L30e interaction site [polypeptide binding]; other site
391904006264	25S rRNA binding site [nucleotide binding]; other site
391904006265	ABC transporter; Region: ABC_tran; pfam00005
391904006266	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904006267	Q-loop/lid; other site
391904006268	Walker B; other site
391904006269	D-loop; other site
391904006270	H-loop/switch region; other site
391904006271	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
391904006272	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391904006273	Walker A/P-loop; other site
391904006274	ATP binding site [chemical binding]; other site
391904006275	Q-loop/lid; other site
391904006276	ABC transporter signature motif; other site
391904006277	Walker B; other site
391904006278	D-loop; other site
391904006279	H-loop/switch region; other site
391904006280	type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893
391904006281	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904006282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904006283	active site
391904006284	phosphorylation site [posttranslational modification]
391904006285	intermolecular recognition site; other site
391904006286	dimerization interface [polypeptide binding]; other site
391904006287	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904006288	DNA binding residues [nucleotide binding]
391904006289	dimerization interface [polypeptide binding]; other site
391904006290	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904006291	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904006292	Integrase core domain; Region: rve; pfam00665
391904006293	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
391904006294	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
391904006295	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
391904006296	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
391904006297	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
391904006298	phosphate binding site [ion binding]; other site
391904006299	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
391904006300	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
391904006301	putative active site [active]
391904006302	putative catalytic site [active]
391904006303	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
391904006304	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
391904006305	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
391904006306	putative NAD(P) binding site [chemical binding]; other site
391904006307	active site
391904006308	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
391904006309	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
391904006310	active site
391904006311	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
391904006312	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
391904006313	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
391904006314	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
391904006315	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
391904006316	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391904006317	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
391904006318	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
391904006319	carboxyltransferase (CT) interaction site; other site
391904006320	biotinylation site [posttranslational modification]; other site
391904006321	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
391904006322	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
391904006323	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
391904006324	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
391904006325	Transcriptional regulator [Transcription]; Region: IclR; COG1414
391904006326	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
391904006327	Bacterial transcriptional regulator; Region: IclR; pfam01614
391904006328	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
391904006329	Transcriptional regulator [Transcription]; Region: IclR; COG1414
391904006330	Bacterial transcriptional regulator; Region: IclR; pfam01614
391904006331	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
391904006332	mRNA/rRNA interface [nucleotide binding]; other site
391904006333	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
391904006334	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
391904006335	23S rRNA interface [nucleotide binding]; other site
391904006336	L7/L12 interface [polypeptide binding]; other site
391904006337	putative thiostrepton binding site; other site
391904006338	L25 interface [polypeptide binding]; other site
391904006339	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
391904006340	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
391904006341	putative homodimer interface [polypeptide binding]; other site
391904006342	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
391904006343	heterodimer interface [polypeptide binding]; other site
391904006344	homodimer interface [polypeptide binding]; other site
391904006345	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
391904006346	aspartate aminotransferase; Provisional; Region: PRK05764
391904006347	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904006348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904006349	homodimer interface [polypeptide binding]; other site
391904006350	catalytic residue [active]
391904006351	gamma-glutamyl kinase; Provisional; Region: PRK05429
391904006352	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
391904006353	nucleotide binding site [chemical binding]; other site
391904006354	homotetrameric interface [polypeptide binding]; other site
391904006355	putative phosphate binding site [ion binding]; other site
391904006356	putative allosteric binding site; other site
391904006357	PUA domain; Region: PUA; pfam01472
391904006358	GTPase CgtA; Reviewed; Region: obgE; PRK12296
391904006359	GTP1/OBG; Region: GTP1_OBG; pfam01018
391904006360	Obg GTPase; Region: Obg; cd01898
391904006361	G1 box; other site
391904006362	GTP/Mg2+ binding site [chemical binding]; other site
391904006363	Switch I region; other site
391904006364	G2 box; other site
391904006365	G3 box; other site
391904006366	Switch II region; other site
391904006367	G4 box; other site
391904006368	G5 box; other site
391904006369	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
391904006370	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
391904006371	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
391904006372	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
391904006373	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
391904006374	homodimer interface [polypeptide binding]; other site
391904006375	oligonucleotide binding site [chemical binding]; other site
391904006376	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
391904006377	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
391904006378	metal binding site [ion binding]; metal-binding site
391904006379	putative dimer interface [polypeptide binding]; other site
391904006380	Predicted permeases [General function prediction only]; Region: COG0679
391904006381	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
391904006382	Amidohydrolase; Region: Amidohydro_2; pfam04909
391904006383	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
391904006384	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
391904006385	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904006386	putative substrate translocation pore; other site
391904006387	short chain dehydrogenase; Provisional; Region: PRK08628
391904006388	classical (c) SDRs; Region: SDR_c; cd05233
391904006389	NAD(P) binding site [chemical binding]; other site
391904006390	active site
391904006391	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
391904006392	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
391904006393	metal binding site [ion binding]; metal-binding site
391904006394	substrate binding pocket [chemical binding]; other site
391904006395	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904006396	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904006397	DNA binding site [nucleotide binding]
391904006398	domain linker motif; other site
391904006399	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904006400	dimerization interface [polypeptide binding]; other site
391904006401	ligand binding site [chemical binding]; other site
391904006402	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
391904006403	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904006404	Walker A/P-loop; other site
391904006405	ATP binding site [chemical binding]; other site
391904006406	Q-loop/lid; other site
391904006407	ABC transporter signature motif; other site
391904006408	Walker B; other site
391904006409	D-loop; other site
391904006410	H-loop/switch region; other site
391904006411	Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA; cl00012
391904006412	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
391904006413	putative active site [active]
391904006414	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
391904006415	dimer interface [polypeptide binding]; other site
391904006416	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
391904006417	nudix motif; other site
391904006418	homoserine kinase; Provisional; Region: PRK01212
391904006419	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
391904006420	homoserine dehydrogenase; Provisional; Region: PRK06349
391904006421	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
391904006422	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
391904006423	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
391904006424	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
391904006425	catalytic residue [active]
391904006426	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
391904006427	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
391904006428	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
391904006429	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
391904006430	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391904006431	active site
391904006432	HIGH motif; other site
391904006433	nucleotide binding site [chemical binding]; other site
391904006434	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
391904006435	KMSK motif region; other site
391904006436	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
391904006437	tRNA binding surface [nucleotide binding]; other site
391904006438	anticodon binding site; other site
391904006439	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391904006440	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391904006441	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
391904006442	putative dimerization interface [polypeptide binding]; other site
391904006443	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
391904006444	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904006445	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904006446	homodimer interface [polypeptide binding]; other site
391904006447	catalytic residue [active]
391904006448	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
391904006449	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
391904006450	hinge; other site
391904006451	active site
391904006452	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
391904006453	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391904006454	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
391904006455	Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810
391904006456	active site
391904006457	FMN binding site [chemical binding]; other site
391904006458	substrate binding site [chemical binding]; other site
391904006459	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
391904006460	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
391904006461	substrate binding site [chemical binding]; other site
391904006462	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
391904006463	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
391904006464	substrate binding site [chemical binding]; other site
391904006465	ligand binding site [chemical binding]; other site
391904006466	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
391904006467	Transcriptional regulator [Transcription]; Region: IclR; COG1414
391904006468	Bacterial transcriptional regulator; Region: IclR; pfam01614
391904006469	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
391904006470	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
391904006471	putative active site [active]
391904006472	putative metal binding site [ion binding]; other site
391904006473	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
391904006474	polyphosphate kinase; Provisional; Region: PRK05443
391904006475	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
391904006476	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
391904006477	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
391904006478	putative domain interface [polypeptide binding]; other site
391904006479	putative active site [active]
391904006480	catalytic site [active]
391904006481	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
391904006482	putative domain interface [polypeptide binding]; other site
391904006483	putative active site [active]
391904006484	catalytic site [active]
391904006485	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
391904006486	active site
391904006487	Ap6A binding site [chemical binding]; other site
391904006488	nudix motif; other site
391904006489	metal binding site [ion binding]; metal-binding site
391904006490	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904006491	catalytic core [active]
391904006492	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
391904006493	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
391904006494	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
391904006495	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
391904006496	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904006497	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904006498	Winged helix-turn helix; Region: HTH_29; pfam13551
391904006499	putative transposase OrfB; Reviewed; Region: PHA02517
391904006500	HTH-like domain; Region: HTH_21; pfam13276
391904006501	Integrase core domain; Region: rve; pfam00665
391904006502	Integrase core domain; Region: rve_2; pfam13333
391904006503	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
391904006504	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
391904006505	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
391904006506	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
391904006507	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
391904006508	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
391904006509	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
391904006510	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
391904006511	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
391904006512	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
391904006513	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
391904006514	inhibitor site; inhibition site
391904006515	active site
391904006516	dimer interface [polypeptide binding]; other site
391904006517	catalytic residue [active]
391904006518	short chain dehydrogenase; Provisional; Region: PRK08628
391904006519	classical (c) SDRs; Region: SDR_c; cd05233
391904006520	NAD(P) binding site [chemical binding]; other site
391904006521	active site
391904006522	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
391904006523	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
391904006524	metal binding site [ion binding]; metal-binding site
391904006525	substrate binding pocket [chemical binding]; other site
391904006526	Protein of unknown function, DUF624; Region: DUF624; cl02369
391904006527	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006528	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006529	dimer interface [polypeptide binding]; other site
391904006530	conserved gate region; other site
391904006531	ABC-ATPase subunit interface; other site
391904006532	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
391904006533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006534	dimer interface [polypeptide binding]; other site
391904006535	conserved gate region; other site
391904006536	ABC-ATPase subunit interface; other site
391904006537	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006538	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
391904006539	catalytic site [active]
391904006540	BNR repeat-like domain; Region: BNR_2; pfam13088
391904006541	Asp-box motif; other site
391904006542	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
391904006543	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
391904006544	inhibitor site; inhibition site
391904006545	active site
391904006546	dimer interface [polypeptide binding]; other site
391904006547	catalytic residue [active]
391904006548	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006549	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006550	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006551	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006552	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
391904006553	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
391904006554	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
391904006555	putative active site [active]
391904006556	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
391904006557	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006558	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
391904006559	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
391904006560	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
391904006561	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
391904006562	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006564	dimer interface [polypeptide binding]; other site
391904006565	conserved gate region; other site
391904006566	putative PBP binding loops; other site
391904006567	ABC-ATPase subunit interface; other site
391904006568	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006569	dimer interface [polypeptide binding]; other site
391904006570	conserved gate region; other site
391904006571	putative PBP binding loops; other site
391904006572	ABC-ATPase subunit interface; other site
391904006573	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
391904006574	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904006575	Walker A/P-loop; other site
391904006576	ATP binding site [chemical binding]; other site
391904006577	Q-loop/lid; other site
391904006578	ABC transporter signature motif; other site
391904006579	Walker B; other site
391904006580	D-loop; other site
391904006581	H-loop/switch region; other site
391904006582	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
391904006583	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904006584	active site
391904006585	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
391904006586	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
391904006587	active site
391904006588	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006589	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
391904006590	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006591	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006592	dimer interface [polypeptide binding]; other site
391904006593	conserved gate region; other site
391904006594	putative PBP binding loops; other site
391904006595	ABC-ATPase subunit interface; other site
391904006596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006597	dimer interface [polypeptide binding]; other site
391904006598	conserved gate region; other site
391904006599	putative PBP binding loops; other site
391904006600	ABC-ATPase subunit interface; other site
391904006601	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
391904006602	active site
391904006603	catalytic site [active]
391904006604	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
391904006605	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
391904006606	active site
391904006607	HIGH motif; other site
391904006608	nucleotide binding site [chemical binding]; other site
391904006609	active site
391904006610	KMSKS motif; other site
391904006611	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
391904006612	Clp amino terminal domain; Region: Clp_N; pfam02861
391904006613	Clp amino terminal domain; Region: Clp_N; pfam02861
391904006614	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904006615	Walker A motif; other site
391904006616	ATP binding site [chemical binding]; other site
391904006617	Walker B motif; other site
391904006618	arginine finger; other site
391904006619	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904006620	Walker A motif; other site
391904006621	ATP binding site [chemical binding]; other site
391904006622	Walker B motif; other site
391904006623	arginine finger; other site
391904006624	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
391904006625	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
391904006626	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904006627	Coenzyme A binding pocket [chemical binding]; other site
391904006628	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
391904006629	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
391904006630	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
391904006631	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
391904006632	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391904006633	UDP-galactopyranose mutase; Region: GLF; pfam03275
391904006634	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006636	dimer interface [polypeptide binding]; other site
391904006637	conserved gate region; other site
391904006638	putative PBP binding loops; other site
391904006639	ABC-ATPase subunit interface; other site
391904006640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006641	dimer interface [polypeptide binding]; other site
391904006642	conserved gate region; other site
391904006643	putative PBP binding loops; other site
391904006644	ABC-ATPase subunit interface; other site
391904006645	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006646	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006647	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
391904006648	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
391904006649	Ligand binding site; other site
391904006650	Putative Catalytic site; other site
391904006651	DXD motif; other site
391904006652	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
391904006653	Acyltransferase family; Region: Acyl_transf_3; pfam01757
391904006654	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391904006655	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391904006656	active site
391904006657	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
391904006658	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
391904006659	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
391904006660	Ligand binding site; other site
391904006661	metal-binding site
391904006662	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
391904006663	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
391904006664	Walker A/P-loop; other site
391904006665	ATP binding site [chemical binding]; other site
391904006666	Q-loop/lid; other site
391904006667	ABC transporter signature motif; other site
391904006668	Walker B; other site
391904006669	D-loop; other site
391904006670	H-loop/switch region; other site
391904006671	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
391904006672	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
391904006673	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
391904006674	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
391904006675	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
391904006676	Ligand binding site; other site
391904006677	metal-binding site
391904006678	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
391904006679	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
391904006680	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
391904006681	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
391904006682	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
391904006683	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
391904006684	NAD binding site [chemical binding]; other site
391904006685	substrate binding site [chemical binding]; other site
391904006686	homodimer interface [polypeptide binding]; other site
391904006687	active site
391904006688	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
391904006689	Acyltransferase family; Region: Acyl_transf_3; pfam01757
391904006690	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
391904006691	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904006692	FtsX-like permease family; Region: FtsX; pfam02687
391904006693	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904006694	Walker A/P-loop; other site
391904006695	ATP binding site [chemical binding]; other site
391904006696	ABC transporter; Region: ABC_tran; pfam00005
391904006697	Q-loop/lid; other site
391904006698	ABC transporter signature motif; other site
391904006699	Walker B; other site
391904006700	D-loop; other site
391904006701	H-loop/switch region; other site
391904006702	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
391904006703	Zn2+ binding site [ion binding]; other site
391904006704	Mg2+ binding site [ion binding]; other site
391904006705	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
391904006706	putative active site [active]
391904006707	putative dimer interface [polypeptide binding]; other site
391904006708	K+ potassium transporter; Region: K_trans; pfam02705
391904006709	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
391904006710	active site
391904006711	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
391904006712	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
391904006713	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
391904006714	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904006715	putative substrate translocation pore; other site
391904006716	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904006717	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904006718	nucleotide binding site [chemical binding]; other site
391904006719	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
391904006720	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
391904006721	putative active site cavity [active]
391904006722	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
391904006723	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
391904006724	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
391904006725	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
391904006726	Fic family protein [Function unknown]; Region: COG3177
391904006727	Fic/DOC family; Region: Fic; pfam02661
391904006728	Fic family protein [Function unknown]; Region: COG3177
391904006729	Fic/DOC family; Region: Fic; pfam02661
391904006730	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904006731	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904006732	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
391904006733	Walker A/P-loop; other site
391904006734	ATP binding site [chemical binding]; other site
391904006735	Q-loop/lid; other site
391904006736	ABC transporter signature motif; other site
391904006737	Walker B; other site
391904006738	D-loop; other site
391904006739	H-loop/switch region; other site
391904006740	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904006741	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904006742	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904006743	Walker A/P-loop; other site
391904006744	ATP binding site [chemical binding]; other site
391904006745	Q-loop/lid; other site
391904006746	ABC transporter signature motif; other site
391904006747	Walker B; other site
391904006748	D-loop; other site
391904006749	H-loop/switch region; other site
391904006750	Archaeal ATPase; Region: Arch_ATPase; pfam01637
391904006751	AAA ATPase domain; Region: AAA_16; pfam13191
391904006752	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
391904006753	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904006754	AAA domain; Region: AAA_14; pfam13173
391904006755	Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004
391904006756	putative substrate binding site [chemical binding]; other site
391904006757	active site
391904006758	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006760	dimer interface [polypeptide binding]; other site
391904006761	conserved gate region; other site
391904006762	putative PBP binding loops; other site
391904006763	ABC-ATPase subunit interface; other site
391904006764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006765	dimer interface [polypeptide binding]; other site
391904006766	conserved gate region; other site
391904006767	putative PBP binding loops; other site
391904006768	ABC-ATPase subunit interface; other site
391904006769	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006770	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006771	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904006772	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904006773	DNA binding site [nucleotide binding]
391904006774	domain linker motif; other site
391904006775	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904006776	ligand binding site [chemical binding]; other site
391904006777	dimerization interface [polypeptide binding]; other site
391904006778	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
391904006779	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
391904006780	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
391904006781	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
391904006782	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904006783	Walker A motif; other site
391904006784	ATP binding site [chemical binding]; other site
391904006785	Walker B motif; other site
391904006786	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904006787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904006788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904006789	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
391904006790	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
391904006791	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
391904006792	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904006793	Walker A/P-loop; other site
391904006794	ATP binding site [chemical binding]; other site
391904006795	Q-loop/lid; other site
391904006796	ABC transporter signature motif; other site
391904006797	Walker B; other site
391904006798	D-loop; other site
391904006799	H-loop/switch region; other site
391904006800	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
391904006801	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904006802	Walker A/P-loop; other site
391904006803	ATP binding site [chemical binding]; other site
391904006804	Q-loop/lid; other site
391904006805	ABC transporter signature motif; other site
391904006806	Walker B; other site
391904006807	D-loop; other site
391904006808	H-loop/switch region; other site
391904006809	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
391904006810	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904006811	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006812	dimer interface [polypeptide binding]; other site
391904006813	conserved gate region; other site
391904006814	putative PBP binding loops; other site
391904006815	ABC-ATPase subunit interface; other site
391904006816	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904006817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006818	dimer interface [polypeptide binding]; other site
391904006819	conserved gate region; other site
391904006820	putative PBP binding loops; other site
391904006821	ABC-ATPase subunit interface; other site
391904006822	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
391904006823	trimer interface [polypeptide binding]; other site
391904006824	active site
391904006825	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
391904006826	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
391904006827	active site
391904006828	HIGH motif; other site
391904006829	KMSKS motif; other site
391904006830	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
391904006831	tRNA binding surface [nucleotide binding]; other site
391904006832	anticodon binding site; other site
391904006833	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
391904006834	Predicted methyltransferases [General function prediction only]; Region: COG0313
391904006835	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
391904006836	putative SAM binding site [chemical binding]; other site
391904006837	putative homodimer interface [polypeptide binding]; other site
391904006838	MULE transposase domain; Region: MULE; pfam10551
391904006839	ApbE family; Region: ApbE; pfam02424
391904006840	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904006841	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904006842	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
391904006843	Walker A/P-loop; other site
391904006844	ATP binding site [chemical binding]; other site
391904006845	Q-loop/lid; other site
391904006846	ABC transporter signature motif; other site
391904006847	Walker B; other site
391904006848	D-loop; other site
391904006849	H-loop/switch region; other site
391904006850	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904006851	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904006852	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904006853	Walker A/P-loop; other site
391904006854	ATP binding site [chemical binding]; other site
391904006855	Q-loop/lid; other site
391904006856	ABC transporter signature motif; other site
391904006857	Walker B; other site
391904006858	D-loop; other site
391904006859	H-loop/switch region; other site
391904006860	MarR family; Region: MarR_2; cl17246
391904006861	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
391904006862	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
391904006863	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
391904006864	Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795
391904006865	FtsX-like permease family; Region: FtsX; pfam02687
391904006866	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904006867	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904006868	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904006869	Walker A/P-loop; other site
391904006870	ATP binding site [chemical binding]; other site
391904006871	Q-loop/lid; other site
391904006872	ABC transporter signature motif; other site
391904006873	Walker B; other site
391904006874	D-loop; other site
391904006875	H-loop/switch region; other site
391904006876	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
391904006877	Protein of unknown function, DUF624; Region: DUF624; pfam04854
391904006878	Protein of unknown function, DUF624; Region: DUF624; cl02369
391904006879	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006880	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006881	dimer interface [polypeptide binding]; other site
391904006882	conserved gate region; other site
391904006883	putative PBP binding loops; other site
391904006884	ABC-ATPase subunit interface; other site
391904006885	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
391904006886	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006887	putative PBP binding loops; other site
391904006888	dimer interface [polypeptide binding]; other site
391904006889	ABC-ATPase subunit interface; other site
391904006890	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904006891	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904006892	DNA binding site [nucleotide binding]
391904006893	domain linker motif; other site
391904006894	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904006895	ligand binding site [chemical binding]; other site
391904006896	dimerization interface [polypeptide binding]; other site
391904006897	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006898	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
391904006899	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904006900	catalytic core [active]
391904006901	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
391904006902	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
391904006903	dimer interface [polypeptide binding]; other site
391904006904	FMN binding site [chemical binding]; other site
391904006905	NADPH bind site [chemical binding]; other site
391904006906	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
391904006907	Predicted membrane protein [Function unknown]; Region: COG1511
391904006908	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
391904006909	Predicted membrane protein [Function unknown]; Region: COG1511
391904006910	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
391904006911	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
391904006912	NAD-dependent deacetylase; Provisional; Region: PRK00481
391904006913	SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent...; Region: SIRT7; cd01410
391904006914	NAD+ binding site [chemical binding]; other site
391904006915	substrate binding site [chemical binding]; other site
391904006916	Zn binding site [ion binding]; other site
391904006917	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
391904006918	tetramer interface [polypeptide binding]; other site
391904006919	threonine dehydratase; Provisional; Region: PRK08198
391904006920	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904006921	catalytic residue [active]
391904006922	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
391904006923	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
391904006924	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
391904006925	Ca binding site [ion binding]; other site
391904006926	active site
391904006927	catalytic site [active]
391904006928	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
391904006929	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006930	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006931	dimer interface [polypeptide binding]; other site
391904006932	conserved gate region; other site
391904006933	putative PBP binding loops; other site
391904006934	ABC-ATPase subunit interface; other site
391904006935	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
391904006936	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006937	dimer interface [polypeptide binding]; other site
391904006938	conserved gate region; other site
391904006939	putative PBP binding loops; other site
391904006940	ABC-ATPase subunit interface; other site
391904006941	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006942	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
391904006943	Transcriptional regulators [Transcription]; Region: MarR; COG1846
391904006944	MarR family; Region: MarR_2; pfam12802
391904006945	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904006946	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904006947	nucleotide binding site [chemical binding]; other site
391904006948	Melibiase; Region: Melibiase; pfam02065
391904006949	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
391904006950	nucleoside/Zn binding site; other site
391904006951	dimer interface [polypeptide binding]; other site
391904006952	catalytic motif [active]
391904006953	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
391904006954	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
391904006955	Serine hydrolase (FSH1); Region: FSH1; pfam03959
391904006956	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
391904006957	trimer interface [polypeptide binding]; other site
391904006958	active site
391904006959	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
391904006960	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
391904006961	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
391904006962	active site
391904006963	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
391904006964	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
391904006965	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
391904006966	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
391904006967	Soluble P-type ATPase [General function prediction only]; Region: COG4087
391904006968	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
391904006969	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904006970	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904006971	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
391904006972	HPr interaction site; other site
391904006973	glycerol kinase (GK) interaction site [polypeptide binding]; other site
391904006974	active site
391904006975	phosphorylation site [posttranslational modification]
391904006976	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
391904006977	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
391904006978	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
391904006979	active site turn [active]
391904006980	phosphorylation site [posttranslational modification]
391904006981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904006982	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904006983	putative substrate translocation pore; other site
391904006984	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
391904006985	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
391904006986	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
391904006987	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
391904006988	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
391904006989	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
391904006990	Walker A/P-loop; other site
391904006991	ATP binding site [chemical binding]; other site
391904006992	Q-loop/lid; other site
391904006993	ABC transporter signature motif; other site
391904006994	Walker B; other site
391904006995	D-loop; other site
391904006996	H-loop/switch region; other site
391904006997	TOBE domain; Region: TOBE_2; pfam08402
391904006998	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391904006999	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
391904007000	active site
391904007001	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
391904007002	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
391904007003	dimer interface [polypeptide binding]; other site
391904007004	putative radical transfer pathway; other site
391904007005	diiron center [ion binding]; other site
391904007006	tyrosyl radical; other site
391904007007	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
391904007008	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
391904007009	Class I ribonucleotide reductase; Region: RNR_I; cd01679
391904007010	active site
391904007011	dimer interface [polypeptide binding]; other site
391904007012	catalytic residues [active]
391904007013	effector binding site; other site
391904007014	R2 peptide binding site; other site
391904007015	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
391904007016	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
391904007017	catalytic residues [active]
391904007018	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
391904007019	Catalytic domain of Protein Kinases; Region: PKc; cd00180
391904007020	active site
391904007021	ATP binding site [chemical binding]; other site
391904007022	substrate binding site [chemical binding]; other site
391904007023	activation loop (A-loop); other site
391904007024	Gamma interferon inducible lysosomal thiol reductase (GILT); Region: GILT; pfam03227
391904007025	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
391904007026	Domain of unknown function (DUF348); Region: DUF348; pfam03990
391904007027	G5 domain; Region: G5; pfam07501
391904007028	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
391904007029	N-acetyl-D-glucosamine binding site [chemical binding]; other site
391904007030	catalytic residue [active]
391904007031	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
391904007032	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
391904007033	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
391904007034	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
391904007035	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
391904007036	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
391904007037	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
391904007038	active site
391904007039	NTP binding site [chemical binding]; other site
391904007040	metal binding triad [ion binding]; metal-binding site
391904007041	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
391904007042	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
391904007043	Zn2+ binding site [ion binding]; other site
391904007044	Mg2+ binding site [ion binding]; other site
391904007045	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
391904007046	active site
391904007047	Ap6A binding site [chemical binding]; other site
391904007048	nudix motif; other site
391904007049	metal binding site [ion binding]; metal-binding site
391904007050	integral membrane protein MviN; Region: mviN; TIGR01695
391904007051	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
391904007052	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
391904007053	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
391904007054	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391904007055	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
391904007056	ParB-like nuclease domain; Region: ParB; smart00470
391904007057	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
391904007058	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
391904007059	P-loop; other site
391904007060	Magnesium ion binding site [ion binding]; other site
391904007061	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
391904007062	Magnesium ion binding site [ion binding]; other site
391904007063	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
391904007064	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
391904007065	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
391904007066	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
391904007067	G-X-X-G motif; other site
391904007068	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
391904007069	RxxxH motif; other site
391904007070	putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315
391904007071	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
391904007072	Ribonuclease P; Region: Ribonuclease_P; pfam00825
391904007073	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399