-- dump date   	20140619_002833
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
391904000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
391904000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904000003	Walker A motif; other site
391904000004	ATP binding site [chemical binding]; other site
391904000005	Walker B motif; other site
391904000006	arginine finger; other site
391904000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
391904000008	DnaA box-binding interface [nucleotide binding]; other site
391904000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
391904000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
391904000011	putative DNA binding surface [nucleotide binding]; other site
391904000012	dimer interface [polypeptide binding]; other site
391904000013	beta-clamp/clamp loader binding surface; other site
391904000014	beta-clamp/translesion DNA polymerase binding surface; other site
391904000015	recombination protein F; Reviewed; Region: recF; PRK00064
391904000016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904000017	Walker A/P-loop; other site
391904000018	ATP binding site [chemical binding]; other site
391904000019	Q-loop/lid; other site
391904000020	ABC transporter signature motif; other site
391904000021	Walker B; other site
391904000022	D-loop; other site
391904000023	H-loop/switch region; other site
391904000024	Protein of unknown function (DUF721); Region: DUF721; pfam05258
391904000025	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
391904000026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904000027	ATP binding site [chemical binding]; other site
391904000028	Mg2+ binding site [ion binding]; other site
391904000029	G-X-G motif; other site
391904000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
391904000031	anchoring element; other site
391904000032	dimer interface [polypeptide binding]; other site
391904000033	ATP binding site [chemical binding]; other site
391904000034	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
391904000035	active site
391904000036	metal binding site [ion binding]; metal-binding site
391904000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
391904000038	DNA gyrase subunit A; Validated; Region: PRK05560
391904000039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
391904000040	CAP-like domain; other site
391904000041	active site
391904000042	primary dimer interface [polypeptide binding]; other site
391904000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904000049	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
391904000050	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
391904000051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
391904000052	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
391904000053	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904000054	glutamate dehydrogenase; Provisional; Region: PRK09414
391904000055	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
391904000056	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
391904000057	NAD(P) binding site [chemical binding]; other site
391904000058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
391904000059	RelB antitoxin; Region: RelB; cl01171
391904000060	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
391904000061	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
391904000062	active site
391904000063	metal binding site [ion binding]; metal-binding site
391904000064	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
391904000065	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000066	dimer interface [polypeptide binding]; other site
391904000067	conserved gate region; other site
391904000068	putative PBP binding loops; other site
391904000069	ABC-ATPase subunit interface; other site
391904000070	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
391904000071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000072	dimer interface [polypeptide binding]; other site
391904000073	conserved gate region; other site
391904000074	ABC-ATPase subunit interface; other site
391904000075	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
391904000076	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
391904000077	Walker A/P-loop; other site
391904000078	ATP binding site [chemical binding]; other site
391904000079	Q-loop/lid; other site
391904000080	ABC transporter signature motif; other site
391904000081	Walker B; other site
391904000082	D-loop; other site
391904000083	H-loop/switch region; other site
391904000084	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
391904000085	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
391904000086	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
391904000087	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
391904000088	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
391904000089	putative active site [active]
391904000090	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
391904000091	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
391904000092	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904000093	AAA domain; Region: AAA_14; pfam13173
391904000094	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904000095	Protein of unknown function DUF45; Region: DUF45; pfam01863
391904000096	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904000097	AAA domain; Region: AAA_14; pfam13173
391904000098	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904000099	Ferritin-like domain; Region: Ferritin; pfam00210
391904000100	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
391904000101	dimerization interface [polypeptide binding]; other site
391904000102	DPS ferroxidase diiron center [ion binding]; other site
391904000103	ion pore; other site
391904000104	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
391904000105	Domain of unknown function DUF21; Region: DUF21; pfam01595
391904000106	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
391904000107	Transporter associated domain; Region: CorC_HlyC; smart01091
391904000108	AAA ATPase domain; Region: AAA_16; pfam13191
391904000109	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
391904000110	active site clefts [active]
391904000111	zinc binding site [ion binding]; other site
391904000112	dimer interface [polypeptide binding]; other site
391904000113	peroxiredoxin; Region: AhpC; TIGR03137
391904000114	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
391904000115	dimer interface [polypeptide binding]; other site
391904000116	decamer (pentamer of dimers) interface [polypeptide binding]; other site
391904000117	catalytic triad [active]
391904000118	peroxidatic and resolving cysteines [active]
391904000119	putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143
391904000120	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391904000121	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391904000122	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
391904000123	catalytic residue [active]
391904000124	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
391904000125	catalytic residues [active]
391904000126	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
391904000127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000128	putative substrate translocation pore; other site
391904000129	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904000130	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904000131	Transposase; Region: HTH_Tnp_1; cl17663
391904000132	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904000133	putative transposase OrfB; Reviewed; Region: PHA02517
391904000134	HTH-like domain; Region: HTH_21; pfam13276
391904000135	Integrase core domain; Region: rve; pfam00665
391904000136	Integrase core domain; Region: rve_2; pfam13333
391904000137	Transposase, Mutator family; Region: Transposase_mut; cl19537
391904000138	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
391904000139	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
391904000140	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904000141	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904000142	DNA binding site [nucleotide binding]
391904000143	domain linker motif; other site
391904000144	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904000145	ligand binding site [chemical binding]; other site
391904000146	dimerization interface [polypeptide binding]; other site
391904000147	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904000148	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904000149	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904000150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000151	dimer interface [polypeptide binding]; other site
391904000152	conserved gate region; other site
391904000153	putative PBP binding loops; other site
391904000154	ABC-ATPase subunit interface; other site
391904000155	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904000156	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000157	dimer interface [polypeptide binding]; other site
391904000158	conserved gate region; other site
391904000159	putative PBP binding loops; other site
391904000160	ABC-ATPase subunit interface; other site
391904000161	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
391904000162	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
391904000163	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
391904000164	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
391904000165	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904000166	AAA domain; Region: AAA_14; pfam13173
391904000167	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904000168	AAA domain; Region: AAA_14; pfam13173
391904000169	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904000170	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
391904000171	Divergent AAA domain; Region: AAA_4; pfam04326
391904000172	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
391904000173	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
391904000174	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
391904000175	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904000176	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000177	dimer interface [polypeptide binding]; other site
391904000178	conserved gate region; other site
391904000179	putative PBP binding loops; other site
391904000180	ABC-ATPase subunit interface; other site
391904000181	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904000182	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000183	dimer interface [polypeptide binding]; other site
391904000184	conserved gate region; other site
391904000185	putative PBP binding loops; other site
391904000186	ABC-ATPase subunit interface; other site
391904000187	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
391904000188	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904000189	Walker A/P-loop; other site
391904000190	ATP binding site [chemical binding]; other site
391904000191	Q-loop/lid; other site
391904000192	ABC transporter signature motif; other site
391904000193	Walker B; other site
391904000194	D-loop; other site
391904000195	H-loop/switch region; other site
391904000196	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904000197	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904000198	Walker A/P-loop; other site
391904000199	ATP binding site [chemical binding]; other site
391904000200	Q-loop/lid; other site
391904000201	ABC transporter signature motif; other site
391904000202	Walker B; other site
391904000203	D-loop; other site
391904000204	H-loop/switch region; other site
391904000205	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904000206	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
391904000207	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
391904000208	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
391904000209	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
391904000210	Na binding site [ion binding]; other site
391904000211	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
391904000212	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
391904000213	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
391904000214	active site
391904000215	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
391904000216	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
391904000217	active site
391904000218	HIGH motif; other site
391904000219	dimer interface [polypeptide binding]; other site
391904000220	KMSKS motif; other site
391904000221	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
391904000222	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904000223	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904000224	active site
391904000225	phosphorylation site [posttranslational modification]
391904000226	intermolecular recognition site; other site
391904000227	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904000228	DNA binding residues [nucleotide binding]
391904000229	dimerization interface [polypeptide binding]; other site
391904000230	PRA1 family protein; Region: PRA1; cl02137
391904000231	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904000232	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000233	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
391904000234	homodimer interface [polypeptide binding]; other site
391904000235	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
391904000236	active site pocket [active]
391904000237	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
391904000238	putative septation inhibitor protein; Reviewed; Region: PRK02251
391904000239	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
391904000240	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
391904000241	active site
391904000242	catalytic site [active]
391904000243	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
391904000244	Glutamine amidotransferase class-I; Region: GATase; pfam00117
391904000245	glutamine binding [chemical binding]; other site
391904000246	catalytic triad [active]
391904000247	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
391904000248	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
391904000249	active site
391904000250	ATP binding site [chemical binding]; other site
391904000251	substrate binding site [chemical binding]; other site
391904000252	activation loop (A-loop); other site
391904000253	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
391904000254	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
391904000255	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
391904000256	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
391904000257	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
391904000258	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
391904000259	active site
391904000260	ATP binding site [chemical binding]; other site
391904000261	substrate binding site [chemical binding]; other site
391904000262	activation loop (A-loop); other site
391904000263	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
391904000264	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
391904000265	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
391904000266	active site
391904000267	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
391904000268	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
391904000269	phosphopeptide binding site; other site
391904000270	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
391904000271	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
391904000272	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
391904000273	phosphopeptide binding site; other site
391904000274	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
391904000275	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
391904000276	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391904000277	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
391904000278	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391904000279	aromatic amino acid exporter; Provisional; Region: PRK11689
391904000280	EamA-like transporter family; Region: EamA; pfam00892
391904000281	Putative esterase; Region: Esterase; pfam00756
391904000282	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
391904000283	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
391904000284	methionine sulfoxide reductase B; Provisional; Region: PRK00222
391904000285	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869
391904000286	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
391904000287	cofactor binding site; other site
391904000288	DNA binding site [nucleotide binding]
391904000289	substrate interaction site [chemical binding]; other site
391904000290	hypothetical protein; Provisional; Region: PRK01119
391904000291	Haemolysin-III related; Region: HlyIII; pfam03006
391904000292	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
391904000293	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
391904000294	putative dimer interface [polypeptide binding]; other site
391904000295	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
391904000296	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
391904000297	conserved cys residue [active]
391904000298	PemK-like protein; Region: PemK; cl00995
391904000299	Queuine tRNA-ribosyltransferase; Region: TGT; cl19224
391904000300	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
391904000301	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
391904000302	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
391904000303	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
391904000304	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
391904000305	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
391904000306	Soluble P-type ATPase [General function prediction only]; Region: COG4087
391904000307	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
391904000308	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
391904000309	putative ligand binding site [chemical binding]; other site
391904000310	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
391904000311	TM-ABC transporter signature motif; other site
391904000312	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
391904000313	TM-ABC transporter signature motif; other site
391904000314	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
391904000315	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
391904000316	Walker A/P-loop; other site
391904000317	ATP binding site [chemical binding]; other site
391904000318	Q-loop/lid; other site
391904000319	ABC transporter signature motif; other site
391904000320	Walker B; other site
391904000321	D-loop; other site
391904000322	H-loop/switch region; other site
391904000323	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
391904000324	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
391904000325	Walker A/P-loop; other site
391904000326	ATP binding site [chemical binding]; other site
391904000327	Q-loop/lid; other site
391904000328	ABC transporter signature motif; other site
391904000329	Walker B; other site
391904000330	D-loop; other site
391904000331	H-loop/switch region; other site
391904000332	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
391904000333	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
391904000334	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
391904000335	alpha-gamma subunit interface [polypeptide binding]; other site
391904000336	beta-gamma subunit interface [polypeptide binding]; other site
391904000337	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
391904000338	gamma-beta subunit interface [polypeptide binding]; other site
391904000339	alpha-beta subunit interface [polypeptide binding]; other site
391904000340	urease subunit alpha; Reviewed; Region: ureC; PRK13207
391904000341	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
391904000342	subunit interactions [polypeptide binding]; other site
391904000343	active site
391904000344	flap region; other site
391904000345	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
391904000346	dimer interface [polypeptide binding]; other site
391904000347	catalytic residues [active]
391904000348	UreF; Region: UreF; cl19817
391904000349	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
391904000350	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
391904000351	G1 box; other site
391904000352	GTP/Mg2+ binding site [chemical binding]; other site
391904000353	G2 box; other site
391904000354	Switch I region; other site
391904000355	G3 box; other site
391904000356	Switch II region; other site
391904000357	G4 box; other site
391904000358	G5 box; other site
391904000359	UreD urease accessory protein; Region: UreD; cl00530
391904000360	ferredoxin-NADP+ reductase; Region: PLN02852
391904000361	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
391904000362	heat shock protein HtpX; Provisional; Region: PRK03072
391904000363	heat shock protein HtpX; Provisional; Region: PRK01345
391904000364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000365	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904000366	putative substrate translocation pore; other site
391904000367	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
391904000368	active site
391904000369	SUMO-1 interface [polypeptide binding]; other site
391904000370	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
391904000371	active site
391904000372	intersubunit interface [polypeptide binding]; other site
391904000373	zinc binding site [ion binding]; other site
391904000374	Na+ binding site [ion binding]; other site
391904000375	AAA domain; Region: AAA_23; pfam13476
391904000376	Walker A/P-loop; other site
391904000377	ATP binding site [chemical binding]; other site
391904000378	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
391904000379	GDP-binding site [chemical binding]; other site
391904000380	ACT binding site; other site
391904000381	IMP binding site; other site
391904000382	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
391904000383	Cl- selectivity filter; other site
391904000384	Cl- binding residues [ion binding]; other site
391904000385	pore gating glutamate residue; other site
391904000386	dimer interface [polypeptide binding]; other site
391904000387	H+/Cl- coupling transport residue; other site
391904000388	TrkA-C domain; Region: TrkA_C; pfam02080
391904000389	CrcB-like protein; Region: CRCB; pfam02537
391904000390	CrcB-like protein; Region: CRCB; pfam02537
391904000391	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904000392	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904000393	DNA binding site [nucleotide binding]
391904000394	domain linker motif; other site
391904000395	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
391904000396	dimerization interface [polypeptide binding]; other site
391904000397	ligand binding site [chemical binding]; other site
391904000398	sodium binding site [ion binding]; other site
391904000399	sucrose phosphorylase; Provisional; Region: PRK13840
391904000400	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
391904000401	active site
391904000402	homodimer interface [polypeptide binding]; other site
391904000403	catalytic site [active]
391904000404	Domain of unknown function (DUF1964); Region: DUF1964; pfam09244
391904000405	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000406	PUCC protein; Region: PUCC; pfam03209
391904000407	putative substrate translocation pore; other site
391904000408	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000409	metabolite-proton symporter; Region: 2A0106; TIGR00883
391904000410	putative substrate translocation pore; other site
391904000411	ketol-acid reductoisomerase; Provisional; Region: PRK05479
391904000412	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
391904000413	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
391904000414	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
391904000415	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
391904000416	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
391904000417	Walker A/P-loop; other site
391904000418	ATP binding site [chemical binding]; other site
391904000419	Q-loop/lid; other site
391904000420	ABC transporter signature motif; other site
391904000421	Walker B; other site
391904000422	D-loop; other site
391904000423	H-loop/switch region; other site
391904000424	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
391904000425	CHY zinc finger; Region: zf-CHY; cl19861
391904000426	ketol-acid reductoisomerase; Provisional; Region: PRK05479
391904000427	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
391904000428	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
391904000429	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
391904000430	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
391904000431	active site
391904000432	catalytic site [active]
391904000433	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
391904000434	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904000435	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904000436	DNA binding site [nucleotide binding]
391904000437	domain linker motif; other site
391904000438	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904000439	ligand binding site [chemical binding]; other site
391904000440	dimerization interface [polypeptide binding]; other site
391904000441	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
391904000442	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
391904000443	alkaline phosphatase; Provisional; Region: PRK10518
391904000444	active site
391904000445	dimer interface [polypeptide binding]; other site
391904000446	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
391904000447	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
391904000448	nucleotide binding site [chemical binding]; other site
391904000449	NEF interaction site [polypeptide binding]; other site
391904000450	SBD interface [polypeptide binding]; other site
391904000451	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
391904000452	dimer interface [polypeptide binding]; other site
391904000453	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
391904000454	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
391904000455	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
391904000456	HSP70 interaction site [polypeptide binding]; other site
391904000457	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
391904000458	substrate binding site [polypeptide binding]; other site
391904000459	dimer interface [polypeptide binding]; other site
391904000460	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
391904000461	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
391904000462	DNA binding residues [nucleotide binding]
391904000463	putative dimer interface [polypeptide binding]; other site
391904000464	Sulfate transporter family; Region: Sulfate_transp; cl19250
391904000465	xanthine permease; Region: pbuX; TIGR03173
391904000466	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
391904000467	Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080
391904000468	putative catalytic cysteine [active]
391904000469	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
391904000470	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391904000471	NAD(P) binding site [chemical binding]; other site
391904000472	active site
391904000473	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
391904000474	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904000475	active site
391904000476	motif I; other site
391904000477	motif II; other site
391904000478	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
391904000479	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
391904000480	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391904000481	ATP binding site [chemical binding]; other site
391904000482	Walker B motif; other site
391904000483	Type II secretion system (T2SS), protein F; Region: T2SF; cl19503
391904000484	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
391904000485	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
391904000486	TadE-like protein; Region: TadE; pfam07811
391904000487	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
391904000488	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
391904000489	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
391904000490	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391904000491	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904000492	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
391904000493	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904000494	Walker A motif; other site
391904000495	ATP binding site [chemical binding]; other site
391904000496	Walker B motif; other site
391904000497	arginine finger; other site
391904000498	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
391904000499	recombination protein RecR; Reviewed; Region: recR; PRK00076
391904000500	RecR protein; Region: RecR; pfam02132
391904000501	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
391904000502	putative active site [active]
391904000503	putative metal-binding site [ion binding]; other site
391904000504	tetramer interface [polypeptide binding]; other site
391904000505	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
391904000506	active site
391904000507	catalytic site [active]
391904000508	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904000509	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904000510	aspartate kinase; Reviewed; Region: PRK06635
391904000511	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
391904000512	putative nucleotide binding site [chemical binding]; other site
391904000513	putative catalytic residues [active]
391904000514	putative Mg ion binding site [ion binding]; other site
391904000515	putative aspartate binding site [chemical binding]; other site
391904000516	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
391904000517	putative allosteric regulatory site; other site
391904000518	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
391904000519	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
391904000520	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
391904000521	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
391904000522	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
391904000523	putative active site [active]
391904000524	putative metal binding site [ion binding]; other site
391904000525	2-isopropylmalate synthase; Validated; Region: PRK03739
391904000526	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
391904000527	active site
391904000528	catalytic residues [active]
391904000529	metal binding site [ion binding]; metal-binding site
391904000530	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
391904000531	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
391904000532	Transglycosylase; Region: Transgly; pfam00912
391904000533	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
391904000534	TolA protein; Region: tolA_full; TIGR02794
391904000535	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
391904000536	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
391904000537	active site
391904000538	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
391904000539	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
391904000540	active site
391904000541	interdomain interaction site; other site
391904000542	putative metal-binding site [ion binding]; other site
391904000543	nucleotide binding site [chemical binding]; other site
391904000544	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
391904000545	domain I; other site
391904000546	DNA binding groove [nucleotide binding]
391904000547	phosphate binding site [ion binding]; other site
391904000548	domain II; other site
391904000549	domain III; other site
391904000550	nucleotide binding site [chemical binding]; other site
391904000551	catalytic site [active]
391904000552	domain IV; other site
391904000553	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
391904000554	thymidylate kinase; Validated; Region: tmk; PRK00698
391904000555	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
391904000556	TMP-binding site; other site
391904000557	ATP-binding site [chemical binding]; other site
391904000558	DNA polymerase III subunit delta'; Validated; Region: PRK07940
391904000559	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904000560	Walker A motif; other site
391904000561	ATP binding site [chemical binding]; other site
391904000562	Walker B motif; other site
391904000563	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904000564	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904000565	DNA binding site [nucleotide binding]
391904000566	domain linker motif; other site
391904000567	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904000568	dimerization interface [polypeptide binding]; other site
391904000569	ligand binding site [chemical binding]; other site
391904000570	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
391904000571	dimerization domain swap beta strand [polypeptide binding]; other site
391904000572	regulatory protein interface [polypeptide binding]; other site
391904000573	active site
391904000574	regulatory phosphorylation site [posttranslational modification]; other site
391904000575	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
391904000576	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
391904000577	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
391904000578	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
391904000579	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
391904000580	substrate binding site [chemical binding]; other site
391904000581	Peptidase family C69; Region: Peptidase_C69; pfam03577
391904000582	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
391904000583	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
391904000584	GtrA-like protein; Region: GtrA; pfam04138
391904000585	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
391904000586	Divergent AAA domain; Region: AAA_4; pfam04326
391904000587	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
391904000588	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
391904000589	putative DNA binding site [nucleotide binding]; other site
391904000590	putative Zn2+ binding site [ion binding]; other site
391904000591	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904000592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000593	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904000594	catalytic core [active]
391904000595	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
391904000596	active site
391904000597	phosphate binding residues; other site
391904000598	catalytic residues [active]
391904000599	Protein of unknown function (DUF805); Region: DUF805; pfam05656
391904000600	Abi-like protein; Region: Abi_2; cl01988
391904000601	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
391904000602	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
391904000603	active site
391904000604	HIGH motif; other site
391904000605	KMSKS motif; other site
391904000606	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
391904000607	Divergent AAA domain; Region: AAA_4; pfam04326
391904000608	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
391904000609	Iron permease FTR1 family; Region: FTR1; cl00475
391904000610	Fe2+ transport protein; Region: Iron_transport; pfam10634
391904000611	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
391904000612	Predicted membrane protein [Function unknown]; Region: COG4393
391904000613	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
391904000614	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904000615	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904000616	FtsX-like permease family; Region: FtsX; pfam02687
391904000617	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904000618	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
391904000619	FtsX-like permease family; Region: FtsX; pfam02687
391904000620	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904000621	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904000622	Walker A/P-loop; other site
391904000623	ATP binding site [chemical binding]; other site
391904000624	Q-loop/lid; other site
391904000625	ABC transporter signature motif; other site
391904000626	Walker B; other site
391904000627	D-loop; other site
391904000628	H-loop/switch region; other site
391904000629	FMN-binding domain; Region: FMN_bind; cl01081
391904000630	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391904000631	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904000632	Predicted membrane protein [Function unknown]; Region: COG1511
391904000633	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
391904000634	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
391904000635	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
391904000636	dimer interface [polypeptide binding]; other site
391904000637	putative CheW interface [polypeptide binding]; other site
391904000638	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
391904000639	Predicted membrane protein [Function unknown]; Region: COG1511
391904000640	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
391904000641	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
391904000642	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
391904000643	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
391904000644	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
391904000645	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
391904000646	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
391904000647	putative active site [active]
391904000648	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
391904000649	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
391904000650	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
391904000651	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
391904000652	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
391904000653	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904000654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000655	putative substrate translocation pore; other site
391904000656	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904000657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904000658	active site
391904000659	phosphorylation site [posttranslational modification]
391904000660	intermolecular recognition site; other site
391904000661	dimerization interface [polypeptide binding]; other site
391904000662	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904000663	DNA binding residues [nucleotide binding]
391904000664	dimerization interface [polypeptide binding]; other site
391904000665	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
391904000666	Peptidase family C69; Region: Peptidase_C69; pfam03577
391904000667	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391904000668	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391904000669	active site
391904000670	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391904000671	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904000672	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
391904000673	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
391904000674	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
391904000675	SRP54-type protein, GTPase domain; Region: SRP54; pfam00448
391904000676	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
391904000677	Nitrogen regulatory protein P-II; Region: P-II; smart00938
391904000678	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
391904000679	metal binding triad; other site
391904000680	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
391904000681	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
391904000682	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
391904000683	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
391904000684	replicative DNA helicase; Region: DnaB; TIGR00665
391904000685	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
391904000686	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
391904000687	Walker A motif; other site
391904000688	ATP binding site [chemical binding]; other site
391904000689	Walker B motif; other site
391904000690	DNA binding loops [nucleotide binding]
391904000691	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
391904000692	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391904000693	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
391904000694	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
391904000695	catalytic triad [active]
391904000696	Uncharacterized conserved protein [Function unknown]; Region: COG3937
391904000697	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
391904000698	active site
391904000699	ATP binding site [chemical binding]; other site
391904000700	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
391904000701	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
391904000702	catalytic residue [active]
391904000703	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
391904000704	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
391904000705	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904000706	active site
391904000707	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
391904000708	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
391904000709	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
391904000710	dimer interface [polypeptide binding]; other site
391904000711	ssDNA binding site [nucleotide binding]; other site
391904000712	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904000713	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
391904000714	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
391904000715	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
391904000716	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
391904000717	Transposase; Region: DDE_Tnp_ISL3; pfam01610
391904000718	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904000719	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
391904000720	Walker A/P-loop; other site
391904000721	ATP binding site [chemical binding]; other site
391904000722	Q-loop/lid; other site
391904000723	ABC transporter signature motif; other site
391904000724	Walker B; other site
391904000725	D-loop; other site
391904000726	H-loop/switch region; other site
391904000727	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904000728	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904000729	Walker A/P-loop; other site
391904000730	ATP binding site [chemical binding]; other site
391904000731	Q-loop/lid; other site
391904000732	ABC transporter signature motif; other site
391904000733	Walker B; other site
391904000734	D-loop; other site
391904000735	H-loop/switch region; other site
391904000736	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904000737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904000738	active site
391904000739	phosphorylation site [posttranslational modification]
391904000740	intermolecular recognition site; other site
391904000741	dimerization interface [polypeptide binding]; other site
391904000742	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904000743	DNA binding residues [nucleotide binding]
391904000744	dimerization interface [polypeptide binding]; other site
391904000745	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904000746	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000747	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904000748	putative substrate translocation pore; other site
391904000749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000750	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904000751	putative substrate translocation pore; other site
391904000752	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
391904000753	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
391904000754	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
391904000755	amphipathic channel; other site
391904000756	Asn-Pro-Ala signature motifs; other site
391904000757	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
391904000758	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
391904000759	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
391904000760	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904000761	active site
391904000762	motif I; other site
391904000763	motif II; other site
391904000764	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
391904000765	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
391904000766	putative homodimer interface [polypeptide binding]; other site
391904000767	putative homotetramer interface [polypeptide binding]; other site
391904000768	putative allosteric switch controlling residues; other site
391904000769	putative metal binding site [ion binding]; other site
391904000770	putative homodimer-homodimer interface [polypeptide binding]; other site
391904000771	RmuC family; Region: RmuC; pfam02646
391904000772	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904000773	active site
391904000774	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
391904000775	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
391904000776	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
391904000777	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
391904000778	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
391904000779	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
391904000780	GatB domain; Region: GatB_Yqey; pfam02637
391904000781	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
391904000782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
391904000783	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
391904000784	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
391904000785	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
391904000786	hypothetical protein; Provisional; Region: PRK07208
391904000787	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391904000788	UDP-galactopyranose mutase; Region: GLF; pfam03275
391904000789	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
391904000790	transcription termination factor Rho; Provisional; Region: PRK12678
391904000791	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
391904000792	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
391904000793	RNA binding site [nucleotide binding]; other site
391904000794	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391904000795	Walker A motif; other site
391904000796	ATP binding site [chemical binding]; other site
391904000797	Walker B motif; other site
391904000798	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904000799	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904000800	DNA binding site [nucleotide binding]
391904000801	domain linker motif; other site
391904000802	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904000803	dimerization interface [polypeptide binding]; other site
391904000804	ligand binding site [chemical binding]; other site
391904000805	putative symporter YagG; Provisional; Region: PRK09669; cl15392
391904000806	MFS/sugar transport protein; Region: MFS_2; pfam13347
391904000807	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
391904000808	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
391904000809	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
391904000810	Transposase, Mutator family; Region: Transposase_mut; cl19537
391904000811	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
391904000812	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904000813	DNA binding site [nucleotide binding]
391904000814	active site
391904000815	Int/Topo IB signature motif; other site
391904000816	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
391904000817	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904000818	active site
391904000819	DNA binding site [nucleotide binding]
391904000820	Int/Topo IB signature motif; other site
391904000821	chorismate mutase; Provisional; Region: PRK09239
391904000822	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
391904000823	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391904000824	active site
391904000825	nucleotide binding site [chemical binding]; other site
391904000826	HIGH motif; other site
391904000827	KMSKS motif; other site
391904000828	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
391904000829	tRNA binding surface [nucleotide binding]; other site
391904000830	anticodon binding site; other site
391904000831	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
391904000832	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
391904000833	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
391904000834	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
391904000835	minor groove reading motif; other site
391904000836	helix-hairpin-helix signature motif; other site
391904000837	substrate binding pocket [chemical binding]; other site
391904000838	active site
391904000839	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
391904000840	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904000841	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391904000842	DNA binding site [nucleotide binding]
391904000843	Predicted membrane protein [Function unknown]; Region: COG1971
391904000844	Domain of unknown function DUF; Region: DUF204; pfam02659
391904000845	Domain of unknown function DUF; Region: DUF204; pfam02659
391904000846	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
391904000847	dimer interface [polypeptide binding]; other site
391904000848	substrate binding site [chemical binding]; other site
391904000849	metal binding sites [ion binding]; metal-binding site
391904000850	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
391904000851	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
391904000852	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
391904000853	active site
391904000854	homodimer interface [polypeptide binding]; other site
391904000855	catalytic site [active]
391904000856	acceptor binding site [chemical binding]; other site
391904000857	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
391904000858	Transposase IS200 like; Region: Y1_Tnp; cl00848
391904000859	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391904000860	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
391904000861	active site
391904000862	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904000863	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
391904000864	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
391904000865	Int/Topo IB signature motif; other site
391904000866	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011
391904000867	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
391904000868	dimer interface [polypeptide binding]; other site
391904000869	ligand binding site [chemical binding]; other site
391904000870	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904000871	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904000872	non-specific DNA binding site [nucleotide binding]; other site
391904000873	salt bridge; other site
391904000874	sequence-specific DNA binding site [nucleotide binding]; other site
391904000875	Plasmid replication protein; Region: Rep_2; pfam01719
391904000876	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391904000877	Walker A motif; other site
391904000878	ATP binding site [chemical binding]; other site
391904000879	Walker B motif; other site
391904000880	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904000881	non-specific DNA binding site [nucleotide binding]; other site
391904000882	salt bridge; other site
391904000883	sequence-specific DNA binding site [nucleotide binding]; other site
391904000884	Protein of unknown function (DUF497); Region: DUF497; pfam04365
391904000885	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
391904000886	proposed active site lysine [active]
391904000887	conserved cys residue [active]
391904000888	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
391904000889	ATP synthase subunit C; Region: ATP-synt_C; cl00466
391904000890	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
391904000891	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
391904000892	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
391904000893	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
391904000894	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
391904000895	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
391904000896	beta subunit interaction interface [polypeptide binding]; other site
391904000897	Walker A motif; other site
391904000898	ATP binding site [chemical binding]; other site
391904000899	Walker B motif; other site
391904000900	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
391904000901	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
391904000902	core domain interface [polypeptide binding]; other site
391904000903	delta subunit interface [polypeptide binding]; other site
391904000904	epsilon subunit interface [polypeptide binding]; other site
391904000905	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
391904000906	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
391904000907	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
391904000908	alpha subunit interaction interface [polypeptide binding]; other site
391904000909	Walker A motif; other site
391904000910	ATP binding site [chemical binding]; other site
391904000911	Walker B motif; other site
391904000912	inhibitor binding site; inhibition site
391904000913	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
391904000914	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
391904000915	gamma subunit interface [polypeptide binding]; other site
391904000916	epsilon subunit interface [polypeptide binding]; other site
391904000917	LBP interface [polypeptide binding]; other site
391904000918	hypothetical protein; Provisional; Region: PRK03298
391904000919	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
391904000920	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
391904000921	Tetratricopeptide repeat; Region: TPR_20; pfam14561
391904000922	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
391904000923	putative active site [active]
391904000924	putative metal binding residues [ion binding]; other site
391904000925	signature motif; other site
391904000926	putative dimer interface [polypeptide binding]; other site
391904000927	putative phosphate binding site [ion binding]; other site
391904000928	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
391904000929	homotrimer interaction site [polypeptide binding]; other site
391904000930	putative active site [active]
391904000931	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
391904000932	putative acyl-acceptor binding pocket; other site
391904000933	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
391904000934	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
391904000935	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
391904000936	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
391904000937	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
391904000938	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
391904000939	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
391904000940	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000941	dimer interface [polypeptide binding]; other site
391904000942	conserved gate region; other site
391904000943	putative PBP binding loops; other site
391904000944	ABC-ATPase subunit interface; other site
391904000945	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
391904000946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904000947	dimer interface [polypeptide binding]; other site
391904000948	conserved gate region; other site
391904000949	putative PBP binding loops; other site
391904000950	ABC-ATPase subunit interface; other site
391904000951	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
391904000952	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904000953	Walker A/P-loop; other site
391904000954	ATP binding site [chemical binding]; other site
391904000955	Q-loop/lid; other site
391904000956	ABC transporter signature motif; other site
391904000957	Walker B; other site
391904000958	D-loop; other site
391904000959	H-loop/switch region; other site
391904000960	TOBE domain; Region: TOBE_2; pfam08402
391904000961	CAAX protease self-immunity; Region: Abi; pfam02517
391904000962	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
391904000963	Mechanosensitive ion channel; Region: MS_channel; pfam00924
391904000964	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
391904000965	Aspartase; Region: Aspartase; cd01357
391904000966	active sites [active]
391904000967	tetramer interface [polypeptide binding]; other site
391904000968	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391904000969	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904000970	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
391904000971	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391904000972	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
391904000973	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
391904000974	DNA binding site [nucleotide binding]
391904000975	active site
391904000976	RelB antitoxin; Region: RelB; cl01171
391904000977	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
391904000978	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
391904000979	DNA binding residues [nucleotide binding]
391904000980	dimer interface [polypeptide binding]; other site
391904000981	CpXC protein; Region: CpXC; pfam14353
391904000982	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
391904000983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904000984	putative substrate translocation pore; other site
391904000985	YegV-like sugar kinase.  Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944
391904000986	substrate binding site [chemical binding]; other site
391904000987	ATP binding site [chemical binding]; other site
391904000988	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
391904000989	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
391904000990	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
391904000991	ssDNA binding site; other site
391904000992	generic binding surface II; other site
391904000993	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904000994	ATP binding site [chemical binding]; other site
391904000995	putative Mg++ binding site [ion binding]; other site
391904000996	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904000997	nucleotide binding region [chemical binding]; other site
391904000998	ATP-binding site [chemical binding]; other site
391904000999	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904001000	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001001	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
391904001002	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001003	dimer interface [polypeptide binding]; other site
391904001004	conserved gate region; other site
391904001005	putative PBP binding loops; other site
391904001006	ABC-ATPase subunit interface; other site
391904001007	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904001008	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001009	dimer interface [polypeptide binding]; other site
391904001010	conserved gate region; other site
391904001011	putative PBP binding loops; other site
391904001012	ABC-ATPase subunit interface; other site
391904001013	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904001014	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904001015	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
391904001016	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
391904001017	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001018	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904001019	putative substrate translocation pore; other site
391904001020	Hypothetical glycosyl hydrolase 6; Region: GHL6; pfam14871
391904001021	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
391904001022	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
391904001023	Domain of unknown function (DUF3841); Region: DUF3841; pfam12952
391904001024	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
391904001025	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
391904001026	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
391904001027	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
391904001028	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904001029	S-adenosylmethionine binding site [chemical binding]; other site
391904001030	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
391904001031	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
391904001032	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
391904001033	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
391904001034	substrate binding site; other site
391904001035	dimer interface; other site
391904001036	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
391904001037	putative substrate binding pocket [chemical binding]; other site
391904001038	AC domain interface; other site
391904001039	catalytic triad [active]
391904001040	AB domain interface; other site
391904001041	interchain disulfide; other site
391904001042	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
391904001043	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
391904001044	trimer interface [polypeptide binding]; other site
391904001045	active site
391904001046	G bulge; other site
391904001047	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
391904001048	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
391904001049	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
391904001050	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001051	metabolite-proton symporter; Region: 2A0106; TIGR00883
391904001052	putative substrate translocation pore; other site
391904001053	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
391904001054	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391904001055	dimer interface [polypeptide binding]; other site
391904001056	phosphorylation site [posttranslational modification]
391904001057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904001058	ATP binding site [chemical binding]; other site
391904001059	Mg2+ binding site [ion binding]; other site
391904001060	G-X-G motif; other site
391904001061	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904001062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001063	active site
391904001064	phosphorylation site [posttranslational modification]
391904001065	intermolecular recognition site; other site
391904001066	dimerization interface [polypeptide binding]; other site
391904001067	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391904001068	DNA binding site [nucleotide binding]
391904001069	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
391904001070	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
391904001071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001072	dimer interface [polypeptide binding]; other site
391904001073	conserved gate region; other site
391904001074	putative PBP binding loops; other site
391904001075	ABC-ATPase subunit interface; other site
391904001076	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
391904001077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001078	dimer interface [polypeptide binding]; other site
391904001079	conserved gate region; other site
391904001080	putative PBP binding loops; other site
391904001081	ABC-ATPase subunit interface; other site
391904001082	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
391904001083	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
391904001084	Walker A/P-loop; other site
391904001085	ATP binding site [chemical binding]; other site
391904001086	Q-loop/lid; other site
391904001087	ABC transporter signature motif; other site
391904001088	Walker B; other site
391904001089	D-loop; other site
391904001090	H-loop/switch region; other site
391904001091	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
391904001092	Predicted membrane protein (DUF2207); Region: DUF2207; cl19878
391904001093	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904001094	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
391904001095	active site
391904001096	catalytic tetrad [active]
391904001097	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
391904001098	active site
391904001099	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001100	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904001101	DNA binding site [nucleotide binding]
391904001102	domain linker motif; other site
391904001103	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904001104	dimerization interface [polypeptide binding]; other site
391904001105	ligand binding site [chemical binding]; other site
391904001106	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904001107	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
391904001108	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001109	dimer interface [polypeptide binding]; other site
391904001110	conserved gate region; other site
391904001111	putative PBP binding loops; other site
391904001112	ABC-ATPase subunit interface; other site
391904001113	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904001114	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001115	dimer interface [polypeptide binding]; other site
391904001116	conserved gate region; other site
391904001117	putative PBP binding loops; other site
391904001118	ABC-ATPase subunit interface; other site
391904001119	HipA N-terminal domain; Region: Couple_hipA; cl11853
391904001120	HipA-like N-terminal domain; Region: HipA_N; pfam07805
391904001121	HipA-like C-terminal domain; Region: HipA_C; pfam07804
391904001122	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904001123	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904001124	non-specific DNA binding site [nucleotide binding]; other site
391904001125	salt bridge; other site
391904001126	sequence-specific DNA binding site [nucleotide binding]; other site
391904001127	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
391904001128	RimM N-terminal domain; Region: RimM; pfam01782
391904001129	hypothetical protein; Provisional; Region: PRK02821
391904001130	G-X-X-G motif; other site
391904001131	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521
391904001132	ribosomal protein S16; Region: S16; TIGR00002
391904001133	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
391904001134	homodimer interface [polypeptide binding]; other site
391904001135	substrate-cofactor binding pocket; other site
391904001136	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904001137	catalytic residue [active]
391904001138	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
391904001139	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
391904001140	chorismate binding enzyme; Region: Chorismate_bind; cl10555
391904001141	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
391904001142	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
391904001143	catalytic motif [active]
391904001144	Zn binding site [ion binding]; other site
391904001145	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
391904001146	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
391904001147	Lumazine binding domain; Region: Lum_binding; pfam00677
391904001148	Lumazine binding domain; Region: Lum_binding; pfam00677
391904001149	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
391904001150	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
391904001151	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
391904001152	dimerization interface [polypeptide binding]; other site
391904001153	active site
391904001154	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
391904001155	homopentamer interface [polypeptide binding]; other site
391904001156	active site
391904001157	Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372
391904001158	putative catalytic site [active]
391904001159	putative metal binding site [ion binding]; other site
391904001160	putative phosphate binding site [ion binding]; other site
391904001161	signal recognition particle protein; Provisional; Region: PRK10867
391904001162	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
391904001163	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
391904001164	P loop; other site
391904001165	GTP binding site [chemical binding]; other site
391904001166	Signal peptide binding domain; Region: SRP_SPB; pfam02978
391904001167	Cation efflux family; Region: Cation_efflux; pfam01545
391904001168	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
391904001169	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
391904001170	active site
391904001171	HIGH motif; other site
391904001172	KMSKS motif; other site
391904001173	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
391904001174	tRNA binding surface [nucleotide binding]; other site
391904001175	anticodon binding site; other site
391904001176	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
391904001177	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
391904001178	catalytic triad [active]
391904001179	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
391904001180	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904001181	ABC transporter; Region: ABC_tran_2; pfam12848
391904001182	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904001183	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
391904001184	oligomeric interface; other site
391904001185	putative active site [active]
391904001186	homodimer interface [polypeptide binding]; other site
391904001187	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
391904001188	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
391904001189	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
391904001190	putative valine binding site [chemical binding]; other site
391904001191	dimer interface [polypeptide binding]; other site
391904001192	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
391904001193	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
391904001194	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
391904001195	PYR/PP interface [polypeptide binding]; other site
391904001196	dimer interface [polypeptide binding]; other site
391904001197	TPP binding site [chemical binding]; other site
391904001198	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
391904001199	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
391904001200	TPP-binding site [chemical binding]; other site
391904001201	dimer interface [polypeptide binding]; other site
391904001202	ribonuclease III; Reviewed; Region: rnc; PRK00102
391904001203	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
391904001204	dimerization interface [polypeptide binding]; other site
391904001205	active site
391904001206	metal binding site [ion binding]; metal-binding site
391904001207	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
391904001208	dsRNA binding site [nucleotide binding]; other site
391904001209	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
391904001210	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
391904001211	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
391904001212	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
391904001213	active site
391904001214	(T/H)XGH motif; other site
391904001215	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
391904001216	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904001217	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
391904001218	active site
391904001219	catalytic tetrad [active]
391904001220	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
391904001221	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
391904001222	DNA binding residues [nucleotide binding]
391904001223	putative dimer interface [polypeptide binding]; other site
391904001224	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
391904001225	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
391904001226	active site
391904001227	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904001228	non-specific DNA binding site [nucleotide binding]; other site
391904001229	salt bridge; other site
391904001230	sequence-specific DNA binding site [nucleotide binding]; other site
391904001231	ribonuclease PH; Reviewed; Region: rph; PRK00173
391904001232	Ribonuclease PH; Region: RNase_PH_bact; cd11362
391904001233	hexamer interface [polypeptide binding]; other site
391904001234	active site
391904001235	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
391904001236	active site
391904001237	dimerization interface [polypeptide binding]; other site
391904001238	FemAB family; Region: FemAB; pfam02388
391904001239	FemAB family; Region: FemAB; pfam02388
391904001240	FemAB family; Region: FemAB; pfam02388
391904001241	Membrane transport protein; Region: Mem_trans; cl09117
391904001242	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
391904001243	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
391904001244	active site
391904001245	dimer interface [polypeptide binding]; other site
391904001246	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
391904001247	dimer interface [polypeptide binding]; other site
391904001248	active site
391904001249	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
391904001250	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
391904001251	Walker A/P-loop; other site
391904001252	ATP binding site [chemical binding]; other site
391904001253	Q-loop/lid; other site
391904001254	ABC transporter signature motif; other site
391904001255	Walker B; other site
391904001256	D-loop; other site
391904001257	H-loop/switch region; other site
391904001258	C-terminal AAA-associated domain; Region: AAA_assoc_C; cl15413
391904001259	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
391904001260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001261	dimer interface [polypeptide binding]; other site
391904001262	conserved gate region; other site
391904001263	putative PBP binding loops; other site
391904001264	ABC-ATPase subunit interface; other site
391904001265	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001266	dimer interface [polypeptide binding]; other site
391904001267	conserved gate region; other site
391904001268	putative PBP binding loops; other site
391904001269	ABC-ATPase subunit interface; other site
391904001270	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
391904001271	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
391904001272	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
391904001273	Catalytic site [active]
391904001274	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
391904001275	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
391904001276	RNA/DNA hybrid binding site [nucleotide binding]; other site
391904001277	active site
391904001278	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001279	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904001280	DNA binding site [nucleotide binding]
391904001281	domain linker motif; other site
391904001282	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
391904001283	ligand binding site [chemical binding]; other site
391904001284	dimerization interface (open form) [polypeptide binding]; other site
391904001285	dimerization interface (closed form) [polypeptide binding]; other site
391904001286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001287	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904001288	putative substrate translocation pore; other site
391904001289	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
391904001290	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
391904001291	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
391904001292	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
391904001293	acyl-activating enzyme (AAE) consensus motif; other site
391904001294	putative AMP binding site [chemical binding]; other site
391904001295	putative active site [active]
391904001296	putative CoA binding site [chemical binding]; other site
391904001297	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
391904001298	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001299	putative substrate translocation pore; other site
391904001300	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904001301	UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337
391904001302	Histidine kinase; Region: HisKA_3; pfam07730
391904001303	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904001304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001305	active site
391904001306	phosphorylation site [posttranslational modification]
391904001307	intermolecular recognition site; other site
391904001308	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904001309	DNA binding residues [nucleotide binding]
391904001310	dimerization interface [polypeptide binding]; other site
391904001311	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
391904001312	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001313	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
391904001314	Walker A/P-loop; other site
391904001315	ATP binding site [chemical binding]; other site
391904001316	Q-loop/lid; other site
391904001317	ABC transporter signature motif; other site
391904001318	Walker B; other site
391904001319	D-loop; other site
391904001320	H-loop/switch region; other site
391904001321	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
391904001322	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001323	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904001324	DNA binding site [nucleotide binding]
391904001325	domain linker motif; other site
391904001326	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904001327	ligand binding site [chemical binding]; other site
391904001328	dimerization interface [polypeptide binding]; other site
391904001329	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
391904001330	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
391904001331	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904001332	active site
391904001333	catalytic tetrad [active]
391904001334	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
391904001335	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
391904001336	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
391904001337	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001338	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904001339	putative substrate translocation pore; other site
391904001340	AAA ATPase domain; Region: AAA_16; pfam13191
391904001341	Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896
391904001342	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904001343	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904001344	Integrase core domain; Region: rve; pfam00665
391904001345	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904001346	Helix-turn-helix domain; Region: HTH_17; pfam12728
391904001347	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
391904001348	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
391904001349	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659
391904001350	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904001351	active site
391904001352	DNA binding site [nucleotide binding]
391904001353	Int/Topo IB signature motif; other site
391904001354	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
391904001355	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
391904001356	putative active site [active]
391904001357	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904001358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001359	dimer interface [polypeptide binding]; other site
391904001360	conserved gate region; other site
391904001361	putative PBP binding loops; other site
391904001362	ABC-ATPase subunit interface; other site
391904001363	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904001364	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001365	active site
391904001366	phosphorylation site [posttranslational modification]
391904001367	intermolecular recognition site; other site
391904001368	dimerization interface [polypeptide binding]; other site
391904001369	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
391904001370	DNA binding residues [nucleotide binding]
391904001371	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904001372	Histidine kinase; Region: HisKA_3; pfam07730
391904001373	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
391904001374	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952
391904001375	FtsX-like permease family; Region: FtsX; pfam02687
391904001376	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904001377	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904001378	Walker A/P-loop; other site
391904001379	ATP binding site [chemical binding]; other site
391904001380	Q-loop/lid; other site
391904001381	ABC transporter signature motif; other site
391904001382	Walker B; other site
391904001383	D-loop; other site
391904001384	H-loop/switch region; other site
391904001385	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
391904001386	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
391904001387	active site
391904001388	substrate binding site [chemical binding]; other site
391904001389	ATP binding site [chemical binding]; other site
391904001390	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
391904001391	activation loop (A-loop); other site
391904001392	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
391904001393	active site
391904001394	zinc binding site [ion binding]; other site
391904001395	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904001396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001397	active site
391904001398	phosphorylation site [posttranslational modification]
391904001399	intermolecular recognition site; other site
391904001400	dimerization interface [polypeptide binding]; other site
391904001401	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
391904001402	DNA binding residues [nucleotide binding]
391904001403	dimerization interface [polypeptide binding]; other site
391904001404	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904001405	Histidine kinase; Region: HisKA_3; pfam07730
391904001406	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
391904001407	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904001408	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904001409	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904001410	Walker A/P-loop; other site
391904001411	ATP binding site [chemical binding]; other site
391904001412	Q-loop/lid; other site
391904001413	ABC transporter signature motif; other site
391904001414	Walker B; other site
391904001415	D-loop; other site
391904001416	H-loop/switch region; other site
391904001417	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904001418	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904001419	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001420	Walker A/P-loop; other site
391904001421	ATP binding site [chemical binding]; other site
391904001422	Q-loop/lid; other site
391904001423	ABC transporter signature motif; other site
391904001424	Walker B; other site
391904001425	D-loop; other site
391904001426	H-loop/switch region; other site
391904001427	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
391904001428	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
391904001429	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
391904001430	Ligand Binding Site [chemical binding]; other site
391904001431	Molecular Tunnel; other site
391904001432	CutC family; Region: CutC; cl01218
391904001433	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001434	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
391904001435	Walker A/P-loop; other site
391904001436	ATP binding site [chemical binding]; other site
391904001437	Q-loop/lid; other site
391904001438	ABC transporter signature motif; other site
391904001439	Walker B; other site
391904001440	D-loop; other site
391904001441	H-loop/switch region; other site
391904001442	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904001443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001444	active site
391904001445	phosphorylation site [posttranslational modification]
391904001446	intermolecular recognition site; other site
391904001447	dimerization interface [polypeptide binding]; other site
391904001448	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904001449	DNA binding residues [nucleotide binding]
391904001450	dimerization interface [polypeptide binding]; other site
391904001451	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904001452	Histidine kinase; Region: HisKA_3; pfam07730
391904001453	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
391904001454	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
391904001455	Integral membrane protein DUF95; Region: DUF95; cl00572
391904001456	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904001457	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391904001458	Walker A/P-loop; other site
391904001459	ATP binding site [chemical binding]; other site
391904001460	Q-loop/lid; other site
391904001461	ABC transporter signature motif; other site
391904001462	Walker B; other site
391904001463	D-loop; other site
391904001464	3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640
391904001465	H-loop/switch region; other site
391904001466	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904001467	active site
391904001468	Int/Topo IB signature motif; other site
391904001469	DNA binding site [nucleotide binding]
391904001470	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
391904001471	FAD binding pocket [chemical binding]; other site
391904001472	conserved FAD binding motif [chemical binding]; other site
391904001473	phosphate binding motif [ion binding]; other site
391904001474	beta-alpha-beta structure motif; other site
391904001475	NAD binding pocket [chemical binding]; other site
391904001476	aspartate aminotransferase; Provisional; Region: PRK05764
391904001477	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904001478	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904001479	homodimer interface [polypeptide binding]; other site
391904001480	catalytic residue [active]
391904001481	pyrrolysine biosynthesis protein PylC; Region: pyrrolys_PylC; TIGR03909
391904001482	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
391904001483	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
391904001484	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001485	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904001486	putative substrate translocation pore; other site
391904001487	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
391904001488	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
391904001489	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904001490	Transposase; Region: HTH_Tnp_1; cl17663
391904001491	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904001492	putative transposase OrfB; Reviewed; Region: PHA02517
391904001493	HTH-like domain; Region: HTH_21; pfam13276
391904001494	Integrase core domain; Region: rve; pfam00665
391904001495	Integrase core domain; Region: rve_2; pfam13333
391904001496	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904001497	active site
391904001498	Int/Topo IB signature motif; other site
391904001499	DNA binding site [nucleotide binding]
391904001500	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
391904001501	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904001502	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904001503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001504	active site
391904001505	phosphorylation site [posttranslational modification]
391904001506	intermolecular recognition site; other site
391904001507	dimerization interface [polypeptide binding]; other site
391904001508	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904001509	DNA binding residues [nucleotide binding]
391904001510	dimerization interface [polypeptide binding]; other site
391904001511	PrgI family protein; Region: PrgI; pfam12666
391904001512	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391904001513	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904001514	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391904001515	HAMP domain; Region: HAMP; pfam00672
391904001516	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391904001517	dimer interface [polypeptide binding]; other site
391904001518	phosphorylation site [posttranslational modification]
391904001519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904001520	ATP binding site [chemical binding]; other site
391904001521	Mg2+ binding site [ion binding]; other site
391904001522	G-X-G motif; other site
391904001523	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904001524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904001525	active site
391904001526	phosphorylation site [posttranslational modification]
391904001527	intermolecular recognition site; other site
391904001528	dimerization interface [polypeptide binding]; other site
391904001529	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
391904001530	DNA binding site [nucleotide binding]
391904001531	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
391904001532	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
391904001533	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001534	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904001535	Walker A/P-loop; other site
391904001536	ATP binding site [chemical binding]; other site
391904001537	Q-loop/lid; other site
391904001538	ABC transporter signature motif; other site
391904001539	Walker B; other site
391904001540	D-loop; other site
391904001541	H-loop/switch region; other site
391904001542	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001543	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904001544	DNA binding site [nucleotide binding]
391904001545	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904001546	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
391904001547	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001548	Walker A/P-loop; other site
391904001549	ATP binding site [chemical binding]; other site
391904001550	Q-loop/lid; other site
391904001551	ABC transporter signature motif; other site
391904001552	Walker B; other site
391904001553	D-loop; other site
391904001554	H-loop/switch region; other site
391904001555	Sulfatase; Region: Sulfatase; cl19157
391904001556	SpaB C-terminal domain; Region: SpaB_C; pfam14028
391904001557	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
391904001558	active site
391904001559	zinc binding site [ion binding]; other site
391904001560	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391904001561	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
391904001562	Walker A/P-loop; other site
391904001563	ATP binding site [chemical binding]; other site
391904001564	Q-loop/lid; other site
391904001565	ABC transporter signature motif; other site
391904001566	Walker B; other site
391904001567	D-loop; other site
391904001568	H-loop/switch region; other site
391904001569	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
391904001570	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
391904001571	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904001572	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904001573	non-specific DNA binding site [nucleotide binding]; other site
391904001574	salt bridge; other site
391904001575	sequence-specific DNA binding site [nucleotide binding]; other site
391904001576	Domain of unknown function (DUF955); Region: DUF955; cl01076
391904001577	hypothetical protein; Region: PHA01623
391904001578	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
391904001579	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
391904001580	P-loop; other site
391904001581	Magnesium ion binding site [ion binding]; other site
391904001582	Transcription factor WhiB; Region: Whib; pfam02467
391904001583	Helix-turn-helix domain; Region: HTH_36; pfam13730
391904001584	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904001585	non-specific DNA binding site [nucleotide binding]; other site
391904001586	salt bridge; other site
391904001587	sequence-specific DNA binding site [nucleotide binding]; other site
391904001588	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
391904001589	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
391904001590	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391904001591	NAD(P) binding site [chemical binding]; other site
391904001592	active site
391904001593	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
391904001594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904001595	S-adenosylmethionine binding site [chemical binding]; other site
391904001596	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
391904001597	dimer interface [polypeptide binding]; other site
391904001598	active site
391904001599	metal binding site [ion binding]; metal-binding site
391904001600	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
391904001601	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391904001602	active site
391904001603	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391904001604	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
391904001605	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
391904001606	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
391904001607	DXD motif; other site
391904001608	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
391904001609	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391904001610	Walker A/P-loop; other site
391904001611	ATP binding site [chemical binding]; other site
391904001612	Q-loop/lid; other site
391904001613	ABC transporter signature motif; other site
391904001614	Walker B; other site
391904001615	D-loop; other site
391904001616	H-loop/switch region; other site
391904001617	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
391904001618	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
391904001619	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
391904001620	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
391904001621	Ligand Binding Site [chemical binding]; other site
391904001622	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904001623	active site
391904001624	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
391904001625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904001626	Walker A motif; other site
391904001627	ATP binding site [chemical binding]; other site
391904001628	Walker B motif; other site
391904001629	arginine finger; other site
391904001630	Peptidase family M41; Region: Peptidase_M41; pfam01434
391904001631	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
391904001632	active site
391904001633	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
391904001634	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
391904001635	substrate binding pocket [chemical binding]; other site
391904001636	dimer interface [polypeptide binding]; other site
391904001637	inhibitor binding site; inhibition site
391904001638	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
391904001639	homooctamer interface [polypeptide binding]; other site
391904001640	active site
391904001641	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
391904001642	catalytic center binding site [active]
391904001643	ATP binding site [chemical binding]; other site
391904001644	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
391904001645	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
391904001646	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
391904001647	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
391904001648	active site
391904001649	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
391904001650	catalytic triad [active]
391904001651	dimer interface [polypeptide binding]; other site
391904001652	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
391904001653	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904001654	ABC transporter; Region: ABC_tran_2; pfam12848
391904001655	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904001656	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001657	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904001658	putative substrate translocation pore; other site
391904001659	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904001660	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904001661	Walker A/P-loop; other site
391904001662	ATP binding site [chemical binding]; other site
391904001663	Q-loop/lid; other site
391904001664	ABC transporter signature motif; other site
391904001665	Walker B; other site
391904001666	D-loop; other site
391904001667	H-loop/switch region; other site
391904001668	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904001669	FtsX-like permease family; Region: FtsX; pfam02687
391904001670	FtsX-like permease family; Region: FtsX; pfam02687
391904001671	Predicted transcriptional regulators [Transcription]; Region: COG1695
391904001672	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904001673	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904001674	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904001675	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
391904001676	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001677	putative substrate translocation pore; other site
391904001678	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
391904001679	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904001680	nucleotide binding site [chemical binding]; other site
391904001681	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904001682	active site
391904001683	catalytic tetrad [active]
391904001684	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
391904001685	active site
391904001686	catalytic residues [active]
391904001687	metal binding site [ion binding]; metal-binding site
391904001688	Butyrate kinase [Energy production and conversion]; Region: COG3426
391904001689	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
391904001690	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
391904001691	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904001692	nucleotide binding site [chemical binding]; other site
391904001693	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904001694	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904001695	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904001696	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
391904001697	peptide chain release factor 1; Validated; Region: prfA; PRK00591
391904001698	This domain is found in peptide chain release factors; Region: PCRF; smart00937
391904001699	RF-1 domain; Region: RF-1; pfam00472
391904001700	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
391904001701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904001702	S-adenosylmethionine binding site [chemical binding]; other site
391904001703	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
391904001704	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
391904001705	putative ligand binding site [chemical binding]; other site
391904001706	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
391904001707	TM-ABC transporter signature motif; other site
391904001708	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
391904001709	TM-ABC transporter signature motif; other site
391904001710	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
391904001711	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
391904001712	Walker A/P-loop; other site
391904001713	ATP binding site [chemical binding]; other site
391904001714	Q-loop/lid; other site
391904001715	ABC transporter signature motif; other site
391904001716	Walker B; other site
391904001717	D-loop; other site
391904001718	H-loop/switch region; other site
391904001719	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
391904001720	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
391904001721	Walker A/P-loop; other site
391904001722	ATP binding site [chemical binding]; other site
391904001723	Q-loop/lid; other site
391904001724	ABC transporter signature motif; other site
391904001725	Walker B; other site
391904001726	D-loop; other site
391904001727	H-loop/switch region; other site
391904001728	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
391904001729	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
391904001730	Mg++ binding site [ion binding]; other site
391904001731	putative catalytic motif [active]
391904001732	substrate binding site [chemical binding]; other site
391904001733	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
391904001734	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
391904001735	active site
391904001736	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
391904001737	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
391904001738	catalytic site [active]
391904001739	putative active site [active]
391904001740	putative substrate binding site [chemical binding]; other site
391904001741	dimer interface [polypeptide binding]; other site
391904001742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904001743	PIF1-like helicase; Region: PIF1; pfam05970
391904001744	Walker A motif; other site
391904001745	ATP binding site [chemical binding]; other site
391904001746	Walker B motif; other site
391904001747	arginine finger; other site
391904001748	prolyl-tRNA synthetase; Provisional; Region: PRK09194
391904001749	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
391904001750	dimer interface [polypeptide binding]; other site
391904001751	motif 1; other site
391904001752	active site
391904001753	motif 2; other site
391904001754	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
391904001755	putative deacylase active site [active]
391904001756	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
391904001757	active site
391904001758	motif 3; other site
391904001759	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
391904001760	anticodon binding site; other site
391904001761	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
391904001762	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
391904001763	dimer interface [polypeptide binding]; other site
391904001764	ssDNA binding site [nucleotide binding]; other site
391904001765	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904001766	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
391904001767	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
391904001768	active site
391904001769	Zn binding site [ion binding]; other site
391904001770	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
391904001771	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
391904001772	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
391904001773	active site
391904001774	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
391904001775	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
391904001776	oxalacetate binding site [chemical binding]; other site
391904001777	citrylCoA binding site [chemical binding]; other site
391904001778	coenzyme A binding site [chemical binding]; other site
391904001779	catalytic triad [active]
391904001780	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
391904001781	Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N; pfam14790
391904001782	Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789
391904001783	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
391904001784	putative trimer interface [polypeptide binding]; other site
391904001785	putative CoA binding site [chemical binding]; other site
391904001786	Penicillinase repressor; Region: Penicillinase_R; cl17580
391904001787	WYL domain; Region: WYL; pfam13280
391904001788	SWIM zinc finger; Region: SWIM; pfam04434
391904001789	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
391904001790	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
391904001791	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904001792	ATP binding site [chemical binding]; other site
391904001793	putative Mg++ binding site [ion binding]; other site
391904001794	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904001795	nucleotide binding region [chemical binding]; other site
391904001796	ATP-binding site [chemical binding]; other site
391904001797	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
391904001798	additional DNA contacts [nucleotide binding]; other site
391904001799	mismatch recognition site; other site
391904001800	active site
391904001801	zinc binding site [ion binding]; other site
391904001802	DNA intercalation site [nucleotide binding]; other site
391904001803	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
391904001804	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
391904001805	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
391904001806	aminotransferase; Validated; Region: PRK07337
391904001807	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904001808	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904001809	homodimer interface [polypeptide binding]; other site
391904001810	catalytic residue [active]
391904001811	Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372
391904001812	putative catalytic site [active]
391904001813	putative metal binding site [ion binding]; other site
391904001814	putative phosphate binding site [ion binding]; other site
391904001815	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
391904001816	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
391904001817	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
391904001818	acyl-activating enzyme (AAE) consensus motif; other site
391904001819	putative AMP binding site [chemical binding]; other site
391904001820	putative active site [active]
391904001821	putative CoA binding site [chemical binding]; other site
391904001822	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
391904001823	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
391904001824	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
391904001825	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
391904001826	generic binding surface II; other site
391904001827	generic binding surface I; other site
391904001828	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
391904001829	ATP cone domain; Region: ATP-cone; pfam03477
391904001830	Class III ribonucleotide reductase; Region: RNR_III; cd01675
391904001831	effector binding site; other site
391904001832	active site
391904001833	Zn binding site [ion binding]; other site
391904001834	glycine loop; other site
391904001835	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
391904001836	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
391904001837	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
391904001838	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
391904001839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
391904001840	Mcm10 replication factor; Region: Mcm10; pfam09332
391904001841	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
391904001842	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
391904001843	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
391904001844	catalytic residues [active]
391904001845	catalytic nucleophile [active]
391904001846	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
391904001847	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
391904001848	Probable transposase; Region: OrfB_IS605; pfam01385
391904001849	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
391904001850	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
391904001851	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
391904001852	active site
391904001853	NTP binding site [chemical binding]; other site
391904001854	metal binding triad [ion binding]; metal-binding site
391904001855	antibiotic binding site [chemical binding]; other site
391904001856	nucleotidyltransferase substrate binding protein, HI0074 family; Region: HI0074; TIGR01987
391904001857	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
391904001858	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904001859	Transposase; Region: HTH_Tnp_1; cl17663
391904001860	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904001861	putative transposase OrfB; Reviewed; Region: PHA02517
391904001862	HTH-like domain; Region: HTH_21; pfam13276
391904001863	Integrase core domain; Region: rve; pfam00665
391904001864	Integrase core domain; Region: rve_2; pfam13333
391904001865	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
391904001866	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904001867	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
391904001868	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
391904001869	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
391904001870	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
391904001871	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391904001872	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
391904001873	GAF domain; Region: GAF_3; pfam13492
391904001874	Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960
391904001875	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924
391904001876	NodB motif; other site
391904001877	putative active site [active]
391904001878	putative catalytic site [active]
391904001879	putative Zn binding site [ion binding]; other site
391904001880	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
391904001881	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391904001882	Predicted membrane protein [Function unknown]; Region: COG4267
391904001883	CotH protein; Region: CotH; pfam08757
391904001884	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
391904001885	putative metal binding residues [ion binding]; other site
391904001886	signature motif; other site
391904001887	dimer interface [polypeptide binding]; other site
391904001888	active site
391904001889	polyP binding site; other site
391904001890	substrate binding site [chemical binding]; other site
391904001891	acceptor-phosphate pocket; other site
391904001892	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
391904001893	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
391904001894	metal binding site [ion binding]; metal-binding site
391904001895	active site
391904001896	I-site; other site
391904001897	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904001898	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904001899	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904001900	Walker A/P-loop; other site
391904001901	ATP binding site [chemical binding]; other site
391904001902	Q-loop/lid; other site
391904001903	ABC transporter signature motif; other site
391904001904	Walker B; other site
391904001905	D-loop; other site
391904001906	H-loop/switch region; other site
391904001907	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904001908	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904001909	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
391904001910	Walker A/P-loop; other site
391904001911	ATP binding site [chemical binding]; other site
391904001912	Q-loop/lid; other site
391904001913	ABC transporter signature motif; other site
391904001914	Walker B; other site
391904001915	D-loop; other site
391904001916	H-loop/switch region; other site
391904001917	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001918	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904001919	DNA binding site [nucleotide binding]
391904001920	domain linker motif; other site
391904001921	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904001922	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
391904001923	active site
391904001924	tetramer interface [polypeptide binding]; other site
391904001925	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904001926	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904001927	putative substrate translocation pore; other site
391904001928	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
391904001929	substrate binding site [chemical binding]; other site
391904001930	dimer interface [polypeptide binding]; other site
391904001931	ATP binding site [chemical binding]; other site
391904001932	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904001933	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904001934	DNA binding site [nucleotide binding]
391904001935	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
391904001936	putative dimerization interface [polypeptide binding]; other site
391904001937	putative ligand binding site [chemical binding]; other site
391904001938	Transcriptional regulators [Transcription]; Region: FadR; COG2186
391904001939	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
391904001940	DNA-binding site [nucleotide binding]; DNA binding site
391904001941	FCD domain; Region: FCD; pfam07729
391904001942	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904001943	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904001944	nucleotide binding site [chemical binding]; other site
391904001945	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904001946	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
391904001947	putative active site cavity [active]
391904001948	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
391904001949	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
391904001950	catalytic site [active]
391904001951	Asp-box motif; other site
391904001952	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
391904001953	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
391904001954	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904001955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001956	dimer interface [polypeptide binding]; other site
391904001957	conserved gate region; other site
391904001958	putative PBP binding loops; other site
391904001959	ABC-ATPase subunit interface; other site
391904001960	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904001961	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
391904001962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904001963	dimer interface [polypeptide binding]; other site
391904001964	conserved gate region; other site
391904001965	putative PBP binding loops; other site
391904001966	ABC-ATPase subunit interface; other site
391904001967	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
391904001968	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904001969	Walker A/P-loop; other site
391904001970	ATP binding site [chemical binding]; other site
391904001971	Q-loop/lid; other site
391904001972	ABC transporter signature motif; other site
391904001973	Walker B; other site
391904001974	D-loop; other site
391904001975	H-loop/switch region; other site
391904001976	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
391904001977	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
391904001978	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904001979	Walker A/P-loop; other site
391904001980	ATP binding site [chemical binding]; other site
391904001981	Q-loop/lid; other site
391904001982	ABC transporter signature motif; other site
391904001983	Walker B; other site
391904001984	D-loop; other site
391904001985	H-loop/switch region; other site
391904001986	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904001987	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
391904001988	inhibitor site; inhibition site
391904001989	active site
391904001990	dimer interface [polypeptide binding]; other site
391904001991	catalytic residue [active]
391904001992	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
391904001993	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904001994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904001995	homodimer interface [polypeptide binding]; other site
391904001996	catalytic residue [active]
391904001997	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
391904001998	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391904001999	active site
391904002000	HIGH motif; other site
391904002001	nucleotide binding site [chemical binding]; other site
391904002002	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
391904002003	active site
391904002004	KMSKS motif; other site
391904002005	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
391904002006	tRNA binding surface [nucleotide binding]; other site
391904002007	anticodon binding site; other site
391904002008	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
391904002009	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
391904002010	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002011	dimer interface [polypeptide binding]; other site
391904002012	conserved gate region; other site
391904002013	putative PBP binding loops; other site
391904002014	ABC-ATPase subunit interface; other site
391904002015	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
391904002016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904002017	Walker A/P-loop; other site
391904002018	ATP binding site [chemical binding]; other site
391904002019	Q-loop/lid; other site
391904002020	ABC transporter signature motif; other site
391904002021	Walker B; other site
391904002022	D-loop; other site
391904002023	H-loop/switch region; other site
391904002024	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
391904002025	Sulfatase; Region: Sulfatase; cl19157
391904002026	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
391904002027	Transposase, Mutator family; Region: Transposase_mut; cl19537
391904002028	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
391904002029	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904002030	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
391904002031	putative symporter YagG; Provisional; Region: PRK09669; cl15392
391904002032	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904002033	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904002034	DNA binding site [nucleotide binding]
391904002035	domain linker motif; other site
391904002036	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904002037	dimerization interface [polypeptide binding]; other site
391904002038	ligand binding site [chemical binding]; other site
391904002039	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904002040	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904002041	DNA binding site [nucleotide binding]
391904002042	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904002043	dimerization interface [polypeptide binding]; other site
391904002044	ligand binding site [chemical binding]; other site
391904002045	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
391904002046	AAA domain; Region: AAA_33; pfam13671
391904002047	ATP-binding site [chemical binding]; other site
391904002048	Gluconate-6-phosphate binding site [chemical binding]; other site
391904002049	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
391904002050	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
391904002051	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
391904002052	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
391904002053	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
391904002054	metal binding site [ion binding]; metal-binding site
391904002055	substrate binding pocket [chemical binding]; other site
391904002056	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
391904002057	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
391904002058	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
391904002059	glucuronate isomerase; Reviewed; Region: PRK02925
391904002060	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
391904002061	nucleotide binding site/active site [active]
391904002062	HIT family signature motif; other site
391904002063	catalytic residue [active]
391904002064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904002065	Transposase; Region: HTH_Tnp_1; cl17663
391904002066	Integrase core domain; Region: rve; pfam00665
391904002067	Integrase core domain; Region: rve_3; pfam13683
391904002068	Fusaric acid resistance protein family; Region: FUSC; pfam04632
391904002069	transposase/IS protein; Provisional; Region: PRK09183
391904002070	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904002071	Walker A motif; other site
391904002072	ATP binding site [chemical binding]; other site
391904002073	Walker B motif; other site
391904002074	Bacteriophage SPO1-encoded TF1 binds and bends DNA; Region: SPO1_TF1_like; cd14435
391904002075	putative DNA binding site [nucleotide binding]; other site
391904002076	dimer interface [polypeptide binding]; other site
391904002077	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
391904002078	active site
391904002079	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
391904002080	adenylosuccinate lyase; Provisional; Region: PRK09285
391904002081	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
391904002082	tetramer interface [polypeptide binding]; other site
391904002083	active site
391904002084	Putative lysophospholipase; Region: Hydrolase_4; cl19140
391904002085	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
391904002086	metal ion-dependent adhesion site (MIDAS); other site
391904002087	von Willebrand factor type A domain; Region: VWA_2; pfam13519
391904002088	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
391904002089	Protein of unknown function DUF58; Region: DUF58; pfam01882
391904002090	MoxR-like ATPases [General function prediction only]; Region: COG0714
391904002091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904002092	Walker A motif; other site
391904002093	ATP binding site [chemical binding]; other site
391904002094	Walker B motif; other site
391904002095	arginine finger; other site
391904002096	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
391904002097	ligand binding site [chemical binding]; other site
391904002098	active site
391904002099	UGI interface [polypeptide binding]; other site
391904002100	catalytic site [active]
391904002101	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
391904002102	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
391904002103	DNA-binding site [nucleotide binding]; DNA binding site
391904002104	RNA-binding motif; other site
391904002105	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
391904002106	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
391904002107	ring oligomerisation interface [polypeptide binding]; other site
391904002108	ATP/Mg binding site [chemical binding]; other site
391904002109	stacking interactions; other site
391904002110	hinge regions; other site
391904002111	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
391904002112	TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535
391904002113	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904002114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904002115	active site
391904002116	phosphorylation site [posttranslational modification]
391904002117	intermolecular recognition site; other site
391904002118	dimerization interface [polypeptide binding]; other site
391904002119	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391904002120	DNA binding site [nucleotide binding]
391904002121	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391904002122	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
391904002123	dimerization interface [polypeptide binding]; other site
391904002124	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391904002125	dimer interface [polypeptide binding]; other site
391904002126	phosphorylation site [posttranslational modification]
391904002127	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904002128	ATP binding site [chemical binding]; other site
391904002129	Mg2+ binding site [ion binding]; other site
391904002130	G-X-G motif; other site
391904002131	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
391904002132	DNA-binding site [nucleotide binding]; DNA binding site
391904002133	RNA-binding motif; other site
391904002134	Protein of unknown function (DUF935); Region: DUF935; cl19863
391904002135	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
391904002136	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
391904002137	Ligand Binding Site [chemical binding]; other site
391904002138	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
391904002139	Ligand Binding Site [chemical binding]; other site
391904002140	Clp protease ATP binding subunit; Region: clpC; CHL00095
391904002141	Clp amino terminal domain; Region: Clp_N; pfam02861
391904002142	Clp amino terminal domain; Region: Clp_N; pfam02861
391904002143	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904002144	Walker A motif; other site
391904002145	ATP binding site [chemical binding]; other site
391904002146	Walker B motif; other site
391904002147	arginine finger; other site
391904002148	UvrB/uvrC motif; Region: UVR; pfam02151
391904002149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904002150	Walker A motif; other site
391904002151	ATP binding site [chemical binding]; other site
391904002152	Walker B motif; other site
391904002153	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
391904002154	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
391904002155	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
391904002156	active site
391904002157	metal binding site [ion binding]; metal-binding site
391904002158	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
391904002159	Predicted coiled-coil domain-containing protein (DUF2360); Region: DUF2360; pfam10152
391904002160	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
391904002161	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
391904002162	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
391904002163	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
391904002164	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
391904002165	dimer interface [polypeptide binding]; other site
391904002166	motif 1; other site
391904002167	active site
391904002168	motif 2; other site
391904002169	motif 3; other site
391904002170	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
391904002171	anticodon binding site; other site
391904002172	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
391904002173	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
391904002174	dimer interface [polypeptide binding]; other site
391904002175	anticodon binding site; other site
391904002176	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
391904002177	homodimer interface [polypeptide binding]; other site
391904002178	motif 1; other site
391904002179	active site
391904002180	motif 2; other site
391904002181	GAD domain; Region: GAD; pfam02938
391904002182	motif 3; other site
391904002183	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
391904002184	putative active site [active]
391904002185	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391904002186	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
391904002187	Walker A/P-loop; other site
391904002188	ATP binding site [chemical binding]; other site
391904002189	Q-loop/lid; other site
391904002190	ABC transporter signature motif; other site
391904002191	Walker B; other site
391904002192	D-loop; other site
391904002193	H-loop/switch region; other site
391904002194	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904002195	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391904002196	substrate binding pocket [chemical binding]; other site
391904002197	membrane-bound complex binding site; other site
391904002198	hinge residues; other site
391904002199	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
391904002200	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002201	dimer interface [polypeptide binding]; other site
391904002202	conserved gate region; other site
391904002203	putative PBP binding loops; other site
391904002204	ABC-ATPase subunit interface; other site
391904002205	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
391904002206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002207	dimer interface [polypeptide binding]; other site
391904002208	conserved gate region; other site
391904002209	putative PBP binding loops; other site
391904002210	ABC-ATPase subunit interface; other site
391904002211	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
391904002212	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
391904002213	active site
391904002214	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
391904002215	DEAD-like helicases superfamily; Region: DEXDc; smart00487
391904002216	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904002217	ATP binding site [chemical binding]; other site
391904002218	putative Mg++ binding site [ion binding]; other site
391904002219	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904002220	nucleotide binding region [chemical binding]; other site
391904002221	ATP-binding site [chemical binding]; other site
391904002222	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
391904002223	recombination factor protein RarA; Reviewed; Region: PRK13342
391904002224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904002225	Walker A motif; other site
391904002226	ATP binding site [chemical binding]; other site
391904002227	Walker B motif; other site
391904002228	arginine finger; other site
391904002229	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
391904002230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904002231	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904002232	putative substrate translocation pore; other site
391904002233	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
391904002234	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
391904002235	NAD binding site [chemical binding]; other site
391904002236	ligand binding site [chemical binding]; other site
391904002237	catalytic site [active]
391904002238	TM2 domain; Region: TM2; pfam05154
391904002239	Membrane protein of unknown function; Region: DUF360; pfam04020
391904002240	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
391904002241	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
391904002242	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
391904002243	Walker A/P-loop; other site
391904002244	ATP binding site [chemical binding]; other site
391904002245	Q-loop/lid; other site
391904002246	ABC transporter signature motif; other site
391904002247	Walker B; other site
391904002248	D-loop; other site
391904002249	H-loop/switch region; other site
391904002250	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
391904002251	Walker A/P-loop; other site
391904002252	ATP binding site [chemical binding]; other site
391904002253	Q-loop/lid; other site
391904002254	ABC transporter signature motif; other site
391904002255	Walker B; other site
391904002256	D-loop; other site
391904002257	H-loop/switch region; other site
391904002258	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
391904002259	Predicted membrane protein [Function unknown]; Region: COG3601
391904002260	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391904002261	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
391904002262	Probable Catalytic site; other site
391904002263	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904002264	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904002265	nucleotide binding site [chemical binding]; other site
391904002266	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904002267	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904002268	homodimer interface [polypeptide binding]; other site
391904002269	catalytic residue [active]
391904002270	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904002271	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
391904002272	Walker A/P-loop; other site
391904002273	ATP binding site [chemical binding]; other site
391904002274	ABC transporter signature motif; other site
391904002275	Walker B; other site
391904002276	D-loop; other site
391904002277	H-loop/switch region; other site
391904002278	TPR repeat; Region: TPR_11; pfam13414
391904002279	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391904002280	binding surface
391904002281	TPR motif; other site
391904002282	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
391904002283	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
391904002284	nucleotide binding pocket [chemical binding]; other site
391904002285	K-X-D-G motif; other site
391904002286	catalytic site [active]
391904002287	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
391904002288	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
391904002289	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
391904002290	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
391904002291	Dimer interface [polypeptide binding]; other site
391904002292	Domain of unknown function DUF59; Region: DUF59; cl00941
391904002293	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
391904002294	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
391904002295	Walker A motif; other site
391904002296	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
391904002297	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
391904002298	putative active site [active]
391904002299	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
391904002300	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904002301	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904002302	Walker A/P-loop; other site
391904002303	ATP binding site [chemical binding]; other site
391904002304	Q-loop/lid; other site
391904002305	ABC transporter signature motif; other site
391904002306	Walker B; other site
391904002307	D-loop; other site
391904002308	H-loop/switch region; other site
391904002309	elongation factor P; Validated; Region: PRK00529
391904002310	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
391904002311	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
391904002312	RNA binding site [nucleotide binding]; other site
391904002313	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
391904002314	RNA binding site [nucleotide binding]; other site
391904002315	transcription antitermination factor NusB; Region: nusB; TIGR01951
391904002316	putative RNA binding site [nucleotide binding]; other site
391904002317	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
391904002318	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
391904002319	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
391904002320	catalytic site [active]
391904002321	subunit interface [polypeptide binding]; other site
391904002322	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
391904002323	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
391904002324	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391904002325	Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787
391904002326	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
391904002327	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391904002328	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
391904002329	IMP binding site; other site
391904002330	dimer interface [polypeptide binding]; other site
391904002331	interdomain contacts; other site
391904002332	partial ornithine binding site; other site
391904002333	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
391904002334	active site
391904002335	dimer interface [polypeptide binding]; other site
391904002336	Guanylate kinase; Region: Guanylate_kin; pfam00625
391904002337	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
391904002338	catalytic site [active]
391904002339	G-X2-G-X-G-K; other site
391904002340	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
391904002341	active site
391904002342	catalytic site [active]
391904002343	substrate binding site [chemical binding]; other site
391904002344	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
391904002345	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
391904002346	G1 box; other site
391904002347	putative GEF interaction site [polypeptide binding]; other site
391904002348	GTP/Mg2+ binding site [chemical binding]; other site
391904002349	Switch I region; other site
391904002350	G2 box; other site
391904002351	G3 box; other site
391904002352	Switch II region; other site
391904002353	G4 box; other site
391904002354	G5 box; other site
391904002355	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
391904002356	Elongation Factor G, domain II; Region: EFG_II; pfam14492
391904002357	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
391904002358	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
391904002359	Predicted esterase [General function prediction only]; Region: COG0400
391904002360	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
391904002361	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
391904002362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002363	dimer interface [polypeptide binding]; other site
391904002364	conserved gate region; other site
391904002365	putative PBP binding loops; other site
391904002366	ABC-ATPase subunit interface; other site
391904002367	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
391904002368	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002369	dimer interface [polypeptide binding]; other site
391904002370	conserved gate region; other site
391904002371	putative PBP binding loops; other site
391904002372	ABC-ATPase subunit interface; other site
391904002373	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
391904002374	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391904002375	Walker A/P-loop; other site
391904002376	ATP binding site [chemical binding]; other site
391904002377	Q-loop/lid; other site
391904002378	ABC transporter signature motif; other site
391904002379	Walker B; other site
391904002380	D-loop; other site
391904002381	H-loop/switch region; other site
391904002382	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
391904002383	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904002384	substrate binding pocket [chemical binding]; other site
391904002385	membrane-bound complex binding site; other site
391904002386	hinge residues; other site
391904002387	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
391904002388	homodimer interface [polypeptide binding]; other site
391904002389	substrate-cofactor binding pocket; other site
391904002390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904002391	catalytic residue [active]
391904002392	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
391904002393	catalytic residues [active]
391904002394	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
391904002395	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
391904002396	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
391904002397	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
391904002398	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
391904002399	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904002400	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
391904002401	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
391904002402	TM-ABC transporter signature motif; other site
391904002403	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
391904002404	TM-ABC transporter signature motif; other site
391904002405	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
391904002406	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
391904002407	Walker A/P-loop; other site
391904002408	ATP binding site [chemical binding]; other site
391904002409	Q-loop/lid; other site
391904002410	ABC transporter signature motif; other site
391904002411	Walker B; other site
391904002412	D-loop; other site
391904002413	H-loop/switch region; other site
391904002414	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
391904002415	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
391904002416	Walker A/P-loop; other site
391904002417	ATP binding site [chemical binding]; other site
391904002418	Q-loop/lid; other site
391904002419	ABC transporter signature motif; other site
391904002420	Walker B; other site
391904002421	D-loop; other site
391904002422	H-loop/switch region; other site
391904002423	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
391904002424	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
391904002425	metal binding site [ion binding]; metal-binding site
391904002426	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
391904002427	homodimer interface [polypeptide binding]; other site
391904002428	substrate-cofactor binding pocket; other site
391904002429	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904002430	catalytic residue [active]
391904002431	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
391904002432	catalytic residues [active]
391904002433	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391904002434	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904002435	Walker A/P-loop; other site
391904002436	ATP binding site [chemical binding]; other site
391904002437	Q-loop/lid; other site
391904002438	ABC transporter signature motif; other site
391904002439	Walker B; other site
391904002440	D-loop; other site
391904002441	H-loop/switch region; other site
391904002442	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904002443	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391904002444	substrate binding pocket [chemical binding]; other site
391904002445	membrane-bound complex binding site; other site
391904002446	hinge residues; other site
391904002447	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
391904002448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002449	dimer interface [polypeptide binding]; other site
391904002450	conserved gate region; other site
391904002451	putative PBP binding loops; other site
391904002452	ABC-ATPase subunit interface; other site
391904002453	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
391904002454	Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u4; cd03407
391904002455	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904002456	Integrase core domain; Region: rve; pfam00665
391904002457	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904002458	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904002459	Walker A/P-loop; other site
391904002460	ATP binding site [chemical binding]; other site
391904002461	Q-loop/lid; other site
391904002462	ABC transporter signature motif; other site
391904002463	Walker B; other site
391904002464	D-loop; other site
391904002465	H-loop/switch region; other site
391904002466	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
391904002467	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
391904002468	active site
391904002469	nucleophile elbow; other site
391904002470	glutamate racemase; Provisional; Region: PRK00865
391904002471	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
391904002472	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
391904002473	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
391904002474	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
391904002475	putative active site [active]
391904002476	redox center [active]
391904002477	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
391904002478	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
391904002479	active site
391904002480	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
391904002481	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
391904002482	substrate binding site [chemical binding]; other site
391904002483	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
391904002484	Part of AAA domain; Region: AAA_19; pfam13245
391904002485	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
391904002486	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
391904002487	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
391904002488	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
391904002489	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
391904002490	DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543
391904002491	DivIVA domain; Region: DivI1A_domain; TIGR03544
391904002492	DivIVA domain; Region: DivI1A_domain; TIGR03544
391904002493	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
391904002494	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
391904002495	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
391904002496	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
391904002497	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
391904002498	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
391904002499	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
391904002500	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391904002501	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
391904002502	Recombination protein O N terminal; Region: RecO_N; pfam11967
391904002503	Recombination protein O C terminal; Region: RecO_C; pfam02565
391904002504	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
391904002505	active site
391904002506	dimer interface [polypeptide binding]; other site
391904002507	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
391904002508	active site
391904002509	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
391904002510	NMT1/THI5 like; Region: NMT1; pfam09084
391904002511	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
391904002512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002513	dimer interface [polypeptide binding]; other site
391904002514	conserved gate region; other site
391904002515	putative PBP binding loops; other site
391904002516	ABC-ATPase subunit interface; other site
391904002517	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
391904002518	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
391904002519	substrate binding [chemical binding]; other site
391904002520	active site
391904002521	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
391904002522	galactoside permease; Reviewed; Region: lacY; PRK09528
391904002523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904002524	putative substrate translocation pore; other site
391904002525	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904002526	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904002527	DNA binding site [nucleotide binding]
391904002528	domain linker motif; other site
391904002529	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
391904002530	putative dimerization interface [polypeptide binding]; other site
391904002531	putative ligand binding site [chemical binding]; other site
391904002532	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172
391904002533	reactive center loop; other site
391904002534	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904002535	Domain of unknown function DUF77; Region: DUF77; pfam01910
391904002536	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
391904002537	dimer interface [polypeptide binding]; other site
391904002538	substrate binding site [chemical binding]; other site
391904002539	ATP binding site [chemical binding]; other site
391904002540	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904002541	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
391904002542	Walker A motif; other site
391904002543	ATP binding site [chemical binding]; other site
391904002544	Walker B motif; other site
391904002545	arginine finger; other site
391904002546	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
391904002547	thiamine phosphate binding site [chemical binding]; other site
391904002548	active site
391904002549	pyrophosphate binding site [ion binding]; other site
391904002550	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
391904002551	ThiC-associated domain; Region: ThiC-associated; pfam13667
391904002552	ThiC family; Region: ThiC; pfam01964
391904002553	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
391904002554	substrate binding site [chemical binding]; other site
391904002555	multimerization interface [polypeptide binding]; other site
391904002556	ATP binding site [chemical binding]; other site
391904002557	glycyl-tRNA synthetase; Provisional; Region: PRK04173
391904002558	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
391904002559	dimer interface [polypeptide binding]; other site
391904002560	motif 1; other site
391904002561	active site
391904002562	motif 2; other site
391904002563	motif 3; other site
391904002564	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
391904002565	anticodon binding site; other site
391904002566	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
391904002567	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
391904002568	FMN binding site [chemical binding]; other site
391904002569	active site
391904002570	catalytic residues [active]
391904002571	substrate binding site [chemical binding]; other site
391904002572	cell division protein FtsZ; Validated; Region: PRK09330
391904002573	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
391904002574	nucleotide binding site [chemical binding]; other site
391904002575	SulA interaction site; other site
391904002576	Protein of unknown function (DUF552); Region: DUF552; pfam04472
391904002577	YGGT family; Region: YGGT; pfam02325
391904002578	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
391904002579	lipoprotein signal peptidase; Provisional; Region: PRK14771
391904002580	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
391904002581	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391904002582	RNA binding surface [nucleotide binding]; other site
391904002583	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
391904002584	active site
391904002585	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
391904002586	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
391904002587	Predicted transcriptional regulator [Transcription]; Region: COG2378
391904002588	putative DNA binding site [nucleotide binding]; other site
391904002589	putative Zn2+ binding site [ion binding]; other site
391904002590	WYL domain; Region: WYL; pfam13280
391904002591	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
391904002592	DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594
391904002593	active site
391904002594	PHP Thumb interface [polypeptide binding]; other site
391904002595	metal binding site [ion binding]; metal-binding site
391904002596	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; cl19160
391904002597	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
391904002598	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
391904002599	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914
391904002600	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904002601	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904002602	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
391904002603	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
391904002604	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904002605	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
391904002606	Protein of unknown function DUF262; Region: DUF262; pfam03235
391904002607	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
391904002608	Protein of unknown function DUF262; Region: DUF262; pfam03235
391904002609	zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
391904002610	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
391904002611	Transposase; Region: DDE_Tnp_ISL3; pfam01610
391904002612	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
391904002613	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
391904002614	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
391904002615	active site
391904002616	PHP Thumb interface [polypeptide binding]; other site
391904002617	metal binding site [ion binding]; metal-binding site
391904002618	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
391904002619	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
391904002620	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
391904002621	generic binding surface II; other site
391904002622	generic binding surface I; other site
391904002623	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
391904002624	myosin-cross-reactive antigen; Provisional; Region: PRK13977
391904002625	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; pfam06100
391904002626	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904002627	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
391904002628	active site
391904002629	catalytic tetrad [active]
391904002630	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
391904002631	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904002632	nucleotide binding site [chemical binding]; other site
391904002633	acylphosphatase; Provisional; Region: PRK14428
391904002634	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
391904002635	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
391904002636	NAD binding site [chemical binding]; other site
391904002637	dimerization interface [polypeptide binding]; other site
391904002638	product binding site; other site
391904002639	substrate binding site [chemical binding]; other site
391904002640	zinc binding site [ion binding]; other site
391904002641	catalytic residues [active]
391904002642	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
391904002643	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904002644	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904002645	homodimer interface [polypeptide binding]; other site
391904002646	catalytic residue [active]
391904002647	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
391904002648	putative active site pocket [active]
391904002649	4-fold oligomerization interface [polypeptide binding]; other site
391904002650	metal binding residues [ion binding]; metal-binding site
391904002651	3-fold/trimer interface [polypeptide binding]; other site
391904002652	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
391904002653	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
391904002654	putative active site [active]
391904002655	oxyanion strand; other site
391904002656	catalytic triad [active]
391904002657	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
391904002658	catalytic residues [active]
391904002659	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
391904002660	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
391904002661	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
391904002662	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904002663	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
391904002664	putative substrate translocation pore; other site
391904002665	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904002666	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002667	dimer interface [polypeptide binding]; other site
391904002668	conserved gate region; other site
391904002669	putative PBP binding loops; other site
391904002670	ABC-ATPase subunit interface; other site
391904002671	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904002672	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002673	dimer interface [polypeptide binding]; other site
391904002674	conserved gate region; other site
391904002675	putative PBP binding loops; other site
391904002676	ABC-ATPase subunit interface; other site
391904002677	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
391904002678	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
391904002679	peptide binding site [polypeptide binding]; other site
391904002680	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
391904002681	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904002682	Walker A/P-loop; other site
391904002683	ATP binding site [chemical binding]; other site
391904002684	Q-loop/lid; other site
391904002685	ABC transporter signature motif; other site
391904002686	Walker B; other site
391904002687	D-loop; other site
391904002688	H-loop/switch region; other site
391904002689	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904002690	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904002691	Walker A/P-loop; other site
391904002692	ATP binding site [chemical binding]; other site
391904002693	Q-loop/lid; other site
391904002694	ABC transporter signature motif; other site
391904002695	Walker B; other site
391904002696	D-loop; other site
391904002697	H-loop/switch region; other site
391904002698	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904002699	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
391904002700	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904002701	ATP binding site [chemical binding]; other site
391904002702	putative Mg++ binding site [ion binding]; other site
391904002703	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904002704	nucleotide binding region [chemical binding]; other site
391904002705	ATP-binding site [chemical binding]; other site
391904002706	Helicase associated domain (HA2); Region: HA2; pfam04408
391904002707	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
391904002708	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
391904002709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904002710	S-adenosylmethionine binding site [chemical binding]; other site
391904002711	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
391904002712	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
391904002713	HflX GTPase family; Region: HflX; cd01878
391904002714	G1 box; other site
391904002715	GTP/Mg2+ binding site [chemical binding]; other site
391904002716	Switch I region; other site
391904002717	G2 box; other site
391904002718	G3 box; other site
391904002719	Switch II region; other site
391904002720	G4 box; other site
391904002721	G5 box; other site
391904002722	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
391904002723	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
391904002724	NAD binding site [chemical binding]; other site
391904002725	dimer interface [polypeptide binding]; other site
391904002726	substrate binding site [chemical binding]; other site
391904002727	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904002728	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
391904002729	LexA repressor; Validated; Region: PRK00215
391904002730	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
391904002731	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
391904002732	Catalytic site [active]
391904002733	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
391904002734	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
391904002735	ATP cone domain; Region: ATP-cone; pfam03477
391904002736	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
391904002737	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
391904002738	ligand binding site [chemical binding]; other site
391904002739	NAD binding site [chemical binding]; other site
391904002740	tetramer interface [polypeptide binding]; other site
391904002741	catalytic site [active]
391904002742	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
391904002743	L-serine binding site [chemical binding]; other site
391904002744	ACT domain interface; other site
391904002745	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
391904002746	Part of AAA domain; Region: AAA_19; pfam13245
391904002747	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
391904002748	MraZ protein; Region: MraZ; pfam02381
391904002749	cell division protein MraZ; Reviewed; Region: PRK00326
391904002750	MraZ protein; Region: MraZ; pfam02381
391904002751	MraW methylase family; Region: Methyltransf_5; cl17771
391904002752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904002753	S-adenosylmethionine binding site [chemical binding]; other site
391904002754	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
391904002755	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
391904002756	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
391904002757	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
391904002758	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
391904002759	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391904002760	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391904002761	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391904002762	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
391904002763	Mg++ binding site [ion binding]; other site
391904002764	putative catalytic motif [active]
391904002765	putative substrate binding site [chemical binding]; other site
391904002766	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
391904002767	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
391904002768	NAD binding site [chemical binding]; other site
391904002769	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391904002770	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391904002771	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
391904002772	cell division protein FtsW; Region: ftsW; TIGR02614
391904002773	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
391904002774	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
391904002775	active site
391904002776	homodimer interface [polypeptide binding]; other site
391904002777	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
391904002778	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391904002779	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391904002780	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391904002781	cell division protein FtsQ; Provisional; Region: PRK05529
391904002782	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
391904002783	Cell division protein FtsQ; Region: FtsQ; pfam03799
391904002784	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904002785	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391904002786	Walker A/P-loop; other site
391904002787	ATP binding site [chemical binding]; other site
391904002788	Q-loop/lid; other site
391904002789	ABC transporter signature motif; other site
391904002790	Walker B; other site
391904002791	D-loop; other site
391904002792	H-loop/switch region; other site
391904002793	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
391904002794	ABC-2 type transporter; Region: ABC2_membrane; cl17235
391904002795	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904002796	Integrase core domain; Region: rve; pfam00665
391904002797	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
391904002798	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904002799	non-specific DNA binding site [nucleotide binding]; other site
391904002800	sequence-specific DNA binding site [nucleotide binding]; other site
391904002801	salt bridge; other site
391904002802	D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273
391904002803	putative active site [active]
391904002804	dimerization interface [polypeptide binding]; other site
391904002805	putative tRNAtyr binding site [nucleotide binding]; other site
391904002806	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
391904002807	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
391904002808	active site
391904002809	catalytic site [active]
391904002810	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
391904002811	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
391904002812	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
391904002813	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
391904002814	active site
391904002815	catalytic site [active]
391904002816	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
391904002817	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
391904002818	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
391904002819	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
391904002820	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904002821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002822	dimer interface [polypeptide binding]; other site
391904002823	conserved gate region; other site
391904002824	putative PBP binding loops; other site
391904002825	ABC-ATPase subunit interface; other site
391904002826	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904002827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002828	dimer interface [polypeptide binding]; other site
391904002829	conserved gate region; other site
391904002830	putative PBP binding loops; other site
391904002831	ABC-ATPase subunit interface; other site
391904002832	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
391904002833	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904002834	Walker A/P-loop; other site
391904002835	ATP binding site [chemical binding]; other site
391904002836	Q-loop/lid; other site
391904002837	ABC transporter signature motif; other site
391904002838	Walker B; other site
391904002839	D-loop; other site
391904002840	H-loop/switch region; other site
391904002841	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904002842	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904002843	Walker A/P-loop; other site
391904002844	ATP binding site [chemical binding]; other site
391904002845	Q-loop/lid; other site
391904002846	ABC transporter signature motif; other site
391904002847	Walker B; other site
391904002848	D-loop; other site
391904002849	H-loop/switch region; other site
391904002850	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904002851	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904002852	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904002853	DNA binding site [nucleotide binding]
391904002854	domain linker motif; other site
391904002855	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904002856	ligand binding site [chemical binding]; other site
391904002857	dimerization interface [polypeptide binding]; other site
391904002858	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
391904002859	putative active cleft [active]
391904002860	Protein of unknown function (DUF1237); Region: DUF1237; cl19841
391904002861	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
391904002862	putative substrate binding site [chemical binding]; other site
391904002863	putative ATP binding site [chemical binding]; other site
391904002864	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
391904002865	putative DNA binding site [nucleotide binding]; other site
391904002866	Transcriptional regulators [Transcription]; Region: MarR; COG1846
391904002867	putative Zn2+ binding site [ion binding]; other site
391904002868	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904002869	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904002870	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904002871	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904002872	nucleotide binding site [chemical binding]; other site
391904002873	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904002874	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904002875	nucleotide binding site [chemical binding]; other site
391904002876	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
391904002877	active site
391904002878	trimer interface [polypeptide binding]; other site
391904002879	allosteric site; other site
391904002880	active site lid [active]
391904002881	hexamer (dimer of trimers) interface [polypeptide binding]; other site
391904002882	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
391904002883	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
391904002884	active site
391904002885	dimer interface [polypeptide binding]; other site
391904002886	carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850
391904002887	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904002888	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002889	dimer interface [polypeptide binding]; other site
391904002890	conserved gate region; other site
391904002891	putative PBP binding loops; other site
391904002892	ABC-ATPase subunit interface; other site
391904002893	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904002894	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904002895	dimer interface [polypeptide binding]; other site
391904002896	conserved gate region; other site
391904002897	putative PBP binding loops; other site
391904002898	ABC-ATPase subunit interface; other site
391904002899	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
391904002900	nudix motif; other site
391904002901	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
391904002902	proline aminopeptidase P II; Provisional; Region: PRK10879
391904002903	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
391904002904	active site
391904002905	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
391904002906	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
391904002907	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391904002908	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391904002909	Serine-rich region of AP3B1, clathrin-adaptor complex; Region: SEEEED; cl19208
391904002910	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
391904002911	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
391904002912	Walker A/P-loop; other site
391904002913	ATP binding site [chemical binding]; other site
391904002914	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
391904002915	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
391904002916	ABC transporter signature motif; other site
391904002917	Walker B; other site
391904002918	D-loop; other site
391904002919	H-loop/switch region; other site
391904002920	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
391904002921	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
391904002922	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
391904002923	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
391904002924	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
391904002925	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
391904002926	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
391904002927	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
391904002928	DNA binding residues [nucleotide binding]
391904002929	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
391904002930	active site
391904002931	catalytic residues [active]
391904002932	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
391904002933	active site
391904002934	catalytic residues [active]
391904002935	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
391904002936	Fe-S cluster binding site [ion binding]; other site
391904002937	substrate binding site [chemical binding]; other site
391904002938	catalytic site [active]
391904002939	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
391904002940	putative deacylase active site [active]
391904002941	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
391904002942	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
391904002943	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
391904002944	Thiamine pyrophosphokinase; Region: TPK; cd07995
391904002945	active site
391904002946	dimerization interface [polypeptide binding]; other site
391904002947	thiamine binding site [chemical binding]; other site
391904002948	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
391904002949	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
391904002950	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
391904002951	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
391904002952	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
391904002953	23S rRNA binding site [nucleotide binding]; other site
391904002954	L21 binding site [polypeptide binding]; other site
391904002955	L13 binding site [polypeptide binding]; other site
391904002956	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
391904002957	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
391904002958	active site
391904002959	Int/Topo IB signature motif; other site
391904002960	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
391904002961	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
391904002962	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
391904002963	P-loop; other site
391904002964	Magnesium ion binding site [ion binding]; other site
391904002965	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
391904002966	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
391904002967	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
391904002968	nudix motif; other site
391904002969	quinolinate synthetase; Provisional; Region: PRK09375
391904002970	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
391904002971	L-aspartate oxidase; Provisional; Region: PRK06175
391904002972	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
391904002973	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543
391904002974	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
391904002975	dimerization interface [polypeptide binding]; other site
391904002976	active site
391904002977	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
391904002978	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904002979	catalytic residue [active]
391904002980	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
391904002981	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
391904002982	G1 box; other site
391904002983	putative GEF interaction site [polypeptide binding]; other site
391904002984	GTP/Mg2+ binding site [chemical binding]; other site
391904002985	Switch I region; other site
391904002986	G2 box; other site
391904002987	G3 box; other site
391904002988	Switch II region; other site
391904002989	G4 box; other site
391904002990	G5 box; other site
391904002991	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
391904002992	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
391904002993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904002994	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904002995	putative substrate translocation pore; other site
391904002996	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904002997	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
391904002998	Prephenate dehydratase; Region: PDT; pfam00800
391904002999	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
391904003000	putative L-Phe binding site [chemical binding]; other site
391904003001	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
391904003002	prephenate dehydrogenase; Validated; Region: PRK08507
391904003003	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
391904003004	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904003005	active site
391904003006	DNA binding site [nucleotide binding]
391904003007	Int/Topo IB signature motif; other site
391904003008	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
391904003009	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
391904003010	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904003011	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904003012	dimer interface [polypeptide binding]; other site
391904003013	conserved gate region; other site
391904003014	putative PBP binding loops; other site
391904003015	ABC-ATPase subunit interface; other site
391904003016	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
391904003017	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904003018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904003019	dimer interface [polypeptide binding]; other site
391904003020	conserved gate region; other site
391904003021	putative PBP binding loops; other site
391904003022	ABC-ATPase subunit interface; other site
391904003023	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
391904003024	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904003025	Walker A/P-loop; other site
391904003026	ATP binding site [chemical binding]; other site
391904003027	Q-loop/lid; other site
391904003028	ABC transporter signature motif; other site
391904003029	Walker B; other site
391904003030	D-loop; other site
391904003031	H-loop/switch region; other site
391904003032	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904003033	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904003034	Walker A/P-loop; other site
391904003035	ATP binding site [chemical binding]; other site
391904003036	Q-loop/lid; other site
391904003037	ABC transporter signature motif; other site
391904003038	Walker B; other site
391904003039	D-loop; other site
391904003040	H-loop/switch region; other site
391904003041	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904003042	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
391904003043	putative active site [active]
391904003044	putative catalytic site [active]
391904003045	putative DNA binding site [nucleotide binding]; other site
391904003046	putative phosphate binding site [ion binding]; other site
391904003047	metal binding site A [ion binding]; metal-binding site
391904003048	putative AP binding site [nucleotide binding]; other site
391904003049	putative metal binding site B [ion binding]; other site
391904003050	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
391904003051	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
391904003052	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
391904003053	TRAM domain; Region: TRAM; cl01282
391904003054	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904003055	S-adenosylmethionine binding site [chemical binding]; other site
391904003056	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904003057	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
391904003058	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
391904003059	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904003060	motif II; other site
391904003061	Acyltransferase family; Region: Acyl_transf_3; cl19154
391904003062	aconitate hydratase; Validated; Region: PRK09277
391904003063	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
391904003064	substrate binding site [chemical binding]; other site
391904003065	ligand binding site [chemical binding]; other site
391904003066	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
391904003067	substrate binding site [chemical binding]; other site
391904003068	RelB antitoxin; Region: RelB; cl01171
391904003069	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
391904003070	putative active site [active]
391904003071	Protein of unknown function DUF262; Region: DUF262; pfam03235
391904003072	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
391904003073	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
391904003074	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904003075	Coenzyme A binding pocket [chemical binding]; other site
391904003076	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
391904003077	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
391904003078	EamA-like transporter family; Region: EamA; pfam00892
391904003079	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
391904003080	synthetase active site [active]
391904003081	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391904003082	NTP binding site [chemical binding]; other site
391904003083	metal binding site [ion binding]; metal-binding site
391904003084	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
391904003085	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
391904003086	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391904003087	FeS/SAM binding site; other site
391904003088	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
391904003089	Fic/DOC family; Region: Fic; cl00960
391904003090	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
391904003091	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
391904003092	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
391904003093	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
391904003094	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
391904003095	Competence-damaged protein; Region: CinA; pfam02464
391904003096	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904003097	sequence-specific DNA binding site [nucleotide binding]; other site
391904003098	salt bridge; other site
391904003099	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
391904003100	recombinase A; Provisional; Region: recA; PRK09354
391904003101	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
391904003102	hexamer interface [polypeptide binding]; other site
391904003103	Walker A motif; other site
391904003104	ATP binding site [chemical binding]; other site
391904003105	Walker B motif; other site
391904003106	recombination regulator RecX; Reviewed; Region: recX; PRK00117
391904003107	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
391904003108	30S subunit binding site; other site
391904003109	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
391904003110	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904003111	ATP binding site [chemical binding]; other site
391904003112	putative Mg++ binding site [ion binding]; other site
391904003113	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
391904003114	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
391904003115	SEC-C motif; Region: SEC-C; pfam02810
391904003116	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
391904003117	active site
391904003118	catalytic triad [active]
391904003119	oxyanion hole [active]
391904003120	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
391904003121	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
391904003122	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
391904003123	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
391904003124	putative acyl-acceptor binding pocket; other site
391904003125	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
391904003126	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
391904003127	active site
391904003128	ATP binding site [chemical binding]; other site
391904003129	substrate binding site [chemical binding]; other site
391904003130	activation loop (A-loop); other site
391904003131	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
391904003132	PASTA domain; Region: PASTA; pfam03793
391904003133	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
391904003134	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
391904003135	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
391904003136	substrate binding pocket [chemical binding]; other site
391904003137	chain length determination region; other site
391904003138	substrate-Mg2+ binding site; other site
391904003139	catalytic residues [active]
391904003140	aspartate-rich region 1; other site
391904003141	active site lid residues [active]
391904003142	aspartate-rich region 2; other site
391904003143	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
391904003144	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
391904003145	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
391904003146	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
391904003147	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
391904003148	DNA binding residues [nucleotide binding]
391904003149	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
391904003150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904003151	ATP binding site [chemical binding]; other site
391904003152	Mg2+ binding site [ion binding]; other site
391904003153	G-X-G motif; other site
391904003154	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
391904003155	anchoring element; other site
391904003156	dimer interface [polypeptide binding]; other site
391904003157	ATP binding site [chemical binding]; other site
391904003158	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
391904003159	active site
391904003160	metal binding site [ion binding]; metal-binding site
391904003161	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
391904003162	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904003163	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904003164	putative substrate translocation pore; other site
391904003165	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
391904003166	substrate binding site [chemical binding]; other site
391904003167	dimer interface [polypeptide binding]; other site
391904003168	ATP binding site [chemical binding]; other site
391904003169	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904003170	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
391904003171	ATP binding site [chemical binding]; other site
391904003172	putative Mg++ binding site [ion binding]; other site
391904003173	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904003174	nucleotide binding region [chemical binding]; other site
391904003175	ATP-binding site [chemical binding]; other site
391904003176	DEAD/H associated; Region: DEAD_assoc; pfam08494
391904003177	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904003178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
391904003179	phosphorylation site [posttranslational modification]
391904003180	intermolecular recognition site; other site
391904003181	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
391904003182	DNA binding site [nucleotide binding]
391904003183	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
391904003184	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
391904003185	CAP-like domain; other site
391904003186	active site
391904003187	primary dimer interface [polypeptide binding]; other site
391904003188	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
391904003189	Sulfatase; Region: Sulfatase; cl19157
391904003190	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
391904003191	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
391904003192	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
391904003193	trimer interface [polypeptide binding]; other site
391904003194	active site
391904003195	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
391904003196	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
391904003197	Zn2+ binding site [ion binding]; other site
391904003198	Mg2+ binding site [ion binding]; other site
391904003199	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
391904003200	synthetase active site [active]
391904003201	NTP binding site [chemical binding]; other site
391904003202	metal binding site [ion binding]; metal-binding site
391904003203	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
391904003204	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
391904003205	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
391904003206	active site
391904003207	HipA-like C-terminal domain; Region: HipA_C; pfam07804
391904003208	Fic family protein [Function unknown]; Region: COG3177
391904003209	Fic/DOC family; Region: Fic; pfam02661
391904003210	Integrase core domain; Region: rve; pfam00665
391904003211	Integrase core domain; Region: rve_3; cl15866
391904003212	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904003213	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904003214	putative substrate translocation pore; other site
391904003215	Transposase, Mutator family; Region: Transposase_mut; cl19537
391904003216	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
391904003217	Fic/DOC family; Region: Fic; cl00960
391904003218	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
391904003219	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904003220	active site
391904003221	Int/Topo IB signature motif; other site
391904003222	DNA binding site [nucleotide binding]
391904003223	Abi-like protein; Region: Abi_2; cl01988
391904003224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904003225	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904003226	putative substrate translocation pore; other site
391904003227	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
391904003228	Reprolysin family propeptide; Region: Pep_M12B_propep; pfam01562
391904003229	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904003230	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904003231	Integrase core domain; Region: rve; pfam00665
391904003232	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904003233	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
391904003234	Walker A/P-loop; other site
391904003235	ATP binding site [chemical binding]; other site
391904003236	Q-loop/lid; other site
391904003237	ABC transporter signature motif; other site
391904003238	Walker B; other site
391904003239	D-loop; other site
391904003240	H-loop/switch region; other site
391904003241	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
391904003242	MULE transposase domain; Region: MULE; pfam10551
391904003243	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
391904003244	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904003245	Walker A/P-loop; other site
391904003246	ATP binding site [chemical binding]; other site
391904003247	Q-loop/lid; other site
391904003248	ABC transporter signature motif; other site
391904003249	Walker B; other site
391904003250	D-loop; other site
391904003251	H-loop/switch region; other site
391904003252	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
391904003253	lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733
391904003254	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904003255	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904003256	active site
391904003257	phosphorylation site [posttranslational modification]
391904003258	intermolecular recognition site; other site
391904003259	dimerization interface [polypeptide binding]; other site
391904003260	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391904003261	DNA binding site [nucleotide binding]
391904003262	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391904003263	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391904003264	dimer interface [polypeptide binding]; other site
391904003265	phosphorylation site [posttranslational modification]
391904003266	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904003267	ATP binding site [chemical binding]; other site
391904003268	Mg2+ binding site [ion binding]; other site
391904003269	G-X-G motif; other site
391904003270	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
391904003271	EamA-like transporter family; Region: EamA; pfam00892
391904003272	EamA-like transporter family; Region: EamA; pfam00892
391904003273	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
391904003274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
391904003275	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904003276	catalytic core [active]
391904003277	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
391904003278	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
391904003279	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
391904003280	Cl binding site [ion binding]; other site
391904003281	oligomer interface [polypeptide binding]; other site
391904003282	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
391904003283	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904003284	substrate binding pocket [chemical binding]; other site
391904003285	membrane-bound complex binding site; other site
391904003286	hinge residues; other site
391904003287	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
391904003288	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391904003289	active site
391904003290	HIGH motif; other site
391904003291	nucleotide binding site [chemical binding]; other site
391904003292	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
391904003293	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
391904003294	active site
391904003295	KMSKS motif; other site
391904003296	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
391904003297	tRNA binding surface [nucleotide binding]; other site
391904003298	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
391904003299	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
391904003300	Competence protein; Region: Competence; pfam03772
391904003301	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
391904003302	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
391904003303	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912
391904003304	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
391904003305	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
391904003306	Glycoprotease family; Region: Peptidase_M22; pfam00814
391904003307	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
391904003308	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904003309	Coenzyme A binding pocket [chemical binding]; other site
391904003310	UGMP family protein; Validated; Region: PRK09604
391904003311	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
391904003312	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904003313	AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271
391904003314	Putative amidase domain; Region: Amidase_6; pfam12671
391904003315	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904003316	Integrase core domain; Region: rve; pfam00665
391904003317	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904003318	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904003319	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904003320	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904003321	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904003322	non-specific DNA binding site [nucleotide binding]; other site
391904003323	salt bridge; other site
391904003324	sequence-specific DNA binding site [nucleotide binding]; other site
391904003325	SdpI/YhfL protein family; Region: SdpI; pfam13630
391904003326	peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078
391904003327	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
391904003328	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904003329	S-adenosylmethionine binding site [chemical binding]; other site
391904003330	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904003331	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904003332	Walker A/P-loop; other site
391904003333	ATP binding site [chemical binding]; other site
391904003334	Q-loop/lid; other site
391904003335	ABC transporter signature motif; other site
391904003336	Walker B; other site
391904003337	D-loop; other site
391904003338	H-loop/switch region; other site
391904003339	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
391904003340	Fic family protein [Function unknown]; Region: COG3177
391904003341	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904003342	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904003343	Integrase core domain; Region: rve; pfam00665
391904003344	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904003345	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904003346	Walker A/P-loop; other site
391904003347	ATP binding site [chemical binding]; other site
391904003348	Q-loop/lid; other site
391904003349	ABC transporter signature motif; other site
391904003350	Walker B; other site
391904003351	D-loop; other site
391904003352	H-loop/switch region; other site
391904003353	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
391904003354	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
391904003355	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904003356	Histidine kinase; Region: HisKA_3; pfam07730
391904003357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904003358	ATP binding site [chemical binding]; other site
391904003359	Mg2+ binding site [ion binding]; other site
391904003360	G-X-G motif; other site
391904003361	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904003362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904003363	active site
391904003364	phosphorylation site [posttranslational modification]
391904003365	intermolecular recognition site; other site
391904003366	dimerization interface [polypeptide binding]; other site
391904003367	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
391904003368	DNA binding residues [nucleotide binding]
391904003369	dimerization interface [polypeptide binding]; other site
391904003370	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
391904003371	Peptidase family M23; Region: Peptidase_M23; pfam01551
391904003372	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904003373	isocitrate dehydrogenase; Validated; Region: PRK08299
391904003374	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
391904003375	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
391904003376	active site
391904003377	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
391904003378	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
391904003379	acyl-activating enzyme (AAE) consensus motif; other site
391904003380	putative AMP binding site [chemical binding]; other site
391904003381	putative active site [active]
391904003382	putative CoA binding site [chemical binding]; other site
391904003383	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
391904003384	active site
391904003385	catalytic residues [active]
391904003386	metal binding site [ion binding]; metal-binding site
391904003387	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
391904003388	rRNA interaction site [nucleotide binding]; other site
391904003389	S8 interaction site; other site
391904003390	putative laminin-1 binding site; other site
391904003391	elongation factor Ts; Provisional; Region: tsf; PRK09377
391904003392	UBA/TS-N domain; Region: UBA; pfam00627
391904003393	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
391904003394	putative nucleotide binding site [chemical binding]; other site
391904003395	uridine monophosphate binding site [chemical binding]; other site
391904003396	homohexameric interface [polypeptide binding]; other site
391904003397	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
391904003398	hinge region; other site
391904003399	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
391904003400	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
391904003401	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391904003402	FeS/SAM binding site; other site
391904003403	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
391904003404	conserved cys residue [active]
391904003405	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
391904003406	substrate binding site [chemical binding]; other site
391904003407	glutamase interaction surface [polypeptide binding]; other site
391904003408	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
391904003409	anthranilate synthase component I; Provisional; Region: PRK13571
391904003410	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
391904003411	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
391904003412	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
391904003413	putative substrate binding pocket [chemical binding]; other site
391904003414	AC domain interface; other site
391904003415	catalytic triad [active]
391904003416	AB domain interface; other site
391904003417	interchain disulfide; other site
391904003418	Protein of unknown function (DUF979); Region: DUF979; cl19737
391904003419	Protein of unknown function (DUF969); Region: DUF969; cl01573
391904003420	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
391904003421	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904003422	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904003423	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
391904003424	classical (c) SDRs; Region: SDR_c; cd05233
391904003425	NAD(P) binding site [chemical binding]; other site
391904003426	active site
391904003427	Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; Region: MMP_TTHA0227_like; cl01577
391904003428	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
391904003429	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
391904003430	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904003431	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904003432	Walker A/P-loop; other site
391904003433	ATP binding site [chemical binding]; other site
391904003434	Q-loop/lid; other site
391904003435	ABC transporter signature motif; other site
391904003436	Walker B; other site
391904003437	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
391904003438	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
391904003439	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
391904003440	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
391904003441	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
391904003442	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
391904003443	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
391904003444	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
391904003445	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
391904003446	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
391904003447	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
391904003448	GIY-YIG motif/motif A; other site
391904003449	active site
391904003450	catalytic site [active]
391904003451	putative DNA binding site [nucleotide binding]; other site
391904003452	metal binding site [ion binding]; metal-binding site
391904003453	UvrB/uvrC motif; Region: UVR; pfam02151
391904003454	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
391904003455	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
391904003456	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
391904003457	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
391904003458	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
391904003459	shikimate binding site; other site
391904003460	NAD(P) binding site [chemical binding]; other site
391904003461	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
391904003462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
391904003463	WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298
391904003464	WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527
391904003465	WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650
391904003466	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
391904003467	substrate binding site [chemical binding]; other site
391904003468	hinge regions; other site
391904003469	ADP binding site [chemical binding]; other site
391904003470	catalytic site [active]
391904003471	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
391904003472	substrate binding site [chemical binding]; other site
391904003473	dimer interface [polypeptide binding]; other site
391904003474	catalytic triad [active]
391904003475	Preprotein translocase SecG subunit; Region: SecG; pfam03840
391904003476	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
391904003477	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904003478	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
391904003479	NAD binding site [chemical binding]; other site
391904003480	dimer interface [polypeptide binding]; other site
391904003481	substrate binding site [chemical binding]; other site
391904003482	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
391904003483	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904003484	active site
391904003485	motif I; other site
391904003486	motif II; other site
391904003487	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
391904003488	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
391904003489	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904003490	salt bridge; other site
391904003491	non-specific DNA binding site [nucleotide binding]; other site
391904003492	sequence-specific DNA binding site [nucleotide binding]; other site
391904003493	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904003494	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904003495	homodimer interface [polypeptide binding]; other site
391904003496	catalytic residue [active]
391904003497	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
391904003498	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
391904003499	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
391904003500	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
391904003501	putative active site [active]
391904003502	catalytic residue [active]
391904003503	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
391904003504	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
391904003505	TPP-binding site [chemical binding]; other site
391904003506	dimer interface [polypeptide binding]; other site
391904003507	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
391904003508	PYR/PP interface [polypeptide binding]; other site
391904003509	dimer interface [polypeptide binding]; other site
391904003510	TPP binding site [chemical binding]; other site
391904003511	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
391904003512	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
391904003513	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
391904003514	HrcA protein C terminal domain; Region: HrcA; pfam01628
391904003515	chaperone protein DnaJ; Provisional; Region: PRK14278
391904003516	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
391904003517	HSP70 interaction site [polypeptide binding]; other site
391904003518	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
391904003519	Zn binding sites [ion binding]; other site
391904003520	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
391904003521	dimer interface [polypeptide binding]; other site
391904003522	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
391904003523	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
391904003524	active site
391904003525	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
391904003526	Laminin Domain II; Region: Laminin_II; pfam06009
391904003527	Phage tail protein; Region: Sipho_tail; cl17486
391904003528	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
391904003529	Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355
391904003530	Phage capsid family; Region: Phage_capsid; pfam05065
391904003531	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
391904003532	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; cl19531
391904003533	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
391904003534	Phage Terminase; Region: Terminase_1; cl19862
391904003535	RNAse P Rpr2/Rpp21/SNM1 subunit domain; Region: Rpr2; cl00887
391904003536	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
391904003537	polymerase nucleotide-binding site; other site
391904003538	DNA-binding residues [nucleotide binding]; DNA binding site
391904003539	nucleotide binding site [chemical binding]; other site
391904003540	primase nucleotide-binding site [nucleotide binding]; other site
391904003541	AAA domain; Region: AAA_25; pfam13481
391904003542	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
391904003543	Walker A motif; other site
391904003544	ATP binding site [chemical binding]; other site
391904003545	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
391904003546	G1 box; other site
391904003547	GTP/Mg2+ binding site [chemical binding]; other site
391904003548	G2 box; other site
391904003549	Switch I region; other site
391904003550	G3 box; other site
391904003551	Switch II region; other site
391904003552	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
391904003553	Helix-turn-helix domain; Region: HTH_17; pfam12728
391904003554	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
391904003555	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
391904003556	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
391904003557	Domain of unknown function (DUF955); Region: DUF955; cl01076
391904003558	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
391904003559	cofactor binding site; other site
391904003560	DNA binding site [nucleotide binding]
391904003561	substrate interaction site [chemical binding]; other site
391904003562	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904003563	ATP binding site [chemical binding]; other site
391904003564	Mg2+ binding site [ion binding]; other site
391904003565	G-X-G motif; other site
391904003566	AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657
391904003567	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659
391904003568	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
391904003569	Phage integrase family; Region: Phage_integrase; pfam00589
391904003570	active site
391904003571	DNA binding site [nucleotide binding]
391904003572	Int/Topo IB signature motif; other site
391904003573	Fructosamine kinase; Region: Fructosamin_kin; cl17579
391904003574	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
391904003575	PAC2 family; Region: PAC2; pfam09754
391904003576	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
391904003577	thiS-thiF/thiG interaction site; other site
391904003578	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
391904003579	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
391904003580	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
391904003581	active site
391904003582	dimer interface [polypeptide binding]; other site
391904003583	motif 1; other site
391904003584	motif 2; other site
391904003585	motif 3; other site
391904003586	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
391904003587	anticodon binding site; other site
391904003588	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
391904003589	nucleotide binding site/active site [active]
391904003590	HIT family signature motif; other site
391904003591	catalytic residue [active]
391904003592	hypothetical protein; Validated; Region: PRK00110
391904003593	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
391904003594	active site
391904003595	putative DNA-binding cleft [nucleotide binding]; other site
391904003596	dimer interface [polypeptide binding]; other site
391904003597	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
391904003598	RuvA N terminal domain; Region: RuvA_N; pfam01330
391904003599	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
391904003600	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
391904003601	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
391904003602	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904003603	Walker A motif; other site
391904003604	ATP binding site [chemical binding]; other site
391904003605	Walker B motif; other site
391904003606	arginine finger; other site
391904003607	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
391904003608	Preprotein translocase subunit; Region: YajC; pfam02699
391904003609	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904003610	active site
391904003611	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
391904003612	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
391904003613	CoA-ligase; Region: Ligase_CoA; pfam00549
391904003614	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
391904003615	CoA binding domain; Region: CoA_binding; pfam02629
391904003616	CoA-ligase; Region: Ligase_CoA; pfam00549
391904003617	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
391904003618	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
391904003619	purine monophosphate binding site [chemical binding]; other site
391904003620	dimer interface [polypeptide binding]; other site
391904003621	putative catalytic residues [active]
391904003622	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
391904003623	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
391904003624	amphipathic channel; other site
391904003625	Asn-Pro-Ala signature motifs; other site
391904003626	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
391904003627	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391904003628	RNA binding surface [nucleotide binding]; other site
391904003629	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
391904003630	active site
391904003631	bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518
391904003632	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
391904003633	CMP-binding site; other site
391904003634	The sites determining sugar specificity; other site
391904003635	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
391904003636	G1 box; other site
391904003637	GTP/Mg2+ binding site [chemical binding]; other site
391904003638	Switch I region; other site
391904003639	G2 box; other site
391904003640	Switch II region; other site
391904003641	G3 box; other site
391904003642	G4 box; other site
391904003643	G5 box; other site
391904003644	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
391904003645	G1 box; other site
391904003646	GTP/Mg2+ binding site [chemical binding]; other site
391904003647	Switch I region; other site
391904003648	G2 box; other site
391904003649	G3 box; other site
391904003650	Switch II region; other site
391904003651	G4 box; other site
391904003652	G5 box; other site
391904003653	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
391904003654	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
391904003655	MULE transposase domain; Region: MULE; pfam10551
391904003656	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391904003657	active site
391904003658	Predicted transcriptional regulator [Transcription]; Region: COG2378
391904003659	WYL domain; Region: WYL; pfam13280
391904003660	DEAD-like helicases superfamily; Region: DEXDc; smart00487
391904003661	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904003662	ATP binding site [chemical binding]; other site
391904003663	putative Mg++ binding site [ion binding]; other site
391904003664	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904003665	nucleotide binding region [chemical binding]; other site
391904003666	ATP-binding site [chemical binding]; other site
391904003667	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
391904003668	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
391904003669	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
391904003670	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904003671	motif II; other site
391904003672	Helix-turn-helix domain; Region: HTH_17; pfam12728
391904003673	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
391904003674	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904003675	ATP binding site [chemical binding]; other site
391904003676	putative Mg++ binding site [ion binding]; other site
391904003677	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904003678	nucleotide binding region [chemical binding]; other site
391904003679	ATP-binding site [chemical binding]; other site
391904003680	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
391904003681	Probable transposase; Region: OrfB_IS605; pfam01385
391904003682	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
391904003683	putative glutathione S-transferase; Provisional; Region: PRK10357
391904003684	large tegument protein UL36; Provisional; Region: PHA03247
391904003685	Fimbrial protein; Region: Fimbrial; cl01416
391904003686	VRR-NUC domain; Region: VRR_NUC; pfam08774
391904003687	Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417
391904003688	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
391904003689	hypothetical protein; Provisional; Region: nrdC.11; PHA02603
391904003690	active site
391904003691	NTP binding site [chemical binding]; other site
391904003692	metal binding triad [ion binding]; metal-binding site
391904003693	Fic/DOC family; Region: Fic; pfam02661
391904003694	Probable transposase; Region: OrfB_IS605; pfam01385
391904003695	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
391904003696	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
391904003697	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
391904003698	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
391904003699	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
391904003700	Surface antigen [General function prediction only]; Region: COG3942
391904003701	CHAP domain; Region: CHAP; pfam05257
391904003702	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
391904003703	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
391904003704	active site
391904003705	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
391904003706	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904003707	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904003708	sequence-specific DNA binding site [nucleotide binding]; other site
391904003709	salt bridge; other site
391904003710	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
391904003711	DNA methylase; Region: N6_N4_Mtase; cl17433
391904003712	APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; Region: APC10-like; cl02148
391904003713	putative ligand binding site [chemical binding]; other site
391904003714	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095
391904003715	cofactor binding site; other site
391904003716	DNA binding site [nucleotide binding]
391904003717	substrate interaction site [chemical binding]; other site
391904003718	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
391904003719	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
391904003720	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
391904003721	catalytic residues [active]
391904003722	catalytic nucleophile [active]
391904003723	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
391904003724	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
391904003725	Probable transposase; Region: OrfB_IS605; pfam01385
391904003726	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
391904003727	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
391904003728	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
391904003729	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904003730	active site
391904003731	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
391904003732	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
391904003733	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
391904003734	active site
391904003735	catalytic site [active]
391904003736	substrate binding site [chemical binding]; other site
391904003737	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904003738	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904003739	non-specific DNA binding site [nucleotide binding]; other site
391904003740	salt bridge; other site
391904003741	sequence-specific DNA binding site [nucleotide binding]; other site
391904003742	PIF1-like helicase; Region: PIF1; pfam05970
391904003743	AAA domain; Region: AAA_30; pfam13604
391904003744	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
391904003745	T surface-antigen of pili; Region: FctA; cl16948
391904003746	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904003747	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904003748	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904003749	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
391904003750	thioester formation/cholesterol transfer; other site
391904003751	Hom_end-associated Hint; Region: Hom_end_hint; pfam05203
391904003752	Homing endonuclease; Region: Hom_end; pfam05204
391904003753	AAA-like domain; Region: AAA_10; pfam12846
391904003754	CHAP domain; Region: CHAP; cl17642
391904003755	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
391904003756	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
391904003757	DNA polymerase III subunit beta; Validated; Region: PRK07761
391904003758	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
391904003759	putative DNA binding surface [nucleotide binding]; other site
391904003760	dimer interface [polypeptide binding]; other site
391904003761	beta-clamp/clamp loader binding surface; other site
391904003762	beta-clamp/translesion DNA polymerase binding surface; other site
391904003763	N-terminal protein-binding module of harmonin and similar domains, also known as HHD (harmonin homology domain); Region: harmonin_N_like; cl11968
391904003764	putative protein binding site [polypeptide binding]; other site
391904003765	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
391904003766	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904003767	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
391904003768	Serine-rich region of AP3B1, clathrin-adaptor complex; Region: SEEEED; cl19208
391904003769	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
391904003770	T surface-antigen of pili; Region: FctA; pfam12892
391904003771	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
391904003772	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
391904003773	T surface-antigen of pili; Region: FctA; pfam12892
391904003774	T surface-antigen of pili; Region: FctA; pfam12892
391904003775	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
391904003776	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
391904003777	nucleotide binding site [chemical binding]; other site
391904003778	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
391904003779	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
391904003780	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
391904003781	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
391904003782	Transcription factor WhiB; Region: Whib; pfam02467
391904003783	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
391904003784	carbon starvation protein A; Provisional; Region: PRK15015
391904003785	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
391904003786	active site
391904003787	catalytic site [active]
391904003788	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
391904003789	active site
391904003790	metal binding site [ion binding]; metal-binding site
391904003791	Multidrug resistance efflux transporter; Region: EmrE; cl19304
391904003792	putative RNA ligase; Region: PHA02142
391904003793	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
391904003794	FemAB family; Region: FemAB; pfam02388
391904003795	Transposase IS200 like; Region: Y1_Tnp; pfam01797
391904003796	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
391904003797	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
391904003798	Probable transposase; Region: OrfB_IS605; pfam01385
391904003799	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
391904003800	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350
391904003801	iron binding site [ion binding]; other site
391904003802	hypothetical protein; Provisional; Region: PRK06148
391904003803	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
391904003804	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
391904003805	Probable transposase; Region: OrfB_IS605; pfam01385
391904003806	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
391904003807	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
391904003808	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
391904003809	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
391904003810	Domain of unknown function (DUF3841); Region: DUF3841; pfam12952
391904003811	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
391904003812	Methyltransferase domain; Region: Methyltransf_26; pfam13659
391904003813	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
391904003814	putative active site [active]
391904003815	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904003816	non-specific DNA binding site [nucleotide binding]; other site
391904003817	salt bridge; other site
391904003818	sequence-specific DNA binding site [nucleotide binding]; other site
391904003819	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
391904003820	OPT oligopeptide transporter protein; Region: OPT; cl14607
391904003821	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
391904003822	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904003823	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
391904003824	active site
391904003825	DNA binding site [nucleotide binding]
391904003826	Int/Topo IB signature motif; other site
391904003827	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659
391904003828	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904003829	active site
391904003830	Int/Topo IB signature motif; other site
391904003831	DNA binding site [nucleotide binding]
391904003832	Probable transposase; Region: OrfB_IS605; pfam01385
391904003833	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
391904003834	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
391904003835	HipA N-terminal domain; Region: Couple_hipA; pfam13657
391904003836	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
391904003837	HipA-like N-terminal domain; Region: HipA_N; pfam07805
391904003838	HipA-like C-terminal domain; Region: HipA_C; pfam07804
391904003839	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904003840	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904003841	Integrase core domain; Region: rve; pfam00665
391904003842	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904003843	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
391904003844	Walker A/P-loop; other site
391904003845	ATP binding site [chemical binding]; other site
391904003846	Q-loop/lid; other site
391904003847	ABC transporter signature motif; other site
391904003848	Walker B; other site
391904003849	D-loop; other site
391904003850	H-loop/switch region; other site
391904003851	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904003852	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904003853	FtsX-like permease family; Region: FtsX; pfam02687
391904003854	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
391904003855	DNA binding residues [nucleotide binding]
391904003856	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
391904003857	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
391904003858	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
391904003859	phosphopeptide binding site; other site
391904003860	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
391904003861	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
391904003862	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
391904003863	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
391904003864	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
391904003865	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
391904003866	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
391904003867	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
391904003868	homodimer interface [polypeptide binding]; other site
391904003869	putative metal binding site [ion binding]; other site
391904003870	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
391904003871	substrate binding site [chemical binding]; other site
391904003872	hexamer interface [polypeptide binding]; other site
391904003873	metal binding site [ion binding]; metal-binding site
391904003874	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
391904003875	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
391904003876	substrate binding site [chemical binding]; other site
391904003877	active site
391904003878	catalytic residues [active]
391904003879	heterodimer interface [polypeptide binding]; other site
391904003880	bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802
391904003881	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
391904003882	active site
391904003883	ribulose/triose binding site [chemical binding]; other site
391904003884	phosphate binding site [ion binding]; other site
391904003885	substrate (anthranilate) binding pocket [chemical binding]; other site
391904003886	product (indole) binding pocket [chemical binding]; other site
391904003887	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
391904003888	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904003889	catalytic residue [active]
391904003890	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
391904003891	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
391904003892	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
391904003893	AP (apurinic/apyrimidinic) site pocket; other site
391904003894	DNA interaction; other site
391904003895	Metal-binding active site; metal-binding site
391904003896	S-methylmethionine transporter; Provisional; Region: PRK11387
391904003897	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
391904003898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904003899	VanZ like family; Region: VanZ; cl01971
391904003900	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
391904003901	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904003902	catalytic residue [active]
391904003903	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
391904003904	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904003905	Coenzyme A binding pocket [chemical binding]; other site
391904003906	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805
391904003907	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
391904003908	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904003909	Coenzyme A binding pocket [chemical binding]; other site
391904003910	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
391904003911	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
391904003912	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478
391904003913	Na binding site [ion binding]; other site
391904003914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904003915	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904003916	putative substrate translocation pore; other site
391904003917	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
391904003918	active site
391904003919	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
391904003920	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
391904003921	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
391904003922	Domain of unknown function (DUF4657); Region: DUF4657; pfam15552
391904003923	Abi-like protein; Region: Abi_2; pfam07751
391904003924	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904003925	Histidine kinase; Region: HisKA_3; pfam07730
391904003926	Outer membrane lipoprotein LolB; Region: LolB; cl19307
391904003927	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
391904003928	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
391904003929	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904003930	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904003931	Walker A/P-loop; other site
391904003932	ATP binding site [chemical binding]; other site
391904003933	Q-loop/lid; other site
391904003934	ABC transporter signature motif; other site
391904003935	Walker B; other site
391904003936	D-loop; other site
391904003937	H-loop/switch region; other site
391904003938	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904003939	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904003940	FtsX-like permease family; Region: FtsX; pfam02687
391904003941	RelB antitoxin; Region: RelB; cl01171
391904003942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
391904003943	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
391904003944	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
391904003945	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
391904003946	DNA binding residues [nucleotide binding]
391904003947	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904003948	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
391904003949	Walker A/P-loop; other site
391904003950	ATP binding site [chemical binding]; other site
391904003951	Q-loop/lid; other site
391904003952	ABC transporter signature motif; other site
391904003953	Walker B; other site
391904003954	D-loop; other site
391904003955	H-loop/switch region; other site
391904003956	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
391904003957	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
391904003958	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904003959	Walker A/P-loop; other site
391904003960	ATP binding site [chemical binding]; other site
391904003961	Q-loop/lid; other site
391904003962	ABC transporter signature motif; other site
391904003963	Walker B; other site
391904003964	D-loop; other site
391904003965	H-loop/switch region; other site
391904003966	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904003967	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904003968	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904003969	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904003970	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904003971	active site
391904003972	phosphorylation site [posttranslational modification]
391904003973	intermolecular recognition site; other site
391904003974	dimerization interface [polypeptide binding]; other site
391904003975	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904003976	DNA binding residues [nucleotide binding]
391904003977	dimerization interface [polypeptide binding]; other site
391904003978	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904003979	Histidine kinase; Region: HisKA_3; pfam07730
391904003980	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
391904003981	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
391904003982	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904003983	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904003984	Walker A/P-loop; other site
391904003985	ATP binding site [chemical binding]; other site
391904003986	Q-loop/lid; other site
391904003987	ABC transporter signature motif; other site
391904003988	Walker B; other site
391904003989	D-loop; other site
391904003990	H-loop/switch region; other site
391904003991	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
391904003992	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
391904003993	DNA binding residues [nucleotide binding]
391904003994	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
391904003995	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
391904003996	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
391904003997	nudix motif; other site
391904003998	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
391904003999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904004000	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904004001	S-methylmethionine transporter; Provisional; Region: PRK11387
391904004002	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
391904004003	Uncharacterized conserved protein [Function unknown]; Region: COG3189
391904004004	Domain of unknown function (DUF1287); Region: DUF1287; cl01519
391904004005	Fic/DOC family; Region: Fic; pfam02661
391904004006	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
391904004007	Uncharacterized conserved protein [Function unknown]; Region: COG3189
391904004008	C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126
391904004009	aspartate aminotransferase; Provisional; Region: PRK06836
391904004010	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904004011	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904004012	homodimer interface [polypeptide binding]; other site
391904004013	catalytic residue [active]
391904004014	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
391904004015	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
391904004016	putative substrate binding site [chemical binding]; other site
391904004017	putative ATP binding site [chemical binding]; other site
391904004018	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
391904004019	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904004020	motif II; other site
391904004021	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391904004022	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391904004023	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
391904004024	dimerization interface [polypeptide binding]; other site
391904004025	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
391904004026	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904004027	active site
391904004028	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
391904004029	heterodimer interface [polypeptide binding]; other site
391904004030	active site
391904004031	FMN binding site [chemical binding]; other site
391904004032	homodimer interface [polypeptide binding]; other site
391904004033	substrate binding site [chemical binding]; other site
391904004034	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
391904004035	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
391904004036	FAD binding pocket [chemical binding]; other site
391904004037	FAD binding motif [chemical binding]; other site
391904004038	phosphate binding motif [ion binding]; other site
391904004039	beta-alpha-beta structure motif; other site
391904004040	NAD binding pocket [chemical binding]; other site
391904004041	Iron coordination center [ion binding]; other site
391904004042	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
391904004043	active site
391904004044	dimer interface [polypeptide binding]; other site
391904004045	dihydroorotase; Validated; Region: pyrC; PRK09357
391904004046	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
391904004047	active site
391904004048	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
391904004049	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
391904004050	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
391904004051	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
391904004052	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
391904004053	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
391904004054	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
391904004055	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
391904004056	metal binding triad; other site
391904004057	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
391904004058	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
391904004059	metal binding triad; other site
391904004060	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627
391904004061	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
391904004062	active site
391904004063	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
391904004064	FAD binding site [chemical binding]; other site
391904004065	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
391904004066	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
391904004067	THF binding site; other site
391904004068	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
391904004069	substrate binding site [chemical binding]; other site
391904004070	THF binding site; other site
391904004071	zinc-binding site [ion binding]; other site
391904004072	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904004073	catalytic core [active]
391904004074	tRNA methyltransferase complex GCD14 subunit N-term; Region: GCD14_N; pfam14801
391904004075	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
391904004076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904004077	S-adenosylmethionine binding site [chemical binding]; other site
391904004078	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
391904004079	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
391904004080	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
391904004081	active site
391904004082	metal binding site [ion binding]; metal-binding site
391904004083	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
391904004084	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
391904004085	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
391904004086	SWIM zinc finger; Region: SWIM; pfam04434
391904004087	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
391904004088	GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439
391904004089	GIY-YIG motif/motif A; other site
391904004090	putative active site [active]
391904004091	putative metal binding site [ion binding]; other site
391904004092	AAA domain; Region: AAA_22; pfam13401
391904004093	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
391904004094	Uncharacterized conserved protein [Function unknown]; Region: COG3410
391904004095	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
391904004096	homodimer interface [polypeptide binding]; other site
391904004097	chemical substrate binding site [chemical binding]; other site
391904004098	oligomer interface [polypeptide binding]; other site
391904004099	metal binding site [ion binding]; metal-binding site
391904004100	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
391904004101	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391904004102	Uncharacterized conserved protein [Function unknown]; Region: COG4715
391904004103	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
391904004104	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
391904004105	catalytic triad [active]
391904004106	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
391904004107	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
391904004108	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904004109	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
391904004110	active site
391904004111	motif I; other site
391904004112	motif II; other site
391904004113	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
391904004114	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
391904004115	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904004116	Walker A/P-loop; other site
391904004117	ATP binding site [chemical binding]; other site
391904004118	Q-loop/lid; other site
391904004119	ABC transporter signature motif; other site
391904004120	Walker B; other site
391904004121	D-loop; other site
391904004122	H-loop/switch region; other site
391904004123	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
391904004124	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
391904004125	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
391904004126	Glycosyl hydrolases related to GH101 family, GHL1-GHL3; Region: GHL1-3; pfam11308
391904004127	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
391904004128	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
391904004129	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
391904004130	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
391904004131	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
391904004132	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391904004133	NAD(P) binding site [chemical binding]; other site
391904004134	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
391904004135	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
391904004136	active site
391904004137	dimer interface [polypeptide binding]; other site
391904004138	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
391904004139	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
391904004140	active site
391904004141	FMN binding site [chemical binding]; other site
391904004142	substrate binding site [chemical binding]; other site
391904004143	3Fe-4S cluster binding site [ion binding]; other site
391904004144	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
391904004145	domain interface; other site
391904004146	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904004147	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904004148	DNA binding site [nucleotide binding]
391904004149	domain linker motif; other site
391904004150	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
391904004151	ligand binding site [chemical binding]; other site
391904004152	dimerization interface (open form) [polypeptide binding]; other site
391904004153	dimerization interface (closed form) [polypeptide binding]; other site
391904004154	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
391904004155	coproporphyrinogen III oxidase; Validated; Region: PRK05628
391904004156	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391904004157	FeS/SAM binding site; other site
391904004158	HemN C-terminal domain; Region: HemN_C; pfam06969
391904004159	GTP-binding protein LepA; Provisional; Region: PRK05433
391904004160	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
391904004161	G1 box; other site
391904004162	putative GEF interaction site [polypeptide binding]; other site
391904004163	GTP/Mg2+ binding site [chemical binding]; other site
391904004164	Switch I region; other site
391904004165	G2 box; other site
391904004166	G3 box; other site
391904004167	Switch II region; other site
391904004168	G4 box; other site
391904004169	G5 box; other site
391904004170	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
391904004171	Elongation Factor G, domain II; Region: EFG_II; pfam14492
391904004172	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
391904004173	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
391904004174	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
391904004175	UPF0126 domain; Region: UPF0126; pfam03458
391904004176	Predicted membrane protein [Function unknown]; Region: COG2860
391904004177	UPF0126 domain; Region: UPF0126; pfam03458
391904004178	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
391904004179	homodimer interface [polypeptide binding]; other site
391904004180	MazG family protein; Region: mazG; TIGR00444
391904004181	metal binding site [ion binding]; metal-binding site
391904004182	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659
391904004183	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904004184	active site
391904004185	Int/Topo IB signature motif; other site
391904004186	DNA binding site [nucleotide binding]
391904004187	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
391904004188	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
391904004189	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
391904004190	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904004191	non-specific DNA binding site [nucleotide binding]; other site
391904004192	salt bridge; other site
391904004193	sequence-specific DNA binding site [nucleotide binding]; other site
391904004194	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904004195	ERF superfamily; Region: ERF; pfam04404
391904004196	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
391904004197	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
391904004198	ssDNA binding site [nucleotide binding]; other site
391904004199	dimer interface [polypeptide binding]; other site
391904004200	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904004201	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
391904004202	Transcription factor WhiB; Region: Whib; pfam02467
391904004203	Nuclease-related domain; Region: NERD; pfam08378
391904004204	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
391904004205	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
391904004206	BRO family, N-terminal domain; Region: Bro-N; pfam02498
391904004207	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
391904004208	cofactor binding site; other site
391904004209	DNA binding site [nucleotide binding]
391904004210	substrate interaction site [chemical binding]; other site
391904004211	Prophage antirepressor [Transcription]; Region: COG3617
391904004212	BRO family, N-terminal domain; Region: Bro-N; smart01040
391904004213	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
391904004214	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
391904004215	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
391904004216	PemK-like protein; Region: PemK; pfam02452
391904004217	RelB antitoxin; Region: RelB; cl01171
391904004218	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020
391904004219	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
391904004220	active site
391904004221	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
391904004222	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; cl19531
391904004223	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
391904004224	Head fiber protein; Region: Phage_head_fibr; pfam11133
391904004225	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
391904004226	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
391904004227	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
391904004228	Interdomain contacts; other site
391904004229	Cytokine receptor motif; other site
391904004230	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842
391904004231	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904004232	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904004233	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904004234	LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.  The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417
391904004235	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
391904004236	active site
391904004237	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; pfam08230
391904004238	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
391904004239	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
391904004240	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
391904004241	homodimer interface [polypeptide binding]; other site
391904004242	substrate-cofactor binding pocket; other site
391904004243	catalytic residue [active]
391904004244	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
391904004245	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
391904004246	5S rRNA interface [nucleotide binding]; other site
391904004247	CTC domain interface [polypeptide binding]; other site
391904004248	L16 interface [polypeptide binding]; other site
391904004249	Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693
391904004250	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
391904004251	NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566
391904004252	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
391904004253	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
391904004254	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
391904004255	ligand binding site [chemical binding]; other site
391904004256	homodimer interface [polypeptide binding]; other site
391904004257	NAD(P) binding site [chemical binding]; other site
391904004258	trimer interface B [polypeptide binding]; other site
391904004259	trimer interface A [polypeptide binding]; other site
391904004260	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
391904004261	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
391904004262	acyl-activating enzyme (AAE) consensus motif; other site
391904004263	putative AMP binding site [chemical binding]; other site
391904004264	putative active site [active]
391904004265	putative CoA binding site [chemical binding]; other site
391904004266	GTPase Era; Reviewed; Region: era; PRK00089
391904004267	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
391904004268	G1 box; other site
391904004269	GTP/Mg2+ binding site [chemical binding]; other site
391904004270	Switch I region; other site
391904004271	G2 box; other site
391904004272	Switch II region; other site
391904004273	G3 box; other site
391904004274	G4 box; other site
391904004275	G5 box; other site
391904004276	KH domain; Region: KH_2; pfam07650
391904004277	Domain of unknown function DUF21; Region: DUF21; pfam01595
391904004278	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
391904004279	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
391904004280	Transporter associated domain; Region: CorC_HlyC; smart01091
391904004281	metal-binding heat shock protein; Provisional; Region: PRK00016
391904004282	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
391904004283	PhoH-like protein; Region: PhoH; pfam02562
391904004284	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
391904004285	nucleotide binding site/active site [active]
391904004286	HIT family signature motif; other site
391904004287	catalytic residue [active]
391904004288	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
391904004289	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
391904004290	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
391904004291	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
391904004292	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
391904004293	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
391904004294	ligand binding site; other site
391904004295	oligomer interface; other site
391904004296	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
391904004297	dimer interface [polypeptide binding]; other site
391904004298	N-terminal domain interface [polypeptide binding]; other site
391904004299	sulfate 1 binding site; other site
391904004300	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
391904004301	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
391904004302	trimerization site [polypeptide binding]; other site
391904004303	active site
391904004304	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
391904004305	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904004306	catalytic residue [active]
391904004307	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
391904004308	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
391904004309	Walker A/P-loop; other site
391904004310	ATP binding site [chemical binding]; other site
391904004311	Q-loop/lid; other site
391904004312	ABC transporter signature motif; other site
391904004313	Walker B; other site
391904004314	D-loop; other site
391904004315	H-loop/switch region; other site
391904004316	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
391904004317	FeS assembly protein SufD; Region: sufD; TIGR01981
391904004318	FeS assembly protein SufB; Region: sufB; TIGR01980
391904004319	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
391904004320	CTP synthetase; Validated; Region: pyrG; PRK05380
391904004321	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
391904004322	Catalytic site [active]
391904004323	active site
391904004324	UTP binding site [chemical binding]; other site
391904004325	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
391904004326	active site
391904004327	putative oxyanion hole; other site
391904004328	catalytic triad [active]
391904004329	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
391904004330	trimer interface [polypeptide binding]; other site
391904004331	active site
391904004332	dimer interface [polypeptide binding]; other site
391904004333	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
391904004334	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
391904004335	ADP binding site [chemical binding]; other site
391904004336	magnesium binding site [ion binding]; other site
391904004337	putative shikimate binding site; other site
391904004338	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
391904004339	active site
391904004340	dimer interface [polypeptide binding]; other site
391904004341	metal binding site [ion binding]; metal-binding site
391904004342	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
391904004343	Tetramer interface [polypeptide binding]; other site
391904004344	active site
391904004345	FMN-binding site [chemical binding]; other site
391904004346	YceG-like family; Region: YceG; pfam02618
391904004347	dimerization interface [polypeptide binding]; other site
391904004348	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
391904004349	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
391904004350	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
391904004351	motif 1; other site
391904004352	active site
391904004353	motif 2; other site
391904004354	motif 3; other site
391904004355	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
391904004356	DHHA1 domain; Region: DHHA1; pfam02272
391904004357	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
391904004358	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904004359	catalytic core [active]
391904004360	RelB antitoxin; Region: RelB; cl01171
391904004361	PemK-like protein; Region: PemK; pfam02452
391904004362	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
391904004363	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
391904004364	SdpI/YhfL protein family; Region: SdpI; pfam13630
391904004365	cytidine deaminase, homotetrameric; Region: cyt_deam_tetra; TIGR01354
391904004366	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
391904004367	active site
391904004368	catalytic motif [active]
391904004369	Zn binding site [ion binding]; other site
391904004370	Peptidase C26; Region: Peptidase_C26; pfam07722
391904004371	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
391904004372	catalytic triad [active]
391904004373	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
391904004374	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
391904004375	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391904004376	RNA binding surface [nucleotide binding]; other site
391904004377	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904004378	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904004379	Walker A/P-loop; other site
391904004380	ATP binding site [chemical binding]; other site
391904004381	Q-loop/lid; other site
391904004382	ABC transporter signature motif; other site
391904004383	Walker B; other site
391904004384	D-loop; other site
391904004385	H-loop/switch region; other site
391904004386	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904004387	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904004388	FtsX-like permease family; Region: FtsX; pfam02687
391904004389	Domain of unknown function (DUF4418); Region: DUF4418; pfam14387
391904004390	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
391904004391	Part of AAA domain; Region: AAA_19; pfam13245
391904004392	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
391904004393	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904004394	active site
391904004395	Sulfate transporter family; Region: Sulfate_transp; cl19250
391904004396	xanthine permease; Region: pbuX; TIGR03173
391904004397	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904004398	salt bridge; other site
391904004399	non-specific DNA binding site [nucleotide binding]; other site
391904004400	sequence-specific DNA binding site [nucleotide binding]; other site
391904004401	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904004402	Cation efflux family; Region: Cation_efflux; cl00316
391904004403	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
391904004404	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
391904004405	catalytic triad [active]
391904004406	conserved cis-peptide bond; other site
391904004407	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
391904004408	conserved cys residue [active]
391904004409	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
391904004410	oxyanion hole [active]
391904004411	Helix-turn-helix domain; Region: HTH_17; pfam12728
391904004412	PIN domain; Region: PIN_3; pfam13470
391904004413	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
391904004414	Divergent AAA domain; Region: AAA_4; pfam04326
391904004415	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
391904004416	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
391904004417	ABC-2 type transporter; Region: ABC2_membrane; cl17235
391904004418	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
391904004419	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904004420	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904004421	Walker A/P-loop; other site
391904004422	ATP binding site [chemical binding]; other site
391904004423	Q-loop/lid; other site
391904004424	ABC transporter signature motif; other site
391904004425	Walker B; other site
391904004426	D-loop; other site
391904004427	H-loop/switch region; other site
391904004428	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
391904004429	Histidine kinase; Region: HisKA_3; pfam07730
391904004430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904004431	ATP binding site [chemical binding]; other site
391904004432	Mg2+ binding site [ion binding]; other site
391904004433	G-X-G motif; other site
391904004434	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904004435	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904004436	active site
391904004437	phosphorylation site [posttranslational modification]
391904004438	intermolecular recognition site; other site
391904004439	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904004440	DNA binding residues [nucleotide binding]
391904004441	dimerization interface [polypeptide binding]; other site
391904004442	TIGR00153 family protein; Region: TIGR00153
391904004443	Phosphate transporter family; Region: PHO4; pfam01384
391904004444	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
391904004445	Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128
391904004446	active site
391904004447	catalytic site [active]
391904004448	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
391904004449	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
391904004450	ATP binding site [chemical binding]; other site
391904004451	putative Mg++ binding site [ion binding]; other site
391904004452	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904004453	nucleotide binding region [chemical binding]; other site
391904004454	ATP-binding site [chemical binding]; other site
391904004455	A-type inclusion like protein; Provisional; Region: PHA02896
391904004456	Sulfate transporter family; Region: Sulfate_transp; cl19250
391904004457	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
391904004458	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904004459	catalytic core [active]
391904004460	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
391904004461	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904004462	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904004463	putative substrate translocation pore; other site
391904004464	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
391904004465	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
391904004466	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
391904004467	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
391904004468	G1 box; other site
391904004469	GTP/Mg2+ binding site [chemical binding]; other site
391904004470	Switch I region; other site
391904004471	G2 box; other site
391904004472	G3 box; other site
391904004473	Switch II region; other site
391904004474	G4 box; other site
391904004475	G5 box; other site
391904004476	Nucleoside recognition; Region: Gate; pfam07670
391904004477	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
391904004478	Nucleoside recognition; Region: Gate; pfam07670
391904004479	FeoA domain; Region: FeoA; pfam04023
391904004480	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904004481	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904004482	putative substrate translocation pore; other site
391904004483	FOG: CBS domain [General function prediction only]; Region: COG0517
391904004484	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636
391904004485	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
391904004486	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
391904004487	active site
391904004488	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
391904004489	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
391904004490	Uncharacterized protein containing a Zn-ribbon (DUF2116); Region: DUF2116; cl01683
391904004491	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
391904004492	active site
391904004493	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904004494	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904004495	Integrase core domain; Region: rve; pfam00665
391904004496	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
391904004497	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904004498	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
391904004499	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
391904004500	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904004501	Coenzyme A binding pocket [chemical binding]; other site
391904004502	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
391904004503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904004504	motif II; other site
391904004505	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
391904004506	PrgI family protein; Region: PrgI; pfam12666
391904004507	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
391904004508	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
391904004509	DNA-binding interface [nucleotide binding]; DNA binding site
391904004510	Integrase core domain; Region: rve; pfam00665
391904004511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904004512	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
391904004513	Walker A motif; other site
391904004514	ATP binding site [chemical binding]; other site
391904004515	Walker B motif; other site
391904004516	arginine finger; other site
391904004517	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904004518	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659
391904004519	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391904004520	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904004521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904004522	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904004523	putative substrate translocation pore; other site
391904004524	HipA-like C-terminal domain; Region: HipA_C; pfam07804
391904004525	RelB antitoxin; Region: RelB; cl01171
391904004526	PemK-like protein; Region: PemK; pfam02452
391904004527	Cupin domain; Region: Cupin_2; cl17218
391904004528	Methyltransferase domain; Region: Methyltransf_31; pfam13847
391904004529	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904004530	S-adenosylmethionine binding site [chemical binding]; other site
391904004531	hypothetical protein; Provisional; Region: PRK11770
391904004532	Domain of unknown function (DUF307); Region: DUF307; pfam03733
391904004533	Domain of unknown function (DUF307); Region: DUF307; pfam03733
391904004534	Fic family protein [Function unknown]; Region: COG3177
391904004535	Fic/DOC family; Region: Fic; pfam02661
391904004536	MarR family; Region: MarR_2; cl17246
391904004537	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
391904004538	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
391904004539	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904004540	Walker A/P-loop; other site
391904004541	ATP binding site [chemical binding]; other site
391904004542	Q-loop/lid; other site
391904004543	ABC transporter signature motif; other site
391904004544	Walker B; other site
391904004545	D-loop; other site
391904004546	H-loop/switch region; other site
391904004547	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
391904004548	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
391904004549	TfoX C-terminal domain; Region: TfoX_C; pfam04994
391904004550	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
391904004551	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
391904004552	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
391904004553	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
391904004554	GTP-binding protein YchF; Reviewed; Region: PRK09601
391904004555	YchF GTPase; Region: YchF; cd01900
391904004556	G1 box; other site
391904004557	GTP/Mg2+ binding site [chemical binding]; other site
391904004558	Switch I region; other site
391904004559	G2 box; other site
391904004560	Switch II region; other site
391904004561	G3 box; other site
391904004562	G4 box; other site
391904004563	G5 box; other site
391904004564	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
391904004565	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
391904004566	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
391904004567	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391904004568	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
391904004569	Putative lysophospholipase; Region: Hydrolase_4; cl19140
391904004570	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904004571	Histidine kinase; Region: HisKA_3; pfam07730
391904004572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904004573	ATP binding site [chemical binding]; other site
391904004574	Mg2+ binding site [ion binding]; other site
391904004575	G-X-G motif; other site
391904004576	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904004577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904004578	active site
391904004579	phosphorylation site [posttranslational modification]
391904004580	intermolecular recognition site; other site
391904004581	dimerization interface [polypeptide binding]; other site
391904004582	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904004583	DNA binding residues [nucleotide binding]
391904004584	dimerization interface [polypeptide binding]; other site
391904004585	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904004586	FtsX-like permease family; Region: FtsX; pfam02687
391904004587	FtsX-like permease family; Region: FtsX; pfam02687
391904004588	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904004589	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904004590	Walker A/P-loop; other site
391904004591	ATP binding site [chemical binding]; other site
391904004592	Q-loop/lid; other site
391904004593	ABC transporter signature motif; other site
391904004594	Walker B; other site
391904004595	D-loop; other site
391904004596	H-loop/switch region; other site
391904004597	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
391904004598	homodimer interface [polypeptide binding]; other site
391904004599	substrate-cofactor binding pocket; other site
391904004600	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904004601	catalytic residue [active]
391904004602	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
391904004603	dimer interface [polypeptide binding]; other site
391904004604	pyridoxal binding site [chemical binding]; other site
391904004605	ATP binding site [chemical binding]; other site
391904004606	hypothetical protein; Provisional; Region: PRK14681
391904004607	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
391904004608	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
391904004609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904004610	Walker A motif; other site
391904004611	ATP binding site [chemical binding]; other site
391904004612	Walker B motif; other site
391904004613	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
391904004614	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
391904004615	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
391904004616	L-aspartate oxidase; Provisional; Region: PRK06175
391904004617	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
391904004618	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
391904004619	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
391904004620	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
391904004621	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
391904004622	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
391904004623	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
391904004624	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
391904004625	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
391904004626	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
391904004627	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904004628	Walker A motif; other site
391904004629	ATP binding site [chemical binding]; other site
391904004630	Walker B motif; other site
391904004631	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
391904004632	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
391904004633	oligomer interface [polypeptide binding]; other site
391904004634	active site residues [active]
391904004635	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
391904004636	oligomer interface [polypeptide binding]; other site
391904004637	active site residues [active]
391904004638	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
391904004639	putative ion selectivity filter; other site
391904004640	putative pore gating glutamate residue; other site
391904004641	trigger factor; Provisional; Region: tig; PRK01490
391904004642	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
391904004643	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
391904004644	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
391904004645	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
391904004646	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
391904004647	active site
391904004648	catalytic site [active]
391904004649	substrate binding site [chemical binding]; other site
391904004650	HRDC domain; Region: HRDC; pfam00570
391904004651	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
391904004652	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
391904004653	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
391904004654	FeS/SAM binding site; other site
391904004655	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
391904004656	Pyruvate formate lyase 1; Region: PFL1; cd01678
391904004657	coenzyme A binding site [chemical binding]; other site
391904004658	active site
391904004659	catalytic residues [active]
391904004660	glycine loop; other site
391904004661	NAD synthetase; Provisional; Region: PRK13981
391904004662	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
391904004663	multimer interface [polypeptide binding]; other site
391904004664	active site
391904004665	catalytic triad [active]
391904004666	protein interface 1 [polypeptide binding]; other site
391904004667	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
391904004668	homodimer interface [polypeptide binding]; other site
391904004669	NAD binding pocket [chemical binding]; other site
391904004670	ATP binding pocket [chemical binding]; other site
391904004671	Mg binding site [ion binding]; other site
391904004672	active-site loop [active]
391904004673	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
391904004674	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
391904004675	metal binding site [ion binding]; metal-binding site
391904004676	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904004677	dimer interface [polypeptide binding]; other site
391904004678	conserved gate region; other site
391904004679	putative PBP binding loops; other site
391904004680	ABC-ATPase subunit interface; other site
391904004681	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
391904004682	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
391904004683	Walker A/P-loop; other site
391904004684	ATP binding site [chemical binding]; other site
391904004685	Q-loop/lid; other site
391904004686	ABC transporter signature motif; other site
391904004687	Walker B; other site
391904004688	D-loop; other site
391904004689	H-loop/switch region; other site
391904004690	NIL domain; Region: NIL; pfam09383
391904004691	NLPA lipoprotein; Region: Lipoprotein_9; cl19159
391904004692	putative phosphoketolase; Provisional; Region: PRK05261
391904004693	XFP N-terminal domain; Region: XFP_N; pfam09364
391904004694	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
391904004695	XFP C-terminal domain; Region: XFP_C; pfam09363
391904004696	GMP synthase; Reviewed; Region: guaA; PRK00074
391904004697	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
391904004698	AMP/PPi binding site [chemical binding]; other site
391904004699	candidate oxyanion hole; other site
391904004700	catalytic triad [active]
391904004701	potential glutamine specificity residues [chemical binding]; other site
391904004702	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
391904004703	ATP Binding subdomain [chemical binding]; other site
391904004704	Ligand Binding sites [chemical binding]; other site
391904004705	Dimerization subdomain; other site
391904004706	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
391904004707	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
391904004708	catalytic triad [active]
391904004709	catalytic triad [active]
391904004710	oxyanion hole [active]
391904004711	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
391904004712	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
391904004713	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904004714	active site
391904004715	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
391904004716	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
391904004717	Substrate binding site; other site
391904004718	Mg++ binding site; other site
391904004719	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
391904004720	active site
391904004721	substrate binding site [chemical binding]; other site
391904004722	CoA binding site [chemical binding]; other site
391904004723	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
391904004724	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904004725	catalytic core [active]
391904004726	AAA domain; Region: AAA_26; pfam13500
391904004727	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
391904004728	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
391904004729	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
391904004730	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
391904004731	hinge; other site
391904004732	active site
391904004733	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
391904004734	active site
391904004735	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
391904004736	active site
391904004737	DNA binding site [nucleotide binding]
391904004738	Int/Topo IB signature motif; other site
391904004739	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
391904004740	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
391904004741	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
391904004742	active site
391904004743	catalytic site [active]
391904004744	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
391904004745	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
391904004746	dimer interface [polypeptide binding]; other site
391904004747	ADP-ribose binding site [chemical binding]; other site
391904004748	active site
391904004749	nudix motif; other site
391904004750	metal binding site [ion binding]; metal-binding site
391904004751	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
391904004752	DNA polymerase I; Provisional; Region: PRK05755
391904004753	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
391904004754	active site
391904004755	metal binding site 1 [ion binding]; metal-binding site
391904004756	putative 5' ssDNA interaction site; other site
391904004757	metal binding site 3; metal-binding site
391904004758	metal binding site 2 [ion binding]; metal-binding site
391904004759	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
391904004760	putative DNA binding site [nucleotide binding]; other site
391904004761	putative metal binding site [ion binding]; other site
391904004762	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
391904004763	active site
391904004764	substrate binding site [chemical binding]; other site
391904004765	catalytic site [active]
391904004766	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
391904004767	active site
391904004768	DNA binding site [nucleotide binding]
391904004769	catalytic site [active]
391904004770	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
391904004771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904004772	active site
391904004773	phosphorylation site [posttranslational modification]
391904004774	intermolecular recognition site; other site
391904004775	dimerization interface [polypeptide binding]; other site
391904004776	ANTAR domain; Region: ANTAR; pfam03861
391904004777	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
391904004778	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
391904004779	domain interfaces; other site
391904004780	active site
391904004781	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
391904004782	excinuclease ABC subunit B; Provisional; Region: PRK05298
391904004783	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
391904004784	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904004785	nucleotide binding region [chemical binding]; other site
391904004786	ATP-binding site [chemical binding]; other site
391904004787	Ultra-violet resistance protein B; Region: UvrB; pfam12344
391904004788	UvrB/uvrC motif; Region: UVR; pfam02151
391904004789	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904004790	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904004791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904004792	active site
391904004793	phosphorylation site [posttranslational modification]
391904004794	intermolecular recognition site; other site
391904004795	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904004796	DNA binding residues [nucleotide binding]
391904004797	dimerization interface [polypeptide binding]; other site
391904004798	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
391904004799	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
391904004800	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
391904004801	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904004802	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
391904004803	Walker A/P-loop; other site
391904004804	ATP binding site [chemical binding]; other site
391904004805	Q-loop/lid; other site
391904004806	ABC transporter signature motif; other site
391904004807	Walker B; other site
391904004808	D-loop; other site
391904004809	H-loop/switch region; other site
391904004810	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
391904004811	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
391904004812	CoA-binding site [chemical binding]; other site
391904004813	ATP-binding [chemical binding]; other site
391904004814	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
391904004815	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
391904004816	RNA binding site [nucleotide binding]; other site
391904004817	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
391904004818	RNA binding site [nucleotide binding]; other site
391904004819	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
391904004820	RNA binding site [nucleotide binding]; other site
391904004821	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
391904004822	RNA binding site [nucleotide binding]; other site
391904004823	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
391904004824	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
391904004825	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
391904004826	homodimer interface [polypeptide binding]; other site
391904004827	NADP binding site [chemical binding]; other site
391904004828	substrate binding site [chemical binding]; other site
391904004829	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
391904004830	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
391904004831	metal binding site [ion binding]; metal-binding site
391904004832	Serine-rich region of AP3B1, clathrin-adaptor complex; Region: SEEEED; cl19208
391904004833	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
391904004834	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
391904004835	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
391904004836	ABC-ATPase subunit  interface; other site
391904004837	dimer interface [polypeptide binding]; other site
391904004838	putative PBP binding regions; other site
391904004839	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
391904004840	homotrimer interaction site [polypeptide binding]; other site
391904004841	zinc binding site [ion binding]; other site
391904004842	CDP-binding sites; other site
391904004843	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
391904004844	glycogen branching enzyme; Provisional; Region: PRK05402
391904004845	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
391904004846	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
391904004847	active site
391904004848	catalytic site [active]
391904004849	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
391904004850	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
391904004851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904004852	active site
391904004853	phosphorylation site [posttranslational modification]
391904004854	intermolecular recognition site; other site
391904004855	dimerization interface [polypeptide binding]; other site
391904004856	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
391904004857	DNA binding site [nucleotide binding]
391904004858	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391904004859	L-lactate permease; Region: Lactate_perm; cl00701
391904004860	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
391904004861	dimerization interface [polypeptide binding]; other site
391904004862	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391904004863	dimer interface [polypeptide binding]; other site
391904004864	phosphorylation site [posttranslational modification]
391904004865	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904004866	ATP binding site [chemical binding]; other site
391904004867	Mg2+ binding site [ion binding]; other site
391904004868	G-X-G motif; other site
391904004869	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
391904004870	Catalytic site [active]
391904004871	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
391904004872	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904004873	active site
391904004874	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
391904004875	Eukaryotic phosphomannomutase; Region: PMM; cl17107
391904004876	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
391904004877	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
391904004878	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391904004879	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
391904004880	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
391904004881	Transcription factor WhiB; Region: Whib; pfam02467
391904004882	Enhancer of Polycomb C-terminus; Region: E_Pc_C; pfam06752
391904004883	Family of unknown function (DUF566); Region: DUF566; pfam04484
391904004884	Transcriptional regulator [Transcription]; Region: LytR; COG1316
391904004885	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
391904004886	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
391904004887	AAA domain; Region: AAA_17; cl19128
391904004888	Transcription factor WhiB; Region: Whib; pfam02467
391904004889	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
391904004890	PAS fold; Region: PAS_4; pfam08448
391904004891	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
391904004892	Histidine kinase; Region: HisKA_2; pfam07568
391904004893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904004894	ATP binding site [chemical binding]; other site
391904004895	Mg2+ binding site [ion binding]; other site
391904004896	G-X-G motif; other site
391904004897	Haemolysin-III related; Region: HlyIII; pfam03006
391904004898	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
391904004899	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
391904004900	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
391904004901	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
391904004902	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
391904004903	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
391904004904	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
391904004905	integrase; Provisional; Region: int; PHA02601
391904004906	AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657
391904004907	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659
391904004908	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
391904004909	active site
391904004910	catalytic residues [active]
391904004911	DNA binding site [nucleotide binding]
391904004912	Int/Topo IB signature motif; other site
391904004913	Fic family protein [Function unknown]; Region: COG3177
391904004914	Fic/DOC family; Region: Fic; pfam02661
391904004915	Uncharacterized conserved protein [Function unknown]; Region: COG4748
391904004916	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
391904004917	Domain of unknown function (DUF955); Region: DUF955; cl01076
391904004918	Helix-turn-helix; Region: HTH_3; pfam01381
391904004919	E1-like protein-activating enzyme Gsa7p/Apg7p; Region: E1_like_apg7; TIGR01381
391904004920	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
391904004921	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
391904004922	dimer interface [polypeptide binding]; other site
391904004923	ssDNA binding site [nucleotide binding]; other site
391904004924	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904004925	ParB-like nuclease domain; Region: ParB; smart00470
391904004926	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
391904004927	Helix-turn-helix domain; Region: HTH_36; pfam13730
391904004928	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
391904004929	active site
391904004930	catalytic site [active]
391904004931	substrate binding site [chemical binding]; other site
391904004932	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
391904004933	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
391904004934	Phage Terminase; Region: Terminase_1; cl19862
391904004935	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; cl19531
391904004936	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
391904004937	Phage capsid family; Region: Phage_capsid; pfam05065
391904004938	Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355
391904004939	Planctomycetes uncharacterized domain TIGR03000; Region: plancto_dom_1
391904004940	Phage-related minor tail protein [Function unknown]; Region: COG5280
391904004941	tape measure domain; Region: tape_meas_nterm; TIGR02675
391904004942	Phage-related protein [Function unknown]; Region: COG5412
391904004943	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
391904004944	Interdomain contacts; other site
391904004945	Cytokine receptor motif; other site
391904004946	Coiled-coil receptor-binding R-domain of colicin E2; Region: E2R135; pfam11570
391904004947	Histone H1-like nucleoprotein HC2; Region: HC2; cl19298
391904004948	LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.  The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417
391904004949	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
391904004950	active site
391904004951	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; pfam08230
391904004952	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
391904004953	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483
391904004954	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
391904004955	Protein of unknown function (DUF501); Region: DUF501; pfam04417
391904004956	Septum formation initiator; Region: DivIC; pfam04977
391904004957	enolase; Provisional; Region: eno; PRK00077
391904004958	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
391904004959	dimer interface [polypeptide binding]; other site
391904004960	metal binding site [ion binding]; metal-binding site
391904004961	substrate binding pocket [chemical binding]; other site
391904004962	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
391904004963	active site
391904004964	catalytic tetrad [active]
391904004965	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
391904004966	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
391904004967	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904004968	ATP binding site [chemical binding]; other site
391904004969	putative Mg++ binding site [ion binding]; other site
391904004970	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904004971	nucleotide binding region [chemical binding]; other site
391904004972	ATP-binding site [chemical binding]; other site
391904004973	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
391904004974	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
391904004975	putative active site [active]
391904004976	catalytic residue [active]
391904004977	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
391904004978	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
391904004979	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904004980	Coenzyme A binding pocket [chemical binding]; other site
391904004981	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
391904004982	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
391904004983	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
391904004984	active site
391904004985	(T/H)XGH motif; other site
391904004986	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
391904004987	putative catalytic cysteine [active]
391904004988	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
391904004989	dimer interface [polypeptide binding]; other site
391904004990	active site
391904004991	glycine-pyridoxal phosphate binding site [chemical binding]; other site
391904004992	folate binding site [chemical binding]; other site
391904004993	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
391904004994	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
391904004995	threonine synthase; Validated; Region: PRK09225
391904004996	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904004997	catalytic residue [active]
391904004998	Protein of unknown function (DUF1648); Region: DUF1648; cl19856
391904004999	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
391904005000	DNA-binding site [nucleotide binding]; DNA binding site
391904005001	Acyltransferase family; Region: Acyl_transf_3; cl19154
391904005002	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
391904005003	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
391904005004	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391904005005	Walker A/P-loop; other site
391904005006	ATP binding site [chemical binding]; other site
391904005007	Q-loop/lid; other site
391904005008	ABC transporter signature motif; other site
391904005009	Walker B; other site
391904005010	D-loop; other site
391904005011	H-loop/switch region; other site
391904005012	Predicted transcriptional regulators [Transcription]; Region: COG1725
391904005013	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
391904005014	DNA-binding site [nucleotide binding]; DNA binding site
391904005015	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904005016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904005017	active site
391904005018	phosphorylation site [posttranslational modification]
391904005019	intermolecular recognition site; other site
391904005020	dimerization interface [polypeptide binding]; other site
391904005021	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
391904005022	DNA binding residues [nucleotide binding]
391904005023	dimerization interface [polypeptide binding]; other site
391904005024	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904005025	Histidine kinase; Region: HisKA_3; pfam07730
391904005026	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
391904005027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904005028	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904005029	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
391904005030	Ligand Binding Site [chemical binding]; other site
391904005031	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
391904005032	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904005033	motif II; other site
391904005034	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
391904005035	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
391904005036	Walker A/P-loop; other site
391904005037	ATP binding site [chemical binding]; other site
391904005038	Q-loop/lid; other site
391904005039	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
391904005040	ABC transporter signature motif; other site
391904005041	Walker B; other site
391904005042	D-loop; other site
391904005043	H-loop/switch region; other site
391904005044	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
391904005045	Protein of unknown function (DUF342); Region: DUF342; cl19219
391904005046	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
391904005047	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391904005048	RNA binding surface [nucleotide binding]; other site
391904005049	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
391904005050	S-adenosylmethionine binding site [chemical binding]; other site
391904005051	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
391904005052	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
391904005053	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
391904005054	Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2; Region: BNIP2; pfam12496
391904005055	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
391904005056	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
391904005057	active site
391904005058	HIGH motif; other site
391904005059	dimer interface [polypeptide binding]; other site
391904005060	KMSKS motif; other site
391904005061	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
391904005062	RNA binding surface [nucleotide binding]; other site
391904005063	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
391904005064	Zn2+ binding site [ion binding]; other site
391904005065	Mg2+ binding site [ion binding]; other site
391904005066	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
391904005067	active site residue [active]
391904005068	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
391904005069	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
391904005070	ATP binding site [chemical binding]; other site
391904005071	substrate interface [chemical binding]; other site
391904005072	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
391904005073	ThiS interaction site; other site
391904005074	putative active site [active]
391904005075	tetramer interface [polypeptide binding]; other site
391904005076	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
391904005077	thiS-thiF/thiG interaction site; other site
391904005078	argininosuccinate lyase; Provisional; Region: PRK00855
391904005079	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
391904005080	active sites [active]
391904005081	tetramer interface [polypeptide binding]; other site
391904005082	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
391904005083	ANP binding site [chemical binding]; other site
391904005084	Substrate Binding Site II [chemical binding]; other site
391904005085	Substrate Binding Site I [chemical binding]; other site
391904005086	arginine repressor; Provisional; Region: PRK03341
391904005087	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
391904005088	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
391904005089	ornithine carbamoyltransferase; Provisional; Region: PRK00779
391904005090	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
391904005091	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
391904005092	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
391904005093	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
391904005094	inhibitor-cofactor binding pocket; inhibition site
391904005095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904005096	catalytic residue [active]
391904005097	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
391904005098	feedback inhibition sensing region; other site
391904005099	homohexameric interface [polypeptide binding]; other site
391904005100	nucleotide binding site [chemical binding]; other site
391904005101	N-acetyl-L-glutamate binding site [chemical binding]; other site
391904005102	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
391904005103	heterotetramer interface [polypeptide binding]; other site
391904005104	active site pocket [active]
391904005105	cleavage site
391904005106	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
391904005107	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
391904005108	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935
391904005109	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
391904005110	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
391904005111	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
391904005112	putative tRNA-binding site [nucleotide binding]; other site
391904005113	B3/4 domain; Region: B3_4; pfam03483
391904005114	tRNA synthetase B5 domain; Region: B5; smart00874
391904005115	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
391904005116	dimer interface [polypeptide binding]; other site
391904005117	motif 1; other site
391904005118	motif 3; other site
391904005119	motif 2; other site
391904005120	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
391904005121	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
391904005122	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
391904005123	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
391904005124	dimer interface [polypeptide binding]; other site
391904005125	motif 1; other site
391904005126	active site
391904005127	motif 2; other site
391904005128	motif 3; other site
391904005129	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
391904005130	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
391904005131	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
391904005132	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
391904005133	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
391904005134	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
391904005135	Walker A/P-loop; other site
391904005136	ATP binding site [chemical binding]; other site
391904005137	Q-loop/lid; other site
391904005138	ABC transporter signature motif; other site
391904005139	Walker B; other site
391904005140	D-loop; other site
391904005141	H-loop/switch region; other site
391904005142	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
391904005143	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
391904005144	Walker A/P-loop; other site
391904005145	ATP binding site [chemical binding]; other site
391904005146	Q-loop/lid; other site
391904005147	ABC transporter signature motif; other site
391904005148	Walker B; other site
391904005149	D-loop; other site
391904005150	H-loop/switch region; other site
391904005151	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
391904005152	hypothetical protein; Provisional; Region: PRK08201
391904005153	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
391904005154	active site
391904005155	metal binding site [ion binding]; metal-binding site
391904005156	dimer interface [polypeptide binding]; other site
391904005157	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
391904005158	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
391904005159	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
391904005160	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391904005161	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
391904005162	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
391904005163	glutamine synthetase, type I; Region: GlnA; TIGR00653
391904005164	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
391904005165	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
391904005166	Membrane transport protein; Region: Mem_trans; cl09117
391904005167	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
391904005168	putative trimer interface [polypeptide binding]; other site
391904005169	Predicted transcriptional regulators [Transcription]; Region: COG1695
391904005170	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
391904005171	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
391904005172	minor groove reading motif; other site
391904005173	helix-hairpin-helix signature motif; other site
391904005174	substrate binding pocket [chemical binding]; other site
391904005175	active site
391904005176	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
391904005177	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
391904005178	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
391904005179	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005180	Walker A/P-loop; other site
391904005181	ATP binding site [chemical binding]; other site
391904005182	Q-loop/lid; other site
391904005183	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005184	ABC transporter signature motif; other site
391904005185	Walker B; other site
391904005186	D-loop; other site
391904005187	H-loop/switch region; other site
391904005188	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005189	Walker A/P-loop; other site
391904005190	ATP binding site [chemical binding]; other site
391904005191	Q-loop/lid; other site
391904005192	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048
391904005193	ABC transporter signature motif; other site
391904005194	Walker B; other site
391904005195	D-loop; other site
391904005196	H-loop/switch region; other site
391904005197	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
391904005198	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
391904005199	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
391904005200	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
391904005201	active site
391904005202	catalytic triad [active]
391904005203	oxyanion hole [active]
391904005204	Domain of unknown function (DUF303); Region: DUF303; pfam03629
391904005205	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
391904005206	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
391904005207	dimer interface [polypeptide binding]; other site
391904005208	phosphorylation site [posttranslational modification]
391904005209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904005210	ATP binding site [chemical binding]; other site
391904005211	Mg2+ binding site [ion binding]; other site
391904005212	G-X-G motif; other site
391904005213	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904005214	Transposase; Region: HTH_Tnp_1; cl17663
391904005215	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904005216	putative transposase OrfB; Reviewed; Region: PHA02517
391904005217	HTH-like domain; Region: HTH_21; pfam13276
391904005218	Integrase core domain; Region: rve; pfam00665
391904005219	Integrase core domain; Region: rve_2; pfam13333
391904005220	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904005221	AAA domain; Region: AAA_14; pfam13173
391904005222	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904005223	FtsX-like permease family; Region: FtsX; pfam02687
391904005224	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904005225	FtsX-like permease family; Region: FtsX; pfam02687
391904005226	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904005227	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904005228	Walker A/P-loop; other site
391904005229	ATP binding site [chemical binding]; other site
391904005230	Q-loop/lid; other site
391904005231	ABC transporter signature motif; other site
391904005232	Walker B; other site
391904005233	D-loop; other site
391904005234	H-loop/switch region; other site
391904005235	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
391904005236	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
391904005237	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904005238	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904005239	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904005240	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
391904005241	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
391904005242	catalytic Zn binding site [ion binding]; other site
391904005243	NAD(P) binding site [chemical binding]; other site
391904005244	structural Zn binding site [ion binding]; other site
391904005245	CrcB-like protein; Region: CRCB; pfam02537
391904005246	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
391904005247	GtrA-like protein; Region: GtrA; pfam04138
391904005248	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
391904005249	elongation factor Tu; Reviewed; Region: PRK00049
391904005250	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
391904005251	G1 box; other site
391904005252	GEF interaction site [polypeptide binding]; other site
391904005253	GTP/Mg2+ binding site [chemical binding]; other site
391904005254	Switch I region; other site
391904005255	G2 box; other site
391904005256	G3 box; other site
391904005257	Switch II region; other site
391904005258	G4 box; other site
391904005259	G5 box; other site
391904005260	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
391904005261	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
391904005262	Antibiotic Binding Site [chemical binding]; other site
391904005263	elongation factor G; Reviewed; Region: PRK00007
391904005264	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
391904005265	G1 box; other site
391904005266	putative GEF interaction site [polypeptide binding]; other site
391904005267	GTP/Mg2+ binding site [chemical binding]; other site
391904005268	Switch I region; other site
391904005269	G2 box; other site
391904005270	G3 box; other site
391904005271	Switch II region; other site
391904005272	G4 box; other site
391904005273	G5 box; other site
391904005274	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
391904005275	Elongation Factor G, domain II; Region: EFG_II; pfam14492
391904005276	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
391904005277	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
391904005278	30S ribosomal protein S7; Validated; Region: PRK05302
391904005279	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
391904005280	S17 interaction site [polypeptide binding]; other site
391904005281	S8 interaction site; other site
391904005282	16S rRNA interaction site [nucleotide binding]; other site
391904005283	streptomycin interaction site [chemical binding]; other site
391904005284	23S rRNA interaction site [nucleotide binding]; other site
391904005285	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
391904005286	Abi-like protein; Region: Abi_2; pfam07751
391904005287	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904005288	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904005289	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904005290	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904005291	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904005292	non-specific DNA binding site [nucleotide binding]; other site
391904005293	salt bridge; other site
391904005294	sequence-specific DNA binding site [nucleotide binding]; other site
391904005295	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
391904005296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904005297	Walker A motif; other site
391904005298	ATP binding site [chemical binding]; other site
391904005299	Walker B motif; other site
391904005300	arginine finger; other site
391904005301	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
391904005302	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904005303	DNA-binding interface [nucleotide binding]; DNA binding site
391904005304	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904005305	Transposase; Region: HTH_Tnp_1; cl17663
391904005306	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904005307	putative transposase OrfB; Reviewed; Region: PHA02517
391904005308	HTH-like domain; Region: HTH_21; pfam13276
391904005309	Integrase core domain; Region: rve; pfam00665
391904005310	Integrase core domain; Region: rve_2; pfam13333
391904005311	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
391904005312	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005313	Walker A/P-loop; other site
391904005314	ATP binding site [chemical binding]; other site
391904005315	Q-loop/lid; other site
391904005316	ABC transporter signature motif; other site
391904005317	Walker B; other site
391904005318	D-loop; other site
391904005319	H-loop/switch region; other site
391904005320	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
391904005321	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
391904005322	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
391904005323	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
391904005324	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904005325	catalytic residue [active]
391904005326	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
391904005327	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391904005328	LL-diaminopimelate aminotransferase; Region: DapC_direct; TIGR03540
391904005329	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904005330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904005331	homodimer interface [polypeptide binding]; other site
391904005332	catalytic residue [active]
391904005333	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
391904005334	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391904005335	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
391904005336	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
391904005337	ATP binding site [chemical binding]; other site
391904005338	active site
391904005339	substrate binding site [chemical binding]; other site
391904005340	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
391904005341	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
391904005342	dimerization interface [polypeptide binding]; other site
391904005343	ATP binding site [chemical binding]; other site
391904005344	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
391904005345	dimerization interface [polypeptide binding]; other site
391904005346	ATP binding site [chemical binding]; other site
391904005347	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
391904005348	putative active site [active]
391904005349	catalytic triad [active]
391904005350	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
391904005351	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
391904005352	zinc-ribbons; Region: zinc-ribbons_6; pfam07191
391904005353	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
391904005354	putative active site [active]
391904005355	HipA N-terminal domain; Region: Couple_hipA; pfam13657
391904005356	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
391904005357	HipA-like N-terminal domain; Region: HipA_N; pfam07805
391904005358	HipA-like C-terminal domain; Region: HipA_C; pfam07804
391904005359	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904005360	non-specific DNA binding site [nucleotide binding]; other site
391904005361	salt bridge; other site
391904005362	sequence-specific DNA binding site [nucleotide binding]; other site
391904005363	DNA polymerase IV; Reviewed; Region: PRK03103
391904005364	Y-family of DNA polymerases; Region: PolY; cl12025
391904005365	active site
391904005366	DNA binding site [nucleotide binding]
391904005367	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
391904005368	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
391904005369	NAD binding site [chemical binding]; other site
391904005370	guanine deaminase; Region: guan_deamin; TIGR02967
391904005371	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312
391904005372	active site
391904005373	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
391904005374	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904005375	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391904005376	substrate binding pocket [chemical binding]; other site
391904005377	membrane-bound complex binding site; other site
391904005378	hinge residues; other site
391904005379	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
391904005380	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005381	dimer interface [polypeptide binding]; other site
391904005382	conserved gate region; other site
391904005383	putative PBP binding loops; other site
391904005384	ABC-ATPase subunit interface; other site
391904005385	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391904005386	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005387	Walker A/P-loop; other site
391904005388	ATP binding site [chemical binding]; other site
391904005389	Q-loop/lid; other site
391904005390	ABC transporter signature motif; other site
391904005391	Walker B; other site
391904005392	D-loop; other site
391904005393	H-loop/switch region; other site
391904005394	amidophosphoribosyltransferase; Provisional; Region: PRK07272
391904005395	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
391904005396	active site
391904005397	tetramer interface [polypeptide binding]; other site
391904005398	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904005399	active site
391904005400	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
391904005401	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
391904005402	dimerization interface [polypeptide binding]; other site
391904005403	putative ATP binding site [chemical binding]; other site
391904005404	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
391904005405	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
391904005406	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
391904005407	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
391904005408	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
391904005409	NAD(P) binding site [chemical binding]; other site
391904005410	catalytic residues [active]
391904005411	Sulfatase; Region: Sulfatase; pfam00884
391904005412	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
391904005413	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
391904005414	metal binding site [ion binding]; metal-binding site
391904005415	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
391904005416	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
391904005417	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
391904005418	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
391904005419	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
391904005420	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
391904005421	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
391904005422	intersubunit interface [polypeptide binding]; other site
391904005423	Predicted permease; Region: DUF318; cl17795
391904005424	TIGR03943 family protein; Region: TIGR03943
391904005425	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
391904005426	metal binding site 2 [ion binding]; metal-binding site
391904005427	putative DNA binding helix; other site
391904005428	metal binding site 1 [ion binding]; metal-binding site
391904005429	dimer interface [polypeptide binding]; other site
391904005430	structural Zn2+ binding site [ion binding]; other site
391904005431	FtsX-like permease family; Region: FtsX; pfam02687
391904005432	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
391904005433	metal binding site 2 [ion binding]; metal-binding site
391904005434	putative DNA binding helix; other site
391904005435	metal binding site 1 [ion binding]; metal-binding site
391904005436	dimer interface [polypeptide binding]; other site
391904005437	structural Zn2+ binding site [ion binding]; other site
391904005438	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
391904005439	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391904005440	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
391904005441	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
391904005442	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
391904005443	NAD(P) binding site [chemical binding]; other site
391904005444	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
391904005445	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
391904005446	TPP-binding site; other site
391904005447	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
391904005448	PYR/PP interface [polypeptide binding]; other site
391904005449	dimer interface [polypeptide binding]; other site
391904005450	TPP binding site [chemical binding]; other site
391904005451	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
391904005452	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904005453	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904005454	FtsX-like permease family; Region: FtsX; pfam02687
391904005455	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
391904005456	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904005457	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904005458	Walker A/P-loop; other site
391904005459	ATP binding site [chemical binding]; other site
391904005460	Q-loop/lid; other site
391904005461	ABC transporter signature motif; other site
391904005462	Walker B; other site
391904005463	D-loop; other site
391904005464	H-loop/switch region; other site
391904005465	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
391904005466	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
391904005467	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
391904005468	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
391904005469	putative active site [active]
391904005470	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
391904005471	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
391904005472	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
391904005473	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
391904005474	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
391904005475	DNA-binding site [nucleotide binding]; DNA binding site
391904005476	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904005477	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904005478	homodimer interface [polypeptide binding]; other site
391904005479	catalytic residue [active]
391904005480	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
391904005481	predicted active site [active]
391904005482	catalytic triad [active]
391904005483	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
391904005484	active site
391904005485	multimer interface [polypeptide binding]; other site
391904005486	DNA primase, catalytic core; Region: dnaG; TIGR01391
391904005487	CHC2 zinc finger; Region: zf-CHC2; cl17510
391904005488	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
391904005489	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
391904005490	active site
391904005491	metal binding site [ion binding]; metal-binding site
391904005492	interdomain interaction site; other site
391904005493	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
391904005494	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
391904005495	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
391904005496	Zn2+ binding site [ion binding]; other site
391904005497	Mg2+ binding site [ion binding]; other site
391904005498	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
391904005499	alanine racemase; Reviewed; Region: alr; PRK00053
391904005500	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
391904005501	active site
391904005502	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
391904005503	dimer interface [polypeptide binding]; other site
391904005504	substrate binding site [chemical binding]; other site
391904005505	catalytic residues [active]
391904005506	amino acid transporter; Region: 2A0306; TIGR00909
391904005507	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
391904005508	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
391904005509	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
391904005510	S-ribosylhomocysteinase; Provisional; Region: PRK02260
391904005511	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
391904005512	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
391904005513	ATP binding site [chemical binding]; other site
391904005514	putative Mg++ binding site [ion binding]; other site
391904005515	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
391904005516	nucleotide binding region [chemical binding]; other site
391904005517	ATP-binding site [chemical binding]; other site
391904005518	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
391904005519	HRDC domain; Region: HRDC; pfam00570
391904005520	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
391904005521	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
391904005522	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
391904005523	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904005524	catalytic residue [active]
391904005525	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
391904005526	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
391904005527	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904005528	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904005529	putative substrate translocation pore; other site
391904005530	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904005531	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
391904005532	active site
391904005533	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
391904005534	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904005535	Walker A/P-loop; other site
391904005536	ATP binding site [chemical binding]; other site
391904005537	Q-loop/lid; other site
391904005538	ABC transporter signature motif; other site
391904005539	Walker B; other site
391904005540	D-loop; other site
391904005541	H-loop/switch region; other site
391904005542	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
391904005543	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904005544	Walker A/P-loop; other site
391904005545	ATP binding site [chemical binding]; other site
391904005546	Q-loop/lid; other site
391904005547	ABC transporter signature motif; other site
391904005548	Walker B; other site
391904005549	D-loop; other site
391904005550	H-loop/switch region; other site
391904005551	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904005552	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005553	dimer interface [polypeptide binding]; other site
391904005554	conserved gate region; other site
391904005555	putative PBP binding loops; other site
391904005556	ABC-ATPase subunit interface; other site
391904005557	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904005558	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005559	dimer interface [polypeptide binding]; other site
391904005560	conserved gate region; other site
391904005561	putative PBP binding loops; other site
391904005562	ABC-ATPase subunit interface; other site
391904005563	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
391904005564	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
391904005565	Flavoprotein; Region: Flavoprotein; cl19190
391904005566	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
391904005567	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
391904005568	pantothenate kinase; Reviewed; Region: PRK13318
391904005569	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904005570	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904005571	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
391904005572	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
391904005573	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
391904005574	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
391904005575	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
391904005576	active site
391904005577	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
391904005578	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
391904005579	glutaminase active site [active]
391904005580	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
391904005581	dimer interface [polypeptide binding]; other site
391904005582	active site
391904005583	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
391904005584	dimer interface [polypeptide binding]; other site
391904005585	active site
391904005586	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
391904005587	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
391904005588	Walker A/P-loop; other site
391904005589	ATP binding site [chemical binding]; other site
391904005590	Q-loop/lid; other site
391904005591	ABC transporter signature motif; other site
391904005592	Walker B; other site
391904005593	D-loop; other site
391904005594	H-loop/switch region; other site
391904005595	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
391904005596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005597	dimer interface [polypeptide binding]; other site
391904005598	conserved gate region; other site
391904005599	ABC-ATPase subunit interface; other site
391904005600	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904005601	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391904005602	substrate binding pocket [chemical binding]; other site
391904005603	membrane-bound complex binding site; other site
391904005604	hinge residues; other site
391904005605	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
391904005606	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
391904005607	substrate binding pocket [chemical binding]; other site
391904005608	membrane-bound complex binding site; other site
391904005609	hinge residues; other site
391904005610	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
391904005611	SmpB-tmRNA interface; other site
391904005612	Surface antigen [General function prediction only]; Region: COG3942
391904005613	CHAP domain; Region: CHAP; pfam05257
391904005614	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
391904005615	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
391904005616	FtsX-like permease family; Region: FtsX; pfam02687
391904005617	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
391904005618	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005619	Walker A/P-loop; other site
391904005620	ATP binding site [chemical binding]; other site
391904005621	Q-loop/lid; other site
391904005622	ABC transporter signature motif; other site
391904005623	Walker B; other site
391904005624	D-loop; other site
391904005625	H-loop/switch region; other site
391904005626	peptide chain release factor 2; Validated; Region: prfB; PRK00578
391904005627	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
391904005628	This domain is found in peptide chain release factors; Region: PCRF; smart00937
391904005629	RF-1 domain; Region: RF-1; pfam00472
391904005630	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904005631	AAA domain; Region: AAA_14; pfam13173
391904005632	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904005633	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
391904005634	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
391904005635	active site
391904005636	catalytic site [active]
391904005637	substrate binding site [chemical binding]; other site
391904005638	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
391904005639	active site
391904005640	catalytic residues [active]
391904005641	metal binding site [ion binding]; metal-binding site
391904005642	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
391904005643	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
391904005644	active site
391904005645	substrate binding site [chemical binding]; other site
391904005646	metal binding site [ion binding]; metal-binding site
391904005647	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
391904005648	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
391904005649	Zn binding site [ion binding]; other site
391904005650	ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838
391904005651	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
391904005652	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
391904005653	RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
391904005654	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
391904005655	dimer interface [polypeptide binding]; other site
391904005656	active site
391904005657	catalytic residue [active]
391904005658	dihydrodipicolinate reductase; Provisional; Region: PRK00048
391904005659	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
391904005660	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
391904005661	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904005662	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904005663	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
391904005664	Part of AAA domain; Region: AAA_19; pfam13245
391904005665	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
391904005666	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904005667	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904005668	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
391904005669	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
391904005670	Catalytic domain of Protein Kinases; Region: PKc; cd00180
391904005671	active site
391904005672	ATP binding site [chemical binding]; other site
391904005673	substrate binding site [chemical binding]; other site
391904005674	activation loop (A-loop); other site
391904005675	MoxR-like ATPases [General function prediction only]; Region: COG0714
391904005676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904005677	Walker A motif; other site
391904005678	ATP binding site [chemical binding]; other site
391904005679	Walker B motif; other site
391904005680	arginine finger; other site
391904005681	Protein of unknown function DUF58; Region: DUF58; pfam01882
391904005682	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
391904005683	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
391904005684	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
391904005685	phosphopeptide binding site; other site
391904005686	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
391904005687	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
391904005688	beta and beta' interface [polypeptide binding]; other site
391904005689	beta' and sigma factor interface [polypeptide binding]; other site
391904005690	Zn-binding [ion binding]; other site
391904005691	active site region [active]
391904005692	catalytic site [active]
391904005693	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
391904005694	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
391904005695	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
391904005696	G-loop; other site
391904005697	DNA binding site [nucleotide binding]
391904005698	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
391904005699	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
391904005700	RPB12 interaction site [polypeptide binding]; other site
391904005701	RPB1 interaction site [polypeptide binding]; other site
391904005702	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
391904005703	RPB10 interaction site [polypeptide binding]; other site
391904005704	RPB11 interaction site [polypeptide binding]; other site
391904005705	RPB3 interaction site [polypeptide binding]; other site
391904005706	Alphaherpesvirus tegument protein US9; Region: Herpes_US9; pfam06072
391904005707	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
391904005708	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
391904005709	minor groove reading motif; other site
391904005710	helix-hairpin-helix signature motif; other site
391904005711	active site
391904005712	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
391904005713	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
391904005714	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
391904005715	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
391904005716	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
391904005717	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
391904005718	substrate binding [chemical binding]; other site
391904005719	active site
391904005720	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
391904005721	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904005722	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904005723	DNA binding site [nucleotide binding]
391904005724	domain linker motif; other site
391904005725	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
391904005726	putative dimerization interface [polypeptide binding]; other site
391904005727	putative ligand binding site [chemical binding]; other site
391904005728	Protein of unknown function, DUF624; Region: DUF624; cl02369
391904005729	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904005730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005731	dimer interface [polypeptide binding]; other site
391904005732	conserved gate region; other site
391904005733	putative PBP binding loops; other site
391904005734	ABC-ATPase subunit interface; other site
391904005735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904005736	dimer interface [polypeptide binding]; other site
391904005737	conserved gate region; other site
391904005738	putative PBP binding loops; other site
391904005739	ABC-ATPase subunit interface; other site
391904005740	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904005741	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904005742	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
391904005743	galactokinase; Provisional; Region: PRK00555
391904005744	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
391904005745	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
391904005746	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
391904005747	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
391904005748	dimer interface [polypeptide binding]; other site
391904005749	active site
391904005750	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
391904005751	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
391904005752	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
391904005753	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
391904005754	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
391904005755	quinone interaction residues [chemical binding]; other site
391904005756	active site
391904005757	catalytic residues [active]
391904005758	FMN binding site [chemical binding]; other site
391904005759	substrate binding site [chemical binding]; other site
391904005760	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
391904005761	active site
391904005762	FMN binding site [chemical binding]; other site
391904005763	substrate binding site [chemical binding]; other site
391904005764	homotetramer interface [polypeptide binding]; other site
391904005765	catalytic residue [active]
391904005766	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
391904005767	Transglycosylase; Region: Transgly; pfam00912
391904005768	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
391904005769	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
391904005770	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
391904005771	ligand binding site [chemical binding]; other site
391904005772	flexible hinge region; other site
391904005773	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
391904005774	putative switch regulator; other site
391904005775	non-specific DNA interactions [nucleotide binding]; other site
391904005776	DNA binding site [nucleotide binding]
391904005777	sequence specific DNA binding site [nucleotide binding]; other site
391904005778	putative cAMP binding site [chemical binding]; other site
391904005779	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
391904005780	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
391904005781	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
391904005782	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
391904005783	Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl19874
391904005784	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
391904005785	lipoyl attachment site [posttranslational modification]; other site
391904005786	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
391904005787	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
391904005788	putative NADH binding site [chemical binding]; other site
391904005789	putative active site [active]
391904005790	nudix motif; other site
391904005791	putative metal binding site [ion binding]; other site
391904005792	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
391904005793	Putative lysophospholipase; Region: Hydrolase_4; cl19140
391904005794	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
391904005795	nudix motif; other site
391904005796	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
391904005797	catalytic residues [active]
391904005798	Domain of unknown function (DUF348); Region: DUF348; pfam03990
391904005799	G5 domain; Region: G5; pfam07501
391904005800	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
391904005801	catalytic residue [active]
391904005802	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904005803	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904005804	non-specific DNA binding site [nucleotide binding]; other site
391904005805	salt bridge; other site
391904005806	sequence-specific DNA binding site [nucleotide binding]; other site
391904005807	HipA N-terminal domain; Region: Couple_hipA; pfam13657
391904005808	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
391904005809	HipA-like N-terminal domain; Region: HipA_N; pfam07805
391904005810	HipA-like C-terminal domain; Region: HipA_C; pfam07804
391904005811	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
391904005812	Chain length determinant protein; Region: Wzz; pfam02706
391904005813	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
391904005814	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
391904005815	AAA domain; Region: AAA_31; pfam13614
391904005816	Abi-like protein; Region: Abi_2; pfam07751
391904005817	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904005818	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904005819	Integrase core domain; Region: rve; pfam00665
391904005820	Acyltransferase family; Region: Acyl_transf_3; pfam01757
391904005821	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904005822	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904005823	non-specific DNA binding site [nucleotide binding]; other site
391904005824	salt bridge; other site
391904005825	DNA-binding transcriptional regulator Cro; Region: P22_Cro; cl18770
391904005826	sequence-specific DNA binding site [nucleotide binding]; other site
391904005827	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
391904005828	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
391904005829	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
391904005830	Winged helix-turn helix; Region: HTH_29; pfam13551
391904005831	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904005832	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904005833	Walker A motif; other site
391904005834	ATP binding site [chemical binding]; other site
391904005835	Walker B motif; other site
391904005836	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904005837	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904005838	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904005839	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
391904005840	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
391904005841	non-specific DNA binding site [nucleotide binding]; other site
391904005842	salt bridge; other site
391904005843	sequence-specific DNA binding site [nucleotide binding]; other site
391904005844	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
391904005845	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
391904005846	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
391904005847	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391904005848	active site
391904005849	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
391904005850	Transposase, Mutator family; Region: Transposase_mut; cl19537
391904005851	Core-2/I-Branching enzyme; Region: Branch; pfam02485
391904005852	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
391904005853	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391904005854	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391904005855	active site
391904005856	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
391904005857	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
391904005858	putative ADP-binding pocket [chemical binding]; other site
391904005859	EpsG family; Region: EpsG; pfam14897
391904005860	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
391904005861	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391904005862	active site
391904005863	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
391904005864	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904005865	Low molecular weight phosphatase family; Region: LMWPc; cd00115
391904005866	active site
391904005867	Transposase; Region: DEDD_Tnp_IS110; pfam01548
391904005868	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
391904005869	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
391904005870	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
391904005871	CoA binding domain; Region: CoA_binding; cl17356
391904005872	Bacterial sugar transferase; Region: Bac_transf; pfam02397
391904005873	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
391904005874	Divergent AAA domain; Region: AAA_4; pfam04326
391904005875	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
391904005876	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
391904005877	Transposase; Region: DDE_Tnp_ISL3; pfam01610
391904005878	AAA ATPase domain; Region: AAA_16; pfam13191
391904005879	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
391904005880	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
391904005881	putative active site [active]
391904005882	putative metal binding site [ion binding]; other site
391904005883	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
391904005884	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
391904005885	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
391904005886	Pup-ligase protein; Region: Pup_ligase; cl15463
391904005887	ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687
391904005888	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
391904005889	active site
391904005890	Pup-ligase protein; Region: Pup_ligase; cl15463
391904005891	proteasome ATPase; Region: pup_AAA; TIGR03689
391904005892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904005893	Walker A motif; other site
391904005894	ATP binding site [chemical binding]; other site
391904005895	Walker B motif; other site
391904005896	arginine finger; other site
391904005897	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
391904005898	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
391904005899	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904005900	motif II; other site
391904005901	primosome assembly protein PriA; Provisional; Region: PRK14873
391904005902	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
391904005903	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904005904	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
391904005905	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
391904005906	putative active site [active]
391904005907	substrate binding site [chemical binding]; other site
391904005908	putative cosubstrate binding site; other site
391904005909	catalytic site [active]
391904005910	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
391904005911	substrate binding site [chemical binding]; other site
391904005912	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
391904005913	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
391904005914	S-adenosylmethionine synthetase; Validated; Region: PRK05250
391904005915	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
391904005916	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
391904005917	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
391904005918	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904005919	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904005920	FtsX-like permease family; Region: FtsX; pfam02687
391904005921	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904005922	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904005923	FtsX-like permease family; Region: FtsX; pfam02687
391904005924	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904005925	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904005926	Walker A/P-loop; other site
391904005927	ATP binding site [chemical binding]; other site
391904005928	Q-loop/lid; other site
391904005929	ABC transporter signature motif; other site
391904005930	Walker B; other site
391904005931	D-loop; other site
391904005932	H-loop/switch region; other site
391904005933	Low molecular weight phosphatase family; Region: LMWPc; cd00115
391904005934	active site
391904005935	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
391904005936	folate binding site [chemical binding]; other site
391904005937	NADP+ binding site [chemical binding]; other site
391904005938	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
391904005939	dimerization interface [polypeptide binding]; other site
391904005940	active site
391904005941	OsmC-like protein; Region: OsmC; pfam02566
391904005942	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
391904005943	Ligand Binding Site [chemical binding]; other site
391904005944	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
391904005945	Ligand Binding Site [chemical binding]; other site
391904005946	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
391904005947	NlpC/P60 family; Region: NLPC_P60; pfam00877
391904005948	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
391904005949	NlpC/P60 family; Region: NLPC_P60; cl17555
391904005950	CHAP domain; Region: CHAP; pfam05257
391904005951	phosphoserine aminotransferase; Provisional; Region: PRK03080
391904005952	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
391904005953	catalytic residue [active]
391904005954	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
391904005955	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904005956	ATP binding site [chemical binding]; other site
391904005957	Mg2+ binding site [ion binding]; other site
391904005958	G-X-G motif; other site
391904005959	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
391904005960	PhoU domain; Region: PhoU; pfam01895
391904005961	PhoU domain; Region: PhoU; pfam01895
391904005962	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904005963	catalytic core [active]
391904005964	Resolvase, N terminal domain; Region: Resolvase; pfam00239
391904005965	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
391904005966	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
391904005967	DNA-binding interface [nucleotide binding]; DNA binding site
391904005968	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
391904005969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904005970	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
391904005971	Walker A motif; other site
391904005972	ATP binding site [chemical binding]; other site
391904005973	Walker B motif; other site
391904005974	arginine finger; other site
391904005975	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
391904005976	short chain dehydrogenase; Region: adh_short; pfam00106
391904005977	ATP binding site [chemical binding]; other site
391904005978	substrate interface [chemical binding]; other site
391904005979	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
391904005980	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904005981	putative substrate translocation pore; other site
391904005982	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904005983	1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962
391904005984	putative active site [active]
391904005985	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
391904005986	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
391904005987	dimer interface [polypeptide binding]; other site
391904005988	putative anticodon binding site; other site
391904005989	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
391904005990	motif 1; other site
391904005991	dimer interface [polypeptide binding]; other site
391904005992	active site
391904005993	motif 2; other site
391904005994	motif 3; other site
391904005995	MFS transport protein AraJ; Provisional; Region: PRK10091
391904005996	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904005997	putative substrate translocation pore; other site
391904005998	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
391904005999	active site
391904006000	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
391904006001	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
391904006002	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
391904006003	putative active site [active]
391904006004	putative metal binding site [ion binding]; other site
391904006005	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
391904006006	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391904006007	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391904006008	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
391904006009	binding surface
391904006010	TPR motif; other site
391904006011	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391904006012	Tetratricopeptide repeat; Region: TPR_12; pfam13424
391904006013	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
391904006014	Protein of unknown function (DUF4125); Region: DUF4125; pfam13526
391904006015	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
391904006016	Short repeat of unknown function (DUF308); Region: DUF308; pfam03729
391904006017	PspC domain; Region: PspC; pfam04024
391904006018	Glycine-rich region of argonaut; Region: Gly-rich_Ago1; pfam12764
391904006019	PspC domain; Region: PspC; pfam04024
391904006020	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
391904006021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
391904006022	ATP binding site [chemical binding]; other site
391904006023	Mg2+ binding site [ion binding]; other site
391904006024	G-X-G motif; other site
391904006025	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904006026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904006027	active site
391904006028	phosphorylation site [posttranslational modification]
391904006029	intermolecular recognition site; other site
391904006030	dimerization interface [polypeptide binding]; other site
391904006031	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904006032	DNA binding residues [nucleotide binding]
391904006033	dimerization interface [polypeptide binding]; other site
391904006034	UDP-glucose 4-epimerase; Region: PLN02240
391904006035	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
391904006036	NAD binding site [chemical binding]; other site
391904006037	homodimer interface [polypeptide binding]; other site
391904006038	active site
391904006039	substrate binding site [chemical binding]; other site
391904006040	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
391904006041	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
391904006042	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
391904006043	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
391904006044	Phosphotransferase enzyme family; Region: APH; pfam01636
391904006045	active site
391904006046	substrate binding site [chemical binding]; other site
391904006047	ATP binding site [chemical binding]; other site
391904006048	1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336
391904006049	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006050	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006051	dimer interface [polypeptide binding]; other site
391904006052	conserved gate region; other site
391904006053	putative PBP binding loops; other site
391904006054	ABC-ATPase subunit interface; other site
391904006055	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
391904006056	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006057	dimer interface [polypeptide binding]; other site
391904006058	conserved gate region; other site
391904006059	ABC-ATPase subunit interface; other site
391904006060	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006061	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006062	seryl-tRNA synthetase; Provisional; Region: PRK05431
391904006063	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
391904006064	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
391904006065	motif 1; other site
391904006066	dimer interface [polypeptide binding]; other site
391904006067	active site
391904006068	motif 2; other site
391904006069	motif 3; other site
391904006070	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
391904006071	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
391904006072	PRD domain; Region: PRD; pfam00874
391904006073	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904006074	Transposase; Region: HTH_Tnp_1; cl17663
391904006075	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904006076	putative transposase OrfB; Reviewed; Region: PHA02517
391904006077	HTH-like domain; Region: HTH_21; pfam13276
391904006078	Integrase core domain; Region: rve; pfam00665
391904006079	Integrase core domain; Region: rve_2; pfam13333
391904006080	CAT RNA binding domain; Region: CAT_RBD; smart01061
391904006081	PRD domain; Region: PRD; pfam00874
391904006082	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
391904006083	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
391904006084	active site turn [active]
391904006085	phosphorylation site [posttranslational modification]
391904006086	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
391904006087	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
391904006088	HPr interaction site; other site
391904006089	glycerol kinase (GK) interaction site [polypeptide binding]; other site
391904006090	active site
391904006091	phosphorylation site [posttranslational modification]
391904006092	phosphoglucomutase; Validated; Region: PRK07564
391904006093	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
391904006094	active site
391904006095	substrate binding site [chemical binding]; other site
391904006096	metal binding site [ion binding]; metal-binding site
391904006097	Transcriptional regulator; Region: Rrf2; pfam02082
391904006098	Rrf2 family protein; Region: rrf2_super; TIGR00738
391904006099	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
391904006100	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391904006101	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
391904006102	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
391904006103	RNA/DNA hybrid binding site [nucleotide binding]; other site
391904006104	active site
391904006105	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
391904006106	tetramer (dimer of dimers) interface [polypeptide binding]; other site
391904006107	active site
391904006108	dimer interface [polypeptide binding]; other site
391904006109	DNA repair protein RadA; Provisional; Region: PRK11823
391904006110	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
391904006111	Walker A motif; other site
391904006112	ATP binding site [chemical binding]; other site
391904006113	Walker B motif; other site
391904006114	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
391904006115	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
391904006116	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
391904006117	active site
391904006118	Riboflavin kinase; Region: Flavokinase; smart00904
391904006119	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
391904006120	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
391904006121	RNA binding site [nucleotide binding]; other site
391904006122	active site
391904006123	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
391904006124	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
391904006125	translation initiation factor IF-2; Validated; Region: infB; PRK05306
391904006126	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
391904006127	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
391904006128	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
391904006129	G1 box; other site
391904006130	putative GEF interaction site [polypeptide binding]; other site
391904006131	GTP/Mg2+ binding site [chemical binding]; other site
391904006132	Switch I region; other site
391904006133	G2 box; other site
391904006134	G3 box; other site
391904006135	Switch II region; other site
391904006136	G4 box; other site
391904006137	G5 box; other site
391904006138	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
391904006139	Translation-initiation factor 2; Region: IF-2; pfam11987
391904006140	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
391904006141	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
391904006142	NusA N-terminal domain; Region: NusA_N; pfam08529
391904006143	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
391904006144	RNA binding site [nucleotide binding]; other site
391904006145	homodimer interface [polypeptide binding]; other site
391904006146	NusA-like KH domain; Region: KH_5; pfam13184
391904006147	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
391904006148	G-X-X-G motif; other site
391904006149	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006150	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006151	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006152	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006153	dimer interface [polypeptide binding]; other site
391904006154	conserved gate region; other site
391904006155	putative PBP binding loops; other site
391904006156	ABC-ATPase subunit interface; other site
391904006157	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
391904006158	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006159	dimer interface [polypeptide binding]; other site
391904006160	conserved gate region; other site
391904006161	putative PBP binding loops; other site
391904006162	ABC-ATPase subunit interface; other site
391904006163	AAA domain; Region: AAA_14; pfam13173
391904006164	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904006165	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904006166	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
391904006167	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
391904006168	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
391904006169	Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl17448
391904006170	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl19824
391904006171	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
391904006172	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
391904006173	dimerization interface 3.5A [polypeptide binding]; other site
391904006174	active site
391904006175	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
391904006176	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
391904006177	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
391904006178	alphaNTD homodimer interface [polypeptide binding]; other site
391904006179	alphaNTD - beta interaction site [polypeptide binding]; other site
391904006180	alphaNTD - beta' interaction site [polypeptide binding]; other site
391904006181	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
391904006182	30S ribosomal protein S11; Validated; Region: PRK05309
391904006183	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
391904006184	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
391904006185	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
391904006186	rRNA binding site [nucleotide binding]; other site
391904006187	predicted 30S ribosome binding site; other site
391904006188	adenylate kinase; Reviewed; Region: adk; PRK00279
391904006189	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
391904006190	AMP-binding site [chemical binding]; other site
391904006191	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
391904006192	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
391904006193	SecY translocase; Region: SecY; pfam00344
391904006194	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
391904006195	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
391904006196	23S rRNA binding site [nucleotide binding]; other site
391904006197	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
391904006198	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
391904006199	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
391904006200	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
391904006201	23S rRNA interface [nucleotide binding]; other site
391904006202	L21e interface [polypeptide binding]; other site
391904006203	5S rRNA interface [nucleotide binding]; other site
391904006204	L27 interface [polypeptide binding]; other site
391904006205	L5 interface [polypeptide binding]; other site
391904006206	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
391904006207	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
391904006208	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
391904006209	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
391904006210	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
391904006211	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
391904006212	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
391904006213	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
391904006214	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
391904006215	RNA binding site [nucleotide binding]; other site
391904006216	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
391904006217	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
391904006218	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
391904006219	23S rRNA interface [nucleotide binding]; other site
391904006220	putative translocon interaction site; other site
391904006221	signal recognition particle (SRP54) interaction site; other site
391904006222	L23 interface [polypeptide binding]; other site
391904006223	trigger factor interaction site; other site
391904006224	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
391904006225	23S rRNA interface [nucleotide binding]; other site
391904006226	5S rRNA interface [nucleotide binding]; other site
391904006227	putative antibiotic binding site [chemical binding]; other site
391904006228	L25 interface [polypeptide binding]; other site
391904006229	L27 interface [polypeptide binding]; other site
391904006230	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
391904006231	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
391904006232	G-X-X-G motif; other site
391904006233	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
391904006234	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
391904006235	putative translocon binding site; other site
391904006236	protein-rRNA interface [nucleotide binding]; other site
391904006237	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
391904006238	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
391904006239	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
391904006240	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
391904006241	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
391904006242	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
391904006243	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
391904006244	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
391904006245	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
391904006246	YwiC-like protein; Region: YwiC; pfam14256
391904006247	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
391904006248	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
391904006249	putative catalytic cysteine [active]
391904006250	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
391904006251	putative active site [active]
391904006252	metal binding site [ion binding]; metal-binding site
391904006253	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
391904006254	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904006255	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904006256	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
391904006257	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
391904006258	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
391904006259	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
391904006260	active site
391904006261	catalytic site [active]
391904006262	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
391904006263	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
391904006264	23S rRNA interface [nucleotide binding]; other site
391904006265	L3 interface [polypeptide binding]; other site
391904006266	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
391904006267	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
391904006268	Uncharacterized conserved protein [Function unknown]; Region: COG1739
391904006269	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
391904006270	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
391904006271	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
391904006272	dimerization interface [polypeptide binding]; other site
391904006273	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
391904006274	NAD binding site [chemical binding]; other site
391904006275	ligand binding site [chemical binding]; other site
391904006276	catalytic site [active]
391904006277	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
391904006278	active site
391904006279	DNA polymerase IV; Validated; Region: PRK02406
391904006280	DNA binding site [nucleotide binding]
391904006281	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
391904006282	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904006283	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904006284	homodimer interface [polypeptide binding]; other site
391904006285	catalytic residue [active]
391904006286	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
391904006287	Ferredoxin [Energy production and conversion]; Region: COG1146
391904006288	4Fe-4S binding domain; Region: Fer4; pfam00037
391904006289	amino acid transporter; Region: 2A0306; TIGR00909
391904006290	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
391904006291	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
391904006292	FAD binding domain; Region: FAD_binding_4; pfam01565
391904006293	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
391904006294	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
391904006295	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
391904006296	oligomerisation interface [polypeptide binding]; other site
391904006297	mobile loop; other site
391904006298	roof hairpin; other site
391904006299	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
391904006300	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
391904006301	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
391904006302	Zinc ribbon domain; Region: Zn-ribbon_8; cl00993
391904006303	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
391904006304	Part of AAA domain; Region: AAA_19; pfam13245
391904006305	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
391904006306	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
391904006307	phosphopeptide binding site; other site
391904006308	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
391904006309	peripheral dimer interface [polypeptide binding]; other site
391904006310	core dimer interface [polypeptide binding]; other site
391904006311	L10 interface [polypeptide binding]; other site
391904006312	L11 interface [polypeptide binding]; other site
391904006313	putative EF-Tu interaction site [polypeptide binding]; other site
391904006314	putative EF-G interaction site [polypeptide binding]; other site
391904006315	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
391904006316	23S rRNA interface [nucleotide binding]; other site
391904006317	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
391904006318	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
391904006319	Sulfate transporter family; Region: Sulfate_transp; cl19250
391904006320	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
391904006321	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
391904006322	oligomer interface [polypeptide binding]; other site
391904006323	RNA binding site [nucleotide binding]; other site
391904006324	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
391904006325	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
391904006326	RNase E interface [polypeptide binding]; other site
391904006327	trimer interface [polypeptide binding]; other site
391904006328	active site
391904006329	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
391904006330	putative nucleic acid binding region [nucleotide binding]; other site
391904006331	G-X-X-G motif; other site
391904006332	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
391904006333	RNA binding site [nucleotide binding]; other site
391904006334	domain interface; other site
391904006335	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
391904006336	16S/18S rRNA binding site [nucleotide binding]; other site
391904006337	S13e-L30e interaction site [polypeptide binding]; other site
391904006338	25S rRNA binding site [nucleotide binding]; other site
391904006339	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904006340	Q-loop/lid; other site
391904006341	Walker B; other site
391904006342	D-loop; other site
391904006343	H-loop/switch region; other site
391904006344	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
391904006345	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
391904006346	Walker A/P-loop; other site
391904006347	ATP binding site [chemical binding]; other site
391904006348	Q-loop/lid; other site
391904006349	ABC transporter signature motif; other site
391904006350	Walker B; other site
391904006351	D-loop; other site
391904006352	H-loop/switch region; other site
391904006353	type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893
391904006354	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
391904006355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
391904006356	active site
391904006357	phosphorylation site [posttranslational modification]
391904006358	intermolecular recognition site; other site
391904006359	dimerization interface [polypeptide binding]; other site
391904006360	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
391904006361	DNA binding residues [nucleotide binding]
391904006362	dimerization interface [polypeptide binding]; other site
391904006363	Helix-turn-helix domain; Region: HTH_38; pfam13936
391904006364	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
391904006365	Integrase core domain; Region: rve; pfam00665
391904006366	Domain of unknown function (DUF4564); Region: DUF4564; pfam15169
391904006367	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
391904006368	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
391904006369	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
391904006370	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
391904006371	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
391904006372	phosphate binding site [ion binding]; other site
391904006373	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
391904006374	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
391904006375	putative active site [active]
391904006376	putative catalytic site [active]
391904006377	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
391904006378	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
391904006379	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
391904006380	NAD(P) binding site [chemical binding]; other site
391904006381	active site
391904006382	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
391904006383	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
391904006384	active site
391904006385	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
391904006386	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
391904006387	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
391904006388	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
391904006389	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
391904006390	ATP-grasp domain; Region: ATP-grasp_4; cl17255
391904006391	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
391904006392	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
391904006393	carboxyltransferase (CT) interaction site; other site
391904006394	biotinylation site [posttranslational modification]; other site
391904006395	Protein of unknown function (DUF3816); Region: DUF3816; cl17272
391904006396	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
391904006397	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
391904006398	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
391904006399	Transcriptional regulator [Transcription]; Region: IclR; COG1414
391904006400	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
391904006401	Bacterial transcriptional regulator; Region: IclR; pfam01614
391904006402	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
391904006403	Transcriptional regulator [Transcription]; Region: IclR; COG1414
391904006404	Bacterial transcriptional regulator; Region: IclR; pfam01614
391904006405	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
391904006406	mRNA/rRNA interface [nucleotide binding]; other site
391904006407	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
391904006408	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
391904006409	23S rRNA interface [nucleotide binding]; other site
391904006410	L7/L12 interface [polypeptide binding]; other site
391904006411	putative thiostrepton binding site; other site
391904006412	L25 interface [polypeptide binding]; other site
391904006413	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
391904006414	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
391904006415	putative homodimer interface [polypeptide binding]; other site
391904006416	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
391904006417	heterodimer interface [polypeptide binding]; other site
391904006418	homodimer interface [polypeptide binding]; other site
391904006419	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
391904006420	aspartate aminotransferase; Provisional; Region: PRK05764
391904006421	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904006422	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904006423	homodimer interface [polypeptide binding]; other site
391904006424	catalytic residue [active]
391904006425	gamma-glutamyl kinase; Provisional; Region: PRK05429
391904006426	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
391904006427	nucleotide binding site [chemical binding]; other site
391904006428	homotetrameric interface [polypeptide binding]; other site
391904006429	putative phosphate binding site [ion binding]; other site
391904006430	putative allosteric binding site; other site
391904006431	PUA domain; Region: PUA; pfam01472
391904006432	GTPase CgtA; Reviewed; Region: obgE; PRK12296
391904006433	GTP1/OBG; Region: GTP1_OBG; pfam01018
391904006434	Obg GTPase; Region: Obg; cd01898
391904006435	G1 box; other site
391904006436	GTP/Mg2+ binding site [chemical binding]; other site
391904006437	Switch I region; other site
391904006438	G2 box; other site
391904006439	G3 box; other site
391904006440	Switch II region; other site
391904006441	G4 box; other site
391904006442	G5 box; other site
391904006443	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
391904006444	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
391904006445	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
391904006446	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
391904006447	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
391904006448	homodimer interface [polypeptide binding]; other site
391904006449	oligonucleotide binding site [chemical binding]; other site
391904006450	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
391904006451	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
391904006452	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
391904006453	metal binding site [ion binding]; metal-binding site
391904006454	putative dimer interface [polypeptide binding]; other site
391904006455	Predicted permeases [General function prediction only]; Region: COG0679
391904006456	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
391904006457	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
391904006458	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
391904006459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904006460	putative substrate translocation pore; other site
391904006461	short chain dehydrogenase; Provisional; Region: PRK08628
391904006462	classical (c) SDRs; Region: SDR_c; cd05233
391904006463	NAD(P) binding site [chemical binding]; other site
391904006464	active site
391904006465	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
391904006466	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
391904006467	metal binding site [ion binding]; metal-binding site
391904006468	substrate binding pocket [chemical binding]; other site
391904006469	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904006470	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904006471	DNA binding site [nucleotide binding]
391904006472	domain linker motif; other site
391904006473	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
391904006474	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
391904006475	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
391904006476	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904006477	Walker A/P-loop; other site
391904006478	ATP binding site [chemical binding]; other site
391904006479	Q-loop/lid; other site
391904006480	ABC transporter signature motif; other site
391904006481	Walker B; other site
391904006482	D-loop; other site
391904006483	H-loop/switch region; other site
391904006484	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
391904006485	active site
391904006486	dimer interface [polypeptide binding]; other site
391904006487	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
391904006488	nudix motif; other site
391904006489	homoserine kinase; Provisional; Region: PRK01212
391904006490	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
391904006491	homoserine dehydrogenase; Provisional; Region: PRK06349
391904006492	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
391904006493	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
391904006494	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
391904006495	diaminopimelate decarboxylase; Region: lysA; TIGR01048
391904006496	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
391904006497	active site
391904006498	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
391904006499	substrate binding site [chemical binding]; other site
391904006500	catalytic residues [active]
391904006501	dimer interface [polypeptide binding]; other site
391904006502	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
391904006503	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
391904006504	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
391904006505	active site
391904006506	HIGH motif; other site
391904006507	KMSK motif region; other site
391904006508	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
391904006509	tRNA binding surface [nucleotide binding]; other site
391904006510	anticodon binding site; other site
391904006511	Transcriptional regulator [Transcription]; Region: LysR; COG0583
391904006512	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
391904006513	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
391904006514	dimerization interface [polypeptide binding]; other site
391904006515	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
391904006516	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
391904006517	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904006518	homodimer interface [polypeptide binding]; other site
391904006519	catalytic residue [active]
391904006520	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
391904006521	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
391904006522	hinge; other site
391904006523	active site
391904006524	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
391904006525	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391904006526	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
391904006527	Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810
391904006528	active site
391904006529	FMN binding site [chemical binding]; other site
391904006530	substrate binding site [chemical binding]; other site
391904006531	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
391904006532	substrate binding site [chemical binding]; other site
391904006533	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
391904006534	substrate binding site [chemical binding]; other site
391904006535	ligand binding site [chemical binding]; other site
391904006536	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
391904006537	Transcriptional regulator [Transcription]; Region: IclR; COG1414
391904006538	Bacterial transcriptional regulator; Region: IclR; pfam01614
391904006539	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
391904006540	putative active site [active]
391904006541	putative metal binding site [ion binding]; other site
391904006542	polyphosphate kinase; Provisional; Region: PRK05443
391904006543	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
391904006544	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
391904006545	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
391904006546	putative domain interface [polypeptide binding]; other site
391904006547	putative active site [active]
391904006548	catalytic site [active]
391904006549	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
391904006550	putative domain interface [polypeptide binding]; other site
391904006551	putative active site [active]
391904006552	catalytic site [active]
391904006553	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
391904006554	active site
391904006555	Ap6A binding site [chemical binding]; other site
391904006556	nudix motif; other site
391904006557	metal binding site [ion binding]; metal-binding site
391904006558	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904006559	catalytic core [active]
391904006560	putative symporter YagG; Provisional; Region: PRK09669; cl15392
391904006561	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
391904006562	putative symporter YagG; Provisional; Region: PRK09669; cl15392
391904006563	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
391904006564	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
391904006565	Transposase; Region: HTH_Tnp_1; cl17663
391904006566	Helix-turn-helix domain; Region: HTH_28; pfam13518
391904006567	putative transposase OrfB; Reviewed; Region: PHA02517
391904006568	HTH-like domain; Region: HTH_21; pfam13276
391904006569	Integrase core domain; Region: rve; pfam00665
391904006570	Integrase core domain; Region: rve_2; pfam13333
391904006571	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
391904006572	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
391904006573	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
391904006574	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
391904006575	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
391904006576	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498
391904006577	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
391904006578	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
391904006579	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067
391904006580	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
391904006581	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
391904006582	inhibitor site; inhibition site
391904006583	active site
391904006584	dimer interface [polypeptide binding]; other site
391904006585	catalytic residue [active]
391904006586	short chain dehydrogenase; Provisional; Region: PRK08628
391904006587	classical (c) SDRs; Region: SDR_c; cd05233
391904006588	NAD(P) binding site [chemical binding]; other site
391904006589	active site
391904006590	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
391904006591	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
391904006592	metal binding site [ion binding]; metal-binding site
391904006593	substrate binding pocket [chemical binding]; other site
391904006594	Protein of unknown function, DUF624; Region: DUF624; cl02369
391904006595	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006597	dimer interface [polypeptide binding]; other site
391904006598	conserved gate region; other site
391904006599	ABC-ATPase subunit interface; other site
391904006600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006601	dimer interface [polypeptide binding]; other site
391904006602	conserved gate region; other site
391904006603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
391904006604	ABC-ATPase subunit interface; other site
391904006605	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006606	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006607	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006609	dimer interface [polypeptide binding]; other site
391904006610	conserved gate region; other site
391904006611	ABC-ATPase subunit interface; other site
391904006612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006613	dimer interface [polypeptide binding]; other site
391904006614	conserved gate region; other site
391904006615	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
391904006616	ABC-ATPase subunit interface; other site
391904006617	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006618	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006619	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
391904006620	catalytic site [active]
391904006621	BNR repeat-like domain; Region: BNR_2; pfam13088
391904006622	Asp-box motif; other site
391904006623	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
391904006624	inhibitor site; inhibition site
391904006625	active site
391904006626	dimer interface [polypeptide binding]; other site
391904006627	catalytic residue [active]
391904006628	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006629	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006630	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006631	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006632	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006633	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006634	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006635	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006636	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
391904006637	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
391904006638	putative active site [active]
391904006639	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
391904006640	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
391904006641	motif II; other site
391904006642	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006643	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
391904006644	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
391904006645	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
391904006646	RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
391904006647	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006649	dimer interface [polypeptide binding]; other site
391904006650	conserved gate region; other site
391904006651	putative PBP binding loops; other site
391904006652	ABC-ATPase subunit interface; other site
391904006653	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
391904006654	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006655	dimer interface [polypeptide binding]; other site
391904006656	conserved gate region; other site
391904006657	putative PBP binding loops; other site
391904006658	ABC-ATPase subunit interface; other site
391904006659	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
391904006660	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904006661	Walker A/P-loop; other site
391904006662	ATP binding site [chemical binding]; other site
391904006663	Q-loop/lid; other site
391904006664	ABC transporter signature motif; other site
391904006665	Walker B; other site
391904006666	D-loop; other site
391904006667	H-loop/switch region; other site
391904006668	Uncharacterized conserved protein [Function unknown]; Region: COG4283
391904006669	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
391904006670	active site
391904006671	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
391904006672	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006673	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
391904006674	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006676	dimer interface [polypeptide binding]; other site
391904006677	conserved gate region; other site
391904006678	putative PBP binding loops; other site
391904006679	ABC-ATPase subunit interface; other site
391904006680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006681	dimer interface [polypeptide binding]; other site
391904006682	conserved gate region; other site
391904006683	putative PBP binding loops; other site
391904006684	ABC-ATPase subunit interface; other site
391904006685	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
391904006686	active site
391904006687	catalytic site [active]
391904006688	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
391904006689	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
391904006690	active site
391904006691	nucleotide binding site [chemical binding]; other site
391904006692	HIGH motif; other site
391904006693	KMSKS motif; other site
391904006694	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
391904006695	Clp amino terminal domain; Region: Clp_N; pfam02861
391904006696	Clp amino terminal domain; Region: Clp_N; pfam02861
391904006697	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904006698	Walker A motif; other site
391904006699	ATP binding site [chemical binding]; other site
391904006700	Walker B motif; other site
391904006701	Protein of unknown function (DUF3435); Region: DUF3435; pfam11917
391904006702	arginine finger; other site
391904006703	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
391904006704	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904006705	Walker A motif; other site
391904006706	ATP binding site [chemical binding]; other site
391904006707	Walker B motif; other site
391904006708	arginine finger; other site
391904006709	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
391904006710	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
391904006711	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
391904006712	Coenzyme A binding pocket [chemical binding]; other site
391904006713	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
391904006714	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
391904006715	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
391904006716	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
391904006717	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
391904006718	UDP-galactopyranose mutase; Region: GLF; pfam03275
391904006719	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006721	dimer interface [polypeptide binding]; other site
391904006722	conserved gate region; other site
391904006723	putative PBP binding loops; other site
391904006724	ABC-ATPase subunit interface; other site
391904006725	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
391904006726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006727	dimer interface [polypeptide binding]; other site
391904006728	conserved gate region; other site
391904006729	putative PBP binding loops; other site
391904006730	ABC-ATPase subunit interface; other site
391904006731	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006732	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006733	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
391904006734	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
391904006735	Ligand binding site; other site
391904006736	Putative Catalytic site; other site
391904006737	DXD motif; other site
391904006738	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
391904006739	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391904006740	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391904006741	active site
391904006742	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
391904006743	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
391904006744	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
391904006745	Ligand binding site; other site
391904006746	metal-binding site
391904006747	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
391904006748	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
391904006749	Walker A/P-loop; other site
391904006750	ATP binding site [chemical binding]; other site
391904006751	Q-loop/lid; other site
391904006752	ABC transporter signature motif; other site
391904006753	Walker B; other site
391904006754	D-loop; other site
391904006755	H-loop/switch region; other site
391904006756	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
391904006757	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
391904006758	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
391904006759	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
391904006760	Ligand binding site; other site
391904006761	metal-binding site
391904006762	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
391904006763	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
391904006764	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
391904006765	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
391904006766	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
391904006767	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
391904006768	NAD binding site [chemical binding]; other site
391904006769	substrate binding site [chemical binding]; other site
391904006770	homodimer interface [polypeptide binding]; other site
391904006771	active site
391904006772	Acyltransferase family; Region: Acyl_transf_3; pfam01757
391904006773	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
391904006774	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904006775	FtsX-like permease family; Region: FtsX; pfam02687
391904006776	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
391904006777	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904006778	Walker A/P-loop; other site
391904006779	ATP binding site [chemical binding]; other site
391904006780	Q-loop/lid; other site
391904006781	ABC transporter signature motif; other site
391904006782	Walker B; other site
391904006783	D-loop; other site
391904006784	H-loop/switch region; other site
391904006785	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
391904006786	Zn2+ binding site [ion binding]; other site
391904006787	Mg2+ binding site [ion binding]; other site
391904006788	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
391904006789	putative active site [active]
391904006790	putative dimer interface [polypeptide binding]; other site
391904006791	Amino acid permease; Region: AA_permease_2; pfam13520
391904006792	K+ potassium transporter; Region: K_trans; pfam02705
391904006793	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
391904006794	active site
391904006795	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
391904006796	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
391904006797	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094
391904006798	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
391904006799	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904006800	putative substrate translocation pore; other site
391904006801	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904006802	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904006803	nucleotide binding site [chemical binding]; other site
391904006804	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
391904006805	putative active site cavity [active]
391904006806	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
391904006807	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
391904006808	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
391904006809	Fic family protein [Function unknown]; Region: COG3177
391904006810	Fic/DOC family; Region: Fic; pfam02661
391904006811	Fic family protein [Function unknown]; Region: COG3177
391904006812	Fic/DOC family; Region: Fic; pfam02661
391904006813	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904006814	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904006815	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
391904006816	Walker A/P-loop; other site
391904006817	ATP binding site [chemical binding]; other site
391904006818	Q-loop/lid; other site
391904006819	ABC transporter signature motif; other site
391904006820	Walker B; other site
391904006821	D-loop; other site
391904006822	H-loop/switch region; other site
391904006823	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904006824	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904006825	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904006826	Walker A/P-loop; other site
391904006827	ATP binding site [chemical binding]; other site
391904006828	Q-loop/lid; other site
391904006829	ABC transporter signature motif; other site
391904006830	Walker B; other site
391904006831	D-loop; other site
391904006832	H-loop/switch region; other site
391904006833	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
391904006834	Archaeal ATPase; Region: Arch_ATPase; pfam01637
391904006835	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
391904006836	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904006837	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904006838	Walker A motif; other site
391904006839	ATP binding site [chemical binding]; other site
391904006840	Walker B motif; other site
391904006841	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904006842	Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004
391904006843	putative substrate binding site [chemical binding]; other site
391904006844	active site
391904006845	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006847	dimer interface [polypeptide binding]; other site
391904006848	conserved gate region; other site
391904006849	putative PBP binding loops; other site
391904006850	ABC-ATPase subunit interface; other site
391904006851	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
391904006852	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006853	dimer interface [polypeptide binding]; other site
391904006854	conserved gate region; other site
391904006855	putative PBP binding loops; other site
391904006856	ABC-ATPase subunit interface; other site
391904006857	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006858	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904006859	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904006860	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904006861	DNA binding site [nucleotide binding]
391904006862	domain linker motif; other site
391904006863	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904006864	ligand binding site [chemical binding]; other site
391904006865	dimerization interface [polypeptide binding]; other site
391904006866	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
391904006867	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
391904006868	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
391904006869	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
391904006870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
391904006871	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
391904006872	Walker A motif; other site
391904006873	ATP binding site [chemical binding]; other site
391904006874	Walker B motif; other site
391904006875	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
391904006876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904006877	H+ Antiporter protein; Region: 2A0121; TIGR00900
391904006878	putative substrate translocation pore; other site
391904006879	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
391904006880	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
391904006881	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
391904006882	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904006883	Walker A/P-loop; other site
391904006884	ATP binding site [chemical binding]; other site
391904006885	Q-loop/lid; other site
391904006886	ABC transporter signature motif; other site
391904006887	Walker B; other site
391904006888	D-loop; other site
391904006889	H-loop/switch region; other site
391904006890	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904006891	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
391904006892	Walker A/P-loop; other site
391904006893	ATP binding site [chemical binding]; other site
391904006894	Q-loop/lid; other site
391904006895	ABC transporter signature motif; other site
391904006896	Walker B; other site
391904006897	D-loop; other site
391904006898	H-loop/switch region; other site
391904006899	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
391904006900	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
391904006901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006902	dimer interface [polypeptide binding]; other site
391904006903	conserved gate region; other site
391904006904	putative PBP binding loops; other site
391904006905	ABC-ATPase subunit interface; other site
391904006906	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
391904006907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006908	dimer interface [polypeptide binding]; other site
391904006909	conserved gate region; other site
391904006910	putative PBP binding loops; other site
391904006911	ABC-ATPase subunit interface; other site
391904006912	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
391904006913	trimer interface [polypeptide binding]; other site
391904006914	active site
391904006915	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
391904006916	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
391904006917	active site
391904006918	HIGH motif; other site
391904006919	KMSKS motif; other site
391904006920	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
391904006921	tRNA binding surface [nucleotide binding]; other site
391904006922	anticodon binding site; other site
391904006923	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
391904006924	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
391904006925	putative SAM binding site [chemical binding]; other site
391904006926	putative homodimer interface [polypeptide binding]; other site
391904006927	MULE transposase domain; Region: MULE; pfam10551
391904006928	ApbE family; Region: ApbE; pfam02424
391904006929	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904006930	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904006931	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
391904006932	Walker A/P-loop; other site
391904006933	ATP binding site [chemical binding]; other site
391904006934	Q-loop/lid; other site
391904006935	ABC transporter signature motif; other site
391904006936	Walker B; other site
391904006937	D-loop; other site
391904006938	H-loop/switch region; other site
391904006939	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
391904006940	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
391904006941	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
391904006942	Walker A/P-loop; other site
391904006943	ATP binding site [chemical binding]; other site
391904006944	Q-loop/lid; other site
391904006945	ABC transporter signature motif; other site
391904006946	Walker B; other site
391904006947	D-loop; other site
391904006948	H-loop/switch region; other site
391904006949	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
391904006950	Transcriptional regulators [Transcription]; Region: MarR; COG1846
391904006951	putative Zn2+ binding site [ion binding]; other site
391904006952	putative DNA binding site [nucleotide binding]; other site
391904006953	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
391904006954	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
391904006955	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
391904006956	Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795
391904006957	Vps53-like, N-terminal; Region: Vps53_N; pfam04100
391904006958	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
391904006959	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
391904006960	FtsX-like permease family; Region: FtsX; pfam02687
391904006961	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
391904006962	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
391904006963	Walker A/P-loop; other site
391904006964	ATP binding site [chemical binding]; other site
391904006965	Q-loop/lid; other site
391904006966	ABC transporter signature motif; other site
391904006967	Walker B; other site
391904006968	D-loop; other site
391904006969	H-loop/switch region; other site
391904006970	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
391904006971	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
391904006972	Protein of unknown function, DUF624; Region: DUF624; pfam04854
391904006973	Protein of unknown function, DUF624; Region: DUF624; cl02369
391904006974	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006975	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006976	dimer interface [polypeptide binding]; other site
391904006977	conserved gate region; other site
391904006978	putative PBP binding loops; other site
391904006979	ABC-ATPase subunit interface; other site
391904006980	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904006981	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904006982	dimer interface [polypeptide binding]; other site
391904006983	conserved gate region; other site
391904006984	putative PBP binding loops; other site
391904006985	ABC-ATPase subunit interface; other site
391904006986	Transcriptional regulators [Transcription]; Region: PurR; COG1609
391904006987	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
391904006988	DNA binding site [nucleotide binding]
391904006989	domain linker motif; other site
391904006990	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
391904006991	ligand binding site [chemical binding]; other site
391904006992	dimerization interface [polypeptide binding]; other site
391904006993	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904006994	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
391904006995	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
391904006996	catalytic core [active]
391904006997	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
391904006998	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
391904006999	dimer interface [polypeptide binding]; other site
391904007000	FMN binding site [chemical binding]; other site
391904007001	NADPH bind site [chemical binding]; other site
391904007002	Predicted membrane protein [Function unknown]; Region: COG1511
391904007003	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
391904007004	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
391904007005	Predicted membrane protein [Function unknown]; Region: COG1511
391904007006	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
391904007007	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
391904007008	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
391904007009	SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent...; Region: SIRT7; cd01410
391904007010	NAD+ binding site [chemical binding]; other site
391904007011	substrate binding site [chemical binding]; other site
391904007012	Zn binding site [ion binding]; other site
391904007013	threonine dehydratase; Provisional; Region: PRK08198
391904007014	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
391904007015	tetramer interface [polypeptide binding]; other site
391904007016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
391904007017	catalytic residue [active]
391904007018	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
391904007019	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
391904007020	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
391904007021	Ca binding site [ion binding]; other site
391904007022	active site
391904007023	catalytic site [active]
391904007024	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
391904007025	Transposase; Region: DDE_Tnp_ISL3; pfam01610
391904007026	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
391904007027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904007028	dimer interface [polypeptide binding]; other site
391904007029	conserved gate region; other site
391904007030	putative PBP binding loops; other site
391904007031	ABC-ATPase subunit interface; other site
391904007032	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
391904007033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
391904007034	dimer interface [polypeptide binding]; other site
391904007035	conserved gate region; other site
391904007036	putative PBP binding loops; other site
391904007037	ABC-ATPase subunit interface; other site
391904007038	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
391904007039	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
391904007040	Transcriptional regulators [Transcription]; Region: MarR; COG1846
391904007041	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
391904007042	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
391904007043	nucleotide binding site [chemical binding]; other site
391904007044	Melibiase; Region: Melibiase; pfam02065
391904007045	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
391904007046	nucleoside/Zn binding site; other site
391904007047	dimer interface [polypeptide binding]; other site
391904007048	catalytic motif [active]
391904007049	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
391904007050	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
391904007051	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
391904007052	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
391904007053	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
391904007054	trimer interface [polypeptide binding]; other site
391904007055	active site
391904007056	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
391904007057	Predicted membrane protein [Function unknown]; Region: COG1511
391904007058	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
391904007059	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
391904007060	active site
391904007061	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
391904007062	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
391904007063	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
391904007064	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
391904007065	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
391904007066	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
391904007067	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
391904007068	HPr interaction site; other site
391904007069	glycerol kinase (GK) interaction site [polypeptide binding]; other site
391904007070	active site
391904007071	phosphorylation site [posttranslational modification]
391904007072	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
391904007073	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
391904007074	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
391904007075	active site turn [active]
391904007076	phosphorylation site [posttranslational modification]
391904007077	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
391904007078	Major Facilitator Superfamily; Region: MFS_1; pfam07690
391904007079	putative substrate translocation pore; other site
391904007080	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
391904007081	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
391904007082	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
391904007083	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
391904007084	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
391904007085	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
391904007086	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
391904007087	Walker A/P-loop; other site
391904007088	ATP binding site [chemical binding]; other site
391904007089	Q-loop/lid; other site
391904007090	ABC transporter signature motif; other site
391904007091	Walker B; other site
391904007092	D-loop; other site
391904007093	H-loop/switch region; other site
391904007094	TOBE domain; Region: TOBE_2; pfam08402
391904007095	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
391904007096	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
391904007097	active site
391904007098	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
391904007099	dimer interface [polypeptide binding]; other site
391904007100	putative radical transfer pathway; other site
391904007101	diiron center [ion binding]; other site
391904007102	tyrosyl radical; other site
391904007103	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
391904007104	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
391904007105	Class I ribonucleotide reductase; Region: RNR_I; cd01679
391904007106	active site
391904007107	dimer interface [polypeptide binding]; other site
391904007108	catalytic residues [active]
391904007109	effector binding site; other site
391904007110	R2 peptide binding site; other site
391904007111	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
391904007112	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
391904007113	catalytic residues [active]
391904007114	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
391904007115	Catalytic domain of Protein Kinases; Region: PKc; cd00180
391904007116	active site
391904007117	ATP binding site [chemical binding]; other site
391904007118	substrate binding site [chemical binding]; other site
391904007119	activation loop (A-loop); other site
391904007120	Gamma interferon inducible lysosomal thiol reductase (GILT); Region: GILT; pfam03227
391904007121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
391904007122	Domain of unknown function (DUF348); Region: DUF348; pfam03990
391904007123	Domain of unknown function (DUF348); Region: DUF348; pfam03990
391904007124	G5 domain; Region: G5; pfam07501
391904007125	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
391904007126	catalytic residue [active]
391904007127	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
391904007128	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
391904007129	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
391904007130	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
391904007131	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
391904007132	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
391904007133	active site
391904007134	NTP binding site [chemical binding]; other site
391904007135	metal binding triad [ion binding]; metal-binding site
391904007136	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
391904007137	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
391904007138	Zn2+ binding site [ion binding]; other site
391904007139	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
391904007140	Mg2+ binding site [ion binding]; other site
391904007141	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
391904007142	active site
391904007143	Ap6A binding site [chemical binding]; other site
391904007144	nudix motif; other site
391904007145	metal binding site [ion binding]; metal-binding site
391904007146	integral membrane protein MviN; Region: mviN; TIGR01695
391904007147	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
391904007148	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
391904007149	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
391904007150	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
391904007151	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
391904007152	ParB-like nuclease domain; Region: ParBc; pfam02195
391904007153	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
391904007154	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
391904007155	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
391904007156	P-loop; other site
391904007157	Magnesium ion binding site [ion binding]; other site
391904007158	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
391904007159	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
391904007160	G-X-X-G motif; other site
391904007161	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
391904007162	RxxxH motif; other site
391904007163	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
391904007164	hypothetical protein; Provisional; Region: PRK14372
391904007165	Ribonuclease P; Region: Ribonuclease_P; pfam00825