-- dump date 20140619_003105 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1254439000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1254439000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439000003 Walker A motif; other site 1254439000004 ATP binding site [chemical binding]; other site 1254439000005 Walker B motif; other site 1254439000006 arginine finger; other site 1254439000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1254439000008 DnaA box-binding interface [nucleotide binding]; other site 1254439000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1254439000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1254439000011 putative DNA binding surface [nucleotide binding]; other site 1254439000012 dimer interface [polypeptide binding]; other site 1254439000013 beta-clamp/clamp loader binding surface; other site 1254439000014 beta-clamp/translesion DNA polymerase binding surface; other site 1254439000015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439000016 Walker A/P-loop; other site 1254439000017 ATP binding site [chemical binding]; other site 1254439000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439000019 Q-loop/lid; other site 1254439000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439000021 ABC transporter signature motif; other site 1254439000022 Walker B; other site 1254439000023 D-loop; other site 1254439000024 H-loop/switch region; other site 1254439000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1254439000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1254439000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1254439000028 Mg2+ binding site [ion binding]; other site 1254439000029 G-X-G motif; other site 1254439000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1254439000031 anchoring element; other site 1254439000032 dimer interface [polypeptide binding]; other site 1254439000033 ATP binding site [chemical binding]; other site 1254439000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1254439000035 active site 1254439000036 putative metal-binding site [ion binding]; other site 1254439000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1254439000038 DNA gyrase subunit A; Validated; Region: PRK05560 1254439000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1254439000040 CAP-like domain; other site 1254439000041 active site 1254439000042 primary dimer interface [polypeptide binding]; other site 1254439000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1254439000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1254439000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1254439000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1254439000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1254439000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1254439000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1254439000050 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1254439000051 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1254439000052 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1254439000053 glutamate dehydrogenase; Provisional; Region: PRK09414 1254439000054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1254439000055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1254439000056 NAD(P) binding site [chemical binding]; other site 1254439000057 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1254439000058 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1254439000059 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1254439000060 Protein of unknown function DUF45; Region: DUF45; pfam01863 1254439000061 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1254439000062 Divergent AAA domain; Region: AAA_4; pfam04326 1254439000063 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1254439000064 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1254439000065 Domain of unknown function DUF21; Region: DUF21; pfam01595 1254439000066 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1254439000067 Transporter associated domain; Region: CorC_HlyC; smart01091 1254439000068 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1254439000069 active site clefts [active] 1254439000070 zinc binding site [ion binding]; other site 1254439000071 dimer interface [polypeptide binding]; other site 1254439000072 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1254439000073 peroxiredoxin; Region: AhpC; TIGR03137 1254439000074 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1254439000075 dimer interface [polypeptide binding]; other site 1254439000076 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1254439000077 catalytic triad [active] 1254439000078 peroxidatic and resolving cysteines [active] 1254439000079 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1254439000080 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1254439000081 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1254439000082 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1254439000083 catalytic residue [active] 1254439000084 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1254439000085 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1254439000086 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1254439000087 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1254439000088 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1254439000089 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1254439000090 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1254439000091 trimer interface [polypeptide binding]; other site 1254439000092 active site 1254439000093 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1254439000094 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1254439000095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439000096 homodimer interface [polypeptide binding]; other site 1254439000097 catalytic residue [active] 1254439000098 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1254439000099 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1254439000100 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1254439000101 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1254439000102 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1254439000103 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1254439000104 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1254439000105 phosphopeptide binding site; other site 1254439000106 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1254439000107 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1254439000108 phosphopeptide binding site; other site 1254439000109 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1254439000110 active site 1254439000111 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1254439000112 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1254439000113 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1254439000114 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1254439000115 active site 1254439000116 ATP binding site [chemical binding]; other site 1254439000117 substrate binding site [chemical binding]; other site 1254439000118 activation loop (A-loop); other site 1254439000119 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1254439000120 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1254439000121 active site 1254439000122 ATP binding site [chemical binding]; other site 1254439000123 substrate binding site [chemical binding]; other site 1254439000124 activation loop (A-loop); other site 1254439000125 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1254439000126 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1254439000127 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1254439000128 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1254439000129 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1254439000130 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1254439000131 glutamine binding [chemical binding]; other site 1254439000132 catalytic triad [active] 1254439000133 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1254439000134 active site 1254439000135 catalytic site [active] 1254439000136 Vpu protein; Region: Vpu; pfam00558 1254439000137 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1254439000138 putative septation inhibitor protein; Reviewed; Region: PRK02251 1254439000139 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1254439000140 Rhomboid family; Region: Rhomboid; pfam01694 1254439000141 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1254439000142 homodimer interface [polypeptide binding]; other site 1254439000143 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1254439000144 active site pocket [active] 1254439000145 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1254439000146 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1254439000147 active site 1254439000148 HIGH motif; other site 1254439000149 dimer interface [polypeptide binding]; other site 1254439000150 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1254439000151 KMSKS motif; other site 1254439000152 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1254439000153 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1254439000154 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1254439000155 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1254439000156 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1254439000157 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1254439000158 catalytic residue [active] 1254439000159 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1254439000160 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1254439000161 protein binding site [polypeptide binding]; other site 1254439000162 Peptidase_C39 like family; Region: DUF3335; pfam11814 1254439000163 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1254439000164 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1254439000165 Walker A/P-loop; other site 1254439000166 ATP binding site [chemical binding]; other site 1254439000167 Q-loop/lid; other site 1254439000168 ABC transporter signature motif; other site 1254439000169 Walker B; other site 1254439000170 D-loop; other site 1254439000171 H-loop/switch region; other site 1254439000172 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1254439000173 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1254439000174 Walker A/P-loop; other site 1254439000175 ATP binding site [chemical binding]; other site 1254439000176 Q-loop/lid; other site 1254439000177 ABC transporter signature motif; other site 1254439000178 Walker B; other site 1254439000179 D-loop; other site 1254439000180 H-loop/switch region; other site 1254439000181 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1254439000182 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1254439000183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439000184 dimer interface [polypeptide binding]; other site 1254439000185 conserved gate region; other site 1254439000186 putative PBP binding loops; other site 1254439000187 ABC-ATPase subunit interface; other site 1254439000188 Helix-turn-helix domain; Region: HTH_16; pfam12645 1254439000189 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1254439000190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1254439000191 S-adenosylmethionine binding site [chemical binding]; other site 1254439000192 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1254439000193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1254439000194 non-specific DNA binding site [nucleotide binding]; other site 1254439000195 salt bridge; other site 1254439000196 sequence-specific DNA binding site [nucleotide binding]; other site 1254439000197 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1254439000198 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1254439000199 G1 box; other site 1254439000200 putative GEF interaction site [polypeptide binding]; other site 1254439000201 GTP/Mg2+ binding site [chemical binding]; other site 1254439000202 Switch I region; other site 1254439000203 G2 box; other site 1254439000204 G3 box; other site 1254439000205 Switch II region; other site 1254439000206 G4 box; other site 1254439000207 G5 box; other site 1254439000208 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1254439000209 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1254439000210 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1254439000211 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1254439000212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439000213 dimer interface [polypeptide binding]; other site 1254439000214 conserved gate region; other site 1254439000215 putative PBP binding loops; other site 1254439000216 ABC-ATPase subunit interface; other site 1254439000217 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1254439000218 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1254439000219 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1254439000220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1254439000221 DNA-binding site [nucleotide binding]; DNA binding site 1254439000222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1254439000223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439000224 homodimer interface [polypeptide binding]; other site 1254439000225 catalytic residue [active] 1254439000226 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1254439000227 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1254439000228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1254439000229 active site 1254439000230 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 1254439000231 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1254439000232 predicted active site [active] 1254439000233 catalytic triad [active] 1254439000234 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1254439000235 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1254439000236 active site 1254439000237 multimer interface [polypeptide binding]; other site 1254439000238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439000239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1254439000240 putative substrate translocation pore; other site 1254439000241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439000242 FOG: CBS domain [General function prediction only]; Region: COG0517 1254439000243 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1254439000244 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1254439000245 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1254439000246 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1254439000247 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1254439000248 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1254439000249 synthetase active site [active] 1254439000250 NTP binding site [chemical binding]; other site 1254439000251 metal binding site [ion binding]; metal-binding site 1254439000252 ferredoxin-NADP+ reductase; Region: PLN02852 1254439000253 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1254439000254 heat shock protein HtpX; Provisional; Region: PRK03072 1254439000255 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1254439000256 active site 1254439000257 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1254439000258 active site 1254439000259 catalytic residues [active] 1254439000260 metal binding site [ion binding]; metal-binding site 1254439000261 aromatic amino acid exporter; Provisional; Region: PRK11689 1254439000262 EamA-like transporter family; Region: EamA; pfam00892 1254439000263 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1254439000264 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1254439000265 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1254439000266 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1254439000267 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1254439000268 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1254439000269 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1254439000270 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1254439000271 classical (c) SDRs; Region: SDR_c; cd05233 1254439000272 NAD(P) binding site [chemical binding]; other site 1254439000273 active site 1254439000274 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1254439000275 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1254439000276 active site 1254439000277 intersubunit interface [polypeptide binding]; other site 1254439000278 zinc binding site [ion binding]; other site 1254439000279 Na+ binding site [ion binding]; other site 1254439000280 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1254439000281 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1254439000282 NodB motif; other site 1254439000283 active site 1254439000284 catalytic site [active] 1254439000285 metal binding site [ion binding]; metal-binding site 1254439000286 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1254439000287 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1254439000288 GDP-binding site [chemical binding]; other site 1254439000289 ACT binding site; other site 1254439000290 IMP binding site; other site 1254439000291 CrcB-like protein; Region: CRCB; pfam02537 1254439000292 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1254439000293 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1254439000294 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1254439000295 Cl- selectivity filter; other site 1254439000296 Cl- binding residues [ion binding]; other site 1254439000297 pore gating glutamate residue; other site 1254439000298 dimer interface [polypeptide binding]; other site 1254439000299 H+/Cl- coupling transport residue; other site 1254439000300 TrkA-C domain; Region: TrkA_C; pfam02080 1254439000301 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1254439000302 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1254439000303 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1254439000304 TM-ABC transporter signature motif; other site 1254439000305 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1254439000306 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1254439000307 TM-ABC transporter signature motif; other site 1254439000308 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1254439000309 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1254439000310 Walker A/P-loop; other site 1254439000311 ATP binding site [chemical binding]; other site 1254439000312 Q-loop/lid; other site 1254439000313 ABC transporter signature motif; other site 1254439000314 Walker B; other site 1254439000315 D-loop; other site 1254439000316 H-loop/switch region; other site 1254439000317 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1254439000318 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1254439000319 Walker A/P-loop; other site 1254439000320 ATP binding site [chemical binding]; other site 1254439000321 Q-loop/lid; other site 1254439000322 ABC transporter signature motif; other site 1254439000323 Walker B; other site 1254439000324 D-loop; other site 1254439000325 H-loop/switch region; other site 1254439000326 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1254439000327 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1254439000328 ligand binding site [chemical binding]; other site 1254439000329 CrcB-like protein; Region: CRCB; pfam02537 1254439000330 CrcB-like protein; Region: CRCB; pfam02537 1254439000331 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439000332 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1254439000333 DNA binding site [nucleotide binding] 1254439000334 domain linker motif; other site 1254439000335 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1254439000336 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1254439000337 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1254439000338 putative ion selectivity filter; other site 1254439000339 putative pore gating glutamate residue; other site 1254439000340 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1254439000341 sucrose phosphorylase; Provisional; Region: PRK13840 1254439000342 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1254439000343 active site 1254439000344 homodimer interface [polypeptide binding]; other site 1254439000345 catalytic site [active] 1254439000346 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 1254439000347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439000348 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1254439000349 putative substrate translocation pore; other site 1254439000350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439000351 metabolite-proton symporter; Region: 2A0106; TIGR00883 1254439000352 putative substrate translocation pore; other site 1254439000353 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1254439000354 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1254439000355 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1254439000356 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1254439000357 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439000358 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1254439000359 DNA binding site [nucleotide binding] 1254439000360 domain linker motif; other site 1254439000361 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1254439000362 dimerization interface [polypeptide binding]; other site 1254439000363 ligand binding site [chemical binding]; other site 1254439000364 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1254439000365 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1254439000366 Walker A/P-loop; other site 1254439000367 ATP binding site [chemical binding]; other site 1254439000368 Q-loop/lid; other site 1254439000369 ABC transporter signature motif; other site 1254439000370 Walker B; other site 1254439000371 D-loop; other site 1254439000372 H-loop/switch region; other site 1254439000373 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1254439000374 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1254439000375 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1254439000376 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1254439000377 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1254439000378 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1254439000379 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439000380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1254439000381 DNA binding site [nucleotide binding] 1254439000382 domain linker motif; other site 1254439000383 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1254439000384 ligand binding site [chemical binding]; other site 1254439000385 dimerization interface [polypeptide binding]; other site 1254439000386 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1254439000387 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1254439000388 active site 1254439000389 catalytic site [active] 1254439000390 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1254439000391 HicB family; Region: HicB; pfam05534 1254439000392 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1254439000393 Helix-turn-helix domain; Region: HTH_17; pfam12728 1254439000394 DivIVA domain; Region: DivI1A_domain; TIGR03544 1254439000395 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1254439000396 active site 1254439000397 catalytic site [active] 1254439000398 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1254439000399 metal ion-dependent adhesion site (MIDAS); other site 1254439000400 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1254439000401 domain interaction interfaces [polypeptide binding]; other site 1254439000402 T surface-antigen of pili; Region: FctA; cl16948 1254439000403 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1254439000404 Cna protein B-type domain; Region: Cna_B; pfam05738 1254439000405 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1254439000406 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1254439000407 ThiS interaction site; other site 1254439000408 putative active site [active] 1254439000409 tetramer interface [polypeptide binding]; other site 1254439000410 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 1254439000411 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 1254439000412 putative ATP binding site [chemical binding]; other site 1254439000413 putative substrate interface [chemical binding]; other site 1254439000414 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1254439000415 thiS-thiF/thiG interaction site; other site 1254439000416 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1254439000417 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 1254439000418 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1254439000419 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1254439000420 active site 1254439000421 catalytic tetrad [active] 1254439000422 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1254439000423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439000424 putative substrate translocation pore; other site 1254439000425 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1254439000426 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1254439000427 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1254439000428 Predicted transcriptional regulators [Transcription]; Region: COG1733 1254439000429 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1254439000430 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1254439000431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1254439000432 dimerization interface [polypeptide binding]; other site 1254439000433 putative DNA binding site [nucleotide binding]; other site 1254439000434 putative Zn2+ binding site [ion binding]; other site 1254439000435 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1254439000436 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1254439000437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439000438 Walker A/P-loop; other site 1254439000439 ATP binding site [chemical binding]; other site 1254439000440 Q-loop/lid; other site 1254439000441 ABC transporter signature motif; other site 1254439000442 Walker B; other site 1254439000443 D-loop; other site 1254439000444 H-loop/switch region; other site 1254439000445 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1254439000446 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1254439000447 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1254439000448 Walker A/P-loop; other site 1254439000449 ATP binding site [chemical binding]; other site 1254439000450 Q-loop/lid; other site 1254439000451 ABC transporter signature motif; other site 1254439000452 Walker B; other site 1254439000453 D-loop; other site 1254439000454 H-loop/switch region; other site 1254439000455 Fic family protein [Function unknown]; Region: COG3177 1254439000456 Fic/DOC family; Region: Fic; pfam02661 1254439000457 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1254439000458 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1254439000459 putative ligand binding site [chemical binding]; other site 1254439000460 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1254439000461 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1254439000462 TM-ABC transporter signature motif; other site 1254439000463 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1254439000464 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1254439000465 TM-ABC transporter signature motif; other site 1254439000466 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1254439000467 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1254439000468 Walker A/P-loop; other site 1254439000469 ATP binding site [chemical binding]; other site 1254439000470 Q-loop/lid; other site 1254439000471 ABC transporter signature motif; other site 1254439000472 Walker B; other site 1254439000473 D-loop; other site 1254439000474 H-loop/switch region; other site 1254439000475 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1254439000476 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1254439000477 Walker A/P-loop; other site 1254439000478 ATP binding site [chemical binding]; other site 1254439000479 Q-loop/lid; other site 1254439000480 ABC transporter signature motif; other site 1254439000481 Walker B; other site 1254439000482 D-loop; other site 1254439000483 H-loop/switch region; other site 1254439000484 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1254439000485 putative deacylase active site [active] 1254439000486 MFS/sugar transport protein; Region: MFS_2; pfam13347 1254439000487 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1254439000488 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1254439000489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1254439000490 Predicted membrane protein [Function unknown]; Region: COG1511 1254439000491 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1254439000492 Predicted membrane protein [Function unknown]; Region: COG1511 1254439000493 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1254439000494 Predicted membrane protein [Function unknown]; Region: COG1511 1254439000495 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1254439000496 Predicted membrane protein [Function unknown]; Region: COG1511 1254439000497 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1254439000498 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1254439000499 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1254439000500 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1254439000501 dimer interface [polypeptide binding]; other site 1254439000502 putative radical transfer pathway; other site 1254439000503 diiron center [ion binding]; other site 1254439000504 tyrosyl radical; other site 1254439000505 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1254439000506 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1254439000507 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1254439000508 active site 1254439000509 dimer interface [polypeptide binding]; other site 1254439000510 catalytic residues [active] 1254439000511 effector binding site; other site 1254439000512 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1254439000513 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1254439000514 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1254439000515 catalytic residues [active] 1254439000516 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1254439000517 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1254439000518 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1254439000519 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1254439000520 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1254439000521 putative active site [active] 1254439000522 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1254439000523 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1254439000524 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1254439000525 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1254439000526 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1254439000527 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1254439000528 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1254439000529 Divergent AAA domain; Region: AAA_4; pfam04326 1254439000530 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1254439000531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1254439000532 putative DNA binding site [nucleotide binding]; other site 1254439000533 putative Zn2+ binding site [ion binding]; other site 1254439000534 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1254439000535 catalytic residues [active] 1254439000536 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1254439000537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439000538 dimer interface [polypeptide binding]; other site 1254439000539 conserved gate region; other site 1254439000540 putative PBP binding loops; other site 1254439000541 ABC-ATPase subunit interface; other site 1254439000542 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1254439000543 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1254439000544 substrate binding pocket [chemical binding]; other site 1254439000545 membrane-bound complex binding site; other site 1254439000546 hinge residues; other site 1254439000547 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1254439000548 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1254439000549 Walker A/P-loop; other site 1254439000550 ATP binding site [chemical binding]; other site 1254439000551 Q-loop/lid; other site 1254439000552 ABC transporter signature motif; other site 1254439000553 Walker B; other site 1254439000554 D-loop; other site 1254439000555 H-loop/switch region; other site 1254439000556 Peptidase family C69; Region: Peptidase_C69; pfam03577 1254439000557 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1254439000558 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1254439000559 active site 1254439000560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1254439000561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1254439000562 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1254439000563 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1254439000564 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1254439000565 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1254439000566 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1254439000567 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1254439000568 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1254439000569 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1254439000570 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1254439000571 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1254439000572 metal binding triad; other site 1254439000573 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1254439000574 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1254439000575 replicative DNA helicase; Region: DnaB; TIGR00665 1254439000576 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1254439000577 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1254439000578 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1254439000579 Walker A motif; other site 1254439000580 Walker A motif; other site 1254439000581 ATP binding site [chemical binding]; other site 1254439000582 Walker B motif; other site 1254439000583 DNA binding loops [nucleotide binding] 1254439000584 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1254439000585 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1254439000586 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1254439000587 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1254439000588 catalytic triad [active] 1254439000589 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1254439000590 ABC1 family; Region: ABC1; cl17513 1254439000591 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1254439000592 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1254439000593 active site 1254439000594 catalytic site [active] 1254439000595 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1254439000596 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1254439000597 active site 1254439000598 MULE transposase domain; Region: MULE; pfam10551 1254439000599 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1254439000600 active site 1254439000601 Ap6A binding site [chemical binding]; other site 1254439000602 nudix motif; other site 1254439000603 metal binding site [ion binding]; metal-binding site 1254439000604 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1254439000605 catalytic core [active] 1254439000606 polyphosphate kinase; Provisional; Region: PRK05443 1254439000607 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1254439000608 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1254439000609 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1254439000610 putative domain interface [polypeptide binding]; other site 1254439000611 putative active site [active] 1254439000612 catalytic site [active] 1254439000613 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1254439000614 putative domain interface [polypeptide binding]; other site 1254439000615 putative active site [active] 1254439000616 catalytic site [active] 1254439000617 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1254439000618 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1254439000619 ATP binding site [chemical binding]; other site 1254439000620 Walker B motif; other site 1254439000621 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1254439000622 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1254439000623 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1254439000624 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1254439000625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439000626 Walker A motif; other site 1254439000627 ATP binding site [chemical binding]; other site 1254439000628 Walker B motif; other site 1254439000629 arginine finger; other site 1254439000630 recombination protein RecR; Reviewed; Region: recR; PRK00076 1254439000631 RecR protein; Region: RecR; pfam02132 1254439000632 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1254439000633 putative active site [active] 1254439000634 putative metal-binding site [ion binding]; other site 1254439000635 tetramer interface [polypeptide binding]; other site 1254439000636 aspartate kinase; Reviewed; Region: PRK06635 1254439000637 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1254439000638 putative nucleotide binding site [chemical binding]; other site 1254439000639 putative catalytic residues [active] 1254439000640 putative Mg ion binding site [ion binding]; other site 1254439000641 putative aspartate binding site [chemical binding]; other site 1254439000642 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1254439000643 putative allosteric regulatory site; other site 1254439000644 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1254439000645 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 1254439000646 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1254439000647 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1254439000648 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1254439000649 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1254439000650 active site 1254439000651 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1254439000652 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1254439000653 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1254439000654 dimer interface [polypeptide binding]; other site 1254439000655 ssDNA binding site [nucleotide binding]; other site 1254439000656 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1254439000657 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1254439000658 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1254439000659 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1254439000660 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1254439000661 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1254439000662 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1254439000663 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1254439000664 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1254439000665 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1254439000666 Walker A/P-loop; other site 1254439000667 ATP binding site [chemical binding]; other site 1254439000668 Q-loop/lid; other site 1254439000669 ABC transporter signature motif; other site 1254439000670 Walker B; other site 1254439000671 D-loop; other site 1254439000672 H-loop/switch region; other site 1254439000673 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1254439000674 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1254439000675 FtsX-like permease family; Region: FtsX; pfam02687 1254439000676 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1254439000677 PAP2 superfamily; Region: PAP2; pfam01569 1254439000678 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1254439000679 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1254439000680 active site 1254439000681 interdomain interaction site; other site 1254439000682 putative metal-binding site [ion binding]; other site 1254439000683 nucleotide binding site [chemical binding]; other site 1254439000684 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1254439000685 domain I; other site 1254439000686 DNA binding groove [nucleotide binding] 1254439000687 phosphate binding site [ion binding]; other site 1254439000688 domain II; other site 1254439000689 domain III; other site 1254439000690 nucleotide binding site [chemical binding]; other site 1254439000691 catalytic site [active] 1254439000692 domain IV; other site 1254439000693 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1254439000694 thymidylate kinase; Validated; Region: tmk; PRK00698 1254439000695 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1254439000696 TMP-binding site; other site 1254439000697 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1254439000698 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1254439000699 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1254439000700 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439000701 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1254439000702 DNA binding site [nucleotide binding] 1254439000703 domain linker motif; other site 1254439000704 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1254439000705 dimerization interface [polypeptide binding]; other site 1254439000706 ligand binding site [chemical binding]; other site 1254439000707 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1254439000708 dimerization domain swap beta strand [polypeptide binding]; other site 1254439000709 regulatory protein interface [polypeptide binding]; other site 1254439000710 active site 1254439000711 regulatory phosphorylation site [posttranslational modification]; other site 1254439000712 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1254439000713 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1254439000714 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1254439000715 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1254439000716 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1254439000717 substrate binding site [chemical binding]; other site 1254439000718 Peptidase family C69; Region: Peptidase_C69; pfam03577 1254439000719 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 1254439000720 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1254439000721 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1254439000722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439000723 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1254439000724 Walker A motif; other site 1254439000725 Walker A/P-loop; other site 1254439000726 ATP binding site [chemical binding]; other site 1254439000727 ATP binding site [chemical binding]; other site 1254439000728 Walker B motif; other site 1254439000729 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 1254439000730 Predicted membrane protein [Function unknown]; Region: COG2246 1254439000731 GtrA-like protein; Region: GtrA; pfam04138 1254439000732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439000733 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1254439000734 catalytic core [active] 1254439000735 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1254439000736 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1254439000737 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1254439000738 active site 1254439000739 HIGH motif; other site 1254439000740 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1254439000741 active site 1254439000742 KMSKS motif; other site 1254439000743 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 1254439000744 putative active site [active] 1254439000745 putative metal binding site [ion binding]; other site 1254439000746 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1254439000747 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1254439000748 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1254439000749 Bacterial transcriptional regulator; Region: IclR; pfam01614 1254439000750 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1254439000751 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1254439000752 substrate binding site [chemical binding]; other site 1254439000753 ligand binding site [chemical binding]; other site 1254439000754 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1254439000755 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1254439000756 substrate binding site [chemical binding]; other site 1254439000757 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1254439000758 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 1254439000759 active site 1254439000760 FMN binding site [chemical binding]; other site 1254439000761 substrate binding site [chemical binding]; other site 1254439000762 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1254439000763 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1254439000764 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1254439000765 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1254439000766 hinge; other site 1254439000767 active site 1254439000768 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1254439000769 Double zinc ribbon; Region: DZR; pfam12773 1254439000770 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1254439000771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439000772 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1254439000773 active site 1254439000774 motif I; other site 1254439000775 motif II; other site 1254439000776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439000777 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1254439000778 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1254439000779 putative acyl-acceptor binding pocket; other site 1254439000780 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1254439000781 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1254439000782 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1254439000783 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1254439000784 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1254439000785 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1254439000786 CAAX protease self-immunity; Region: Abi; pfam02517 1254439000787 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1254439000788 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1254439000789 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 1254439000790 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 1254439000791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1254439000792 Predicted membrane protein [Function unknown]; Region: COG4905 1254439000793 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1254439000794 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1254439000795 Aspartase; Region: Aspartase; cd01357 1254439000796 active sites [active] 1254439000797 tetramer interface [polypeptide binding]; other site 1254439000798 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1254439000799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439000800 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1254439000801 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1254439000802 substrate binding site [chemical binding]; other site 1254439000803 ATP binding site [chemical binding]; other site 1254439000804 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1254439000805 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1254439000806 ssDNA binding site; other site 1254439000807 generic binding surface II; other site 1254439000808 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1254439000809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1254439000810 ATP binding site [chemical binding]; other site 1254439000811 putative Mg++ binding site [ion binding]; other site 1254439000812 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1254439000813 nucleotide binding region [chemical binding]; other site 1254439000814 ATP-binding site [chemical binding]; other site 1254439000815 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1254439000816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1254439000817 S-adenosylmethionine binding site [chemical binding]; other site 1254439000818 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1254439000819 dimer interface [polypeptide binding]; other site 1254439000820 FMN binding site [chemical binding]; other site 1254439000821 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1254439000822 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1254439000823 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1254439000824 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1254439000825 RimM N-terminal domain; Region: RimM; pfam01782 1254439000826 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1254439000827 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1254439000828 G-X-X-G motif; other site 1254439000829 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1254439000830 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1254439000831 putative catalytic site [active] 1254439000832 putative metal binding site [ion binding]; other site 1254439000833 putative phosphate binding site [ion binding]; other site 1254439000834 signal recognition particle protein; Provisional; Region: PRK10867 1254439000835 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1254439000836 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1254439000837 P loop; other site 1254439000838 GTP binding site [chemical binding]; other site 1254439000839 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1254439000840 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1254439000841 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1254439000842 active site 1254439000843 HIGH motif; other site 1254439000844 nucleotide binding site [chemical binding]; other site 1254439000845 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1254439000846 KMSKS motif; other site 1254439000847 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1254439000848 tRNA binding surface [nucleotide binding]; other site 1254439000849 anticodon binding site; other site 1254439000850 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1254439000851 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1254439000852 catalytic triad [active] 1254439000853 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1254439000854 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1254439000855 ABC transporter; Region: ABC_tran_2; pfam12848 1254439000856 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1254439000857 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1254439000858 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1254439000859 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1254439000860 putative valine binding site [chemical binding]; other site 1254439000861 dimer interface [polypeptide binding]; other site 1254439000862 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1254439000863 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1254439000864 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1254439000865 PYR/PP interface [polypeptide binding]; other site 1254439000866 dimer interface [polypeptide binding]; other site 1254439000867 TPP binding site [chemical binding]; other site 1254439000868 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1254439000869 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1254439000870 TPP-binding site [chemical binding]; other site 1254439000871 dimer interface [polypeptide binding]; other site 1254439000872 ribonuclease III; Reviewed; Region: rnc; PRK00102 1254439000873 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1254439000874 dimerization interface [polypeptide binding]; other site 1254439000875 active site 1254439000876 metal binding site [ion binding]; metal-binding site 1254439000877 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1254439000878 dsRNA binding site [nucleotide binding]; other site 1254439000879 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1254439000880 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1254439000881 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1254439000882 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1254439000883 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1254439000884 active site 1254439000885 (T/H)XGH motif; other site 1254439000886 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1254439000887 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1254439000888 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1254439000889 active site 1254439000890 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1254439000891 ribonuclease PH; Reviewed; Region: rph; PRK00173 1254439000892 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1254439000893 hexamer interface [polypeptide binding]; other site 1254439000894 active site 1254439000895 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1254439000896 active site 1254439000897 dimerization interface [polypeptide binding]; other site 1254439000898 Membrane transport protein; Region: Mem_trans; cl09117 1254439000899 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1254439000900 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1254439000901 Substrate binding site; other site 1254439000902 Cupin domain; Region: Cupin_2; cl17218 1254439000903 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1254439000904 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1254439000905 active site 1254439000906 dimer interface [polypeptide binding]; other site 1254439000907 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1254439000908 dimer interface [polypeptide binding]; other site 1254439000909 active site 1254439000910 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1254439000911 HTH-like domain; Region: HTH_21; pfam13276 1254439000912 Integrase core domain; Region: rve; pfam00665 1254439000913 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 1254439000914 active site 1254439000915 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1254439000916 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1254439000917 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1254439000918 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1254439000919 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1254439000920 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1254439000921 Catalytic site [active] 1254439000922 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1254439000923 RNA/DNA hybrid binding site [nucleotide binding]; other site 1254439000924 active site 1254439000925 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439000926 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1254439000927 DNA binding site [nucleotide binding] 1254439000928 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1254439000929 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1254439000930 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1254439000931 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439000932 Walker A/P-loop; other site 1254439000933 ATP binding site [chemical binding]; other site 1254439000934 Q-loop/lid; other site 1254439000935 ABC transporter signature motif; other site 1254439000936 Walker B; other site 1254439000937 D-loop; other site 1254439000938 H-loop/switch region; other site 1254439000939 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1254439000940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439000941 Walker A/P-loop; other site 1254439000942 ATP binding site [chemical binding]; other site 1254439000943 Q-loop/lid; other site 1254439000944 ABC transporter signature motif; other site 1254439000945 Walker B; other site 1254439000946 D-loop; other site 1254439000947 H-loop/switch region; other site 1254439000948 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1254439000949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1254439000950 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1254439000951 NAD(P) binding site [chemical binding]; other site 1254439000952 active site 1254439000953 hypothetical protein; Provisional; Region: PRK06062 1254439000954 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1254439000955 inhibitor-cofactor binding pocket; inhibition site 1254439000956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439000957 catalytic residue [active] 1254439000958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1254439000959 DNA-binding site [nucleotide binding]; DNA binding site 1254439000960 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1254439000961 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1254439000962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439000963 homodimer interface [polypeptide binding]; other site 1254439000964 catalytic residue [active] 1254439000965 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1254439000966 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 1254439000967 ligand binding site [chemical binding]; other site 1254439000968 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1254439000969 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1254439000970 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1254439000971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439000972 putative substrate translocation pore; other site 1254439000973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439000974 potential frameshift: common BLAST hit: gi|322688551|ref|YP_004208285.1| galactosyl transferase CpsD 1254439000975 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1254439000976 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1254439000977 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1254439000978 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1254439000979 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1254439000980 active site 1254439000981 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 1254439000982 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1254439000983 putative catalytic site [active] 1254439000984 putative phosphate binding site [ion binding]; other site 1254439000985 putative metal binding site [ion binding]; other site 1254439000986 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1254439000987 active site 1254439000988 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1254439000989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1254439000990 active site 1254439000991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1254439000992 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1254439000993 putative ADP-binding pocket [chemical binding]; other site 1254439000994 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1254439000995 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1254439000996 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1254439000997 MULE transposase domain; Region: MULE; pfam10551 1254439000998 potential frameshift: common BLAST hit: gi|119025897|ref|YP_909742.1| insertion element membrane protein 1254439000999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1254439001000 transposase/IS protein; Provisional; Region: PRK09183 1254439001001 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1254439001002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1254439001003 DNA-binding interface [nucleotide binding]; DNA binding site 1254439001004 Integrase core domain; Region: rve; pfam00665 1254439001005 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1254439001006 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1254439001007 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1254439001008 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1254439001009 FMN binding site [chemical binding]; other site 1254439001010 dimer interface [polypeptide binding]; other site 1254439001011 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1254439001012 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1254439001013 serine O-acetyltransferase; Region: cysE; TIGR01172 1254439001014 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1254439001015 trimer interface [polypeptide binding]; other site 1254439001016 active site 1254439001017 substrate binding site [chemical binding]; other site 1254439001018 CoA binding site [chemical binding]; other site 1254439001019 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1254439001020 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1254439001021 inhibitor-cofactor binding pocket; inhibition site 1254439001022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439001023 catalytic residue [active] 1254439001024 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1254439001025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1254439001026 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1254439001027 putative dimerization interface [polypeptide binding]; other site 1254439001028 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1254439001029 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1254439001030 ligand binding site [chemical binding]; other site 1254439001031 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1254439001032 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1254439001033 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1254439001034 NAD binding site [chemical binding]; other site 1254439001035 substrate binding site [chemical binding]; other site 1254439001036 homodimer interface [polypeptide binding]; other site 1254439001037 active site 1254439001038 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1254439001039 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1254439001040 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1254439001041 NADP binding site [chemical binding]; other site 1254439001042 active site 1254439001043 putative substrate binding site [chemical binding]; other site 1254439001044 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1254439001045 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1254439001046 substrate binding site; other site 1254439001047 tetramer interface; other site 1254439001048 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 1254439001049 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1254439001050 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1254439001051 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1254439001052 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1254439001053 active site 1254439001054 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1254439001055 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1254439001056 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1254439001057 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1254439001058 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1254439001059 Ligand binding site; other site 1254439001060 Putative Catalytic site; other site 1254439001061 DXD motif; other site 1254439001062 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1254439001063 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1254439001064 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1254439001065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1254439001066 active site 1254439001067 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1254439001068 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1254439001069 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1254439001070 Ligand binding site; other site 1254439001071 metal-binding site 1254439001072 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1254439001073 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1254439001074 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1254439001075 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1254439001076 Walker A/P-loop; other site 1254439001077 ATP binding site [chemical binding]; other site 1254439001078 Q-loop/lid; other site 1254439001079 ABC transporter signature motif; other site 1254439001080 Walker B; other site 1254439001081 D-loop; other site 1254439001082 H-loop/switch region; other site 1254439001083 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1254439001084 active site 1254439001085 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1254439001086 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1254439001087 Probable Catalytic site; other site 1254439001088 metal-binding site 1254439001089 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1254439001090 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1254439001091 active site 1254439001092 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1254439001093 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1254439001094 active site 1254439001095 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1254439001096 Sulfatase; Region: Sulfatase; pfam00884 1254439001097 Chain length determinant protein; Region: Wzz; cl15801 1254439001098 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1254439001099 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1254439001100 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 1254439001101 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1254439001102 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1254439001103 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1254439001104 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1254439001105 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1254439001106 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1254439001107 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1254439001108 active site 1254439001109 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1254439001110 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1254439001111 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1254439001112 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1254439001113 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1254439001114 active site 1254439001115 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1254439001116 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1254439001117 NlpC/P60 family; Region: NLPC_P60; cl17555 1254439001118 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1254439001119 active site 1254439001120 catalytic residues [active] 1254439001121 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 1254439001122 active site 1254439001123 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1254439001124 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1254439001125 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1254439001126 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1254439001127 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1254439001128 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1254439001129 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1254439001130 Cysteine-rich secretory protein family; Region: CAP; pfam00188 1254439001131 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1254439001132 G5 domain; Region: G5; pfam07501 1254439001133 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1254439001134 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1254439001135 catalytic residue [active] 1254439001136 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1254439001137 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1254439001138 catalytic residues [active] 1254439001139 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1254439001140 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1254439001141 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1254439001142 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1254439001143 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1254439001144 putative NADH binding site [chemical binding]; other site 1254439001145 putative active site [active] 1254439001146 nudix motif; other site 1254439001147 putative metal binding site [ion binding]; other site 1254439001148 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1254439001149 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1254439001150 lipoyl attachment site [posttranslational modification]; other site 1254439001151 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1254439001152 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1254439001153 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1254439001154 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1254439001155 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1254439001156 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1254439001157 tartrate dehydrogenase; Region: TTC; TIGR02089 1254439001158 TM2 domain; Region: TM2; pfam05154 1254439001159 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1254439001160 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1254439001161 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1254439001162 ligand binding site [chemical binding]; other site 1254439001163 flexible hinge region; other site 1254439001164 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1254439001165 putative switch regulator; other site 1254439001166 non-specific DNA interactions [nucleotide binding]; other site 1254439001167 DNA binding site [nucleotide binding] 1254439001168 sequence specific DNA binding site [nucleotide binding]; other site 1254439001169 putative cAMP binding site [chemical binding]; other site 1254439001170 Transglycosylase; Region: Transgly; pfam00912 1254439001171 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1254439001172 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1254439001173 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1254439001174 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1254439001175 active site 1254439001176 FMN binding site [chemical binding]; other site 1254439001177 substrate binding site [chemical binding]; other site 1254439001178 homotetramer interface [polypeptide binding]; other site 1254439001179 catalytic residue [active] 1254439001180 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1254439001181 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1254439001182 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1254439001183 Protein of unknown function DUF58; Region: DUF58; pfam01882 1254439001184 MoxR-like ATPases [General function prediction only]; Region: COG0714 1254439001185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439001186 Walker A motif; other site 1254439001187 ATP binding site [chemical binding]; other site 1254439001188 Walker B motif; other site 1254439001189 arginine finger; other site 1254439001190 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1254439001191 Interdomain contacts; other site 1254439001192 Cytokine receptor motif; other site 1254439001193 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1254439001194 Interdomain contacts; other site 1254439001195 Cytokine receptor motif; other site 1254439001196 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1254439001197 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1254439001198 active site 1254439001199 ATP binding site [chemical binding]; other site 1254439001200 substrate binding site [chemical binding]; other site 1254439001201 activation loop (A-loop); other site 1254439001202 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1254439001203 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1254439001204 quinone interaction residues [chemical binding]; other site 1254439001205 active site 1254439001206 catalytic residues [active] 1254439001207 FMN binding site [chemical binding]; other site 1254439001208 substrate binding site [chemical binding]; other site 1254439001209 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1254439001210 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1254439001211 Ligand binding site; other site 1254439001212 Putative Catalytic site; other site 1254439001213 DXD motif; other site 1254439001214 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1254439001215 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1254439001216 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1254439001217 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1254439001218 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1254439001219 dimer interface [polypeptide binding]; other site 1254439001220 active site 1254439001221 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1254439001222 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1254439001223 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1254439001224 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1254439001225 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1254439001226 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1254439001227 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1254439001228 metal ion-dependent adhesion site (MIDAS); other site 1254439001229 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 1254439001230 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1254439001231 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1254439001232 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1254439001233 helix-hairpin-helix signature motif; other site 1254439001234 substrate binding pocket [chemical binding]; other site 1254439001235 active site 1254439001236 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1254439001237 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1254439001238 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1254439001239 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1254439001240 RPB1 interaction site [polypeptide binding]; other site 1254439001241 RPB10 interaction site [polypeptide binding]; other site 1254439001242 RPB11 interaction site [polypeptide binding]; other site 1254439001243 RPB3 interaction site [polypeptide binding]; other site 1254439001244 RPB12 interaction site [polypeptide binding]; other site 1254439001245 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1254439001246 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1254439001247 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1254439001248 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1254439001249 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1254439001250 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1254439001251 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1254439001252 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1254439001253 DNA binding site [nucleotide binding] 1254439001254 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1254439001255 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1254439001256 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1254439001257 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1254439001258 active site 1254439001259 catalytic site [active] 1254439001260 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1254439001261 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1254439001262 Part of AAA domain; Region: AAA_19; pfam13245 1254439001263 Family description; Region: UvrD_C_2; pfam13538 1254439001264 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1254439001265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1254439001266 Coenzyme A binding pocket [chemical binding]; other site 1254439001267 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1254439001268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439001269 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1254439001270 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1254439001271 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1254439001272 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1254439001273 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1254439001274 dimer interface [polypeptide binding]; other site 1254439001275 active site 1254439001276 catalytic residue [active] 1254439001277 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1254439001278 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1254439001279 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1254439001280 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1254439001281 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1254439001282 Zn binding site [ion binding]; other site 1254439001283 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1254439001284 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1254439001285 non-specific DNA binding site [nucleotide binding]; other site 1254439001286 salt bridge; other site 1254439001287 sequence-specific DNA binding site [nucleotide binding]; other site 1254439001288 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1254439001289 active site 1254439001290 NTP binding site [chemical binding]; other site 1254439001291 metal binding triad [ion binding]; metal-binding site 1254439001292 antibiotic binding site [chemical binding]; other site 1254439001293 Protein of unknown function DUF86; Region: DUF86; cl01031 1254439001294 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1254439001295 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1254439001296 inhibitor-cofactor binding pocket; inhibition site 1254439001297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439001298 catalytic residue [active] 1254439001299 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1254439001300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1254439001301 Coenzyme A binding pocket [chemical binding]; other site 1254439001302 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1254439001303 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1254439001304 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 1254439001305 putative active site [active] 1254439001306 metal binding site [ion binding]; metal-binding site 1254439001307 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1254439001308 MULE transposase domain; Region: MULE; pfam10551 1254439001309 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1254439001310 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1254439001311 active site 1254439001312 substrate binding site [chemical binding]; other site 1254439001313 metal binding site [ion binding]; metal-binding site 1254439001314 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1254439001315 active site 1254439001316 catalytic residues [active] 1254439001317 metal binding site [ion binding]; metal-binding site 1254439001318 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1254439001319 putative catalytic site [active] 1254439001320 putative metal binding site [ion binding]; other site 1254439001321 putative phosphate binding site [ion binding]; other site 1254439001322 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1254439001323 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1254439001324 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1254439001325 generic binding surface II; other site 1254439001326 generic binding surface I; other site 1254439001327 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1254439001328 ATP cone domain; Region: ATP-cone; pfam03477 1254439001329 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1254439001330 effector binding site; other site 1254439001331 active site 1254439001332 Zn binding site [ion binding]; other site 1254439001333 glycine loop; other site 1254439001334 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1254439001335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1254439001336 FeS/SAM binding site; other site 1254439001337 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1254439001338 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1254439001339 nucleotide binding site [chemical binding]; other site 1254439001340 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1254439001341 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1254439001342 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1254439001343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1254439001344 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1254439001345 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1254439001346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1254439001347 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1254439001348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1254439001349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1254439001350 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1254439001351 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1254439001352 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1254439001353 MarR family; Region: MarR_2; pfam12802 1254439001354 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1254439001355 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1254439001356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1254439001357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439001358 Walker A/P-loop; other site 1254439001359 ATP binding site [chemical binding]; other site 1254439001360 Q-loop/lid; other site 1254439001361 ABC transporter signature motif; other site 1254439001362 Walker B; other site 1254439001363 D-loop; other site 1254439001364 H-loop/switch region; other site 1254439001365 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1254439001366 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1254439001367 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1254439001368 Walker A/P-loop; other site 1254439001369 ATP binding site [chemical binding]; other site 1254439001370 Q-loop/lid; other site 1254439001371 ABC transporter signature motif; other site 1254439001372 Walker B; other site 1254439001373 D-loop; other site 1254439001374 H-loop/switch region; other site 1254439001375 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1254439001376 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1254439001377 HIGH motif; other site 1254439001378 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1254439001379 active site 1254439001380 KMSKS motif; other site 1254439001381 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1254439001382 tRNA binding surface [nucleotide binding]; other site 1254439001383 anticodon binding site; other site 1254439001384 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1254439001385 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1254439001386 G1 box; other site 1254439001387 GTP/Mg2+ binding site [chemical binding]; other site 1254439001388 G2 box; other site 1254439001389 Switch I region; other site 1254439001390 G3 box; other site 1254439001391 Switch II region; other site 1254439001392 G4 box; other site 1254439001393 G5 box; other site 1254439001394 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1254439001395 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1254439001396 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1254439001397 hypothetical protein; Provisional; Region: PRK11770 1254439001398 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1254439001399 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1254439001400 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1254439001401 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1254439001402 active site 1254439001403 catalytic tetrad [active] 1254439001404 glycerate kinase; Region: TIGR00045 1254439001405 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1254439001406 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1254439001407 homodimer interface [polypeptide binding]; other site 1254439001408 substrate-cofactor binding pocket; other site 1254439001409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439001410 catalytic residue [active] 1254439001411 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1254439001412 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1254439001413 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1254439001414 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1254439001415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1254439001416 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1254439001417 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1254439001418 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1254439001419 catalytic residue [active] 1254439001420 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1254439001421 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1254439001422 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1254439001423 substrate binding pocket [chemical binding]; other site 1254439001424 membrane-bound complex binding site; other site 1254439001425 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1254439001426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439001427 dimer interface [polypeptide binding]; other site 1254439001428 conserved gate region; other site 1254439001429 putative PBP binding loops; other site 1254439001430 ABC-ATPase subunit interface; other site 1254439001431 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1254439001432 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1254439001433 Walker A/P-loop; other site 1254439001434 ATP binding site [chemical binding]; other site 1254439001435 Q-loop/lid; other site 1254439001436 ABC transporter signature motif; other site 1254439001437 Walker B; other site 1254439001438 D-loop; other site 1254439001439 H-loop/switch region; other site 1254439001440 hypothetical protein; Provisional; Region: PRK07906 1254439001441 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1254439001442 putative metal binding site [ion binding]; other site 1254439001443 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1254439001444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439001445 dimer interface [polypeptide binding]; other site 1254439001446 conserved gate region; other site 1254439001447 ABC-ATPase subunit interface; other site 1254439001448 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1254439001449 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1254439001450 Walker A/P-loop; other site 1254439001451 ATP binding site [chemical binding]; other site 1254439001452 Q-loop/lid; other site 1254439001453 ABC transporter signature motif; other site 1254439001454 Walker B; other site 1254439001455 D-loop; other site 1254439001456 H-loop/switch region; other site 1254439001457 NIL domain; Region: NIL; pfam09383 1254439001458 putative acetyltransferase; Provisional; Region: PRK03624 1254439001459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1254439001460 Coenzyme A binding pocket [chemical binding]; other site 1254439001461 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1254439001462 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1254439001463 homodimer interface [polypeptide binding]; other site 1254439001464 ligand binding site [chemical binding]; other site 1254439001465 NAD binding site [chemical binding]; other site 1254439001466 catalytic site [active] 1254439001467 aspartate aminotransferase; Provisional; Region: PRK05764 1254439001468 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1254439001469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439001470 homodimer interface [polypeptide binding]; other site 1254439001471 catalytic residue [active] 1254439001472 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1254439001473 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1254439001474 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1254439001475 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1254439001476 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1254439001477 active site 1254439001478 nucleophile elbow; other site 1254439001479 glutamate racemase; Provisional; Region: PRK00865 1254439001480 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1254439001481 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1254439001482 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1254439001483 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1254439001484 putative active site [active] 1254439001485 redox center [active] 1254439001486 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1254439001487 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1254439001488 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1254439001489 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1254439001490 Phosphotransferase enzyme family; Region: APH; pfam01636 1254439001491 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1254439001492 substrate binding site [chemical binding]; other site 1254439001493 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1254439001494 Part of AAA domain; Region: AAA_19; pfam13245 1254439001495 Family description; Region: UvrD_C_2; pfam13538 1254439001496 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1254439001497 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 1254439001498 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1254439001499 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1254439001500 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 1254439001501 DivIVA domain; Region: DivI1A_domain; TIGR03544 1254439001502 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1254439001503 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1254439001504 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1254439001505 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1254439001506 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1254439001507 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1254439001508 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1254439001509 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1254439001510 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1254439001511 Recombination protein O N terminal; Region: RecO_N; pfam11967 1254439001512 Recombination protein O C terminal; Region: RecO_C; pfam02565 1254439001513 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 1254439001514 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1254439001515 catalytic residue [active] 1254439001516 putative FPP diphosphate binding site; other site 1254439001517 putative FPP binding hydrophobic cleft; other site 1254439001518 dimer interface [polypeptide binding]; other site 1254439001519 putative IPP diphosphate binding site; other site 1254439001520 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439001521 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1254439001522 DNA binding site [nucleotide binding] 1254439001523 domain linker motif; other site 1254439001524 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1254439001525 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1254439001526 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1254439001527 substrate binding [chemical binding]; other site 1254439001528 active site 1254439001529 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1254439001530 galactoside permease; Reviewed; Region: lacY; PRK09528 1254439001531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439001532 putative substrate translocation pore; other site 1254439001533 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439001534 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1254439001535 DNA binding site [nucleotide binding] 1254439001536 domain linker motif; other site 1254439001537 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1254439001538 putative dimerization interface [polypeptide binding]; other site 1254439001539 putative ligand binding site [chemical binding]; other site 1254439001540 Domain of unknown function DUF77; Region: DUF77; pfam01910 1254439001541 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1254439001542 substrate binding site [chemical binding]; other site 1254439001543 dimer interface [polypeptide binding]; other site 1254439001544 ATP binding site [chemical binding]; other site 1254439001545 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1254439001546 thiamine phosphate binding site [chemical binding]; other site 1254439001547 active site 1254439001548 pyrophosphate binding site [ion binding]; other site 1254439001549 ThiC-associated domain; Region: ThiC-associated; pfam13667 1254439001550 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1254439001551 ThiC family; Region: ThiC; pfam01964 1254439001552 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1254439001553 substrate binding site [chemical binding]; other site 1254439001554 multimerization interface [polypeptide binding]; other site 1254439001555 ATP binding site [chemical binding]; other site 1254439001556 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1254439001557 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1254439001558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439001559 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1254439001560 Walker A motif; other site 1254439001561 Walker A/P-loop; other site 1254439001562 ATP binding site [chemical binding]; other site 1254439001563 ATP binding site [chemical binding]; other site 1254439001564 Walker B motif; other site 1254439001565 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1254439001566 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1254439001567 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1254439001568 Walker A motif; other site 1254439001569 ATP binding site [chemical binding]; other site 1254439001570 Walker B motif; other site 1254439001571 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1254439001572 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1254439001573 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1254439001574 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1254439001575 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1254439001576 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1254439001577 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1254439001578 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1254439001579 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 1254439001580 Cell division protein FtsA; Region: FtsA; pfam14450 1254439001581 Pilus assembly protein, PilO; Region: PilO; cl01234 1254439001582 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1254439001583 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1254439001584 motif 1; other site 1254439001585 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1254439001586 active site 1254439001587 motif 2; other site 1254439001588 motif 3; other site 1254439001589 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1254439001590 anticodon binding site; other site 1254439001591 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1254439001592 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1254439001593 FMN binding site [chemical binding]; other site 1254439001594 active site 1254439001595 catalytic residues [active] 1254439001596 substrate binding site [chemical binding]; other site 1254439001597 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1254439001598 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1254439001599 nucleotide binding site [chemical binding]; other site 1254439001600 SulA interaction site; other site 1254439001601 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1254439001602 YGGT family; Region: YGGT; pfam02325 1254439001603 DivIVA protein; Region: DivIVA; pfam05103 1254439001604 DivIVA domain; Region: DivI1A_domain; TIGR03544 1254439001605 Septum formation initiator; Region: DivIC; cl17659 1254439001606 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1254439001607 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1254439001608 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1254439001609 active site 1254439001610 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1254439001611 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1254439001612 active site 1254439001613 PHP Thumb interface [polypeptide binding]; other site 1254439001614 metal binding site [ion binding]; metal-binding site 1254439001615 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1254439001616 generic binding surface II; other site 1254439001617 generic binding surface I; other site 1254439001618 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1254439001619 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1254439001620 NAD binding site [chemical binding]; other site 1254439001621 dimerization interface [polypeptide binding]; other site 1254439001622 product binding site; other site 1254439001623 substrate binding site [chemical binding]; other site 1254439001624 zinc binding site [ion binding]; other site 1254439001625 catalytic residues [active] 1254439001626 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1254439001627 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1254439001628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439001629 homodimer interface [polypeptide binding]; other site 1254439001630 catalytic residue [active] 1254439001631 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1254439001632 putative active site pocket [active] 1254439001633 4-fold oligomerization interface [polypeptide binding]; other site 1254439001634 metal binding residues [ion binding]; metal-binding site 1254439001635 3-fold/trimer interface [polypeptide binding]; other site 1254439001636 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1254439001637 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1254439001638 putative active site [active] 1254439001639 oxyanion strand; other site 1254439001640 catalytic triad [active] 1254439001641 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1254439001642 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1254439001643 catalytic residues [active] 1254439001644 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1254439001645 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1254439001646 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1254439001647 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1254439001648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1254439001649 ATP binding site [chemical binding]; other site 1254439001650 putative Mg++ binding site [ion binding]; other site 1254439001651 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1254439001652 nucleotide binding region [chemical binding]; other site 1254439001653 ATP-binding site [chemical binding]; other site 1254439001654 Helicase associated domain (HA2); Region: HA2; pfam04408 1254439001655 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1254439001656 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1254439001657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1254439001658 S-adenosylmethionine binding site [chemical binding]; other site 1254439001659 GTPases [General function prediction only]; Region: HflX; COG2262 1254439001660 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1254439001661 HflX GTPase family; Region: HflX; cd01878 1254439001662 G1 box; other site 1254439001663 GTP/Mg2+ binding site [chemical binding]; other site 1254439001664 Switch I region; other site 1254439001665 G2 box; other site 1254439001666 G3 box; other site 1254439001667 Switch II region; other site 1254439001668 G4 box; other site 1254439001669 G5 box; other site 1254439001670 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1254439001671 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1254439001672 NAD binding site [chemical binding]; other site 1254439001673 dimer interface [polypeptide binding]; other site 1254439001674 substrate binding site [chemical binding]; other site 1254439001675 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1254439001676 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1254439001677 LexA repressor; Validated; Region: PRK00215 1254439001678 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1254439001679 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1254439001680 Catalytic site [active] 1254439001681 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1254439001682 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1254439001683 ATP cone domain; Region: ATP-cone; pfam03477 1254439001684 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1254439001685 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1254439001686 ligand binding site [chemical binding]; other site 1254439001687 NAD binding site [chemical binding]; other site 1254439001688 tetramer interface [polypeptide binding]; other site 1254439001689 catalytic site [active] 1254439001690 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1254439001691 L-serine binding site [chemical binding]; other site 1254439001692 ACT domain interface; other site 1254439001693 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1254439001694 Part of AAA domain; Region: AAA_19; pfam13245 1254439001695 Family description; Region: UvrD_C_2; pfam13538 1254439001696 cell division protein MraZ; Reviewed; Region: PRK00326 1254439001697 MraZ protein; Region: MraZ; pfam02381 1254439001698 MraZ protein; Region: MraZ; pfam02381 1254439001699 MraW methylase family; Region: Methyltransf_5; cl17771 1254439001700 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1254439001701 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1254439001702 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1254439001703 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1254439001704 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 1254439001705 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1254439001706 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1254439001707 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1254439001708 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1254439001709 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1254439001710 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1254439001711 Mg++ binding site [ion binding]; other site 1254439001712 putative catalytic motif [active] 1254439001713 putative substrate binding site [chemical binding]; other site 1254439001714 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1254439001715 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1254439001716 cell division protein FtsW; Region: ftsW; TIGR02614 1254439001717 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1254439001718 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1254439001719 active site 1254439001720 homodimer interface [polypeptide binding]; other site 1254439001721 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1254439001722 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1254439001723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1254439001724 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1254439001725 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1254439001726 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1254439001727 Cell division protein FtsQ; Region: FtsQ; pfam03799 1254439001728 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1254439001729 active site 1254439001730 catalytic site [active] 1254439001731 substrate binding site [chemical binding]; other site 1254439001732 Uncharacterized conserved protein [Function unknown]; Region: COG4748 1254439001733 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1254439001734 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1254439001735 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1254439001736 MULE transposase domain; Region: MULE; pfam10551 1254439001737 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1254439001738 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1254439001739 putative active site [active] 1254439001740 dimerization interface [polypeptide binding]; other site 1254439001741 putative tRNAtyr binding site [nucleotide binding]; other site 1254439001742 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1254439001743 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1254439001744 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1254439001745 CRISPR-spacer-1 1254439001746 CRISPR-spacer-2 1254439001747 CRISPR-spacer-3 1254439001748 CRISPR-spacer-4 1254439001749 CRISPR-spacer-5 1254439001750 CRISPR-spacer-6 1254439001751 CRISPR-spacer-7 1254439001752 CRISPR-spacer-8 1254439001753 CRISPR-spacer-9 1254439001754 CRISPR-spacer-10 1254439001755 CRISPR-spacer-11 1254439001756 CRISPR-spacer-12 1254439001757 CRISPR-spacer-13 1254439001758 CRISPR-spacer-14 1254439001759 CRISPR-spacer-15 1254439001760 CRISPR-spacer-16 1254439001761 CRISPR-spacer-17 1254439001762 CRISPR-spacer-18 1254439001763 CRISPR-spacer-19 1254439001764 CRISPR-spacer-20 1254439001765 CRISPR-spacer-21 1254439001766 CRISPR-spacer-22 1254439001767 CRISPR-spacer-23 1254439001768 CRISPR-spacer-24 1254439001769 CRISPR-spacer-25 1254439001770 CRISPR-spacer-26 1254439001771 CRISPR-spacer-27 1254439001772 CRISPR-spacer-28 1254439001773 CRISPR-spacer-29 1254439001774 CRISPR-spacer-30 1254439001775 CRISPR-spacer-31 1254439001776 CRISPR-spacer-32 1254439001777 CRISPR-spacer-33 1254439001778 CRISPR-spacer-34 1254439001779 CRISPR-spacer-35 1254439001780 CRISPR-spacer-36 1254439001781 CRISPR-spacer-37 1254439001782 CRISPR-spacer-38 1254439001783 CRISPR-spacer-39 1254439001784 CRISPR-spacer-40 1254439001785 CRISPR-spacer-41 1254439001786 CRISPR-spacer-42 1254439001787 CRISPR-spacer-43 1254439001788 CRISPR-spacer-44 1254439001789 CRISPR-spacer-45 1254439001790 CRISPR-spacer-46 1254439001791 CRISPR-spacer-47 1254439001792 CRISPR-spacer-48 1254439001793 CRISPR-spacer-49 1254439001794 CRISPR-spacer-50 1254439001795 CRISPR-spacer-51 1254439001796 CRISPR-spacer-52 1254439001797 CRISPR-spacer-53 1254439001798 CRISPR-spacer-54 1254439001799 CRISPR-spacer-55 1254439001800 CRISPR-spacer-56 1254439001801 CRISPR-spacer-57 1254439001802 CRISPR-spacer-58 1254439001803 CRISPR-spacer-59 1254439001804 CRISPR-spacer-60 1254439001805 CRISPR-spacer-61 1254439001806 CRISPR-spacer-62 1254439001807 CRISPR-spacer-63 1254439001808 CRISPR-spacer-64 1254439001809 CRISPR-spacer-65 1254439001810 CRISPR-spacer-66 1254439001811 CRISPR-spacer-67 1254439001812 CRISPR-spacer-68 1254439001813 CRISPR-spacer-69 1254439001814 CRISPR-spacer-70 1254439001815 CRISPR-spacer-71 1254439001816 CRISPR-spacer-72 1254439001817 CRISPR-spacer-73 1254439001818 CRISPR-spacer-74 1254439001819 CRISPR-spacer-75 1254439001820 CRISPR-spacer-76 1254439001821 CRISPR-spacer-77 1254439001822 CRISPR-spacer-78 1254439001823 CRISPR-spacer-79 1254439001824 CRISPR-spacer-80 1254439001825 CRISPR-spacer-81 1254439001826 CRISPR-spacer-82 1254439001827 CRISPR-spacer-83 1254439001828 CRISPR-spacer-84 1254439001829 CRISPR-spacer-85 1254439001830 CRISPR-spacer-86 1254439001831 CRISPR-spacer-87 1254439001832 CRISPR-spacer-88 1254439001833 CRISPR-spacer-89 1254439001834 CRISPR-spacer-90 1254439001835 CRISPR-spacer-91 1254439001836 CRISPR-spacer-92 1254439001837 CRISPR-spacer-93 1254439001838 CRISPR-spacer-94 1254439001839 CRISPR-spacer-95 1254439001840 CRISPR-spacer-96 1254439001841 CRISPR-spacer-97 1254439001842 CRISPR-spacer-98 1254439001843 CRISPR-spacer-99 1254439001844 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1254439001845 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1254439001846 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1254439001847 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1254439001848 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1254439001849 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 1254439001850 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1254439001851 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1254439001852 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1254439001853 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1254439001854 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1254439001855 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1254439001856 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1254439001857 CBD_II domain; Region: CBD_II; smart00637 1254439001858 Cellulose binding domain; Region: CBM_2; pfam00553 1254439001859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439001860 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1254439001861 putative substrate translocation pore; other site 1254439001862 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1254439001863 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1254439001864 putative substrate binding site [chemical binding]; other site 1254439001865 putative ATP binding site [chemical binding]; other site 1254439001866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1254439001867 putative DNA binding site [nucleotide binding]; other site 1254439001868 putative Zn2+ binding site [ion binding]; other site 1254439001869 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1254439001870 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1254439001871 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1254439001872 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1254439001873 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1254439001874 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1254439001875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439001876 dimer interface [polypeptide binding]; other site 1254439001877 conserved gate region; other site 1254439001878 putative PBP binding loops; other site 1254439001879 ABC-ATPase subunit interface; other site 1254439001880 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1254439001881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439001882 dimer interface [polypeptide binding]; other site 1254439001883 conserved gate region; other site 1254439001884 ABC-ATPase subunit interface; other site 1254439001885 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1254439001886 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1254439001887 Walker A/P-loop; other site 1254439001888 ATP binding site [chemical binding]; other site 1254439001889 Q-loop/lid; other site 1254439001890 ABC transporter signature motif; other site 1254439001891 Walker B; other site 1254439001892 D-loop; other site 1254439001893 H-loop/switch region; other site 1254439001894 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1254439001895 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1254439001896 Walker A/P-loop; other site 1254439001897 ATP binding site [chemical binding]; other site 1254439001898 Q-loop/lid; other site 1254439001899 ABC transporter signature motif; other site 1254439001900 Walker B; other site 1254439001901 D-loop; other site 1254439001902 H-loop/switch region; other site 1254439001903 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1254439001904 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1254439001905 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1254439001906 active site 1254439001907 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1254439001908 nudix motif; other site 1254439001909 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1254439001910 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1254439001911 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1254439001912 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1254439001913 AAA domain; Region: AAA_23; pfam13476 1254439001914 Walker A/P-loop; other site 1254439001915 ATP binding site [chemical binding]; other site 1254439001916 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 1254439001917 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1254439001918 ABC transporter signature motif; other site 1254439001919 Walker B; other site 1254439001920 D-loop; other site 1254439001921 H-loop/switch region; other site 1254439001922 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1254439001923 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1254439001924 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1254439001925 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1254439001926 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1254439001927 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1254439001928 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1254439001929 active site 1254439001930 catalytic site [active] 1254439001931 substrate binding site [chemical binding]; other site 1254439001932 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1254439001933 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1254439001934 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1254439001935 DNA binding residues [nucleotide binding] 1254439001936 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1254439001937 active site 1254439001938 catalytic residues [active] 1254439001939 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1254439001940 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1254439001941 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1254439001942 putative deacylase active site [active] 1254439001943 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1254439001944 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1254439001945 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1254439001946 Thiamine pyrophosphokinase; Region: TPK; cd07995 1254439001947 active site 1254439001948 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1254439001949 dimerization interface [polypeptide binding]; other site 1254439001950 thiamine binding site [chemical binding]; other site 1254439001951 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1254439001952 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1254439001953 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1254439001954 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1254439001955 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1254439001956 23S rRNA binding site [nucleotide binding]; other site 1254439001957 L21 binding site [polypeptide binding]; other site 1254439001958 L13 binding site [polypeptide binding]; other site 1254439001959 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1254439001960 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1254439001961 active site 1254439001962 Int/Topo IB signature motif; other site 1254439001963 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1254439001964 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1254439001965 P-loop; other site 1254439001966 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1254439001967 Magnesium ion binding site [ion binding]; other site 1254439001968 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1254439001969 Magnesium ion binding site [ion binding]; other site 1254439001970 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1254439001971 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1254439001972 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1254439001973 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1254439001974 G1 box; other site 1254439001975 putative GEF interaction site [polypeptide binding]; other site 1254439001976 GTP/Mg2+ binding site [chemical binding]; other site 1254439001977 Switch I region; other site 1254439001978 G2 box; other site 1254439001979 G3 box; other site 1254439001980 Switch II region; other site 1254439001981 G4 box; other site 1254439001982 G5 box; other site 1254439001983 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1254439001984 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1254439001985 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1254439001986 Prephenate dehydratase; Region: PDT; pfam00800 1254439001987 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1254439001988 putative L-Phe binding site [chemical binding]; other site 1254439001989 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1254439001990 NAD binding site [chemical binding]; other site 1254439001991 Prephenate dehydrogenase; Region: PDH; pfam02153 1254439001992 prephenate dehydrogenase; Validated; Region: PRK08507 1254439001993 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1254439001994 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1254439001995 active site 1254439001996 DNA binding site [nucleotide binding] 1254439001997 Int/Topo IB signature motif; other site 1254439001998 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1254439001999 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1254439002000 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1254439002001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439002002 dimer interface [polypeptide binding]; other site 1254439002003 conserved gate region; other site 1254439002004 putative PBP binding loops; other site 1254439002005 ABC-ATPase subunit interface; other site 1254439002006 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1254439002007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439002008 dimer interface [polypeptide binding]; other site 1254439002009 conserved gate region; other site 1254439002010 putative PBP binding loops; other site 1254439002011 ABC-ATPase subunit interface; other site 1254439002012 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1254439002013 AAA domain; Region: AAA_21; pfam13304 1254439002014 Walker A/P-loop; other site 1254439002015 ATP binding site [chemical binding]; other site 1254439002016 Q-loop/lid; other site 1254439002017 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1254439002018 ABC transporter signature motif; other site 1254439002019 Walker B; other site 1254439002020 D-loop; other site 1254439002021 H-loop/switch region; other site 1254439002022 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1254439002023 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1254439002024 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1254439002025 Walker A/P-loop; other site 1254439002026 ATP binding site [chemical binding]; other site 1254439002027 Q-loop/lid; other site 1254439002028 ABC transporter signature motif; other site 1254439002029 Walker B; other site 1254439002030 D-loop; other site 1254439002031 H-loop/switch region; other site 1254439002032 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1254439002033 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1254439002034 putative active site [active] 1254439002035 putative catalytic site [active] 1254439002036 putative DNA binding site [nucleotide binding]; other site 1254439002037 putative phosphate binding site [ion binding]; other site 1254439002038 metal binding site A [ion binding]; metal-binding site 1254439002039 putative AP binding site [nucleotide binding]; other site 1254439002040 putative metal binding site B [ion binding]; other site 1254439002041 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1254439002042 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1254439002043 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1254439002044 TRAM domain; Region: TRAM; pfam01938 1254439002045 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1254439002046 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1254439002047 Family description; Region: ACT_7; pfam13840 1254439002048 Predicted membrane protein [Function unknown]; Region: COG2364 1254439002049 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1254439002050 MULE transposase domain; Region: MULE; pfam10551 1254439002051 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1254439002052 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1254439002053 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1254439002054 putative NAD(P) binding site [chemical binding]; other site 1254439002055 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1254439002056 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1254439002057 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1254439002058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1254439002059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1254439002060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1254439002061 dimerization interface [polypeptide binding]; other site 1254439002062 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1254439002063 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1254439002064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439002065 motif II; other site 1254439002066 Membrane transport protein; Region: Mem_trans; cl09117 1254439002067 aconitate hydratase; Validated; Region: PRK09277 1254439002068 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1254439002069 substrate binding site [chemical binding]; other site 1254439002070 ligand binding site [chemical binding]; other site 1254439002071 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1254439002072 substrate binding site [chemical binding]; other site 1254439002073 Protein of unknown function DUF262; Region: DUF262; pfam03235 1254439002074 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1254439002075 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1254439002076 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1254439002077 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1254439002078 EamA-like transporter family; Region: EamA; pfam00892 1254439002079 EamA-like transporter family; Region: EamA; pfam00892 1254439002080 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 1254439002081 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1254439002082 dimer interface [polypeptide binding]; other site 1254439002083 substrate binding site [chemical binding]; other site 1254439002084 ATP binding site [chemical binding]; other site 1254439002085 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1254439002086 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1254439002087 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1254439002088 synthetase active site [active] 1254439002089 NTP binding site [chemical binding]; other site 1254439002090 metal binding site [ion binding]; metal-binding site 1254439002091 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1254439002092 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1254439002093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1254439002094 FeS/SAM binding site; other site 1254439002095 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1254439002096 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1254439002097 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1254439002098 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1254439002099 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1254439002100 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1254439002101 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1254439002102 Competence-damaged protein; Region: CinA; pfam02464 1254439002103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1254439002104 non-specific DNA binding site [nucleotide binding]; other site 1254439002105 salt bridge; other site 1254439002106 sequence-specific DNA binding site [nucleotide binding]; other site 1254439002107 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1254439002108 recombinase A; Provisional; Region: recA; PRK09354 1254439002109 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1254439002110 hexamer interface [polypeptide binding]; other site 1254439002111 Walker A motif; other site 1254439002112 ATP binding site [chemical binding]; other site 1254439002113 Walker B motif; other site 1254439002114 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1254439002115 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1254439002116 30S subunit binding site; other site 1254439002117 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1254439002118 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1254439002119 ATP binding site [chemical binding]; other site 1254439002120 putative Mg++ binding site [ion binding]; other site 1254439002121 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1254439002122 SEC-C motif; Region: SEC-C; pfam02810 1254439002123 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1254439002124 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1254439002125 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1254439002126 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1254439002127 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1254439002128 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1254439002129 putative acyl-acceptor binding pocket; other site 1254439002130 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1254439002131 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1254439002132 active site 1254439002133 ATP binding site [chemical binding]; other site 1254439002134 substrate binding site [chemical binding]; other site 1254439002135 activation loop (A-loop); other site 1254439002136 PASTA domain; Region: PASTA; pfam03793 1254439002137 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1254439002138 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1254439002139 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1254439002140 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1254439002141 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1254439002142 substrate binding pocket [chemical binding]; other site 1254439002143 chain length determination region; other site 1254439002144 substrate-Mg2+ binding site; other site 1254439002145 catalytic residues [active] 1254439002146 aspartate-rich region 1; other site 1254439002147 active site lid residues [active] 1254439002148 aspartate-rich region 2; other site 1254439002149 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1254439002150 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1254439002151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1254439002152 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1254439002153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1254439002154 DNA binding residues [nucleotide binding] 1254439002155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1254439002156 ATP binding site [chemical binding]; other site 1254439002157 Mg2+ binding site [ion binding]; other site 1254439002158 G-X-G motif; other site 1254439002159 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1254439002160 anchoring element; other site 1254439002161 dimer interface [polypeptide binding]; other site 1254439002162 ATP binding site [chemical binding]; other site 1254439002163 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1254439002164 active site 1254439002165 putative metal-binding site [ion binding]; other site 1254439002166 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1254439002167 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1254439002168 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1254439002169 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1254439002170 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1254439002171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1254439002172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1254439002173 salt bridge; other site 1254439002174 non-specific DNA binding site [nucleotide binding]; other site 1254439002175 sequence-specific DNA binding site [nucleotide binding]; other site 1254439002176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439002177 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1254439002178 putative substrate translocation pore; other site 1254439002179 DNA Topoisomerase IV; Region: TOP4c; smart00434 1254439002180 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1254439002181 CAP-like domain; other site 1254439002182 active site 1254439002183 primary dimer interface [polypeptide binding]; other site 1254439002184 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1254439002185 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1254439002186 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1254439002187 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1254439002188 trimer interface [polypeptide binding]; other site 1254439002189 active site 1254439002190 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1254439002191 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1254439002192 Zn2+ binding site [ion binding]; other site 1254439002193 Mg2+ binding site [ion binding]; other site 1254439002194 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1254439002195 synthetase active site [active] 1254439002196 NTP binding site [chemical binding]; other site 1254439002197 metal binding site [ion binding]; metal-binding site 1254439002198 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1254439002199 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1254439002200 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1254439002201 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1254439002202 Walker A/P-loop; other site 1254439002203 ATP binding site [chemical binding]; other site 1254439002204 Q-loop/lid; other site 1254439002205 ABC transporter signature motif; other site 1254439002206 Walker B; other site 1254439002207 D-loop; other site 1254439002208 H-loop/switch region; other site 1254439002209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1254439002210 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 1254439002211 active site 1254439002212 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 1254439002213 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1254439002214 potential frameshift: common BLAST hit: gi|283456258|ref|YP_003360822.1| replicative DNA helicase 1254439002215 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1254439002216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439002217 active site 1254439002218 motif I; other site 1254439002219 motif II; other site 1254439002220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439002221 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1254439002222 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1254439002223 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1254439002224 Walker A/P-loop; other site 1254439002225 ATP binding site [chemical binding]; other site 1254439002226 Q-loop/lid; other site 1254439002227 ABC transporter signature motif; other site 1254439002228 Walker B; other site 1254439002229 D-loop; other site 1254439002230 H-loop/switch region; other site 1254439002231 NIL domain; Region: NIL; cl09633 1254439002232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439002233 ABC-ATPase subunit interface; other site 1254439002234 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1254439002235 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1254439002236 metal binding site [ion binding]; metal-binding site 1254439002237 NAD synthetase; Provisional; Region: PRK13981 1254439002238 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1254439002239 multimer interface [polypeptide binding]; other site 1254439002240 active site 1254439002241 catalytic triad [active] 1254439002242 protein interface 1 [polypeptide binding]; other site 1254439002243 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1254439002244 homodimer interface [polypeptide binding]; other site 1254439002245 NAD binding pocket [chemical binding]; other site 1254439002246 ATP binding pocket [chemical binding]; other site 1254439002247 Mg binding site [ion binding]; other site 1254439002248 active-site loop [active] 1254439002249 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1254439002250 Pyruvate formate lyase 1; Region: PFL1; cd01678 1254439002251 coenzyme A binding site [chemical binding]; other site 1254439002252 active site 1254439002253 catalytic residues [active] 1254439002254 glycine loop; other site 1254439002255 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1254439002256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1254439002257 FeS/SAM binding site; other site 1254439002258 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1254439002259 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1254439002260 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1254439002261 active site 1254439002262 catalytic site [active] 1254439002263 substrate binding site [chemical binding]; other site 1254439002264 HRDC domain; Region: HRDC; pfam00570 1254439002265 trigger factor; Provisional; Region: tig; PRK01490 1254439002266 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1254439002267 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1254439002268 Clp protease; Region: CLP_protease; pfam00574 1254439002269 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1254439002270 oligomer interface [polypeptide binding]; other site 1254439002271 active site residues [active] 1254439002272 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1254439002273 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1254439002274 oligomer interface [polypeptide binding]; other site 1254439002275 active site residues [active] 1254439002276 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1254439002277 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1254439002278 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1254439002279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439002280 Walker A motif; other site 1254439002281 ATP binding site [chemical binding]; other site 1254439002282 Walker B motif; other site 1254439002283 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1254439002284 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1254439002285 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1254439002286 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1254439002287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1254439002288 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1254439002289 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1254439002290 catalytic loop [active] 1254439002291 iron binding site [ion binding]; other site 1254439002292 L-aspartate oxidase; Provisional; Region: PRK06175 1254439002293 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1254439002294 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1254439002295 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1254439002296 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1254439002297 DNA binding site [nucleotide binding] 1254439002298 active site 1254439002299 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1254439002300 DNA protecting protein DprA; Region: dprA; TIGR00732 1254439002301 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1254439002302 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1254439002303 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1254439002304 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1254439002305 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1254439002306 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1254439002307 dimer interface [polypeptide binding]; other site 1254439002308 pyridoxal binding site [chemical binding]; other site 1254439002309 ATP binding site [chemical binding]; other site 1254439002310 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1254439002311 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1254439002312 homodimer interface [polypeptide binding]; other site 1254439002313 substrate-cofactor binding pocket; other site 1254439002314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439002315 catalytic residue [active] 1254439002316 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1254439002317 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1254439002318 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1254439002319 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1254439002320 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1254439002321 Walker A/P-loop; other site 1254439002322 ATP binding site [chemical binding]; other site 1254439002323 Q-loop/lid; other site 1254439002324 ABC transporter signature motif; other site 1254439002325 Walker B; other site 1254439002326 D-loop; other site 1254439002327 H-loop/switch region; other site 1254439002328 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1254439002329 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1254439002330 Walker A/P-loop; other site 1254439002331 ATP binding site [chemical binding]; other site 1254439002332 Q-loop/lid; other site 1254439002333 ABC transporter signature motif; other site 1254439002334 Walker B; other site 1254439002335 D-loop; other site 1254439002336 H-loop/switch region; other site 1254439002337 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1254439002338 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1254439002339 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1254439002340 Walker A/P-loop; other site 1254439002341 ATP binding site [chemical binding]; other site 1254439002342 Q-loop/lid; other site 1254439002343 ABC transporter signature motif; other site 1254439002344 Walker B; other site 1254439002345 D-loop; other site 1254439002346 H-loop/switch region; other site 1254439002347 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1254439002348 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1254439002349 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1254439002350 FtsX-like permease family; Region: FtsX; pfam02687 1254439002351 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1254439002352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1254439002353 active site 1254439002354 phosphorylation site [posttranslational modification] 1254439002355 intermolecular recognition site; other site 1254439002356 dimerization interface [polypeptide binding]; other site 1254439002357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1254439002358 DNA binding residues [nucleotide binding] 1254439002359 dimerization interface [polypeptide binding]; other site 1254439002360 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1254439002361 Histidine kinase; Region: HisKA_3; pfam07730 1254439002362 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1254439002363 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1254439002364 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1254439002365 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1254439002366 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1254439002367 classical (c) SDRs; Region: SDR_c; cd05233 1254439002368 active site 1254439002369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1254439002370 GTP-binding protein YchF; Reviewed; Region: PRK09601 1254439002371 YchF GTPase; Region: YchF; cd01900 1254439002372 G1 box; other site 1254439002373 GTP/Mg2+ binding site [chemical binding]; other site 1254439002374 Switch I region; other site 1254439002375 G2 box; other site 1254439002376 Switch II region; other site 1254439002377 G3 box; other site 1254439002378 G4 box; other site 1254439002379 G5 box; other site 1254439002380 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1254439002381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1254439002382 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1254439002383 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1254439002384 catalytic core [active] 1254439002385 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1254439002386 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1254439002387 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1254439002388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439002389 Walker A/P-loop; other site 1254439002390 ATP binding site [chemical binding]; other site 1254439002391 Q-loop/lid; other site 1254439002392 ABC transporter signature motif; other site 1254439002393 Walker B; other site 1254439002394 D-loop; other site 1254439002395 H-loop/switch region; other site 1254439002396 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1254439002397 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1254439002398 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1254439002399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439002400 dimer interface [polypeptide binding]; other site 1254439002401 conserved gate region; other site 1254439002402 putative PBP binding loops; other site 1254439002403 ABC-ATPase subunit interface; other site 1254439002404 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 1254439002405 NMT1/THI5 like; Region: NMT1; pfam09084 1254439002406 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1254439002407 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 1254439002408 active site 1254439002409 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1254439002410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1254439002411 Coenzyme A binding pocket [chemical binding]; other site 1254439002412 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1254439002413 putative active site [active] 1254439002414 catalytic residue [active] 1254439002415 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1254439002416 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1254439002417 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1254439002418 ATP binding site [chemical binding]; other site 1254439002419 putative Mg++ binding site [ion binding]; other site 1254439002420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1254439002421 nucleotide binding region [chemical binding]; other site 1254439002422 ATP-binding site [chemical binding]; other site 1254439002423 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1254439002424 enolase; Provisional; Region: eno; PRK00077 1254439002425 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1254439002426 dimer interface [polypeptide binding]; other site 1254439002427 metal binding site [ion binding]; metal-binding site 1254439002428 substrate binding pocket [chemical binding]; other site 1254439002429 Septum formation initiator; Region: DivIC; pfam04977 1254439002430 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1254439002431 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1254439002432 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1254439002433 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1254439002434 RDD family; Region: RDD; pfam06271 1254439002435 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1254439002436 Winged helix-turn helix; Region: HTH_29; pfam13551 1254439002437 DNA-binding interface [nucleotide binding]; DNA binding site 1254439002438 Integrase core domain; Region: rve; pfam00665 1254439002439 transposase/IS protein; Provisional; Region: PRK09183 1254439002440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439002441 Walker A motif; other site 1254439002442 ATP binding site [chemical binding]; other site 1254439002443 Walker B motif; other site 1254439002444 TrwC relaxase; Region: TrwC; pfam08751 1254439002445 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1254439002446 AAA domain; Region: AAA_30; pfam13604 1254439002447 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1254439002448 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1254439002449 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1254439002450 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1254439002451 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1254439002452 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1254439002453 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1254439002454 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1254439002455 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1254439002456 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1254439002457 Haemolysin-III related; Region: HlyIII; pfam03006 1254439002458 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1254439002459 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1254439002460 PAS fold; Region: PAS_4; pfam08448 1254439002461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1254439002462 Histidine kinase; Region: HisKA_2; pfam07568 1254439002463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1254439002464 ATP binding site [chemical binding]; other site 1254439002465 Mg2+ binding site [ion binding]; other site 1254439002466 G-X-G motif; other site 1254439002467 Transcription factor WhiB; Region: Whib; pfam02467 1254439002468 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1254439002469 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1254439002470 G1 box; other site 1254439002471 GTP/Mg2+ binding site [chemical binding]; other site 1254439002472 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1254439002473 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1254439002474 Transcription factor WhiB; Region: Whib; pfam02467 1254439002475 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1254439002476 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1254439002477 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1254439002478 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1254439002479 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1254439002480 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1254439002481 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1254439002482 active site 1254439002483 DNA binding site [nucleotide binding] 1254439002484 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1254439002485 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1254439002486 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1254439002487 Catalytic site [active] 1254439002488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1254439002489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1254439002490 dimerization interface [polypeptide binding]; other site 1254439002491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1254439002492 dimer interface [polypeptide binding]; other site 1254439002493 phosphorylation site [posttranslational modification] 1254439002494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1254439002495 ATP binding site [chemical binding]; other site 1254439002496 Mg2+ binding site [ion binding]; other site 1254439002497 G-X-G motif; other site 1254439002498 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1254439002499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1254439002500 active site 1254439002501 phosphorylation site [posttranslational modification] 1254439002502 intermolecular recognition site; other site 1254439002503 dimerization interface [polypeptide binding]; other site 1254439002504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1254439002505 DNA binding site [nucleotide binding] 1254439002506 glycogen branching enzyme; Provisional; Region: PRK05402 1254439002507 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1254439002508 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1254439002509 active site 1254439002510 catalytic site [active] 1254439002511 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1254439002512 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1254439002513 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1254439002514 homotrimer interaction site [polypeptide binding]; other site 1254439002515 zinc binding site [ion binding]; other site 1254439002516 CDP-binding sites; other site 1254439002517 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1254439002518 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1254439002519 dimer interface [polypeptide binding]; other site 1254439002520 putative PBP binding regions; other site 1254439002521 ABC-ATPase subunit interface; other site 1254439002522 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1254439002523 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1254439002524 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1254439002525 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1254439002526 intersubunit interface [polypeptide binding]; other site 1254439002527 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1254439002528 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1254439002529 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1254439002530 homodimer interface [polypeptide binding]; other site 1254439002531 NADP binding site [chemical binding]; other site 1254439002532 substrate binding site [chemical binding]; other site 1254439002533 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1254439002534 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1254439002535 RNA binding site [nucleotide binding]; other site 1254439002536 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1254439002537 RNA binding site [nucleotide binding]; other site 1254439002538 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1254439002539 RNA binding site [nucleotide binding]; other site 1254439002540 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1254439002541 RNA binding site [nucleotide binding]; other site 1254439002542 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1254439002543 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1254439002544 CoA-binding site [chemical binding]; other site 1254439002545 ATP-binding [chemical binding]; other site 1254439002546 excinuclease ABC subunit B; Provisional; Region: PRK05298 1254439002547 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1254439002548 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1254439002549 nucleotide binding region [chemical binding]; other site 1254439002550 ATP-binding site [chemical binding]; other site 1254439002551 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1254439002552 UvrB/uvrC motif; Region: UVR; pfam02151 1254439002553 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1254439002554 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1254439002555 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1254439002556 domain interfaces; other site 1254439002557 active site 1254439002558 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1254439002559 dimer interface [polypeptide binding]; other site 1254439002560 ADP-ribose binding site [chemical binding]; other site 1254439002561 active site 1254439002562 nudix motif; other site 1254439002563 metal binding site [ion binding]; metal-binding site 1254439002564 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1254439002565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439002566 Walker A/P-loop; other site 1254439002567 ATP binding site [chemical binding]; other site 1254439002568 Q-loop/lid; other site 1254439002569 ABC transporter signature motif; other site 1254439002570 Walker B; other site 1254439002571 D-loop; other site 1254439002572 H-loop/switch region; other site 1254439002573 TOBE domain; Region: TOBE_2; pfam08402 1254439002574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439002575 dimer interface [polypeptide binding]; other site 1254439002576 conserved gate region; other site 1254439002577 putative PBP binding loops; other site 1254439002578 ABC-ATPase subunit interface; other site 1254439002579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1254439002580 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1254439002581 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1254439002582 MULE transposase domain; Region: MULE; pfam10551 1254439002583 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1254439002584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1254439002585 active site 1254439002586 phosphorylation site [posttranslational modification] 1254439002587 intermolecular recognition site; other site 1254439002588 dimerization interface [polypeptide binding]; other site 1254439002589 ANTAR domain; Region: ANTAR; pfam03861 1254439002590 5'-3' exonuclease; Region: 53EXOc; smart00475 1254439002591 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1254439002592 active site 1254439002593 metal binding site 1 [ion binding]; metal-binding site 1254439002594 putative 5' ssDNA interaction site; other site 1254439002595 metal binding site 3; metal-binding site 1254439002596 metal binding site 2 [ion binding]; metal-binding site 1254439002597 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1254439002598 putative DNA binding site [nucleotide binding]; other site 1254439002599 putative metal binding site [ion binding]; other site 1254439002600 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 1254439002601 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1254439002602 active site 1254439002603 substrate binding site [chemical binding]; other site 1254439002604 catalytic site [active] 1254439002605 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1254439002606 active site 1254439002607 DNA binding site [nucleotide binding] 1254439002608 catalytic site [active] 1254439002609 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1254439002610 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1254439002611 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1254439002612 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1254439002613 dimer interface [polypeptide binding]; other site 1254439002614 ADP-ribose binding site [chemical binding]; other site 1254439002615 active site 1254439002616 nudix motif; other site 1254439002617 metal binding site [ion binding]; metal-binding site 1254439002618 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1254439002619 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1254439002620 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1254439002621 active site 1254439002622 catalytic site [active] 1254439002623 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1254439002624 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1254439002625 hinge; other site 1254439002626 active site 1254439002627 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1254439002628 propionate/acetate kinase; Provisional; Region: PRK12379 1254439002629 AAA domain; Region: AAA_26; pfam13500 1254439002630 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1254439002631 putative phosphoketolase; Provisional; Region: PRK05261 1254439002632 XFP N-terminal domain; Region: XFP_N; pfam09364 1254439002633 XFP C-terminal domain; Region: XFP_C; pfam09363 1254439002634 GMP synthase; Reviewed; Region: guaA; PRK00074 1254439002635 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1254439002636 AMP/PPi binding site [chemical binding]; other site 1254439002637 candidate oxyanion hole; other site 1254439002638 catalytic triad [active] 1254439002639 potential glutamine specificity residues [chemical binding]; other site 1254439002640 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1254439002641 ATP Binding subdomain [chemical binding]; other site 1254439002642 Ligand Binding sites [chemical binding]; other site 1254439002643 Dimerization subdomain; other site 1254439002644 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1254439002645 Divergent AAA domain; Region: AAA_4; pfam04326 1254439002646 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1254439002647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439002648 Walker A/P-loop; other site 1254439002649 ATP binding site [chemical binding]; other site 1254439002650 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1254439002651 putative active site [active] 1254439002652 putative metal-binding site [ion binding]; other site 1254439002653 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1254439002654 Part of AAA domain; Region: AAA_19; pfam13245 1254439002655 Family description; Region: UvrD_C_2; pfam13538 1254439002656 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1254439002657 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1254439002658 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1254439002659 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1254439002660 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1254439002661 catalytic residue [active] 1254439002662 allantoate amidohydrolase; Reviewed; Region: PRK09290 1254439002663 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1254439002664 active site 1254439002665 metal binding site [ion binding]; metal-binding site 1254439002666 dimer interface [polypeptide binding]; other site 1254439002667 allantoinase; Region: allantoinase; TIGR03178 1254439002668 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1254439002669 active site 1254439002670 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1254439002671 indole-3-acetamide amidohydrolase; Region: PLN02722 1254439002672 Amidase; Region: Amidase; cl11426 1254439002673 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1254439002674 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1254439002675 Na binding site [ion binding]; other site 1254439002676 putative substrate binding site [chemical binding]; other site 1254439002677 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1254439002678 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1254439002679 Sel1 repeat; Region: Sel1; cl02723 1254439002680 Sel1-like repeats; Region: SEL1; smart00671 1254439002681 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1254439002682 putative transposase OrfB; Reviewed; Region: PHA02517 1254439002683 HTH-like domain; Region: HTH_21; pfam13276 1254439002684 Integrase core domain; Region: rve; pfam00665 1254439002685 Integrase core domain; Region: rve_2; pfam13333 1254439002686 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1254439002687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439002688 Walker A motif; other site 1254439002689 ATP binding site [chemical binding]; other site 1254439002690 Walker B motif; other site 1254439002691 arginine finger; other site 1254439002692 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1254439002693 Helix-turn-helix domain; Region: HTH_17; pfam12728 1254439002694 Amidase; Region: Amidase; cl11426 1254439002695 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1254439002696 Amidase; Region: Amidase; cl11426 1254439002697 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1254439002698 Sel1-like repeats; Region: SEL1; smart00671 1254439002699 Sel1 repeat; Region: Sel1; cl02723 1254439002700 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1254439002701 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1254439002702 active site 1254439002703 GIY-YIG motif/motif A; other site 1254439002704 catalytic site [active] 1254439002705 metal binding site [ion binding]; metal-binding site 1254439002706 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1254439002707 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1254439002708 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1254439002709 Protein of unknown function DUF262; Region: DUF262; pfam03235 1254439002710 Protein of unknown function DUF262; Region: DUF262; pfam03235 1254439002711 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1254439002712 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1254439002713 potential frameshift: common BLAST hit: gi|310287891|ref|YP_003939149.1| ABC transporter 1254439002714 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1254439002715 ABC transporter; Region: ABC_tran; pfam00005 1254439002716 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1254439002717 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1254439002718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439002719 putative substrate translocation pore; other site 1254439002720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1254439002721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439002722 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1254439002723 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1254439002724 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1254439002725 G1 box; other site 1254439002726 GTP/Mg2+ binding site [chemical binding]; other site 1254439002727 Switch I region; other site 1254439002728 G2 box; other site 1254439002729 G3 box; other site 1254439002730 Switch II region; other site 1254439002731 G4 box; other site 1254439002732 G5 box; other site 1254439002733 Nucleoside recognition; Region: Gate; pfam07670 1254439002734 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1254439002735 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1254439002736 active site 1254439002737 DNA binding site [nucleotide binding] 1254439002738 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1254439002739 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1254439002740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439002741 Walker A/P-loop; other site 1254439002742 ATP binding site [chemical binding]; other site 1254439002743 Q-loop/lid; other site 1254439002744 ABC transporter signature motif; other site 1254439002745 Walker B; other site 1254439002746 D-loop; other site 1254439002747 H-loop/switch region; other site 1254439002748 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1254439002749 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1254439002750 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1254439002751 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1254439002752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1254439002753 Coenzyme A binding pocket [chemical binding]; other site 1254439002754 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1254439002755 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1254439002756 active site 1254439002757 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1254439002758 AAA ATPase domain; Region: AAA_16; pfam13191 1254439002759 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1254439002760 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1254439002761 ATP binding site [chemical binding]; other site 1254439002762 putative Mg++ binding site [ion binding]; other site 1254439002763 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1254439002764 nucleotide binding region [chemical binding]; other site 1254439002765 ATP-binding site [chemical binding]; other site 1254439002766 Divergent AAA domain; Region: AAA_4; pfam04326 1254439002767 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1254439002768 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1254439002769 putative DNA binding site [nucleotide binding]; other site 1254439002770 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1254439002771 putative Zn2+ binding site [ion binding]; other site 1254439002772 xanthine permease; Region: pbuX; TIGR03173 1254439002773 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1254439002774 active site 1254439002775 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1254439002776 Part of AAA domain; Region: AAA_19; pfam13245 1254439002777 Family description; Region: UvrD_C_2; pfam13538 1254439002778 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1254439002779 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1254439002780 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1254439002781 RNA binding surface [nucleotide binding]; other site 1254439002782 Membrane protein of unknown function; Region: DUF360; pfam04020 1254439002783 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1254439002784 active site 1254439002785 catalytic triad [active] 1254439002786 oxyanion hole [active] 1254439002787 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1254439002788 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1254439002789 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1254439002790 catalytic core [active] 1254439002791 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1254439002792 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1254439002793 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1254439002794 motif 1; other site 1254439002795 active site 1254439002796 motif 2; other site 1254439002797 motif 3; other site 1254439002798 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1254439002799 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1254439002800 YceG-like family; Region: YceG; pfam02618 1254439002801 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1254439002802 dimerization interface [polypeptide binding]; other site 1254439002803 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1254439002804 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1254439002805 Tetramer interface [polypeptide binding]; other site 1254439002806 active site 1254439002807 FMN-binding site [chemical binding]; other site 1254439002808 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 1254439002809 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1254439002810 ADP binding site [chemical binding]; other site 1254439002811 magnesium binding site [ion binding]; other site 1254439002812 putative shikimate binding site; other site 1254439002813 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1254439002814 active site 1254439002815 dimer interface [polypeptide binding]; other site 1254439002816 metal binding site [ion binding]; metal-binding site 1254439002817 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1254439002818 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1254439002819 trimer interface [polypeptide binding]; other site 1254439002820 active site 1254439002821 dimer interface [polypeptide binding]; other site 1254439002822 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 1254439002823 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1254439002824 active site 1254439002825 Ca binding site [ion binding]; other site 1254439002826 catalytic site [active] 1254439002827 Aamy_C domain; Region: Aamy_C; smart00632 1254439002828 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 1254439002829 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1254439002830 carbohydrate binding site [chemical binding]; other site 1254439002831 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1254439002832 carbohydrate binding site [chemical binding]; other site 1254439002833 pullulanase, type I; Region: pulA_typeI; TIGR02104 1254439002834 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1254439002835 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1254439002836 Ca binding site [ion binding]; other site 1254439002837 active site 1254439002838 catalytic site [active] 1254439002839 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 1254439002840 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1254439002841 active site 1254439002842 Ca binding site [ion binding]; other site 1254439002843 catalytic site [active] 1254439002844 Aamy_C domain; Region: Aamy_C; smart00632 1254439002845 CTP synthetase; Validated; Region: pyrG; PRK05380 1254439002846 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1254439002847 Catalytic site [active] 1254439002848 active site 1254439002849 UTP binding site [chemical binding]; other site 1254439002850 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1254439002851 active site 1254439002852 putative oxyanion hole; other site 1254439002853 catalytic triad [active] 1254439002854 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1254439002855 FeS assembly protein SufB; Region: sufB; TIGR01980 1254439002856 FeS assembly protein SufD; Region: sufD; TIGR01981 1254439002857 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1254439002858 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1254439002859 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1254439002860 Walker A/P-loop; other site 1254439002861 ATP binding site [chemical binding]; other site 1254439002862 Q-loop/lid; other site 1254439002863 ABC transporter signature motif; other site 1254439002864 Walker B; other site 1254439002865 D-loop; other site 1254439002866 H-loop/switch region; other site 1254439002867 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1254439002868 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1254439002869 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1254439002870 catalytic residue [active] 1254439002871 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1254439002872 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1254439002873 trimerization site [polypeptide binding]; other site 1254439002874 active site 1254439002875 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1254439002876 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1254439002877 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1254439002878 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1254439002879 RNA methyltransferase, RsmE family; Region: TIGR00046 1254439002880 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1254439002881 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1254439002882 nucleotide binding site/active site [active] 1254439002883 HIT family signature motif; other site 1254439002884 catalytic residue [active] 1254439002885 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1254439002886 PhoH-like protein; Region: PhoH; pfam02562 1254439002887 metal-binding heat shock protein; Provisional; Region: PRK00016 1254439002888 FOG: CBS domain [General function prediction only]; Region: COG0517 1254439002889 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1254439002890 Transporter associated domain; Region: CorC_HlyC; smart01091 1254439002891 GTPase Era; Reviewed; Region: era; PRK00089 1254439002892 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1254439002893 G1 box; other site 1254439002894 GTP/Mg2+ binding site [chemical binding]; other site 1254439002895 Switch I region; other site 1254439002896 G2 box; other site 1254439002897 Switch II region; other site 1254439002898 G3 box; other site 1254439002899 G4 box; other site 1254439002900 G5 box; other site 1254439002901 KH domain; Region: KH_2; pfam07650 1254439002902 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1254439002903 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1254439002904 acyl-activating enzyme (AAE) consensus motif; other site 1254439002905 putative AMP binding site [chemical binding]; other site 1254439002906 putative active site [active] 1254439002907 putative CoA binding site [chemical binding]; other site 1254439002908 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1254439002909 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1254439002910 NAD binding site [chemical binding]; other site 1254439002911 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1254439002912 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1254439002913 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1254439002914 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1254439002915 Cutinase; Region: Cutinase; pfam01083 1254439002916 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1254439002917 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1254439002918 5S rRNA interface [nucleotide binding]; other site 1254439002919 CTC domain interface [polypeptide binding]; other site 1254439002920 L16 interface [polypeptide binding]; other site 1254439002921 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1254439002922 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1254439002923 homodimer interface [polypeptide binding]; other site 1254439002924 substrate-cofactor binding pocket; other site 1254439002925 catalytic residue [active] 1254439002926 Predicted membrane protein [Function unknown]; Region: COG2860 1254439002927 UPF0126 domain; Region: UPF0126; pfam03458 1254439002928 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1254439002929 GTP-binding protein LepA; Provisional; Region: PRK05433 1254439002930 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1254439002931 G1 box; other site 1254439002932 putative GEF interaction site [polypeptide binding]; other site 1254439002933 GTP/Mg2+ binding site [chemical binding]; other site 1254439002934 Switch I region; other site 1254439002935 G2 box; other site 1254439002936 G3 box; other site 1254439002937 Switch II region; other site 1254439002938 G4 box; other site 1254439002939 G5 box; other site 1254439002940 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1254439002941 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1254439002942 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1254439002943 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1254439002944 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1254439002945 FeS/SAM binding site; other site 1254439002946 HemN C-terminal domain; Region: HemN_C; pfam06969 1254439002947 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1254439002948 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1254439002949 minor groove reading motif; other site 1254439002950 helix-hairpin-helix signature motif; other site 1254439002951 substrate binding pocket [chemical binding]; other site 1254439002952 active site 1254439002953 potential frameshift: common BLAST hit: gi|384201899|ref|YP_005587646.1| excinuclease ATPase subunit 1254439002954 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1254439002955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439002956 ABC transporter signature motif; other site 1254439002957 Walker B; other site 1254439002958 D-loop; other site 1254439002959 H-loop/switch region; other site 1254439002960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439002961 Walker A/P-loop; other site 1254439002962 ATP binding site [chemical binding]; other site 1254439002963 Q-loop/lid; other site 1254439002964 ABC transporter signature motif; other site 1254439002965 Walker B; other site 1254439002966 D-loop; other site 1254439002967 H-loop/switch region; other site 1254439002968 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1254439002969 putative active site [active] 1254439002970 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1254439002971 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1254439002972 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1254439002973 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1254439002974 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1254439002975 active site 1254439002976 substrate binding site [chemical binding]; other site 1254439002977 trimer interface [polypeptide binding]; other site 1254439002978 CoA binding site [chemical binding]; other site 1254439002979 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1254439002980 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1254439002981 active site 1254439002982 dimer interface [polypeptide binding]; other site 1254439002983 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1254439002984 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1254439002985 active site 1254439002986 FMN binding site [chemical binding]; other site 1254439002987 substrate binding site [chemical binding]; other site 1254439002988 3Fe-4S cluster binding site [ion binding]; other site 1254439002989 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1254439002990 domain interface; other site 1254439002991 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1254439002992 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1254439002993 Bacterial PH domain; Region: DUF304; cl01348 1254439002994 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1254439002995 Peptidase family M23; Region: Peptidase_M23; pfam01551 1254439002996 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1254439002997 isocitrate dehydrogenase; Validated; Region: PRK08299 1254439002998 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1254439002999 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1254439003000 active site 1254439003001 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1254439003002 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1254439003003 acyl-activating enzyme (AAE) consensus motif; other site 1254439003004 putative AMP binding site [chemical binding]; other site 1254439003005 putative active site [active] 1254439003006 putative CoA binding site [chemical binding]; other site 1254439003007 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1254439003008 active site 1254439003009 catalytic residues [active] 1254439003010 metal binding site [ion binding]; metal-binding site 1254439003011 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1254439003012 rRNA interaction site [nucleotide binding]; other site 1254439003013 S8 interaction site; other site 1254439003014 putative laminin-1 binding site; other site 1254439003015 elongation factor Ts; Provisional; Region: tsf; PRK09377 1254439003016 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1254439003017 Elongation factor TS; Region: EF_TS; pfam00889 1254439003018 Elongation factor TS; Region: EF_TS; pfam00889 1254439003019 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1254439003020 putative nucleotide binding site [chemical binding]; other site 1254439003021 uridine monophosphate binding site [chemical binding]; other site 1254439003022 homohexameric interface [polypeptide binding]; other site 1254439003023 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1254439003024 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1254439003025 hinge region; other site 1254439003026 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1254439003027 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1254439003028 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1254439003029 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1254439003030 FeS/SAM binding site; other site 1254439003031 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1254439003032 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1254439003033 substrate binding site [chemical binding]; other site 1254439003034 glutamase interaction surface [polypeptide binding]; other site 1254439003035 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1254439003036 anthranilate synthase component I; Provisional; Region: PRK13571 1254439003037 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1254439003038 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1254439003039 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 1254439003040 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1254439003041 active site 1254439003042 ribulose/triose binding site [chemical binding]; other site 1254439003043 phosphate binding site [ion binding]; other site 1254439003044 substrate (anthranilate) binding pocket [chemical binding]; other site 1254439003045 product (indole) binding pocket [chemical binding]; other site 1254439003046 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1254439003047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439003048 catalytic residue [active] 1254439003049 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1254439003050 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1254439003051 substrate binding site [chemical binding]; other site 1254439003052 active site 1254439003053 catalytic residues [active] 1254439003054 heterodimer interface [polypeptide binding]; other site 1254439003055 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1254439003056 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1254439003057 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1254439003058 substrate binding site [chemical binding]; other site 1254439003059 hexamer interface [polypeptide binding]; other site 1254439003060 metal binding site [ion binding]; metal-binding site 1254439003061 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1254439003062 homodimer interface [polypeptide binding]; other site 1254439003063 putative metal binding site [ion binding]; other site 1254439003064 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1254439003065 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1254439003066 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1254439003067 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1254439003068 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1254439003069 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 1254439003070 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1254439003071 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1254439003072 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1254439003073 phosphopeptide binding site; other site 1254439003074 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1254439003075 DNA binding residues [nucleotide binding] 1254439003076 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1254439003077 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1254439003078 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439003079 motif II; other site 1254439003080 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1254439003081 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1254439003082 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1254439003083 ATP binding site [chemical binding]; other site 1254439003084 putative Mg++ binding site [ion binding]; other site 1254439003085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1254439003086 nucleotide binding region [chemical binding]; other site 1254439003087 ATP-binding site [chemical binding]; other site 1254439003088 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1254439003089 Predicted transcriptional regulator [Transcription]; Region: COG2378 1254439003090 WYL domain; Region: WYL; pfam13280 1254439003091 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1254439003092 active site 1254439003093 MULE transposase domain; Region: MULE; pfam10551 1254439003094 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 1254439003095 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1254439003096 CMP-binding site; other site 1254439003097 The sites determining sugar specificity; other site 1254439003098 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1254439003099 G1 box; other site 1254439003100 GTP/Mg2+ binding site [chemical binding]; other site 1254439003101 Switch I region; other site 1254439003102 G2 box; other site 1254439003103 Switch II region; other site 1254439003104 G3 box; other site 1254439003105 G4 box; other site 1254439003106 G5 box; other site 1254439003107 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1254439003108 G1 box; other site 1254439003109 GTP/Mg2+ binding site [chemical binding]; other site 1254439003110 Switch I region; other site 1254439003111 G2 box; other site 1254439003112 G3 box; other site 1254439003113 Switch II region; other site 1254439003114 G4 box; other site 1254439003115 G5 box; other site 1254439003116 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1254439003117 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1254439003118 RNA binding surface [nucleotide binding]; other site 1254439003119 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1254439003120 active site 1254439003121 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1254439003122 amphipathic channel; other site 1254439003123 Asn-Pro-Ala signature motifs; other site 1254439003124 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1254439003125 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1254439003126 purine monophosphate binding site [chemical binding]; other site 1254439003127 dimer interface [polypeptide binding]; other site 1254439003128 putative catalytic residues [active] 1254439003129 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1254439003130 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1254439003131 TM-ABC transporter signature motif; other site 1254439003132 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1254439003133 CoA binding domain; Region: CoA_binding; pfam02629 1254439003134 CoA-ligase; Region: Ligase_CoA; pfam00549 1254439003135 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1254439003136 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1254439003137 CoA-ligase; Region: Ligase_CoA; pfam00549 1254439003138 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1254439003139 active site 1254439003140 Preprotein translocase subunit; Region: YajC; pfam02699 1254439003141 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1254439003142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439003143 Walker A motif; other site 1254439003144 ATP binding site [chemical binding]; other site 1254439003145 Walker B motif; other site 1254439003146 arginine finger; other site 1254439003147 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1254439003148 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1254439003149 RuvA N terminal domain; Region: RuvA_N; pfam01330 1254439003150 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 1254439003151 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1254439003152 active site 1254439003153 putative DNA-binding cleft [nucleotide binding]; other site 1254439003154 dimer interface [polypeptide binding]; other site 1254439003155 hypothetical protein; Validated; Region: PRK00110 1254439003156 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1254439003157 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1254439003158 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1254439003159 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1254439003160 putative acyl-acceptor binding pocket; other site 1254439003161 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1254439003162 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1254439003163 thiS-thiF/thiG interaction site; other site 1254439003164 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1254439003165 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1254439003166 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1254439003167 active site 1254439003168 dimer interface [polypeptide binding]; other site 1254439003169 motif 1; other site 1254439003170 motif 2; other site 1254439003171 motif 3; other site 1254439003172 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1254439003173 anticodon binding site; other site 1254439003174 PAC2 family; Region: PAC2; pfam09754 1254439003175 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1254439003176 putative active site [active] 1254439003177 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1254439003178 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1254439003179 Phosphotransferase enzyme family; Region: APH; pfam01636 1254439003180 chaperone protein DnaJ; Provisional; Region: PRK14278 1254439003181 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1254439003182 HSP70 interaction site [polypeptide binding]; other site 1254439003183 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1254439003184 Zn binding sites [ion binding]; other site 1254439003185 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1254439003186 dimer interface [polypeptide binding]; other site 1254439003187 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1254439003188 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 1254439003189 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1254439003190 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1254439003191 TPP-binding site [chemical binding]; other site 1254439003192 dimer interface [polypeptide binding]; other site 1254439003193 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1254439003194 PYR/PP interface [polypeptide binding]; other site 1254439003195 dimer interface [polypeptide binding]; other site 1254439003196 TPP binding site [chemical binding]; other site 1254439003197 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1254439003198 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1254439003199 putative active site [active] 1254439003200 transaldolase; Provisional; Region: PRK03903 1254439003201 catalytic residue [active] 1254439003202 aminotransferase AlaT; Validated; Region: PRK09265 1254439003203 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1254439003204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439003205 homodimer interface [polypeptide binding]; other site 1254439003206 catalytic residue [active] 1254439003207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439003208 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1254439003209 active site 1254439003210 motif I; other site 1254439003211 motif II; other site 1254439003212 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1254439003213 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1254439003214 triosephosphate isomerase; Provisional; Region: PRK14567 1254439003215 substrate binding site [chemical binding]; other site 1254439003216 dimer interface [polypeptide binding]; other site 1254439003217 catalytic triad [active] 1254439003218 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1254439003219 Phosphoglycerate kinase; Region: PGK; pfam00162 1254439003220 substrate binding site [chemical binding]; other site 1254439003221 hinge regions; other site 1254439003222 ADP binding site [chemical binding]; other site 1254439003223 catalytic site [active] 1254439003224 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 1254439003225 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1254439003226 AAA domain; Region: AAA_33; pfam13671 1254439003227 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1254439003228 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1254439003229 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1254439003230 shikimate binding site; other site 1254439003231 NAD(P) binding site [chemical binding]; other site 1254439003232 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1254439003233 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1254439003234 GIY-YIG motif/motif A; other site 1254439003235 active site 1254439003236 catalytic site [active] 1254439003237 putative DNA binding site [nucleotide binding]; other site 1254439003238 metal binding site [ion binding]; metal-binding site 1254439003239 UvrB/uvrC motif; Region: UVR; pfam02151 1254439003240 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1254439003241 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1254439003242 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1254439003243 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1254439003244 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1254439003245 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1254439003246 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1254439003247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439003248 Walker A/P-loop; other site 1254439003249 ATP binding site [chemical binding]; other site 1254439003250 Q-loop/lid; other site 1254439003251 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1254439003252 ABC transporter signature motif; other site 1254439003253 Walker B; other site 1254439003254 D-loop; other site 1254439003255 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1254439003256 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1254439003257 active site 1254439003258 catalytic triad [active] 1254439003259 oxyanion hole [active] 1254439003260 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1254439003261 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1254439003262 putative substrate binding site [chemical binding]; other site 1254439003263 putative ATP binding site [chemical binding]; other site 1254439003264 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1254439003265 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1254439003266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439003267 motif II; other site 1254439003268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1254439003269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1254439003270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1254439003271 dimerization interface [polypeptide binding]; other site 1254439003272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1254439003273 active site 1254439003274 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1254439003275 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1254439003276 heterodimer interface [polypeptide binding]; other site 1254439003277 active site 1254439003278 FMN binding site [chemical binding]; other site 1254439003279 homodimer interface [polypeptide binding]; other site 1254439003280 substrate binding site [chemical binding]; other site 1254439003281 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1254439003282 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1254439003283 FAD binding pocket [chemical binding]; other site 1254439003284 FAD binding motif [chemical binding]; other site 1254439003285 phosphate binding motif [ion binding]; other site 1254439003286 beta-alpha-beta structure motif; other site 1254439003287 NAD binding pocket [chemical binding]; other site 1254439003288 Iron coordination center [ion binding]; other site 1254439003289 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1254439003290 active site 1254439003291 dimer interface [polypeptide binding]; other site 1254439003292 dihydroorotase; Validated; Region: pyrC; PRK09357 1254439003293 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1254439003294 active site 1254439003295 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1254439003296 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1254439003297 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1254439003298 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1254439003299 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1254439003300 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1254439003301 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1254439003302 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1254439003303 metal binding triad; other site 1254439003304 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1254439003305 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1254439003306 metal binding triad; other site 1254439003307 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1254439003308 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1254439003309 FAD binding site [chemical binding]; other site 1254439003310 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1254439003311 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1254439003312 THF binding site; other site 1254439003313 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1254439003314 substrate binding site [chemical binding]; other site 1254439003315 THF binding site; other site 1254439003316 zinc-binding site [ion binding]; other site 1254439003317 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1254439003318 catalytic core [active] 1254439003319 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1254439003320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1254439003321 S-adenosylmethionine binding site [chemical binding]; other site 1254439003322 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1254439003323 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1254439003324 Walker A/P-loop; other site 1254439003325 ATP binding site [chemical binding]; other site 1254439003326 Q-loop/lid; other site 1254439003327 ABC transporter signature motif; other site 1254439003328 Walker B; other site 1254439003329 D-loop; other site 1254439003330 H-loop/switch region; other site 1254439003331 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1254439003332 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1254439003333 AzlC protein; Region: AzlC; cl00570 1254439003334 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1254439003335 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1254439003336 acyl-activating enzyme (AAE) consensus motif; other site 1254439003337 putative AMP binding site [chemical binding]; other site 1254439003338 putative active site [active] 1254439003339 putative CoA binding site [chemical binding]; other site 1254439003340 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1254439003341 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1254439003342 active site 1254439003343 NAD binding site [chemical binding]; other site 1254439003344 metal binding site [ion binding]; metal-binding site 1254439003345 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1254439003346 recombination factor protein RarA; Reviewed; Region: PRK13342 1254439003347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439003348 Walker A motif; other site 1254439003349 ATP binding site [chemical binding]; other site 1254439003350 Walker B motif; other site 1254439003351 arginine finger; other site 1254439003352 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1254439003353 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1254439003354 ATP binding site [chemical binding]; other site 1254439003355 putative Mg++ binding site [ion binding]; other site 1254439003356 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1254439003357 nucleotide binding region [chemical binding]; other site 1254439003358 ATP-binding site [chemical binding]; other site 1254439003359 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1254439003360 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1254439003361 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1254439003362 putative deacylase active site [active] 1254439003363 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1254439003364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439003365 dimer interface [polypeptide binding]; other site 1254439003366 conserved gate region; other site 1254439003367 putative PBP binding loops; other site 1254439003368 ABC-ATPase subunit interface; other site 1254439003369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439003370 dimer interface [polypeptide binding]; other site 1254439003371 conserved gate region; other site 1254439003372 ABC-ATPase subunit interface; other site 1254439003373 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1254439003374 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1254439003375 substrate binding pocket [chemical binding]; other site 1254439003376 membrane-bound complex binding site; other site 1254439003377 hinge residues; other site 1254439003378 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1254439003379 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1254439003380 Walker A/P-loop; other site 1254439003381 ATP binding site [chemical binding]; other site 1254439003382 Q-loop/lid; other site 1254439003383 ABC transporter signature motif; other site 1254439003384 Walker B; other site 1254439003385 D-loop; other site 1254439003386 H-loop/switch region; other site 1254439003387 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1254439003388 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1254439003389 dimer interface [polypeptide binding]; other site 1254439003390 anticodon binding site; other site 1254439003391 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1254439003392 motif 1; other site 1254439003393 dimer interface [polypeptide binding]; other site 1254439003394 active site 1254439003395 motif 2; other site 1254439003396 GAD domain; Region: GAD; pfam02938 1254439003397 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1254439003398 active site 1254439003399 motif 3; other site 1254439003400 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1254439003401 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1254439003402 dimer interface [polypeptide binding]; other site 1254439003403 motif 1; other site 1254439003404 active site 1254439003405 motif 2; other site 1254439003406 motif 3; other site 1254439003407 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1254439003408 anticodon binding site; other site 1254439003409 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1254439003410 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1254439003411 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1254439003412 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1254439003413 Clp amino terminal domain; Region: Clp_N; pfam02861 1254439003414 Clp amino terminal domain; Region: Clp_N; pfam02861 1254439003415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439003416 Walker A motif; other site 1254439003417 ATP binding site [chemical binding]; other site 1254439003418 Walker B motif; other site 1254439003419 arginine finger; other site 1254439003420 UvrB/uvrC motif; Region: UVR; pfam02151 1254439003421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439003422 Walker A motif; other site 1254439003423 ATP binding site [chemical binding]; other site 1254439003424 Walker B motif; other site 1254439003425 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1254439003426 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1254439003427 Ligand Binding Site [chemical binding]; other site 1254439003428 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1254439003429 Ligand Binding Site [chemical binding]; other site 1254439003430 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1254439003431 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1254439003432 DNA-binding site [nucleotide binding]; DNA binding site 1254439003433 RNA-binding motif; other site 1254439003434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1254439003435 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1254439003436 dimerization interface [polypeptide binding]; other site 1254439003437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1254439003438 dimer interface [polypeptide binding]; other site 1254439003439 phosphorylation site [posttranslational modification] 1254439003440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1254439003441 ATP binding site [chemical binding]; other site 1254439003442 Mg2+ binding site [ion binding]; other site 1254439003443 G-X-G motif; other site 1254439003444 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1254439003445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1254439003446 active site 1254439003447 phosphorylation site [posttranslational modification] 1254439003448 intermolecular recognition site; other site 1254439003449 dimerization interface [polypeptide binding]; other site 1254439003450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1254439003451 DNA binding site [nucleotide binding] 1254439003452 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1254439003453 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1254439003454 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1254439003455 ring oligomerisation interface [polypeptide binding]; other site 1254439003456 ATP/Mg binding site [chemical binding]; other site 1254439003457 stacking interactions; other site 1254439003458 hinge regions; other site 1254439003459 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1254439003460 DNA-binding site [nucleotide binding]; DNA binding site 1254439003461 RNA-binding motif; other site 1254439003462 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1254439003463 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1254439003464 ligand binding site [chemical binding]; other site 1254439003465 active site 1254439003466 UGI interface [polypeptide binding]; other site 1254439003467 catalytic site [active] 1254439003468 MoxR-like ATPases [General function prediction only]; Region: COG0714 1254439003469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1254439003470 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1254439003471 Protein of unknown function DUF58; Region: DUF58; pfam01882 1254439003472 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1254439003473 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1254439003474 PGAP1-like protein; Region: PGAP1; pfam07819 1254439003475 adenylosuccinate lyase; Provisional; Region: PRK09285 1254439003476 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1254439003477 tetramer interface [polypeptide binding]; other site 1254439003478 active site 1254439003479 Predicted integral membrane protein [Function unknown]; Region: COG0392 1254439003480 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1254439003481 IHF dimer interface [polypeptide binding]; other site 1254439003482 IHF - DNA interface [nucleotide binding]; other site 1254439003483 Pup-ligase protein; Region: Pup_ligase; cl15463 1254439003484 ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687 1254439003485 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1254439003486 active site 1254439003487 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1254439003488 Pup-ligase protein; Region: Pup_ligase; cl15463 1254439003489 proteasome ATPase; Region: pup_AAA; TIGR03689 1254439003490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439003491 Walker A motif; other site 1254439003492 ATP binding site [chemical binding]; other site 1254439003493 Walker B motif; other site 1254439003494 arginine finger; other site 1254439003495 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1254439003496 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1254439003497 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1254439003498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439003499 motif II; other site 1254439003500 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1254439003501 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1254439003502 putative active site [active] 1254439003503 substrate binding site [chemical binding]; other site 1254439003504 putative cosubstrate binding site; other site 1254439003505 catalytic site [active] 1254439003506 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1254439003507 substrate binding site [chemical binding]; other site 1254439003508 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1254439003509 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1254439003510 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 1254439003511 primosome assembly protein PriA; Provisional; Region: PRK14873 1254439003512 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1254439003513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1254439003514 S-adenosylmethionine binding site [chemical binding]; other site 1254439003515 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1254439003516 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1254439003517 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1254439003518 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1254439003519 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1254439003520 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1254439003521 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1254439003522 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1254439003523 catalytic site [active] 1254439003524 G-X2-G-X-G-K; other site 1254439003525 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1254439003526 active site 1254439003527 dimer interface [polypeptide binding]; other site 1254439003528 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1254439003529 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1254439003530 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1254439003531 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1254439003532 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1254439003533 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1254439003534 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1254439003535 IMP binding site; other site 1254439003536 dimer interface [polypeptide binding]; other site 1254439003537 interdomain contacts; other site 1254439003538 partial ornithine binding site; other site 1254439003539 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1254439003540 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1254439003541 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1254439003542 catalytic site [active] 1254439003543 subunit interface [polypeptide binding]; other site 1254439003544 transcription antitermination factor NusB; Region: nusB; TIGR01951 1254439003545 putative RNA binding site [nucleotide binding]; other site 1254439003546 elongation factor P; Validated; Region: PRK00529 1254439003547 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1254439003548 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1254439003549 RNA binding site [nucleotide binding]; other site 1254439003550 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1254439003551 RNA binding site [nucleotide binding]; other site 1254439003552 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1254439003553 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1254439003554 active site 1254439003555 FMN binding site [chemical binding]; other site 1254439003556 substrate binding site [chemical binding]; other site 1254439003557 putative catalytic residues [active] 1254439003558 elongation factor Tu; Reviewed; Region: PRK00049 1254439003559 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1254439003560 G1 box; other site 1254439003561 GEF interaction site [polypeptide binding]; other site 1254439003562 GTP/Mg2+ binding site [chemical binding]; other site 1254439003563 Switch I region; other site 1254439003564 G2 box; other site 1254439003565 G3 box; other site 1254439003566 Switch II region; other site 1254439003567 G4 box; other site 1254439003568 G5 box; other site 1254439003569 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1254439003570 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1254439003571 Antibiotic Binding Site [chemical binding]; other site 1254439003572 elongation factor G; Reviewed; Region: PRK00007 1254439003573 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1254439003574 G1 box; other site 1254439003575 putative GEF interaction site [polypeptide binding]; other site 1254439003576 GTP/Mg2+ binding site [chemical binding]; other site 1254439003577 Switch I region; other site 1254439003578 G2 box; other site 1254439003579 G3 box; other site 1254439003580 Switch II region; other site 1254439003581 G4 box; other site 1254439003582 G5 box; other site 1254439003583 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1254439003584 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1254439003585 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1254439003586 30S ribosomal protein S7; Validated; Region: PRK05302 1254439003587 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1254439003588 S17 interaction site [polypeptide binding]; other site 1254439003589 S8 interaction site; other site 1254439003590 16S rRNA interaction site [nucleotide binding]; other site 1254439003591 streptomycin interaction site [chemical binding]; other site 1254439003592 23S rRNA interaction site [nucleotide binding]; other site 1254439003593 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1254439003594 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1254439003595 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1254439003596 inhibitor-cofactor binding pocket; inhibition site 1254439003597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439003598 catalytic residue [active] 1254439003599 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1254439003600 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1254439003601 sulfate transport protein; Provisional; Region: cysT; CHL00187 1254439003602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439003603 dimer interface [polypeptide binding]; other site 1254439003604 conserved gate region; other site 1254439003605 putative PBP binding loops; other site 1254439003606 ABC-ATPase subunit interface; other site 1254439003607 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1254439003608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439003609 dimer interface [polypeptide binding]; other site 1254439003610 conserved gate region; other site 1254439003611 putative PBP binding loops; other site 1254439003612 ABC-ATPase subunit interface; other site 1254439003613 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1254439003614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439003615 Walker A/P-loop; other site 1254439003616 ATP binding site [chemical binding]; other site 1254439003617 Q-loop/lid; other site 1254439003618 ABC transporter signature motif; other site 1254439003619 Walker B; other site 1254439003620 D-loop; other site 1254439003621 H-loop/switch region; other site 1254439003622 TOBE domain; Region: TOBE_2; pfam08402 1254439003623 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1254439003624 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1254439003625 putative DNA binding site [nucleotide binding]; other site 1254439003626 putative Zn2+ binding site [ion binding]; other site 1254439003627 AsnC family; Region: AsnC_trans_reg; pfam01037 1254439003628 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1254439003629 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1254439003630 NAD(P) binding site [chemical binding]; other site 1254439003631 catalytic residues [active] 1254439003632 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1254439003633 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1254439003634 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1254439003635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1254439003636 ATP-grasp domain; Region: ATP-grasp; pfam02222 1254439003637 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1254439003638 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1254439003639 ATP binding site [chemical binding]; other site 1254439003640 active site 1254439003641 substrate binding site [chemical binding]; other site 1254439003642 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1254439003643 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1254439003644 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1254439003645 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1254439003646 dimerization interface [polypeptide binding]; other site 1254439003647 ATP binding site [chemical binding]; other site 1254439003648 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1254439003649 dimerization interface [polypeptide binding]; other site 1254439003650 ATP binding site [chemical binding]; other site 1254439003651 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1254439003652 putative active site [active] 1254439003653 catalytic triad [active] 1254439003654 Sec23/Sec24 zinc finger; Region: zf-Sec23_Sec24; pfam04810 1254439003655 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1254439003656 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1254439003657 Cellulose binding domain; Region: CBM_2; pfam00553 1254439003658 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1254439003659 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1254439003660 NAD binding site [chemical binding]; other site 1254439003661 homodimer interface [polypeptide binding]; other site 1254439003662 active site 1254439003663 substrate binding site [chemical binding]; other site 1254439003664 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1254439003665 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1254439003666 active site 1254439003667 tetramer interface [polypeptide binding]; other site 1254439003668 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1254439003669 active site 1254439003670 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1254439003671 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1254439003672 dimerization interface [polypeptide binding]; other site 1254439003673 putative ATP binding site [chemical binding]; other site 1254439003674 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1254439003675 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1254439003676 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1254439003677 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1254439003678 Sulfatase; Region: Sulfatase; pfam00884 1254439003679 Putative esterase; Region: Esterase; pfam00756 1254439003680 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1254439003681 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1254439003682 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1254439003683 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1254439003684 intersubunit interface [polypeptide binding]; other site 1254439003685 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1254439003686 metal binding site 2 [ion binding]; metal-binding site 1254439003687 putative DNA binding helix; other site 1254439003688 metal binding site 1 [ion binding]; metal-binding site 1254439003689 dimer interface [polypeptide binding]; other site 1254439003690 structural Zn2+ binding site [ion binding]; other site 1254439003691 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1254439003692 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1254439003693 NAD binding site [chemical binding]; other site 1254439003694 ATP-grasp domain; Region: ATP-grasp; pfam02222 1254439003695 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1254439003696 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1254439003697 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1254439003698 TPP-binding site; other site 1254439003699 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1254439003700 PYR/PP interface [polypeptide binding]; other site 1254439003701 dimer interface [polypeptide binding]; other site 1254439003702 TPP binding site [chemical binding]; other site 1254439003703 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1254439003704 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1254439003705 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1254439003706 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1254439003707 FtsX-like permease family; Region: FtsX; pfam02687 1254439003708 CARDB; Region: CARDB; pfam07705 1254439003709 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1254439003710 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1254439003711 Walker A/P-loop; other site 1254439003712 ATP binding site [chemical binding]; other site 1254439003713 Q-loop/lid; other site 1254439003714 ABC transporter signature motif; other site 1254439003715 Walker B; other site 1254439003716 D-loop; other site 1254439003717 H-loop/switch region; other site 1254439003718 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1254439003719 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1254439003720 transmembrane helices; other site 1254439003721 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1254439003722 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 1254439003723 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1254439003724 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1254439003725 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1254439003726 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1254439003727 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1254439003728 carboxyltransferase (CT) interaction site; other site 1254439003729 biotinylation site [posttranslational modification]; other site 1254439003730 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1254439003731 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1254439003732 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1254439003733 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1254439003734 putative active site [active] 1254439003735 hypothetical protein; Provisional; Region: PRK05463 1254439003736 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07849 1254439003737 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1254439003738 homodimer interface [polypeptide binding]; other site 1254439003739 substrate-cofactor binding pocket; other site 1254439003740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439003741 catalytic residue [active] 1254439003742 DNA primase, catalytic core; Region: dnaG; TIGR01391 1254439003743 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1254439003744 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1254439003745 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1254439003746 active site 1254439003747 metal binding site [ion binding]; metal-binding site 1254439003748 interdomain interaction site; other site 1254439003749 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1254439003750 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1254439003751 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1254439003752 Zn2+ binding site [ion binding]; other site 1254439003753 Mg2+ binding site [ion binding]; other site 1254439003754 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1254439003755 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1254439003756 alanine racemase; Reviewed; Region: alr; PRK00053 1254439003757 active site 1254439003758 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1254439003759 dimer interface [polypeptide binding]; other site 1254439003760 substrate binding site [chemical binding]; other site 1254439003761 catalytic residues [active] 1254439003762 amino acid transporter; Region: 2A0306; TIGR00909 1254439003763 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1254439003764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1254439003765 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1254439003766 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1254439003767 Ferritin-like domain; Region: Ferritin; pfam00210 1254439003768 ferroxidase diiron center [ion binding]; other site 1254439003769 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1254439003770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1254439003771 ATP binding site [chemical binding]; other site 1254439003772 putative Mg++ binding site [ion binding]; other site 1254439003773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1254439003774 nucleotide binding region [chemical binding]; other site 1254439003775 ATP-binding site [chemical binding]; other site 1254439003776 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1254439003777 HRDC domain; Region: HRDC; pfam00570 1254439003778 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1254439003779 cystathionine gamma-synthase; Provisional; Region: PRK07811 1254439003780 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1254439003781 homodimer interface [polypeptide binding]; other site 1254439003782 substrate-cofactor binding pocket; other site 1254439003783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439003784 catalytic residue [active] 1254439003785 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1254439003786 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1254439003787 dimer interface [polypeptide binding]; other site 1254439003788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439003789 catalytic residue [active] 1254439003790 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1254439003791 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1254439003792 dimerization interface [polypeptide binding]; other site 1254439003793 NAD binding site [chemical binding]; other site 1254439003794 ligand binding site [chemical binding]; other site 1254439003795 catalytic site [active] 1254439003796 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1254439003797 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1254439003798 Walker A/P-loop; other site 1254439003799 ATP binding site [chemical binding]; other site 1254439003800 Q-loop/lid; other site 1254439003801 ABC transporter signature motif; other site 1254439003802 Walker B; other site 1254439003803 D-loop; other site 1254439003804 H-loop/switch region; other site 1254439003805 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1254439003806 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1254439003807 Walker A/P-loop; other site 1254439003808 ATP binding site [chemical binding]; other site 1254439003809 Q-loop/lid; other site 1254439003810 ABC transporter signature motif; other site 1254439003811 Walker B; other site 1254439003812 D-loop; other site 1254439003813 H-loop/switch region; other site 1254439003814 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1254439003815 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1254439003816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1254439003817 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1254439003818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439003819 dimer interface [polypeptide binding]; other site 1254439003820 conserved gate region; other site 1254439003821 putative PBP binding loops; other site 1254439003822 ABC-ATPase subunit interface; other site 1254439003823 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1254439003824 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1254439003825 pantothenate kinase; Reviewed; Region: PRK13318 1254439003826 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1254439003827 Flavoprotein; Region: Flavoprotein; pfam02441 1254439003828 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1254439003829 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1254439003830 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1254439003831 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1254439003832 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1254439003833 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1254439003834 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439003835 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1254439003836 DNA binding site [nucleotide binding] 1254439003837 domain linker motif; other site 1254439003838 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1254439003839 ligand binding site [chemical binding]; other site 1254439003840 dimerization interface (open form) [polypeptide binding]; other site 1254439003841 dimerization interface (closed form) [polypeptide binding]; other site 1254439003842 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1254439003843 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1254439003844 active site 1254439003845 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1254439003846 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1254439003847 glutaminase active site [active] 1254439003848 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1254439003849 dimer interface [polypeptide binding]; other site 1254439003850 active site 1254439003851 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1254439003852 dimer interface [polypeptide binding]; other site 1254439003853 active site 1254439003854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439003855 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1254439003856 Walker A/P-loop; other site 1254439003857 ATP binding site [chemical binding]; other site 1254439003858 Q-loop/lid; other site 1254439003859 ABC transporter signature motif; other site 1254439003860 Walker B; other site 1254439003861 D-loop; other site 1254439003862 H-loop/switch region; other site 1254439003863 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1254439003864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1254439003865 active site 1254439003866 phosphorylation site [posttranslational modification] 1254439003867 intermolecular recognition site; other site 1254439003868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1254439003869 DNA binding residues [nucleotide binding] 1254439003870 dimerization interface [polypeptide binding]; other site 1254439003871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1254439003872 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1254439003873 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1254439003874 Walker A/P-loop; other site 1254439003875 ATP binding site [chemical binding]; other site 1254439003876 Q-loop/lid; other site 1254439003877 ABC transporter signature motif; other site 1254439003878 Walker B; other site 1254439003879 D-loop; other site 1254439003880 H-loop/switch region; other site 1254439003881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439003882 dimer interface [polypeptide binding]; other site 1254439003883 conserved gate region; other site 1254439003884 putative PBP binding loops; other site 1254439003885 ABC-ATPase subunit interface; other site 1254439003886 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1254439003887 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1254439003888 substrate binding pocket [chemical binding]; other site 1254439003889 membrane-bound complex binding site; other site 1254439003890 hinge residues; other site 1254439003891 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1254439003892 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1254439003893 substrate binding pocket [chemical binding]; other site 1254439003894 membrane-bound complex binding site; other site 1254439003895 hinge residues; other site 1254439003896 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1254439003897 SmpB-tmRNA interface; other site 1254439003898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1254439003899 CHAP domain; Region: CHAP; pfam05257 1254439003900 Surface antigen [General function prediction only]; Region: COG3942 1254439003901 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1254439003902 FtsX-like permease family; Region: FtsX; pfam02687 1254439003903 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1254439003904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439003905 Walker A/P-loop; other site 1254439003906 ATP binding site [chemical binding]; other site 1254439003907 Q-loop/lid; other site 1254439003908 ABC transporter signature motif; other site 1254439003909 Walker B; other site 1254439003910 D-loop; other site 1254439003911 H-loop/switch region; other site 1254439003912 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1254439003913 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1254439003914 RF-1 domain; Region: RF-1; pfam00472 1254439003915 Pleckstrin homology-like domain; Region: PH-like; cl17171 1254439003916 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1254439003917 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1254439003918 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1254439003919 putative trimer interface [polypeptide binding]; other site 1254439003920 putative CoA binding site [chemical binding]; other site 1254439003921 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1254439003922 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1254439003923 Citrate synthase; Region: Citrate_synt; pfam00285 1254439003924 oxalacetate binding site [chemical binding]; other site 1254439003925 citrylCoA binding site [chemical binding]; other site 1254439003926 coenzyme A binding site [chemical binding]; other site 1254439003927 catalytic triad [active] 1254439003928 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1254439003929 active site 1254439003930 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1254439003931 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1254439003932 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1254439003933 active site 1254439003934 Zn binding site [ion binding]; other site 1254439003935 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1254439003936 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1254439003937 dimer interface [polypeptide binding]; other site 1254439003938 ssDNA binding site [nucleotide binding]; other site 1254439003939 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1254439003940 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1254439003941 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1254439003942 dimer interface [polypeptide binding]; other site 1254439003943 motif 1; other site 1254439003944 active site 1254439003945 motif 2; other site 1254439003946 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1254439003947 putative deacylase active site [active] 1254439003948 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1254439003949 active site 1254439003950 motif 3; other site 1254439003951 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1254439003952 anticodon binding site; other site 1254439003953 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1254439003954 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1254439003955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439003956 dimer interface [polypeptide binding]; other site 1254439003957 conserved gate region; other site 1254439003958 ABC-ATPase subunit interface; other site 1254439003959 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1254439003960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439003961 dimer interface [polypeptide binding]; other site 1254439003962 conserved gate region; other site 1254439003963 putative PBP binding loops; other site 1254439003964 ABC-ATPase subunit interface; other site 1254439003965 Protein of unknown function, DUF624; Region: DUF624; cl02369 1254439003966 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439003967 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1254439003968 DNA binding site [nucleotide binding] 1254439003969 domain linker motif; other site 1254439003970 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1254439003971 putative dimerization interface [polypeptide binding]; other site 1254439003972 putative ligand binding site [chemical binding]; other site 1254439003973 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1254439003974 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1254439003975 substrate binding [chemical binding]; other site 1254439003976 active site 1254439003977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439003978 PIF1-like helicase; Region: PIF1; pfam05970 1254439003979 Walker A motif; other site 1254439003980 ATP binding site [chemical binding]; other site 1254439003981 Walker B motif; other site 1254439003982 arginine finger; other site 1254439003983 Family description; Region: UvrD_C_2; pfam13538 1254439003984 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1254439003985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439003986 active site 1254439003987 motif I; other site 1254439003988 motif II; other site 1254439003989 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1254439003990 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1254439003991 catalytic site [active] 1254439003992 putative active site [active] 1254439003993 putative substrate binding site [chemical binding]; other site 1254439003994 dimer interface [polypeptide binding]; other site 1254439003995 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1254439003996 Na binding site [ion binding]; other site 1254439003997 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1254439003998 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1254439003999 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1254439004000 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1254439004001 active site 1254439004002 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1254439004003 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1254439004004 Mg++ binding site [ion binding]; other site 1254439004005 putative catalytic motif [active] 1254439004006 substrate binding site [chemical binding]; other site 1254439004007 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1254439004008 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1254439004009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1254439004010 S-adenosylmethionine binding site [chemical binding]; other site 1254439004011 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1254439004012 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1254439004013 RF-1 domain; Region: RF-1; pfam00472 1254439004014 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1254439004015 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1254439004016 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1254439004017 Sodium Bile acid symporter family; Region: SBF; pfam01758 1254439004018 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1254439004019 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1254439004020 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1254439004021 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1254439004022 aminotransferase; Validated; Region: PRK07337 1254439004023 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1254439004024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439004025 homodimer interface [polypeptide binding]; other site 1254439004026 catalytic residue [active] 1254439004027 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1254439004028 mismatch recognition site; other site 1254439004029 additional DNA contacts [nucleotide binding]; other site 1254439004030 active site 1254439004031 zinc binding site [ion binding]; other site 1254439004032 DNA intercalation site [nucleotide binding]; other site 1254439004033 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1254439004034 nudix motif; other site 1254439004035 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1254439004036 quinolinate synthetase; Provisional; Region: PRK09375 1254439004037 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1254439004038 L-aspartate oxidase; Provisional; Region: PRK06175 1254439004039 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1254439004040 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 1254439004041 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1254439004042 dimerization interface [polypeptide binding]; other site 1254439004043 active site 1254439004044 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1254439004045 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1254439004046 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1254439004047 catalytic residue [active] 1254439004048 recombination factor protein RarA; Reviewed; Region: PRK13342 1254439004049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439004050 Walker A motif; other site 1254439004051 ATP binding site [chemical binding]; other site 1254439004052 Walker B motif; other site 1254439004053 arginine finger; other site 1254439004054 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1254439004055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439004056 ABC-ATPase subunit interface; other site 1254439004057 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1254439004058 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1254439004059 Walker A/P-loop; other site 1254439004060 ATP binding site [chemical binding]; other site 1254439004061 Q-loop/lid; other site 1254439004062 ABC transporter signature motif; other site 1254439004063 Walker B; other site 1254439004064 D-loop; other site 1254439004065 H-loop/switch region; other site 1254439004066 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1254439004067 NIL domain; Region: NIL; pfam09383 1254439004068 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1254439004069 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1254439004070 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1254439004071 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1254439004072 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1254439004073 transaminase; Reviewed; Region: PRK08068 1254439004074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1254439004075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439004076 homodimer interface [polypeptide binding]; other site 1254439004077 catalytic residue [active] 1254439004078 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1254439004079 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1254439004080 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1254439004081 active site 1254439004082 8-oxo-dGMP binding site [chemical binding]; other site 1254439004083 nudix motif; other site 1254439004084 metal binding site [ion binding]; metal-binding site 1254439004085 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1254439004086 PLD-like domain; Region: PLDc_2; pfam13091 1254439004087 putative homodimer interface [polypeptide binding]; other site 1254439004088 putative active site [active] 1254439004089 catalytic site [active] 1254439004090 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1254439004091 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1254439004092 ATP binding site [chemical binding]; other site 1254439004093 putative Mg++ binding site [ion binding]; other site 1254439004094 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1254439004095 nucleotide binding region [chemical binding]; other site 1254439004096 ATP-binding site [chemical binding]; other site 1254439004097 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1254439004098 Protein of unknown function DUF262; Region: DUF262; pfam03235 1254439004099 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1254439004100 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1254439004101 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1254439004102 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1254439004103 AAA domain; Region: AAA_14; pfam13173 1254439004104 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1254439004105 SWIM zinc finger; Region: SWIM; pfam04434 1254439004106 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1254439004107 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1254439004108 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1254439004109 ATP binding site [chemical binding]; other site 1254439004110 putative Mg++ binding site [ion binding]; other site 1254439004111 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1254439004112 nucleotide binding region [chemical binding]; other site 1254439004113 ATP-binding site [chemical binding]; other site 1254439004114 helicase 45; Provisional; Region: PTZ00424 1254439004115 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1254439004116 ATP binding site [chemical binding]; other site 1254439004117 Mg++ binding site [ion binding]; other site 1254439004118 motif III; other site 1254439004119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1254439004120 nucleotide binding region [chemical binding]; other site 1254439004121 ATP-binding site [chemical binding]; other site 1254439004122 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1254439004123 hypothetical protein; Provisional; Region: PRK10621 1254439004124 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1254439004125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439004126 Walker A/P-loop; other site 1254439004127 ATP binding site [chemical binding]; other site 1254439004128 Q-loop/lid; other site 1254439004129 ABC transporter signature motif; other site 1254439004130 Walker B; other site 1254439004131 D-loop; other site 1254439004132 H-loop/switch region; other site 1254439004133 ABC transporter; Region: ABC_tran_2; pfam12848 1254439004134 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1254439004135 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1254439004136 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1254439004137 active site 1254439004138 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1254439004139 catalytic triad [active] 1254439004140 dimer interface [polypeptide binding]; other site 1254439004141 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1254439004142 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1254439004143 homooctamer interface [polypeptide binding]; other site 1254439004144 active site 1254439004145 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1254439004146 catalytic center binding site [active] 1254439004147 ATP binding site [chemical binding]; other site 1254439004148 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1254439004149 dihydropteroate synthase; Region: DHPS; TIGR01496 1254439004150 substrate binding pocket [chemical binding]; other site 1254439004151 dimer interface [polypeptide binding]; other site 1254439004152 inhibitor binding site; inhibition site 1254439004153 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1254439004154 GTP cyclohydrolase I; Provisional; Region: PLN03044 1254439004155 active site 1254439004156 Dihydroneopterin aldolase; Region: FolB; pfam02152 1254439004157 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1254439004158 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1254439004159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439004160 Walker A motif; other site 1254439004161 ATP binding site [chemical binding]; other site 1254439004162 Walker B motif; other site 1254439004163 arginine finger; other site 1254439004164 Peptidase family M41; Region: Peptidase_M41; pfam01434 1254439004165 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1254439004166 active site 1254439004167 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1254439004168 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1254439004169 Ligand Binding Site [chemical binding]; other site 1254439004170 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1254439004171 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1254439004172 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1254439004173 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1254439004174 DXD motif; other site 1254439004175 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1254439004176 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1254439004177 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1254439004178 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1254439004179 active site 1254439004180 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1254439004181 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1254439004182 dimer interface [polypeptide binding]; other site 1254439004183 active site 1254439004184 metal binding site [ion binding]; metal-binding site 1254439004185 WYL domain; Region: WYL; pfam13280 1254439004186 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1254439004187 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1254439004188 homodimer interface [polypeptide binding]; other site 1254439004189 maltodextrin glucosidase; Provisional; Region: PRK10785 1254439004190 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1254439004191 active site 1254439004192 homodimer interface [polypeptide binding]; other site 1254439004193 catalytic site [active] 1254439004194 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1254439004195 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1254439004196 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1254439004197 active site 1254439004198 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1254439004199 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1254439004200 folate binding site [chemical binding]; other site 1254439004201 NADP+ binding site [chemical binding]; other site 1254439004202 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1254439004203 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1254439004204 dimerization interface [polypeptide binding]; other site 1254439004205 active site 1254439004206 OsmC-like protein; Region: OsmC; pfam02566 1254439004207 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1254439004208 Ligand Binding Site [chemical binding]; other site 1254439004209 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1254439004210 Ligand Binding Site [chemical binding]; other site 1254439004211 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1254439004212 NlpC/P60 family; Region: NLPC_P60; pfam00877 1254439004213 CHAP domain; Region: CHAP; pfam05257 1254439004214 phosphoserine aminotransferase; Provisional; Region: PRK03080 1254439004215 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1254439004216 catalytic residue [active] 1254439004217 mannose-6-phosphate isomerase; Region: PLN02288 1254439004218 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1254439004219 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1254439004220 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1254439004221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1254439004222 ATP binding site [chemical binding]; other site 1254439004223 Mg2+ binding site [ion binding]; other site 1254439004224 G-X-G motif; other site 1254439004225 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1254439004226 PhoU domain; Region: PhoU; pfam01895 1254439004227 PhoU domain; Region: PhoU; pfam01895 1254439004228 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1254439004229 catalytic core [active] 1254439004230 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1254439004231 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1254439004232 UbiA prenyltransferase family; Region: UbiA; pfam01040 1254439004233 Archaeal ATPase; Region: Arch_ATPase; pfam01637 1254439004234 AAA ATPase domain; Region: AAA_16; pfam13191 1254439004235 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1254439004236 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 1254439004237 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1254439004238 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1254439004239 dimer interface [polypeptide binding]; other site 1254439004240 putative anticodon binding site; other site 1254439004241 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1254439004242 motif 1; other site 1254439004243 dimer interface [polypeptide binding]; other site 1254439004244 active site 1254439004245 motif 2; other site 1254439004246 motif 3; other site 1254439004247 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1254439004248 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1254439004249 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1254439004250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1254439004251 binding surface 1254439004252 TPR motif; other site 1254439004253 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1254439004254 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 1254439004255 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1254439004256 PspC domain; Region: PspC; pfam04024 1254439004257 PspC domain; Region: PspC; pfam04024 1254439004258 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1254439004259 ATP binding site [chemical binding]; other site 1254439004260 Mg2+ binding site [ion binding]; other site 1254439004261 G-X-G motif; other site 1254439004262 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1254439004263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1254439004264 active site 1254439004265 phosphorylation site [posttranslational modification] 1254439004266 intermolecular recognition site; other site 1254439004267 dimerization interface [polypeptide binding]; other site 1254439004268 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1254439004269 DNA binding residues [nucleotide binding] 1254439004270 dimerization interface [polypeptide binding]; other site 1254439004271 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1254439004272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439004273 motif II; other site 1254439004274 seryl-tRNA synthetase; Provisional; Region: PRK05431 1254439004275 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1254439004276 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1254439004277 dimer interface [polypeptide binding]; other site 1254439004278 active site 1254439004279 motif 1; other site 1254439004280 motif 2; other site 1254439004281 motif 3; other site 1254439004282 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1254439004283 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1254439004284 PRD domain; Region: PRD; pfam00874 1254439004285 PRD domain; Region: PRD; pfam00874 1254439004286 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1254439004287 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1254439004288 active site turn [active] 1254439004289 phosphorylation site [posttranslational modification] 1254439004290 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1254439004291 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1254439004292 HPr interaction site; other site 1254439004293 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1254439004294 active site 1254439004295 phosphorylation site [posttranslational modification] 1254439004296 phosphoglucomutase; Validated; Region: PRK07564 1254439004297 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1254439004298 active site 1254439004299 substrate binding site [chemical binding]; other site 1254439004300 metal binding site [ion binding]; metal-binding site 1254439004301 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1254439004302 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1254439004303 Na binding site [ion binding]; other site 1254439004304 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1254439004305 Phosphotransferase enzyme family; Region: APH; pfam01636 1254439004306 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 1254439004307 active site 1254439004308 ATP binding site [chemical binding]; other site 1254439004309 substrate binding site [chemical binding]; other site 1254439004310 dimer interface [polypeptide binding]; other site 1254439004311 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1254439004312 amidase; Provisional; Region: PRK07042 1254439004313 Amidase; Region: Amidase; cl11426 1254439004314 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1254439004315 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1254439004316 inhibitor-cofactor binding pocket; inhibition site 1254439004317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439004318 catalytic residue [active] 1254439004319 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1254439004320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1254439004321 DNA-binding site [nucleotide binding]; DNA binding site 1254439004322 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1254439004323 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1254439004324 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1254439004325 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1254439004326 DNA binding residues [nucleotide binding] 1254439004327 putative dimer interface [polypeptide binding]; other site 1254439004328 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1254439004329 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1254439004330 catalytic Zn binding site [ion binding]; other site 1254439004331 NAD(P) binding site [chemical binding]; other site 1254439004332 structural Zn binding site [ion binding]; other site 1254439004333 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1254439004334 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1254439004335 proline racemase; Provisional; Region: PRK13969 1254439004336 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1254439004337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1254439004338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1254439004339 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 1254439004340 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 1254439004341 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1254439004342 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1254439004343 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1254439004344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439004345 dimer interface [polypeptide binding]; other site 1254439004346 conserved gate region; other site 1254439004347 ABC-ATPase subunit interface; other site 1254439004348 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1254439004349 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1254439004350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439004351 dimer interface [polypeptide binding]; other site 1254439004352 conserved gate region; other site 1254439004353 putative PBP binding loops; other site 1254439004354 ABC-ATPase subunit interface; other site 1254439004355 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1254439004356 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1254439004357 Walker A/P-loop; other site 1254439004358 ATP binding site [chemical binding]; other site 1254439004359 Q-loop/lid; other site 1254439004360 ABC transporter signature motif; other site 1254439004361 Walker B; other site 1254439004362 D-loop; other site 1254439004363 H-loop/switch region; other site 1254439004364 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1254439004365 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1254439004366 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1254439004367 Walker A/P-loop; other site 1254439004368 ATP binding site [chemical binding]; other site 1254439004369 Q-loop/lid; other site 1254439004370 ABC transporter signature motif; other site 1254439004371 Walker B; other site 1254439004372 D-loop; other site 1254439004373 H-loop/switch region; other site 1254439004374 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 1254439004375 peptide binding site [polypeptide binding]; other site 1254439004376 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1254439004377 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1254439004378 RNA/DNA hybrid binding site [nucleotide binding]; other site 1254439004379 active site 1254439004380 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1254439004381 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1254439004382 active site 1254439004383 dimer interface [polypeptide binding]; other site 1254439004384 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1254439004385 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1254439004386 homodimer interface [polypeptide binding]; other site 1254439004387 substrate-cofactor binding pocket; other site 1254439004388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439004389 catalytic residue [active] 1254439004390 DNA repair protein RadA; Provisional; Region: PRK11823 1254439004391 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1254439004392 Walker A motif; other site 1254439004393 ATP binding site [chemical binding]; other site 1254439004394 Walker B motif; other site 1254439004395 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1254439004396 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1254439004397 active site 1254439004398 Riboflavin kinase; Region: Flavokinase; smart00904 1254439004399 Riboflavin kinase; Region: Flavokinase; cl03312 1254439004400 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1254439004401 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1254439004402 RNA binding site [nucleotide binding]; other site 1254439004403 active site 1254439004404 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1254439004405 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1254439004406 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1254439004407 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1254439004408 G1 box; other site 1254439004409 putative GEF interaction site [polypeptide binding]; other site 1254439004410 GTP/Mg2+ binding site [chemical binding]; other site 1254439004411 Switch I region; other site 1254439004412 G2 box; other site 1254439004413 G3 box; other site 1254439004414 Switch II region; other site 1254439004415 G4 box; other site 1254439004416 G5 box; other site 1254439004417 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1254439004418 Translation-initiation factor 2; Region: IF-2; pfam11987 1254439004419 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1254439004420 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1254439004421 NusA N-terminal domain; Region: NusA_N; pfam08529 1254439004422 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1254439004423 RNA binding site [nucleotide binding]; other site 1254439004424 homodimer interface [polypeptide binding]; other site 1254439004425 NusA-like KH domain; Region: KH_5; pfam13184 1254439004426 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1254439004427 G-X-X-G motif; other site 1254439004428 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1254439004429 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1254439004430 dimerization interface 3.5A [polypeptide binding]; other site 1254439004431 active site 1254439004432 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1254439004433 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1254439004434 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1254439004435 alphaNTD homodimer interface [polypeptide binding]; other site 1254439004436 alphaNTD - beta interaction site [polypeptide binding]; other site 1254439004437 alphaNTD - beta' interaction site [polypeptide binding]; other site 1254439004438 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1254439004439 30S ribosomal protein S11; Validated; Region: PRK05309 1254439004440 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1254439004441 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1254439004442 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1254439004443 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1254439004444 rRNA binding site [nucleotide binding]; other site 1254439004445 predicted 30S ribosome binding site; other site 1254439004446 adenylate kinase; Reviewed; Region: adk; PRK00279 1254439004447 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1254439004448 AMP-binding site [chemical binding]; other site 1254439004449 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1254439004450 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1254439004451 SecY translocase; Region: SecY; pfam00344 1254439004452 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1254439004453 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1254439004454 23S rRNA binding site [nucleotide binding]; other site 1254439004455 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1254439004456 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1254439004457 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1254439004458 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1254439004459 23S rRNA interface [nucleotide binding]; other site 1254439004460 5S rRNA interface [nucleotide binding]; other site 1254439004461 L27 interface [polypeptide binding]; other site 1254439004462 L5 interface [polypeptide binding]; other site 1254439004463 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1254439004464 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1254439004465 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1254439004466 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1254439004467 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1254439004468 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1254439004469 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1254439004470 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1254439004471 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1254439004472 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1254439004473 RNA binding site [nucleotide binding]; other site 1254439004474 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1254439004475 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1254439004476 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1254439004477 23S rRNA interface [nucleotide binding]; other site 1254439004478 putative translocon interaction site; other site 1254439004479 signal recognition particle (SRP54) interaction site; other site 1254439004480 L23 interface [polypeptide binding]; other site 1254439004481 trigger factor interaction site; other site 1254439004482 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1254439004483 23S rRNA interface [nucleotide binding]; other site 1254439004484 5S rRNA interface [nucleotide binding]; other site 1254439004485 putative antibiotic binding site [chemical binding]; other site 1254439004486 L25 interface [polypeptide binding]; other site 1254439004487 L27 interface [polypeptide binding]; other site 1254439004488 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1254439004489 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1254439004490 G-X-X-G motif; other site 1254439004491 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1254439004492 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1254439004493 putative translocon binding site; other site 1254439004494 protein-rRNA interface [nucleotide binding]; other site 1254439004495 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1254439004496 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1254439004497 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1254439004498 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1254439004499 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1254439004500 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1254439004501 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1254439004502 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1254439004503 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1254439004504 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1254439004505 substrate binding pocket [chemical binding]; other site 1254439004506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1254439004507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1254439004508 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1254439004509 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1254439004510 putative catalytic cysteine [active] 1254439004511 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1254439004512 putative active site [active] 1254439004513 metal binding site [ion binding]; metal-binding site 1254439004514 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1254439004515 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1254439004516 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1254439004517 active site 1254439004518 catalytic site [active] 1254439004519 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1254439004520 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1254439004521 23S rRNA interface [nucleotide binding]; other site 1254439004522 L3 interface [polypeptide binding]; other site 1254439004523 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1254439004524 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1254439004525 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1254439004526 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1254439004527 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1254439004528 active site 1254439004529 DNA polymerase IV; Validated; Region: PRK02406 1254439004530 DNA binding site [nucleotide binding] 1254439004531 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1254439004532 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1254439004533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439004534 homodimer interface [polypeptide binding]; other site 1254439004535 catalytic residue [active] 1254439004536 Ferredoxin [Energy production and conversion]; Region: COG1146 1254439004537 4Fe-4S binding domain; Region: Fer4; pfam00037 1254439004538 amino acid transporter; Region: 2A0306; TIGR00909 1254439004539 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1254439004540 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1254439004541 FAD binding domain; Region: FAD_binding_4; pfam01565 1254439004542 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1254439004543 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1254439004544 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1254439004545 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1254439004546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439004547 homodimer interface [polypeptide binding]; other site 1254439004548 catalytic residue [active] 1254439004549 Protein of unknown function DUF58; Region: DUF58; pfam01882 1254439004550 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1254439004551 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1254439004552 MoxR-like ATPases [General function prediction only]; Region: COG0714 1254439004553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439004554 Walker A motif; other site 1254439004555 ATP binding site [chemical binding]; other site 1254439004556 Walker B motif; other site 1254439004557 arginine finger; other site 1254439004558 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1254439004559 oligomerisation interface [polypeptide binding]; other site 1254439004560 mobile loop; other site 1254439004561 roof hairpin; other site 1254439004562 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1254439004563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1254439004564 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1254439004565 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1254439004566 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1254439004567 DNA-directed RNA polymerase subunit A'; Validated; Region: PRK08566 1254439004568 Part of AAA domain; Region: AAA_19; pfam13245 1254439004569 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1254439004570 phosphopeptide binding site; other site 1254439004571 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1254439004572 core dimer interface [polypeptide binding]; other site 1254439004573 peripheral dimer interface [polypeptide binding]; other site 1254439004574 L10 interface [polypeptide binding]; other site 1254439004575 L11 interface [polypeptide binding]; other site 1254439004576 putative EF-Tu interaction site [polypeptide binding]; other site 1254439004577 putative EF-G interaction site [polypeptide binding]; other site 1254439004578 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1254439004579 23S rRNA interface [nucleotide binding]; other site 1254439004580 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1254439004581 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1254439004582 active site 1254439004583 catalytic site [active] 1254439004584 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1254439004585 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1254439004586 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1254439004587 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1254439004588 Walker A/P-loop; other site 1254439004589 ATP binding site [chemical binding]; other site 1254439004590 Q-loop/lid; other site 1254439004591 ABC transporter signature motif; other site 1254439004592 Walker B; other site 1254439004593 D-loop; other site 1254439004594 H-loop/switch region; other site 1254439004595 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1254439004596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439004597 dimer interface [polypeptide binding]; other site 1254439004598 conserved gate region; other site 1254439004599 putative PBP binding loops; other site 1254439004600 ABC-ATPase subunit interface; other site 1254439004601 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1254439004602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439004603 dimer interface [polypeptide binding]; other site 1254439004604 conserved gate region; other site 1254439004605 putative PBP binding loops; other site 1254439004606 ABC-ATPase subunit interface; other site 1254439004607 PBP superfamily domain; Region: PBP_like_2; cl17296 1254439004608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1254439004609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1254439004610 active site 1254439004611 phosphorylation site [posttranslational modification] 1254439004612 intermolecular recognition site; other site 1254439004613 dimerization interface [polypeptide binding]; other site 1254439004614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1254439004615 DNA binding site [nucleotide binding] 1254439004616 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1254439004617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1254439004618 dimer interface [polypeptide binding]; other site 1254439004619 phosphorylation site [posttranslational modification] 1254439004620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1254439004621 ATP binding site [chemical binding]; other site 1254439004622 Mg2+ binding site [ion binding]; other site 1254439004623 G-X-G motif; other site 1254439004624 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1254439004625 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1254439004626 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1254439004627 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1254439004628 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1254439004629 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1254439004630 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1254439004631 trimer interface [polypeptide binding]; other site 1254439004632 active site 1254439004633 G bulge; other site 1254439004634 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1254439004635 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1254439004636 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1254439004637 putative substrate binding pocket [chemical binding]; other site 1254439004638 AC domain interface; other site 1254439004639 catalytic triad [active] 1254439004640 AB domain interface; other site 1254439004641 interchain disulfide; other site 1254439004642 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1254439004643 substrate binding site; other site 1254439004644 dimer interface; other site 1254439004645 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1254439004646 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1254439004647 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1254439004648 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1254439004649 Peptidase family U32; Region: Peptidase_U32; pfam01136 1254439004650 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1254439004651 active site 1254439004652 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1254439004653 catalytic tetrad [active] 1254439004654 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1254439004655 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1254439004656 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1254439004657 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1254439004658 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1254439004659 oligomer interface [polypeptide binding]; other site 1254439004660 RNA binding site [nucleotide binding]; other site 1254439004661 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1254439004662 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1254439004663 RNase E interface [polypeptide binding]; other site 1254439004664 trimer interface [polypeptide binding]; other site 1254439004665 active site 1254439004666 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1254439004667 putative nucleic acid binding region [nucleotide binding]; other site 1254439004668 G-X-X-G motif; other site 1254439004669 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1254439004670 RNA binding site [nucleotide binding]; other site 1254439004671 domain interface; other site 1254439004672 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1254439004673 16S/18S rRNA binding site [nucleotide binding]; other site 1254439004674 S13e-L30e interaction site [polypeptide binding]; other site 1254439004675 25S rRNA binding site [nucleotide binding]; other site 1254439004676 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 1254439004677 trehalose synthase; Region: treS_nterm; TIGR02456 1254439004678 active site 1254439004679 catalytic site [active] 1254439004680 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 1254439004681 CAAX protease self-immunity; Region: Abi; pfam02517 1254439004682 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1254439004683 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1254439004684 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1254439004685 phosphate binding site [ion binding]; other site 1254439004686 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1254439004687 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1254439004688 active site 2 [active] 1254439004689 active site 1 [active] 1254439004690 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1254439004691 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1254439004692 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1254439004693 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1254439004694 putative NAD(P) binding site [chemical binding]; other site 1254439004695 active site 1254439004696 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1254439004697 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1254439004698 active site 1254439004699 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1254439004700 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1254439004701 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1254439004702 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1254439004703 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1254439004704 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1254439004705 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1254439004706 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1254439004707 carboxyltransferase (CT) interaction site; other site 1254439004708 biotinylation site [posttranslational modification]; other site 1254439004709 BioY family; Region: BioY; pfam02632 1254439004710 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1254439004711 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1254439004712 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1254439004713 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1254439004714 mRNA/rRNA interface [nucleotide binding]; other site 1254439004715 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1254439004716 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1254439004717 23S rRNA interface [nucleotide binding]; other site 1254439004718 L7/L12 interface [polypeptide binding]; other site 1254439004719 putative thiostrepton binding site; other site 1254439004720 L25 interface [polypeptide binding]; other site 1254439004721 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1254439004722 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1254439004723 putative homodimer interface [polypeptide binding]; other site 1254439004724 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1254439004725 heterodimer interface [polypeptide binding]; other site 1254439004726 homodimer interface [polypeptide binding]; other site 1254439004727 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1254439004728 aspartate aminotransferase; Provisional; Region: PRK05764 1254439004729 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1254439004730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439004731 homodimer interface [polypeptide binding]; other site 1254439004732 catalytic residue [active] 1254439004733 gamma-glutamyl kinase; Provisional; Region: PRK05429 1254439004734 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1254439004735 nucleotide binding site [chemical binding]; other site 1254439004736 homotetrameric interface [polypeptide binding]; other site 1254439004737 putative phosphate binding site [ion binding]; other site 1254439004738 putative allosteric binding site; other site 1254439004739 PUA domain; Region: PUA; pfam01472 1254439004740 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1254439004741 GTP1/OBG; Region: GTP1_OBG; pfam01018 1254439004742 Obg GTPase; Region: Obg; cd01898 1254439004743 G1 box; other site 1254439004744 GTP/Mg2+ binding site [chemical binding]; other site 1254439004745 Switch I region; other site 1254439004746 G2 box; other site 1254439004747 G3 box; other site 1254439004748 Switch II region; other site 1254439004749 G4 box; other site 1254439004750 G5 box; other site 1254439004751 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1254439004752 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1254439004753 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1254439004754 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1254439004755 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1254439004756 homodimer interface [polypeptide binding]; other site 1254439004757 oligonucleotide binding site [chemical binding]; other site 1254439004758 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1254439004759 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1254439004760 metal binding site [ion binding]; metal-binding site 1254439004761 putative dimer interface [polypeptide binding]; other site 1254439004762 Predicted permeases [General function prediction only]; Region: COG0679 1254439004763 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1254439004764 putative active site [active] 1254439004765 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1254439004766 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1254439004767 nudix motif; other site 1254439004768 homoserine kinase; Provisional; Region: PRK01212 1254439004769 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1254439004770 homoserine dehydrogenase; Provisional; Region: PRK06349 1254439004771 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1254439004772 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1254439004773 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1254439004774 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1254439004775 catalytic residue [active] 1254439004776 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1254439004777 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1254439004778 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1254439004779 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1254439004780 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1254439004781 active site 1254439004782 HIGH motif; other site 1254439004783 nucleotide binding site [chemical binding]; other site 1254439004784 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1254439004785 KMSK motif region; other site 1254439004786 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1254439004787 tRNA binding surface [nucleotide binding]; other site 1254439004788 anticodon binding site; other site 1254439004789 S-methylmethionine transporter; Provisional; Region: PRK11387 1254439004790 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1254439004791 homotrimer interaction site [polypeptide binding]; other site 1254439004792 putative active site [active] 1254439004793 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 1254439004794 MULE transposase domain; Region: MULE; pfam10551 1254439004795 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1254439004796 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1254439004797 Utp8 family; Region: Utp8; pfam10395 1254439004798 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1254439004799 hypothetical protein; Provisional; Region: PRK03298 1254439004800 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1254439004801 gamma subunit interface [polypeptide binding]; other site 1254439004802 epsilon subunit interface [polypeptide binding]; other site 1254439004803 LBP interface [polypeptide binding]; other site 1254439004804 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1254439004805 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1254439004806 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1254439004807 alpha subunit interaction interface [polypeptide binding]; other site 1254439004808 Walker A motif; other site 1254439004809 ATP binding site [chemical binding]; other site 1254439004810 Walker B motif; other site 1254439004811 inhibitor binding site; inhibition site 1254439004812 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1254439004813 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1254439004814 core domain interface [polypeptide binding]; other site 1254439004815 delta subunit interface [polypeptide binding]; other site 1254439004816 epsilon subunit interface [polypeptide binding]; other site 1254439004817 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1254439004818 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1254439004819 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1254439004820 beta subunit interaction interface [polypeptide binding]; other site 1254439004821 Walker A motif; other site 1254439004822 ATP binding site [chemical binding]; other site 1254439004823 Walker B motif; other site 1254439004824 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1254439004825 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1254439004826 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1254439004827 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1254439004828 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1254439004829 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1254439004830 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1254439004831 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1254439004832 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1254439004833 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1254439004834 proposed active site lysine [active] 1254439004835 conserved cys residue [active] 1254439004836 MULE transposase domain; Region: MULE; pfam10551 1254439004837 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1254439004838 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1254439004839 active site 1254439004840 homodimer interface [polypeptide binding]; other site 1254439004841 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1254439004842 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1254439004843 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1254439004844 active site 1254439004845 catalytic site [active] 1254439004846 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1254439004847 dimer interface [polypeptide binding]; other site 1254439004848 substrate binding site [chemical binding]; other site 1254439004849 metal binding sites [ion binding]; metal-binding site 1254439004850 Predicted membrane protein [Function unknown]; Region: COG1971 1254439004851 Domain of unknown function DUF; Region: DUF204; pfam02659 1254439004852 Domain of unknown function DUF; Region: DUF204; pfam02659 1254439004853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1254439004854 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1254439004855 DNA binding site [nucleotide binding] 1254439004856 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1254439004857 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1254439004858 minor groove reading motif; other site 1254439004859 helix-hairpin-helix signature motif; other site 1254439004860 substrate binding pocket [chemical binding]; other site 1254439004861 active site 1254439004862 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1254439004863 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1254439004864 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1254439004865 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1254439004866 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1254439004867 active site 1254439004868 HIGH motif; other site 1254439004869 nucleotide binding site [chemical binding]; other site 1254439004870 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1254439004871 active site 1254439004872 KMSKS motif; other site 1254439004873 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1254439004874 tRNA binding surface [nucleotide binding]; other site 1254439004875 anticodon binding site; other site 1254439004876 chorismate mutase; Provisional; Region: PRK09239 1254439004877 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1254439004878 transcription termination factor Rho; Provisional; Region: PRK12608 1254439004879 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1254439004880 RNA binding site [nucleotide binding]; other site 1254439004881 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1254439004882 Walker A motif; other site 1254439004883 ATP binding site [chemical binding]; other site 1254439004884 Walker B motif; other site 1254439004885 hypothetical protein; Provisional; Region: PRK07208 1254439004886 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1254439004887 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1254439004888 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1254439004889 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1254439004890 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1254439004891 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1254439004892 GatB domain; Region: GatB_Yqey; pfam02637 1254439004893 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1254439004894 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1254439004895 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1254439004896 PA14 domain; Region: PA14; cl08459 1254439004897 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 1254439004898 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 1254439004899 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1254439004900 active site 1254439004901 catalytic site [active] 1254439004902 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1254439004903 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1254439004904 RmuC family; Region: RmuC; pfam02646 1254439004905 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1254439004906 putative homodimer interface [polypeptide binding]; other site 1254439004907 putative homotetramer interface [polypeptide binding]; other site 1254439004908 putative allosteric switch controlling residues; other site 1254439004909 putative metal binding site [ion binding]; other site 1254439004910 putative homodimer-homodimer interface [polypeptide binding]; other site 1254439004911 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1254439004912 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1254439004913 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1254439004914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439004915 active site 1254439004916 motif I; other site 1254439004917 motif II; other site 1254439004918 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1254439004919 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1254439004920 Clp amino terminal domain; Region: Clp_N; pfam02861 1254439004921 Clp amino terminal domain; Region: Clp_N; pfam02861 1254439004922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439004923 Walker A motif; other site 1254439004924 ATP binding site [chemical binding]; other site 1254439004925 Walker B motif; other site 1254439004926 arginine finger; other site 1254439004927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1254439004928 Walker A motif; other site 1254439004929 ATP binding site [chemical binding]; other site 1254439004930 Walker B motif; other site 1254439004931 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1254439004932 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1254439004933 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1254439004934 active site 1254439004935 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1254439004936 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1254439004937 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1254439004938 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1254439004939 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1254439004940 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1254439004941 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 1254439004942 putative active site [active] 1254439004943 putative catalytic site [active] 1254439004944 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1254439004945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439004946 dimer interface [polypeptide binding]; other site 1254439004947 conserved gate region; other site 1254439004948 putative PBP binding loops; other site 1254439004949 ABC-ATPase subunit interface; other site 1254439004950 potential frameshift: common BLAST hit: gi|283457003|ref|YP_003361567.1| LacI family transcriptional regulator 1254439004951 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439004952 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1254439004953 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1254439004954 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1254439004955 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1254439004956 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1254439004957 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1254439004958 ligand binding site [chemical binding]; other site 1254439004959 flexible hinge region; other site 1254439004960 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1254439004961 putative switch regulator; other site 1254439004962 non-specific DNA interactions [nucleotide binding]; other site 1254439004963 DNA binding site [nucleotide binding] 1254439004964 sequence specific DNA binding site [nucleotide binding]; other site 1254439004965 putative cAMP binding site [chemical binding]; other site 1254439004966 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 1254439004967 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1254439004968 metal-binding site [ion binding] 1254439004969 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1254439004970 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1254439004971 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1254439004972 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1254439004973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439004974 dimer interface [polypeptide binding]; other site 1254439004975 conserved gate region; other site 1254439004976 putative PBP binding loops; other site 1254439004977 ABC-ATPase subunit interface; other site 1254439004978 sulfate transport protein; Provisional; Region: cysT; CHL00187 1254439004979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439004980 dimer interface [polypeptide binding]; other site 1254439004981 conserved gate region; other site 1254439004982 putative PBP binding loops; other site 1254439004983 ABC-ATPase subunit interface; other site 1254439004984 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1254439004985 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1254439004986 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1254439004987 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1254439004988 Walker A/P-loop; other site 1254439004989 ATP binding site [chemical binding]; other site 1254439004990 Q-loop/lid; other site 1254439004991 ABC transporter signature motif; other site 1254439004992 Walker B; other site 1254439004993 D-loop; other site 1254439004994 H-loop/switch region; other site 1254439004995 TOBE domain; Region: TOBE_2; pfam08402 1254439004996 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1254439004997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1254439004998 DNA-binding site [nucleotide binding]; DNA binding site 1254439004999 Cache domain; Region: Cache_1; pfam02743 1254439005000 Rhomboid family; Region: Rhomboid; pfam01694 1254439005001 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1254439005002 active site 1254439005003 catalytic site [active] 1254439005004 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1254439005005 Cna protein B-type domain; Region: Cna_B; pfam05738 1254439005006 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1254439005007 metal ion-dependent adhesion site (MIDAS); other site 1254439005008 Acylphosphatase; Region: Acylphosphatase; pfam00708 1254439005009 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1254439005010 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1254439005011 catalytic residue [active] 1254439005012 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1254439005013 active site 1254439005014 HIGH motif; other site 1254439005015 nucleotide binding site [chemical binding]; other site 1254439005016 active site 1254439005017 KMSKS motif; other site 1254439005018 potential protein location (hypothetical protein D805_07520 [Bifidobacterium thermophilum RBL67]) that overlaps RNA (tRNA-K) 1254439005019 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1254439005020 amphipathic channel; other site 1254439005021 Asn-Pro-Ala signature motifs; other site 1254439005022 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1254439005023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1254439005024 UDP-galactopyranose mutase; Region: GLF; pfam03275 1254439005025 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1254439005026 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1254439005027 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1254439005028 Transglycosylase; Region: Transgly; pfam00912 1254439005029 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1254439005030 2-isopropylmalate synthase; Validated; Region: PRK03739 1254439005031 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1254439005032 active site 1254439005033 catalytic residues [active] 1254439005034 metal binding site [ion binding]; metal-binding site 1254439005035 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1254439005036 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1254439005037 metal binding site [ion binding]; metal-binding site 1254439005038 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1254439005039 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 1254439005040 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1254439005041 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1254439005042 putative dimer interface [polypeptide binding]; other site 1254439005043 Cation efflux family; Region: Cation_efflux; pfam01545 1254439005044 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1254439005045 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1254439005046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1254439005047 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1254439005048 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1254439005049 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 1254439005050 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1254439005051 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1254439005052 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1254439005053 catalytic triad [active] 1254439005054 RDD family; Region: RDD; pfam06271 1254439005055 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1254439005056 FtsX-like permease family; Region: FtsX; pfam02687 1254439005057 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1254439005058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439005059 Q-loop/lid; other site 1254439005060 ABC transporter signature motif; other site 1254439005061 Walker B; other site 1254439005062 D-loop; other site 1254439005063 H-loop/switch region; other site 1254439005064 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1254439005065 Zn2+ binding site [ion binding]; other site 1254439005066 Mg2+ binding site [ion binding]; other site 1254439005067 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1254439005068 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1254439005069 putative active site [active] 1254439005070 putative dimer interface [polypeptide binding]; other site 1254439005071 K+ potassium transporter; Region: K_trans; pfam02705 1254439005072 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1254439005073 active site 1254439005074 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1254439005075 trimer interface [polypeptide binding]; other site 1254439005076 active site 1254439005077 Predicted transcriptional regulators [Transcription]; Region: COG1733 1254439005078 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1254439005079 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1254439005080 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1254439005081 NAD binding site [chemical binding]; other site 1254439005082 substrate binding site [chemical binding]; other site 1254439005083 putative active site [active] 1254439005084 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 1254439005085 putative ADP-ribose binding site [chemical binding]; other site 1254439005086 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1254439005087 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 1254439005088 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1254439005089 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1254439005090 active site 1254439005091 HIGH motif; other site 1254439005092 KMSKS motif; other site 1254439005093 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1254439005094 tRNA binding surface [nucleotide binding]; other site 1254439005095 anticodon binding site; other site 1254439005096 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1254439005097 Predicted methyltransferases [General function prediction only]; Region: COG0313 1254439005098 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1254439005099 putative SAM binding site [chemical binding]; other site 1254439005100 putative homodimer interface [polypeptide binding]; other site 1254439005101 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1254439005102 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1254439005103 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1254439005104 active site 1254439005105 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1254439005106 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1254439005107 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1254439005108 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1254439005109 metal binding site [ion binding]; metal-binding site 1254439005110 active site 1254439005111 I-site; other site 1254439005112 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1254439005113 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1254439005114 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1254439005115 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 1254439005116 GIY-YIG motif/motif A; other site 1254439005117 putative active site [active] 1254439005118 putative metal binding site [ion binding]; other site 1254439005119 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1254439005120 MgtC family; Region: MgtC; pfam02308 1254439005121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1254439005122 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1254439005123 motif I; other site 1254439005124 active site 1254439005125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1254439005126 motif II; other site 1254439005127 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1254439005128 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1254439005129 DNA binding residues [nucleotide binding] 1254439005130 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 1254439005131 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1254439005132 HSP70 interaction site [polypeptide binding]; other site 1254439005133 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1254439005134 substrate binding site [polypeptide binding]; other site 1254439005135 dimer interface [polypeptide binding]; other site 1254439005136 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 1254439005137 GrpE; Region: GrpE; pfam01025 1254439005138 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1254439005139 dimer interface [polypeptide binding]; other site 1254439005140 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1254439005141 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1254439005142 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1254439005143 nucleotide binding site [chemical binding]; other site 1254439005144 NEF interaction site [polypeptide binding]; other site 1254439005145 SBD interface [polypeptide binding]; other site 1254439005146 alkaline phosphatase; Provisional; Region: PRK10518 1254439005147 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1254439005148 active site 1254439005149 dimer interface [polypeptide binding]; other site 1254439005150 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439005151 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1254439005152 DNA binding site [nucleotide binding] 1254439005153 domain linker motif; other site 1254439005154 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1254439005155 ligand binding site [chemical binding]; other site 1254439005156 dimerization interface [polypeptide binding]; other site 1254439005157 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1254439005158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439005159 motif II; other site 1254439005160 trehalose synthase; Region: treS_nterm; TIGR02456 1254439005161 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 1254439005162 active site 1254439005163 catalytic site [active] 1254439005164 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1254439005165 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1254439005166 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1254439005167 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1254439005168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439005169 dimer interface [polypeptide binding]; other site 1254439005170 conserved gate region; other site 1254439005171 putative PBP binding loops; other site 1254439005172 ABC-ATPase subunit interface; other site 1254439005173 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1254439005174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439005175 dimer interface [polypeptide binding]; other site 1254439005176 conserved gate region; other site 1254439005177 putative PBP binding loops; other site 1254439005178 ABC-ATPase subunit interface; other site 1254439005179 pullulanase, type I; Region: pulA_typeI; TIGR02104 1254439005180 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1254439005181 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1254439005182 Ca binding site [ion binding]; other site 1254439005183 active site 1254439005184 catalytic site [active] 1254439005185 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1254439005186 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1254439005187 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1254439005188 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1254439005189 Protein of unknown function, DUF624; Region: DUF624; cl02369 1254439005190 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1254439005191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439005192 dimer interface [polypeptide binding]; other site 1254439005193 conserved gate region; other site 1254439005194 putative PBP binding loops; other site 1254439005195 ABC-ATPase subunit interface; other site 1254439005196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439005197 dimer interface [polypeptide binding]; other site 1254439005198 conserved gate region; other site 1254439005199 putative PBP binding loops; other site 1254439005200 ABC-ATPase subunit interface; other site 1254439005201 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439005202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1254439005203 DNA binding site [nucleotide binding] 1254439005204 domain linker motif; other site 1254439005205 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1254439005206 ligand binding site [chemical binding]; other site 1254439005207 dimerization interface [polypeptide binding]; other site 1254439005208 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1254439005209 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1254439005210 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1254439005211 catalytic core [active] 1254439005212 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1254439005213 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1254439005214 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1254439005215 dimer interface [polypeptide binding]; other site 1254439005216 FMN binding site [chemical binding]; other site 1254439005217 NADPH bind site [chemical binding]; other site 1254439005218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439005219 putative substrate translocation pore; other site 1254439005220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1254439005221 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1254439005222 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1254439005223 active site 1254439005224 catalytic tetrad [active] 1254439005225 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1254439005226 SWIM zinc finger; Region: SWIM; pfam04434 1254439005227 UGMP family protein; Validated; Region: PRK09604 1254439005228 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1254439005229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1254439005230 Coenzyme A binding pocket [chemical binding]; other site 1254439005231 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1254439005232 Glycoprotease family; Region: Peptidase_M22; pfam00814 1254439005233 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1254439005234 hypothetical protein; Reviewed; Region: PRK07914 1254439005235 Competence protein; Region: Competence; pfam03772 1254439005236 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1254439005237 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1254439005238 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1254439005239 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1254439005240 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1254439005241 active site 1254439005242 HIGH motif; other site 1254439005243 nucleotide binding site [chemical binding]; other site 1254439005244 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1254439005245 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1254439005246 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1254439005247 active site 1254439005248 KMSKS motif; other site 1254439005249 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1254439005250 tRNA binding surface [nucleotide binding]; other site 1254439005251 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1254439005252 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1254439005253 substrate binding pocket [chemical binding]; other site 1254439005254 membrane-bound complex binding site; other site 1254439005255 hinge residues; other site 1254439005256 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1254439005257 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1254439005258 Cl binding site [ion binding]; other site 1254439005259 oligomer interface [polypeptide binding]; other site 1254439005260 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1254439005261 Cadmium resistance transporter; Region: Cad; pfam03596 1254439005262 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1254439005263 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1254439005264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439005265 motif II; other site 1254439005266 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1254439005267 EamA-like transporter family; Region: EamA; pfam00892 1254439005268 EamA-like transporter family; Region: EamA; pfam00892 1254439005269 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1254439005270 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1254439005271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1254439005272 FeS/SAM binding site; other site 1254439005273 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 1254439005274 putative ligand binding pocket/active site [active] 1254439005275 putative metal binding site [ion binding]; other site 1254439005276 AMMECR1; Region: AMMECR1; pfam01871 1254439005277 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 1254439005278 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1254439005279 catalytic core [active] 1254439005280 Oligomerisation domain; Region: Oligomerisation; pfam02410 1254439005281 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1254439005282 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1254439005283 Substrate binding site; other site 1254439005284 Mg++ binding site; other site 1254439005285 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1254439005286 active site 1254439005287 substrate binding site [chemical binding]; other site 1254439005288 CoA binding site [chemical binding]; other site 1254439005289 MULE transposase domain; Region: MULE; pfam10551 1254439005290 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1254439005291 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1254439005292 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1254439005293 active site 1254439005294 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1254439005295 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1254439005296 active site 1254439005297 (T/H)XGH motif; other site 1254439005298 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1254439005299 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1254439005300 putative catalytic cysteine [active] 1254439005301 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1254439005302 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1254439005303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439005304 catalytic residue [active] 1254439005305 Predicted transcriptional regulators [Transcription]; Region: COG1725 1254439005306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1254439005307 DNA-binding site [nucleotide binding]; DNA binding site 1254439005308 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1254439005309 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1254439005310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439005311 active site 1254439005312 motif I; other site 1254439005313 motif II; other site 1254439005314 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1254439005315 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1254439005316 Walker A/P-loop; other site 1254439005317 ATP binding site [chemical binding]; other site 1254439005318 Q-loop/lid; other site 1254439005319 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1254439005320 ABC transporter signature motif; other site 1254439005321 Walker B; other site 1254439005322 D-loop; other site 1254439005323 H-loop/switch region; other site 1254439005324 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1254439005325 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1254439005326 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1254439005327 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1254439005328 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1254439005329 TrkA-N domain; Region: TrkA_N; pfam02254 1254439005330 TrkA-C domain; Region: TrkA_C; pfam02080 1254439005331 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1254439005332 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1254439005333 RNA binding surface [nucleotide binding]; other site 1254439005334 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1254439005335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1254439005336 S-adenosylmethionine binding site [chemical binding]; other site 1254439005337 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1254439005338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439005339 active site 1254439005340 motif I; other site 1254439005341 motif II; other site 1254439005342 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439005343 motif II; other site 1254439005344 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1254439005345 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1254439005346 active site 1254439005347 HIGH motif; other site 1254439005348 dimer interface [polypeptide binding]; other site 1254439005349 KMSKS motif; other site 1254439005350 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1254439005351 RNA binding surface [nucleotide binding]; other site 1254439005352 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1254439005353 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1254439005354 Zn2+ binding site [ion binding]; other site 1254439005355 Mg2+ binding site [ion binding]; other site 1254439005356 argininosuccinate lyase; Provisional; Region: PRK00855 1254439005357 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1254439005358 active sites [active] 1254439005359 tetramer interface [polypeptide binding]; other site 1254439005360 argininosuccinate synthase; Provisional; Region: PRK13820 1254439005361 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1254439005362 ANP binding site [chemical binding]; other site 1254439005363 Substrate Binding Site II [chemical binding]; other site 1254439005364 Substrate Binding Site I [chemical binding]; other site 1254439005365 arginine repressor; Provisional; Region: PRK03341 1254439005366 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1254439005367 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1254439005368 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1254439005369 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1254439005370 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1254439005371 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1254439005372 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1254439005373 inhibitor-cofactor binding pocket; inhibition site 1254439005374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439005375 catalytic residue [active] 1254439005376 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1254439005377 feedback inhibition sensing region; other site 1254439005378 homohexameric interface [polypeptide binding]; other site 1254439005379 nucleotide binding site [chemical binding]; other site 1254439005380 N-acetyl-L-glutamate binding site [chemical binding]; other site 1254439005381 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1254439005382 heterotetramer interface [polypeptide binding]; other site 1254439005383 active site pocket [active] 1254439005384 cleavage site 1254439005385 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1254439005386 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1254439005387 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1254439005388 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1254439005389 putative tRNA-binding site [nucleotide binding]; other site 1254439005390 B3/4 domain; Region: B3_4; pfam03483 1254439005391 tRNA synthetase B5 domain; Region: B5; pfam03484 1254439005392 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1254439005393 dimer interface [polypeptide binding]; other site 1254439005394 motif 1; other site 1254439005395 motif 3; other site 1254439005396 motif 2; other site 1254439005397 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1254439005398 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1254439005399 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1254439005400 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1254439005401 dimer interface [polypeptide binding]; other site 1254439005402 motif 1; other site 1254439005403 active site 1254439005404 motif 2; other site 1254439005405 motif 3; other site 1254439005406 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1254439005407 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1254439005408 hypothetical protein; Provisional; Region: PRK13690 1254439005409 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1254439005410 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1254439005411 Walker A/P-loop; other site 1254439005412 ATP binding site [chemical binding]; other site 1254439005413 Q-loop/lid; other site 1254439005414 ABC transporter signature motif; other site 1254439005415 Walker B; other site 1254439005416 D-loop; other site 1254439005417 H-loop/switch region; other site 1254439005418 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1254439005419 Walker A/P-loop; other site 1254439005420 ATP binding site [chemical binding]; other site 1254439005421 Q-loop/lid; other site 1254439005422 ABC transporter signature motif; other site 1254439005423 Walker B; other site 1254439005424 D-loop; other site 1254439005425 H-loop/switch region; other site 1254439005426 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1254439005427 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1254439005428 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1254439005429 hypothetical protein; Provisional; Region: PRK07907 1254439005430 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1254439005431 active site 1254439005432 metal binding site [ion binding]; metal-binding site 1254439005433 dimer interface [polypeptide binding]; other site 1254439005434 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1254439005435 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1254439005436 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1254439005437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1254439005438 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1254439005439 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1254439005440 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 1254439005441 glutamine synthetase, type I; Region: GlnA; TIGR00653 1254439005442 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1254439005443 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1254439005444 Domain of unknown function DUF59; Region: DUF59; cl00941 1254439005445 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1254439005446 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1254439005447 Walker A motif; other site 1254439005448 Ligase N family; Region: LIGANc; smart00532 1254439005449 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1254439005450 nucleotide binding pocket [chemical binding]; other site 1254439005451 K-X-D-G motif; other site 1254439005452 catalytic site [active] 1254439005453 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1254439005454 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1254439005455 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1254439005456 Dimer interface [polypeptide binding]; other site 1254439005457 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1254439005458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1254439005459 Walker A/P-loop; other site 1254439005460 ATP binding site [chemical binding]; other site 1254439005461 ABC transporter signature motif; other site 1254439005462 Walker B; other site 1254439005463 D-loop; other site 1254439005464 H-loop/switch region; other site 1254439005465 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1254439005466 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1254439005467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439005468 homodimer interface [polypeptide binding]; other site 1254439005469 catalytic residue [active] 1254439005470 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1254439005471 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1254439005472 nucleotide binding site [chemical binding]; other site 1254439005473 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1254439005474 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1254439005475 active site 1254439005476 Predicted membrane protein [Function unknown]; Region: COG3601 1254439005477 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1254439005478 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1254439005479 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1254439005480 Walker A/P-loop; other site 1254439005481 ATP binding site [chemical binding]; other site 1254439005482 Q-loop/lid; other site 1254439005483 ABC transporter signature motif; other site 1254439005484 Walker B; other site 1254439005485 D-loop; other site 1254439005486 H-loop/switch region; other site 1254439005487 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1254439005488 Walker A/P-loop; other site 1254439005489 ATP binding site [chemical binding]; other site 1254439005490 Q-loop/lid; other site 1254439005491 ABC transporter signature motif; other site 1254439005492 Walker B; other site 1254439005493 D-loop; other site 1254439005494 H-loop/switch region; other site 1254439005495 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1254439005496 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1254439005497 NAD-dependent deacetylase; Provisional; Region: PRK00481 1254439005498 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1254439005499 NAD+ binding site [chemical binding]; other site 1254439005500 substrate binding site [chemical binding]; other site 1254439005501 Zn binding site [ion binding]; other site 1254439005502 threonine dehydratase; Provisional; Region: PRK08198 1254439005503 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1254439005504 tetramer interface [polypeptide binding]; other site 1254439005505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1254439005506 catalytic residue [active] 1254439005507 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1254439005508 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1254439005509 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1254439005510 Ca binding site [ion binding]; other site 1254439005511 active site 1254439005512 catalytic site [active] 1254439005513 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1254439005514 probable galactinol--sucrose galactosyltransferase 1; Region: PLN02355 1254439005515 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1254439005516 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1254439005517 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1254439005518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439005519 dimer interface [polypeptide binding]; other site 1254439005520 conserved gate region; other site 1254439005521 putative PBP binding loops; other site 1254439005522 ABC-ATPase subunit interface; other site 1254439005523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1254439005524 dimer interface [polypeptide binding]; other site 1254439005525 conserved gate region; other site 1254439005526 putative PBP binding loops; other site 1254439005527 ABC-ATPase subunit interface; other site 1254439005528 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1254439005529 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1254439005530 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1254439005531 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1254439005532 nucleotide binding site [chemical binding]; other site 1254439005533 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1254439005534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1254439005535 active site 1254439005536 phosphorylation site [posttranslational modification] 1254439005537 intermolecular recognition site; other site 1254439005538 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1254439005539 DNA binding residues [nucleotide binding] 1254439005540 dimerization interface [polypeptide binding]; other site 1254439005541 Histidine kinase; Region: HisKA_3; pfam07730 1254439005542 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1254439005543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1254439005544 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1254439005545 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1254439005546 Walker A/P-loop; other site 1254439005547 ATP binding site [chemical binding]; other site 1254439005548 Q-loop/lid; other site 1254439005549 ABC transporter signature motif; other site 1254439005550 Walker B; other site 1254439005551 D-loop; other site 1254439005552 H-loop/switch region; other site 1254439005553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1254439005554 Histidine kinase; Region: HisKA_3; pfam07730 1254439005555 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1254439005556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1254439005557 active site 1254439005558 phosphorylation site [posttranslational modification] 1254439005559 intermolecular recognition site; other site 1254439005560 dimerization interface [polypeptide binding]; other site 1254439005561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1254439005562 DNA binding residues [nucleotide binding] 1254439005563 dimerization interface [polypeptide binding]; other site 1254439005564 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1254439005565 Melibiase; Region: Melibiase; pfam02065 1254439005566 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1254439005567 nucleoside/Zn binding site; other site 1254439005568 dimer interface [polypeptide binding]; other site 1254439005569 catalytic motif [active] 1254439005570 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1254439005571 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1254439005572 Predicted esterase [General function prediction only]; Region: COG0400 1254439005573 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1254439005574 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1254439005575 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1254439005576 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1254439005577 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1254439005578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1254439005579 motif II; other site 1254439005580 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1254439005581 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1254439005582 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1254439005583 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1254439005584 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1254439005585 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1254439005586 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1254439005587 Walker A/P-loop; other site 1254439005588 ATP binding site [chemical binding]; other site 1254439005589 Q-loop/lid; other site 1254439005590 ABC transporter signature motif; other site 1254439005591 Walker B; other site 1254439005592 D-loop; other site 1254439005593 H-loop/switch region; other site 1254439005594 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1254439005595 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1254439005596 active site 1254439005597 ATP binding site [chemical binding]; other site 1254439005598 substrate binding site [chemical binding]; other site 1254439005599 activation loop (A-loop); other site 1254439005600 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1254439005601 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1254439005602 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1254439005603 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1254439005604 G5 domain; Region: G5; pfam07501 1254439005605 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1254439005606 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1254439005607 catalytic residue [active] 1254439005608 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1254439005609 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1254439005610 S-adenosylmethionine binding site [chemical binding]; other site 1254439005611 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1254439005612 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1254439005613 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1254439005614 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1254439005615 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1254439005616 active site 1254439005617 NTP binding site [chemical binding]; other site 1254439005618 metal binding triad [ion binding]; metal-binding site 1254439005619 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1254439005620 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1254439005621 Zn2+ binding site [ion binding]; other site 1254439005622 Mg2+ binding site [ion binding]; other site 1254439005623 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1254439005624 active site 1254439005625 Ap6A binding site [chemical binding]; other site 1254439005626 nudix motif; other site 1254439005627 metal binding site [ion binding]; metal-binding site 1254439005628 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1254439005629 MviN-like protein; Region: MVIN; pfam03023 1254439005630 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1254439005631 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1254439005632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1254439005633 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1254439005634 ParB-like nuclease domain; Region: ParB; smart00470 1254439005635 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1254439005636 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1254439005637 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1254439005638 Magnesium ion binding site [ion binding]; other site 1254439005639 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1254439005640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1254439005641 S-adenosylmethionine binding site [chemical binding]; other site 1254439005642 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1254439005643 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1254439005644 G-X-X-G motif; other site 1254439005645 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1254439005646 RxxxH motif; other site 1254439005647 PgaD-like protein; Region: PgaD; cl14676 1254439005648 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1254439005649 Haemolytic domain; Region: Haemolytic; cl00506 1254439005650 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399