-- dump date 20140619_003217 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1186051000001 transcription termination factor NusA; Region: NusA; TIGR01953 1186051000002 NusA N-terminal domain; Region: NusA_N; pfam08529 1186051000003 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1186051000004 RNA binding site [nucleotide binding]; other site 1186051000005 homodimer interface [polypeptide binding]; other site 1186051000006 NusA-like KH domain; Region: KH_5; pfam13184 1186051000007 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1186051000008 G-X-X-G motif; other site 1186051000009 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1186051000010 translation initiation factor IF-2; Region: IF-2; TIGR00487 1186051000011 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1186051000012 G1 box; other site 1186051000013 putative GEF interaction site [polypeptide binding]; other site 1186051000014 GTP/Mg2+ binding site [chemical binding]; other site 1186051000015 Switch I region; other site 1186051000016 G2 box; other site 1186051000017 G3 box; other site 1186051000018 Switch II region; other site 1186051000019 G4 box; other site 1186051000020 G5 box; other site 1186051000021 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1186051000022 Translation-initiation factor 2; Region: IF-2; pfam11987 1186051000023 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1186051000024 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1186051000025 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1186051000026 dimer interface [polypeptide binding]; other site 1186051000027 anticodon binding site; other site 1186051000028 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1186051000029 motif 1; other site 1186051000030 dimer interface [polypeptide binding]; other site 1186051000031 active site 1186051000032 motif 2; other site 1186051000033 GAD domain; Region: GAD; pfam02938 1186051000034 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1186051000035 active site 1186051000036 motif 3; other site 1186051000037 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1186051000038 dimer interface [polypeptide binding]; other site 1186051000039 substrate binding site [chemical binding]; other site 1186051000040 metal binding sites [ion binding]; metal-binding site 1186051000041 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1186051000042 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1186051000043 E3 interaction surface; other site 1186051000044 lipoyl attachment site [posttranslational modification]; other site 1186051000045 e3 binding domain; Region: E3_binding; pfam02817 1186051000046 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1186051000047 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1186051000048 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1186051000049 putative substrate binding site [chemical binding]; other site 1186051000050 putative ATP binding site [chemical binding]; other site 1186051000051 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1186051000052 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1186051000053 putative active site [active] 1186051000054 catalytic triad [active] 1186051000055 putative dimer interface [polypeptide binding]; other site 1186051000056 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1186051000057 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1186051000058 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1186051000059 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1186051000060 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1186051000061 rod shape-determining protein MreC; Provisional; Region: PRK13922 1186051000062 rod shape-determining protein MreC; Region: MreC; pfam04085 1186051000063 rod shape-determining protein MreB; Provisional; Region: PRK13927 1186051000064 MreB and similar proteins; Region: MreB_like; cd10225 1186051000065 nucleotide binding site [chemical binding]; other site 1186051000066 Mg binding site [ion binding]; other site 1186051000067 putative protofilament interaction site [polypeptide binding]; other site 1186051000068 RodZ interaction site [polypeptide binding]; other site 1186051000069 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1186051000070 catalytic center binding site [active] 1186051000071 ATP binding site [chemical binding]; other site 1186051000072 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1186051000073 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1186051000074 homotrimer interaction site [polypeptide binding]; other site 1186051000075 putative active site [active] 1186051000076 OstA-like protein; Region: OstA_2; pfam13100 1186051000077 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1186051000078 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1186051000079 inhibitor-cofactor binding pocket; inhibition site 1186051000080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1186051000081 catalytic residue [active] 1186051000082 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1186051000083 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1186051000084 dimerization interface 3.5A [polypeptide binding]; other site 1186051000085 active site 1186051000086 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1186051000087 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1186051000088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1186051000089 Walker A/P-loop; other site 1186051000090 ATP binding site [chemical binding]; other site 1186051000091 Q-loop/lid; other site 1186051000092 ABC transporter signature motif; other site 1186051000093 Walker B; other site 1186051000094 D-loop; other site 1186051000095 H-loop/switch region; other site 1186051000096 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1186051000097 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1186051000098 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1186051000099 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1186051000100 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1186051000101 Walker A/P-loop; other site 1186051000102 ATP binding site [chemical binding]; other site 1186051000103 Q-loop/lid; other site 1186051000104 ABC transporter signature motif; other site 1186051000105 Walker B; other site 1186051000106 D-loop; other site 1186051000107 H-loop/switch region; other site 1186051000108 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1186051000109 Thiamine pyrophosphokinase; Region: TPK; cd07995 1186051000110 active site 1186051000111 dimerization interface [polypeptide binding]; other site 1186051000112 thiamine binding site [chemical binding]; other site 1186051000113 malate dehydrogenase; Reviewed; Region: PRK06223 1186051000114 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1186051000115 NAD(P) binding site [chemical binding]; other site 1186051000116 dimer interface [polypeptide binding]; other site 1186051000117 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1186051000118 substrate binding site [chemical binding]; other site 1186051000119 glycine dehydrogenase; Provisional; Region: PRK05367 1186051000120 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1186051000121 tetramer interface [polypeptide binding]; other site 1186051000122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1186051000123 catalytic residue [active] 1186051000124 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1186051000125 tetramer interface [polypeptide binding]; other site 1186051000126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1186051000127 catalytic residue [active] 1186051000128 UGMP family protein; Validated; Region: PRK09604 1186051000129 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1186051000130 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1186051000131 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1186051000132 AsnC family; Region: AsnC_trans_reg; pfam01037 1186051000133 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1186051000134 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1186051000135 Zn2+ binding site [ion binding]; other site 1186051000136 Mg2+ binding site [ion binding]; other site 1186051000137 Clp protease; Region: CLP_protease; pfam00574 1186051000138 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1186051000139 oligomer interface [polypeptide binding]; other site 1186051000140 active site residues [active] 1186051000141 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1186051000142 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 1186051000143 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1186051000144 active site 1186051000145 Substrate binding site; other site 1186051000146 Mg++ binding site; other site 1186051000147 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1186051000148 putative trimer interface [polypeptide binding]; other site 1186051000149 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1186051000150 putative trimer interface [polypeptide binding]; other site 1186051000151 putative CoA binding site [chemical binding]; other site 1186051000152 putative CoA binding site [chemical binding]; other site 1186051000153 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1186051000154 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1186051000155 catalytic residue [active] 1186051000156 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 1186051000157 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1186051000158 hexamer interface [polypeptide binding]; other site 1186051000159 Walker A motif; other site 1186051000160 ATP binding site [chemical binding]; other site 1186051000161 Walker B motif; other site 1186051000162 putative hydrolase; Provisional; Region: PRK02113 1186051000163 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1186051000164 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1186051000165 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1186051000166 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1186051000167 putative acyl-acceptor binding pocket; other site 1186051000168 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1186051000169 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1186051000170 motif 1; other site 1186051000171 active site 1186051000172 motif 2; other site 1186051000173 motif 3; other site 1186051000174 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1186051000175 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1186051000176 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1186051000177 TPP-binding site [chemical binding]; other site 1186051000178 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1186051000179 dimer interface [polypeptide binding]; other site 1186051000180 PYR/PP interface [polypeptide binding]; other site 1186051000181 TPP binding site [chemical binding]; other site 1186051000182 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1186051000183 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1186051000184 E3 interaction surface; other site 1186051000185 lipoyl attachment site [posttranslational modification]; other site 1186051000186 e3 binding domain; Region: E3_binding; pfam02817 1186051000187 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1186051000188 Predicted esterase [General function prediction only]; Region: COG0400 1186051000189 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1186051000190 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1186051000191 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1186051000192 Walker A/P-loop; other site 1186051000193 ATP binding site [chemical binding]; other site 1186051000194 Q-loop/lid; other site 1186051000195 ABC transporter signature motif; other site 1186051000196 Walker B; other site 1186051000197 D-loop; other site 1186051000198 H-loop/switch region; other site 1186051000199 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1186051000200 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1186051000201 CoA-ligase; Region: Ligase_CoA; pfam00549 1186051000202 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970 1186051000203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1186051000204 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1186051000205 Walker A motif; other site 1186051000206 ATP binding site [chemical binding]; other site 1186051000207 Walker B motif; other site 1186051000208 arginine finger; other site 1186051000209 UvrB/uvrC motif; Region: UVR; pfam02151 1186051000210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1186051000211 Walker A motif; other site 1186051000212 ATP binding site [chemical binding]; other site 1186051000213 Walker B motif; other site 1186051000214 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1186051000215 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1186051000216 endonuclease III; Region: ENDO3c; smart00478 1186051000217 minor groove reading motif; other site 1186051000218 helix-hairpin-helix signature motif; other site 1186051000219 substrate binding pocket [chemical binding]; other site 1186051000220 active site 1186051000221 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 1186051000222 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1186051000223 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1186051000224 Domain of unknown function DUF59; Region: DUF59; cl00941 1186051000225 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1186051000226 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1186051000227 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1186051000228 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1186051000229 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1186051000230 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1186051000231 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1186051000232 Cytochrome c; Region: Cytochrom_C; pfam00034 1186051000233 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1186051000234 heme-binding residues [chemical binding]; other site 1186051000235 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1186051000236 molybdopterin cofactor binding site; other site 1186051000237 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 1186051000238 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1186051000239 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1186051000240 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1186051000241 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 1186051000242 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1186051000243 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1186051000244 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1186051000245 TrkA-N domain; Region: TrkA_N; pfam02254 1186051000246 TrkA-C domain; Region: TrkA_C; pfam02080 1186051000247 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1186051000248 Cation transport protein; Region: TrkH; cl17365 1186051000249 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1186051000250 Glycoprotease family; Region: Peptidase_M22; pfam00814 1186051000251 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1186051000252 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1186051000253 Ligand Binding Site [chemical binding]; other site 1186051000254 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1186051000255 GTP cyclohydrolase I; Provisional; Region: PLN03044 1186051000256 active site 1186051000257 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1186051000258 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051000259 active site 1186051000260 HIGH motif; other site 1186051000261 nucleotide binding site [chemical binding]; other site 1186051000262 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1186051000263 KMSKS motif; other site 1186051000264 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 1186051000265 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1186051000266 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1186051000267 homodimer interface [polypeptide binding]; other site 1186051000268 substrate-cofactor binding pocket; other site 1186051000269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1186051000270 catalytic residue [active] 1186051000271 ATP synthase A chain; Region: ATP-synt_A; cl00413 1186051000272 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1186051000273 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1186051000274 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1186051000275 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1186051000276 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1186051000277 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1186051000278 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1186051000279 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1186051000280 beta subunit interaction interface [polypeptide binding]; other site 1186051000281 Walker A motif; other site 1186051000282 ATP binding site [chemical binding]; other site 1186051000283 Walker B motif; other site 1186051000284 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1186051000285 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1186051000286 core domain interface [polypeptide binding]; other site 1186051000287 delta subunit interface [polypeptide binding]; other site 1186051000288 epsilon subunit interface [polypeptide binding]; other site 1186051000289 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1186051000290 active site 1186051000291 HIGH motif; other site 1186051000292 dimer interface [polypeptide binding]; other site 1186051000293 KMSKS motif; other site 1186051000294 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1186051000295 dimer interface [polypeptide binding]; other site 1186051000296 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1186051000297 chaperone protein DnaJ; Provisional; Region: PRK14289 1186051000298 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1186051000299 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1186051000300 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1186051000301 dimer interface [polypeptide binding]; other site 1186051000302 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1186051000303 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1186051000304 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1186051000305 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 1186051000306 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1186051000307 PYR/PP interface [polypeptide binding]; other site 1186051000308 dimer interface [polypeptide binding]; other site 1186051000309 TPP binding site [chemical binding]; other site 1186051000310 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1186051000311 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1186051000312 TPP-binding site [chemical binding]; other site 1186051000313 dimer interface [polypeptide binding]; other site 1186051000314 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1186051000315 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 1186051000316 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1186051000317 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1186051000318 tetramer interface [polypeptide binding]; other site 1186051000319 threonine dehydratase; Validated; Region: PRK08639 1186051000320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1186051000321 catalytic residue [active] 1186051000322 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1186051000323 putative Ile/Val binding site [chemical binding]; other site 1186051000324 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1186051000325 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1186051000326 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1186051000327 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1186051000328 Catalytic site [active] 1186051000329 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1186051000330 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1186051000331 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 1186051000332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1186051000333 ATP binding site [chemical binding]; other site 1186051000334 Mg2+ binding site [ion binding]; other site 1186051000335 G-X-G motif; other site 1186051000336 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1186051000337 ATP binding site [chemical binding]; other site 1186051000338 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1186051000339 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1186051000340 homopentamer interface [polypeptide binding]; other site 1186051000341 active site 1186051000342 gliding motility-associated protein GldE; Region: GldE; TIGR03520 1186051000343 Domain of unknown function DUF21; Region: DUF21; pfam01595 1186051000344 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1186051000345 Transporter associated domain; Region: CorC_HlyC; smart01091 1186051000346 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1186051000347 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1186051000348 minor groove reading motif; other site 1186051000349 helix-hairpin-helix signature motif; other site 1186051000350 substrate binding pocket [chemical binding]; other site 1186051000351 active site 1186051000352 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1186051000353 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1186051000354 DNA binding and oxoG recognition site [nucleotide binding] 1186051000355 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1186051000356 IHF dimer interface [polypeptide binding]; other site 1186051000357 IHF - DNA interface [nucleotide binding]; other site 1186051000358 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1186051000359 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1186051000360 homodimer interface [polypeptide binding]; other site 1186051000361 oligonucleotide binding site [chemical binding]; other site 1186051000362 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1186051000363 Citrate synthase; Region: Citrate_synt; pfam00285 1186051000364 oxalacetate binding site [chemical binding]; other site 1186051000365 citrylCoA binding site [chemical binding]; other site 1186051000366 coenzyme A binding site [chemical binding]; other site 1186051000367 catalytic triad [active] 1186051000368 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1186051000369 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1186051000370 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1186051000371 active site 1186051000372 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1186051000373 Class II fumarases; Region: Fumarase_classII; cd01362 1186051000374 active site 1186051000375 tetramer interface [polypeptide binding]; other site 1186051000376 Septum formation initiator; Region: DivIC; cl17659 1186051000377 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1186051000378 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1186051000379 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1186051000380 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1186051000381 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1186051000382 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1186051000383 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1186051000384 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1186051000385 active site 1186051000386 catalytic site [active] 1186051000387 substrate binding site [chemical binding]; other site 1186051000388 heat shock protein 90; Provisional; Region: PRK05218 1186051000389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1186051000390 ATP binding site [chemical binding]; other site 1186051000391 Mg2+ binding site [ion binding]; other site 1186051000392 G-X-G motif; other site 1186051000393 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1186051000394 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1186051000395 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1186051000396 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 1186051000397 ribosomal protein L33; Region: rpl33; CHL00104 1186051000398 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1186051000399 Transcriptional regulator; Region: Transcrip_reg; pfam01709 1186051000400 RmuC family; Region: RmuC; pfam02646 1186051000401 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1186051000402 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1186051000403 transcription termination factor Rho; Provisional; Region: PRK12608 1186051000404 RNA binding site [nucleotide binding]; other site 1186051000405 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1186051000406 multimer interface [polypeptide binding]; other site 1186051000407 Walker A motif; other site 1186051000408 ATP binding site [chemical binding]; other site 1186051000409 Walker B motif; other site 1186051000410 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1186051000411 PCRF domain; Region: PCRF; pfam03462 1186051000412 RF-1 domain; Region: RF-1; pfam00472 1186051000413 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1186051000414 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1186051000415 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1186051000416 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1186051000417 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1186051000418 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1186051000419 carboxyltransferase (CT) interaction site; other site 1186051000420 biotinylation site [posttranslational modification]; other site 1186051000421 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1186051000422 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1186051000423 dimer interface [polypeptide binding]; other site 1186051000424 motif 1; other site 1186051000425 active site 1186051000426 motif 2; other site 1186051000427 motif 3; other site 1186051000428 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1186051000429 anticodon binding site; other site 1186051000430 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1186051000431 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 1186051000432 active site 1186051000433 FMN binding site [chemical binding]; other site 1186051000434 substrate binding site [chemical binding]; other site 1186051000435 catalytic residues [active] 1186051000436 homodimer interface [polypeptide binding]; other site 1186051000437 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1186051000438 active site 1186051000439 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1186051000440 active site 1186051000441 dimer interface [polypeptide binding]; other site 1186051000442 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1186051000443 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1186051000444 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1186051000445 AMP binding site [chemical binding]; other site 1186051000446 metal binding site [ion binding]; metal-binding site 1186051000447 active site 1186051000448 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1186051000449 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1186051000450 putative acyl-acceptor binding pocket; other site 1186051000451 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1186051000452 RNA/DNA hybrid binding site [nucleotide binding]; other site 1186051000453 active site 1186051000454 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1186051000455 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1186051000456 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1186051000457 active site 1186051000458 Zn binding site [ion binding]; other site 1186051000459 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1186051000460 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1186051000461 subunit interactions [polypeptide binding]; other site 1186051000462 active site 1186051000463 flap region; other site 1186051000464 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 1186051000465 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1186051000466 alpha-gamma subunit interface [polypeptide binding]; other site 1186051000467 beta-gamma subunit interface [polypeptide binding]; other site 1186051000468 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1186051000469 gamma-beta subunit interface [polypeptide binding]; other site 1186051000470 alpha-beta subunit interface [polypeptide binding]; other site 1186051000471 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1186051000472 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 1186051000473 putative catalytic residues [active] 1186051000474 nucleotide binding site [chemical binding]; other site 1186051000475 aspartate binding site [chemical binding]; other site 1186051000476 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1186051000477 dimer interface [polypeptide binding]; other site 1186051000478 putative threonine allosteric regulatory site; other site 1186051000479 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1186051000480 putative threonine allosteric regulatory site; other site 1186051000481 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1186051000482 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1186051000483 homoserine kinase; Provisional; Region: PRK01212 1186051000484 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1186051000485 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1186051000486 threonine synthase; Validated; Region: PRK09225 1186051000487 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1186051000488 catalytic residue [active] 1186051000489 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1186051000490 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1186051000491 dimerization interface [polypeptide binding]; other site 1186051000492 active site 1186051000493 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1186051000494 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1186051000495 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1186051000496 active site 1186051000497 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1186051000498 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1186051000499 5S rRNA interface [nucleotide binding]; other site 1186051000500 CTC domain interface [polypeptide binding]; other site 1186051000501 L16 interface [polypeptide binding]; other site 1186051000502 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1186051000503 nucleoside/Zn binding site; other site 1186051000504 dimer interface [polypeptide binding]; other site 1186051000505 catalytic motif [active] 1186051000506 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1186051000507 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1186051000508 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1186051000509 active site 1186051000510 dimer interface [polypeptide binding]; other site 1186051000511 metal binding site [ion binding]; metal-binding site 1186051000512 DNA gyrase subunit A; Validated; Region: PRK05560 1186051000513 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1186051000514 CAP-like domain; other site 1186051000515 active site 1186051000516 primary dimer interface [polypeptide binding]; other site 1186051000517 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1186051000518 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1186051000519 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1186051000520 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1186051000521 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1186051000522 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1186051000523 C-terminal peptidase (prc); Region: prc; TIGR00225 1186051000524 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1186051000525 protein binding site [polypeptide binding]; other site 1186051000526 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1186051000527 Catalytic dyad [active] 1186051000528 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1186051000529 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1186051000530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1186051000531 Walker A motif; other site 1186051000532 ATP binding site [chemical binding]; other site 1186051000533 Walker B motif; other site 1186051000534 arginine finger; other site 1186051000535 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1186051000536 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1186051000537 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1186051000538 GDP-binding site [chemical binding]; other site 1186051000539 ACT binding site; other site 1186051000540 IMP binding site; other site 1186051000541 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 1186051000542 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1186051000543 tetramer interface [polypeptide binding]; other site 1186051000544 active site 1186051000545 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1186051000546 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1186051000547 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1186051000548 dimerization interface [polypeptide binding]; other site 1186051000549 ATP binding site [chemical binding]; other site 1186051000550 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1186051000551 dimerization interface [polypeptide binding]; other site 1186051000552 ATP binding site [chemical binding]; other site 1186051000553 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1186051000554 conserved cys residue [active] 1186051000555 AIR carboxylase; Region: AIRC; pfam00731 1186051000556 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1186051000557 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1186051000558 ATP binding site [chemical binding]; other site 1186051000559 active site 1186051000560 substrate binding site [chemical binding]; other site 1186051000561 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 1186051000562 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1186051000563 active site 1186051000564 tetramer interface [polypeptide binding]; other site 1186051000565 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1186051000566 active site 1186051000567 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1186051000568 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1186051000569 dimerization interface [polypeptide binding]; other site 1186051000570 putative ATP binding site [chemical binding]; other site 1186051000571 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1186051000572 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1186051000573 active site 1186051000574 substrate binding site [chemical binding]; other site 1186051000575 cosubstrate binding site; other site 1186051000576 catalytic site [active] 1186051000577 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1186051000578 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1186051000579 purine monophosphate binding site [chemical binding]; other site 1186051000580 dimer interface [polypeptide binding]; other site 1186051000581 putative catalytic residues [active] 1186051000582 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1186051000583 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1186051000584 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1186051000585 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1186051000586 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1186051000587 GMP synthase; Reviewed; Region: guaA; PRK00074 1186051000588 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1186051000589 AMP/PPi binding site [chemical binding]; other site 1186051000590 candidate oxyanion hole; other site 1186051000591 catalytic triad [active] 1186051000592 potential glutamine specificity residues [chemical binding]; other site 1186051000593 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1186051000594 ATP Binding subdomain [chemical binding]; other site 1186051000595 Ligand Binding sites [chemical binding]; other site 1186051000596 Dimerization subdomain; other site 1186051000597 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1186051000598 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1186051000599 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1186051000600 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1186051000601 active site 1186051000602 intersubunit interface [polypeptide binding]; other site 1186051000603 zinc binding site [ion binding]; other site 1186051000604 Na+ binding site [ion binding]; other site 1186051000605 putative recombination protein RecB; Provisional; Region: PRK13909 1186051000606 Family description; Region: UvrD_C_2; pfam13538 1186051000607 lipoyl synthase; Provisional; Region: PRK05481 1186051000608 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1186051000609 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1186051000610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1186051000611 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1186051000612 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1186051000613 Putative zinc ribbon domain; Region: DUF164; pfam02591 1186051000614 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1186051000615 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1186051000616 putative catalytic residue [active] 1186051000617 DHH family; Region: DHH; pfam01368 1186051000618 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1186051000619 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1186051000620 active site 1186051000621 NTP binding site [chemical binding]; other site 1186051000622 metal binding triad [ion binding]; metal-binding site 1186051000623 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1186051000624 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1186051000625 Zn2+ binding site [ion binding]; other site 1186051000626 Mg2+ binding site [ion binding]; other site 1186051000627 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1186051000628 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1186051000629 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1186051000630 trimer interface [polypeptide binding]; other site 1186051000631 active site 1186051000632 substrate binding site [chemical binding]; other site 1186051000633 CoA binding site [chemical binding]; other site 1186051000634 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1186051000635 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1186051000636 active site 1186051000637 catalytic residues [active] 1186051000638 metal binding site [ion binding]; metal-binding site 1186051000639 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1186051000640 23S rRNA binding site [nucleotide binding]; other site 1186051000641 L21 binding site [polypeptide binding]; other site 1186051000642 L13 binding site [polypeptide binding]; other site 1186051000643 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1186051000644 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1186051000645 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1186051000646 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1186051000647 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1186051000648 active site 1186051000649 dimer interface [polypeptide binding]; other site 1186051000650 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1186051000651 motif 1; other site 1186051000652 motif 2; other site 1186051000653 motif 3; other site 1186051000654 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1186051000655 anticodon binding site; other site 1186051000656 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1186051000657 amphipathic channel; other site 1186051000658 Asn-Pro-Ala signature motifs; other site 1186051000659 glycerol kinase; Provisional; Region: glpK; PRK00047 1186051000660 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1186051000661 N- and C-terminal domain interface [polypeptide binding]; other site 1186051000662 active site 1186051000663 MgATP binding site [chemical binding]; other site 1186051000664 catalytic site [active] 1186051000665 metal binding site [ion binding]; metal-binding site 1186051000666 glycerol binding site [chemical binding]; other site 1186051000667 homotetramer interface [polypeptide binding]; other site 1186051000668 homodimer interface [polypeptide binding]; other site 1186051000669 FBP binding site [chemical binding]; other site 1186051000670 protein IIAGlc interface [polypeptide binding]; other site 1186051000671 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1186051000672 signal recognition particle protein; Provisional; Region: PRK10867 1186051000673 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1186051000674 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1186051000675 P loop; other site 1186051000676 GTP binding site [chemical binding]; other site 1186051000677 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1186051000678 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 1186051000679 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051000680 active site 1186051000681 HIGH motif; other site 1186051000682 nucleotide binding site [chemical binding]; other site 1186051000683 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1186051000684 KMSK motif region; other site 1186051000685 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1186051000686 tRNA binding surface [nucleotide binding]; other site 1186051000687 anticodon binding site; other site 1186051000688 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1186051000689 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1186051000690 homodimer interface [polypeptide binding]; other site 1186051000691 substrate-cofactor binding pocket; other site 1186051000692 catalytic residue [active] 1186051000693 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1186051000694 tetramer interface [polypeptide binding]; other site 1186051000695 TPP-binding site [chemical binding]; other site 1186051000696 heterodimer interface [polypeptide binding]; other site 1186051000697 phosphorylation loop region [posttranslational modification] 1186051000698 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1186051000699 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1186051000700 PYR/PP interface [polypeptide binding]; other site 1186051000701 dimer interface [polypeptide binding]; other site 1186051000702 TPP binding site [chemical binding]; other site 1186051000703 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1186051000704 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1186051000705 active site 1186051000706 multimer interface [polypeptide binding]; other site 1186051000707 LemA family; Region: LemA; cl00742 1186051000708 Repair protein; Region: Repair_PSII; pfam04536 1186051000709 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1186051000710 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051000711 active site 1186051000712 HIGH motif; other site 1186051000713 nucleotide binding site [chemical binding]; other site 1186051000714 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1186051000715 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051000716 active site 1186051000717 KMSKS motif; other site 1186051000718 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1186051000719 tRNA binding surface [nucleotide binding]; other site 1186051000720 anticodon binding site; other site 1186051000721 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1186051000722 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1186051000723 folate binding site [chemical binding]; other site 1186051000724 NADP+ binding site [chemical binding]; other site 1186051000725 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1186051000726 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 1186051000727 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1186051000728 alpha subunit interface [polypeptide binding]; other site 1186051000729 TPP binding site [chemical binding]; other site 1186051000730 heterodimer interface [polypeptide binding]; other site 1186051000731 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1186051000732 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1186051000733 FAD binding site [chemical binding]; other site 1186051000734 seryl-tRNA synthetase; Provisional; Region: PRK05431 1186051000735 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1186051000736 motif 1; other site 1186051000737 dimer interface [polypeptide binding]; other site 1186051000738 active site 1186051000739 motif 2; other site 1186051000740 motif 3; other site 1186051000741 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1186051000742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1186051000743 S-adenosylmethionine binding site [chemical binding]; other site 1186051000744 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1186051000745 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1186051000746 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1186051000747 homodimer interface [polypeptide binding]; other site 1186051000748 NADP binding site [chemical binding]; other site 1186051000749 substrate binding site [chemical binding]; other site 1186051000750 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1186051000751 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1186051000752 FeS/SAM binding site; other site 1186051000753 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1186051000754 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1186051000755 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1186051000756 metal binding site [ion binding]; metal-binding site 1186051000757 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1186051000758 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1186051000759 substrate binding site [chemical binding]; other site 1186051000760 glutamase interaction surface [polypeptide binding]; other site 1186051000761 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1186051000762 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1186051000763 catalytic residues [active] 1186051000764 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 1186051000765 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1186051000766 putative active site [active] 1186051000767 oxyanion strand; other site 1186051000768 catalytic triad [active] 1186051000769 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1186051000770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1186051000771 active site 1186051000772 motif I; other site 1186051000773 motif II; other site 1186051000774 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1186051000775 putative active site pocket [active] 1186051000776 4-fold oligomerization interface [polypeptide binding]; other site 1186051000777 metal binding residues [ion binding]; metal-binding site 1186051000778 3-fold/trimer interface [polypeptide binding]; other site 1186051000779 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 1186051000780 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1186051000781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1186051000782 homodimer interface [polypeptide binding]; other site 1186051000783 catalytic residue [active] 1186051000784 histidinol dehydrogenase; Region: hisD; TIGR00069 1186051000785 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1186051000786 NAD binding site [chemical binding]; other site 1186051000787 dimerization interface [polypeptide binding]; other site 1186051000788 product binding site; other site 1186051000789 substrate binding site [chemical binding]; other site 1186051000790 zinc binding site [ion binding]; other site 1186051000791 catalytic residues [active] 1186051000792 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1186051000793 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1186051000794 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1186051000795 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1186051000796 putative catalytic site [active] 1186051000797 putative metal binding site [ion binding]; other site 1186051000798 putative phosphate binding site [ion binding]; other site 1186051000799 shikimate kinase; Reviewed; Region: aroK; PRK00131 1186051000800 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1186051000801 ADP binding site [chemical binding]; other site 1186051000802 magnesium binding site [ion binding]; other site 1186051000803 putative shikimate binding site; other site 1186051000804 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1186051000805 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1186051000806 Ligand Binding Site [chemical binding]; other site 1186051000807 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1186051000808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1186051000809 catalytic residue [active] 1186051000810 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1186051000811 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1186051000812 catalytic residue [active] 1186051000813 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1186051000814 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1186051000815 substrate binding site [chemical binding]; other site 1186051000816 active site 1186051000817 catalytic residues [active] 1186051000818 heterodimer interface [polypeptide binding]; other site 1186051000819 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1186051000820 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1186051000821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1186051000822 catalytic residue [active] 1186051000823 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1186051000824 active site 1186051000825 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1186051000826 active site 1186051000827 ribulose/triose binding site [chemical binding]; other site 1186051000828 phosphate binding site [ion binding]; other site 1186051000829 substrate (anthranilate) binding pocket [chemical binding]; other site 1186051000830 product (indole) binding pocket [chemical binding]; other site 1186051000831 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1186051000832 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1186051000833 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1186051000834 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1186051000835 glutamine binding [chemical binding]; other site 1186051000836 catalytic triad [active] 1186051000837 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1186051000838 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1186051000839 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1186051000840 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 1186051000841 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1186051000842 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1186051000843 lipoyl attachment site [posttranslational modification]; other site 1186051000844 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1186051000845 Heavy-metal-associated domain; Region: HMA; pfam00403 1186051000846 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1186051000847 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1186051000848 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 1186051000849 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1186051000850 Low-spin heme binding site [chemical binding]; other site 1186051000851 D-pathway; other site 1186051000852 Putative water exit pathway; other site 1186051000853 Binuclear center (active site) [active] 1186051000854 K-pathway; other site 1186051000855 Putative proton exit pathway; other site 1186051000856 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1186051000857 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1186051000858 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1186051000859 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1186051000860 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1186051000861 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1186051000862 putative NAD(P) binding site [chemical binding]; other site 1186051000863 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1186051000864 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1186051000865 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1186051000866 NlpC/P60 family; Region: NLPC_P60; pfam00877 1186051000867 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 1186051000868 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1186051000869 putative active site [active] 1186051000870 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1186051000871 homodimer interface [polypeptide binding]; other site 1186051000872 metal binding site [ion binding]; metal-binding site 1186051000873 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1186051000874 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1186051000875 PYR/PP interface [polypeptide binding]; other site 1186051000876 dimer interface [polypeptide binding]; other site 1186051000877 TPP binding site [chemical binding]; other site 1186051000878 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1186051000879 transketolase; Reviewed; Region: PRK05899 1186051000880 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1186051000881 TPP-binding site [chemical binding]; other site 1186051000882 dimer interface [polypeptide binding]; other site 1186051000883 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1186051000884 SmpB-tmRNA interface; other site 1186051000885 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1186051000886 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1186051000887 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1186051000888 ligand binding site [chemical binding]; other site 1186051000889 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1186051000890 GTP-binding protein YchF; Reviewed; Region: PRK09601 1186051000891 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1186051000892 G1 box; other site 1186051000893 GTP/Mg2+ binding site [chemical binding]; other site 1186051000894 G2 box; other site 1186051000895 Switch I region; other site 1186051000896 G3 box; other site 1186051000897 Switch II region; other site 1186051000898 G4 box; other site 1186051000899 G5 box; other site 1186051000900 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 1186051000901 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1186051000902 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1186051000903 oligomer interface [polypeptide binding]; other site 1186051000904 active site 1186051000905 metal binding site [ion binding]; metal-binding site 1186051000906 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1186051000907 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1186051000908 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1186051000909 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1186051000910 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1186051000911 protein binding site [polypeptide binding]; other site 1186051000912 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1186051000913 protein binding site [polypeptide binding]; other site 1186051000914 Predicted permeases [General function prediction only]; Region: COG0795 1186051000915 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1186051000916 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1186051000917 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1186051000918 MraW methylase family; Region: Methyltransf_5; cl17771 1186051000919 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1186051000920 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1186051000921 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1186051000922 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1186051000923 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1186051000924 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1186051000925 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1186051000926 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1186051000927 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1186051000928 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1186051000929 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1186051000930 Mg++ binding site [ion binding]; other site 1186051000931 putative catalytic motif [active] 1186051000932 putative substrate binding site [chemical binding]; other site 1186051000933 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1186051000934 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1186051000935 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1186051000936 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1186051000937 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1186051000938 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1186051000939 homodimer interface [polypeptide binding]; other site 1186051000940 active site 1186051000941 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1186051000942 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1186051000943 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1186051000944 cell division protein FtsA; Region: ftsA; TIGR01174 1186051000945 Cell division protein FtsA; Region: FtsA; smart00842 1186051000946 Cell division protein FtsA; Region: FtsA; pfam14450 1186051000947 cell division protein FtsZ; Validated; Region: PRK09330 1186051000948 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1186051000949 nucleotide binding site [chemical binding]; other site 1186051000950 SulA interaction site; other site 1186051000951 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1186051000952 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1186051000953 dimer interface [polypeptide binding]; other site 1186051000954 motif 1; other site 1186051000955 active site 1186051000956 motif 2; other site 1186051000957 motif 3; other site 1186051000958 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1186051000959 anticodon binding site; other site 1186051000960 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1186051000961 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1186051000962 Domain of unknown function DUF59; Region: DUF59; cl00941 1186051000963 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1186051000964 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1186051000965 Walker A motif; other site 1186051000966 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1186051000967 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1186051000968 FAD binding domain; Region: FAD_binding_4; pfam01565 1186051000969 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1186051000970 YtxH-like protein; Region: YtxH; cl02079 1186051000971 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1186051000972 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1186051000973 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1186051000974 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1186051000975 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1186051000976 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1186051000977 dimer interface [polypeptide binding]; other site 1186051000978 motif 1; other site 1186051000979 active site 1186051000980 motif 2; other site 1186051000981 motif 3; other site 1186051000982 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1186051000983 Phosphate transporter family; Region: PHO4; pfam01384 1186051000984 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1186051000985 RuvA N terminal domain; Region: RuvA_N; pfam01330 1186051000986 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1186051000987 GTP-binding protein Der; Reviewed; Region: PRK00093 1186051000988 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1186051000989 G1 box; other site 1186051000990 GTP/Mg2+ binding site [chemical binding]; other site 1186051000991 Switch I region; other site 1186051000992 G2 box; other site 1186051000993 Switch II region; other site 1186051000994 G3 box; other site 1186051000995 G4 box; other site 1186051000996 G5 box; other site 1186051000997 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1186051000998 G1 box; other site 1186051000999 GTP/Mg2+ binding site [chemical binding]; other site 1186051001000 Switch I region; other site 1186051001001 G2 box; other site 1186051001002 G3 box; other site 1186051001003 Switch II region; other site 1186051001004 G4 box; other site 1186051001005 G5 box; other site 1186051001006 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1186051001007 Lyase; Region: Lyase_1; pfam00206 1186051001008 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1186051001009 active sites [active] 1186051001010 tetramer interface [polypeptide binding]; other site 1186051001011 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1186051001012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1186051001013 ATP binding site [chemical binding]; other site 1186051001014 Mg2+ binding site [ion binding]; other site 1186051001015 G-X-G motif; other site 1186051001016 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1186051001017 anchoring element; other site 1186051001018 dimer interface [polypeptide binding]; other site 1186051001019 ATP binding site [chemical binding]; other site 1186051001020 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1186051001021 active site 1186051001022 putative metal-binding site [ion binding]; other site 1186051001023 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1186051001024 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1186051001025 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1186051001026 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1186051001027 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1186051001028 diphosphomevalonate decarboxylase; Region: PLN02407 1186051001029 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1186051001030 aspartate aminotransferase; Provisional; Region: PRK05764 1186051001031 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1186051001032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1186051001033 homodimer interface [polypeptide binding]; other site 1186051001034 catalytic residue [active] 1186051001035 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 1186051001036 hypothetical protein; Validated; Region: PRK06886 1186051001037 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1186051001038 active site 1186051001039 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1186051001040 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1186051001041 dimer interface [polypeptide binding]; other site 1186051001042 putative anticodon binding site; other site 1186051001043 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1186051001044 motif 1; other site 1186051001045 active site 1186051001046 motif 2; other site 1186051001047 motif 3; other site 1186051001048 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1186051001049 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1186051001050 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 1186051001051 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1186051001052 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1186051001053 dimer interface [polypeptide binding]; other site 1186051001054 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1186051001055 catalytic triad [active] 1186051001056 peroxidatic and resolving cysteines [active] 1186051001057 DNA primase, catalytic core; Region: dnaG; TIGR01391 1186051001058 CHC2 zinc finger; Region: zf-CHC2; cl17510 1186051001059 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1186051001060 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1186051001061 active site 1186051001062 metal binding site [ion binding]; metal-binding site 1186051001063 interdomain interaction site; other site 1186051001064 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1186051001065 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1186051001066 substrate binding site [chemical binding]; other site 1186051001067 hexamer interface [polypeptide binding]; other site 1186051001068 metal binding site [ion binding]; metal-binding site 1186051001069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1186051001070 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 1186051001071 NAD(P) binding site [chemical binding]; other site 1186051001072 active site 1186051001073 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1186051001074 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1186051001075 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1186051001076 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1186051001077 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1186051001078 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1186051001079 Chorismate mutase type II; Region: CM_2; smart00830 1186051001080 prephenate dehydrogenase; Validated; Region: PRK08507 1186051001081 Prephenate dehydrogenase; Region: PDH; pfam02153 1186051001082 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1186051001083 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1186051001084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1186051001085 homodimer interface [polypeptide binding]; other site 1186051001086 catalytic residue [active] 1186051001087 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1186051001088 Prephenate dehydratase; Region: PDT; pfam00800 1186051001089 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1186051001090 manganese transport protein MntH; Reviewed; Region: PRK00701 1186051001091 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1186051001092 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1186051001093 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1186051001094 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1186051001095 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1186051001096 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 1186051001097 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1186051001098 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1186051001099 HIGH motif; other site 1186051001100 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1186051001101 active site 1186051001102 KMSKS motif; other site 1186051001103 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1186051001104 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1186051001105 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1186051001106 G1 box; other site 1186051001107 GTP/Mg2+ binding site [chemical binding]; other site 1186051001108 Switch I region; other site 1186051001109 G2 box; other site 1186051001110 Switch II region; other site 1186051001111 G3 box; other site 1186051001112 G4 box; other site 1186051001113 G5 box; other site 1186051001114 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1186051001115 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1186051001116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1186051001117 S-adenosylmethionine binding site [chemical binding]; other site 1186051001118 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 1186051001119 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1186051001120 nucleotide binding pocket [chemical binding]; other site 1186051001121 K-X-D-G motif; other site 1186051001122 catalytic site [active] 1186051001123 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1186051001124 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1186051001125 Dimer interface [polypeptide binding]; other site 1186051001126 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1186051001127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1186051001128 Walker A motif; other site 1186051001129 ATP binding site [chemical binding]; other site 1186051001130 Walker B motif; other site 1186051001131 arginine finger; other site 1186051001132 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1186051001133 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1186051001134 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1186051001135 active site 1186051001136 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1186051001137 substrate binding site [chemical binding]; other site 1186051001138 catalytic residues [active] 1186051001139 dimer interface [polypeptide binding]; other site 1186051001140 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1186051001141 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1186051001142 active site 1186051001143 HIGH motif; other site 1186051001144 KMSKS motif; other site 1186051001145 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1186051001146 tRNA binding surface [nucleotide binding]; other site 1186051001147 anticodon binding site; other site 1186051001148 5'-3' exonuclease; Region: 53EXOc; smart00475 1186051001149 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1186051001150 active site 1186051001151 metal binding site 1 [ion binding]; metal-binding site 1186051001152 putative 5' ssDNA interaction site; other site 1186051001153 metal binding site 3; metal-binding site 1186051001154 metal binding site 2 [ion binding]; metal-binding site 1186051001155 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1186051001156 putative DNA binding site [nucleotide binding]; other site 1186051001157 putative metal binding site [ion binding]; other site 1186051001158 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1186051001159 active site 1186051001160 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1186051001161 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1186051001162 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1186051001163 Predicted permeases [General function prediction only]; Region: COG0795 1186051001164 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1186051001165 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1186051001166 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1186051001167 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1186051001168 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1186051001169 catalytic residues [active] 1186051001170 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1186051001171 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 1186051001172 metal binding site [ion binding]; metal-binding site 1186051001173 dimer interface [polypeptide binding]; other site 1186051001174 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1186051001175 nucleotide binding site [chemical binding]; other site 1186051001176 N-acetyl-L-glutamate binding site [chemical binding]; other site 1186051001177 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 1186051001178 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1186051001179 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1186051001180 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 1186051001181 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1186051001182 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1186051001183 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1186051001184 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1186051001185 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1186051001186 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1186051001187 substrate binding site [chemical binding]; other site 1186051001188 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1186051001189 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1186051001190 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1186051001191 catalytic site [active] 1186051001192 subunit interface [polypeptide binding]; other site 1186051001193 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1186051001194 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1186051001195 inhibitor-cofactor binding pocket; inhibition site 1186051001196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1186051001197 catalytic residue [active] 1186051001198 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1186051001199 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1186051001200 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1186051001201 argininosuccinate synthase; Provisional; Region: PRK13820 1186051001202 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1186051001203 Ligand Binding Site [chemical binding]; other site 1186051001204 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1186051001205 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1186051001206 active site 1186051001207 catalytic site [active] 1186051001208 substrate binding site [chemical binding]; other site 1186051001209 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1186051001210 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1186051001211 active site 1186051001212 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1186051001213 generic binding surface I; other site 1186051001214 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1186051001215 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1186051001216 RNA binding site [nucleotide binding]; other site 1186051001217 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1186051001218 RNA binding site [nucleotide binding]; other site 1186051001219 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1186051001220 RNA binding site [nucleotide binding]; other site 1186051001221 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1186051001222 RNA binding site [nucleotide binding]; other site 1186051001223 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1186051001224 RNA binding site [nucleotide binding]; other site 1186051001225 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1186051001226 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 1186051001227 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1186051001228 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1186051001229 active site 1186051001230 dimer interface [polypeptide binding]; other site 1186051001231 catalytic residues [active] 1186051001232 effector binding site; other site 1186051001233 R2 peptide binding site; other site 1186051001234 potential protein location (Cell wall-associated hydrolase [Blattabacterium sp. (Blaberus giganteus)]) that overlaps RNA (23S ribosomal RNA) 1186051001235 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1186051001236 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1186051001237 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1186051001238 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1186051001239 substrate binding pocket [chemical binding]; other site 1186051001240 chain length determination region; other site 1186051001241 substrate-Mg2+ binding site; other site 1186051001242 catalytic residues [active] 1186051001243 aspartate-rich region 1; other site 1186051001244 active site lid residues [active] 1186051001245 aspartate-rich region 2; other site 1186051001246 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 1186051001247 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1186051001248 active site 1186051001249 metal binding site [ion binding]; metal-binding site 1186051001250 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1186051001251 domain I; other site 1186051001252 DNA binding groove [nucleotide binding] 1186051001253 phosphate binding site [ion binding]; other site 1186051001254 domain II; other site 1186051001255 domain III; other site 1186051001256 nucleotide binding site [chemical binding]; other site 1186051001257 catalytic site [active] 1186051001258 domain IV; other site 1186051001259 Predicted methyltransferases [General function prediction only]; Region: COG0313 1186051001260 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1186051001261 putative SAM binding site [chemical binding]; other site 1186051001262 putative homodimer interface [polypeptide binding]; other site 1186051001263 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1186051001264 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1186051001265 Guanylate kinase; Region: Guanylate_kin; pfam00625 1186051001266 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1186051001267 catalytic site [active] 1186051001268 G-X2-G-X-G-K; other site 1186051001269 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1186051001270 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1186051001271 Phosphoglycerate kinase; Region: PGK; pfam00162 1186051001272 substrate binding site [chemical binding]; other site 1186051001273 hinge regions; other site 1186051001274 ADP binding site [chemical binding]; other site 1186051001275 catalytic site [active] 1186051001276 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1186051001277 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1186051001278 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1186051001279 Dihydroneopterin aldolase; Region: FolB; smart00905 1186051001280 active site 1186051001281 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1186051001282 active site 1186051001283 Bacterial Ig-like domain; Region: Big_5; pfam13205 1186051001284 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1186051001285 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1186051001286 glutaminase active site [active] 1186051001287 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1186051001288 dimer interface [polypeptide binding]; other site 1186051001289 active site 1186051001290 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1186051001291 dimer interface [polypeptide binding]; other site 1186051001292 active site 1186051001293 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 1186051001294 ribonuclease R; Region: RNase_R; TIGR02063 1186051001295 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1186051001296 RNB domain; Region: RNB; pfam00773 1186051001297 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1186051001298 RNA binding site [nucleotide binding]; other site 1186051001299 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1186051001300 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051001301 active site 1186051001302 nucleotide binding site [chemical binding]; other site 1186051001303 HIGH motif; other site 1186051001304 KMSKS motif; other site 1186051001305 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1186051001306 Transglycosylase; Region: Transgly; pfam00912 1186051001307 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1186051001308 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1186051001309 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1186051001310 NAD binding site [chemical binding]; other site 1186051001311 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1186051001312 Flavodoxin; Region: Flavodoxin_1; pfam00258 1186051001313 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1186051001314 FAD binding pocket [chemical binding]; other site 1186051001315 conserved FAD binding motif [chemical binding]; other site 1186051001316 phosphate binding motif [ion binding]; other site 1186051001317 beta-alpha-beta structure motif; other site 1186051001318 NAD binding pocket [chemical binding]; other site 1186051001319 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1186051001320 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1186051001321 dimer interface [polypeptide binding]; other site 1186051001322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1186051001323 catalytic residue [active] 1186051001324 serine O-acetyltransferase; Region: cysE; TIGR01172 1186051001325 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1186051001326 trimer interface [polypeptide binding]; other site 1186051001327 active site 1186051001328 substrate binding site [chemical binding]; other site 1186051001329 CoA binding site [chemical binding]; other site 1186051001330 isocitrate dehydrogenase; Validated; Region: PRK08299 1186051001331 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1186051001332 acyl-activating enzyme (AAE) consensus motif; other site 1186051001333 AMP binding site [chemical binding]; other site 1186051001334 active site 1186051001335 CoA binding site [chemical binding]; other site 1186051001336 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1186051001337 metal binding site [ion binding]; metal-binding site 1186051001338 substrate binding pocket [chemical binding]; other site 1186051001339 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1186051001340 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1186051001341 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1186051001342 UbiA prenyltransferase family; Region: UbiA; pfam01040 1186051001343 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1186051001344 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1186051001345 substrate binding site [chemical binding]; other site 1186051001346 oxyanion hole (OAH) forming residues; other site 1186051001347 trimer interface [polypeptide binding]; other site 1186051001348 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 1186051001349 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1186051001350 enolase; Provisional; Region: eno; PRK00077 1186051001351 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1186051001352 dimer interface [polypeptide binding]; other site 1186051001353 metal binding site [ion binding]; metal-binding site 1186051001354 substrate binding pocket [chemical binding]; other site 1186051001355 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1186051001356 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1186051001357 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1186051001358 alphaNTD homodimer interface [polypeptide binding]; other site 1186051001359 alphaNTD - beta interaction site [polypeptide binding]; other site 1186051001360 alphaNTD - beta' interaction site [polypeptide binding]; other site 1186051001361 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1186051001362 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1186051001363 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1186051001364 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1186051001365 RNA binding surface [nucleotide binding]; other site 1186051001366 30S ribosomal protein S11; Validated; Region: PRK05309 1186051001367 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1186051001368 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1186051001369 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1186051001370 rRNA binding site [nucleotide binding]; other site 1186051001371 predicted 30S ribosome binding site; other site 1186051001372 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1186051001373 SecY translocase; Region: SecY; pfam00344 1186051001374 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1186051001375 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1186051001376 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1186051001377 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1186051001378 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1186051001379 5S rRNA interface [nucleotide binding]; other site 1186051001380 L27 interface [polypeptide binding]; other site 1186051001381 23S rRNA interface [nucleotide binding]; other site 1186051001382 L5 interface [polypeptide binding]; other site 1186051001383 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1186051001384 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1186051001385 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 1186051001386 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1186051001387 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1186051001388 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1186051001389 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1186051001390 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1186051001391 RNA binding site [nucleotide binding]; other site 1186051001392 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1186051001393 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1186051001394 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1186051001395 putative translocon interaction site; other site 1186051001396 23S rRNA interface [nucleotide binding]; other site 1186051001397 signal recognition particle (SRP54) interaction site; other site 1186051001398 L23 interface [polypeptide binding]; other site 1186051001399 trigger factor interaction site; other site 1186051001400 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1186051001401 23S rRNA interface [nucleotide binding]; other site 1186051001402 5S rRNA interface [nucleotide binding]; other site 1186051001403 putative antibiotic binding site [chemical binding]; other site 1186051001404 L25 interface [polypeptide binding]; other site 1186051001405 L27 interface [polypeptide binding]; other site 1186051001406 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1186051001407 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1186051001408 G-X-X-G motif; other site 1186051001409 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1186051001410 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1186051001411 putative translocon binding site; other site 1186051001412 protein-rRNA interface [nucleotide binding]; other site 1186051001413 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1186051001414 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1186051001415 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1186051001416 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1186051001417 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1186051001418 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1186051001419 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1186051001420 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1186051001421 elongation factor G; Reviewed; Region: PRK12739 1186051001422 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1186051001423 G1 box; other site 1186051001424 putative GEF interaction site [polypeptide binding]; other site 1186051001425 GTP/Mg2+ binding site [chemical binding]; other site 1186051001426 Switch I region; other site 1186051001427 G2 box; other site 1186051001428 G3 box; other site 1186051001429 Switch II region; other site 1186051001430 G4 box; other site 1186051001431 G5 box; other site 1186051001432 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1186051001433 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1186051001434 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1186051001435 30S ribosomal protein S7; Validated; Region: PRK05302 1186051001436 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1186051001437 S17 interaction site [polypeptide binding]; other site 1186051001438 S8 interaction site; other site 1186051001439 16S rRNA interaction site [nucleotide binding]; other site 1186051001440 streptomycin interaction site [chemical binding]; other site 1186051001441 23S rRNA interaction site [nucleotide binding]; other site 1186051001442 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1186051001443 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1186051001444 active site 1186051001445 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1186051001446 phosphoglyceromutase; Provisional; Region: PRK05434 1186051001447 elongation factor Ts; Provisional; Region: tsf; PRK09377 1186051001448 UBA/TS-N domain; Region: UBA; pfam00627 1186051001449 Elongation factor TS; Region: EF_TS; pfam00889 1186051001450 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1186051001451 rRNA interaction site [nucleotide binding]; other site 1186051001452 S8 interaction site; other site 1186051001453 putative laminin-1 binding site; other site 1186051001454 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1186051001455 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1186051001456 23S rRNA interface [nucleotide binding]; other site 1186051001457 L3 interface [polypeptide binding]; other site 1186051001458 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1186051001459 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1186051001460 nucleotide binding site [chemical binding]; other site 1186051001461 NEF interaction site [polypeptide binding]; other site 1186051001462 SBD interface [polypeptide binding]; other site 1186051001463 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1186051001464 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1186051001465 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1186051001466 FtsH Extracellular; Region: FtsH_ext; pfam06480 1186051001467 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1186051001468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1186051001469 Walker A motif; other site 1186051001470 ATP binding site [chemical binding]; other site 1186051001471 Walker B motif; other site 1186051001472 arginine finger; other site 1186051001473 Peptidase family M41; Region: Peptidase_M41; pfam01434 1186051001474 Oligomerisation domain; Region: Oligomerisation; pfam02410 1186051001475 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1186051001476 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1186051001477 membrane protein insertase; Provisional; Region: PRK01318 1186051001478 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1186051001479 CTP synthetase; Validated; Region: pyrG; PRK05380 1186051001480 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1186051001481 Catalytic site [active] 1186051001482 active site 1186051001483 UTP binding site [chemical binding]; other site 1186051001484 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1186051001485 active site 1186051001486 putative oxyanion hole; other site 1186051001487 catalytic triad [active] 1186051001488 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1186051001489 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1186051001490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1186051001491 Walker A motif; other site 1186051001492 ATP binding site [chemical binding]; other site 1186051001493 Walker B motif; other site 1186051001494 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1186051001495 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1186051001496 GTP1/OBG; Region: GTP1_OBG; pfam01018 1186051001497 Obg GTPase; Region: Obg; cd01898 1186051001498 G1 box; other site 1186051001499 GTP/Mg2+ binding site [chemical binding]; other site 1186051001500 Switch I region; other site 1186051001501 G2 box; other site 1186051001502 G3 box; other site 1186051001503 Switch II region; other site 1186051001504 G4 box; other site 1186051001505 G5 box; other site 1186051001506 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1186051001507 Adenylate kinase; Region: ADK; pfam00406 1186051001508 AMP-binding site [chemical binding]; other site 1186051001509 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1186051001510 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1186051001511 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1186051001512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1186051001513 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1186051001514 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1186051001515 active site 1186051001516 intersubunit interactions; other site 1186051001517 catalytic residue [active] 1186051001518 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1186051001519 Ferritin-like domain; Region: Ferritin; pfam00210 1186051001520 ferroxidase diiron center [ion binding]; other site 1186051001521 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1186051001522 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1186051001523 dimer interface [polypeptide binding]; other site 1186051001524 active site 1186051001525 catalytic residue [active] 1186051001526 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1186051001527 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 1186051001528 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1186051001529 active site 1186051001530 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 1186051001531 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1186051001532 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1186051001533 FeS/SAM binding site; other site 1186051001534 TRAM domain; Region: TRAM; cl01282 1186051001535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1186051001536 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1186051001537 Walker A motif; other site 1186051001538 ATP binding site [chemical binding]; other site 1186051001539 Walker B motif; other site 1186051001540 arginine finger; other site 1186051001541 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1186051001542 oligomerisation interface [polypeptide binding]; other site 1186051001543 mobile loop; other site 1186051001544 roof hairpin; other site 1186051001545 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1186051001546 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1186051001547 ring oligomerisation interface [polypeptide binding]; other site 1186051001548 ATP/Mg binding site [chemical binding]; other site 1186051001549 stacking interactions; other site 1186051001550 hinge regions; other site 1186051001551 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1186051001552 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 1186051001553 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1186051001554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1186051001555 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1186051001556 Walker A/P-loop; other site 1186051001557 ATP binding site [chemical binding]; other site 1186051001558 Q-loop/lid; other site 1186051001559 ABC transporter signature motif; other site 1186051001560 Walker B; other site 1186051001561 D-loop; other site 1186051001562 H-loop/switch region; other site 1186051001563 transcription antitermination factor NusB; Region: nusB; TIGR01951 1186051001564 Preprotein translocase subunit; Region: YajC; pfam02699 1186051001565 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1186051001566 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1186051001567 CoA-binding site [chemical binding]; other site 1186051001568 ATP-binding [chemical binding]; other site 1186051001569 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1186051001570 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1186051001571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1186051001572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1186051001573 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1186051001574 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1186051001575 CoenzymeA binding site [chemical binding]; other site 1186051001576 subunit interaction site [polypeptide binding]; other site 1186051001577 PHB binding site; other site 1186051001578 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1186051001579 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1186051001580 nudix motif; other site 1186051001581 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1186051001582 active site 1186051001583 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1186051001584 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1186051001585 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1186051001586 putative efflux protein, MATE family; Region: matE; TIGR00797 1186051001587 cation binding site [ion binding]; other site 1186051001588 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1186051001589 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1186051001590 ATP binding site [chemical binding]; other site 1186051001591 Mg++ binding site [ion binding]; other site 1186051001592 motif III; other site 1186051001593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1186051001594 nucleotide binding region [chemical binding]; other site 1186051001595 ATP-binding site [chemical binding]; other site 1186051001596 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1186051001597 RNA binding site [nucleotide binding]; other site 1186051001598 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1186051001599 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1186051001600 Tetramer interface [polypeptide binding]; other site 1186051001601 active site 1186051001602 FMN-binding site [chemical binding]; other site 1186051001603 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1186051001604 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1186051001605 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1186051001606 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1186051001607 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1186051001608 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051001609 active site 1186051001610 HIGH motif; other site 1186051001611 nucleotide binding site [chemical binding]; other site 1186051001612 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051001613 active site 1186051001614 KMSKS motif; other site 1186051001615 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1186051001616 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1186051001617 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1186051001618 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1186051001619 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1186051001620 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1186051001621 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1186051001622 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1186051001623 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1186051001624 DNA binding site [nucleotide binding] 1186051001625 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1186051001626 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1186051001627 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1186051001628 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1186051001629 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1186051001630 RPB11 interaction site [polypeptide binding]; other site 1186051001631 RPB12 interaction site [polypeptide binding]; other site 1186051001632 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1186051001633 RPB3 interaction site [polypeptide binding]; other site 1186051001634 RPB1 interaction site [polypeptide binding]; other site 1186051001635 RPB11 interaction site [polypeptide binding]; other site 1186051001636 RPB10 interaction site [polypeptide binding]; other site 1186051001637 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1186051001638 peripheral dimer interface [polypeptide binding]; other site 1186051001639 core dimer interface [polypeptide binding]; other site 1186051001640 L10 interface [polypeptide binding]; other site 1186051001641 L11 interface [polypeptide binding]; other site 1186051001642 putative EF-Tu interaction site [polypeptide binding]; other site 1186051001643 putative EF-G interaction site [polypeptide binding]; other site 1186051001644 Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with...; Region: Ribosomal_L10_P0; cl00376 1186051001645 23S rRNA interface [nucleotide binding]; other site 1186051001646 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1186051001647 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1186051001648 mRNA/rRNA interface [nucleotide binding]; other site 1186051001649 Ribosomal protein L11/L12; Region: RL11; smart00649 1186051001650 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1186051001651 putative thiostrepton binding site; other site 1186051001652 23S rRNA interface [nucleotide binding]; other site 1186051001653 L7/L12 interface [polypeptide binding]; other site 1186051001654 L25 interface [polypeptide binding]; other site 1186051001655 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1186051001656 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1186051001657 putative homodimer interface [polypeptide binding]; other site 1186051001658 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1186051001659 heterodimer interface [polypeptide binding]; other site 1186051001660 homodimer interface [polypeptide binding]; other site 1186051001661 elongation factor Tu; Reviewed; Region: PRK12735 1186051001662 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1186051001663 G1 box; other site 1186051001664 GEF interaction site [polypeptide binding]; other site 1186051001665 GTP/Mg2+ binding site [chemical binding]; other site 1186051001666 Switch I region; other site 1186051001667 G2 box; other site 1186051001668 G3 box; other site 1186051001669 Switch II region; other site 1186051001670 G4 box; other site 1186051001671 G5 box; other site 1186051001672 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1186051001673 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1186051001674 Antibiotic Binding Site [chemical binding]; other site 1186051001675 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1186051001676 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1186051001677 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 1186051001678 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051001679 active site 1186051001680 HIGH motif; other site 1186051001681 nucleotide binding site [chemical binding]; other site 1186051001682 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051001683 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051001684 active site 1186051001685 KMSKS motif; other site 1186051001686 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1186051001687 tRNA binding surface [nucleotide binding]; other site 1186051001688 anticodon binding site; other site 1186051001689 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1186051001690 MutS domain I; Region: MutS_I; pfam01624 1186051001691 MutS domain II; Region: MutS_II; pfam05188 1186051001692 MutS domain III; Region: MutS_III; pfam05192 1186051001693 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1186051001694 Walker A/P-loop; other site 1186051001695 ATP binding site [chemical binding]; other site 1186051001696 Q-loop/lid; other site 1186051001697 ABC transporter signature motif; other site 1186051001698 Walker B; other site 1186051001699 D-loop; other site 1186051001700 H-loop/switch region; other site 1186051001701 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1186051001702 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1186051001703 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1186051001704 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1186051001705 active site 1186051001706 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1186051001707 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1186051001708 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1186051001709 active site 1186051001710 substrate binding site [chemical binding]; other site 1186051001711 metal binding site [ion binding]; metal-binding site 1186051001712 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1186051001713 replicative DNA helicase; Region: DnaB; TIGR00665 1186051001714 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1186051001715 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1186051001716 Walker A motif; other site 1186051001717 ATP binding site [chemical binding]; other site 1186051001718 Walker B motif; other site 1186051001719 DNA binding loops [nucleotide binding] 1186051001720 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1186051001721 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1186051001722 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1186051001723 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1186051001724 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1186051001725 L-aspartate oxidase; Provisional; Region: PRK06175 1186051001726 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1186051001727 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1186051001728 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1186051001729 proximal heme binding site [chemical binding]; other site 1186051001730 distal heme binding site [chemical binding]; other site 1186051001731 putative dimer interface [polypeptide binding]; other site 1186051001732 putative Iron-sulfur protein interface [polypeptide binding]; other site 1186051001733 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1186051001734 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1186051001735 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1186051001736 catalytic residue [active] 1186051001737 phosphodiesterase; Provisional; Region: PRK12704 1186051001738 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1186051001739 deoxyhypusine synthase; Region: dhys; TIGR00321 1186051001740 Deoxyhypusine synthase; Region: DS; cl00826 1186051001741 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1186051001742 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1186051001743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1186051001744 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1186051001745 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1186051001746 ligand binding site [chemical binding]; other site 1186051001747 active site 1186051001748 UGI interface [polypeptide binding]; other site 1186051001749 catalytic site [active] 1186051001750 4Fe-4S binding domain; Region: Fer4; cl02805 1186051001751 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1186051001752 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1186051001753 catalytic motif [active] 1186051001754 Zn binding site [ion binding]; other site 1186051001755 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1186051001756 RibD C-terminal domain; Region: RibD_C; cl17279 1186051001757 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1186051001758 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1186051001759 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1186051001760 shikimate binding site; other site 1186051001761 NAD(P) binding site [chemical binding]; other site 1186051001762 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 1186051001763 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1186051001764 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1186051001765 generic binding surface II; other site 1186051001766 ssDNA binding site; other site 1186051001767 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1186051001768 ATP binding site [chemical binding]; other site 1186051001769 putative Mg++ binding site [ion binding]; other site 1186051001770 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1186051001771 nucleotide binding region [chemical binding]; other site 1186051001772 ATP-binding site [chemical binding]; other site 1186051001773 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1186051001774 Part of AAA domain; Region: AAA_19; pfam13245 1186051001775 Family description; Region: UvrD_C_2; pfam13538 1186051001776 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1186051001777 Cation efflux family; Region: Cation_efflux; pfam01545 1186051001778 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 1186051001779 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1186051001780 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1186051001781 hinge; other site 1186051001782 active site 1186051001783 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1186051001784 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1186051001785 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1186051001786 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1186051001787 nucleotide binding site/active site [active] 1186051001788 HIT family signature motif; other site 1186051001789 catalytic residue [active] 1186051001790 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1186051001791 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1186051001792 PGAP1-like protein; Region: PGAP1; pfam07819 1186051001793 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1186051001794 RIP metalloprotease RseP; Region: TIGR00054 1186051001795 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1186051001796 active site 1186051001797 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1186051001798 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1186051001799 protein binding site [polypeptide binding]; other site 1186051001800 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1186051001801 putative substrate binding region [chemical binding]; other site 1186051001802 FeoA domain; Region: FeoA; pfam04023 1186051001803 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1186051001804 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1186051001805 G1 box; other site 1186051001806 GTP/Mg2+ binding site [chemical binding]; other site 1186051001807 Switch I region; other site 1186051001808 G2 box; other site 1186051001809 G3 box; other site 1186051001810 Switch II region; other site 1186051001811 G4 box; other site 1186051001812 G5 box; other site 1186051001813 Nucleoside recognition; Region: Gate; pfam07670 1186051001814 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1186051001815 Nucleoside recognition; Region: Gate; pfam07670 1186051001816 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1186051001817 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1186051001818 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1186051001819 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1186051001820 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1186051001821 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1186051001822 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1186051001823 RNA binding surface [nucleotide binding]; other site 1186051001824 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1186051001825 active site 1186051001826 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1186051001827 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1186051001828 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1186051001829 Divalent cation transporter; Region: MgtE; pfam01769 1186051001830 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 1186051001831 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051001832 active site 1186051001833 HIGH motif; other site 1186051001834 nucleotide binding site [chemical binding]; other site 1186051001835 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1186051001836 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051001837 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1186051001838 active site 1186051001839 KMSKS motif; other site 1186051001840 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1186051001841 tRNA binding surface [nucleotide binding]; other site 1186051001842 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1186051001843 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1186051001844 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1186051001845 NAD(P) binding site [chemical binding]; other site 1186051001846 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1186051001847 putative nucleotide binding site [chemical binding]; other site 1186051001848 uridine monophosphate binding site [chemical binding]; other site 1186051001849 homohexameric interface [polypeptide binding]; other site 1186051001850 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 1186051001851 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1186051001852 hinge region; other site 1186051001853 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1186051001854 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1186051001855 Dimer interface [polypeptide binding]; other site 1186051001856 anticodon binding site; other site 1186051001857 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1186051001858 homodimer interface [polypeptide binding]; other site 1186051001859 motif 1; other site 1186051001860 motif 2; other site 1186051001861 active site 1186051001862 motif 3; other site 1186051001863 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1186051001864 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1186051001865 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1186051001866 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1186051001867 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1186051001868 NAD(P) binding site [chemical binding]; other site 1186051001869 catalytic residues [active] 1186051001870 Fe-S metabolism associated domain; Region: SufE; cl00951 1186051001871 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1186051001872 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1186051001873 THF binding site; other site 1186051001874 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1186051001875 substrate binding site [chemical binding]; other site 1186051001876 THF binding site; other site 1186051001877 zinc-binding site [ion binding]; other site 1186051001878 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 1186051001879 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 1186051001880 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1186051001881 putative trimer interface [polypeptide binding]; other site 1186051001882 putative CoA binding site [chemical binding]; other site 1186051001883 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1186051001884 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1186051001885 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1186051001886 active site 1186051001887 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1186051001888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1186051001889 S-adenosylmethionine binding site [chemical binding]; other site 1186051001890 GH3 auxin-responsive promoter; Region: GH3; pfam03321 1186051001891 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1186051001892 16S/18S rRNA binding site [nucleotide binding]; other site 1186051001893 S13e-L30e interaction site [polypeptide binding]; other site 1186051001894 25S rRNA binding site [nucleotide binding]; other site 1186051001895 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1186051001896 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1186051001897 oligomer interface [polypeptide binding]; other site 1186051001898 RNA binding site [nucleotide binding]; other site 1186051001899 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1186051001900 RNase E interface [polypeptide binding]; other site 1186051001901 trimer interface [polypeptide binding]; other site 1186051001902 active site 1186051001903 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1186051001904 putative nucleic acid binding region [nucleotide binding]; other site 1186051001905 G-X-X-G motif; other site 1186051001906 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1186051001907 RNA binding site [nucleotide binding]; other site 1186051001908 domain interface; other site 1186051001909 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 1186051001910 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1186051001911 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1186051001912 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1186051001913 DNA binding residues [nucleotide binding] 1186051001914 triosephosphate isomerase; Provisional; Region: PRK14567 1186051001915 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1186051001916 substrate binding site [chemical binding]; other site 1186051001917 dimer interface [polypeptide binding]; other site 1186051001918 catalytic triad [active] 1186051001919 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 1186051001920 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1186051001921 dihydropteroate synthase; Region: DHPS; TIGR01496 1186051001922 substrate binding pocket [chemical binding]; other site 1186051001923 dimer interface [polypeptide binding]; other site 1186051001924 inhibitor binding site; inhibition site 1186051001925 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1186051001926 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1186051001927 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1186051001928 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1186051001929 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1186051001930 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1186051001931 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1186051001932 tetramer interface [polypeptide binding]; other site 1186051001933 TPP-binding site [chemical binding]; other site 1186051001934 heterodimer interface [polypeptide binding]; other site 1186051001935 phosphorylation loop region [posttranslational modification] 1186051001936 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1186051001937 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1186051001938 E3 interaction surface; other site 1186051001939 lipoyl attachment site [posttranslational modification]; other site 1186051001940 e3 binding domain; Region: E3_binding; pfam02817 1186051001941 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1186051001942 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1186051001943 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1186051001944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1186051001945 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1186051001946 Walker A/P-loop; other site 1186051001947 ATP binding site [chemical binding]; other site 1186051001948 Q-loop/lid; other site 1186051001949 ABC transporter signature motif; other site 1186051001950 Walker B; other site 1186051001951 D-loop; other site 1186051001952 H-loop/switch region; other site 1186051001953 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1186051001954 Protein export membrane protein; Region: SecD_SecF; cl14618 1186051001955 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1186051001956 Protein export membrane protein; Region: SecD_SecF; pfam02355 1186051001957 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1186051001958 SurA N-terminal domain; Region: SurA_N_3; cl07813 1186051001959 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1186051001960 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1186051001961 Domain of unknown function DUF21; Region: DUF21; pfam01595 1186051001962 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1186051001963 Transporter associated domain; Region: CorC_HlyC; smart01091 1186051001964 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1186051001965 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1186051001966 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1186051001967 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1186051001968 Surface antigen; Region: Bac_surface_Ag; pfam01103 1186051001969 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1186051001970 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1186051001971 catalytic residue [active] 1186051001972 putative FPP diphosphate binding site; other site 1186051001973 putative FPP binding hydrophobic cleft; other site 1186051001974 dimer interface [polypeptide binding]; other site 1186051001975 putative IPP diphosphate binding site; other site 1186051001976 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1186051001977 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1186051001978 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1186051001979 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1186051001980 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1186051001981 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1186051001982 RNA binding surface [nucleotide binding]; other site 1186051001983 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1186051001984 active site 1186051001985 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1186051001986 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1186051001987 active site 1186051001988 trimer interface [polypeptide binding]; other site 1186051001989 dimer interface [polypeptide binding]; other site 1186051001990 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1186051001991 G1 box; other site 1186051001992 GTP/Mg2+ binding site [chemical binding]; other site 1186051001993 G2 box; other site 1186051001994 Switch I region; other site 1186051001995 G3 box; other site 1186051001996 Switch II region; other site 1186051001997 G4 box; other site 1186051001998 G5 box; other site 1186051001999 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1186051002000 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1186051002001 dimerization interface [polypeptide binding]; other site 1186051002002 active site 1186051002003 metal binding site [ion binding]; metal-binding site 1186051002004 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1186051002005 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1186051002006 dimer interface [polypeptide binding]; other site 1186051002007 active site 1186051002008 acyl carrier protein; Provisional; Region: acpP; PRK00982 1186051002009 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 1186051002010 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1186051002011 active site 1186051002012 metal-binding site [ion binding] 1186051002013 nucleotide-binding site [chemical binding]; other site 1186051002014 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1186051002015 Lumazine binding domain; Region: Lum_binding; pfam00677 1186051002016 Lumazine binding domain; Region: Lum_binding; pfam00677 1186051002017 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1186051002018 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1186051002019 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1186051002020 gamma subunit interface [polypeptide binding]; other site 1186051002021 LBP interface [polypeptide binding]; other site 1186051002022 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1186051002023 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1186051002024 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1186051002025 alpha subunit interaction interface [polypeptide binding]; other site 1186051002026 Walker A motif; other site 1186051002027 ATP binding site [chemical binding]; other site 1186051002028 Walker B motif; other site 1186051002029 inhibitor binding site; inhibition site 1186051002030 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1186051002031 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1186051002032 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1186051002033 active site 1186051002034 Riboflavin kinase; Region: Flavokinase; pfam01687 1186051002035 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1186051002036 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1186051002037 tartrate dehydrogenase; Region: TTC; TIGR02089 1186051002038 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1186051002039 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1186051002040 substrate binding site [chemical binding]; other site 1186051002041 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1186051002042 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1186051002043 substrate binding site [chemical binding]; other site 1186051002044 ligand binding site [chemical binding]; other site 1186051002045 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1186051002046 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1186051002047 active site 1186051002048 catalytic residues [active] 1186051002049 metal binding site [ion binding]; metal-binding site 1186051002050 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1186051002051 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1186051002052 active site 1186051002053 HIGH motif; other site 1186051002054 dimer interface [polypeptide binding]; other site 1186051002055 KMSKS motif; other site 1186051002056 putative GTP-binding protein (cell growth-related); frameshift mutation confirmed by PCR 1186051002057 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1186051002058 Clp amino terminal domain; Region: Clp_N; pfam02861 1186051002059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1186051002060 Walker A motif; other site 1186051002061 ATP binding site [chemical binding]; other site 1186051002062 Walker B motif; other site 1186051002063 arginine finger; other site 1186051002064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1186051002065 Walker A motif; other site 1186051002066 ATP binding site [chemical binding]; other site 1186051002067 Walker B motif; other site 1186051002068 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1186051002069 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1186051002070 PCRF domain; Region: PCRF; pfam03462 1186051002071 RF-1 domain; Region: RF-1; pfam00472 1186051002072 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1186051002073 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1186051002074 dimer interface [polypeptide binding]; other site 1186051002075 active site 1186051002076 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1186051002077 catalytic residues [active] 1186051002078 substrate binding site [chemical binding]; other site 1186051002079 agmatinase; Region: agmatinase; TIGR01230 1186051002080 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1186051002081 putative active site [active] 1186051002082 Mn binding site [ion binding]; other site 1186051002083 cytidylate kinase; Provisional; Region: cmk; PRK00023 1186051002084 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1186051002085 CMP-binding site; other site 1186051002086 The sites determining sugar specificity; other site 1186051002087 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1186051002088 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1186051002089 NAD(P) binding site [chemical binding]; other site 1186051002090 homotetramer interface [polypeptide binding]; other site 1186051002091 homodimer interface [polypeptide binding]; other site 1186051002092 active site 1186051002093 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1186051002094 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 1186051002095 dimer interface [polypeptide binding]; other site 1186051002096 tetramer interface [polypeptide binding]; other site 1186051002097 PYR/PP interface [polypeptide binding]; other site 1186051002098 TPP binding site [chemical binding]; other site 1186051002099 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1186051002100 TPP-binding site [chemical binding]; other site 1186051002101 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1186051002102 putative active site [active] 1186051002103 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 1186051002104 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1186051002105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1186051002106 nucleotide binding region [chemical binding]; other site 1186051002107 ATP-binding site [chemical binding]; other site 1186051002108 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1186051002109 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1186051002110 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1186051002111 putative active site [active] 1186051002112 substrate binding site [chemical binding]; other site 1186051002113 putative cosubstrate binding site; other site 1186051002114 catalytic site [active] 1186051002115 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1186051002116 substrate binding site [chemical binding]; other site 1186051002117 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1186051002118 IHF - DNA interface [nucleotide binding]; other site 1186051002119 IHF dimer interface [polypeptide binding]; other site 1186051002120 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1186051002121 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1186051002122 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1186051002123 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1186051002124 putative DNA binding surface [nucleotide binding]; other site 1186051002125 dimer interface [polypeptide binding]; other site 1186051002126 beta-clamp/clamp loader binding surface; other site 1186051002127 beta-clamp/translesion DNA polymerase binding surface; other site 1186051002128 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 1186051002129 B3/4 domain; Region: B3_4; pfam03483 1186051002130 tRNA synthetase B5 domain; Region: B5; smart00874 1186051002131 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1186051002132 motif 1; other site 1186051002133 dimer interface [polypeptide binding]; other site 1186051002134 active site 1186051002135 motif 2; other site 1186051002136 motif 3; other site 1186051002137 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1186051002138 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1186051002139 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1186051002140 motif 1; other site 1186051002141 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1186051002142 active site 1186051002143 dimer interface [polypeptide binding]; other site 1186051002144 motif 2; other site 1186051002145 motif 3; other site 1186051002146 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1186051002147 anticodon binding site; other site 1186051002148 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1186051002149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1186051002150 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1186051002151 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 1186051002152 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 1186051002153 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1186051002154 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1186051002155 GTP-binding protein LepA; Provisional; Region: PRK05433 1186051002156 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1186051002157 G1 box; other site 1186051002158 putative GEF interaction site [polypeptide binding]; other site 1186051002159 GTP/Mg2+ binding site [chemical binding]; other site 1186051002160 Switch I region; other site 1186051002161 G2 box; other site 1186051002162 G3 box; other site 1186051002163 Switch II region; other site 1186051002164 G4 box; other site 1186051002165 G5 box; other site 1186051002166 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1186051002167 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1186051002168 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1186051002169 peptidyl-tRNA hydrolase; Provisional; Region: PRK05426 1186051002170 putative active site [active] 1186051002171 catalytic residue [active] 1186051002172 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1186051002173 CoA binding domain; Region: CoA_binding; smart00881 1186051002174 CoA-ligase; Region: Ligase_CoA; pfam00549 1186051002175 elongation factor P; Validated; Region: PRK00529 1186051002176 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1186051002177 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1186051002178 RNA binding site [nucleotide binding]; other site 1186051002179 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1186051002180 RNA binding site [nucleotide binding]; other site 1186051002181 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 1186051002182 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 1186051002183 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1186051002184 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1186051002185 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1186051002186 active site 1186051002187 Zn binding site [ion binding]; other site 1186051002188 CAAX protease self-immunity; Region: Abi; pfam02517 1186051002189 ribonuclease Z; Reviewed; Region: PRK00055 1186051002190 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1186051002191 FtsX-like permease family; Region: FtsX; pfam02687 1186051002192 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1186051002193 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 1186051002194 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1186051002195 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1186051002196 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1186051002197 catalytic residue [active] 1186051002198 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1186051002199 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1186051002200 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1186051002201 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1186051002202 Walker A/P-loop; other site 1186051002203 ATP binding site [chemical binding]; other site 1186051002204 Q-loop/lid; other site 1186051002205 ABC transporter signature motif; other site 1186051002206 Walker B; other site 1186051002207 D-loop; other site 1186051002208 H-loop/switch region; other site 1186051002209 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1186051002210 putative ABC transporter; Region: ycf24; CHL00085 1186051002211 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1186051002212 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1186051002213 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1186051002214 Haemolytic domain; Region: Haemolytic; pfam01809 1186051002215 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 1186051002216 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1186051002217 substrate binding site [chemical binding]; other site 1186051002218 ligand binding site [chemical binding]; other site 1186051002219 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1186051002220 substrate binding site [chemical binding]; other site 1186051002221 PGAP1-like protein; Region: PGAP1; pfam07819 1186051002222 acyl-CoA esterase; Provisional; Region: PRK10673 1186051002223 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1186051002224 active site 1186051002225 hydrophilic channel; other site 1186051002226 dimerization interface [polypeptide binding]; other site 1186051002227 catalytic residues [active] 1186051002228 active site lid [active] 1186051002229 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1186051002230 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1186051002231 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1186051002232 trimer interface [polypeptide binding]; other site 1186051002233 active site 1186051002234 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 1186051002235 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1186051002236 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1186051002237 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1186051002238 dimer interface [polypeptide binding]; other site 1186051002239 putative radical transfer pathway; other site 1186051002240 diiron center [ion binding]; other site 1186051002241 tyrosyl radical; other site