-- dump date 20140619_003555 -- class Genbank::misc_feature -- table misc_feature_note -- id note 568707000001 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568707000002 Predicted transcriptional regulator [Transcription]; Region: COG2932 568707000003 Catalytic site [active] 568707000004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 568707000005 sequence-specific DNA binding site [nucleotide binding]; other site 568707000006 salt bridge; other site 568707000007 NinB protein; Region: NinB; pfam05772 568707000008 HNH endonuclease; Region: HNH_3; pfam13392 568707000009 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 568707000010 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 568707000011 Helix-turn-helix domain; Region: HTH_36; pfam13730 568707000012 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 568707000013 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 568707000014 active site 568707000015 putative DNA-binding cleft [nucleotide binding]; other site 568707000016 dimer interface [polypeptide binding]; other site 568707000017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 568707000018 DNA binding residues [nucleotide binding] 568707000019 Phage terminase large subunit; Region: Terminase_3; cl12054 568707000020 Terminase-like family; Region: Terminase_6; pfam03237 568707000021 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 568707000022 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 568707000023 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 568707000024 HNH endonuclease; Region: HNH_3; pfam13392 568707000025 Phage tail protein; Region: Phage_tail_3; pfam08813 568707000026 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 568707000027 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 568707000028 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 568707000029 Phage-related minor tail protein [Function unknown]; Region: COG5281 568707000030 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 568707000031 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 568707000032 Predicted transcriptional regulator [Transcription]; Region: COG2932 568707000033 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568707000034 Catalytic site [active] 568707000035 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568707000036 Catalytic site [active] 568707000037 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 568707000038 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 568707000039 AAA domain; Region: AAA_25; pfam13481 568707000040 Walker A motif; other site 568707000041 ATP binding site [chemical binding]; other site 568707000042 Walker B motif; other site 568707000043 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 568707000044 active site 568707000045 putative DNA-binding cleft [nucleotide binding]; other site 568707000046 dimer interface [polypeptide binding]; other site 568707000047 hypothetical protein; Region: PHA00687 568707000048 hypothetical protein; Region: PHA00675 568707000049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707000050 Coenzyme A binding pocket [chemical binding]; other site 568707000051 hypothetical protein; Region: PHA00672 568707000052 hypothetical protein; Region: PHA00671 568707000053 hypothetical protein; Region: PHA00670 568707000054 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 568707000055 putative protease; Region: PHA00666 568707000056 major capsid protein; Region: PHA00665 568707000057 hypothetical protein; Region: PHA00664 568707000058 hypothetical protein; Region: PHA00663 568707000059 hypothetical protein; Region: PHA00662 568707000060 hypothetical protein; Region: PHA00661 568707000061 putative lysin; Region: PHA00658 568707000062 hypothetical protein; Provisional; Region: PHA02515 568707000063 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 568707000064 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 568707000065 catalytic residue [active] 568707000066 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 568707000067 translocation protein TolB; Provisional; Region: tolB; PRK02889 568707000068 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 568707000069 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707000070 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568707000071 DNA-binding site [nucleotide binding]; DNA binding site 568707000072 RNA-binding motif; other site 568707000073 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 568707000074 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568707000075 DNA-binding site [nucleotide binding]; DNA binding site 568707000076 RNA-binding motif; other site 568707000077 hypothetical protein; Provisional; Region: PRK05208 568707000078 trigger factor; Provisional; Region: tig; PRK01490 568707000079 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 568707000080 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 568707000081 Clp protease; Region: CLP_protease; pfam00574 568707000082 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 568707000083 oligomer interface [polypeptide binding]; other site 568707000084 active site residues [active] 568707000085 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 568707000086 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 568707000087 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 568707000088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707000089 Walker A motif; other site 568707000090 ATP binding site [chemical binding]; other site 568707000091 Walker B motif; other site 568707000092 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568707000093 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 568707000094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707000095 Walker A motif; other site 568707000096 ATP binding site [chemical binding]; other site 568707000097 Walker B motif; other site 568707000098 arginine finger; other site 568707000099 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 568707000100 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 568707000101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707000102 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 568707000103 dimerization interface [polypeptide binding]; other site 568707000104 substrate binding pocket [chemical binding]; other site 568707000105 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707000106 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707000107 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707000108 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 568707000109 putative active site [active] 568707000110 putative catalytic site [active] 568707000111 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707000112 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707000113 substrate binding site [chemical binding]; other site 568707000114 oxyanion hole (OAH) forming residues; other site 568707000115 trimer interface [polypeptide binding]; other site 568707000116 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 568707000117 DUF35 OB-fold domain; Region: DUF35; pfam01796 568707000118 thiolase; Provisional; Region: PRK06158 568707000119 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 568707000120 active site 568707000121 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 568707000122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707000123 NAD(P) binding site [chemical binding]; other site 568707000124 active site 568707000125 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707000126 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707000127 active site 568707000128 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707000129 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 568707000130 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 568707000131 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707000132 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568707000133 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707000134 LexA repressor; Validated; Region: PRK00215 568707000135 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 568707000136 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568707000137 Catalytic site [active] 568707000138 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 568707000139 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707000140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707000141 homodimer interface [polypeptide binding]; other site 568707000142 catalytic residue [active] 568707000143 excinuclease ABC subunit B; Provisional; Region: PRK05298 568707000144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568707000145 ATP binding site [chemical binding]; other site 568707000146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568707000147 nucleotide binding region [chemical binding]; other site 568707000148 ATP-binding site [chemical binding]; other site 568707000149 Ultra-violet resistance protein B; Region: UvrB; pfam12344 568707000150 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 568707000151 Low molecular weight phosphatase family; Region: LMWPc; cd00115 568707000152 active site 568707000153 Predicted transcriptional regulator [Transcription]; Region: COG1959 568707000154 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 568707000155 cysteine desulfurase; Provisional; Region: PRK14012 568707000156 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 568707000157 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568707000158 catalytic residue [active] 568707000159 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 568707000160 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 568707000161 trimerization site [polypeptide binding]; other site 568707000162 active site 568707000163 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 568707000164 co-chaperone HscB; Provisional; Region: hscB; PRK03578 568707000165 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568707000166 HSP70 interaction site [polypeptide binding]; other site 568707000167 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 568707000168 chaperone protein HscA; Provisional; Region: hscA; PRK05183 568707000169 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 568707000170 nucleotide binding site [chemical binding]; other site 568707000171 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568707000172 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707000173 catalytic loop [active] 568707000174 iron binding site [ion binding]; other site 568707000175 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 568707000176 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 568707000177 active site 568707000178 dimer interfaces [polypeptide binding]; other site 568707000179 catalytic residues [active] 568707000180 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707000181 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707000182 substrate binding site [chemical binding]; other site 568707000183 oxyanion hole (OAH) forming residues; other site 568707000184 trimer interface [polypeptide binding]; other site 568707000185 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 568707000186 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707000187 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707000188 Walker A/P-loop; other site 568707000189 ATP binding site [chemical binding]; other site 568707000190 Q-loop/lid; other site 568707000191 ABC transporter signature motif; other site 568707000192 Walker B; other site 568707000193 D-loop; other site 568707000194 H-loop/switch region; other site 568707000195 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707000196 TM-ABC transporter signature motif; other site 568707000197 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707000198 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707000199 TM-ABC transporter signature motif; other site 568707000200 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 568707000201 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707000202 putative ligand binding site [chemical binding]; other site 568707000203 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707000204 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707000205 Walker A/P-loop; other site 568707000206 ATP binding site [chemical binding]; other site 568707000207 Q-loop/lid; other site 568707000208 ABC transporter signature motif; other site 568707000209 Walker B; other site 568707000210 D-loop; other site 568707000211 H-loop/switch region; other site 568707000212 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 568707000213 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707000214 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 568707000215 acyl-activating enzyme (AAE) consensus motif; other site 568707000216 putative AMP binding site [chemical binding]; other site 568707000217 putative active site [active] 568707000218 putative CoA binding site [chemical binding]; other site 568707000219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707000220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707000221 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 568707000222 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 568707000223 dimer interface [polypeptide binding]; other site 568707000224 putative anticodon binding site; other site 568707000225 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 568707000226 motif 1; other site 568707000227 active site 568707000228 motif 2; other site 568707000229 motif 3; other site 568707000230 short chain dehydrogenase; Provisional; Region: PRK07023 568707000231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707000232 NAD(P) binding site [chemical binding]; other site 568707000233 active site 568707000235 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 568707000236 DHH family; Region: DHH; pfam01368 568707000237 DHHA1 domain; Region: DHHA1; pfam02272 568707000238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 568707000239 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 568707000240 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568707000241 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 568707000242 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568707000243 Walker A/P-loop; other site 568707000244 ATP binding site [chemical binding]; other site 568707000245 Q-loop/lid; other site 568707000246 ABC transporter signature motif; other site 568707000247 Walker B; other site 568707000248 D-loop; other site 568707000249 H-loop/switch region; other site 568707000250 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 568707000251 active site 568707000252 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707000253 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 568707000254 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 568707000255 Competence protein; Region: Competence; pfam03772 568707000256 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 568707000257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568707000258 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 568707000259 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568707000260 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 568707000261 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 568707000262 active site 568707000263 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 568707000264 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 568707000265 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 568707000266 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568707000267 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707000268 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 568707000269 DctM-like transporters; Region: DctM; pfam06808 568707000270 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568707000271 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707000272 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 568707000273 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 568707000274 dimerization interface [polypeptide binding]; other site 568707000275 ATP binding site [chemical binding]; other site 568707000276 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 568707000277 dimerization interface [polypeptide binding]; other site 568707000278 ATP binding site [chemical binding]; other site 568707000279 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 568707000280 putative active site [active] 568707000281 catalytic triad [active] 568707000282 haemagglutination activity domain; Region: Haemagg_act; pfam05860 568707000283 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 568707000284 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 568707000285 hypothetical protein; Provisional; Region: PRK07907 568707000286 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 568707000287 metal binding site [ion binding]; metal-binding site 568707000288 putative dimer interface [polypeptide binding]; other site 568707000289 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 568707000290 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 568707000291 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 568707000292 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 568707000293 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707000294 Methyltransferase domain; Region: Methyltransf_32; pfam13679 568707000295 Methyltransferase domain; Region: Methyltransf_31; pfam13847 568707000296 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568707000297 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 568707000298 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 568707000299 catalytic residues [active] 568707000300 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 568707000301 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 568707000302 dimerization domain [polypeptide binding]; other site 568707000303 dimer interface [polypeptide binding]; other site 568707000304 catalytic residues [active] 568707000305 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568707000306 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707000307 dimerization interface [polypeptide binding]; other site 568707000308 DNA binding residues [nucleotide binding] 568707000310 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 568707000311 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 568707000312 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 568707000313 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 568707000314 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 568707000315 active site 568707000316 GMP synthase; Reviewed; Region: guaA; PRK00074 568707000317 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 568707000318 AMP/PPi binding site [chemical binding]; other site 568707000319 candidate oxyanion hole; other site 568707000320 catalytic triad [active] 568707000321 potential glutamine specificity residues [chemical binding]; other site 568707000322 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 568707000323 ATP Binding subdomain [chemical binding]; other site 568707000324 Ligand Binding sites [chemical binding]; other site 568707000325 Dimerization subdomain; other site 568707000326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707000327 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707000328 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568707000329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707000330 putative substrate translocation pore; other site 568707000331 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 568707000332 gating phenylalanine in ion channel; other site 568707000333 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707000334 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707000335 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707000336 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 568707000337 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 568707000338 active site 568707000339 NMT1-like family; Region: NMT1_2; pfam13379 568707000340 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568707000341 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707000342 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 568707000343 Walker A/P-loop; other site 568707000344 ATP binding site [chemical binding]; other site 568707000345 Q-loop/lid; other site 568707000346 ABC transporter signature motif; other site 568707000347 Walker B; other site 568707000348 D-loop; other site 568707000349 H-loop/switch region; other site 568707000350 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707000351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707000352 dimer interface [polypeptide binding]; other site 568707000353 conserved gate region; other site 568707000354 putative PBP binding loops; other site 568707000355 ABC-ATPase subunit interface; other site 568707000356 Protein of unknown function (DUF521); Region: DUF521; pfam04412 568707000357 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 568707000358 substrate binding site [chemical binding]; other site 568707000359 ligand binding site [chemical binding]; other site 568707000360 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 568707000361 conserved cys residue [active] 568707000362 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 568707000363 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 568707000364 Sulfate transporter family; Region: Sulfate_transp; pfam00916 568707000365 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 568707000366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 568707000367 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 568707000368 Beta-Casp domain; Region: Beta-Casp; smart01027 568707000369 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 568707000370 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 568707000371 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 568707000372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707000373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707000374 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707000375 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 568707000376 Amidohydrolase; Region: Amidohydro_2; pfam04909 568707000377 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707000378 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707000379 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707000380 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707000381 thiolase; Provisional; Region: PRK06158 568707000382 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 568707000383 active site 568707000384 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 568707000385 DUF35 OB-fold domain; Region: DUF35; pfam01796 568707000386 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 568707000387 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 568707000388 active site 568707000389 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 568707000390 succinic semialdehyde dehydrogenase; Region: PLN02278 568707000391 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 568707000392 tetramerization interface [polypeptide binding]; other site 568707000393 NAD(P) binding site [chemical binding]; other site 568707000394 catalytic residues [active] 568707000395 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 568707000396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707000397 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 568707000398 substrate binding pocket [chemical binding]; other site 568707000399 dimerization interface [polypeptide binding]; other site 568707000400 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 568707000401 Amidohydrolase; Region: Amidohydro_2; pfam04909 568707000402 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707000403 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 568707000404 Predicted membrane protein [Function unknown]; Region: COG1289 568707000405 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 568707000406 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 568707000407 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 568707000408 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 568707000409 conserved cys residue [active] 568707000410 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707000411 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 568707000412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707000413 DNA-binding site [nucleotide binding]; DNA binding site 568707000414 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707000415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707000416 homodimer interface [polypeptide binding]; other site 568707000417 catalytic residue [active] 568707000418 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 568707000419 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 568707000420 Uncharacterized conserved protein [Function unknown]; Region: COG5649 568707000421 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 568707000422 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 568707000423 metal binding site [ion binding]; metal-binding site 568707000424 dimer interface [polypeptide binding]; other site 568707000425 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568707000426 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 568707000427 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707000428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707000429 dimer interface [polypeptide binding]; other site 568707000430 conserved gate region; other site 568707000431 putative PBP binding loops; other site 568707000432 ABC-ATPase subunit interface; other site 568707000433 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568707000434 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568707000435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707000436 dimer interface [polypeptide binding]; other site 568707000437 conserved gate region; other site 568707000438 putative PBP binding loops; other site 568707000439 ABC-ATPase subunit interface; other site 568707000440 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 568707000441 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707000442 Walker A/P-loop; other site 568707000443 ATP binding site [chemical binding]; other site 568707000444 Q-loop/lid; other site 568707000445 ABC transporter signature motif; other site 568707000446 Walker B; other site 568707000447 D-loop; other site 568707000448 H-loop/switch region; other site 568707000449 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707000450 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707000451 Walker A/P-loop; other site 568707000452 ATP binding site [chemical binding]; other site 568707000453 Q-loop/lid; other site 568707000454 ABC transporter signature motif; other site 568707000455 Walker B; other site 568707000456 D-loop; other site 568707000457 H-loop/switch region; other site 568707000458 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707000459 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568707000460 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568707000461 DNA binding site [nucleotide binding] 568707000462 domain linker motif; other site 568707000463 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 568707000464 dimerization interface [polypeptide binding]; other site 568707000465 ligand binding site [chemical binding]; other site 568707000467 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 568707000468 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707000469 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707000470 enoyl-CoA hydratase; Region: PLN02864 568707000471 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 568707000472 dimer interaction site [polypeptide binding]; other site 568707000473 substrate-binding tunnel; other site 568707000474 active site 568707000475 catalytic site [active] 568707000476 substrate binding site [chemical binding]; other site 568707000477 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707000478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707000479 DNA-binding site [nucleotide binding]; DNA binding site 568707000480 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707000481 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568707000482 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707000483 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 568707000484 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568707000485 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568707000486 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 568707000487 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 568707000488 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707000489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707000490 DNA-binding site [nucleotide binding]; DNA binding site 568707000491 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568707000492 Bacteriophage protein GP30.3; Region: Phage_30_3; cl17603 568707000493 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 568707000494 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568707000495 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 568707000496 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 568707000497 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568707000498 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 568707000499 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 568707000500 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568707000501 Walker A/P-loop; other site 568707000502 ATP binding site [chemical binding]; other site 568707000503 Q-loop/lid; other site 568707000504 ABC transporter signature motif; other site 568707000505 Walker B; other site 568707000506 D-loop; other site 568707000507 H-loop/switch region; other site 568707000508 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 568707000509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707000510 Walker A/P-loop; other site 568707000511 ATP binding site [chemical binding]; other site 568707000512 Q-loop/lid; other site 568707000513 ABC transporter signature motif; other site 568707000514 Walker B; other site 568707000515 D-loop; other site 568707000516 H-loop/switch region; other site 568707000517 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 568707000518 HlyD family secretion protein; Region: HlyD_3; pfam13437 568707000519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707000520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707000521 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 568707000522 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 568707000523 putative active site [active] 568707000524 putative metal binding site [ion binding]; other site 568707000525 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568707000526 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568707000527 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568707000528 active site 568707000529 catalytic tetrad [active] 568707000530 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 568707000531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 568707000532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707000533 Walker A motif; other site 568707000534 ATP binding site [chemical binding]; other site 568707000535 Walker B motif; other site 568707000536 arginine finger; other site 568707000537 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568707000538 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 568707000539 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707000540 NAD(P) binding site [chemical binding]; other site 568707000541 catalytic residues [active] 568707000542 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 568707000543 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568707000545 Predicted membrane protein [Function unknown]; Region: COG2733 568707000546 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 568707000547 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 568707000548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707000549 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707000550 dimerization interface [polypeptide binding]; other site 568707000551 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 568707000552 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 568707000553 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 568707000554 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 568707000555 conserved cys residue [active] 568707000556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707000557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707000558 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 568707000559 Domain of unknown function DUF302; Region: DUF302; cl01364 568707000560 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568707000561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707000562 dimerization interface [polypeptide binding]; other site 568707000563 putative DNA binding site [nucleotide binding]; other site 568707000564 putative Zn2+ binding site [ion binding]; other site 568707000565 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 568707000566 putative hydrophobic ligand binding site [chemical binding]; other site 568707000567 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 568707000568 putative transporter; Provisional; Region: PRK11660 568707000569 Sulfate transporter family; Region: Sulfate_transp; pfam00916 568707000570 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 568707000571 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707000572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707000573 DNA-binding site [nucleotide binding]; DNA binding site 568707000574 FCD domain; Region: FCD; pfam07729 568707000575 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 568707000576 ZIP Zinc transporter; Region: Zip; pfam02535 568707000577 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568707000578 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568707000579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707000580 Walker A/P-loop; other site 568707000581 ATP binding site [chemical binding]; other site 568707000582 Q-loop/lid; other site 568707000583 ABC transporter signature motif; other site 568707000584 Walker B; other site 568707000585 D-loop; other site 568707000586 H-loop/switch region; other site 568707000587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568707000588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707000589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568707000590 Coenzyme A binding pocket [chemical binding]; other site 568707000591 Uncharacterized conserved protein [Function unknown]; Region: COG3791 568707000592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707000593 putative substrate translocation pore; other site 568707000594 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568707000595 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 568707000596 dimer interface [polypeptide binding]; other site 568707000597 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 568707000598 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 568707000599 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 568707000600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707000601 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 568707000602 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 568707000603 XdhC Rossmann domain; Region: XdhC_C; pfam13478 568707000604 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 568707000605 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 568707000606 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 568707000607 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 568707000608 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 568707000609 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 568707000610 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707000611 catalytic loop [active] 568707000612 iron binding site [ion binding]; other site 568707000613 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 568707000614 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 568707000615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707000616 LysR family transcriptional regulator; Provisional; Region: PRK14997 568707000617 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 568707000618 putative effector binding pocket; other site 568707000619 putative dimerization interface [polypeptide binding]; other site 568707000620 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 568707000621 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 568707000622 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 568707000623 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 568707000624 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 568707000625 glutathione reductase; Validated; Region: PRK06116 568707000626 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568707000627 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707000628 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568707000629 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 568707000630 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 568707000631 C-terminal domain interface [polypeptide binding]; other site 568707000632 GSH binding site (G-site) [chemical binding]; other site 568707000633 dimer interface [polypeptide binding]; other site 568707000634 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 568707000635 N-terminal domain interface [polypeptide binding]; other site 568707000636 putative dimer interface [polypeptide binding]; other site 568707000637 active site 568707000638 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 568707000639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707000640 DNA-binding site [nucleotide binding]; DNA binding site 568707000641 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707000642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707000643 homodimer interface [polypeptide binding]; other site 568707000644 catalytic residue [active] 568707000645 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 568707000646 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568707000647 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568707000648 EamA-like transporter family; Region: EamA; pfam00892 568707000649 EamA-like transporter family; Region: EamA; pfam00892 568707000650 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568707000651 catalytic residues [active] 568707000652 allantoate amidohydrolase; Reviewed; Region: PRK12890 568707000653 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 568707000654 active site 568707000655 metal binding site [ion binding]; metal-binding site 568707000656 dimer interface [polypeptide binding]; other site 568707000657 multidrug efflux protein; Reviewed; Region: PRK01766 568707000658 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 568707000659 cation binding site [ion binding]; other site 568707000660 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 568707000661 active site 568707000662 substrate-binding site [chemical binding]; other site 568707000663 metal-binding site [ion binding] 568707000664 GTP binding site [chemical binding]; other site 568707000665 Methyltransferase domain; Region: Methyltransf_23; pfam13489 568707000666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707000667 S-adenosylmethionine binding site [chemical binding]; other site 568707000668 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 568707000669 putative active site [active] 568707000670 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 568707000671 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568707000672 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 568707000673 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568707000674 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707000675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707000676 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 568707000677 putative dimerization interface [polypeptide binding]; other site 568707000678 DctM-like transporters; Region: DctM; pfam06808 568707000679 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568707000680 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707000681 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707000682 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707000683 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568707000684 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 568707000685 putative NAD(P) binding site [chemical binding]; other site 568707000686 active site 568707000687 putative substrate binding site [chemical binding]; other site 568707000688 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 568707000689 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568707000690 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568707000691 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 568707000692 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707000693 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707000694 DNA-binding site [nucleotide binding]; DNA binding site 568707000695 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568707000696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707000697 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 568707000698 DNA-binding site [nucleotide binding]; DNA binding site 568707000699 FCD domain; Region: FCD; pfam07729 568707000700 dihydroxy-acid dehydratase; Validated; Region: PRK06131 568707000701 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707000702 choline dehydrogenase; Validated; Region: PRK02106 568707000703 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 568707000704 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 568707000705 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707000706 substrate binding pocket [chemical binding]; other site 568707000707 membrane-bound complex binding site; other site 568707000708 hinge residues; other site 568707000709 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707000710 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707000711 Walker A/P-loop; other site 568707000712 ATP binding site [chemical binding]; other site 568707000713 Q-loop/lid; other site 568707000714 ABC transporter signature motif; other site 568707000715 Walker B; other site 568707000716 D-loop; other site 568707000717 H-loop/switch region; other site 568707000718 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707000719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707000720 dimer interface [polypeptide binding]; other site 568707000721 conserved gate region; other site 568707000722 putative PBP binding loops; other site 568707000723 ABC-ATPase subunit interface; other site 568707000724 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 568707000725 catalytic site [active] 568707000726 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707000727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707000728 DNA-binding site [nucleotide binding]; DNA binding site 568707000729 UTRA domain; Region: UTRA; pfam07702 568707000730 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 568707000731 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 568707000732 active site pocket [active] 568707000733 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707000734 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707000735 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 568707000736 putative effector binding pocket; other site 568707000737 putative dimerization interface [polypeptide binding]; other site 568707000738 short chain dehydrogenase; Provisional; Region: PRK12937 568707000739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707000740 NAD(P) binding site [chemical binding]; other site 568707000741 active site 568707000742 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 568707000743 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 568707000744 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568707000745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707000746 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707000747 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 568707000748 putative dimerization interface [polypeptide binding]; other site 568707000749 Sulfatase; Region: Sulfatase; cl17466 568707000750 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 568707000751 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707000752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 568707000753 MarR family; Region: MarR_2; pfam12802 568707000754 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 568707000755 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 568707000756 Cupin; Region: Cupin_6; pfam12852 568707000757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707000758 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568707000759 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 568707000760 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 568707000761 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 568707000763 Protein of unknown function, DUF488; Region: DUF488; pfam04343 568707000764 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 568707000765 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 568707000766 DctM-like transporters; Region: DctM; pfam06808 568707000767 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568707000768 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707000769 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707000770 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707000771 Isochorismatase family; Region: Isochorismatase; pfam00857 568707000772 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 568707000773 catalytic triad [active] 568707000774 conserved cis-peptide bond; other site 568707000775 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568707000776 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568707000777 ligand binding site [chemical binding]; other site 568707000778 flexible hinge region; other site 568707000779 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 568707000780 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707000781 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 568707000782 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 568707000783 active site 568707000784 catalytic site [active] 568707000785 Zn binding site [ion binding]; other site 568707000786 tetramer interface [polypeptide binding]; other site 568707000787 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568707000788 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568707000789 Amidase; Region: Amidase; cl11426 568707000790 classical (c) SDRs; Region: SDR_c; cd05233 568707000791 NAD(P) binding site [chemical binding]; other site 568707000792 short chain dehydrogenase; Provisional; Region: PRK07577 568707000793 active site 568707000794 Uncharacterized conserved protein [Function unknown]; Region: COG5476 568707000795 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 568707000796 MlrC C-terminus; Region: MlrC_C; pfam07171 568707000797 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 568707000798 putative catalytic site [active] 568707000799 putative phosphate binding site [ion binding]; other site 568707000800 active site 568707000801 metal binding site A [ion binding]; metal-binding site 568707000802 DNA binding site [nucleotide binding] 568707000803 putative AP binding site [nucleotide binding]; other site 568707000804 putative metal binding site B [ion binding]; other site 568707000805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 568707000806 NnrS protein; Region: NnrS; pfam05940 568707000807 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 568707000808 apolar tunnel; other site 568707000809 heme binding site [chemical binding]; other site 568707000810 dimerization interface [polypeptide binding]; other site 568707000811 Rdx family; Region: Rdx; cl01407 568707000812 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568707000813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707000814 Walker A/P-loop; other site 568707000815 ATP binding site [chemical binding]; other site 568707000816 Q-loop/lid; other site 568707000817 ABC transporter signature motif; other site 568707000818 Walker B; other site 568707000819 D-loop; other site 568707000820 H-loop/switch region; other site 568707000821 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568707000822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707000823 dimer interface [polypeptide binding]; other site 568707000824 conserved gate region; other site 568707000825 putative PBP binding loops; other site 568707000826 ABC-ATPase subunit interface; other site 568707000827 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568707000828 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707000829 substrate binding pocket [chemical binding]; other site 568707000830 membrane-bound complex binding site; other site 568707000831 hinge residues; other site 568707000832 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 568707000833 Heavy-metal-associated domain; Region: HMA; pfam00403 568707000834 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568707000835 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 568707000836 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 568707000837 DNA binding residues [nucleotide binding] 568707000838 dimer interface [polypeptide binding]; other site 568707000839 putative metal binding site [ion binding]; other site 568707000840 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 568707000841 putative FMN binding site [chemical binding]; other site 568707000842 argininosuccinate lyase; Provisional; Region: PRK00855 568707000843 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 568707000844 active sites [active] 568707000845 tetramer interface [polypeptide binding]; other site 568707000846 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 568707000847 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 568707000848 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568707000849 NAD synthetase; Provisional; Region: PRK13981 568707000850 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 568707000851 multimer interface [polypeptide binding]; other site 568707000852 active site 568707000853 catalytic triad [active] 568707000854 protein interface 1 [polypeptide binding]; other site 568707000855 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 568707000856 homodimer interface [polypeptide binding]; other site 568707000857 NAD binding pocket [chemical binding]; other site 568707000858 ATP binding pocket [chemical binding]; other site 568707000859 Mg binding site [ion binding]; other site 568707000860 active-site loop [active] 568707000862 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 568707000863 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568707000864 RNA binding surface [nucleotide binding]; other site 568707000865 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 568707000866 AAA domain; Region: AAA_17; pfam13207 568707000867 AAA domain; Region: AAA_18; pfam13238 568707000868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707000869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707000870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707000871 dimerization interface [polypeptide binding]; other site 568707000872 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 568707000873 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 568707000874 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568707000875 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 568707000876 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707000877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707000878 dimer interface [polypeptide binding]; other site 568707000879 conserved gate region; other site 568707000880 putative PBP binding loops; other site 568707000881 ABC-ATPase subunit interface; other site 568707000882 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568707000883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707000884 dimer interface [polypeptide binding]; other site 568707000885 conserved gate region; other site 568707000886 putative PBP binding loops; other site 568707000887 ABC-ATPase subunit interface; other site 568707000888 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 568707000889 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707000890 Walker A/P-loop; other site 568707000891 ATP binding site [chemical binding]; other site 568707000892 Q-loop/lid; other site 568707000893 ABC transporter signature motif; other site 568707000894 Walker B; other site 568707000895 D-loop; other site 568707000896 H-loop/switch region; other site 568707000897 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707000898 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707000899 Walker A/P-loop; other site 568707000900 ATP binding site [chemical binding]; other site 568707000901 Q-loop/lid; other site 568707000902 ABC transporter signature motif; other site 568707000903 Walker B; other site 568707000904 D-loop; other site 568707000905 H-loop/switch region; other site 568707000906 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707000907 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 568707000908 YaeQ protein; Region: YaeQ; pfam07152 568707000910 Chorismate lyase; Region: Chor_lyase; cl01230 568707000911 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 568707000912 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568707000913 RNA binding surface [nucleotide binding]; other site 568707000914 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 568707000915 active site 568707000916 transcriptional regulator; Provisional; Region: PRK10632 568707000917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707000918 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568707000919 putative effector binding pocket; other site 568707000920 dimerization interface [polypeptide binding]; other site 568707000921 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 568707000922 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568707000923 HlyD family secretion protein; Region: HlyD_3; pfam13437 568707000924 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 568707000925 Protein export membrane protein; Region: SecD_SecF; cl14618 568707000926 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 568707000927 Predicted membrane protein [Function unknown]; Region: COG2261 568707000928 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 568707000929 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 568707000930 Cu(I) binding site [ion binding]; other site 568707000931 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 568707000932 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 568707000933 active site 568707000934 Zn binding site [ion binding]; other site 568707000935 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 568707000936 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 568707000937 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 568707000938 homodimer interface [polypeptide binding]; other site 568707000939 NADP binding site [chemical binding]; other site 568707000940 substrate binding site [chemical binding]; other site 568707000941 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 568707000942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707000943 active site 568707000944 phosphorylation site [posttranslational modification] 568707000945 intermolecular recognition site; other site 568707000946 dimerization interface [polypeptide binding]; other site 568707000947 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707000948 DNA binding residues [nucleotide binding] 568707000949 dimerization interface [polypeptide binding]; other site 568707000950 PAS domain S-box; Region: sensory_box; TIGR00229 568707000951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568707000952 putative active site [active] 568707000953 heme pocket [chemical binding]; other site 568707000954 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 568707000955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707000956 dimer interface [polypeptide binding]; other site 568707000957 phosphorylation site [posttranslational modification] 568707000958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707000959 ATP binding site [chemical binding]; other site 568707000960 Mg2+ binding site [ion binding]; other site 568707000961 G-X-G motif; other site 568707000962 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 568707000963 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 568707000964 dimer interface [polypeptide binding]; other site 568707000965 TPP-binding site [chemical binding]; other site 568707000966 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 568707000967 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 568707000968 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568707000969 E3 interaction surface; other site 568707000970 lipoyl attachment site [posttranslational modification]; other site 568707000971 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568707000972 E3 interaction surface; other site 568707000973 lipoyl attachment site [posttranslational modification]; other site 568707000974 e3 binding domain; Region: E3_binding; pfam02817 568707000975 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 568707000976 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568707000977 E3 interaction surface; other site 568707000978 lipoyl attachment site [posttranslational modification]; other site 568707000979 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 568707000980 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707000981 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568707000982 flagellin; Validated; Region: PRK06819 568707000983 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 568707000984 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 568707000985 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 568707000986 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707000987 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 568707000988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568707000989 DNA binding residues [nucleotide binding] 568707000990 transcriptional activator FlhD; Provisional; Region: PRK02909 568707000991 transcriptional activator FlhC; Provisional; Region: PRK12722 568707000992 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 568707000993 flagellar motor protein MotA; Validated; Region: PRK09110 568707000994 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 568707000995 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 568707000996 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568707000997 ligand binding site [chemical binding]; other site 568707000998 Response regulator receiver domain; Region: Response_reg; pfam00072 568707000999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707001000 active site 568707001001 phosphorylation site [posttranslational modification] 568707001002 intermolecular recognition site; other site 568707001003 dimerization interface [polypeptide binding]; other site 568707001004 chemotaxis protein CheA; Provisional; Region: PRK10547 568707001005 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 568707001006 putative binding surface; other site 568707001007 active site 568707001008 CheY binding; Region: CheY-binding; pfam09078 568707001009 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 568707001010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707001011 ATP binding site [chemical binding]; other site 568707001012 Mg2+ binding site [ion binding]; other site 568707001013 G-X-G motif; other site 568707001014 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 568707001015 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 568707001016 putative CheA interaction surface; other site 568707001017 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 568707001018 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 568707001019 dimer interface [polypeptide binding]; other site 568707001020 ligand binding site [chemical binding]; other site 568707001021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707001022 dimerization interface [polypeptide binding]; other site 568707001023 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568707001024 dimer interface [polypeptide binding]; other site 568707001025 putative CheW interface [polypeptide binding]; other site 568707001026 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 568707001027 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 568707001028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707001029 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 568707001030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707001031 active site 568707001032 phosphorylation site [posttranslational modification] 568707001033 intermolecular recognition site; other site 568707001034 dimerization interface [polypeptide binding]; other site 568707001035 CheB methylesterase; Region: CheB_methylest; pfam01339 568707001036 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 568707001037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707001038 active site 568707001039 phosphorylation site [posttranslational modification] 568707001040 intermolecular recognition site; other site 568707001041 dimerization interface [polypeptide binding]; other site 568707001042 chemotaxis regulator CheZ; Provisional; Region: PRK11166 568707001043 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 568707001044 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 568707001045 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 568707001046 FHIPEP family; Region: FHIPEP; pfam00771 568707001047 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 568707001048 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 568707001049 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568707001050 FlgN protein; Region: FlgN; pfam05130 568707001051 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 568707001052 SAF-like; Region: SAF_2; pfam13144 568707001053 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 568707001054 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 568707001055 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 568707001056 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 568707001057 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 568707001058 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 568707001059 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK12633 568707001060 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 568707001061 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 568707001062 flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637 568707001063 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 568707001064 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 568707001065 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 568707001066 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 568707001067 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 568707001068 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 568707001069 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 568707001070 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 568707001071 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 568707001072 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12700 568707001073 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 568707001074 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 568707001075 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 568707001076 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12713 568707001077 Rod binding protein; Region: Rod-binding; cl01626 568707001078 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 568707001079 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 568707001080 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 568707001081 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12718 568707001082 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 568707001083 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 568707001084 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 568707001085 dimer interface [polypeptide binding]; other site 568707001086 ligand binding site [chemical binding]; other site 568707001087 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707001088 dimerization interface [polypeptide binding]; other site 568707001089 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568707001090 dimer interface [polypeptide binding]; other site 568707001091 putative CheW interface [polypeptide binding]; other site 568707001092 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 568707001093 dimer interface [polypeptide binding]; other site 568707001094 ligand binding site [chemical binding]; other site 568707001095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707001096 dimerization interface [polypeptide binding]; other site 568707001097 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 568707001098 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568707001099 dimer interface [polypeptide binding]; other site 568707001100 putative CheW interface [polypeptide binding]; other site 568707001101 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 568707001102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707001103 dimerization interface [polypeptide binding]; other site 568707001104 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568707001105 dimer interface [polypeptide binding]; other site 568707001106 putative CheW interface [polypeptide binding]; other site 568707001107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568707001108 PAS fold; Region: PAS_3; pfam08447 568707001109 putative active site [active] 568707001110 heme pocket [chemical binding]; other site 568707001111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707001112 dimerization interface [polypeptide binding]; other site 568707001113 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 568707001114 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568707001115 dimer interface [polypeptide binding]; other site 568707001116 putative CheW interface [polypeptide binding]; other site 568707001117 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 568707001118 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 568707001119 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 568707001120 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 568707001121 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 568707001123 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 568707001124 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 568707001125 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 568707001126 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 568707001127 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 568707001128 Walker A motif/ATP binding site; other site 568707001129 Walker B motif; other site 568707001130 flagellar assembly protein H; Validated; Region: fliH; PRK05687 568707001131 Flagellar assembly protein FliH; Region: FliH; pfam02108 568707001132 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 568707001133 FliG C-terminal domain; Region: FliG_C; pfam01706 568707001134 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 568707001135 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 568707001136 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 568707001137 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 568707001138 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 568707001139 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 568707001140 Flagellar protein FliT; Region: FliT; pfam05400 568707001141 Flagellar protein FliS; Region: FliS; cl00654 568707001142 flagellar capping protein; Reviewed; Region: fliD; PRK08032 568707001143 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 568707001144 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 568707001145 FlaG protein; Region: FlaG; pfam03646 568707001146 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 568707001147 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568707001148 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568707001149 Sporulation related domain; Region: SPOR; pfam05036 568707001150 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 568707001151 Colicin V production protein; Region: Colicin_V; pfam02674 568707001152 amidophosphoribosyltransferase; Provisional; Region: PRK09246 568707001153 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 568707001154 active site 568707001155 tetramer interface [polypeptide binding]; other site 568707001156 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568707001157 active site 568707001158 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 568707001159 MarC family integral membrane protein; Region: MarC; cl00919 568707001160 PII uridylyl-transferase; Provisional; Region: PRK03059 568707001161 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 568707001162 metal binding triad; other site 568707001163 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 568707001164 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568707001165 Zn2+ binding site [ion binding]; other site 568707001166 Mg2+ binding site [ion binding]; other site 568707001167 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 568707001168 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 568707001169 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 568707001170 active site 568707001171 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 568707001172 rRNA interaction site [nucleotide binding]; other site 568707001173 S8 interaction site; other site 568707001174 putative laminin-1 binding site; other site 568707001175 elongation factor Ts; Provisional; Region: tsf; PRK09377 568707001176 UBA/TS-N domain; Region: UBA; pfam00627 568707001177 Elongation factor TS; Region: EF_TS; pfam00889 568707001178 Elongation factor TS; Region: EF_TS; pfam00889 568707001179 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 568707001180 putative nucleotide binding site [chemical binding]; other site 568707001181 uridine monophosphate binding site [chemical binding]; other site 568707001182 homohexameric interface [polypeptide binding]; other site 568707001183 ribosome recycling factor; Reviewed; Region: frr; PRK00083 568707001184 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 568707001185 hinge region; other site 568707001186 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 568707001187 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 568707001188 catalytic residue [active] 568707001189 putative FPP diphosphate binding site; other site 568707001190 putative FPP binding hydrophobic cleft; other site 568707001191 dimer interface [polypeptide binding]; other site 568707001192 putative IPP diphosphate binding site; other site 568707001193 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 568707001194 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 568707001195 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 568707001196 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 568707001197 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 568707001198 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 568707001199 zinc metallopeptidase RseP; Provisional; Region: PRK10779 568707001200 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 568707001201 active site 568707001202 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 568707001203 putative substrate binding region [chemical binding]; other site 568707001204 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 568707001205 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568707001206 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568707001207 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568707001208 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568707001209 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 568707001210 Surface antigen; Region: Bac_surface_Ag; pfam01103 568707001211 periplasmic chaperone; Provisional; Region: PRK10780 568707001212 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 568707001213 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 568707001214 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 568707001215 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 568707001216 trimer interface [polypeptide binding]; other site 568707001217 active site 568707001218 UDP-GlcNAc binding site [chemical binding]; other site 568707001219 lipid binding site [chemical binding]; lipid-binding site 568707001220 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 568707001221 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 568707001222 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 568707001223 active site 568707001224 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 568707001225 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 568707001226 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 568707001227 RNA/DNA hybrid binding site [nucleotide binding]; other site 568707001228 active site 568707001229 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 568707001230 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568707001231 PEP synthetase regulatory protein; Provisional; Region: PRK05339 568707001232 phosphoenolpyruvate synthase; Validated; Region: PRK06464 568707001233 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 568707001234 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568707001235 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568707001236 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 568707001237 catalytic triad [active] 568707001238 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 568707001239 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 568707001240 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707001241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707001242 metal binding site [ion binding]; metal-binding site 568707001243 active site 568707001244 I-site; other site 568707001245 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 568707001246 SmpB-tmRNA interface; other site 568707001247 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 568707001248 putative coenzyme Q binding site [chemical binding]; other site 568707001249 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 568707001250 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707001251 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707001252 active site 568707001253 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 568707001254 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707001255 substrate binding site [chemical binding]; other site 568707001256 oxyanion hole (OAH) forming residues; other site 568707001257 trimer interface [polypeptide binding]; other site 568707001258 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 568707001259 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568707001260 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 568707001261 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568707001262 CoenzymeA binding site [chemical binding]; other site 568707001263 subunit interaction site [polypeptide binding]; other site 568707001264 PHB binding site; other site 568707001265 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 568707001266 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 568707001267 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 568707001268 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 568707001269 YceG-like family; Region: YceG; pfam02618 568707001270 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 568707001271 dimerization interface [polypeptide binding]; other site 568707001272 thymidylate kinase; Validated; Region: tmk; PRK00698 568707001273 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 568707001274 TMP-binding site; other site 568707001275 ATP-binding site [chemical binding]; other site 568707001276 DNA polymerase III subunit delta'; Validated; Region: PRK06964 568707001277 DNA polymerase III subunit delta'; Validated; Region: PRK08485 568707001278 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 568707001279 active site 568707001280 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 568707001281 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 568707001282 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 568707001283 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707001284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707001285 putative DNA binding site [nucleotide binding]; other site 568707001286 putative Zn2+ binding site [ion binding]; other site 568707001287 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707001288 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707001289 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568707001290 substrate binding pocket [chemical binding]; other site 568707001291 membrane-bound complex binding site; other site 568707001292 hinge residues; other site 568707001293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707001294 dimer interface [polypeptide binding]; other site 568707001295 conserved gate region; other site 568707001296 putative PBP binding loops; other site 568707001297 ABC-ATPase subunit interface; other site 568707001298 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568707001299 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568707001300 Walker A/P-loop; other site 568707001301 ATP binding site [chemical binding]; other site 568707001302 Q-loop/lid; other site 568707001303 ABC transporter signature motif; other site 568707001304 Walker B; other site 568707001305 D-loop; other site 568707001306 H-loop/switch region; other site 568707001307 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 568707001308 putative active site [active] 568707001309 putative metal binding site [ion binding]; other site 568707001310 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 568707001311 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 568707001312 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 568707001313 NAD(P) binding site [chemical binding]; other site 568707001314 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 568707001315 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 568707001316 NAD(P) binding site [chemical binding]; other site 568707001317 catalytic residues [active] 568707001318 allantoate amidohydrolase; Reviewed; Region: PRK12893 568707001319 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 568707001320 active site 568707001321 metal binding site [ion binding]; metal-binding site 568707001322 dimer interface [polypeptide binding]; other site 568707001323 thiamine pyrophosphate protein; Validated; Region: PRK08199 568707001324 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707001325 PYR/PP interface [polypeptide binding]; other site 568707001326 dimer interface [polypeptide binding]; other site 568707001327 TPP binding site [chemical binding]; other site 568707001328 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707001329 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 568707001330 TPP-binding site [chemical binding]; other site 568707001331 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 568707001332 DctM-like transporters; Region: DctM; pfam06808 568707001333 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568707001334 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 568707001335 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707001336 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 568707001337 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568707001338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707001339 DNA-binding site [nucleotide binding]; DNA binding site 568707001340 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568707001341 Protein of unknown function, DUF488; Region: DUF488; cl01246 568707001343 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 568707001344 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 568707001345 TrkA-C domain; Region: TrkA_C; pfam02080 568707001346 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 568707001347 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568707001348 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 568707001349 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568707001350 catalytic residue [active] 568707001351 Transmembrane secretion effector; Region: MFS_3; pfam05977 568707001352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707001353 putative substrate translocation pore; other site 568707001354 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707001355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707001356 metal binding site [ion binding]; metal-binding site 568707001357 active site 568707001358 I-site; other site 568707001359 RNA polymerase sigma factor; Provisional; Region: PRK12511 568707001360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707001361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568707001362 DNA binding residues [nucleotide binding] 568707001363 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 568707001364 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 568707001365 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 568707001366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707001367 active site 568707001368 phosphorylation site [posttranslational modification] 568707001369 intermolecular recognition site; other site 568707001370 dimerization interface [polypeptide binding]; other site 568707001371 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568707001372 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 568707001373 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568707001374 Ligand Binding Site [chemical binding]; other site 568707001375 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 568707001376 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily; Region: M14_ASTE_ASPA_like; cd06230 568707001377 active site 568707001378 Zn binding site [ion binding]; other site 568707001379 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 568707001380 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 568707001381 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 568707001382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568707001383 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 568707001384 Transporter associated domain; Region: CorC_HlyC; pfam03471 568707001385 Amino acid synthesis; Region: AA_synth; pfam06684 568707001386 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001387 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568707001388 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568707001389 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 568707001390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707001391 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 568707001392 putative dimerization interface [polypeptide binding]; other site 568707001393 hypothetical protein; Provisional; Region: PRK06486 568707001394 intersubunit interface [polypeptide binding]; other site 568707001395 active site 568707001396 Zn2+ binding site [ion binding]; other site 568707001397 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 568707001398 dimer interface [polypeptide binding]; other site 568707001399 catalytic triad [active] 568707001400 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 568707001401 Na binding site [ion binding]; other site 568707001402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707001403 putative substrate translocation pore; other site 568707001404 short chain dehydrogenase; Provisional; Region: PRK12747 568707001405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707001406 NAD(P) binding site [chemical binding]; other site 568707001407 active site 568707001408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707001409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707001410 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 568707001411 putative dimerization interface [polypeptide binding]; other site 568707001412 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 568707001413 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 568707001414 active site pocket [active] 568707001415 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001416 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 568707001417 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 568707001418 active site 568707001419 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 568707001420 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568707001421 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707001422 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707001423 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568707001424 carboxyltransferase (CT) interaction site; other site 568707001425 biotinylation site [posttranslational modification]; other site 568707001426 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 568707001427 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568707001428 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568707001429 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568707001430 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 568707001431 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 568707001432 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001434 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568707001435 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 568707001436 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568707001437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707001438 ABC-ATPase subunit interface; other site 568707001439 putative PBP binding loops; other site 568707001440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707001441 dimer interface [polypeptide binding]; other site 568707001442 conserved gate region; other site 568707001443 putative PBP binding loops; other site 568707001444 ABC-ATPase subunit interface; other site 568707001445 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 568707001446 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568707001447 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568707001448 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 568707001449 Walker A/P-loop; other site 568707001450 ATP binding site [chemical binding]; other site 568707001451 Q-loop/lid; other site 568707001452 ABC transporter signature motif; other site 568707001453 Walker B; other site 568707001454 D-loop; other site 568707001455 H-loop/switch region; other site 568707001456 TOBE domain; Region: TOBE_2; pfam08402 568707001457 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707001458 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707001459 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707001460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707001461 NAD(P) binding site [chemical binding]; other site 568707001462 active site 568707001463 Dienelactone hydrolase family; Region: DLH; pfam01738 568707001464 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707001465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707001466 DNA-binding site [nucleotide binding]; DNA binding site 568707001467 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568707001468 DctM-like transporters; Region: DctM; pfam06808 568707001469 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 568707001470 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707001471 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707001472 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707001473 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 568707001474 agmatinase; Region: agmatinase; TIGR01230 568707001475 oligomer interface [polypeptide binding]; other site 568707001476 putative active site [active] 568707001477 Mn binding site [ion binding]; other site 568707001478 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001479 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 568707001480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707001481 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707001482 dimerization interface [polypeptide binding]; other site 568707001483 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 568707001484 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 568707001485 ligand binding site [chemical binding]; other site 568707001486 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707001487 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 568707001488 TM-ABC transporter signature motif; other site 568707001489 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 568707001490 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 568707001491 Walker A/P-loop; other site 568707001492 ATP binding site [chemical binding]; other site 568707001493 Q-loop/lid; other site 568707001494 ABC transporter signature motif; other site 568707001495 Walker B; other site 568707001496 D-loop; other site 568707001497 H-loop/switch region; other site 568707001498 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 568707001499 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568707001500 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568707001501 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568707001502 homotrimer interaction site [polypeptide binding]; other site 568707001503 putative active site [active] 568707001504 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 568707001505 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568707001506 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 568707001507 active site 568707001508 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568707001509 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568707001510 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707001511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707001512 DNA-binding site [nucleotide binding]; DNA binding site 568707001513 FCD domain; Region: FCD; pfam07729 568707001514 HipA N-terminal domain; Region: Couple_hipA; pfam13657 568707001515 HipA-like N-terminal domain; Region: HipA_N; pfam07805 568707001516 HipA-like C-terminal domain; Region: HipA_C; pfam07804 568707001517 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568707001518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707001519 non-specific DNA binding site [nucleotide binding]; other site 568707001520 salt bridge; other site 568707001521 sequence-specific DNA binding site [nucleotide binding]; other site 568707001522 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568707001523 CoenzymeA binding site [chemical binding]; other site 568707001524 subunit interaction site [polypeptide binding]; other site 568707001525 PHB binding site; other site 568707001526 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 568707001527 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568707001528 classical (c) SDRs; Region: SDR_c; cd05233 568707001529 NAD(P) binding site [chemical binding]; other site 568707001530 active site 568707001531 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001532 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 568707001533 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 568707001534 Uncharacterized conserved protein [Function unknown]; Region: COG1262 568707001535 MoxR-like ATPases [General function prediction only]; Region: COG0714 568707001536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707001537 Walker A motif; other site 568707001538 ATP binding site [chemical binding]; other site 568707001539 Walker B motif; other site 568707001540 arginine finger; other site 568707001541 Protein of unknown function DUF58; Region: DUF58; pfam01882 568707001542 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 568707001543 metal ion-dependent adhesion site (MIDAS); other site 568707001544 von Willebrand factor type A domain; Region: VWA_2; pfam13519 568707001545 Oxygen tolerance; Region: BatD; pfam13584 568707001546 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 568707001547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707001548 motif II; other site 568707001549 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 568707001550 Sulfatase; Region: Sulfatase; pfam00884 568707001551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 568707001552 Histidine kinase; Region: HisKA_3; pfam07730 568707001553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707001554 ATP binding site [chemical binding]; other site 568707001555 Mg2+ binding site [ion binding]; other site 568707001556 G-X-G motif; other site 568707001557 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568707001558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707001559 active site 568707001560 phosphorylation site [posttranslational modification] 568707001561 intermolecular recognition site; other site 568707001562 dimerization interface [polypeptide binding]; other site 568707001563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707001564 DNA binding residues [nucleotide binding] 568707001565 dimerization interface [polypeptide binding]; other site 568707001566 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568707001567 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707001568 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707001569 non-specific DNA binding site [nucleotide binding]; other site 568707001570 salt bridge; other site 568707001571 sequence-specific DNA binding site [nucleotide binding]; other site 568707001572 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 568707001573 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 568707001574 glutathionine S-transferase; Provisional; Region: PRK10542 568707001575 C-terminal domain interface [polypeptide binding]; other site 568707001576 GSH binding site (G-site) [chemical binding]; other site 568707001577 dimer interface [polypeptide binding]; other site 568707001578 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 568707001579 dimer interface [polypeptide binding]; other site 568707001580 N-terminal domain interface [polypeptide binding]; other site 568707001581 substrate binding pocket (H-site) [chemical binding]; other site 568707001582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707001583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707001584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707001585 dimerization interface [polypeptide binding]; other site 568707001586 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001587 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 568707001588 Sulfatase; Region: Sulfatase; pfam00884 568707001589 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 568707001590 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707001591 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707001592 putative DNA binding site [nucleotide binding]; other site 568707001593 putative Zn2+ binding site [ion binding]; other site 568707001594 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707001595 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707001596 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707001597 lipid-transfer protein; Provisional; Region: PRK08256 568707001598 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 568707001599 active site 568707001600 DUF35 OB-fold domain; Region: DUF35; pfam01796 568707001601 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001602 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568707001603 classical (c) SDRs; Region: SDR_c; cd05233 568707001604 NAD(P) binding site [chemical binding]; other site 568707001605 active site 568707001606 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 568707001607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707001608 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 568707001609 putative dimerization interface [polypeptide binding]; other site 568707001610 putative substrate binding pocket [chemical binding]; other site 568707001611 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001612 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707001613 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707001614 enoyl-CoA hydratase; Provisional; Region: PRK06494 568707001615 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707001616 substrate binding site [chemical binding]; other site 568707001617 oxyanion hole (OAH) forming residues; other site 568707001618 trimer interface [polypeptide binding]; other site 568707001619 enoyl-CoA hydratase; Provisional; Region: PRK09245 568707001620 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707001621 substrate binding site [chemical binding]; other site 568707001622 oxyanion hole (OAH) forming residues; other site 568707001623 trimer interface [polypeptide binding]; other site 568707001624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707001625 enoyl-CoA hydratase; Provisional; Region: PRK09076 568707001626 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707001627 substrate binding site [chemical binding]; other site 568707001628 oxyanion hole (OAH) forming residues; other site 568707001629 trimer interface [polypeptide binding]; other site 568707001630 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 568707001631 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568707001632 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568707001633 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568707001634 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 568707001635 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568707001636 dimer interface [polypeptide binding]; other site 568707001637 active site 568707001638 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 568707001639 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 568707001640 putative active site [active] 568707001641 metal binding site [ion binding]; metal-binding site 568707001642 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 568707001643 active site 568707001644 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 568707001645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568707001646 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568707001647 salicylate hydroxylase; Provisional; Region: PRK08163 568707001648 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568707001649 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707001651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707001652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707001653 dimerization interface [polypeptide binding]; other site 568707001654 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 568707001655 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568707001656 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 568707001657 ArsC family; Region: ArsC; pfam03960 568707001658 catalytic residues [active] 568707001659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707001660 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707001661 putative DNA binding site [nucleotide binding]; other site 568707001662 putative Zn2+ binding site [ion binding]; other site 568707001663 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 568707001664 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 568707001665 active site 568707001666 putative substrate binding pocket [chemical binding]; other site 568707001667 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568707001668 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001669 dihydropteridine reductase (DHPR), classical (c) SDRs; Region: DHPR_SDR_c_like; cd05334 568707001670 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 568707001671 NAD binding site [chemical binding]; other site 568707001672 homodimer interface [polypeptide binding]; other site 568707001673 active site 568707001674 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707001675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707001676 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707001677 dimerization interface [polypeptide binding]; other site 568707001678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568707001679 PAS fold; Region: PAS_3; pfam08447 568707001680 putative active site [active] 568707001681 heme pocket [chemical binding]; other site 568707001682 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707001683 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707001684 metal binding site [ion binding]; metal-binding site 568707001685 active site 568707001686 I-site; other site 568707001687 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 568707001688 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 568707001689 active site 568707001690 dimer interface [polypeptide binding]; other site 568707001691 metal binding site [ion binding]; metal-binding site 568707001692 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 568707001693 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 568707001694 dimer interface [polypeptide binding]; other site 568707001695 active site residues [active] 568707001696 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 568707001697 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 568707001698 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 568707001699 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568707001700 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568707001701 Walker A/P-loop; other site 568707001702 ATP binding site [chemical binding]; other site 568707001703 Q-loop/lid; other site 568707001704 ABC transporter signature motif; other site 568707001705 Walker B; other site 568707001706 D-loop; other site 568707001707 H-loop/switch region; other site 568707001708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707001709 dimer interface [polypeptide binding]; other site 568707001710 conserved gate region; other site 568707001711 putative PBP binding loops; other site 568707001712 ABC-ATPase subunit interface; other site 568707001713 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568707001714 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707001715 substrate binding pocket [chemical binding]; other site 568707001716 membrane-bound complex binding site; other site 568707001717 hinge residues; other site 568707001718 periplasmic nitrate reductase, NapE protein; Region: nitrate_rd_NapE; TIGR02973 568707001719 NapD protein; Region: NapD; pfam03927 568707001720 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 568707001721 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 568707001722 [4Fe-4S] binding site [ion binding]; other site 568707001723 molybdopterin cofactor binding site; other site 568707001724 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 568707001725 molybdopterin cofactor binding site; other site 568707001726 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 568707001727 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 568707001728 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 568707001729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707001730 Walker A/P-loop; other site 568707001731 ATP binding site [chemical binding]; other site 568707001732 ABC transporter; Region: ABC_tran; pfam00005 568707001733 Q-loop/lid; other site 568707001734 ABC transporter signature motif; other site 568707001735 Walker B; other site 568707001736 D-loop; other site 568707001737 CcmB protein; Region: CcmB; cl17444 568707001738 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 568707001739 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 568707001740 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 568707001741 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 568707001742 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 568707001743 catalytic residues [active] 568707001744 central insert; other site 568707001745 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 568707001746 TPR motif; other site 568707001747 Tetratricopeptide repeat; Region: TPR_8; pfam13181 568707001748 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 568707001749 dimer interface [polypeptide binding]; other site 568707001750 putative inhibitory loop; other site 568707001751 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568707001752 homotrimer interaction site [polypeptide binding]; other site 568707001753 putative active site [active] 568707001754 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 568707001755 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 568707001756 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 568707001757 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 568707001758 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 568707001759 putative active site pocket [active] 568707001760 metal binding site [ion binding]; metal-binding site 568707001761 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001762 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 568707001763 substrate binding site [chemical binding]; other site 568707001764 ligand binding site [chemical binding]; other site 568707001765 3-isopropylmalate dehydratase, small subunit; Region: leuD; TIGR00171 568707001766 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 568707001767 substrate binding site [chemical binding]; other site 568707001768 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568707001769 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568707001770 DNA binding site [nucleotide binding] 568707001771 domain linker motif; other site 568707001772 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 568707001773 dimerization interface [polypeptide binding]; other site 568707001774 ligand binding site [chemical binding]; other site 568707001775 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001776 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707001777 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707001778 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 568707001779 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 568707001780 active site 568707001781 citrylCoA binding site [chemical binding]; other site 568707001782 oxalacetate binding site [chemical binding]; other site 568707001783 coenzyme A binding site [chemical binding]; other site 568707001784 catalytic triad [active] 568707001785 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707001786 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 568707001787 CoA binding domain; Region: CoA_binding_2; pfam13380 568707001788 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 568707001789 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 568707001790 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707001791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707001792 DNA-binding site [nucleotide binding]; DNA binding site 568707001793 FCD domain; Region: FCD; pfam07729 568707001794 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 568707001795 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568707001796 Predicted flavoprotein [General function prediction only]; Region: COG0431 568707001797 LysR family transcriptional regulator; Provisional; Region: PRK14997 568707001798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707001799 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 568707001800 putative effector binding pocket; other site 568707001801 putative dimerization interface [polypeptide binding]; other site 568707001802 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 568707001803 RNase_H superfamily; Region: RNase_H_2; pfam13482 568707001804 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 568707001805 AAA domain; Region: AAA_12; pfam13087 568707001806 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 568707001807 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568707001808 Autotransporter beta-domain; Region: Autotransporter; smart00869 568707001809 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 568707001810 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 568707001811 FAD binding pocket [chemical binding]; other site 568707001812 FAD binding motif [chemical binding]; other site 568707001813 phosphate binding motif [ion binding]; other site 568707001814 NAD binding pocket [chemical binding]; other site 568707001815 Predicted transcriptional regulators [Transcription]; Region: COG1695 568707001816 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 568707001817 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 568707001818 putative catalytic site [active] 568707001819 putative metal binding site [ion binding]; other site 568707001820 putative phosphate binding site [ion binding]; other site 568707001821 cardiolipin synthase 2; Provisional; Region: PRK11263 568707001822 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 568707001823 putative active site [active] 568707001824 catalytic site [active] 568707001825 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 568707001826 putative active site [active] 568707001827 catalytic site [active] 568707001828 Predicted integral membrane protein [Function unknown]; Region: COG0392 568707001829 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 568707001830 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 568707001831 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568707001832 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 568707001833 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 568707001834 active site 568707001835 DNA binding site [nucleotide binding] 568707001836 Int/Topo IB signature motif; other site 568707001837 catalytic residues [active] 568707001838 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 568707001839 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 568707001840 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 568707001841 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 568707001842 putative DNA binding site [nucleotide binding]; other site 568707001843 putative homodimer interface [polypeptide binding]; other site 568707001844 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 568707001845 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 568707001846 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 568707001847 active site 568707001848 DNA binding site [nucleotide binding] 568707001849 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 568707001850 DNA binding site [nucleotide binding] 568707001851 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 568707001852 nucleotide binding site [chemical binding]; other site 568707001853 short chain dehydrogenase; Provisional; Region: PRK06701 568707001854 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 568707001855 NAD binding site [chemical binding]; other site 568707001856 metal binding site [ion binding]; metal-binding site 568707001857 active site 568707001858 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 568707001859 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 568707001860 Predicted membrane protein [Function unknown]; Region: COG2323 568707001861 PRC-barrel domain; Region: PRC; pfam05239 568707001862 BON domain; Region: BON; pfam04972 568707001863 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 568707001864 thiamine pyrophosphate protein; Provisional; Region: PRK08273 568707001865 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 568707001866 PYR/PP interface [polypeptide binding]; other site 568707001867 dimer interface [polypeptide binding]; other site 568707001868 tetramer interface [polypeptide binding]; other site 568707001869 TPP binding site [chemical binding]; other site 568707001870 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707001871 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 568707001872 TPP-binding site [chemical binding]; other site 568707001873 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 568707001874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707001875 active site 568707001876 phosphorylation site [posttranslational modification] 568707001877 intermolecular recognition site; other site 568707001878 dimerization interface [polypeptide binding]; other site 568707001879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707001880 Walker A motif; other site 568707001881 ATP binding site [chemical binding]; other site 568707001882 Walker B motif; other site 568707001883 arginine finger; other site 568707001884 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568707001885 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 568707001886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707001887 Walker A motif; other site 568707001888 ATP binding site [chemical binding]; other site 568707001889 Walker B motif; other site 568707001890 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 568707001891 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 568707001892 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 568707001893 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 568707001894 glycogen synthase; Provisional; Region: glgA; PRK00654 568707001895 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 568707001896 ADP-binding pocket [chemical binding]; other site 568707001897 homodimer interface [polypeptide binding]; other site 568707001898 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 568707001899 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 568707001900 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 568707001901 active site 568707001902 homodimer interface [polypeptide binding]; other site 568707001903 catalytic site [active] 568707001904 acceptor binding site [chemical binding]; other site 568707001905 trehalose synthase; Region: treS_nterm; TIGR02456 568707001906 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 568707001907 active site 568707001908 catalytic site [active] 568707001909 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 568707001910 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 568707001911 glycogen branching enzyme; Provisional; Region: PRK05402 568707001912 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 568707001913 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 568707001914 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 568707001915 active site 568707001916 catalytic site [active] 568707001917 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 568707001918 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 568707001919 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 568707001920 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 568707001921 active site 568707001922 catalytic site [active] 568707001923 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 568707001924 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 568707001925 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 568707001926 catalytic site [active] 568707001927 active site 568707001928 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 568707001929 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 568707001930 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 568707001931 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 568707001932 active site 568707001933 catalytic site [active] 568707001934 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 568707001935 GAF domain; Region: GAF; pfam01590 568707001936 GAF domain; Region: GAF_3; pfam13492 568707001937 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 568707001938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568707001939 putative active site [active] 568707001940 heme pocket [chemical binding]; other site 568707001941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707001942 dimer interface [polypeptide binding]; other site 568707001943 phosphorylation site [posttranslational modification] 568707001944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707001945 ATP binding site [chemical binding]; other site 568707001946 Mg2+ binding site [ion binding]; other site 568707001947 G-X-G motif; other site 568707001948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707001949 Response regulator receiver domain; Region: Response_reg; pfam00072 568707001950 active site 568707001951 phosphorylation site [posttranslational modification] 568707001952 intermolecular recognition site; other site 568707001953 dimerization interface [polypeptide binding]; other site 568707001954 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 568707001955 dimer interface [polypeptide binding]; other site 568707001956 pyridoxamine kinase; Validated; Region: PRK05756 568707001957 pyridoxal binding site [chemical binding]; other site 568707001958 ATP binding site [chemical binding]; other site 568707001959 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 568707001960 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568707001961 catalytic residue [active] 568707001962 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 568707001963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707001964 DNA-binding site [nucleotide binding]; DNA binding site 568707001965 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707001966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707001967 homodimer interface [polypeptide binding]; other site 568707001968 catalytic residue [active] 568707001969 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568707001970 Ligand Binding Site [chemical binding]; other site 568707001971 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568707001972 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568707001973 active site 568707001974 catalytic tetrad [active] 568707001976 DoxX; Region: DoxX; pfam07681 568707001977 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 568707001978 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 568707001979 catalytic triad [active] 568707001980 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 568707001981 ArsC family; Region: ArsC; pfam03960 568707001982 catalytic residues [active] 568707001983 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707001984 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707001985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568707001986 TPR repeat; Region: TPR_11; pfam13414 568707001987 binding surface 568707001988 TPR motif; other site 568707001989 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 568707001990 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 568707001991 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 568707001992 catalytic residues [active] 568707001993 dimer interface [polypeptide binding]; other site 568707001994 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 568707001995 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 568707001996 C-terminal domain interface [polypeptide binding]; other site 568707001997 GSH binding site (G-site) [chemical binding]; other site 568707001998 dimer interface [polypeptide binding]; other site 568707001999 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 568707002000 N-terminal domain interface [polypeptide binding]; other site 568707002001 putative dimer interface [polypeptide binding]; other site 568707002002 active site 568707002003 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568707002004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707002005 Coenzyme A binding pocket [chemical binding]; other site 568707002006 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 568707002007 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 568707002008 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 568707002009 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 568707002010 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 568707002011 phosphate binding site [ion binding]; other site 568707002012 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568707002013 RES domain; Region: RES; pfam08808 568707002014 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 568707002015 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 568707002016 Protein of unknown function (DUF423); Region: DUF423; pfam04241 568707002017 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568707002018 EamA-like transporter family; Region: EamA; pfam00892 568707002019 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 568707002020 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 568707002021 C-terminal domain interface [polypeptide binding]; other site 568707002022 GSH binding site (G-site) [chemical binding]; other site 568707002023 dimer interface [polypeptide binding]; other site 568707002024 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 568707002025 dimer interface [polypeptide binding]; other site 568707002026 N-terminal domain interface [polypeptide binding]; other site 568707002027 substrate binding pocket (H-site) [chemical binding]; other site 568707002028 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 568707002029 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 568707002030 glutathionine S-transferase; Provisional; Region: PRK10542 568707002031 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 568707002032 C-terminal domain interface [polypeptide binding]; other site 568707002033 GSH binding site (G-site) [chemical binding]; other site 568707002034 dimer interface [polypeptide binding]; other site 568707002035 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 568707002036 dimer interface [polypeptide binding]; other site 568707002037 N-terminal domain interface [polypeptide binding]; other site 568707002038 substrate binding pocket (H-site) [chemical binding]; other site 568707002039 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 568707002040 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707002041 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707002042 Walker A/P-loop; other site 568707002043 ATP binding site [chemical binding]; other site 568707002044 Q-loop/lid; other site 568707002045 ABC transporter signature motif; other site 568707002046 Walker B; other site 568707002047 D-loop; other site 568707002048 H-loop/switch region; other site 568707002049 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 568707002050 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707002051 Walker A/P-loop; other site 568707002052 ATP binding site [chemical binding]; other site 568707002053 Q-loop/lid; other site 568707002054 ABC transporter signature motif; other site 568707002055 Walker B; other site 568707002056 D-loop; other site 568707002057 H-loop/switch region; other site 568707002058 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 568707002059 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707002060 TM-ABC transporter signature motif; other site 568707002061 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707002062 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707002063 TM-ABC transporter signature motif; other site 568707002064 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568707002065 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 568707002066 dimerization interface [polypeptide binding]; other site 568707002067 ligand binding site [chemical binding]; other site 568707002068 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 568707002069 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 568707002070 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 568707002071 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568707002072 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568707002073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707002074 dimer interface [polypeptide binding]; other site 568707002075 conserved gate region; other site 568707002076 putative PBP binding loops; other site 568707002077 ABC-ATPase subunit interface; other site 568707002078 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568707002079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707002080 dimer interface [polypeptide binding]; other site 568707002081 conserved gate region; other site 568707002082 putative PBP binding loops; other site 568707002083 ABC-ATPase subunit interface; other site 568707002084 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 568707002085 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 568707002086 Walker A/P-loop; other site 568707002087 ATP binding site [chemical binding]; other site 568707002088 Q-loop/lid; other site 568707002089 ABC transporter signature motif; other site 568707002090 Walker B; other site 568707002091 D-loop; other site 568707002092 H-loop/switch region; other site 568707002093 TOBE domain; Region: TOBE_2; pfam08402 568707002094 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568707002095 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 568707002096 dimerization interface [polypeptide binding]; other site 568707002097 ligand binding site [chemical binding]; other site 568707002098 Serine hydrolase; Region: Ser_hydrolase; pfam06821 568707002099 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568707002100 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 568707002101 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 568707002102 active site 568707002103 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 568707002104 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 568707002105 Methyltransferase domain; Region: Methyltransf_12; pfam08242 568707002106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707002107 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 568707002108 Enoylreductase; Region: PKS_ER; smart00829 568707002109 NAD(P) binding site [chemical binding]; other site 568707002110 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 568707002111 KR domain; Region: KR; pfam08659 568707002112 putative NADP binding site [chemical binding]; other site 568707002113 active site 568707002114 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 568707002115 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 568707002116 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 568707002117 substrate-cofactor binding pocket; other site 568707002118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707002119 catalytic residue [active] 568707002120 Sulfatase; Region: Sulfatase; cl17466 568707002121 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 568707002122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707002123 NAD(P) binding site [chemical binding]; other site 568707002124 active site 568707002125 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 568707002126 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 568707002127 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 568707002128 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 568707002129 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 568707002130 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 568707002131 NAD binding site [chemical binding]; other site 568707002132 substrate binding site [chemical binding]; other site 568707002133 homodimer interface [polypeptide binding]; other site 568707002134 active site 568707002135 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 568707002136 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 568707002137 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 568707002138 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 568707002139 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 568707002140 Vi polysaccharide biosynthesis protein TviD; Provisional; Region: PRK15180 568707002141 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15179 568707002142 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568707002143 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 568707002144 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 568707002145 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 568707002146 Walker A/P-loop; other site 568707002147 ATP binding site [chemical binding]; other site 568707002148 Q-loop/lid; other site 568707002149 ABC transporter signature motif; other site 568707002150 Walker B; other site 568707002151 D-loop; other site 568707002152 H-loop/switch region; other site 568707002153 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 568707002154 ABC-2 type transporter; Region: ABC2_membrane; cl17235 568707002155 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568707002156 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568707002157 active site 568707002158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568707002159 TPR motif; other site 568707002160 binding surface 568707002161 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 568707002162 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 568707002163 dimerization interface [polypeptide binding]; other site 568707002164 DPS ferroxidase diiron center [ion binding]; other site 568707002165 ion pore; other site 568707002166 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 568707002167 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 568707002168 tetrameric interface [polypeptide binding]; other site 568707002169 NAD binding site [chemical binding]; other site 568707002170 catalytic residues [active] 568707002171 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707002172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707002173 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568707002174 putative effector binding pocket; other site 568707002175 dimerization interface [polypeptide binding]; other site 568707002176 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 568707002177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707002178 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 568707002179 dimerization interface [polypeptide binding]; other site 568707002180 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 568707002181 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 568707002182 generic binding surface II; other site 568707002183 ssDNA binding site; other site 568707002184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568707002185 ATP binding site [chemical binding]; other site 568707002186 putative Mg++ binding site [ion binding]; other site 568707002187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568707002188 nucleotide binding region [chemical binding]; other site 568707002189 ATP-binding site [chemical binding]; other site 568707002190 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568707002191 homotrimer interaction site [polypeptide binding]; other site 568707002192 putative active site [active] 568707002194 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568707002195 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568707002196 active site 568707002197 catalytic tetrad [active] 568707002198 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 568707002199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707002200 putative substrate translocation pore; other site 568707002201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707002202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707002203 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 568707002204 putative effector binding pocket; other site 568707002205 dimerization interface [polypeptide binding]; other site 568707002206 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 568707002207 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 568707002208 FAD binding pocket [chemical binding]; other site 568707002209 FAD binding motif [chemical binding]; other site 568707002210 phosphate binding motif [ion binding]; other site 568707002211 beta-alpha-beta structure motif; other site 568707002212 NAD binding pocket [chemical binding]; other site 568707002213 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 568707002214 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568707002215 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 568707002216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707002217 dimer interface [polypeptide binding]; other site 568707002218 conserved gate region; other site 568707002219 putative PBP binding loops; other site 568707002220 ABC-ATPase subunit interface; other site 568707002221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707002222 dimer interface [polypeptide binding]; other site 568707002223 conserved gate region; other site 568707002224 ABC-ATPase subunit interface; other site 568707002225 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 568707002226 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 568707002227 Walker A/P-loop; other site 568707002228 ATP binding site [chemical binding]; other site 568707002229 Q-loop/lid; other site 568707002230 ABC transporter signature motif; other site 568707002231 Walker B; other site 568707002232 D-loop; other site 568707002233 H-loop/switch region; other site 568707002234 Pirin-related protein [General function prediction only]; Region: COG1741 568707002235 Pirin; Region: Pirin; pfam02678 568707002236 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 568707002237 Pirin-related protein [General function prediction only]; Region: COG1741 568707002238 Pirin; Region: Pirin; pfam02678 568707002239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707002240 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 568707002241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707002242 dimerization interface [polypeptide binding]; other site 568707002243 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 568707002244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707002245 active site 568707002246 phosphorylation site [posttranslational modification] 568707002247 intermolecular recognition site; other site 568707002248 dimerization interface [polypeptide binding]; other site 568707002249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707002250 Walker A motif; other site 568707002251 ATP binding site [chemical binding]; other site 568707002252 Walker B motif; other site 568707002253 arginine finger; other site 568707002254 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568707002255 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 568707002256 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568707002257 putative active site [active] 568707002258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707002259 dimer interface [polypeptide binding]; other site 568707002260 phosphorylation site [posttranslational modification] 568707002261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707002262 ATP binding site [chemical binding]; other site 568707002263 Mg2+ binding site [ion binding]; other site 568707002264 G-X-G motif; other site 568707002265 glutamine synthetase; Provisional; Region: glnA; PRK09469 568707002266 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 568707002267 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 568707002268 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 568707002269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568707002270 FeS/SAM binding site; other site 568707002271 HemN C-terminal domain; Region: HemN_C; pfam06969 568707002272 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 568707002273 active site 568707002274 dimerization interface [polypeptide binding]; other site 568707002275 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568707002276 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 568707002277 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707002278 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707002279 metal binding site [ion binding]; metal-binding site 568707002280 active site 568707002281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707002282 dimerization interface [polypeptide binding]; other site 568707002283 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568707002284 dimer interface [polypeptide binding]; other site 568707002285 putative CheW interface [polypeptide binding]; other site 568707002286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707002287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707002288 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 568707002289 putative dimerization interface [polypeptide binding]; other site 568707002290 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 568707002291 ribonuclease PH; Reviewed; Region: rph; PRK00173 568707002292 Ribonuclease PH; Region: RNase_PH_bact; cd11362 568707002293 hexamer interface [polypeptide binding]; other site 568707002294 active site 568707002295 hypothetical protein; Provisional; Region: PRK11820 568707002296 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 568707002297 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 568707002298 allantoate amidohydrolase; Reviewed; Region: PRK12892 568707002299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707002300 non-specific DNA binding site [nucleotide binding]; other site 568707002301 salt bridge; other site 568707002302 sequence-specific DNA binding site [nucleotide binding]; other site 568707002303 AMP nucleosidase; Provisional; Region: PRK08292 568707002304 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 568707002305 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 568707002306 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 568707002307 NlpC/P60 family; Region: NLPC_P60; pfam00877 568707002308 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 568707002309 classical (c) SDRs; Region: SDR_c; cd05233 568707002310 NAD(P) binding site [chemical binding]; other site 568707002311 active site 568707002312 Cytochrome c; Region: Cytochrom_C; cl11414 568707002313 Cytochrome c; Region: Cytochrom_C; cl11414 568707002314 Cytochrome c [Energy production and conversion]; Region: COG3258 568707002315 Cytochrome c; Region: Cytochrom_C; pfam00034 568707002316 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 568707002317 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 568707002318 catalytic site [active] 568707002319 G-X2-G-X-G-K; other site 568707002320 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 568707002321 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 568707002322 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568707002323 Zn2+ binding site [ion binding]; other site 568707002324 Mg2+ binding site [ion binding]; other site 568707002325 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 568707002326 synthetase active site [active] 568707002327 NTP binding site [chemical binding]; other site 568707002328 metal binding site [ion binding]; metal-binding site 568707002329 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 568707002330 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 568707002331 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 568707002332 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568707002333 Walker A/P-loop; other site 568707002334 ATP binding site [chemical binding]; other site 568707002335 Q-loop/lid; other site 568707002336 ABC transporter signature motif; other site 568707002337 Walker B; other site 568707002338 D-loop; other site 568707002339 H-loop/switch region; other site 568707002340 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568707002341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707002342 dimer interface [polypeptide binding]; other site 568707002343 conserved gate region; other site 568707002344 putative PBP binding loops; other site 568707002345 ABC-ATPase subunit interface; other site 568707002346 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 568707002347 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707002348 substrate binding pocket [chemical binding]; other site 568707002349 membrane-bound complex binding site; other site 568707002350 hinge residues; other site 568707002351 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 568707002352 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 568707002353 5-oxoprolinase; Region: PLN02666 568707002354 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 568707002355 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 568707002356 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 568707002357 MarR family; Region: MarR_2; cl17246 568707002358 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707002359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707002360 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707002361 dimerization interface [polypeptide binding]; other site 568707002362 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707002363 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707002364 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 568707002365 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707002366 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707002367 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707002368 DctM-like transporters; Region: DctM; pfam06808 568707002369 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 568707002370 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 568707002371 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 568707002372 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 568707002373 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 568707002374 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 568707002375 PapC N-terminal domain; Region: PapC_N; pfam13954 568707002376 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568707002377 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 568707002378 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 568707002379 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 568707002380 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 568707002381 haemagglutination activity domain; Region: Haemagg_act; pfam05860 568707002382 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 568707002383 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 568707002384 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568707002385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707002386 active site 568707002387 phosphorylation site [posttranslational modification] 568707002388 intermolecular recognition site; other site 568707002389 dimerization interface [polypeptide binding]; other site 568707002390 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707002391 DNA binding residues [nucleotide binding] 568707002392 dimerization interface [polypeptide binding]; other site 568707002393 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 568707002394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707002395 substrate binding pocket [chemical binding]; other site 568707002396 membrane-bound complex binding site; other site 568707002397 hinge residues; other site 568707002398 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707002399 substrate binding pocket [chemical binding]; other site 568707002400 membrane-bound complex binding site; other site 568707002401 hinge residues; other site 568707002402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568707002403 putative active site [active] 568707002404 heme pocket [chemical binding]; other site 568707002405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707002406 dimer interface [polypeptide binding]; other site 568707002407 phosphorylation site [posttranslational modification] 568707002408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707002409 ATP binding site [chemical binding]; other site 568707002410 Mg2+ binding site [ion binding]; other site 568707002411 G-X-G motif; other site 568707002412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707002413 active site 568707002414 phosphorylation site [posttranslational modification] 568707002415 intermolecular recognition site; other site 568707002416 dimerization interface [polypeptide binding]; other site 568707002417 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 568707002418 putative binding surface; other site 568707002419 active site 568707002420 EAL domain; Region: EAL; pfam00563 568707002421 hypothetical protein; Provisional; Region: PRK05463 568707002422 amidase; Provisional; Region: PRK07056 568707002423 Amidase; Region: Amidase; cl11426 568707002424 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 568707002425 DctM-like transporters; Region: DctM; pfam06808 568707002426 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568707002427 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707002428 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707002429 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707002430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707002431 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707002432 dimerization interface [polypeptide binding]; other site 568707002433 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568707002434 EamA-like transporter family; Region: EamA; pfam00892 568707002435 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 568707002436 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 568707002437 Walker A/P-loop; other site 568707002438 ATP binding site [chemical binding]; other site 568707002439 Q-loop/lid; other site 568707002440 ABC transporter signature motif; other site 568707002441 Walker B; other site 568707002442 D-loop; other site 568707002443 H-loop/switch region; other site 568707002444 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 568707002445 active site 568707002446 catalytic triad [active] 568707002447 oxyanion hole [active] 568707002448 switch loop; other site 568707002449 SurA N-terminal domain; Region: SurA_N_3; cl07813 568707002450 periplasmic folding chaperone; Provisional; Region: PRK10788 568707002451 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568707002452 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 568707002453 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 568707002454 putative active site [active] 568707002455 catalytic site [active] 568707002456 putative metal binding site [ion binding]; other site 568707002457 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 568707002458 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 568707002459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568707002460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707002461 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568707002462 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 568707002463 catalytic triad [active] 568707002464 dimer interface [polypeptide binding]; other site 568707002465 Glutaredoxin-family domain; Region: GlrX-dom; TIGR02190 568707002466 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 568707002467 metal-binding site [ion binding] 568707002468 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 568707002469 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 568707002470 DNA binding residues [nucleotide binding] 568707002471 dimer interface [polypeptide binding]; other site 568707002472 copper binding site [ion binding]; other site 568707002473 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 568707002474 TRAM domain; Region: TRAM; cl01282 568707002475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707002476 S-adenosylmethionine binding site [chemical binding]; other site 568707002477 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 568707002478 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 568707002479 active site 568707002480 catalytic site [active] 568707002481 substrate binding site [chemical binding]; other site 568707002482 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 568707002483 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568707002484 Peptidase family M23; Region: Peptidase_M23; pfam01551 568707002485 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 568707002486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707002487 S-adenosylmethionine binding site [chemical binding]; other site 568707002488 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 568707002489 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 568707002490 UGMP family protein; Validated; Region: PRK09604 568707002491 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 568707002492 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 568707002493 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 568707002494 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 568707002495 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568707002496 catalytic residues [active] 568707002497 Uncharacterized conserved protein [Function unknown]; Region: COG1739 568707002498 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 568707002499 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 568707002500 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 568707002501 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707002502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707002503 dimer interface [polypeptide binding]; other site 568707002504 conserved gate region; other site 568707002505 putative PBP binding loops; other site 568707002506 ABC-ATPase subunit interface; other site 568707002507 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568707002508 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568707002509 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707002510 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707002511 Walker A/P-loop; other site 568707002512 ATP binding site [chemical binding]; other site 568707002513 Q-loop/lid; other site 568707002514 ABC transporter signature motif; other site 568707002515 Walker B; other site 568707002516 D-loop; other site 568707002517 H-loop/switch region; other site 568707002518 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 568707002519 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568707002520 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568707002521 ABC transporter; Region: ABC_tran_2; pfam12848 568707002522 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568707002523 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 568707002524 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707002525 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 568707002526 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 568707002527 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 568707002528 enoyl-CoA hydratase; Provisional; Region: PRK05995 568707002529 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707002530 substrate binding site [chemical binding]; other site 568707002531 oxyanion hole (OAH) forming residues; other site 568707002532 trimer interface [polypeptide binding]; other site 568707002533 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 568707002534 dimer interface [polypeptide binding]; other site 568707002535 catalytic triad [active] 568707002536 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 568707002537 nucleoside/Zn binding site; other site 568707002538 dimer interface [polypeptide binding]; other site 568707002539 catalytic motif [active] 568707002540 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 568707002541 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 568707002542 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 568707002543 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 568707002544 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 568707002545 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568707002546 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 568707002547 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 568707002548 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568707002549 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 568707002550 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 568707002551 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707002552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707002553 AAA domain; Region: AAA_23; pfam13476 568707002554 Walker A/P-loop; other site 568707002555 ATP binding site [chemical binding]; other site 568707002556 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 568707002557 active site 568707002558 metal binding site [ion binding]; metal-binding site 568707002559 DNA binding site [nucleotide binding] 568707002560 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568707002561 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 568707002562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707002563 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568707002564 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 568707002565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707002566 putative DNA binding site [nucleotide binding]; other site 568707002567 putative Zn2+ binding site [ion binding]; other site 568707002568 AsnC family; Region: AsnC_trans_reg; pfam01037 568707002569 Protein of unknown function (DUF502); Region: DUF502; pfam04367 568707002570 transglutaminase; Provisional; Region: tgl; PRK03187 568707002571 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568707002572 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 568707002573 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568707002574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707002575 dimer interface [polypeptide binding]; other site 568707002576 conserved gate region; other site 568707002577 putative PBP binding loops; other site 568707002578 ABC-ATPase subunit interface; other site 568707002579 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568707002580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707002581 putative PBP binding loops; other site 568707002582 dimer interface [polypeptide binding]; other site 568707002583 ABC-ATPase subunit interface; other site 568707002584 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 568707002585 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 568707002586 Walker A/P-loop; other site 568707002587 ATP binding site [chemical binding]; other site 568707002588 Q-loop/lid; other site 568707002589 ABC transporter signature motif; other site 568707002590 Walker B; other site 568707002591 D-loop; other site 568707002592 H-loop/switch region; other site 568707002593 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 568707002594 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 568707002595 Walker A/P-loop; other site 568707002596 ATP binding site [chemical binding]; other site 568707002597 Q-loop/lid; other site 568707002598 ABC transporter signature motif; other site 568707002599 Walker B; other site 568707002600 D-loop; other site 568707002601 H-loop/switch region; other site 568707002602 TOBE domain; Region: TOBE_2; pfam08402 568707002603 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 568707002604 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 568707002605 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 568707002606 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 568707002607 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707002608 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707002609 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707002610 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 568707002611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707002612 NAD(P) binding site [chemical binding]; other site 568707002613 active site 568707002614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707002615 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 568707002616 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 568707002617 L-aspartate oxidase; Provisional; Region: PRK06175 568707002618 Predicted oxidoreductase [General function prediction only]; Region: COG3573 568707002619 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 568707002620 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 568707002621 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 568707002622 potential catalytic triad [active] 568707002623 conserved cys residue [active] 568707002624 NRDE protein; Region: NRDE; cl01315 568707002625 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 568707002626 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707002627 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 568707002628 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 568707002629 inhibitor site; inhibition site 568707002630 active site 568707002631 dimer interface [polypeptide binding]; other site 568707002632 catalytic residue [active] 568707002633 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707002634 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707002635 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707002636 MAPEG family; Region: MAPEG; cl09190 568707002637 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 568707002638 hypothetical protein; Provisional; Region: PRK09256 568707002639 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 568707002640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568707002641 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 568707002642 active site 568707002643 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707002644 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707002645 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 568707002646 intersubunit interface [polypeptide binding]; other site 568707002647 active site 568707002648 Zn2+ binding site [ion binding]; other site 568707002649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707002650 non-specific DNA binding site [nucleotide binding]; other site 568707002651 salt bridge; other site 568707002652 sequence-specific DNA binding site [nucleotide binding]; other site 568707002653 Cupin domain; Region: Cupin_2; pfam07883 568707002654 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568707002655 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 568707002656 Fusaric acid resistance protein family; Region: FUSC; pfam04632 568707002657 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 568707002658 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 568707002659 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 568707002660 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568707002661 HlyD family secretion protein; Region: HlyD_3; pfam13437 568707002662 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 568707002663 Predicted esterase [General function prediction only]; Region: COG0400 568707002664 putative hydrolase; Provisional; Region: PRK11460 568707002665 Uncharacterized conserved protein [Function unknown]; Region: COG4544 568707002666 DNA Polymerase Y-family; Region: PolY_like; cd03468 568707002667 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 568707002668 active site 568707002669 DNA binding site [nucleotide binding] 568707002670 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 568707002671 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 568707002672 putative active site [active] 568707002673 putative PHP Thumb interface [polypeptide binding]; other site 568707002674 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 568707002675 generic binding surface II; other site 568707002676 generic binding surface I; other site 568707002677 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 568707002678 Predicted transcriptional regulator [Transcription]; Region: COG1959 568707002679 Transcriptional regulator; Region: Rrf2; cl17282 568707002680 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 568707002681 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 568707002682 heme-binding site [chemical binding]; other site 568707002683 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 568707002684 FAD binding pocket [chemical binding]; other site 568707002685 FAD binding motif [chemical binding]; other site 568707002686 phosphate binding motif [ion binding]; other site 568707002687 beta-alpha-beta structure motif; other site 568707002688 NAD binding pocket [chemical binding]; other site 568707002689 Heme binding pocket [chemical binding]; other site 568707002690 Yqey-like protein; Region: YqeY; pfam09424 568707002691 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 568707002692 active site 568707002693 DNA polymerase IV; Validated; Region: PRK02406 568707002694 DNA binding site [nucleotide binding] 568707002695 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568707002696 CoenzymeA binding site [chemical binding]; other site 568707002697 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 568707002698 subunit interaction site [polypeptide binding]; other site 568707002699 PHB binding site; other site 568707002700 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 568707002701 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568707002702 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 568707002703 Transglycosylase; Region: Transgly; pfam00912 568707002704 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 568707002705 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 568707002706 active site 568707002707 metal binding site [ion binding]; metal-binding site 568707002708 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 568707002709 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 568707002710 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 568707002711 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 568707002712 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568707002713 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568707002714 active site 568707002715 catalytic tetrad [active] 568707002716 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568707002717 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568707002718 active site 568707002719 catalytic tetrad [active] 568707002720 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568707002721 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 568707002722 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 568707002723 Walker A/P-loop; other site 568707002724 ATP binding site [chemical binding]; other site 568707002725 Q-loop/lid; other site 568707002726 ABC transporter signature motif; other site 568707002727 Walker B; other site 568707002728 D-loop; other site 568707002729 H-loop/switch region; other site 568707002730 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 568707002731 iron-sulfur cluster [ion binding]; other site 568707002732 [2Fe-2S] cluster binding site [ion binding]; other site 568707002733 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 568707002734 dimerization interface [polypeptide binding]; other site 568707002735 putative active cleft [active] 568707002737 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568707002738 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707002739 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 568707002740 PAS domain S-box; Region: sensory_box; TIGR00229 568707002741 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707002742 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707002743 metal binding site [ion binding]; metal-binding site 568707002744 active site 568707002745 I-site; other site 568707002746 PAS domain; Region: PAS_9; pfam13426 568707002747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568707002748 putative active site [active] 568707002749 heme pocket [chemical binding]; other site 568707002750 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 568707002751 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568707002752 dimer interface [polypeptide binding]; other site 568707002753 putative CheW interface [polypeptide binding]; other site 568707002754 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 568707002755 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 568707002756 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568707002757 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 568707002758 dimer interface [polypeptide binding]; other site 568707002759 putative tRNA-binding site [nucleotide binding]; other site 568707002760 DoxX; Region: DoxX; pfam07681 568707002761 lysine transporter; Provisional; Region: PRK10836 568707002762 META domain; Region: META; pfam03724 568707002763 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 568707002764 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707002765 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 568707002766 active site 568707002767 catalytic residues [active] 568707002768 metal binding site [ion binding]; metal-binding site 568707002769 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707002770 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707002771 Propionate catabolism activator; Region: PrpR_N; pfam06506 568707002772 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 568707002773 PAS domain; Region: PAS; smart00091 568707002774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707002775 Walker A motif; other site 568707002776 ATP binding site [chemical binding]; other site 568707002777 Walker B motif; other site 568707002778 arginine finger; other site 568707002779 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 568707002780 DNA-binding interface [nucleotide binding]; DNA binding site 568707002781 inner membrane protein; Provisional; Region: PRK10995 568707002782 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 568707002783 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 568707002784 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568707002785 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707002786 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 568707002787 active site 568707002788 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707002789 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707002790 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 568707002791 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707002792 NAD(P) binding site [chemical binding]; other site 568707002793 catalytic residues [active] 568707002794 hypothetical protein; Provisional; Region: PRK07064 568707002795 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707002796 PYR/PP interface [polypeptide binding]; other site 568707002797 dimer interface [polypeptide binding]; other site 568707002798 TPP binding site [chemical binding]; other site 568707002799 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707002800 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 568707002801 TPP-binding site [chemical binding]; other site 568707002802 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707002803 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707002804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707002805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707002806 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 568707002807 putative dimerization interface [polypeptide binding]; other site 568707002808 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 568707002809 hypothetical protein; Provisional; Region: PRK04262 568707002810 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 568707002811 active site 568707002812 DUF35 OB-fold domain; Region: DUF35; pfam01796 568707002813 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 568707002814 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 568707002815 active site 568707002816 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 568707002817 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707002818 acyl-activating enzyme (AAE) consensus motif; other site 568707002819 AMP binding site [chemical binding]; other site 568707002820 active site 568707002821 CoA binding site [chemical binding]; other site 568707002822 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 568707002823 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 568707002824 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707002825 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707002826 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568707002827 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707002828 catalytic loop [active] 568707002829 iron binding site [ion binding]; other site 568707002830 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568707002831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707002832 NAD(P) binding site [chemical binding]; other site 568707002833 active site 568707002834 enoyl-CoA hydratase; Provisional; Region: PRK06688 568707002835 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707002836 substrate binding site [chemical binding]; other site 568707002837 oxyanion hole (OAH) forming residues; other site 568707002838 trimer interface [polypeptide binding]; other site 568707002839 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 568707002840 inter-subunit interface; other site 568707002841 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 568707002842 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 568707002843 iron-sulfur cluster [ion binding]; other site 568707002844 [2Fe-2S] cluster binding site [ion binding]; other site 568707002845 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 568707002846 putative alpha subunit interface [polypeptide binding]; other site 568707002847 putative active site [active] 568707002848 putative substrate binding site [chemical binding]; other site 568707002849 Fe binding site [ion binding]; other site 568707002850 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568707002851 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 568707002852 putative ligand binding site [chemical binding]; other site 568707002853 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707002854 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707002855 TM-ABC transporter signature motif; other site 568707002856 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707002857 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707002858 TM-ABC transporter signature motif; other site 568707002859 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707002860 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707002861 Walker A/P-loop; other site 568707002862 ATP binding site [chemical binding]; other site 568707002863 Q-loop/lid; other site 568707002864 ABC transporter signature motif; other site 568707002865 Walker B; other site 568707002866 D-loop; other site 568707002867 H-loop/switch region; other site 568707002868 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707002869 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707002870 Walker A/P-loop; other site 568707002871 ATP binding site [chemical binding]; other site 568707002872 Q-loop/lid; other site 568707002873 ABC transporter signature motif; other site 568707002874 Walker B; other site 568707002875 D-loop; other site 568707002876 H-loop/switch region; other site 568707002877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707002878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707002879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 568707002880 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707002881 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568707002882 homotrimer interaction site [polypeptide binding]; other site 568707002883 putative active site [active] 568707002884 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 568707002885 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 568707002886 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 568707002887 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 568707002888 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 568707002889 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 568707002890 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 568707002891 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707002892 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 568707002893 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568707002894 DNA binding residues [nucleotide binding] 568707002895 DNA primase, catalytic core; Region: dnaG; TIGR01391 568707002896 CHC2 zinc finger; Region: zf-CHC2; pfam01807 568707002897 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 568707002898 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 568707002899 interdomain interaction site; other site 568707002900 active site 568707002901 metal binding site [ion binding]; metal-binding site 568707002902 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 568707002903 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 568707002904 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 568707002905 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 568707002906 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568707002907 active site 568707002908 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 568707002909 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 568707002910 GDP-binding site [chemical binding]; other site 568707002911 ACT binding site; other site 568707002912 IMP binding site; other site 568707002913 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 568707002914 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 568707002915 dimer interface [polypeptide binding]; other site 568707002916 motif 1; other site 568707002917 active site 568707002918 motif 2; other site 568707002919 motif 3; other site 568707002920 HflC protein; Region: hflC; TIGR01932 568707002921 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 568707002922 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 568707002923 HflK protein; Region: hflK; TIGR01933 568707002924 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 568707002925 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 568707002926 HflX GTPase family; Region: HflX; cd01878 568707002927 G1 box; other site 568707002928 GTP/Mg2+ binding site [chemical binding]; other site 568707002929 Switch I region; other site 568707002930 G2 box; other site 568707002931 G3 box; other site 568707002932 Switch II region; other site 568707002933 G4 box; other site 568707002934 G5 box; other site 568707002935 bacterial Hfq-like; Region: Hfq; cd01716 568707002936 hexamer interface [polypeptide binding]; other site 568707002937 Sm1 motif; other site 568707002938 RNA binding site [nucleotide binding]; other site 568707002939 Sm2 motif; other site 568707002940 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 568707002941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707002942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707002943 homodimer interface [polypeptide binding]; other site 568707002944 catalytic residue [active] 568707002945 GTP-binding protein Der; Reviewed; Region: PRK00093 568707002946 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 568707002947 G1 box; other site 568707002948 GTP/Mg2+ binding site [chemical binding]; other site 568707002949 Switch I region; other site 568707002950 G2 box; other site 568707002951 Switch II region; other site 568707002952 G3 box; other site 568707002953 G4 box; other site 568707002954 G5 box; other site 568707002955 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 568707002956 G1 box; other site 568707002957 GTP/Mg2+ binding site [chemical binding]; other site 568707002958 Switch I region; other site 568707002959 G2 box; other site 568707002960 G3 box; other site 568707002961 Switch II region; other site 568707002962 G4 box; other site 568707002963 G5 box; other site 568707002964 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 568707002965 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 568707002966 Trp docking motif [polypeptide binding]; other site 568707002967 active site 568707002968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 568707002969 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 568707002970 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 568707002971 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 568707002972 dimer interface [polypeptide binding]; other site 568707002973 motif 1; other site 568707002974 active site 568707002975 motif 2; other site 568707002976 motif 3; other site 568707002977 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 568707002978 anticodon binding site; other site 568707002979 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 568707002980 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 568707002981 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 568707002982 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707002983 non-specific DNA binding site [nucleotide binding]; other site 568707002984 salt bridge; other site 568707002985 sequence-specific DNA binding site [nucleotide binding]; other site 568707002986 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 568707002987 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 568707002988 active site 568707002989 multimer interface [polypeptide binding]; other site 568707002990 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 568707002991 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568707002992 active site 568707002993 HIGH motif; other site 568707002994 nucleotide binding site [chemical binding]; other site 568707002995 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568707002996 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 568707002997 active site 568707002998 KMSKS motif; other site 568707002999 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 568707003000 tRNA binding surface [nucleotide binding]; other site 568707003001 anticodon binding site; other site 568707003002 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 568707003003 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 568707003004 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568707003005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707003006 active site 568707003007 phosphorylation site [posttranslational modification] 568707003008 intermolecular recognition site; other site 568707003009 dimerization interface [polypeptide binding]; other site 568707003010 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707003011 DNA binding site [nucleotide binding] 568707003012 sensor protein QseC; Provisional; Region: PRK10337 568707003013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707003014 dimer interface [polypeptide binding]; other site 568707003015 phosphorylation site [posttranslational modification] 568707003016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707003017 ATP binding site [chemical binding]; other site 568707003018 Mg2+ binding site [ion binding]; other site 568707003019 G-X-G motif; other site 568707003020 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 568707003021 homotrimer interaction site [polypeptide binding]; other site 568707003022 putative active site [active] 568707003023 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568707003024 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 568707003025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568707003026 catalytic residue [active] 568707003027 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 568707003028 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 568707003029 RimM N-terminal domain; Region: RimM; pfam01782 568707003030 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 568707003031 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 568707003032 CPxP motif; other site 568707003033 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 568707003034 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 568707003035 motif 1; other site 568707003036 active site 568707003037 motif 2; other site 568707003038 motif 3; other site 568707003039 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 568707003040 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 568707003041 Walker A motif; other site 568707003042 ATP binding site [chemical binding]; other site 568707003043 Walker B motif; other site 568707003044 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 568707003045 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 568707003046 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 568707003047 VirB7 interaction site; other site 568707003048 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 568707003049 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568707003050 Amidase; Region: Amidase; pfam01425 568707003051 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 568707003052 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707003053 Walker A/P-loop; other site 568707003054 ATP binding site [chemical binding]; other site 568707003055 Q-loop/lid; other site 568707003056 ABC transporter signature motif; other site 568707003057 Walker B; other site 568707003058 D-loop; other site 568707003059 H-loop/switch region; other site 568707003060 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707003061 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707003062 Walker A/P-loop; other site 568707003063 ATP binding site [chemical binding]; other site 568707003064 Q-loop/lid; other site 568707003065 ABC transporter signature motif; other site 568707003066 Walker B; other site 568707003067 D-loop; other site 568707003068 H-loop/switch region; other site 568707003069 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707003070 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568707003071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707003072 dimer interface [polypeptide binding]; other site 568707003073 conserved gate region; other site 568707003074 putative PBP binding loops; other site 568707003075 ABC-ATPase subunit interface; other site 568707003076 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707003077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707003078 dimer interface [polypeptide binding]; other site 568707003079 conserved gate region; other site 568707003080 putative PBP binding loops; other site 568707003081 ABC-ATPase subunit interface; other site 568707003082 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 568707003083 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 568707003084 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 568707003085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707003086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707003087 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 568707003088 putative dimerization interface [polypeptide binding]; other site 568707003089 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568707003090 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 568707003091 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 568707003092 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568707003093 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568707003094 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 568707003095 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707003096 catalytic loop [active] 568707003097 iron binding site [ion binding]; other site 568707003098 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 568707003099 FAD binding pocket [chemical binding]; other site 568707003100 FAD binding motif [chemical binding]; other site 568707003101 phosphate binding motif [ion binding]; other site 568707003102 beta-alpha-beta structure motif; other site 568707003103 NAD binding pocket [chemical binding]; other site 568707003104 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 568707003105 tetramerization interface [polypeptide binding]; other site 568707003106 active site 568707003107 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 568707003108 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 568707003109 MOSC domain; Region: MOSC; pfam03473 568707003110 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707003111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707003112 DNA-binding site [nucleotide binding]; DNA binding site 568707003113 UTRA domain; Region: UTRA; pfam07702 568707003114 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 568707003115 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 568707003116 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 568707003117 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 568707003118 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 568707003119 Ectoine synthase; Region: Ectoine_synth; pfam06339 568707003120 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 568707003121 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568707003122 inhibitor-cofactor binding pocket; inhibition site 568707003123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707003124 catalytic residue [active] 568707003125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707003126 Coenzyme A binding pocket [chemical binding]; other site 568707003128 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568707003129 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568707003130 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568707003131 putative active site [active] 568707003132 hypothetical protein; Provisional; Region: PRK07483 568707003133 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568707003134 inhibitor-cofactor binding pocket; inhibition site 568707003135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707003136 catalytic residue [active] 568707003137 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 568707003138 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 568707003139 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 568707003140 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 568707003141 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 568707003142 Protein of unknown function (DUF418); Region: DUF418; pfam04235 568707003143 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 568707003144 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 568707003145 CAP-like domain; other site 568707003146 active site 568707003147 primary dimer interface [polypeptide binding]; other site 568707003148 YcxB-like protein; Region: YcxB; pfam14317 568707003149 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 568707003150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707003151 ATP binding site [chemical binding]; other site 568707003152 Mg2+ binding site [ion binding]; other site 568707003153 G-X-G motif; other site 568707003154 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 568707003155 anchoring element; other site 568707003156 dimer interface [polypeptide binding]; other site 568707003157 ATP binding site [chemical binding]; other site 568707003158 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 568707003159 active site 568707003160 metal binding site [ion binding]; metal-binding site 568707003161 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568707003162 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568707003163 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 568707003164 catalytic residues [active] 568707003165 transcription termination factor Rho; Provisional; Region: rho; PRK09376 568707003166 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 568707003167 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 568707003168 RNA binding site [nucleotide binding]; other site 568707003169 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 568707003170 multimer interface [polypeptide binding]; other site 568707003171 Walker A motif; other site 568707003172 ATP binding site [chemical binding]; other site 568707003173 Walker B motif; other site 568707003174 TIGR02099 family protein; Region: TIGR02099 568707003175 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 568707003176 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 568707003177 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 568707003178 metal binding triad; other site 568707003179 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 568707003180 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 568707003181 metal binding triad; other site 568707003182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 568707003183 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 568707003184 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 568707003185 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 568707003186 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 568707003187 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 568707003188 Dienelactone hydrolase family; Region: DLH; pfam01738 568707003189 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 568707003190 DNA polymerase I; Provisional; Region: PRK05755 568707003191 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 568707003192 active site 568707003193 metal binding site 1 [ion binding]; metal-binding site 568707003194 putative 5' ssDNA interaction site; other site 568707003195 metal binding site 3; metal-binding site 568707003196 metal binding site 2 [ion binding]; metal-binding site 568707003197 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 568707003198 putative DNA binding site [nucleotide binding]; other site 568707003199 putative metal binding site [ion binding]; other site 568707003200 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 568707003201 active site 568707003202 catalytic site [active] 568707003203 substrate binding site [chemical binding]; other site 568707003204 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 568707003205 active site 568707003206 DNA binding site [nucleotide binding] 568707003207 catalytic site [active] 568707003208 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 568707003209 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 568707003210 Aerolysin/Pertussis toxin (APT) domain; Region: APT; pfam03440 568707003211 Pertussis toxin, subunit 2 and 3, C-terminal domain; Region: Pertussis_S2S3; pfam02918 568707003212 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 568707003213 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 568707003214 G1 box; other site 568707003215 putative GEF interaction site [polypeptide binding]; other site 568707003216 GTP/Mg2+ binding site [chemical binding]; other site 568707003217 Switch I region; other site 568707003218 G2 box; other site 568707003219 G3 box; other site 568707003220 Switch II region; other site 568707003221 G4 box; other site 568707003222 G5 box; other site 568707003223 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 568707003224 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 568707003225 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00020 568707003226 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 568707003227 RNA binding site [nucleotide binding]; other site 568707003228 active site 568707003229 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 568707003230 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568707003231 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 568707003232 translation initiation factor IF-2; Region: IF-2; TIGR00487 568707003233 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568707003234 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 568707003235 G1 box; other site 568707003236 putative GEF interaction site [polypeptide binding]; other site 568707003237 GTP/Mg2+ binding site [chemical binding]; other site 568707003238 Switch I region; other site 568707003239 G2 box; other site 568707003240 G3 box; other site 568707003241 Switch II region; other site 568707003242 G4 box; other site 568707003243 G5 box; other site 568707003244 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 568707003245 Translation-initiation factor 2; Region: IF-2; pfam11987 568707003246 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 568707003247 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 568707003248 NusA N-terminal domain; Region: NusA_N; pfam08529 568707003249 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 568707003250 RNA binding site [nucleotide binding]; other site 568707003251 homodimer interface [polypeptide binding]; other site 568707003252 NusA-like KH domain; Region: KH_5; pfam13184 568707003253 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 568707003254 G-X-X-G motif; other site 568707003255 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 568707003256 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 568707003257 ribosome maturation protein RimP; Reviewed; Region: PRK00092 568707003258 Sm and related proteins; Region: Sm_like; cl00259 568707003259 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 568707003260 putative oligomer interface [polypeptide binding]; other site 568707003261 putative RNA binding site [nucleotide binding]; other site 568707003262 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 568707003263 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568707003264 RNA binding surface [nucleotide binding]; other site 568707003265 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 568707003266 probable active site [active] 568707003267 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 568707003268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707003269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707003270 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568707003271 putative effector binding pocket; other site 568707003272 dimerization interface [polypeptide binding]; other site 568707003273 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 568707003274 putative FMN binding site [chemical binding]; other site 568707003275 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 568707003276 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568707003277 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 568707003278 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 568707003279 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 568707003280 maleylacetoacetate isomerase; Region: maiA; TIGR01262 568707003281 C-terminal domain interface [polypeptide binding]; other site 568707003282 GSH binding site (G-site) [chemical binding]; other site 568707003283 putative dimer interface [polypeptide binding]; other site 568707003284 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 568707003285 dimer interface [polypeptide binding]; other site 568707003286 N-terminal domain interface [polypeptide binding]; other site 568707003287 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 568707003288 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 568707003289 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 568707003290 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 568707003291 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 568707003292 hypothetical protein; Reviewed; Region: PRK00024 568707003293 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 568707003294 MPN+ (JAMM) motif; other site 568707003295 Zinc-binding site [ion binding]; other site 568707003296 arylformamidase; Region: trp_arylform; TIGR03035 568707003297 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 568707003298 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 568707003299 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 568707003300 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 568707003301 multidrug efflux protein; Reviewed; Region: PRK01766 568707003302 cation binding site [ion binding]; other site 568707003303 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568707003304 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 568707003305 DNA repair protein RadA; Provisional; Region: PRK11823 568707003306 Walker A motif; other site 568707003307 ATP binding site [chemical binding]; other site 568707003308 Walker B motif; other site 568707003309 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 568707003310 von Willebrand factor; Region: vWF_A; pfam12450 568707003311 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 568707003312 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 568707003313 metal ion-dependent adhesion site (MIDAS); other site 568707003314 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 568707003315 RNA polymerase sigma factor; Provisional; Region: PRK12513 568707003316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707003317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568707003318 DNA binding residues [nucleotide binding] 568707003319 short chain dehydrogenase; Provisional; Region: PRK07577 568707003320 classical (c) SDRs; Region: SDR_c; cd05233 568707003321 NAD(P) binding site [chemical binding]; other site 568707003322 active site 568707003323 alanine racemase; Reviewed; Region: alr; PRK00053 568707003324 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 568707003325 active site 568707003326 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568707003327 substrate binding site [chemical binding]; other site 568707003328 catalytic residues [active] 568707003329 dimer interface [polypeptide binding]; other site 568707003330 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 568707003331 active site lid residues [active] 568707003332 substrate binding pocket [chemical binding]; other site 568707003333 catalytic residues [active] 568707003334 substrate-Mg2+ binding site; other site 568707003335 aspartate-rich region 1; other site 568707003336 aspartate-rich region 2; other site 568707003337 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 568707003338 active site lid residues [active] 568707003339 substrate binding pocket [chemical binding]; other site 568707003340 catalytic residues [active] 568707003341 substrate-Mg2+ binding site; other site 568707003342 aspartate-rich region 1; other site 568707003343 aspartate-rich region 2; other site 568707003344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568707003345 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 568707003346 chromosome condensation membrane protein; Provisional; Region: PRK14196 568707003347 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 568707003348 ABC-2 type transporter; Region: ABC2_membrane; cl17235 568707003349 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568707003350 nodulation ABC transporter NodI; Provisional; Region: PRK13537 568707003351 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568707003352 Walker A/P-loop; other site 568707003353 ATP binding site [chemical binding]; other site 568707003354 Q-loop/lid; other site 568707003355 ABC transporter signature motif; other site 568707003356 Walker B; other site 568707003357 D-loop; other site 568707003358 H-loop/switch region; other site 568707003359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 568707003360 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 568707003361 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 568707003362 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 568707003363 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 568707003364 ApbE family; Region: ApbE; pfam02424 568707003365 Flavodoxin; Region: Flavodoxin_1; pfam00258 568707003366 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 568707003367 FAD binding pocket [chemical binding]; other site 568707003368 FAD binding motif [chemical binding]; other site 568707003369 catalytic residues [active] 568707003370 NAD binding pocket [chemical binding]; other site 568707003371 phosphate binding motif [ion binding]; other site 568707003372 beta-alpha-beta structure motif; other site 568707003373 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707003374 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 568707003375 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 568707003376 active site 568707003377 putative substrate binding pocket [chemical binding]; other site 568707003378 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568707003379 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707003380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707003381 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 568707003382 putative dimerization interface [polypeptide binding]; other site 568707003383 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 568707003384 putative hydrophobic ligand binding site [chemical binding]; other site 568707003385 protein interface [polypeptide binding]; other site 568707003386 gate; other site 568707003387 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 568707003388 hypothetical protein; Provisional; Region: PRK02399 568707003389 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 568707003390 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568707003391 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707003393 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568707003394 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707003395 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 568707003396 Clp amino terminal domain; Region: Clp_N; pfam02861 568707003397 Clp amino terminal domain; Region: Clp_N; pfam02861 568707003398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707003399 Walker A motif; other site 568707003400 ATP binding site [chemical binding]; other site 568707003401 Walker B motif; other site 568707003402 arginine finger; other site 568707003403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707003404 Walker A motif; other site 568707003405 ATP binding site [chemical binding]; other site 568707003406 Walker B motif; other site 568707003407 arginine finger; other site 568707003408 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 568707003409 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 568707003410 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568707003411 ligand binding site [chemical binding]; other site 568707003412 flexible hinge region; other site 568707003413 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 568707003414 putative switch regulator; other site 568707003415 non-specific DNA interactions [nucleotide binding]; other site 568707003416 DNA binding site [nucleotide binding] 568707003417 sequence specific DNA binding site [nucleotide binding]; other site 568707003418 putative cAMP binding site [chemical binding]; other site 568707003419 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707003420 catalytic loop [active] 568707003421 iron binding site [ion binding]; other site 568707003422 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 568707003423 dimer interface [polypeptide binding]; other site 568707003424 ADP-ribose binding site [chemical binding]; other site 568707003425 active site 568707003426 nudix motif; other site 568707003427 metal binding site [ion binding]; metal-binding site 568707003428 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 568707003429 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 568707003430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707003431 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 568707003432 DNA binding residues [nucleotide binding] 568707003433 SnoaL-like domain; Region: SnoaL_2; pfam12680 568707003434 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 568707003435 Uncharacterized conserved protein [Function unknown]; Region: COG2128 568707003436 NlpE N-terminal domain; Region: NlpE; pfam04170 568707003437 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 568707003438 Protein of unknown function (DUF342); Region: DUF342; pfam03961 568707003439 hypothetical protein; Validated; Region: PRK06201 568707003440 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 568707003441 aspartate aminotransferase; Provisional; Region: PRK06107 568707003442 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707003443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707003444 homodimer interface [polypeptide binding]; other site 568707003445 catalytic residue [active] 568707003446 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568707003447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707003448 substrate binding pocket [chemical binding]; other site 568707003449 membrane-bound complex binding site; other site 568707003450 hinge residues; other site 568707003451 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568707003452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 568707003453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707003454 dimer interface [polypeptide binding]; other site 568707003455 conserved gate region; other site 568707003456 putative PBP binding loops; other site 568707003457 ABC-ATPase subunit interface; other site 568707003458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707003459 dimer interface [polypeptide binding]; other site 568707003460 conserved gate region; other site 568707003461 putative PBP binding loops; other site 568707003462 ABC-ATPase subunit interface; other site 568707003463 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568707003464 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568707003465 Walker A/P-loop; other site 568707003466 ATP binding site [chemical binding]; other site 568707003467 Q-loop/lid; other site 568707003468 ABC transporter signature motif; other site 568707003469 Walker B; other site 568707003470 D-loop; other site 568707003471 H-loop/switch region; other site 568707003472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707003473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707003474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707003475 dimerization interface [polypeptide binding]; other site 568707003476 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568707003477 EamA-like transporter family; Region: EamA; pfam00892 568707003478 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 568707003479 dimer interface [polypeptide binding]; other site 568707003480 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568707003481 metal binding site [ion binding]; metal-binding site 568707003482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 568707003483 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 568707003484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707003485 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 568707003486 putative dimerization interface [polypeptide binding]; other site 568707003487 putative substrate binding pocket [chemical binding]; other site 568707003488 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 568707003489 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 568707003490 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 568707003491 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707003492 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707003493 metal binding site [ion binding]; metal-binding site 568707003494 active site 568707003495 I-site; other site 568707003496 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568707003497 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 568707003498 ABC-2 type transporter; Region: ABC2_membrane; cl17235 568707003499 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568707003500 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568707003501 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 568707003502 Walker A/P-loop; other site 568707003503 ATP binding site [chemical binding]; other site 568707003504 Q-loop/lid; other site 568707003505 ABC transporter signature motif; other site 568707003506 Walker B; other site 568707003507 D-loop; other site 568707003508 H-loop/switch region; other site 568707003509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568707003510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707003511 Coenzyme A binding pocket [chemical binding]; other site 568707003512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 568707003513 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 568707003514 4Fe-4S binding domain; Region: Fer4_5; pfam12801 568707003515 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 568707003516 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 568707003517 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 568707003518 Cytochrome c; Region: Cytochrom_C; pfam00034 568707003519 Cytochrome c; Region: Cytochrom_C; pfam00034 568707003520 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 568707003521 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 568707003522 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 568707003523 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 568707003524 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 568707003525 Low-spin heme binding site [chemical binding]; other site 568707003526 Putative water exit pathway; other site 568707003527 Binuclear center (active site) [active] 568707003528 Putative proton exit pathway; other site 568707003529 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 568707003530 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 568707003531 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568707003532 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 568707003533 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568707003534 inhibitor-cofactor binding pocket; inhibition site 568707003535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707003536 catalytic residue [active] 568707003537 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568707003538 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 568707003539 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568707003540 catalytic residue [active] 568707003541 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 568707003542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 568707003543 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 568707003544 AAA domain; Region: AAA_26; pfam13500 568707003545 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 568707003546 LrgA family; Region: LrgA; pfam03788 568707003547 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 568707003548 isocitrate lyase; Provisional; Region: PRK15063 568707003549 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 568707003550 tetramer interface [polypeptide binding]; other site 568707003551 active site 568707003552 Mg2+/Mn2+ binding site [ion binding]; other site 568707003553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 568707003554 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 568707003555 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 568707003556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707003557 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707003558 putative substrate translocation pore; other site 568707003559 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 568707003560 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 568707003561 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 568707003562 active site 568707003563 catalytic site [active] 568707003564 putative DNA binding site [nucleotide binding]; other site 568707003565 GIY-YIG motif/motif A; other site 568707003566 metal binding site [ion binding]; metal-binding site 568707003567 UvrB/uvrC motif; Region: UVR; pfam02151 568707003568 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 568707003569 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 568707003570 beta-hexosaminidase; Provisional; Region: PRK05337 568707003571 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 568707003572 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 568707003573 active site 568707003574 hydrophilic channel; other site 568707003575 dimerization interface [polypeptide binding]; other site 568707003576 catalytic residues [active] 568707003577 active site lid [active] 568707003578 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 568707003579 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 568707003580 Protein export membrane protein; Region: SecD_SecF; cl14618 568707003581 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 568707003582 HlyD family secretion protein; Region: HlyD_3; pfam13437 568707003583 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568707003584 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 568707003585 DNA binding site [nucleotide binding] 568707003586 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 568707003587 Patatin phospholipase; Region: DUF3734; pfam12536 568707003588 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 568707003589 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 568707003590 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 568707003591 molybdenum-pterin binding domain; Region: Mop; TIGR00638 568707003592 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 568707003593 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 568707003594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707003595 Walker A/P-loop; other site 568707003596 ATP binding site [chemical binding]; other site 568707003597 Q-loop/lid; other site 568707003598 ABC transporter signature motif; other site 568707003599 Walker B; other site 568707003600 D-loop; other site 568707003601 H-loop/switch region; other site 568707003602 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707003603 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 568707003604 TM-ABC transporter signature motif; other site 568707003605 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 568707003606 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 568707003607 zinc binding site [ion binding]; other site 568707003608 putative ligand binding site [chemical binding]; other site 568707003609 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 568707003610 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 568707003611 E-class dimer interface [polypeptide binding]; other site 568707003612 P-class dimer interface [polypeptide binding]; other site 568707003613 active site 568707003614 Cu2+ binding site [ion binding]; other site 568707003615 Zn2+ binding site [ion binding]; other site 568707003616 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707003617 malonyl-CoA synthase; Validated; Region: PRK07514 568707003618 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 568707003619 acyl-activating enzyme (AAE) consensus motif; other site 568707003620 active site 568707003621 AMP binding site [chemical binding]; other site 568707003622 CoA binding site [chemical binding]; other site 568707003623 enoyl-CoA hydratase; Provisional; Region: PRK06127 568707003624 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707003625 substrate binding site [chemical binding]; other site 568707003626 oxyanion hole (OAH) forming residues; other site 568707003627 trimer interface [polypeptide binding]; other site 568707003628 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 568707003629 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 568707003630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707003631 DNA-binding site [nucleotide binding]; DNA binding site 568707003632 FCD domain; Region: FCD; pfam07729 568707003634 beta-ketothiolase; Provisional; Region: PRK09051 568707003635 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568707003636 dimer interface [polypeptide binding]; other site 568707003637 active site 568707003638 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 568707003639 active site 1 [active] 568707003640 dimer interface [polypeptide binding]; other site 568707003641 hexamer interface [polypeptide binding]; other site 568707003642 active site 2 [active] 568707003643 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 568707003644 dimer interface [polypeptide binding]; other site 568707003645 hexamer interface [polypeptide binding]; other site 568707003646 active site 2 [active] 568707003647 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 568707003648 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 568707003649 Walker A/P-loop; other site 568707003650 ATP binding site [chemical binding]; other site 568707003651 Q-loop/lid; other site 568707003652 ABC transporter signature motif; other site 568707003653 Walker B; other site 568707003654 D-loop; other site 568707003655 H-loop/switch region; other site 568707003656 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 568707003657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707003658 dimer interface [polypeptide binding]; other site 568707003659 conserved gate region; other site 568707003660 putative PBP binding loops; other site 568707003661 ABC-ATPase subunit interface; other site 568707003662 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 568707003663 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568707003664 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 568707003665 Methyltransferase domain; Region: Methyltransf_25; pfam13649 568707003666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707003667 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 568707003668 putative substrate translocation pore; other site 568707003669 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 568707003670 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 568707003671 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 568707003672 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 568707003673 Sulfate transporter family; Region: Sulfate_transp; pfam00916 568707003674 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 568707003675 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 568707003676 IHF - DNA interface [nucleotide binding]; other site 568707003677 IHF dimer interface [polypeptide binding]; other site 568707003678 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568707003679 MarR family; Region: MarR_2; cl17246 568707003680 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 568707003681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707003682 putative substrate translocation pore; other site 568707003683 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 568707003684 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 568707003685 HIGH motif; other site 568707003686 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568707003687 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568707003688 active site 568707003689 KMSKS motif; other site 568707003690 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 568707003691 tRNA binding surface [nucleotide binding]; other site 568707003692 Lipopolysaccharide-assembly; Region: LptE; pfam04390 568707003693 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 568707003694 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 568707003695 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 568707003696 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 568707003697 putative catalytic cysteine [active] 568707003698 amidase; Provisional; Region: PRK07487 568707003699 Amidase; Region: Amidase; cl11426 568707003700 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 568707003701 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568707003702 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568707003703 Predicted acetyltransferase [General function prediction only]; Region: COG2388 568707003704 hypothetical protein; Provisional; Region: PRK01842 568707003705 ribonuclease G; Provisional; Region: PRK11712 568707003706 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 568707003707 homodimer interface [polypeptide binding]; other site 568707003708 oligonucleotide binding site [chemical binding]; other site 568707003709 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 568707003710 Prephenate dehydratase; Region: PDT; pfam00800 568707003711 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 568707003712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707003713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707003714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707003715 putative substrate translocation pore; other site 568707003716 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 568707003717 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568707003718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707003719 Walker A/P-loop; other site 568707003720 ATP binding site [chemical binding]; other site 568707003721 Q-loop/lid; other site 568707003722 ABC transporter signature motif; other site 568707003723 Walker B; other site 568707003724 D-loop; other site 568707003725 H-loop/switch region; other site 568707003726 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568707003727 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 568707003728 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568707003729 Uncharacterized conserved protein [Function unknown]; Region: COG1434 568707003730 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568707003731 putative active site [active] 568707003732 Flagellin N-methylase; Region: FliB; pfam03692 568707003733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707003734 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568707003735 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 568707003736 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 568707003737 putative active site [active] 568707003738 putative metal binding site [ion binding]; other site 568707003739 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 568707003740 Sulfatase; Region: Sulfatase; cl17466 568707003741 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707003742 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568707003743 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568707003744 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 568707003745 putative metal binding site; other site 568707003746 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 568707003747 putative active site [active] 568707003748 putative metal binding site [ion binding]; other site 568707003749 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568707003750 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707003751 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 568707003752 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 568707003753 putative active site [active] 568707003754 putative PHP Thumb interface [polypeptide binding]; other site 568707003755 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 568707003756 generic binding surface I; other site 568707003757 generic binding surface II; other site 568707003758 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 568707003759 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 568707003760 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568707003761 ATP binding site [chemical binding]; other site 568707003762 putative Mg++ binding site [ion binding]; other site 568707003763 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568707003764 nucleotide binding region [chemical binding]; other site 568707003765 ATP-binding site [chemical binding]; other site 568707003766 Helicase associated domain (HA2); Region: HA2; pfam04408 568707003767 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 568707003768 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 568707003769 N-acetylglutamate synthase; Validated; Region: PRK05279 568707003770 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 568707003771 putative feedback inhibition sensing region; other site 568707003772 putative nucleotide binding site [chemical binding]; other site 568707003773 putative substrate binding site [chemical binding]; other site 568707003774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707003775 Coenzyme A binding pocket [chemical binding]; other site 568707003776 oxidative damage protection protein; Provisional; Region: PRK05408 568707003777 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 568707003778 Phosphoesterase family; Region: Phosphoesterase; pfam04185 568707003779 Domain of unknown function (DUF756); Region: DUF756; pfam05506 568707003780 transcriptional regulator PhoU; Provisional; Region: PRK11115 568707003781 PhoU domain; Region: PhoU; pfam01895 568707003782 PhoU domain; Region: PhoU; pfam01895 568707003783 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 568707003784 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568707003785 active site 568707003786 dimer interface [polypeptide binding]; other site 568707003787 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 568707003788 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707003789 active site 568707003790 RmuC family; Region: RmuC; pfam02646 568707003791 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; pfam10707 568707003792 3-methyladenine DNA glycosylase; Reviewed; Region: PRK00802 568707003793 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 568707003794 ArsC family; Region: ArsC; pfam03960 568707003795 putative catalytic residues [active] 568707003796 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568707003797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707003798 dimer interface [polypeptide binding]; other site 568707003799 conserved gate region; other site 568707003800 putative PBP binding loops; other site 568707003801 ABC-ATPase subunit interface; other site 568707003802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707003803 dimer interface [polypeptide binding]; other site 568707003804 conserved gate region; other site 568707003805 putative PBP binding loops; other site 568707003806 ABC-ATPase subunit interface; other site 568707003807 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 568707003808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707003809 Walker A/P-loop; other site 568707003810 ATP binding site [chemical binding]; other site 568707003811 Q-loop/lid; other site 568707003812 ABC transporter signature motif; other site 568707003813 Walker B; other site 568707003814 D-loop; other site 568707003815 H-loop/switch region; other site 568707003816 TOBE domain; Region: TOBE_2; pfam08402 568707003817 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 568707003818 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568707003819 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 568707003820 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 568707003821 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 568707003822 apolar tunnel; other site 568707003823 heme binding site [chemical binding]; other site 568707003824 dimerization interface [polypeptide binding]; other site 568707003825 FtsX-like permease family; Region: FtsX; pfam02687 568707003827 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707003828 DctM-like transporters; Region: DctM; pfam06808 568707003829 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568707003830 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 568707003831 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 568707003832 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 568707003833 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 568707003834 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 568707003835 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 568707003836 active site 568707003837 AMP binding site [chemical binding]; other site 568707003838 homodimer interface [polypeptide binding]; other site 568707003839 acyl-activating enzyme (AAE) consensus motif; other site 568707003840 CoA binding site [chemical binding]; other site 568707003841 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568707003842 CoenzymeA binding site [chemical binding]; other site 568707003843 subunit interaction site [polypeptide binding]; other site 568707003844 PHB binding site; other site 568707003845 enoyl-CoA hydratase; Provisional; Region: PRK08140 568707003846 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707003847 substrate binding site [chemical binding]; other site 568707003848 oxyanion hole (OAH) forming residues; other site 568707003849 trimer interface [polypeptide binding]; other site 568707003850 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 568707003851 Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Region: ALDH_PAD-PaaZ; cd07127 568707003852 NADP binding site [chemical binding]; other site 568707003853 catalytic residues [active] 568707003854 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 568707003855 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 568707003856 FAD binding pocket [chemical binding]; other site 568707003857 FAD binding motif [chemical binding]; other site 568707003858 phosphate binding motif [ion binding]; other site 568707003859 beta-alpha-beta structure motif; other site 568707003860 NAD(p) ribose binding residues [chemical binding]; other site 568707003861 NAD binding pocket [chemical binding]; other site 568707003862 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 568707003863 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707003864 catalytic loop [active] 568707003865 iron binding site [ion binding]; other site 568707003866 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 568707003867 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 568707003868 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 568707003869 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 568707003870 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 568707003871 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 568707003872 PaaX-like protein; Region: PaaX; pfam07848 568707003873 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 568707003874 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 568707003875 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 568707003876 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 568707003877 catalytic site [active] 568707003878 putative active site [active] 568707003879 putative substrate binding site [chemical binding]; other site 568707003880 dimer interface [polypeptide binding]; other site 568707003881 Peptidase family M48; Region: Peptidase_M48; pfam01435 568707003882 GTPase RsgA; Reviewed; Region: PRK00098 568707003883 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 568707003884 RNA binding site [nucleotide binding]; other site 568707003885 homodimer interface [polypeptide binding]; other site 568707003886 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 568707003887 GTPase/Zn-binding domain interface [polypeptide binding]; other site 568707003888 GTP/Mg2+ binding site [chemical binding]; other site 568707003889 G4 box; other site 568707003890 G5 box; other site 568707003891 G1 box; other site 568707003892 Switch I region; other site 568707003893 G2 box; other site 568707003894 G3 box; other site 568707003895 Switch II region; other site 568707003896 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568707003897 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568707003898 active site 568707003899 catalytic tetrad [active] 568707003900 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 568707003901 putative active site [active] 568707003902 putative CoA binding site [chemical binding]; other site 568707003903 nudix motif; other site 568707003904 metal binding site [ion binding]; metal-binding site 568707003905 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 568707003906 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 568707003907 EamA-like transporter family; Region: EamA; cl17759 568707003908 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 568707003909 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 568707003910 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 568707003911 CysD dimerization site [polypeptide binding]; other site 568707003912 G1 box; other site 568707003913 putative GEF interaction site [polypeptide binding]; other site 568707003914 GTP/Mg2+ binding site [chemical binding]; other site 568707003915 Switch I region; other site 568707003916 G2 box; other site 568707003917 G3 box; other site 568707003918 Switch II region; other site 568707003919 G4 box; other site 568707003920 G5 box; other site 568707003921 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 568707003922 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 568707003923 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 568707003924 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 568707003925 Active Sites [active] 568707003926 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 568707003927 Active Sites [active] 568707003928 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 568707003929 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 568707003930 Walker A/P-loop; other site 568707003931 ATP binding site [chemical binding]; other site 568707003932 Q-loop/lid; other site 568707003933 ABC transporter signature motif; other site 568707003934 Walker B; other site 568707003935 D-loop; other site 568707003936 H-loop/switch region; other site 568707003937 TOBE-like domain; Region: TOBE_3; pfam12857 568707003938 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 568707003939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707003940 dimer interface [polypeptide binding]; other site 568707003941 conserved gate region; other site 568707003942 putative PBP binding loops; other site 568707003943 ABC-ATPase subunit interface; other site 568707003944 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 568707003945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707003946 dimer interface [polypeptide binding]; other site 568707003947 conserved gate region; other site 568707003948 putative PBP binding loops; other site 568707003949 ABC-ATPase subunit interface; other site 568707003950 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 568707003951 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568707003952 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 568707003953 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 568707003954 dimer interface [polypeptide binding]; other site 568707003955 decamer (pentamer of dimers) interface [polypeptide binding]; other site 568707003956 catalytic triad [active] 568707003957 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 568707003958 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 568707003959 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707003960 active site 568707003961 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 568707003962 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 568707003963 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 568707003964 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 568707003965 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 568707003966 Ligand binding site [chemical binding]; other site 568707003967 Electron transfer flavoprotein domain; Region: ETF; pfam01012 568707003968 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 568707003969 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 568707003970 putative active site [active] 568707003971 Zn binding site [ion binding]; other site 568707003972 Transglycosylase SLT domain; Region: SLT_2; pfam13406 568707003973 NIL domain; Region: NIL; cl09633 568707003974 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568707003975 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568707003976 cysteine synthase B; Region: cysM; TIGR01138 568707003977 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 568707003978 dimer interface [polypeptide binding]; other site 568707003979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707003980 catalytic residue [active] 568707003981 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 568707003982 Helix-hairpin-helix motif; Region: HHH; pfam00633 568707003983 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 568707003984 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 568707003985 NADP binding site [chemical binding]; other site 568707003986 homopentamer interface [polypeptide binding]; other site 568707003987 substrate binding site [chemical binding]; other site 568707003988 active site 568707003989 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 568707003990 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 568707003991 putative ribose interaction site [chemical binding]; other site 568707003992 putative ADP binding site [chemical binding]; other site 568707003993 tetratricopeptide repeat protein; Provisional; Region: PRK11788 568707003994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568707003995 binding surface 568707003996 TPR motif; other site 568707003997 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568707003998 IHF - DNA interface [nucleotide binding]; other site 568707003999 IHF dimer interface [polypeptide binding]; other site 568707004000 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 568707004001 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 568707004002 RNA binding site [nucleotide binding]; other site 568707004003 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 568707004004 RNA binding site [nucleotide binding]; other site 568707004005 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 568707004006 RNA binding site [nucleotide binding]; other site 568707004007 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 568707004008 RNA binding site [nucleotide binding]; other site 568707004009 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 568707004010 RNA binding site [nucleotide binding]; other site 568707004011 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 568707004012 RNA binding site [nucleotide binding]; other site 568707004013 cytidylate kinase; Provisional; Region: cmk; PRK00023 568707004014 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 568707004015 CMP-binding site; other site 568707004016 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 568707004017 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 568707004018 hinge; other site 568707004019 active site 568707004020 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 568707004021 prephenate dehydrogenase; Validated; Region: PRK08507 568707004022 Chorismate mutase type II; Region: CM_2; cl00693 568707004023 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 568707004024 Prephenate dehydratase; Region: PDT; pfam00800 568707004025 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 568707004026 putative L-Phe binding site [chemical binding]; other site 568707004027 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 568707004028 homodimer interface [polypeptide binding]; other site 568707004029 substrate-cofactor binding pocket; other site 568707004030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707004031 catalytic residue [active] 568707004032 DNA gyrase subunit A; Validated; Region: PRK05560 568707004033 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 568707004034 CAP-like domain; other site 568707004035 active site 568707004036 primary dimer interface [polypeptide binding]; other site 568707004037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568707004038 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568707004039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568707004040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568707004041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568707004042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568707004043 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 568707004044 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568707004045 ligand binding site [chemical binding]; other site 568707004046 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 568707004047 Methyltransferase domain; Region: Methyltransf_32; pfam13679 568707004048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707004049 S-adenosylmethionine binding site [chemical binding]; other site 568707004050 phosphoglycolate phosphatase; Provisional; Region: PRK13226 568707004051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707004052 motif II; other site 568707004053 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 568707004054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707004055 putative substrate translocation pore; other site 568707004056 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 568707004057 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 568707004058 catalytic residue [active] 568707004059 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 568707004060 Phage-related protein, tail component [Function unknown]; Region: COG4733 568707004061 Putative phage tail protein; Region: Phage-tail_3; pfam13550 568707004062 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 568707004063 NlpC/P60 family; Region: NLPC_P60; cl17555 568707004066 hypothetical protein; Region: PHA00660 568707004067 hypothetical protein; Region: PHA00661 568707004068 hypothetical protein; Region: PHA00662 568707004069 hypothetical protein; Region: PHA00663 568707004070 hypothetical protein; Region: PHA00664 568707004071 major capsid protein; Region: PHA00665 568707004072 putative protease; Region: PHA00666 568707004073 hypothetical protein; Region: PHA00670 568707004074 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 568707004075 hypothetical protein; Region: PHA00672 568707004076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707004077 Coenzyme A binding pocket [chemical binding]; other site 568707004078 hypothetical protein; Region: PHA00675 568707004079 hypothetical protein; Region: PHA00687 568707004080 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 568707004081 active site 568707004082 putative DNA-binding cleft [nucleotide binding]; other site 568707004083 dimer interface [polypeptide binding]; other site 568707004084 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 568707004085 AAA domain; Region: AAA_25; pfam13481 568707004086 Walker A motif; other site 568707004087 ATP binding site [chemical binding]; other site 568707004088 Walker B motif; other site 568707004089 Predicted transcriptional regulator [Transcription]; Region: COG2932 568707004090 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 568707004091 Catalytic site [active] 568707004092 RecT family; Region: RecT; pfam03837 568707004093 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 568707004095 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 568707004096 integrase; Provisional; Region: int; PHA02601 568707004097 Rci recombinase, C-terminal catalytic domain. Rci enzymes are found in IncI1 incompatibility group plasmids such as R64. These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796 568707004098 catalytic residues [active] 568707004099 Int/Topo IB signature motif; other site 568707004100 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 568707004101 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707004102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707004103 homodimer interface [polypeptide binding]; other site 568707004104 catalytic residue [active] 568707004105 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 568707004106 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 568707004107 trimer interface [polypeptide binding]; other site 568707004108 active site 568707004109 substrate binding site [chemical binding]; other site 568707004110 CoA binding site [chemical binding]; other site 568707004111 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 568707004112 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 568707004113 metal binding site [ion binding]; metal-binding site 568707004114 dimer interface [polypeptide binding]; other site 568707004115 HemK family putative methylases; Region: hemK_fam; TIGR00536 568707004116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707004117 S-adenosylmethionine binding site [chemical binding]; other site 568707004118 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 568707004119 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568707004120 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568707004121 ABC transporter; Region: ABC_tran_2; pfam12848 568707004122 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568707004123 Secretin and TonB N terminus short domain; Region: STN; smart00965 568707004124 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 568707004125 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 568707004126 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 568707004127 Part of AAA domain; Region: AAA_19; pfam13245 568707004128 Family description; Region: UvrD_C_2; pfam13538 568707004129 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 568707004130 Fatty acid desaturase; Region: FA_desaturase; pfam00487 568707004131 Di-iron ligands [ion binding]; other site 568707004132 16S rRNA methyltransferase B; Provisional; Region: PRK10901 568707004133 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 568707004134 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 568707004135 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 568707004136 active site 568707004137 substrate binding site [chemical binding]; other site 568707004138 cosubstrate binding site; other site 568707004139 catalytic site [active] 568707004140 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 568707004141 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 568707004142 active site 568707004143 Riboflavin kinase; Region: Flavokinase; smart00904 568707004144 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 568707004145 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568707004146 active site 568707004147 HIGH motif; other site 568707004148 nucleotide binding site [chemical binding]; other site 568707004149 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 568707004150 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 568707004151 active site 568707004152 KMSKS motif; other site 568707004153 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 568707004154 tRNA binding surface [nucleotide binding]; other site 568707004155 anticodon binding site; other site 568707004156 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568707004157 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 568707004158 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 568707004159 Flavoprotein; Region: Flavoprotein; pfam02441 568707004160 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 568707004161 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 568707004162 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568707004163 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707004164 putative DNA binding site [nucleotide binding]; other site 568707004165 putative Zn2+ binding site [ion binding]; other site 568707004166 AsnC family; Region: AsnC_trans_reg; pfam01037 568707004167 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 568707004168 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568707004169 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 568707004170 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 568707004171 trimer interface [polypeptide binding]; other site 568707004172 active site 568707004173 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568707004174 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568707004175 Walker A/P-loop; other site 568707004176 ATP binding site [chemical binding]; other site 568707004177 Q-loop/lid; other site 568707004178 ABC transporter signature motif; other site 568707004179 Walker B; other site 568707004180 D-loop; other site 568707004181 H-loop/switch region; other site 568707004182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707004183 dimer interface [polypeptide binding]; other site 568707004184 conserved gate region; other site 568707004185 putative PBP binding loops; other site 568707004186 ABC-ATPase subunit interface; other site 568707004187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707004188 dimer interface [polypeptide binding]; other site 568707004189 conserved gate region; other site 568707004190 putative PBP binding loops; other site 568707004191 ABC-ATPase subunit interface; other site 568707004192 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 568707004193 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707004194 substrate binding pocket [chemical binding]; other site 568707004195 membrane-bound complex binding site; other site 568707004196 hinge residues; other site 568707004197 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568707004198 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 568707004199 putative ligand binding site [chemical binding]; other site 568707004200 ornithine cyclodeaminase; Validated; Region: PRK06141 568707004201 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 568707004202 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 568707004203 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 568707004204 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 568707004205 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 568707004206 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 568707004207 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568707004208 dimerization domain swap beta strand [polypeptide binding]; other site 568707004209 regulatory protein interface [polypeptide binding]; other site 568707004210 active site 568707004211 regulatory phosphorylation site [posttranslational modification]; other site 568707004212 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 568707004213 active pocket/dimerization site; other site 568707004214 active site 568707004215 phosphorylation site [posttranslational modification] 568707004216 glutathione synthetase; Provisional; Region: PRK05246 568707004217 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 568707004218 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 568707004219 translation initiation factor IF-3; Region: infC; TIGR00168 568707004220 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 568707004221 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 568707004222 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 568707004223 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 568707004224 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 568707004225 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 568707004226 active site 568707004227 dimer interface [polypeptide binding]; other site 568707004228 motif 1; other site 568707004229 motif 2; other site 568707004230 motif 3; other site 568707004231 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 568707004232 anticodon binding site; other site 568707004233 Response regulator receiver domain; Region: Response_reg; pfam00072 568707004234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707004235 active site 568707004236 phosphorylation site [posttranslational modification] 568707004237 intermolecular recognition site; other site 568707004238 dimerization interface [polypeptide binding]; other site 568707004239 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707004240 DNA binding residues [nucleotide binding] 568707004241 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 568707004242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568707004243 FeS/SAM binding site; other site 568707004244 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 568707004245 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 568707004246 amphipathic channel; other site 568707004247 Asn-Pro-Ala signature motifs; other site 568707004248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 568707004249 YheO-like PAS domain; Region: PAS_6; pfam08348 568707004250 HTH domain; Region: HTH_22; pfam13309 568707004251 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707004252 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 568707004253 Uncharacterized conserved protein [Function unknown]; Region: COG5476 568707004254 MlrC C-terminus; Region: MlrC_C; pfam07171 568707004255 Protein of unknown function (DUF497); Region: DUF497; pfam04365 568707004256 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 568707004257 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 568707004258 active site 568707004259 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 568707004260 DctM-like transporters; Region: DctM; pfam06808 568707004261 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 568707004262 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 568707004263 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 568707004264 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707004265 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 568707004266 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 568707004267 dimerization interface 3.5A [polypeptide binding]; other site 568707004268 active site 568707004269 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568707004270 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 568707004271 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 568707004272 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 568707004273 tartrate dehydrogenase; Region: TTC; TIGR02089 568707004274 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 568707004275 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 568707004276 substrate binding site [chemical binding]; other site 568707004277 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 568707004278 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 568707004279 substrate binding site [chemical binding]; other site 568707004280 ligand binding site [chemical binding]; other site 568707004281 PBP superfamily domain; Region: PBP_like_2; pfam12849 568707004282 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568707004283 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 568707004284 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568707004285 Walker A/P-loop; other site 568707004286 ATP binding site [chemical binding]; other site 568707004287 Q-loop/lid; other site 568707004288 ABC transporter signature motif; other site 568707004289 Walker B; other site 568707004290 D-loop; other site 568707004291 H-loop/switch region; other site 568707004292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707004293 dimer interface [polypeptide binding]; other site 568707004294 conserved gate region; other site 568707004295 putative PBP binding loops; other site 568707004296 ABC-ATPase subunit interface; other site 568707004297 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 568707004298 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 568707004299 PBP superfamily domain; Region: PBP_like; pfam12727 568707004300 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 568707004301 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 568707004302 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 568707004303 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 568707004304 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 568707004305 [4Fe-4S] binding site [ion binding]; other site 568707004306 molybdopterin cofactor binding site; other site 568707004307 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568707004308 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 568707004309 molybdopterin cofactor binding site; other site 568707004310 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 568707004311 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 568707004312 4Fe-4S binding domain; Region: Fer4; pfam00037 568707004313 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 568707004314 4Fe-4S binding domain; Region: Fer4; pfam00037 568707004315 4Fe-4S binding domain; Region: Fer4; pfam00037 568707004316 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 568707004317 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 568707004318 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 568707004319 Domain of unknown function DUF59; Region: DUF59; pfam01883 568707004320 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 568707004321 Walker A motif; other site 568707004322 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 568707004323 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 568707004324 GTP binding site; other site 568707004325 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 568707004326 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 568707004327 dimer interface [polypeptide binding]; other site 568707004328 putative functional site; other site 568707004329 putative MPT binding site; other site 568707004330 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 568707004331 Walker A motif; other site 568707004332 Peptidase family M48; Region: Peptidase_M48; pfam01435 568707004333 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 568707004334 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 568707004335 Tetramer interface [polypeptide binding]; other site 568707004336 active site 568707004337 FMN-binding site [chemical binding]; other site 568707004338 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707004339 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707004340 I-site; other site 568707004341 active site 568707004342 metal binding site [ion binding]; metal-binding site 568707004343 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568707004344 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707004345 metal binding site [ion binding]; metal-binding site 568707004346 active site 568707004347 I-site; other site 568707004348 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568707004349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568707004350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707004351 dimer interface [polypeptide binding]; other site 568707004352 phosphorylation site [posttranslational modification] 568707004353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707004354 ATP binding site [chemical binding]; other site 568707004355 Mg2+ binding site [ion binding]; other site 568707004356 G-X-G motif; other site 568707004357 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568707004358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707004359 active site 568707004360 phosphorylation site [posttranslational modification] 568707004361 intermolecular recognition site; other site 568707004362 dimerization interface [polypeptide binding]; other site 568707004363 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 568707004364 DNA binding site [nucleotide binding] 568707004365 hypothetical protein; Validated; Region: PRK00029 568707004366 Uncharacterized conserved protein [Function unknown]; Region: COG0397 568707004367 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 568707004368 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 568707004369 FOG: CBS domain [General function prediction only]; Region: COG0517 568707004370 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625 568707004371 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 568707004372 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 568707004373 FMN binding site [chemical binding]; other site 568707004374 active site 568707004375 catalytic residues [active] 568707004376 substrate binding site [chemical binding]; other site 568707004377 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 568707004378 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 568707004379 putative active site [active] 568707004380 putative substrate binding site [chemical binding]; other site 568707004381 ATP binding site [chemical binding]; other site 568707004382 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 568707004383 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 568707004384 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 568707004385 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 568707004386 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 568707004387 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 568707004388 phosphopeptide binding site; other site 568707004389 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 568707004390 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 568707004391 ATP binding site [chemical binding]; other site 568707004392 Walker A motif; other site 568707004393 hexamer interface [polypeptide binding]; other site 568707004394 Walker B motif; other site 568707004395 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 568707004396 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 568707004397 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 568707004398 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 568707004399 Predicted small secreted protein [Function unknown]; Region: COG5510 568707004400 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568707004401 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568707004402 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 568707004403 dimer interface [polypeptide binding]; other site 568707004404 substrate binding site [chemical binding]; other site 568707004405 metal binding sites [ion binding]; metal-binding site 568707004406 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 568707004407 HemY protein N-terminus; Region: HemY_N; pfam07219 568707004408 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 568707004409 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 568707004410 active site 568707004411 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 568707004412 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 568707004413 domain interfaces; other site 568707004414 active site 568707004415 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 568707004416 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 568707004417 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 568707004418 CoA binding domain; Region: CoA_binding; smart00881 568707004419 CoA-ligase; Region: Ligase_CoA; pfam00549 568707004420 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 568707004421 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 568707004422 CoA-ligase; Region: Ligase_CoA; pfam00549 568707004423 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 568707004424 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 568707004425 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 568707004426 THF binding site; other site 568707004427 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 568707004428 substrate binding site [chemical binding]; other site 568707004429 THF binding site; other site 568707004430 zinc-binding site [ion binding]; other site 568707004431 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 568707004432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707004433 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 568707004434 putative dimerization interface [polypeptide binding]; other site 568707004435 RecX family; Region: RecX; cl00936 568707004436 recombinase A; Provisional; Region: recA; PRK09354 568707004437 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 568707004438 hexamer interface [polypeptide binding]; other site 568707004439 Walker A motif; other site 568707004440 ATP binding site [chemical binding]; other site 568707004441 Walker B motif; other site 568707004442 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568707004443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707004444 active site 568707004445 phosphorylation site [posttranslational modification] 568707004446 intermolecular recognition site; other site 568707004447 dimerization interface [polypeptide binding]; other site 568707004448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707004449 DNA binding site [nucleotide binding] 568707004450 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 568707004451 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568707004452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707004453 dimer interface [polypeptide binding]; other site 568707004454 phosphorylation site [posttranslational modification] 568707004455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707004456 ATP binding site [chemical binding]; other site 568707004457 G-X-G motif; other site 568707004458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707004459 putative substrate translocation pore; other site 568707004460 enoyl-CoA hydratase; Provisional; Region: PRK06144 568707004461 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707004462 substrate binding site [chemical binding]; other site 568707004463 oxyanion hole (OAH) forming residues; other site 568707004464 trimer interface [polypeptide binding]; other site 568707004465 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568707004466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707004467 Walker A/P-loop; other site 568707004468 ATP binding site [chemical binding]; other site 568707004469 Q-loop/lid; other site 568707004470 ABC transporter signature motif; other site 568707004471 Walker B; other site 568707004472 D-loop; other site 568707004473 H-loop/switch region; other site 568707004474 TOBE domain; Region: TOBE_2; pfam08402 568707004475 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 568707004476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707004477 dimer interface [polypeptide binding]; other site 568707004478 conserved gate region; other site 568707004479 putative PBP binding loops; other site 568707004480 ABC-ATPase subunit interface; other site 568707004481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707004482 dimer interface [polypeptide binding]; other site 568707004483 conserved gate region; other site 568707004484 putative PBP binding loops; other site 568707004485 ABC-ATPase subunit interface; other site 568707004486 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568707004487 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 568707004488 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568707004489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707004490 NAD(P) binding site [chemical binding]; other site 568707004491 active site 568707004492 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707004493 active site 2 [active] 568707004494 active site 1 [active] 568707004495 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 568707004496 DUF35 OB-fold domain; Region: DUF35; pfam01796 568707004497 thiolase; Provisional; Region: PRK06158 568707004498 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 568707004499 active site 568707004500 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568707004501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707004502 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707004503 dimerization interface [polypeptide binding]; other site 568707004504 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707004505 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707004506 recombination associated protein; Reviewed; Region: rdgC; PRK00321 568707004507 aspartate carbamoyltransferase; Provisional; Region: PRK11891 568707004508 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 568707004509 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 568707004510 Entericidin EcnA/B family; Region: Entericidin; cl02322 568707004511 Endonuclease I; Region: Endonuclease_1; pfam04231 568707004513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707004514 DNA-binding site [nucleotide binding]; DNA binding site 568707004515 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 568707004516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707004517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707004518 homodimer interface [polypeptide binding]; other site 568707004519 catalytic residue [active] 568707004520 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568707004521 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 568707004522 AsnC family; Region: AsnC_trans_reg; pfam01037 568707004523 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 568707004524 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 568707004525 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568707004526 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707004527 Coenzyme A binding pocket [chemical binding]; other site 568707004528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707004529 S-adenosylmethionine binding site [chemical binding]; other site 568707004530 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 568707004531 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 568707004532 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 568707004533 DNA binding residues [nucleotide binding] 568707004534 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568707004535 IHF - DNA interface [nucleotide binding]; other site 568707004536 IHF dimer interface [polypeptide binding]; other site 568707004537 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 568707004538 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 568707004539 putative tRNA-binding site [nucleotide binding]; other site 568707004540 B3/4 domain; Region: B3_4; pfam03483 568707004541 tRNA synthetase B5 domain; Region: B5; smart00874 568707004542 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 568707004543 dimer interface [polypeptide binding]; other site 568707004544 motif 1; other site 568707004545 motif 3; other site 568707004546 motif 2; other site 568707004547 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 568707004548 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 568707004549 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 568707004550 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 568707004551 dimer interface [polypeptide binding]; other site 568707004552 motif 1; other site 568707004553 active site 568707004554 motif 2; other site 568707004555 motif 3; other site 568707004556 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 568707004557 23S rRNA binding site [nucleotide binding]; other site 568707004558 L21 binding site [polypeptide binding]; other site 568707004559 L13 binding site [polypeptide binding]; other site 568707004560 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 568707004561 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 568707004562 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 568707004563 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 568707004564 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 568707004565 Membrane fusogenic activity; Region: BMFP; pfam04380 568707004566 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 568707004567 Nitrogen regulatory protein P-II; Region: P-II; smart00938 568707004568 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 568707004570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707004571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707004572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707004573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707004574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707004575 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707004576 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707004577 Walker A/P-loop; other site 568707004578 ATP binding site [chemical binding]; other site 568707004579 Q-loop/lid; other site 568707004580 ABC transporter signature motif; other site 568707004581 Walker B; other site 568707004582 D-loop; other site 568707004583 H-loop/switch region; other site 568707004584 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707004585 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707004586 Walker A/P-loop; other site 568707004587 ATP binding site [chemical binding]; other site 568707004588 Q-loop/lid; other site 568707004589 ABC transporter signature motif; other site 568707004590 Walker B; other site 568707004591 D-loop; other site 568707004592 H-loop/switch region; other site 568707004593 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707004594 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707004595 TM-ABC transporter signature motif; other site 568707004596 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707004597 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707004598 TM-ABC transporter signature motif; other site 568707004599 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568707004600 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 568707004601 dimerization interface [polypeptide binding]; other site 568707004602 ligand binding site [chemical binding]; other site 568707004603 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 568707004604 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 568707004605 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 568707004606 Glutamate binding site [chemical binding]; other site 568707004607 NAD binding site [chemical binding]; other site 568707004608 catalytic residues [active] 568707004609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 568707004610 Protein of unknown function (DUF330); Region: DUF330; pfam03886 568707004611 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 568707004612 mce related protein; Region: MCE; pfam02470 568707004613 mce related protein; Region: MCE; pfam02470 568707004614 mce related protein; Region: MCE; pfam02470 568707004615 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 568707004616 Paraquat-inducible protein A; Region: PqiA; pfam04403 568707004617 Paraquat-inducible protein A; Region: PqiA; pfam04403 568707004618 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 568707004619 Clp amino terminal domain; Region: Clp_N; pfam02861 568707004620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707004621 Walker A motif; other site 568707004622 ATP binding site [chemical binding]; other site 568707004623 Walker B motif; other site 568707004624 arginine finger; other site 568707004625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707004626 Walker A motif; other site 568707004627 ATP binding site [chemical binding]; other site 568707004628 Walker B motif; other site 568707004629 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 568707004630 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 568707004631 Transglycosylase; Region: Transgly; pfam00912 568707004632 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 568707004633 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 568707004634 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 568707004635 MG2 domain; Region: A2M_N; pfam01835 568707004636 Alpha-2-macroglobulin family; Region: A2M; pfam00207 568707004637 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 568707004638 surface patch; other site 568707004639 thioester region; other site 568707004640 specificity defining residues; other site 568707004641 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 568707004642 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568707004643 DNA-binding site [nucleotide binding]; DNA binding site 568707004644 RNA-binding motif; other site 568707004645 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 568707004646 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 568707004647 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568707004648 dimer interface [polypeptide binding]; other site 568707004649 active site 568707004650 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 568707004651 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 568707004652 putative ion selectivity filter; other site 568707004653 putative pore gating glutamate residue; other site 568707004654 putative H+/Cl- coupling transport residue; other site 568707004655 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 568707004656 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 568707004657 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 568707004658 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 568707004659 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 568707004660 generic binding surface II; other site 568707004661 generic binding surface I; other site 568707004662 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 568707004663 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 568707004664 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 568707004665 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 568707004666 Uncharacterized conserved protein [Function unknown]; Region: COG2835 568707004667 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 568707004668 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 568707004669 Ligand binding site; other site 568707004670 oligomer interface; other site 568707004671 adenylate kinase; Reviewed; Region: adk; PRK00279 568707004672 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 568707004673 AMP-binding site [chemical binding]; other site 568707004674 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 568707004675 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 568707004676 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 568707004677 NAD binding site [chemical binding]; other site 568707004678 homodimer interface [polypeptide binding]; other site 568707004679 homotetramer interface [polypeptide binding]; other site 568707004680 active site 568707004681 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 568707004682 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 568707004683 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 568707004684 FecR protein; Region: FecR; pfam04773 568707004685 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 568707004686 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 568707004687 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707004688 dihydroxy-acid dehydratase; Validated; Region: PRK06131 568707004689 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 568707004690 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568707004691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707004692 DNA-binding site [nucleotide binding]; DNA binding site 568707004693 FCD domain; Region: FCD; pfam07729 568707004694 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 568707004695 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 568707004696 inhibitor site; inhibition site 568707004697 active site 568707004698 dimer interface [polypeptide binding]; other site 568707004699 catalytic residue [active] 568707004701 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 568707004702 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 568707004703 putative ligand binding site [chemical binding]; other site 568707004704 NAD binding site [chemical binding]; other site 568707004705 catalytic site [active] 568707004706 short chain dehydrogenase; Provisional; Region: PRK12744 568707004707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707004708 NAD(P) binding site [chemical binding]; other site 568707004709 active site 568707004710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707004711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707004712 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 568707004713 putative effector binding pocket; other site 568707004714 putative dimerization interface [polypeptide binding]; other site 568707004715 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 568707004716 acetylornithine aminotransferase; Provisional; Region: PRK02627 568707004717 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568707004718 inhibitor-cofactor binding pocket; inhibition site 568707004719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707004720 catalytic residue [active] 568707004721 ornithine carbamoyltransferase; Provisional; Region: PRK00779 568707004722 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 568707004723 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 568707004724 argininosuccinate synthase; Validated; Region: PRK05370 568707004725 argininosuccinate synthase; Provisional; Region: PRK13820 568707004726 K+ potassium transporter; Region: K_trans; cl15781 568707004727 potassium uptake protein; Region: kup; TIGR00794 568707004728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568707004729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707004730 dimer interface [polypeptide binding]; other site 568707004731 phosphorylation site [posttranslational modification] 568707004732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707004733 ATP binding site [chemical binding]; other site 568707004734 Mg2+ binding site [ion binding]; other site 568707004735 G-X-G motif; other site 568707004736 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568707004737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707004738 active site 568707004739 phosphorylation site [posttranslational modification] 568707004740 intermolecular recognition site; other site 568707004741 dimerization interface [polypeptide binding]; other site 568707004742 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707004743 DNA binding site [nucleotide binding] 568707004744 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 568707004745 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 568707004746 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 568707004747 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 568707004748 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 568707004749 IHF dimer interface [polypeptide binding]; other site 568707004750 IHF - DNA interface [nucleotide binding]; other site 568707004751 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 568707004752 hypothetical protein; Provisional; Region: PRK05939 568707004753 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568707004754 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568707004755 catalytic residue [active] 568707004756 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 568707004757 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 568707004758 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568707004760 DTW domain; Region: DTW; cl01221 568707004761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 568707004762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707004763 Coenzyme A binding pocket [chemical binding]; other site 568707004764 Predicted permeases [General function prediction only]; Region: COG0679 568707004765 Sulphur transport; Region: Sulf_transp; pfam04143 568707004766 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 568707004767 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 568707004768 active site 568707004769 FMN binding site [chemical binding]; other site 568707004770 substrate binding site [chemical binding]; other site 568707004771 3Fe-4S cluster binding site [ion binding]; other site 568707004772 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 568707004773 PLD-like domain; Region: PLDc_2; pfam13091 568707004774 putative active site [active] 568707004775 catalytic site [active] 568707004776 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 568707004777 PLD-like domain; Region: PLDc_2; pfam13091 568707004778 putative active site [active] 568707004779 catalytic site [active] 568707004780 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 568707004781 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 568707004782 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 568707004783 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 568707004784 ABC transporter G family member; Provisional; Region: PLN03140 568707004785 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 568707004786 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568707004787 Zn2+ binding site [ion binding]; other site 568707004788 Mg2+ binding site [ion binding]; other site 568707004789 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 568707004790 heme-binding site [chemical binding]; other site 568707004791 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707004792 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707004793 metal binding site [ion binding]; metal-binding site 568707004794 active site 568707004795 I-site; other site 568707004796 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 568707004797 Isochorismatase family; Region: Isochorismatase; pfam00857 568707004798 catalytic triad [active] 568707004799 metal binding site [ion binding]; metal-binding site 568707004800 conserved cis-peptide bond; other site 568707004801 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568707004802 Domain of unknown function DUF20; Region: UPF0118; pfam01594 568707004803 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 568707004804 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 568707004805 Cytochrome C' Region: Cytochrom_C_2; pfam01322 568707004806 adenylosuccinate lyase; Provisional; Region: PRK09285 568707004807 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 568707004808 tetramer interface [polypeptide binding]; other site 568707004809 active site 568707004810 putative glutathione S-transferase; Provisional; Region: PRK10357 568707004811 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 568707004812 putative C-terminal domain interface [polypeptide binding]; other site 568707004813 putative GSH binding site (G-site) [chemical binding]; other site 568707004814 putative dimer interface [polypeptide binding]; other site 568707004815 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 568707004816 dimer interface [polypeptide binding]; other site 568707004817 N-terminal domain interface [polypeptide binding]; other site 568707004818 putative substrate binding pocket (H-site) [chemical binding]; other site 568707004819 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568707004820 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 568707004821 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 568707004822 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568707004823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707004824 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707004825 dimerization interface [polypeptide binding]; other site 568707004826 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707004827 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 568707004828 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 568707004829 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 568707004830 ligand binding site [chemical binding]; other site 568707004831 homodimer interface [polypeptide binding]; other site 568707004832 NAD(P) binding site [chemical binding]; other site 568707004833 trimer interface B [polypeptide binding]; other site 568707004834 trimer interface A [polypeptide binding]; other site 568707004835 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 568707004836 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 568707004837 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 568707004838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707004839 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568707004840 outer membrane receptor FepA; Provisional; Region: PRK13528 568707004841 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707004842 N-terminal plug; other site 568707004843 ligand-binding site [chemical binding]; other site 568707004844 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 568707004845 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 568707004846 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 568707004847 Cysteine-rich domain; Region: CCG; pfam02754 568707004848 Cysteine-rich domain; Region: CCG; pfam02754 568707004849 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 568707004850 FAD binding domain; Region: FAD_binding_4; pfam01565 568707004851 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 568707004852 FAD binding domain; Region: FAD_binding_4; pfam01565 568707004853 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 568707004854 FAD binding domain; Region: FAD_binding_4; pfam01565 568707004855 haemagglutination activity domain; Region: Haemagg_act; pfam05860 568707004856 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 568707004857 Peptidase C80 family; Region: Peptidase_C80; pfam11713 568707004858 Peptidase C80 family; Region: Peptidase_C80; pfam11713 568707004859 Peptidase C80 family; Region: Peptidase_C80; pfam11713 568707004860 Peptidase C80 family; Region: Peptidase_C80; pfam11713 568707004861 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 568707004862 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 568707004863 protease TldD; Provisional; Region: tldD; PRK10735 568707004864 nitrilase; Region: PLN02798 568707004865 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 568707004866 putative active site [active] 568707004867 catalytic triad [active] 568707004868 dimer interface [polypeptide binding]; other site 568707004869 H-NS histone family; Region: Histone_HNS; pfam00816 568707004870 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 568707004871 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 568707004872 aminopeptidase N; Provisional; Region: pepN; PRK14015 568707004873 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 568707004874 active site 568707004875 Zn binding site [ion binding]; other site 568707004876 fructose-1,6-bisphosphatase family protein; Region: PLN02628 568707004877 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 568707004878 AMP binding site [chemical binding]; other site 568707004879 metal binding site [ion binding]; metal-binding site 568707004880 active site 568707004881 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 568707004882 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 568707004883 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 568707004884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707004885 catalytic residue [active] 568707004886 homoserine dehydrogenase; Provisional; Region: PRK06349 568707004887 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 568707004888 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 568707004889 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 568707004890 aminotransferase; Validated; Region: PRK08175 568707004891 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707004892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707004893 homodimer interface [polypeptide binding]; other site 568707004894 catalytic residue [active] 568707004895 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 568707004896 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 568707004897 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 568707004898 catalytic triad [active] 568707004899 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 568707004900 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 568707004901 putative active site [active] 568707004902 PhoH-like protein; Region: PhoH; pfam02562 568707004903 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 568707004904 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 568707004905 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 568707004906 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 568707004907 replicative DNA helicase; Provisional; Region: PRK07004 568707004908 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 568707004909 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 568707004910 Walker A motif; other site 568707004911 ATP binding site [chemical binding]; other site 568707004912 Walker B motif; other site 568707004913 DNA binding loops [nucleotide binding] 568707004914 serine/threonine protein kinase; Provisional; Region: PRK14879 568707004915 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 568707004916 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 568707004917 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 568707004918 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 568707004919 primosomal replication protein N; Reviewed; Region: PRK00036 568707004920 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 568707004921 putative GTP cyclohydrolase; Provisional; Region: PRK13674 568707004922 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 568707004923 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 568707004924 TPP-binding site; other site 568707004925 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568707004926 PYR/PP interface [polypeptide binding]; other site 568707004927 dimer interface [polypeptide binding]; other site 568707004928 TPP binding site [chemical binding]; other site 568707004929 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568707004930 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568707004931 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568707004932 substrate binding pocket [chemical binding]; other site 568707004933 chain length determination region; other site 568707004934 substrate-Mg2+ binding site; other site 568707004935 catalytic residues [active] 568707004936 aspartate-rich region 1; other site 568707004937 active site lid residues [active] 568707004938 aspartate-rich region 2; other site 568707004939 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 568707004940 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707004941 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707004942 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707004943 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707004944 Acyltransferase family; Region: Acyl_transf_3; pfam01757 568707004945 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 568707004946 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 568707004947 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 568707004948 [2Fe-2S] cluster binding site [ion binding]; other site 568707004949 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 568707004950 alpha subunit interface [polypeptide binding]; other site 568707004951 active site 568707004952 substrate binding site [chemical binding]; other site 568707004953 Fe binding site [ion binding]; other site 568707004954 Secretin and TonB N terminus short domain; Region: STN; smart00965 568707004955 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 568707004956 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 568707004957 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 568707004958 RNA polymerase sigma factor; Provisional; Region: PRK12529 568707004959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707004960 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 568707004961 DNA binding residues [nucleotide binding] 568707004962 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568707004963 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 568707004964 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568707004965 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568707004966 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 568707004967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707004968 motif II; other site 568707004969 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 568707004970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707004971 putative PBP binding loops; other site 568707004972 dimer interface [polypeptide binding]; other site 568707004973 ABC-ATPase subunit interface; other site 568707004974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707004975 dimer interface [polypeptide binding]; other site 568707004976 conserved gate region; other site 568707004977 putative PBP binding loops; other site 568707004978 ABC-ATPase subunit interface; other site 568707004979 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 568707004980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707004981 Walker A/P-loop; other site 568707004982 ATP binding site [chemical binding]; other site 568707004983 Q-loop/lid; other site 568707004984 ABC transporter signature motif; other site 568707004985 Walker B; other site 568707004986 D-loop; other site 568707004987 H-loop/switch region; other site 568707004988 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 568707004989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707004990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707004991 dimerization interface [polypeptide binding]; other site 568707004992 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 568707004993 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 568707004994 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 568707004995 active site residue [active] 568707004996 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 568707004997 active site residue [active] 568707004998 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568707004999 heat shock protein HtpX; Provisional; Region: PRK05457 568707005000 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 568707005001 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 568707005002 NADP binding site [chemical binding]; other site 568707005003 dimer interface [polypeptide binding]; other site 568707005004 EamA-like transporter family; Region: EamA; pfam00892 568707005005 EamA-like transporter family; Region: EamA; pfam00892 568707005006 MarR family; Region: MarR_2; cl17246 568707005007 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568707005008 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 568707005009 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 568707005010 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568707005011 HlyD family secretion protein; Region: HlyD_3; pfam13437 568707005012 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568707005013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707005014 putative substrate translocation pore; other site 568707005015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707005016 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 568707005017 tartrate dehydrogenase; Region: TTC; TIGR02089 568707005018 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 568707005019 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707005020 DNA-binding site [nucleotide binding]; DNA binding site 568707005021 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707005022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707005023 homodimer interface [polypeptide binding]; other site 568707005024 catalytic residue [active] 568707005025 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568707005026 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 568707005027 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707005028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707005029 dimer interface [polypeptide binding]; other site 568707005030 conserved gate region; other site 568707005031 putative PBP binding loops; other site 568707005032 ABC-ATPase subunit interface; other site 568707005033 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568707005034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707005035 putative PBP binding loops; other site 568707005036 dimer interface [polypeptide binding]; other site 568707005037 ABC-ATPase subunit interface; other site 568707005038 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 568707005039 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707005040 Walker A/P-loop; other site 568707005041 ATP binding site [chemical binding]; other site 568707005042 Q-loop/lid; other site 568707005043 ABC transporter signature motif; other site 568707005044 Walker B; other site 568707005045 D-loop; other site 568707005046 H-loop/switch region; other site 568707005047 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568707005048 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707005049 Walker A/P-loop; other site 568707005050 ATP binding site [chemical binding]; other site 568707005051 Q-loop/lid; other site 568707005052 ABC transporter signature motif; other site 568707005053 Walker B; other site 568707005054 D-loop; other site 568707005055 H-loop/switch region; other site 568707005056 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707005057 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 568707005058 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568707005059 inhibitor-cofactor binding pocket; inhibition site 568707005060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707005061 catalytic residue [active] 568707005062 Cupin domain; Region: Cupin_2; cl17218 568707005063 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 568707005064 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 568707005065 active site 568707005066 Zn binding site [ion binding]; other site 568707005067 allantoate amidohydrolase; Reviewed; Region: PRK12893 568707005068 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 568707005069 active site 568707005070 metal binding site [ion binding]; metal-binding site 568707005071 dimer interface [polypeptide binding]; other site 568707005072 EamA-like transporter family; Region: EamA; pfam00892 568707005073 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568707005074 EamA-like transporter family; Region: EamA; pfam00892 568707005075 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707005076 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 568707005077 NAD(P) binding site [chemical binding]; other site 568707005078 catalytic residues [active] 568707005079 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 568707005080 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 568707005081 putative ligand binding site [chemical binding]; other site 568707005082 NAD binding site [chemical binding]; other site 568707005083 dimerization interface [polypeptide binding]; other site 568707005084 catalytic site [active] 568707005085 aminotransferase; Provisional; Region: PRK06105 568707005086 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568707005087 inhibitor-cofactor binding pocket; inhibition site 568707005088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707005089 catalytic residue [active] 568707005090 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 568707005091 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 568707005092 hypothetical protein; Validated; Region: PRK00110 568707005093 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 568707005094 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 568707005095 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 568707005096 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 568707005097 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 568707005098 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 568707005099 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 568707005100 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 568707005101 active site 568707005102 (T/H)XGH motif; other site 568707005103 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 568707005104 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 568707005105 Maf-like protein; Region: Maf; pfam02545 568707005106 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 568707005107 active site 568707005108 dimer interface [polypeptide binding]; other site 568707005109 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 568707005110 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568707005111 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707005112 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568707005113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707005114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707005115 dimerization interface [polypeptide binding]; other site 568707005116 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 568707005117 Sodium Bile acid symporter family; Region: SBF; pfam01758 568707005118 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 568707005119 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 568707005120 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 568707005122 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 568707005123 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 568707005124 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568707005125 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 568707005126 EamA-like transporter family; Region: EamA; pfam00892 568707005127 YciI-like protein; Reviewed; Region: PRK12866 568707005128 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 568707005129 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 568707005130 homodimer interface [polypeptide binding]; other site 568707005131 chemical substrate binding site [chemical binding]; other site 568707005132 oligomer interface [polypeptide binding]; other site 568707005133 metal binding site [ion binding]; metal-binding site 568707005134 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568707005135 active site 568707005136 catalytic site [active] 568707005137 substrate binding site [chemical binding]; other site 568707005138 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 568707005139 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 568707005140 substrate binding site [chemical binding]; other site 568707005141 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 568707005142 substrate binding site [chemical binding]; other site 568707005143 ligand binding site [chemical binding]; other site 568707005144 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 568707005145 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 568707005146 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568707005147 ligand binding site [chemical binding]; other site 568707005148 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 568707005149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707005150 motif II; other site 568707005151 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 568707005152 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707005153 N-terminal plug; other site 568707005154 ligand-binding site [chemical binding]; other site 568707005155 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568707005156 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568707005157 catalytic residue [active] 568707005158 aconitate hydratase; Provisional; Region: acnA; PRK12881 568707005159 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 568707005160 substrate binding site [chemical binding]; other site 568707005161 ligand binding site [chemical binding]; other site 568707005162 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 568707005163 substrate binding site [chemical binding]; other site 568707005164 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 568707005165 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 568707005166 putative active site [active] 568707005167 metal binding site [ion binding]; metal-binding site 568707005168 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 568707005169 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 568707005170 elongation factor P; Validated; Region: PRK00529 568707005171 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 568707005172 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 568707005173 RNA binding site [nucleotide binding]; other site 568707005174 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 568707005175 RNA binding site [nucleotide binding]; other site 568707005176 Cytochrome c; Region: Cytochrom_C; cl11414 568707005177 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 568707005178 dinuclear metal binding motif [ion binding]; other site 568707005179 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 568707005180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707005181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568707005182 DNA binding residues [nucleotide binding] 568707005183 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 568707005184 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 568707005185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707005186 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568707005187 Walker A motif; other site 568707005188 ATP binding site [chemical binding]; other site 568707005189 Walker B motif; other site 568707005190 arginine finger; other site 568707005191 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 568707005192 Predicted membrane protein [Function unknown]; Region: COG4655 568707005193 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 568707005194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 568707005195 TPR motif; other site 568707005196 binding surface 568707005197 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 568707005198 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 568707005199 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 568707005200 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 568707005201 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 568707005202 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 568707005203 ATP binding site [chemical binding]; other site 568707005204 Walker A motif; other site 568707005205 hexamer interface [polypeptide binding]; other site 568707005206 Walker B motif; other site 568707005207 AAA domain; Region: AAA_31; pfam13614 568707005208 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 568707005209 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 568707005210 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 568707005211 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 568707005212 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 568707005213 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 568707005214 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 568707005215 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 568707005216 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 568707005217 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 568707005218 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 568707005219 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 568707005220 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 568707005221 MarR family; Region: MarR_2; pfam12802 568707005222 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 568707005223 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707005224 Walker A/P-loop; other site 568707005225 ATP binding site [chemical binding]; other site 568707005226 Q-loop/lid; other site 568707005227 ABC transporter signature motif; other site 568707005228 Walker B; other site 568707005229 D-loop; other site 568707005230 H-loop/switch region; other site 568707005231 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707005232 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707005233 Walker A/P-loop; other site 568707005234 ATP binding site [chemical binding]; other site 568707005235 Q-loop/lid; other site 568707005236 ABC transporter signature motif; other site 568707005237 Walker B; other site 568707005238 D-loop; other site 568707005239 H-loop/switch region; other site 568707005240 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707005241 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568707005242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707005243 dimer interface [polypeptide binding]; other site 568707005244 conserved gate region; other site 568707005245 putative PBP binding loops; other site 568707005246 ABC-ATPase subunit interface; other site 568707005247 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707005248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707005249 dimer interface [polypeptide binding]; other site 568707005250 conserved gate region; other site 568707005251 putative PBP binding loops; other site 568707005252 ABC-ATPase subunit interface; other site 568707005253 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 568707005254 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 568707005255 Staphylococcal nuclease homologues; Region: SNc; smart00318 568707005256 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 568707005257 Catalytic site; other site 568707005258 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 568707005259 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 568707005260 oligomer interface [polypeptide binding]; other site 568707005261 metal binding site [ion binding]; metal-binding site 568707005262 metal binding site [ion binding]; metal-binding site 568707005263 putative Cl binding site [ion binding]; other site 568707005264 basic sphincter; other site 568707005265 hydrophobic gate; other site 568707005266 periplasmic entrance; other site 568707005267 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 568707005268 Part of AAA domain; Region: AAA_19; pfam13245 568707005269 Family description; Region: UvrD_C_2; pfam13538 568707005270 Protein of unknown function DUF72; Region: DUF72; pfam01904 568707005271 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 568707005272 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707005273 DNA-binding site [nucleotide binding]; DNA binding site 568707005274 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707005275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707005276 homodimer interface [polypeptide binding]; other site 568707005277 catalytic residue [active] 568707005279 succinic semialdehyde dehydrogenase; Region: PLN02278 568707005280 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 568707005281 tetramerization interface [polypeptide binding]; other site 568707005282 NAD(P) binding site [chemical binding]; other site 568707005283 catalytic residues [active] 568707005284 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 568707005285 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568707005286 active site 568707005287 putative lithium-binding site [ion binding]; other site 568707005288 substrate binding site [chemical binding]; other site 568707005289 NAD-dependent deacetylase; Provisional; Region: PRK05333 568707005290 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 568707005291 serine O-acetyltransferase; Region: cysE; TIGR01172 568707005292 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 568707005293 trimer interface [polypeptide binding]; other site 568707005294 active site 568707005295 substrate binding site [chemical binding]; other site 568707005296 CoA binding site [chemical binding]; other site 568707005297 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 568707005298 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 568707005299 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 568707005300 dimer interface [polypeptide binding]; other site 568707005301 active site 568707005302 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 568707005303 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 568707005304 active site 568707005305 substrate binding site [chemical binding]; other site 568707005306 metal binding site [ion binding]; metal-binding site 568707005307 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568707005308 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707005309 DNA binding residues [nucleotide binding] 568707005310 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568707005311 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707005312 DNA binding residues [nucleotide binding] 568707005313 dimerization interface [polypeptide binding]; other site 568707005314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707005315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707005316 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 568707005317 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707005318 active site 568707005319 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 568707005320 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 568707005321 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568707005322 dimer interface [polypeptide binding]; other site 568707005323 active site 568707005324 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707005325 fatty oxidation complex, alpha subunit FadJ; Region: FadJ; TIGR02440 568707005326 substrate binding site [chemical binding]; other site 568707005327 oxyanion hole (OAH) forming residues; other site 568707005328 trimer interface [polypeptide binding]; other site 568707005329 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568707005330 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568707005331 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 568707005332 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 568707005333 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568707005334 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568707005335 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568707005336 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707005337 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707005338 substrate binding site [chemical binding]; other site 568707005339 oxyanion hole (OAH) forming residues; other site 568707005340 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 568707005341 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568707005342 dimer interface [polypeptide binding]; other site 568707005343 active site 568707005344 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707005345 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 568707005346 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 568707005347 acyl-activating enzyme (AAE) consensus motif; other site 568707005348 putative AMP binding site [chemical binding]; other site 568707005349 putative active site [active] 568707005350 putative CoA binding site [chemical binding]; other site 568707005351 Sulfatase; Region: Sulfatase; cl17466 568707005352 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 568707005354 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568707005355 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 568707005356 MarR family; Region: MarR_2; cl17246 568707005357 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 568707005358 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707005359 N-terminal plug; other site 568707005360 ligand-binding site [chemical binding]; other site 568707005361 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 568707005362 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 568707005363 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 568707005364 FAD binding pocket [chemical binding]; other site 568707005365 FAD binding motif [chemical binding]; other site 568707005366 phosphate binding motif [ion binding]; other site 568707005367 beta-alpha-beta structure motif; other site 568707005368 NAD binding pocket [chemical binding]; other site 568707005369 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 568707005370 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 568707005371 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 568707005372 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 568707005373 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 568707005374 Isochorismatase family; Region: Isochorismatase; pfam00857 568707005375 catalytic triad [active] 568707005376 conserved cis-peptide bond; other site 568707005377 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 568707005378 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568707005379 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 568707005380 hypothetical protein; Provisional; Region: PRK06847 568707005381 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568707005382 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 568707005383 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707005384 catalytic loop [active] 568707005385 iron binding site [ion binding]; other site 568707005386 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 568707005387 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 568707005388 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 568707005389 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 568707005390 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707005391 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707005392 Walker A/P-loop; other site 568707005393 ATP binding site [chemical binding]; other site 568707005394 Q-loop/lid; other site 568707005395 ABC transporter signature motif; other site 568707005396 Walker B; other site 568707005397 D-loop; other site 568707005398 H-loop/switch region; other site 568707005399 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707005400 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707005401 Walker A/P-loop; other site 568707005402 ATP binding site [chemical binding]; other site 568707005403 Q-loop/lid; other site 568707005404 ABC transporter signature motif; other site 568707005405 Walker B; other site 568707005406 D-loop; other site 568707005407 H-loop/switch region; other site 568707005408 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707005409 TM-ABC transporter signature motif; other site 568707005410 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707005411 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707005412 TM-ABC transporter signature motif; other site 568707005413 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707005414 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 568707005415 putative ligand binding site [chemical binding]; other site 568707005416 MarR family; Region: MarR_2; cl17246 568707005417 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568707005418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568707005419 TPR motif; other site 568707005420 TPR repeat; Region: TPR_11; pfam13414 568707005421 binding surface 568707005422 Tetratricopeptide repeat; Region: TPR_16; pfam13432 568707005423 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 568707005424 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 568707005425 putative active site [active] 568707005426 putative metal binding site [ion binding]; other site 568707005427 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 568707005428 N-glycosyltransferase; Provisional; Region: PRK11204 568707005429 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 568707005430 DXD motif; other site 568707005431 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568707005432 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 568707005433 FMN binding site [chemical binding]; other site 568707005434 active site 568707005435 substrate binding site [chemical binding]; other site 568707005436 catalytic residue [active] 568707005437 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707005438 dimerization interface [polypeptide binding]; other site 568707005439 putative DNA binding site [nucleotide binding]; other site 568707005440 putative Zn2+ binding site [ion binding]; other site 568707005441 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707005442 active site 2 [active] 568707005443 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 568707005444 active site 568707005445 catalytic site [active] 568707005446 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 568707005447 active site 568707005448 catalytic site [active] 568707005449 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568707005450 homotrimer interaction site [polypeptide binding]; other site 568707005451 putative active site [active] 568707005452 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707005453 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 568707005454 CoA binding domain; Region: CoA_binding_2; pfam13380 568707005455 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 568707005456 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 568707005457 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707005458 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707005459 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568707005460 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 568707005461 active site 568707005462 FMN binding site [chemical binding]; other site 568707005463 substrate binding site [chemical binding]; other site 568707005464 putative catalytic residue [active] 568707005465 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568707005466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707005467 Walker A/P-loop; other site 568707005468 ATP binding site [chemical binding]; other site 568707005469 Q-loop/lid; other site 568707005470 ABC transporter signature motif; other site 568707005471 Walker B; other site 568707005472 D-loop; other site 568707005473 H-loop/switch region; other site 568707005474 TOBE domain; Region: TOBE_2; pfam08402 568707005475 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568707005476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707005477 dimer interface [polypeptide binding]; other site 568707005478 conserved gate region; other site 568707005479 putative PBP binding loops; other site 568707005480 ABC-ATPase subunit interface; other site 568707005481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707005482 dimer interface [polypeptide binding]; other site 568707005483 conserved gate region; other site 568707005484 putative PBP binding loops; other site 568707005485 ABC-ATPase subunit interface; other site 568707005486 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 568707005487 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 568707005488 active site 568707005489 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568707005490 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 568707005491 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568707005492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707005493 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 568707005494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707005495 dimerization interface [polypeptide binding]; other site 568707005496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707005497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707005498 short chain dehydrogenase; Provisional; Region: PRK06138 568707005499 classical (c) SDRs; Region: SDR_c; cd05233 568707005500 NAD(P) binding site [chemical binding]; other site 568707005501 active site 568707005502 putative L-aspartate dehydrogenase; Provisional; Region: PRK13301 568707005503 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 568707005504 Domain of unknown function DUF108; Region: DUF108; pfam01958 568707005505 pyrimidine utilization protein D; Region: RutD; TIGR03611 568707005506 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707005507 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707005508 DctM-like transporters; Region: DctM; pfam06808 568707005509 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568707005510 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 568707005511 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 568707005512 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568707005513 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568707005514 NIPSNAP; Region: NIPSNAP; pfam07978 568707005515 Cupin domain; Region: Cupin_2; pfam07883 568707005516 aspartate kinase; Reviewed; Region: PRK06635 568707005517 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 568707005518 putative nucleotide binding site [chemical binding]; other site 568707005519 putative catalytic residues [active] 568707005520 putative Mg ion binding site [ion binding]; other site 568707005521 putative aspartate binding site [chemical binding]; other site 568707005522 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 568707005523 putative allosteric regulatory site; other site 568707005524 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 568707005525 putative allosteric regulatory residue; other site 568707005526 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 568707005527 TilS substrate binding domain; Region: TilS; pfam09179 568707005528 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 568707005529 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 568707005530 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568707005531 endonuclease III; Region: ENDO3c; smart00478 568707005532 minor groove reading motif; other site 568707005533 helix-hairpin-helix signature motif; other site 568707005534 substrate binding pocket [chemical binding]; other site 568707005535 active site 568707005536 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 568707005537 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568707005538 active site 568707005539 HIGH motif; other site 568707005540 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568707005541 KMSKS motif; other site 568707005542 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 568707005543 tRNA binding surface [nucleotide binding]; other site 568707005544 anticodon binding site; other site 568707005545 TPR repeat; Region: TPR_11; pfam13414 568707005546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568707005547 binding surface 568707005548 TPR motif; other site 568707005549 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 568707005550 substrate binding site [chemical binding]; other site 568707005551 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568707005552 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 568707005553 putative active site [active] 568707005554 putative metal binding site [ion binding]; other site 568707005555 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 568707005556 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 568707005557 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 568707005558 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568707005559 Transporter associated domain; Region: CorC_HlyC; smart01091 568707005560 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568707005561 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 568707005562 active site 568707005563 dimerization interface [polypeptide binding]; other site 568707005564 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 568707005565 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 568707005566 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707005567 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707005568 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 568707005569 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707005570 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 568707005571 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568707005572 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 568707005573 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 568707005574 Imelysin; Region: Peptidase_M75; cl09159 568707005575 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 568707005576 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 568707005577 Imelysin; Region: Peptidase_M75; cl09159 568707005578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 568707005579 Predicted flavoprotein [General function prediction only]; Region: COG0431 568707005580 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568707005581 Dodecin; Region: Dodecin; pfam07311 568707005582 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 568707005583 MutS domain I; Region: MutS_I; pfam01624 568707005584 MutS domain II; Region: MutS_II; pfam05188 568707005585 MutS domain III; Region: MutS_III; pfam05192 568707005586 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 568707005587 Walker A/P-loop; other site 568707005588 ATP binding site [chemical binding]; other site 568707005589 Q-loop/lid; other site 568707005590 ABC transporter signature motif; other site 568707005591 Walker B; other site 568707005592 D-loop; other site 568707005593 H-loop/switch region; other site 568707005594 Cupin superfamily protein; Region: Cupin_4; pfam08007 568707005595 Cupin-like domain; Region: Cupin_8; pfam13621 568707005596 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 568707005597 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 568707005598 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 568707005599 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 568707005600 dihydrodipicolinate synthase; Region: dapA; TIGR00674 568707005601 dimer interface [polypeptide binding]; other site 568707005602 active site 568707005603 catalytic residue [active] 568707005604 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 568707005605 Peptidase family M50; Region: Peptidase_M50; pfam02163 568707005606 active site 568707005607 putative substrate binding region [chemical binding]; other site 568707005608 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 568707005609 Predicted metalloprotease [General function prediction only]; Region: COG2321 568707005610 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 568707005611 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 568707005612 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 568707005613 putative active site [active] 568707005614 catalytic site [active] 568707005615 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 568707005616 putative active site [active] 568707005617 catalytic site [active] 568707005618 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 568707005619 anti sigma factor interaction site; other site 568707005620 regulatory phosphorylation site [posttranslational modification]; other site 568707005621 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 568707005622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 568707005623 ATP binding site [chemical binding]; other site 568707005624 Mg2+ binding site [ion binding]; other site 568707005625 G-X-G motif; other site 568707005626 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 568707005627 alanine racemase; Reviewed; Region: alr; PRK00053 568707005628 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568707005629 catalytic residue [active] 568707005630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707005631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707005632 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 568707005633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707005634 dimerization interface [polypeptide binding]; other site 568707005635 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 568707005636 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 568707005637 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568707005638 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 568707005640 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 568707005641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707005642 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 568707005643 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 568707005644 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 568707005645 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 568707005646 Tir chaperone protein (CesT) family; Region: CesT; cl08444 568707005647 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 568707005648 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 568707005649 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 568707005650 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 568707005651 type III secretion system protein YscR; Provisional; Region: PRK12797 568707005652 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 568707005653 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 568707005654 Type III secretion protein YscO; Region: YscO; pfam07321 568707005655 type III secretion system ATPase; Provisional; Region: PRK06936 568707005656 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568707005657 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 568707005658 Walker A motif/ATP binding site; other site 568707005659 Walker B motif; other site 568707005660 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 568707005661 Flagellar assembly protein FliH; Region: FliH; pfam02108 568707005662 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 568707005663 Type III secretion needle MxiH like; Region: MxiH; pfam09392 568707005664 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 568707005665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568707005666 binding surface 568707005667 TPR motif; other site 568707005668 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 568707005669 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 568707005670 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 568707005671 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 568707005672 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 568707005673 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 568707005674 FHIPEP family; Region: FHIPEP; pfam00771 568707005675 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 568707005676 Type III secretion needle MxiH like; Region: MxiH; pfam09392 568707005677 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 568707005678 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707005679 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707005680 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568707005681 putative effector binding pocket; other site 568707005682 dimerization interface [polypeptide binding]; other site 568707005683 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568707005684 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 568707005685 FMN binding site [chemical binding]; other site 568707005686 active site 568707005687 substrate binding site [chemical binding]; other site 568707005688 catalytic residue [active] 568707005689 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568707005690 homotrimer interaction site [polypeptide binding]; other site 568707005691 putative active site [active] 568707005692 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568707005693 homotrimer interaction site [polypeptide binding]; other site 568707005694 putative active site [active] 568707005695 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568707005696 homotrimer interaction site [polypeptide binding]; other site 568707005697 putative active site [active] 568707005698 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707005699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707005700 DNA-binding site [nucleotide binding]; DNA binding site 568707005701 FCD domain; Region: FCD; pfam07729 568707005702 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707005703 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 568707005704 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 568707005705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707005706 NAD(P) binding site [chemical binding]; other site 568707005707 active site 568707005708 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707005709 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707005710 Walker A/P-loop; other site 568707005711 ATP binding site [chemical binding]; other site 568707005712 Q-loop/lid; other site 568707005713 ABC transporter signature motif; other site 568707005714 Walker B; other site 568707005715 D-loop; other site 568707005716 H-loop/switch region; other site 568707005717 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707005718 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707005719 Walker A/P-loop; other site 568707005720 ATP binding site [chemical binding]; other site 568707005721 Q-loop/lid; other site 568707005722 ABC transporter signature motif; other site 568707005723 Walker B; other site 568707005724 D-loop; other site 568707005725 H-loop/switch region; other site 568707005726 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707005727 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707005728 TM-ABC transporter signature motif; other site 568707005729 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707005730 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707005731 TM-ABC transporter signature motif; other site 568707005732 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707005733 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 568707005734 putative ligand binding site [chemical binding]; other site 568707005735 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 568707005736 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 568707005737 iron-sulfur cluster [ion binding]; other site 568707005738 [2Fe-2S] cluster binding site [ion binding]; other site 568707005739 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 568707005740 putative alpha subunit interface [polypeptide binding]; other site 568707005741 putative active site [active] 568707005742 putative substrate binding site [chemical binding]; other site 568707005743 Fe binding site [ion binding]; other site 568707005744 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 568707005745 Cupin domain; Region: Cupin_2; pfam07883 568707005746 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 568707005747 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 568707005748 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568707005749 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568707005750 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 568707005751 [2Fe-2S] cluster binding site [ion binding]; other site 568707005752 EamA-like transporter family; Region: EamA; pfam00892 568707005753 EamA-like transporter family; Region: EamA; pfam00892 568707005754 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707005755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707005756 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568707005757 putative effector binding pocket; other site 568707005758 dimerization interface [polypeptide binding]; other site 568707005759 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 568707005760 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 568707005761 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 568707005762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707005763 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707005764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707005765 DctM-like transporters; Region: DctM; pfam06808 568707005766 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568707005767 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707005768 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707005769 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 568707005770 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 568707005771 CoA binding domain; Region: CoA_binding_2; pfam13380 568707005772 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 568707005773 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 568707005774 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 568707005775 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568707005776 carboxyltransferase (CT) interaction site; other site 568707005777 biotinylation site [posttranslational modification]; other site 568707005778 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 568707005779 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 568707005780 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 568707005781 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 568707005782 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568707005783 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568707005784 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568707005785 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707005786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707005787 DNA-binding site [nucleotide binding]; DNA binding site 568707005788 UTRA domain; Region: UTRA; pfam07702 568707005789 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 568707005790 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568707005791 NAD(P) binding site [chemical binding]; other site 568707005792 active site 568707005793 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 568707005794 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 568707005795 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 568707005796 active site 568707005797 catalytic residues [active] 568707005798 metal binding site [ion binding]; metal-binding site 568707005799 homodimer binding site [polypeptide binding]; other site 568707005800 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568707005801 carboxyltransferase (CT) interaction site; other site 568707005802 biotinylation site [posttranslational modification]; other site 568707005803 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 568707005804 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568707005805 aldehyde dehydrogenase family 7 member; Region: PLN02315 568707005806 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 568707005807 tetrameric interface [polypeptide binding]; other site 568707005808 NAD binding site [chemical binding]; other site 568707005809 catalytic residues [active] 568707005810 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 568707005811 dimerization interface [polypeptide binding]; other site 568707005812 substrate binding site [chemical binding]; other site 568707005813 active site 568707005814 calcium binding site [ion binding]; other site 568707005815 Flagellar regulator YcgR; Region: YcgR; pfam07317 568707005816 PilZ domain; Region: PilZ; pfam07238 568707005817 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 568707005818 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 568707005819 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568707005820 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568707005821 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 568707005822 Walker A/P-loop; other site 568707005823 ATP binding site [chemical binding]; other site 568707005824 Q-loop/lid; other site 568707005825 ABC transporter signature motif; other site 568707005826 Walker B; other site 568707005827 D-loop; other site 568707005828 H-loop/switch region; other site 568707005829 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 568707005830 putative deacylase active site [active] 568707005831 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 568707005832 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 568707005833 putative active site [active] 568707005834 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707005835 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568707005836 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707005837 TM-ABC transporter signature motif; other site 568707005838 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707005839 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707005840 TM-ABC transporter signature motif; other site 568707005841 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707005842 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707005843 Walker A/P-loop; other site 568707005844 ATP binding site [chemical binding]; other site 568707005845 Q-loop/lid; other site 568707005846 ABC transporter signature motif; other site 568707005847 Walker B; other site 568707005848 D-loop; other site 568707005849 H-loop/switch region; other site 568707005850 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707005851 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707005852 Walker A/P-loop; other site 568707005853 ATP binding site [chemical binding]; other site 568707005854 Q-loop/lid; other site 568707005855 ABC transporter signature motif; other site 568707005856 Walker B; other site 568707005857 D-loop; other site 568707005858 H-loop/switch region; other site 568707005859 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 568707005860 Predicted amidohydrolase [General function prediction only]; Region: COG0388 568707005861 putative active site [active] 568707005862 catalytic triad [active] 568707005863 putative dimer interface [polypeptide binding]; other site 568707005864 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 568707005865 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 568707005866 molybdopterin cofactor binding site [chemical binding]; other site 568707005867 substrate binding site [chemical binding]; other site 568707005868 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 568707005869 molybdopterin cofactor binding site; other site 568707005870 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707005871 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_5; cd06255 568707005872 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 568707005873 putative active site [active] 568707005874 Zn binding site [ion binding]; other site 568707005875 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 568707005876 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568707005877 homodimer interface [polypeptide binding]; other site 568707005878 substrate-cofactor binding pocket; other site 568707005879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707005880 catalytic residue [active] 568707005881 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 568707005882 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 568707005883 active site residue [active] 568707005884 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 568707005885 active site residue [active] 568707005886 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 568707005887 active site residue [active] 568707005888 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 568707005889 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707005890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707005891 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 568707005892 putative dimerization interface [polypeptide binding]; other site 568707005893 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 568707005894 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 568707005895 TrkA-C domain; Region: TrkA_C; pfam02080 568707005896 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 568707005897 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 568707005898 dimanganese center [ion binding]; other site 568707005899 short chain dehydrogenase; Provisional; Region: PRK07109 568707005900 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 568707005901 putative NAD(P) binding site [chemical binding]; other site 568707005902 active site 568707005903 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 568707005904 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 568707005905 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 568707005906 active site 568707005907 tetramer interface; other site 568707005908 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707005909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707005910 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707005911 dimerization interface [polypeptide binding]; other site 568707005912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707005913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707005914 Creatinine amidohydrolase; Region: Creatininase; pfam02633 568707005915 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 568707005916 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 568707005917 allantoate amidohydrolase; Reviewed; Region: PRK12891 568707005918 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 568707005919 active site 568707005920 metal binding site [ion binding]; metal-binding site 568707005921 dimer interface [polypeptide binding]; other site 568707005922 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 568707005923 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 568707005924 ligand binding site [chemical binding]; other site 568707005925 NAD binding site [chemical binding]; other site 568707005926 dimerization interface [polypeptide binding]; other site 568707005927 catalytic site [active] 568707005928 aspartate aminotransferase; Provisional; Region: PRK06207 568707005929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707005930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707005931 homodimer interface [polypeptide binding]; other site 568707005932 catalytic residue [active] 568707005933 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568707005934 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568707005935 Walker A/P-loop; other site 568707005936 ATP binding site [chemical binding]; other site 568707005937 Q-loop/lid; other site 568707005938 ABC transporter signature motif; other site 568707005939 Walker B; other site 568707005940 D-loop; other site 568707005941 H-loop/switch region; other site 568707005942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707005943 dimer interface [polypeptide binding]; other site 568707005944 conserved gate region; other site 568707005945 putative PBP binding loops; other site 568707005946 ABC-ATPase subunit interface; other site 568707005947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707005948 conserved gate region; other site 568707005949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707005950 putative PBP binding loops; other site 568707005951 dimer interface [polypeptide binding]; other site 568707005952 ABC-ATPase subunit interface; other site 568707005953 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 568707005954 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707005955 substrate binding pocket [chemical binding]; other site 568707005956 membrane-bound complex binding site; other site 568707005957 hinge residues; other site 568707005958 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 568707005959 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 568707005960 metal binding site [ion binding]; metal-binding site 568707005961 putative dimer interface [polypeptide binding]; other site 568707005962 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 568707005963 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 568707005964 catalytic residue [active] 568707005965 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568707005966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707005967 putative DNA binding site [nucleotide binding]; other site 568707005968 putative Zn2+ binding site [ion binding]; other site 568707005969 AsnC family; Region: AsnC_trans_reg; pfam01037 568707005970 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707005971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707005972 DNA-binding site [nucleotide binding]; DNA binding site 568707005973 FCD domain; Region: FCD; pfam07729 568707005974 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568707005975 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568707005976 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 568707005977 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707005978 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 568707005979 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 568707005980 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 568707005981 DctM-like transporters; Region: DctM; pfam06808 568707005982 short chain dehydrogenase; Provisional; Region: PRK12829 568707005983 classical (c) SDRs; Region: SDR_c; cd05233 568707005984 NAD(P) binding site [chemical binding]; other site 568707005985 active site 568707005986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707005987 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568707005988 NAD(P) binding site [chemical binding]; other site 568707005989 active site 568707005990 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 568707005991 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568707005992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707005993 DNA-binding site [nucleotide binding]; DNA binding site 568707005994 FCD domain; Region: FCD; pfam07729 568707005995 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 568707005996 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568707005997 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568707005998 Amidase; Region: Amidase; cl11426 568707005999 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707006000 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707006001 Walker A/P-loop; other site 568707006002 ATP binding site [chemical binding]; other site 568707006003 Q-loop/lid; other site 568707006004 ABC transporter signature motif; other site 568707006005 Walker B; other site 568707006006 D-loop; other site 568707006007 H-loop/switch region; other site 568707006008 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707006009 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707006010 Walker A/P-loop; other site 568707006011 ATP binding site [chemical binding]; other site 568707006012 Q-loop/lid; other site 568707006013 ABC transporter signature motif; other site 568707006014 Walker B; other site 568707006015 D-loop; other site 568707006016 H-loop/switch region; other site 568707006017 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707006018 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707006019 TM-ABC transporter signature motif; other site 568707006020 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707006021 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707006022 TM-ABC transporter signature motif; other site 568707006023 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568707006024 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 568707006025 ligand binding site [chemical binding]; other site 568707006026 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568707006027 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707006028 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707006029 enoyl-CoA hydratase; Provisional; Region: PRK06144 568707006030 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707006031 substrate binding site [chemical binding]; other site 568707006032 oxyanion hole (OAH) forming residues; other site 568707006033 trimer interface [polypeptide binding]; other site 568707006034 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 568707006035 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568707006036 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568707006037 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 568707006038 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 568707006039 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568707006040 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707006041 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568707006042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707006043 NAD(P) binding site [chemical binding]; other site 568707006044 active site 568707006046 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 568707006047 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568707006048 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 568707006049 putative ligand binding site [chemical binding]; other site 568707006050 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707006051 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707006052 TM-ABC transporter signature motif; other site 568707006053 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707006054 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707006055 TM-ABC transporter signature motif; other site 568707006056 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707006057 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707006058 Walker A/P-loop; other site 568707006059 ATP binding site [chemical binding]; other site 568707006060 Q-loop/lid; other site 568707006061 ABC transporter signature motif; other site 568707006062 Walker B; other site 568707006063 D-loop; other site 568707006064 H-loop/switch region; other site 568707006065 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707006066 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707006067 Walker A/P-loop; other site 568707006068 ATP binding site [chemical binding]; other site 568707006069 Q-loop/lid; other site 568707006070 ABC transporter signature motif; other site 568707006071 Walker B; other site 568707006072 D-loop; other site 568707006073 H-loop/switch region; other site 568707006074 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707006075 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 568707006076 putative ligand binding site [chemical binding]; other site 568707006077 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707006078 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707006079 TM-ABC transporter signature motif; other site 568707006080 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707006081 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707006082 TM-ABC transporter signature motif; other site 568707006083 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707006084 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707006085 Walker A/P-loop; other site 568707006086 ATP binding site [chemical binding]; other site 568707006087 Q-loop/lid; other site 568707006088 ABC transporter signature motif; other site 568707006089 Walker B; other site 568707006090 D-loop; other site 568707006091 H-loop/switch region; other site 568707006092 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707006093 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707006094 Walker A/P-loop; other site 568707006095 ATP binding site [chemical binding]; other site 568707006096 Q-loop/lid; other site 568707006097 ABC transporter signature motif; other site 568707006098 Walker B; other site 568707006099 D-loop; other site 568707006100 H-loop/switch region; other site 568707006101 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 568707006102 Cupin domain; Region: Cupin_2; pfam07883 568707006103 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 568707006104 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 568707006105 dimer interface [polypeptide binding]; other site 568707006106 NADP binding site [chemical binding]; other site 568707006107 catalytic residues [active] 568707006108 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 568707006109 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 568707006110 putative active site [active] 568707006111 metal binding site [ion binding]; metal-binding site 568707006112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707006113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707006114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707006115 dimerization interface [polypeptide binding]; other site 568707006116 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 568707006117 active site clefts [active] 568707006118 zinc binding site [ion binding]; other site 568707006119 dimer interface [polypeptide binding]; other site 568707006120 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 568707006121 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 568707006122 Cytochrome c; Region: Cytochrom_C; pfam00034 568707006123 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 568707006124 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 568707006125 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 568707006126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707006127 non-specific DNA binding site [nucleotide binding]; other site 568707006128 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 568707006129 salt bridge; other site 568707006130 sequence-specific DNA binding site [nucleotide binding]; other site 568707006131 Cupin domain; Region: Cupin_2; pfam07883 568707006132 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 568707006133 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568707006134 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 568707006135 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707006136 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 568707006137 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568707006138 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 568707006139 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 568707006140 Walker A/P-loop; other site 568707006141 ATP binding site [chemical binding]; other site 568707006142 Q-loop/lid; other site 568707006143 ABC transporter signature motif; other site 568707006144 Walker B; other site 568707006145 D-loop; other site 568707006146 H-loop/switch region; other site 568707006147 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 568707006148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707006149 dimer interface [polypeptide binding]; other site 568707006150 conserved gate region; other site 568707006151 putative PBP binding loops; other site 568707006152 ABC-ATPase subunit interface; other site 568707006153 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 568707006154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707006155 dimer interface [polypeptide binding]; other site 568707006156 conserved gate region; other site 568707006157 putative PBP binding loops; other site 568707006158 ABC-ATPase subunit interface; other site 568707006159 PBP superfamily domain; Region: PBP_like_2; cl17296 568707006160 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 568707006161 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 568707006162 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 568707006163 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 568707006164 putative active site [active] 568707006165 catalytic site [active] 568707006166 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 568707006167 putative domain interface [polypeptide binding]; other site 568707006168 putative active site [active] 568707006169 catalytic site [active] 568707006170 exopolyphosphatase; Region: exo_poly_only; TIGR03706 568707006171 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 568707006172 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 568707006173 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 568707006174 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 568707006175 active site 568707006176 substrate binding site [chemical binding]; other site 568707006177 metal binding site [ion binding]; metal-binding site 568707006178 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 568707006179 dihydropteroate synthase; Region: DHPS; TIGR01496 568707006180 substrate binding pocket [chemical binding]; other site 568707006181 dimer interface [polypeptide binding]; other site 568707006182 inhibitor binding site; inhibition site 568707006183 FtsH Extracellular; Region: FtsH_ext; pfam06480 568707006184 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 568707006185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707006186 Walker A motif; other site 568707006187 ATP binding site [chemical binding]; other site 568707006188 Walker B motif; other site 568707006189 arginine finger; other site 568707006190 Peptidase family M41; Region: Peptidase_M41; pfam01434 568707006191 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 568707006192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707006193 S-adenosylmethionine binding site [chemical binding]; other site 568707006194 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 568707006195 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 568707006196 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 568707006197 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568707006198 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707006199 dimerization interface [polypeptide binding]; other site 568707006200 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568707006201 dimer interface [polypeptide binding]; other site 568707006202 putative CheW interface [polypeptide binding]; other site 568707006203 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 568707006204 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568707006205 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 568707006206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707006207 dimer interface [polypeptide binding]; other site 568707006208 conserved gate region; other site 568707006209 putative PBP binding loops; other site 568707006210 ABC-ATPase subunit interface; other site 568707006211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707006212 dimer interface [polypeptide binding]; other site 568707006213 conserved gate region; other site 568707006214 putative PBP binding loops; other site 568707006215 ABC-ATPase subunit interface; other site 568707006216 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568707006217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707006218 Walker A/P-loop; other site 568707006219 ATP binding site [chemical binding]; other site 568707006220 Q-loop/lid; other site 568707006221 ABC transporter signature motif; other site 568707006222 Walker B; other site 568707006223 D-loop; other site 568707006224 H-loop/switch region; other site 568707006225 TOBE domain; Region: TOBE_2; pfam08402 568707006226 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707006227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707006228 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707006229 dimerization interface [polypeptide binding]; other site 568707006230 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568707006231 catalytic core [active] 568707006232 short chain dehydrogenase; Provisional; Region: PRK07024 568707006233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707006234 NAD(P) binding site [chemical binding]; other site 568707006235 active site 568707006236 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 568707006237 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568707006238 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568707006239 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 568707006240 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568707006241 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568707006242 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 568707006243 IMP binding site; other site 568707006244 dimer interface [polypeptide binding]; other site 568707006245 interdomain contacts; other site 568707006246 partial ornithine binding site; other site 568707006247 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 568707006248 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 568707006249 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 568707006250 catalytic site [active] 568707006251 subunit interface [polypeptide binding]; other site 568707006252 transaldolase-like protein; Provisional; Region: PTZ00411 568707006253 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 568707006254 active site 568707006255 dimer interface [polypeptide binding]; other site 568707006256 catalytic residue [active] 568707006257 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707006258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707006259 dimer interface [polypeptide binding]; other site 568707006260 conserved gate region; other site 568707006261 putative PBP binding loops; other site 568707006262 ABC-ATPase subunit interface; other site 568707006263 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707006264 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707006265 Walker A/P-loop; other site 568707006266 ATP binding site [chemical binding]; other site 568707006267 Q-loop/lid; other site 568707006268 ABC transporter signature motif; other site 568707006269 Walker B; other site 568707006270 D-loop; other site 568707006271 H-loop/switch region; other site 568707006272 NMT1-like family; Region: NMT1_2; pfam13379 568707006273 NMT1/THI5 like; Region: NMT1; pfam09084 568707006274 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707006275 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707006276 recombination protein RecR; Reviewed; Region: recR; PRK00076 568707006277 RecR protein; Region: RecR; pfam02132 568707006278 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 568707006279 putative active site [active] 568707006280 putative metal-binding site [ion binding]; other site 568707006281 tetramer interface [polypeptide binding]; other site 568707006282 hypothetical protein; Validated; Region: PRK00153 568707006283 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 568707006284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707006285 Walker A motif; other site 568707006286 ATP binding site [chemical binding]; other site 568707006287 Walker B motif; other site 568707006288 arginine finger; other site 568707006289 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 568707006290 Part of AAA domain; Region: AAA_19; pfam13245 568707006291 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 568707006292 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 568707006293 probable DNA repair protein; Region: TIGR03623 568707006294 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 568707006295 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 568707006296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707006297 putative substrate translocation pore; other site 568707006298 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 568707006299 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 568707006300 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 568707006301 intracellular protease, PfpI family; Region: PfpI; TIGR01382 568707006302 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 568707006303 conserved cys residue [active] 568707006304 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 568707006305 putative deacylase active site [active] 568707006306 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 568707006307 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568707006308 active site 568707006309 DNA binding site [nucleotide binding] 568707006310 Int/Topo IB signature motif; other site 568707006311 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568707006312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707006313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707006314 dimerization interface [polypeptide binding]; other site 568707006315 thiamine pyrophosphate protein; Validated; Region: PRK08199 568707006316 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707006317 PYR/PP interface [polypeptide binding]; other site 568707006318 dimer interface [polypeptide binding]; other site 568707006319 TPP binding site [chemical binding]; other site 568707006320 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707006321 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 568707006322 TPP-binding site [chemical binding]; other site 568707006323 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 568707006324 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707006325 FAD binding site [chemical binding]; other site 568707006326 substrate binding pocket [chemical binding]; other site 568707006327 catalytic base [active] 568707006328 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 568707006329 putative active site [active] 568707006330 putative catalytic site [active] 568707006331 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707006332 PYR/PP interface [polypeptide binding]; other site 568707006333 dimer interface [polypeptide binding]; other site 568707006334 TPP binding site [chemical binding]; other site 568707006335 hypothetical protein; Validated; Region: PRK07586 568707006336 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 568707006337 TPP-binding site [chemical binding]; other site 568707006338 dimer interface [polypeptide binding]; other site 568707006339 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568707006340 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568707006341 Walker A/P-loop; other site 568707006342 ATP binding site [chemical binding]; other site 568707006343 Q-loop/lid; other site 568707006344 ABC transporter signature motif; other site 568707006345 Walker B; other site 568707006346 D-loop; other site 568707006347 H-loop/switch region; other site 568707006348 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568707006349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707006350 dimer interface [polypeptide binding]; other site 568707006351 conserved gate region; other site 568707006352 putative PBP binding loops; other site 568707006353 ABC-ATPase subunit interface; other site 568707006354 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707006355 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568707006356 substrate binding pocket [chemical binding]; other site 568707006357 membrane-bound complex binding site; other site 568707006358 hinge residues; other site 568707006359 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 568707006360 agmatinase; Region: agmatinase; TIGR01230 568707006361 oligomer interface [polypeptide binding]; other site 568707006362 putative active site [active] 568707006363 Mn binding site [ion binding]; other site 568707006364 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707006365 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707006366 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707006367 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 568707006368 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707006369 substrate binding pocket [chemical binding]; other site 568707006370 membrane-bound complex binding site; other site 568707006371 hinge residues; other site 568707006372 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 568707006373 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 568707006374 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 568707006375 ATP-grasp domain; Region: ATP-grasp; pfam02222 568707006376 AIR carboxylase; Region: AIRC; pfam00731 568707006377 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 568707006378 toxin interface [polypeptide binding]; other site 568707006379 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 568707006380 Zn binding site [ion binding]; other site 568707006381 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 568707006382 non-specific DNA binding site [nucleotide binding]; other site 568707006383 salt bridge; other site 568707006384 sequence-specific DNA binding site [nucleotide binding]; other site 568707006385 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 568707006386 peptide binding site [polypeptide binding]; other site 568707006387 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 568707006388 ATP binding site [chemical binding]; other site 568707006389 active site 568707006390 substrate binding site [chemical binding]; other site 568707006391 Uncharacterized conserved protein [Function unknown]; Region: COG3791 568707006392 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 568707006393 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 568707006394 intersubunit interface [polypeptide binding]; other site 568707006395 active site 568707006396 zinc binding site [ion binding]; other site 568707006397 Na+ binding site [ion binding]; other site 568707006398 MOSC domain; Region: MOSC; pfam03473 568707006399 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568707006400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707006401 DNA binding residues [nucleotide binding] 568707006402 dimerization interface [polypeptide binding]; other site 568707006403 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 568707006404 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 568707006405 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 568707006406 formate dehydrogenase; Provisional; Region: PRK07574 568707006407 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 568707006408 dimerization interface [polypeptide binding]; other site 568707006409 ligand binding site [chemical binding]; other site 568707006410 NAD binding site [chemical binding]; other site 568707006411 catalytic site [active] 568707006412 Uncharacterized conserved protein [Function unknown]; Region: COG3791 568707006413 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 568707006414 rRNA binding site [nucleotide binding]; other site 568707006415 predicted 30S ribosome binding site; other site 568707006416 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 568707006417 Peptidase family M23; Region: Peptidase_M23; pfam01551 568707006418 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 568707006419 MPT binding site; other site 568707006420 trimer interface [polypeptide binding]; other site 568707006421 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 568707006422 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 568707006423 AzlC protein; Region: AzlC; pfam03591 568707006424 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 568707006425 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 568707006426 substrate binding site [polypeptide binding]; other site 568707006427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707006428 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568707006429 Coenzyme A binding pocket [chemical binding]; other site 568707006430 DinB family; Region: DinB; cl17821 568707006431 DinB superfamily; Region: DinB_2; pfam12867 568707006433 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 568707006434 phosphate acetyltransferase; Provisional; Region: PRK11890 568707006435 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 568707006436 propionate/acetate kinase; Provisional; Region: PRK12379 568707006437 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 568707006438 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 568707006439 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 568707006440 NAD binding site [chemical binding]; other site 568707006441 homotetramer interface [polypeptide binding]; other site 568707006442 homodimer interface [polypeptide binding]; other site 568707006443 substrate binding site [chemical binding]; other site 568707006444 active site 568707006445 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 568707006446 Phosphoglycerate kinase; Region: PGK; pfam00162 568707006447 substrate binding site [chemical binding]; other site 568707006448 hinge regions; other site 568707006449 ADP binding site [chemical binding]; other site 568707006450 catalytic site [active] 568707006451 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 568707006452 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 568707006453 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 568707006454 transketolase; Reviewed; Region: PRK12753 568707006455 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 568707006456 TPP-binding site [chemical binding]; other site 568707006457 dimer interface [polypeptide binding]; other site 568707006458 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568707006459 PYR/PP interface [polypeptide binding]; other site 568707006460 dimer interface [polypeptide binding]; other site 568707006461 TPP binding site [chemical binding]; other site 568707006462 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568707006463 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 568707006464 RNA methyltransferase, RsmE family; Region: TIGR00046 568707006465 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 568707006466 putative RNAase interaction site [polypeptide binding]; other site 568707006467 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 568707006468 active site 568707006469 nucleophile elbow; other site 568707006470 malic enzyme; Reviewed; Region: PRK12861 568707006471 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568707006472 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 568707006473 putative NAD(P) binding site [chemical binding]; other site 568707006474 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 568707006475 aminotransferase; Validated; Region: PRK07337 568707006476 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707006477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707006478 homodimer interface [polypeptide binding]; other site 568707006479 catalytic residue [active] 568707006480 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 568707006481 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568707006482 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568707006483 catalytic residue [active] 568707006484 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 568707006485 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 568707006486 siroheme synthase; Provisional; Region: cysG; PRK10637 568707006487 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 568707006488 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 568707006489 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 568707006490 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 568707006491 active site 568707006492 SAM binding site [chemical binding]; other site 568707006493 homodimer interface [polypeptide binding]; other site 568707006494 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 568707006495 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568707006496 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707006497 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568707006498 active site 568707006499 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 568707006500 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 568707006501 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 568707006502 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 568707006503 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 568707006504 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 568707006505 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 568707006506 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 568707006507 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 568707006508 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 568707006509 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 568707006510 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 568707006511 Protein export membrane protein; Region: SecD_SecF; pfam02355 568707006512 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 568707006513 active site 568707006514 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 568707006515 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 568707006516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568707006517 FeS/SAM binding site; other site 568707006518 TRAM domain; Region: TRAM; pfam01938 568707006519 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 568707006520 PhoH-like protein; Region: PhoH; pfam02562 568707006521 metal-binding heat shock protein; Provisional; Region: PRK00016 568707006522 FOG: CBS domain [General function prediction only]; Region: COG0517 568707006523 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568707006524 Transporter associated domain; Region: CorC_HlyC; smart01091 568707006525 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 568707006526 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 568707006527 putative active site [active] 568707006528 catalytic triad [active] 568707006529 putative dimer interface [polypeptide binding]; other site 568707006530 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568707006531 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568707006532 active site 568707006533 catalytic tetrad [active] 568707006534 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707006535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707006536 DNA-binding site [nucleotide binding]; DNA binding site 568707006537 FCD domain; Region: FCD; pfam07729 568707006538 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 568707006539 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707006540 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 568707006541 L-aspartate oxidase; Provisional; Region: PRK06175 568707006542 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 568707006543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707006544 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 568707006545 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568707006546 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 568707006547 Isochorismatase family; Region: Isochorismatase; pfam00857 568707006548 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 568707006549 catalytic triad [active] 568707006550 conserved cis-peptide bond; other site 568707006551 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568707006552 phenylhydantoinase; Validated; Region: PRK08323 568707006553 Cyclic amidohydrolases, including hydantoinase, dihydropyrimidinase, allantoinase, and dihydroorotase, are involved in the metabolism of pyrimidines and purines, sharing the property of hydrolyzing the cyclic amide bond of each substrate to the...; Region: Cyclic_amidohydrolases; cd01302 568707006554 active site 568707006555 tetramer interface [polypeptide binding]; other site 568707006556 aconitate hydratase; Validated; Region: PRK09277 568707006557 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 568707006558 substrate binding site [chemical binding]; other site 568707006559 ligand binding site [chemical binding]; other site 568707006560 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 568707006561 substrate binding site [chemical binding]; other site 568707006562 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 568707006563 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 568707006564 tetramer interface [polypeptide binding]; other site 568707006565 active site 568707006566 Mg2+/Mn2+ binding site [ion binding]; other site 568707006567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707006568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707006569 biotin synthase; Region: bioB; TIGR00433 568707006570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568707006571 FeS/SAM binding site; other site 568707006572 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 568707006573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707006574 putative MFS family transporter protein; Provisional; Region: PRK03633 568707006575 putative substrate translocation pore; other site 568707006576 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 568707006577 catalytic triad [active] 568707006578 dimer interface [polypeptide binding]; other site 568707006579 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 568707006580 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 568707006581 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 568707006582 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 568707006583 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 568707006584 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 568707006585 ligand binding site [chemical binding]; other site 568707006586 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 568707006587 trimer interface [polypeptide binding]; other site 568707006588 dimer interface [polypeptide binding]; other site 568707006589 putative active site [active] 568707006590 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 568707006591 MoaE interaction surface [polypeptide binding]; other site 568707006592 MoeB interaction surface [polypeptide binding]; other site 568707006593 thiocarboxylated glycine; other site 568707006594 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 568707006595 MoaE homodimer interface [polypeptide binding]; other site 568707006596 MoaD interaction [polypeptide binding]; other site 568707006597 active site residues [active] 568707006598 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 568707006599 MPT binding site; other site 568707006600 trimer interface [polypeptide binding]; other site 568707006601 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 568707006602 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 568707006603 dimer interface [polypeptide binding]; other site 568707006604 putative functional site; other site 568707006605 putative MPT binding site; other site 568707006606 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 568707006607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568707006608 FeS/SAM binding site; other site 568707006609 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 568707006610 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 568707006611 PBP superfamily domain; Region: PBP_like; pfam12727 568707006612 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 568707006613 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 568707006614 putative dimer interface [polypeptide binding]; other site 568707006615 [2Fe-2S] cluster binding site [ion binding]; other site 568707006616 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 568707006617 putative dimer interface [polypeptide binding]; other site 568707006618 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 568707006619 SLBB domain; Region: SLBB; pfam10531 568707006620 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 568707006621 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 568707006622 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707006623 catalytic loop [active] 568707006624 iron binding site [ion binding]; other site 568707006625 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 568707006626 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 568707006627 [4Fe-4S] binding site [ion binding]; other site 568707006628 molybdopterin cofactor binding site; other site 568707006629 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 568707006630 molybdopterin cofactor binding site; other site 568707006631 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 568707006632 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 568707006633 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 568707006634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707006635 S-adenosylmethionine binding site [chemical binding]; other site 568707006636 Chromate transporter; Region: Chromate_transp; pfam02417 568707006637 Chromate transporter; Region: Chromate_transp; pfam02417 568707006638 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568707006639 Ligand Binding Site [chemical binding]; other site 568707006640 threonine and homoserine efflux system; Provisional; Region: PRK10532 568707006641 EamA-like transporter family; Region: EamA; pfam00892 568707006642 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 568707006643 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 568707006644 tetramer interface [polypeptide binding]; other site 568707006645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707006646 catalytic residue [active] 568707006647 metabolite-proton symporter; Region: 2A0106; TIGR00883 568707006648 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 568707006649 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 568707006650 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 568707006651 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 568707006652 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 568707006653 D-pathway; other site 568707006654 Putative ubiquinol binding site [chemical binding]; other site 568707006655 Low-spin heme (heme b) binding site [chemical binding]; other site 568707006656 Putative water exit pathway; other site 568707006657 Binuclear center (heme o3/CuB) [ion binding]; other site 568707006658 K-pathway; other site 568707006659 Putative proton exit pathway; other site 568707006660 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 568707006661 Subunit I/III interface [polypeptide binding]; other site 568707006662 Subunit III/IV interface [polypeptide binding]; other site 568707006663 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 568707006664 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 568707006665 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 568707006666 putative NAD(P) binding site [chemical binding]; other site 568707006667 putative active site [active] 568707006668 N-formylglutamate amidohydrolase; Region: FGase; cl01522 568707006669 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 568707006670 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 568707006671 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707006672 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 568707006673 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 568707006674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 568707006675 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 568707006676 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 568707006677 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568707006678 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568707006679 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 568707006680 Peptidase family M23; Region: Peptidase_M23; pfam01551 568707006681 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 568707006682 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 568707006683 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 568707006684 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 568707006685 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707006686 N-terminal plug; other site 568707006687 ligand-binding site [chemical binding]; other site 568707006688 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 568707006689 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 568707006690 hypothetical protein; Provisional; Region: PRK05409 568707006691 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 568707006692 Predicted membrane protein [Function unknown]; Region: COG2259 568707006693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707006694 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707006695 putative substrate translocation pore; other site 568707006696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707006697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707006698 dimerization interface [polypeptide binding]; other site 568707006699 putative DNA binding site [nucleotide binding]; other site 568707006700 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 568707006701 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 568707006702 Subunit I/III interface [polypeptide binding]; other site 568707006703 Subunit III/IV interface [polypeptide binding]; other site 568707006704 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 568707006705 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 568707006706 D-pathway; other site 568707006707 Putative ubiquinol binding site [chemical binding]; other site 568707006708 Low-spin heme (heme b) binding site [chemical binding]; other site 568707006709 Putative water exit pathway; other site 568707006710 Binuclear center (heme o3/CuB) [ion binding]; other site 568707006711 K-pathway; other site 568707006712 Putative proton exit pathway; other site 568707006713 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 568707006714 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 568707006715 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 568707006716 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 568707006717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707006718 active site 568707006719 phosphorylation site [posttranslational modification] 568707006720 intermolecular recognition site; other site 568707006721 dimerization interface [polypeptide binding]; other site 568707006722 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 568707006723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568707006724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707006725 ATP binding site [chemical binding]; other site 568707006726 G-X-G motif; other site 568707006727 Methyltransferase domain; Region: Methyltransf_31; pfam13847 568707006728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707006729 Pirin-related protein [General function prediction only]; Region: COG1741 568707006730 Pirin; Region: Pirin; pfam02678 568707006731 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 568707006732 HutD; Region: HutD; pfam05962 568707006733 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707006734 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707006735 LysR substrate binding domain; Region: LysR_substrate; pfam03466 568707006736 dimerization interface [polypeptide binding]; other site 568707006737 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707006738 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707006739 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 568707006740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707006741 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 568707006742 dimerization interface [polypeptide binding]; other site 568707006743 substrate binding pocket [chemical binding]; other site 568707006744 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707006745 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707006746 active site 2 [active] 568707006747 active site 1 [active] 568707006748 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707006749 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 568707006750 active site 568707006751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707006752 putative DNA binding site [nucleotide binding]; other site 568707006753 putative Zn2+ binding site [ion binding]; other site 568707006754 threonine dehydratase; Reviewed; Region: PRK09224 568707006755 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 568707006756 tetramer interface [polypeptide binding]; other site 568707006757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707006758 catalytic residue [active] 568707006759 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 568707006760 putative Ile/Val binding site [chemical binding]; other site 568707006761 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 568707006762 putative Ile/Val binding site [chemical binding]; other site 568707006763 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 568707006764 SlyX; Region: SlyX; pfam04102 568707006765 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 568707006766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 568707006767 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 568707006768 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 568707006769 active site 568707006770 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568707006771 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 568707006772 Helix-turn-helix domain; Region: HTH_18; pfam12833 568707006773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707006774 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568707006775 EamA-like transporter family; Region: EamA; pfam00892 568707006776 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 568707006777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707006778 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707006779 dimerization interface [polypeptide binding]; other site 568707006780 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 568707006781 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 568707006782 FMN binding site [chemical binding]; other site 568707006783 substrate binding site [chemical binding]; other site 568707006784 putative catalytic residue [active] 568707006785 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707006786 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707006787 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 568707006788 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 568707006789 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707006790 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 568707006791 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 568707006792 active site 568707006793 purine riboside binding site [chemical binding]; other site 568707006794 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 568707006795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707006796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707006797 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 568707006798 putative dimerization interface [polypeptide binding]; other site 568707006799 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568707006800 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 568707006801 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 568707006802 putative dimer interface [polypeptide binding]; other site 568707006803 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 568707006804 Found in ATP-dependent protease La (LON); Region: LON; smart00464 568707006805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707006806 Walker A motif; other site 568707006807 ATP binding site [chemical binding]; other site 568707006808 Walker B motif; other site 568707006809 arginine finger; other site 568707006810 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 568707006811 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 568707006812 EF-hand domain pair; Region: EF_hand_5; pfam13499 568707006813 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 568707006814 Ca2+ binding site [ion binding]; other site 568707006815 tetrathionate reductase subunit B; Provisional; Region: PRK14993 568707006816 4Fe-4S binding domain; Region: Fer4; pfam00037 568707006817 tetrathionate reductase subunit C; Provisional; Region: PRK14992 568707006818 tetrathionate reductase subunit A; Provisional; Region: PRK14991 568707006819 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568707006820 molybdopterin cofactor binding site; other site 568707006821 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 568707006822 putative molybdopterin cofactor binding site [chemical binding]; other site 568707006823 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 568707006824 putative molybdopterin cofactor binding site; other site 568707006825 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 568707006826 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707006827 DNA-binding site [nucleotide binding]; DNA binding site 568707006828 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707006829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707006830 homodimer interface [polypeptide binding]; other site 568707006831 catalytic residue [active] 568707006832 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 568707006833 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 568707006834 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 568707006835 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 568707006836 putative active site [active] 568707006837 putative metal binding site [ion binding]; other site 568707006838 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 568707006839 putative dimer interface [polypeptide binding]; other site 568707006840 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568707006841 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568707006842 endonuclease III; Region: ENDO3c; smart00478 568707006843 minor groove reading motif; other site 568707006844 helix-hairpin-helix signature motif; other site 568707006845 substrate binding pocket [chemical binding]; other site 568707006846 active site 568707006847 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 568707006848 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 568707006849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707006850 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 568707006851 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 568707006852 DNA binding site [nucleotide binding] 568707006853 active site 568707006855 Hemerythrin-like domain; Region: Hr-like; cd12108 568707006856 Fe binding site [ion binding]; other site 568707006857 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 568707006858 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 568707006859 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 568707006860 putative catalytic residue [active] 568707006861 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707006862 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 568707006863 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 568707006864 DctM-like transporters; Region: DctM; pfam06808 568707006865 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568707006866 putative amidase; Provisional; Region: PRK06169 568707006867 Amidase; Region: Amidase; cl11426 568707006868 aminoglycoside resistance protein; Provisional; Region: PRK13746 568707006869 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 568707006870 active site 568707006871 NTP binding site [chemical binding]; other site 568707006872 metal binding triad [ion binding]; metal-binding site 568707006873 antibiotic binding site [chemical binding]; other site 568707006874 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 568707006875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707006876 Coenzyme A binding pocket [chemical binding]; other site 568707006877 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707006878 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707006879 metal binding site [ion binding]; metal-binding site 568707006880 active site 568707006881 I-site; other site 568707006882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707006883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707006884 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 568707006885 putative dimerization interface [polypeptide binding]; other site 568707006886 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707006887 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707006888 substrate binding site [chemical binding]; other site 568707006889 oxyanion hole (OAH) forming residues; other site 568707006890 trimer interface [polypeptide binding]; other site 568707006891 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707006892 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707006893 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 568707006894 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707006895 NAD(P) binding site [chemical binding]; other site 568707006896 catalytic residues [active] 568707006897 hypothetical protein; Provisional; Region: PRK07064 568707006898 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707006899 PYR/PP interface [polypeptide binding]; other site 568707006900 dimer interface [polypeptide binding]; other site 568707006901 TPP binding site [chemical binding]; other site 568707006902 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707006903 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 568707006904 TPP-binding site [chemical binding]; other site 568707006905 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707006906 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 568707006907 Uncharacterized conserved protein [Function unknown]; Region: COG2128 568707006908 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 568707006909 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707006910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707006911 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 568707006912 putative effector binding pocket; other site 568707006913 putative dimerization interface [polypeptide binding]; other site 568707006914 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 568707006915 dimer interface [polypeptide binding]; other site 568707006916 putative CheW interface [polypeptide binding]; other site 568707006917 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 568707006918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707006919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707006920 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568707006921 putative effector binding pocket; other site 568707006922 dimerization interface [polypeptide binding]; other site 568707006923 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 568707006924 NADP binding site [chemical binding]; other site 568707006925 active site 568707006926 regulatory binding site [polypeptide binding]; other site 568707006927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707006928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707006929 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 568707006930 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 568707006931 classical (c) SDRs; Region: SDR_c; cd05233 568707006932 NAD(P) binding site [chemical binding]; other site 568707006933 active site 568707006934 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707006935 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707006936 active site 568707006937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707006938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707006939 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707006940 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707006941 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707006942 arsenical pump membrane protein; Provisional; Region: PRK15445 568707006943 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 568707006944 transmembrane helices; other site 568707006945 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707006946 putative DNA binding site [nucleotide binding]; other site 568707006947 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 568707006948 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 568707006949 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 568707006950 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 568707006951 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568707006952 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 568707006953 Walker A/P-loop; other site 568707006954 ATP binding site [chemical binding]; other site 568707006955 Q-loop/lid; other site 568707006956 ABC transporter signature motif; other site 568707006957 Walker B; other site 568707006958 D-loop; other site 568707006959 H-loop/switch region; other site 568707006960 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 568707006961 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568707006962 HlyD family secretion protein; Region: HlyD_3; pfam13437 568707006963 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568707006964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707006965 DNA binding residues [nucleotide binding] 568707006966 dimerization interface [polypeptide binding]; other site 568707006967 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 568707006968 Putative Ig domain; Region: He_PIG; pfam05345 568707006969 VCBS repeat; Region: VCBS_repeat; TIGR01965 568707006970 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 568707006971 Putative Ig domain; Region: He_PIG; pfam05345 568707006972 VCBS repeat; Region: VCBS_repeat; TIGR01965 568707006973 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 568707006974 Putative Ig domain; Region: He_PIG; pfam05345 568707006975 VCBS repeat; Region: VCBS_repeat; TIGR01965 568707006976 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 568707006977 Putative Ig domain; Region: He_PIG; pfam05345 568707006978 VCBS repeat; Region: VCBS_repeat; TIGR01965 568707006979 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 568707006980 Putative Ig domain; Region: He_PIG; pfam05345 568707006981 VCBS repeat; Region: VCBS_repeat; TIGR01965 568707006982 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 568707006983 Putative Ig domain; Region: He_PIG; pfam05345 568707006984 VCBS repeat; Region: VCBS_repeat; TIGR01965 568707006985 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 568707006986 Putative Ig domain; Region: He_PIG; pfam05345 568707006987 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 568707006988 metal ion-dependent adhesion site (MIDAS); other site 568707006989 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 568707006990 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 568707006991 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 568707006992 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707006993 metal binding site [ion binding]; metal-binding site 568707006994 active site 568707006995 I-site; other site 568707006996 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 568707006997 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 568707006998 Isochorismatase family; Region: Isochorismatase; pfam00857 568707006999 catalytic triad [active] 568707007000 dimer interface [polypeptide binding]; other site 568707007001 conserved cis-peptide bond; other site 568707007002 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 568707007003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707007004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707007005 homodimer interface [polypeptide binding]; other site 568707007006 catalytic residue [active] 568707007007 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 568707007008 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568707007009 Zn2+ binding site [ion binding]; other site 568707007010 Mg2+ binding site [ion binding]; other site 568707007011 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568707007012 metal-binding site [ion binding] 568707007013 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568707007014 metal-binding site [ion binding] 568707007015 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 568707007016 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568707007017 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568707007018 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 568707007019 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 568707007020 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 568707007021 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 568707007022 NAD(P) binding site [chemical binding]; other site 568707007023 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568707007024 CoenzymeA binding site [chemical binding]; other site 568707007025 subunit interaction site [polypeptide binding]; other site 568707007026 PHB binding site; other site 568707007027 NMT1/THI5 like; Region: NMT1; pfam09084 568707007028 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707007029 substrate binding pocket [chemical binding]; other site 568707007030 membrane-bound complex binding site; other site 568707007031 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707007032 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707007033 Walker A/P-loop; other site 568707007034 ATP binding site [chemical binding]; other site 568707007035 Q-loop/lid; other site 568707007036 ABC transporter signature motif; other site 568707007037 Walker B; other site 568707007038 D-loop; other site 568707007039 H-loop/switch region; other site 568707007040 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707007041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007042 dimer interface [polypeptide binding]; other site 568707007043 conserved gate region; other site 568707007044 putative PBP binding loops; other site 568707007045 ABC-ATPase subunit interface; other site 568707007046 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 568707007047 putative active site [active] 568707007048 Zn binding site [ion binding]; other site 568707007049 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 568707007050 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707007051 acyl-activating enzyme (AAE) consensus motif; other site 568707007052 AMP binding site [chemical binding]; other site 568707007053 active site 568707007054 CoA binding site [chemical binding]; other site 568707007055 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 568707007056 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568707007057 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707007058 putative DNA binding site [nucleotide binding]; other site 568707007059 putative Zn2+ binding site [ion binding]; other site 568707007060 AsnC family; Region: AsnC_trans_reg; pfam01037 568707007061 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007062 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 568707007063 Lumazine binding domain; Region: Lum_binding; pfam00677 568707007064 Lumazine binding domain; Region: Lum_binding; pfam00677 568707007065 putative cyanate transporter; Provisional; Region: cynX; PRK09705 568707007066 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 568707007067 nucleoside/Zn binding site; other site 568707007068 dimer interface [polypeptide binding]; other site 568707007069 catalytic motif [active] 568707007070 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 568707007071 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 568707007072 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 568707007073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007074 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707007075 dimerization interface [polypeptide binding]; other site 568707007076 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568707007077 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 568707007078 active site 568707007079 FMN binding site [chemical binding]; other site 568707007080 substrate binding site [chemical binding]; other site 568707007081 homotetramer interface [polypeptide binding]; other site 568707007082 catalytic residue [active] 568707007083 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707007084 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707007085 Walker A/P-loop; other site 568707007086 ATP binding site [chemical binding]; other site 568707007087 Q-loop/lid; other site 568707007088 ABC transporter signature motif; other site 568707007089 Walker B; other site 568707007090 D-loop; other site 568707007091 H-loop/switch region; other site 568707007092 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707007093 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707007094 Walker A/P-loop; other site 568707007095 ATP binding site [chemical binding]; other site 568707007096 Q-loop/lid; other site 568707007097 ABC transporter signature motif; other site 568707007098 Walker B; other site 568707007099 D-loop; other site 568707007100 H-loop/switch region; other site 568707007101 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707007102 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707007103 TM-ABC transporter signature motif; other site 568707007104 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707007105 TM-ABC transporter signature motif; other site 568707007106 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 568707007107 homotrimer interaction site [polypeptide binding]; other site 568707007108 putative active site [active] 568707007109 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 568707007110 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707007111 acyl-activating enzyme (AAE) consensus motif; other site 568707007112 AMP binding site [chemical binding]; other site 568707007113 active site 568707007114 CoA binding site [chemical binding]; other site 568707007115 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 568707007116 active site 568707007117 catalytic site [active] 568707007118 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568707007119 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 568707007120 ligand binding site [chemical binding]; other site 568707007121 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707007122 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707007123 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707007124 short chain dehydrogenase; Provisional; Region: PRK06125 568707007125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707007126 NAD(P) binding site [chemical binding]; other site 568707007127 active site 568707007128 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 568707007129 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 568707007130 putative active site [active] 568707007131 putative catalytic site [active] 568707007132 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707007133 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707007134 Walker A/P-loop; other site 568707007135 ATP binding site [chemical binding]; other site 568707007136 Q-loop/lid; other site 568707007137 ABC transporter signature motif; other site 568707007138 Walker B; other site 568707007139 D-loop; other site 568707007140 H-loop/switch region; other site 568707007141 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707007142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007143 dimer interface [polypeptide binding]; other site 568707007144 conserved gate region; other site 568707007145 putative PBP binding loops; other site 568707007146 ABC-ATPase subunit interface; other site 568707007147 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568707007148 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568707007149 substrate binding pocket [chemical binding]; other site 568707007150 membrane-bound complex binding site; other site 568707007151 enoyl-CoA hydratase; Provisional; Region: PRK06127 568707007152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707007153 substrate binding site [chemical binding]; other site 568707007154 oxyanion hole (OAH) forming residues; other site 568707007155 trimer interface [polypeptide binding]; other site 568707007156 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707007157 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707007158 Amidase; Region: Amidase; cl11426 568707007159 Amidase; Region: Amidase; cl11426 568707007160 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568707007161 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707007162 DNA-binding site [nucleotide binding]; DNA binding site 568707007163 FCD domain; Region: FCD; pfam07729 568707007164 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568707007165 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707007166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707007167 DNA-binding site [nucleotide binding]; DNA binding site 568707007168 UTRA domain; Region: UTRA; pfam07702 568707007169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 568707007170 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 568707007171 Domain of unknown function (DUF802); Region: DUF802; pfam05650 568707007172 hypothetical protein; Provisional; Region: PRK09040 568707007173 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568707007174 ligand binding site [chemical binding]; other site 568707007175 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 568707007176 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 568707007177 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 568707007178 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 568707007179 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 568707007180 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707007181 active site 568707007182 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 568707007183 AMP-binding domain protein; Validated; Region: PRK07529 568707007184 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707007185 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 568707007186 acyl-activating enzyme (AAE) consensus motif; other site 568707007187 putative AMP binding site [chemical binding]; other site 568707007188 putative active site [active] 568707007189 putative CoA binding site [chemical binding]; other site 568707007190 enoyl-CoA hydratase; Provisional; Region: PRK08290 568707007191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707007192 substrate binding site [chemical binding]; other site 568707007193 oxyanion hole (OAH) forming residues; other site 568707007194 trimer interface [polypeptide binding]; other site 568707007195 enoyl-CoA hydratase; Provisional; Region: PRK06563 568707007196 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707007197 substrate binding site [chemical binding]; other site 568707007198 oxyanion hole (OAH) forming residues; other site 568707007199 trimer interface [polypeptide binding]; other site 568707007200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 568707007201 PAS domain; Region: PAS_9; pfam13426 568707007202 putative active site [active] 568707007203 heme pocket [chemical binding]; other site 568707007204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 568707007205 Histidine kinase; Region: HisKA_3; pfam07730 568707007206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707007207 ATP binding site [chemical binding]; other site 568707007208 Mg2+ binding site [ion binding]; other site 568707007209 G-X-G motif; other site 568707007210 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007211 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568707007212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707007213 active site 568707007214 phosphorylation site [posttranslational modification] 568707007215 intermolecular recognition site; other site 568707007216 dimerization interface [polypeptide binding]; other site 568707007217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707007218 DNA binding residues [nucleotide binding] 568707007219 dimerization interface [polypeptide binding]; other site 568707007220 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 568707007221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007222 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 568707007223 dimerization interface [polypeptide binding]; other site 568707007224 substrate binding pocket [chemical binding]; other site 568707007225 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007226 Cupin domain; Region: Cupin_2; pfam07883 568707007227 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 568707007228 Predicted amidohydrolase [General function prediction only]; Region: COG0388 568707007229 putative active site [active] 568707007230 catalytic triad [active] 568707007231 putative dimer interface [polypeptide binding]; other site 568707007232 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 568707007233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707007234 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 568707007235 classical (c) SDRs; Region: SDR_c; cd05233 568707007236 NAD(P) binding site [chemical binding]; other site 568707007237 active site 568707007238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707007239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707007241 dimerization interface [polypeptide binding]; other site 568707007242 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 568707007243 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707007244 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707007245 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 568707007246 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 568707007247 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 568707007248 phosphate binding site [ion binding]; other site 568707007249 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 568707007250 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 568707007251 dimer interface [polypeptide binding]; other site 568707007252 active site 568707007253 catalytic residue [active] 568707007254 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 568707007255 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707007256 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568707007257 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707007258 catalytic loop [active] 568707007259 iron binding site [ion binding]; other site 568707007260 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 568707007261 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 568707007262 [2Fe-2S] cluster binding site [ion binding]; other site 568707007263 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 568707007264 alpha subunit interface [polypeptide binding]; other site 568707007265 active site 568707007266 substrate binding site [chemical binding]; other site 568707007267 Fe binding site [ion binding]; other site 568707007268 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007269 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 568707007270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707007271 active site 568707007272 phosphorylation site [posttranslational modification] 568707007273 intermolecular recognition site; other site 568707007274 dimerization interface [polypeptide binding]; other site 568707007275 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707007276 dimerization interface [polypeptide binding]; other site 568707007277 DNA binding residues [nucleotide binding] 568707007278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707007279 dimer interface [polypeptide binding]; other site 568707007280 phosphorylation site [posttranslational modification] 568707007281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707007282 ATP binding site [chemical binding]; other site 568707007283 Mg2+ binding site [ion binding]; other site 568707007284 G-X-G motif; other site 568707007285 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 568707007286 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 568707007287 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568707007288 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 568707007289 Soluble P-type ATPase [General function prediction only]; Region: COG4087 568707007290 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568707007291 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707007293 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707007294 active site 568707007295 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707007296 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707007297 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 568707007298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007299 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 568707007300 putative dimerization interface [polypeptide binding]; other site 568707007301 putative substrate binding pocket [chemical binding]; other site 568707007302 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007303 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 568707007304 active site 568707007305 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 568707007306 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707007308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007309 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 568707007310 putative dimerization interface [polypeptide binding]; other site 568707007311 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707007312 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707007313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707007314 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707007315 substrate binding site [chemical binding]; other site 568707007316 oxyanion hole (OAH) forming residues; other site 568707007317 trimer interface [polypeptide binding]; other site 568707007320 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 568707007321 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 568707007322 active site 568707007323 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 568707007324 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707007326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707007327 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707007328 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707007329 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568707007330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707007331 Coenzyme A binding pocket [chemical binding]; other site 568707007332 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 568707007333 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568707007334 catalytic site [active] 568707007335 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007336 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 568707007337 Amidohydrolase; Region: Amidohydro_2; pfam04909 568707007338 active site 568707007339 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 568707007340 transcriptional regulator NanR; Provisional; Region: PRK03837 568707007341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707007342 DNA-binding site [nucleotide binding]; DNA binding site 568707007343 FCD domain; Region: FCD; pfam07729 568707007344 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568707007345 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707007346 substrate binding pocket [chemical binding]; other site 568707007347 membrane-bound complex binding site; other site 568707007348 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707007349 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707007350 Walker A/P-loop; other site 568707007351 ATP binding site [chemical binding]; other site 568707007352 Q-loop/lid; other site 568707007353 ABC transporter signature motif; other site 568707007354 Walker B; other site 568707007355 D-loop; other site 568707007356 H-loop/switch region; other site 568707007357 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707007358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007359 putative PBP binding loops; other site 568707007360 dimer interface [polypeptide binding]; other site 568707007361 ABC-ATPase subunit interface; other site 568707007362 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568707007363 choline dehydrogenase; Validated; Region: PRK02106 568707007364 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 568707007365 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707007366 Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108 568707007367 NAD(P) binding site [chemical binding]; other site 568707007368 catalytic residues [active] 568707007369 catalytic residues [active] 568707007370 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007371 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568707007372 EamA-like transporter family; Region: EamA; pfam00892 568707007373 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568707007374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707007375 NAD(P) binding site [chemical binding]; other site 568707007376 active site 568707007377 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 568707007378 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 568707007379 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 568707007380 DctM-like transporters; Region: DctM; pfam06808 568707007381 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568707007382 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707007383 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707007384 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707007385 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707007386 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707007387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707007388 DNA-binding site [nucleotide binding]; DNA binding site 568707007389 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 568707007390 FCD domain; Region: FCD; pfam07729 568707007391 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 568707007392 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 568707007393 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 568707007394 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 568707007395 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568707007396 homodimer interface [polypeptide binding]; other site 568707007397 substrate-cofactor binding pocket; other site 568707007398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707007399 catalytic residue [active] 568707007400 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 568707007401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007402 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707007403 dimerization interface [polypeptide binding]; other site 568707007404 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 568707007405 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 568707007406 active site 568707007407 iron coordination sites [ion binding]; other site 568707007408 substrate binding pocket [chemical binding]; other site 568707007410 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 568707007411 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 568707007412 putative ligand binding site [chemical binding]; other site 568707007413 putative NAD binding site [chemical binding]; other site 568707007414 catalytic site [active] 568707007415 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 568707007416 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 568707007417 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007418 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 568707007419 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 568707007420 tetramer interface [polypeptide binding]; other site 568707007421 active site 568707007422 Mg2+/Mn2+ binding site [ion binding]; other site 568707007423 aspartate aminotransferase; Provisional; Region: PRK05764 568707007424 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707007425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707007426 homodimer interface [polypeptide binding]; other site 568707007427 catalytic residue [active] 568707007428 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 568707007429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007430 dimer interface [polypeptide binding]; other site 568707007431 conserved gate region; other site 568707007432 putative PBP binding loops; other site 568707007433 ABC-ATPase subunit interface; other site 568707007434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007435 dimer interface [polypeptide binding]; other site 568707007436 conserved gate region; other site 568707007437 putative PBP binding loops; other site 568707007438 ABC-ATPase subunit interface; other site 568707007439 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568707007440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707007441 Walker A/P-loop; other site 568707007442 ATP binding site [chemical binding]; other site 568707007443 Q-loop/lid; other site 568707007444 ABC transporter signature motif; other site 568707007445 Walker B; other site 568707007446 D-loop; other site 568707007447 H-loop/switch region; other site 568707007448 TOBE domain; Region: TOBE_2; pfam08402 568707007449 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 568707007450 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568707007452 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707007453 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707007454 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007455 enoyl-CoA hydratase; Provisional; Region: PRK06688 568707007456 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707007457 substrate binding site [chemical binding]; other site 568707007458 oxyanion hole (OAH) forming residues; other site 568707007459 trimer interface [polypeptide binding]; other site 568707007460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707007461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007462 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 568707007463 putative dimerization interface [polypeptide binding]; other site 568707007464 putative substrate binding pocket [chemical binding]; other site 568707007465 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568707007466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007467 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 568707007468 putative dimerization interface [polypeptide binding]; other site 568707007469 putative substrate binding pocket [chemical binding]; other site 568707007470 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 568707007471 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 568707007472 dimer interface [polypeptide binding]; other site 568707007473 active site 568707007474 catalytic residue [active] 568707007475 metal binding site [ion binding]; metal-binding site 568707007476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 568707007477 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 568707007478 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568707007479 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568707007480 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007481 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707007482 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707007483 substrate binding site [chemical binding]; other site 568707007484 oxyanion hole (OAH) forming residues; other site 568707007485 trimer interface [polypeptide binding]; other site 568707007486 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707007488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007489 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 568707007490 putative dimerization interface [polypeptide binding]; other site 568707007491 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568707007492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568707007493 Uncharacterized conserved protein [Function unknown]; Region: COG3339 568707007494 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707007495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007496 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 568707007497 putative dimerization interface [polypeptide binding]; other site 568707007498 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707007499 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707007500 Walker A/P-loop; other site 568707007501 ATP binding site [chemical binding]; other site 568707007502 Q-loop/lid; other site 568707007503 ABC transporter signature motif; other site 568707007504 Walker B; other site 568707007505 D-loop; other site 568707007506 H-loop/switch region; other site 568707007507 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707007508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007509 dimer interface [polypeptide binding]; other site 568707007510 conserved gate region; other site 568707007511 putative PBP binding loops; other site 568707007512 ABC-ATPase subunit interface; other site 568707007513 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568707007514 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 568707007515 isopropylmalate isomerase large subunit; Provisional; Region: PRK12466 568707007516 substrate binding site [chemical binding]; other site 568707007517 ligand binding site [chemical binding]; other site 568707007518 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 568707007519 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 568707007520 substrate binding site [chemical binding]; other site 568707007521 tartrate dehydrogenase; Region: TTC; TIGR02089 568707007522 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 568707007523 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 568707007524 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 568707007525 active site 568707007526 Zn binding site [ion binding]; other site 568707007527 ornithine cyclodeaminase; Validated; Region: PRK06141 568707007528 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 568707007529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007530 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568707007531 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707007532 dimerization interface [polypeptide binding]; other site 568707007533 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 568707007534 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 568707007535 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 568707007536 Sulfatase; Region: Sulfatase; cl17466 568707007537 Sulfatase; Region: Sulfatase; cl17466 568707007538 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 568707007539 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 568707007540 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568707007541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007542 dimer interface [polypeptide binding]; other site 568707007543 conserved gate region; other site 568707007544 putative PBP binding loops; other site 568707007545 ABC-ATPase subunit interface; other site 568707007546 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707007547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007548 dimer interface [polypeptide binding]; other site 568707007549 conserved gate region; other site 568707007550 putative PBP binding loops; other site 568707007551 ABC-ATPase subunit interface; other site 568707007552 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 568707007553 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707007554 Walker A/P-loop; other site 568707007555 ATP binding site [chemical binding]; other site 568707007556 Q-loop/lid; other site 568707007557 ABC transporter signature motif; other site 568707007558 Walker B; other site 568707007559 D-loop; other site 568707007560 H-loop/switch region; other site 568707007561 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707007562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707007563 Walker A/P-loop; other site 568707007564 ATP binding site [chemical binding]; other site 568707007565 Q-loop/lid; other site 568707007566 ABC transporter signature motif; other site 568707007567 Walker B; other site 568707007568 D-loop; other site 568707007569 H-loop/switch region; other site 568707007570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707007571 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707007572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007573 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 568707007574 putative dimerization interface [polypeptide binding]; other site 568707007575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707007576 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 568707007577 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707007578 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707007579 acyl-activating enzyme (AAE) consensus motif; other site 568707007580 AMP binding site [chemical binding]; other site 568707007581 active site 568707007582 CoA binding site [chemical binding]; other site 568707007583 enoyl-CoA hydratase; Provisional; Region: PRK06494 568707007584 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707007585 substrate binding site [chemical binding]; other site 568707007586 oxyanion hole (OAH) forming residues; other site 568707007587 trimer interface [polypeptide binding]; other site 568707007588 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 568707007589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007590 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 568707007591 putative dimerization interface [polypeptide binding]; other site 568707007592 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568707007593 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 568707007594 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 568707007595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007596 dimer interface [polypeptide binding]; other site 568707007597 conserved gate region; other site 568707007598 putative PBP binding loops; other site 568707007599 ABC-ATPase subunit interface; other site 568707007600 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568707007601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007602 putative PBP binding loops; other site 568707007603 ABC-ATPase subunit interface; other site 568707007604 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568707007605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707007606 Walker A/P-loop; other site 568707007607 ATP binding site [chemical binding]; other site 568707007608 Q-loop/lid; other site 568707007609 ABC transporter signature motif; other site 568707007610 Walker B; other site 568707007611 D-loop; other site 568707007612 H-loop/switch region; other site 568707007613 TOBE domain; Region: TOBE_2; pfam08402 568707007614 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 568707007615 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 568707007616 active site 568707007617 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568707007618 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568707007619 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 568707007620 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 568707007621 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707007622 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707007623 metal binding site [ion binding]; metal-binding site 568707007624 active site 568707007625 I-site; other site 568707007626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707007627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007628 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707007629 dimerization interface [polypeptide binding]; other site 568707007630 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007631 Uncharacterized conserved protein [Function unknown]; Region: COG5476 568707007632 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 568707007633 MlrC C-terminus; Region: MlrC_C; pfam07171 568707007634 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568707007635 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007636 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 568707007637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007638 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 568707007639 putative dimerization interface [polypeptide binding]; other site 568707007640 putative substrate binding pocket [chemical binding]; other site 568707007641 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007642 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707007643 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707007644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707007645 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707007646 active site 568707007647 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568707007648 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568707007649 Ligand Binding Site [chemical binding]; other site 568707007650 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 568707007651 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 568707007652 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 568707007653 L-lactate permease; Region: Lactate_perm; cl00701 568707007654 L-lactate permease; Region: Lactate_perm; cl00701 568707007655 Isochorismatase family; Region: Isochorismatase; pfam00857 568707007656 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 568707007657 catalytic triad [active] 568707007658 dimer interface [polypeptide binding]; other site 568707007659 conserved cis-peptide bond; other site 568707007660 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568707007661 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568707007662 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 568707007663 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707007664 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 568707007665 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707007666 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007668 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707007669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007670 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707007671 dimerization interface [polypeptide binding]; other site 568707007672 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007673 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 568707007674 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 568707007675 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 568707007676 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 568707007677 oligomerisation interface [polypeptide binding]; other site 568707007678 mobile loop; other site 568707007679 roof hairpin; other site 568707007680 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 568707007681 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 568707007682 ring oligomerisation interface [polypeptide binding]; other site 568707007683 ATP/Mg binding site [chemical binding]; other site 568707007684 stacking interactions; other site 568707007685 hinge regions; other site 568707007686 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 568707007687 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568707007688 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707007689 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 568707007690 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 568707007691 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 568707007692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707007693 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 568707007694 active site 568707007695 dimer interface [polypeptide binding]; other site 568707007696 Competence-damaged protein; Region: CinA; pfam02464 568707007697 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 568707007698 tetramer interfaces [polypeptide binding]; other site 568707007699 binuclear metal-binding site [ion binding]; other site 568707007700 thiamine monophosphate kinase; Provisional; Region: PRK05731 568707007701 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 568707007702 ATP binding site [chemical binding]; other site 568707007703 dimerization interface [polypeptide binding]; other site 568707007704 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 568707007705 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 568707007706 homopentamer interface [polypeptide binding]; other site 568707007707 active site 568707007708 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 568707007709 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 568707007710 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 568707007711 dimerization interface [polypeptide binding]; other site 568707007712 active site 568707007713 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 568707007714 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568707007715 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707007716 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707007717 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707007718 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 568707007719 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707007720 substrate binding pocket [chemical binding]; other site 568707007721 membrane-bound complex binding site; other site 568707007722 hinge residues; other site 568707007723 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 568707007724 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 568707007725 Walker A/P-loop; other site 568707007726 ATP binding site [chemical binding]; other site 568707007727 Q-loop/lid; other site 568707007728 ABC transporter signature motif; other site 568707007729 Walker B; other site 568707007730 D-loop; other site 568707007731 H-loop/switch region; other site 568707007732 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 568707007733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007734 dimer interface [polypeptide binding]; other site 568707007735 conserved gate region; other site 568707007736 ABC-ATPase subunit interface; other site 568707007737 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 568707007738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007739 dimer interface [polypeptide binding]; other site 568707007740 conserved gate region; other site 568707007741 ABC-ATPase subunit interface; other site 568707007742 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 568707007743 putative active site [active] 568707007744 putative metal binding residues [ion binding]; other site 568707007745 signature motif; other site 568707007746 putative triphosphate binding site [ion binding]; other site 568707007747 CHAD domain; Region: CHAD; pfam05235 568707007748 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 568707007749 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 568707007750 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568707007751 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 568707007752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707007753 S-adenosylmethionine binding site [chemical binding]; other site 568707007754 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 568707007755 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 568707007756 active site 568707007757 (T/H)XGH motif; other site 568707007758 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 568707007759 Benzoate membrane transport protein; Region: BenE; pfam03594 568707007760 benzoate transporter; Region: benE; TIGR00843 568707007761 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 568707007762 AsmA family; Region: AsmA; pfam05170 568707007763 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 568707007764 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707007765 dimerization interface [polypeptide binding]; other site 568707007766 putative DNA binding site [nucleotide binding]; other site 568707007767 putative Zn2+ binding site [ion binding]; other site 568707007768 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 568707007769 putative hydrophobic ligand binding site [chemical binding]; other site 568707007770 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707007771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007772 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707007773 dimerization interface [polypeptide binding]; other site 568707007774 Uncharacterized conserved protein [Function unknown]; Region: COG5476 568707007775 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 568707007776 MlrC C-terminus; Region: MlrC_C; pfam07171 568707007777 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568707007778 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 568707007779 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 568707007780 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707007781 Walker A/P-loop; other site 568707007782 ATP binding site [chemical binding]; other site 568707007783 Q-loop/lid; other site 568707007784 ABC transporter signature motif; other site 568707007785 Walker B; other site 568707007786 D-loop; other site 568707007787 H-loop/switch region; other site 568707007788 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707007789 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707007790 Walker A/P-loop; other site 568707007791 ATP binding site [chemical binding]; other site 568707007792 Q-loop/lid; other site 568707007793 ABC transporter signature motif; other site 568707007794 Walker B; other site 568707007795 D-loop; other site 568707007796 H-loop/switch region; other site 568707007797 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568707007798 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568707007799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007800 dimer interface [polypeptide binding]; other site 568707007801 conserved gate region; other site 568707007802 putative PBP binding loops; other site 568707007803 ABC-ATPase subunit interface; other site 568707007804 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707007805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707007806 dimer interface [polypeptide binding]; other site 568707007807 conserved gate region; other site 568707007808 putative PBP binding loops; other site 568707007809 ABC-ATPase subunit interface; other site 568707007810 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 568707007811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007812 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707007813 dimerization interface [polypeptide binding]; other site 568707007814 malic enzyme; Reviewed; Region: PRK12861 568707007815 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568707007816 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 568707007817 putative NAD(P) binding site [chemical binding]; other site 568707007818 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 568707007819 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 568707007820 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 568707007821 active site 568707007822 iron coordination sites [ion binding]; other site 568707007823 substrate binding pocket [chemical binding]; other site 568707007824 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007825 thiamine pyrophosphate protein; Validated; Region: PRK08199 568707007826 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707007827 PYR/PP interface [polypeptide binding]; other site 568707007828 dimer interface [polypeptide binding]; other site 568707007829 TPP binding site [chemical binding]; other site 568707007830 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707007831 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 568707007832 TPP-binding site [chemical binding]; other site 568707007833 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707007834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707007835 DNA-binding site [nucleotide binding]; DNA binding site 568707007836 FCD domain; Region: FCD; pfam07729 568707007837 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707007838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707007839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707007840 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707007842 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 568707007843 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 568707007844 SIR2-like domain; Region: SIR2_2; pfam13289 568707007845 HerA helicase [Replication, recombination, and repair]; Region: COG0433 568707007846 Domain of unknown function DUF87; Region: DUF87; pfam01935 568707007847 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 568707007848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568707007849 ATP binding site [chemical binding]; other site 568707007850 putative Mg++ binding site [ion binding]; other site 568707007851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568707007852 nucleotide binding region [chemical binding]; other site 568707007853 ATP-binding site [chemical binding]; other site 568707007855 GTP-binding protein YchF; Reviewed; Region: PRK09601 568707007856 YchF GTPase; Region: YchF; cd01900 568707007857 G1 box; other site 568707007858 GTP/Mg2+ binding site [chemical binding]; other site 568707007859 Switch I region; other site 568707007860 G2 box; other site 568707007861 Switch II region; other site 568707007862 G3 box; other site 568707007863 G4 box; other site 568707007864 G5 box; other site 568707007865 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 568707007866 CAAX protease self-immunity; Region: Abi; cl00558 568707007867 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 568707007868 putative active site [active] 568707007869 catalytic residue [active] 568707007870 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 568707007871 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 568707007872 5S rRNA interface [nucleotide binding]; other site 568707007873 CTC domain interface [polypeptide binding]; other site 568707007874 L16 interface [polypeptide binding]; other site 568707007875 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 568707007876 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 568707007877 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568707007878 active site 568707007879 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 568707007880 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 568707007881 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 568707007882 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 568707007883 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 568707007884 TPR repeat; Region: TPR_11; pfam13414 568707007885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568707007886 binding surface 568707007887 TPR motif; other site 568707007888 TPR repeat; Region: TPR_11; pfam13414 568707007889 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 568707007890 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 568707007891 DNA binding site [nucleotide binding] 568707007892 putative catalytic residues [active] 568707007893 turnover-facilitating residue; other site 568707007894 intercalation triad [nucleotide binding]; other site 568707007895 8OG recognition residue [nucleotide binding]; other site 568707007896 putative reading head residues; other site 568707007897 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 568707007898 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568707007899 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568707007900 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 568707007901 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568707007902 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568707007903 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 568707007904 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 568707007905 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707007906 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 568707007907 substrate binding pocket [chemical binding]; other site 568707007908 dimerization interface [polypeptide binding]; other site 568707007909 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 568707007910 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 568707007911 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 568707007912 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568707007913 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 568707007914 Sulfatase; Region: Sulfatase; pfam00884 568707007915 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568707007916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707007917 dimer interface [polypeptide binding]; other site 568707007918 phosphorylation site [posttranslational modification] 568707007919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707007920 ATP binding site [chemical binding]; other site 568707007921 Mg2+ binding site [ion binding]; other site 568707007922 G-X-G motif; other site 568707007923 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568707007924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707007925 active site 568707007926 phosphorylation site [posttranslational modification] 568707007927 intermolecular recognition site; other site 568707007928 dimerization interface [polypeptide binding]; other site 568707007929 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707007930 DNA binding site [nucleotide binding] 568707007931 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 568707007932 FAD binding domain; Region: FAD_binding_4; pfam01565 568707007933 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568707007934 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 568707007935 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 568707007936 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 568707007937 active site 568707007938 substrate binding site [chemical binding]; other site 568707007939 metal binding site [ion binding]; metal-binding site 568707007940 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 568707007941 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 568707007942 active site 568707007943 dimer interface [polypeptide binding]; other site 568707007944 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 568707007945 dimer interface [polypeptide binding]; other site 568707007946 active site 568707007947 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 568707007948 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707007949 putative ADP-binding pocket [chemical binding]; other site 568707007950 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 568707007951 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 568707007952 putative ADP-binding pocket [chemical binding]; other site 568707007953 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 568707007954 putative ADP-binding pocket [chemical binding]; other site 568707007955 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707007956 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 568707007957 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 568707007958 active site 568707007959 dimer interface [polypeptide binding]; other site 568707007960 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 568707007961 Ligand Binding Site [chemical binding]; other site 568707007962 Molecular Tunnel; other site 568707007963 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707007964 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 568707007965 putative ADP-binding pocket [chemical binding]; other site 568707007966 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 568707007967 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 568707007968 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 568707007969 NAD binding site [chemical binding]; other site 568707007970 substrate binding site [chemical binding]; other site 568707007971 homodimer interface [polypeptide binding]; other site 568707007972 active site 568707007974 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 568707007975 Mg++ binding site [ion binding]; other site 568707007976 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 568707007977 putative catalytic motif [active] 568707007978 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 568707007979 diiron binding motif [ion binding]; other site 568707007980 OsmC-like protein; Region: OsmC; cl00767 568707007981 thymidylate synthase; Provisional; Region: thyA; PRK13821 568707007982 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 568707007983 dimerization interface [polypeptide binding]; other site 568707007984 active site 568707007985 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 568707007986 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 568707007987 folate binding site [chemical binding]; other site 568707007988 NADP+ binding site [chemical binding]; other site 568707007989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707007990 DNA-binding site [nucleotide binding]; DNA binding site 568707007991 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 568707007992 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707007993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707007994 homodimer interface [polypeptide binding]; other site 568707007995 catalytic residue [active] 568707007996 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 568707007997 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568707007998 inhibitor-cofactor binding pocket; inhibition site 568707007999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707008000 catalytic residue [active] 568707008001 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 568707008002 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 568707008003 tetrameric interface [polypeptide binding]; other site 568707008004 NAD binding site [chemical binding]; other site 568707008005 catalytic residues [active] 568707008006 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 568707008007 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 568707008008 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707008009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707008010 dimer interface [polypeptide binding]; other site 568707008011 conserved gate region; other site 568707008012 putative PBP binding loops; other site 568707008013 ABC-ATPase subunit interface; other site 568707008014 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568707008015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707008016 dimer interface [polypeptide binding]; other site 568707008017 conserved gate region; other site 568707008018 putative PBP binding loops; other site 568707008019 ABC-ATPase subunit interface; other site 568707008020 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 568707008021 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707008022 Walker A/P-loop; other site 568707008023 ATP binding site [chemical binding]; other site 568707008024 Q-loop/lid; other site 568707008025 ABC transporter signature motif; other site 568707008026 Walker B; other site 568707008027 D-loop; other site 568707008028 H-loop/switch region; other site 568707008029 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707008030 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707008031 Walker A/P-loop; other site 568707008032 ATP binding site [chemical binding]; other site 568707008033 Q-loop/lid; other site 568707008034 ABC transporter signature motif; other site 568707008035 Walker B; other site 568707008036 D-loop; other site 568707008037 H-loop/switch region; other site 568707008038 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707008039 Uncharacterized conserved protein [Function unknown]; Region: COG5476 568707008040 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 568707008041 MlrC C-terminus; Region: MlrC_C; pfam07171 568707008042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 568707008043 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 568707008044 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 568707008045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 568707008046 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 568707008047 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707008048 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707008049 substrate binding site [chemical binding]; other site 568707008050 oxyanion hole (OAH) forming residues; other site 568707008051 trimer interface [polypeptide binding]; other site 568707008052 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 568707008053 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008054 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707008055 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707008056 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568707008057 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707008058 DNA-binding site [nucleotide binding]; DNA binding site 568707008059 FCD domain; Region: FCD; pfam07729 568707008060 glycine dehydrogenase; Provisional; Region: PRK05367 568707008061 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 568707008062 tetramer interface [polypeptide binding]; other site 568707008063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707008064 catalytic residue [active] 568707008065 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 568707008066 tetramer interface [polypeptide binding]; other site 568707008067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707008068 catalytic residue [active] 568707008069 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 568707008070 lipoyl attachment site [posttranslational modification]; other site 568707008071 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 568707008072 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 568707008073 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 568707008074 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 568707008075 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 568707008076 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 568707008077 HI0933-like protein; Region: HI0933_like; pfam03486 568707008078 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 568707008079 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 568707008080 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568707008081 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568707008082 catalytic residue [active] 568707008083 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 568707008084 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 568707008085 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568707008086 Coenzyme A binding pocket [chemical binding]; other site 568707008087 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 568707008088 active site 568707008089 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 568707008090 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568707008091 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 568707008092 trimer interface [polypeptide binding]; other site 568707008093 active site 568707008094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 568707008095 Family of unknown function (DUF490); Region: DUF490; pfam04357 568707008096 Surface antigen; Region: Bac_surface_Ag; pfam01103 568707008097 Domain of unknown function DUF59; Region: DUF59; cl00941 568707008098 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 568707008099 Walker A motif; other site 568707008100 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 568707008101 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 568707008102 active site 568707008103 HIGH motif; other site 568707008104 KMSKS motif; other site 568707008105 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 568707008106 tRNA binding surface [nucleotide binding]; other site 568707008107 anticodon binding site; other site 568707008108 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 568707008109 dimer interface [polypeptide binding]; other site 568707008110 putative tRNA-binding site [nucleotide binding]; other site 568707008111 rhodanese superfamily protein; Provisional; Region: PRK05320 568707008112 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 568707008113 active site residue [active] 568707008114 META domain; Region: META; pfam03724 568707008115 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 568707008116 META domain; Region: META; pfam03724 568707008117 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568707008118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 568707008119 active site 568707008120 intermolecular recognition site; other site 568707008121 dimerization interface [polypeptide binding]; other site 568707008122 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 568707008123 DNA binding site [nucleotide binding] 568707008124 Arginase family; Region: Arginase; cd09989 568707008125 active site 568707008126 Mn binding site [ion binding]; other site 568707008127 oligomer interface [polypeptide binding]; other site 568707008128 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 568707008129 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568707008130 inhibitor-cofactor binding pocket; inhibition site 568707008131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707008132 catalytic residue [active] 568707008133 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568707008134 AsnC family; Region: AsnC_trans_reg; pfam01037 568707008135 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 568707008136 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707008137 N-terminal plug; other site 568707008138 ligand-binding site [chemical binding]; other site 568707008140 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 568707008141 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568707008142 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568707008143 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568707008144 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 568707008145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707008146 dimer interface [polypeptide binding]; other site 568707008147 conserved gate region; other site 568707008148 putative PBP binding loops; other site 568707008149 ABC-ATPase subunit interface; other site 568707008150 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 568707008151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707008152 Walker A/P-loop; other site 568707008153 ATP binding site [chemical binding]; other site 568707008154 Q-loop/lid; other site 568707008155 ABC transporter signature motif; other site 568707008156 Walker B; other site 568707008157 D-loop; other site 568707008158 H-loop/switch region; other site 568707008159 TOBE domain; Region: TOBE; pfam03459 568707008160 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 568707008161 putative active site [active] 568707008162 catalytic site [active] 568707008163 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 568707008164 PLD-like domain; Region: PLDc_2; pfam13091 568707008165 putative active site [active] 568707008166 catalytic site [active] 568707008167 Uncharacterized conserved protein [Function unknown]; Region: COG5361 568707008168 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 568707008169 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 568707008170 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 568707008171 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 568707008172 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 568707008173 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 568707008174 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 568707008175 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 568707008176 hypothetical protein; Provisional; Region: PRK07033 568707008177 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 568707008178 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568707008179 ligand binding site [chemical binding]; other site 568707008180 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 568707008181 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 568707008182 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 568707008183 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 568707008184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707008185 Walker A motif; other site 568707008186 ATP binding site [chemical binding]; other site 568707008187 Walker B motif; other site 568707008188 arginine finger; other site 568707008189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707008190 Walker A motif; other site 568707008191 ATP binding site [chemical binding]; other site 568707008192 Walker B motif; other site 568707008193 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 568707008194 Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; pfam09961 568707008195 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 568707008196 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 568707008197 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 568707008198 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 568707008199 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 568707008200 ImpE protein; Region: ImpE; pfam07024 568707008201 Protein of unknown function (DUF796); Region: DUF796; pfam05638 568707008202 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 568707008203 Protein of unknown function (DUF877); Region: DUF877; pfam05943 568707008204 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 568707008205 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 568707008206 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 568707008207 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 568707008208 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 568707008209 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 568707008210 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 568707008211 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 568707008212 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 568707008213 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 568707008214 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 568707008215 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 568707008216 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 568707008217 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 568707008218 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 568707008219 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 568707008220 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 568707008221 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 568707008222 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 568707008223 Walker A motif; other site 568707008224 ATP binding site [chemical binding]; other site 568707008225 Walker B motif; other site 568707008226 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 568707008227 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 568707008228 AAA domain; Region: AAA_22; pfam13401 568707008229 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568707008230 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 568707008231 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 568707008232 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 568707008233 Walker A motif; other site 568707008234 ATP binding site [chemical binding]; other site 568707008235 Walker B motif; other site 568707008236 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 568707008237 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 568707008238 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 568707008239 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 568707008240 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 568707008241 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 568707008242 Bacterial transcriptional activator domain; Region: BTAD; smart01043 568707008243 Predicted ATPase [General function prediction only]; Region: COG3899 568707008244 AAA ATPase domain; Region: AAA_16; pfam13191 568707008245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 568707008246 TPR motif; other site 568707008247 Tetratricopeptide repeat; Region: TPR_12; pfam13424 568707008248 binding surface 568707008249 Putative cyclase; Region: Cyclase; pfam04199 568707008250 Putative cyclase; Region: Cyclase; cl00814 568707008251 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707008253 NAD(P) binding site [chemical binding]; other site 568707008254 active site 568707008255 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707008256 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 568707008257 dimer interaction site [polypeptide binding]; other site 568707008258 substrate-binding tunnel; other site 568707008259 active site 568707008260 catalytic site [active] 568707008261 substrate binding site [chemical binding]; other site 568707008262 thiolase; Provisional; Region: PRK06158 568707008263 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 568707008264 active site 568707008265 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 568707008266 DUF35 OB-fold domain; Region: DUF35; pfam01796 568707008267 enoyl-CoA hydratase; Provisional; Region: PRK08252 568707008268 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707008269 substrate binding site [chemical binding]; other site 568707008270 oxyanion hole (OAH) forming residues; other site 568707008271 trimer interface [polypeptide binding]; other site 568707008272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707008273 NAD(P) binding site [chemical binding]; other site 568707008274 active site 568707008275 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707008276 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 568707008277 ligand binding site [chemical binding]; other site 568707008278 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707008279 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707008280 Walker A/P-loop; other site 568707008281 ATP binding site [chemical binding]; other site 568707008282 Q-loop/lid; other site 568707008283 ABC transporter signature motif; other site 568707008284 Walker B; other site 568707008285 D-loop; other site 568707008286 H-loop/switch region; other site 568707008287 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707008288 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707008289 Walker A/P-loop; other site 568707008290 ATP binding site [chemical binding]; other site 568707008291 Q-loop/lid; other site 568707008292 ABC transporter signature motif; other site 568707008293 Walker B; other site 568707008294 D-loop; other site 568707008295 H-loop/switch region; other site 568707008296 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707008297 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707008298 TM-ABC transporter signature motif; other site 568707008299 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707008300 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707008301 TM-ABC transporter signature motif; other site 568707008302 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707008303 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707008304 active site 568707008305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707008306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707008307 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 568707008308 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707008309 acyl-activating enzyme (AAE) consensus motif; other site 568707008310 AMP binding site [chemical binding]; other site 568707008311 active site 568707008312 CoA binding site [chemical binding]; other site 568707008313 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707008314 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707008315 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 568707008316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707008317 NAD(P) binding site [chemical binding]; other site 568707008318 active site 568707008319 enoyl-CoA hydratase; Provisional; Region: PRK09245 568707008320 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707008321 substrate binding site [chemical binding]; other site 568707008322 oxyanion hole (OAH) forming residues; other site 568707008323 trimer interface [polypeptide binding]; other site 568707008324 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008325 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 568707008326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707008327 non-specific DNA binding site [nucleotide binding]; other site 568707008328 salt bridge; other site 568707008329 sequence-specific DNA binding site [nucleotide binding]; other site 568707008330 Cupin domain; Region: Cupin_2; pfam07883 568707008331 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 568707008332 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 568707008333 substrate binding pocket [chemical binding]; other site 568707008334 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568707008335 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 568707008336 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707008337 NAD(P) binding site [chemical binding]; other site 568707008338 catalytic residues [active] 568707008339 hypothetical protein; Provisional; Region: PRK08266 568707008340 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707008341 PYR/PP interface [polypeptide binding]; other site 568707008342 dimer interface [polypeptide binding]; other site 568707008343 TPP binding site [chemical binding]; other site 568707008344 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707008345 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 568707008346 TPP-binding site [chemical binding]; other site 568707008347 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008348 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 568707008349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707008350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707008351 dimerization interface [polypeptide binding]; other site 568707008352 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 568707008353 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 568707008354 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 568707008355 putative substrate binding pocket [chemical binding]; other site 568707008356 trimer interface [polypeptide binding]; other site 568707008357 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 568707008358 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 568707008359 putative active site [active] 568707008360 putative metal binding site [ion binding]; other site 568707008361 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 568707008362 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 568707008363 NAD binding site [chemical binding]; other site 568707008364 catalytic residues [active] 568707008365 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 568707008366 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568707008367 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 568707008368 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008369 hypothetical protein; Provisional; Region: PRK06126 568707008370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568707008371 hypothetical protein; Provisional; Region: PRK07236 568707008372 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 568707008373 inter-subunit interface; other site 568707008374 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 568707008375 classical (c) SDRs; Region: SDR_c; cd05233 568707008376 NAD(P) binding site [chemical binding]; other site 568707008377 active site 568707008378 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 568707008379 iron-sulfur cluster [ion binding]; other site 568707008380 [2Fe-2S] cluster binding site [ion binding]; other site 568707008381 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 568707008382 beta subunit interface [polypeptide binding]; other site 568707008383 alpha subunit interface [polypeptide binding]; other site 568707008384 active site 568707008385 substrate binding site [chemical binding]; other site 568707008386 Fe binding site [ion binding]; other site 568707008387 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568707008388 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707008389 catalytic loop [active] 568707008390 iron binding site [ion binding]; other site 568707008391 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 568707008392 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 568707008393 FAD binding pocket [chemical binding]; other site 568707008394 conserved FAD binding motif [chemical binding]; other site 568707008395 phosphate binding motif [ion binding]; other site 568707008396 beta-alpha-beta structure motif; other site 568707008397 NAD binding pocket [chemical binding]; other site 568707008398 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008399 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707008400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707008401 putative DNA binding site [nucleotide binding]; other site 568707008402 putative Zn2+ binding site [ion binding]; other site 568707008403 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707008404 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 568707008405 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 568707008406 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 568707008407 Strictosidine synthase; Region: Str_synth; pfam03088 568707008408 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568707008409 DctM-like transporters; Region: DctM; pfam06808 568707008410 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707008411 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707008412 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 568707008413 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 568707008414 tetramer interface [polypeptide binding]; other site 568707008415 active site 568707008416 Mg2+/Mn2+ binding site [ion binding]; other site 568707008417 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008418 Isochorismatase family; Region: Isochorismatase; pfam00857 568707008419 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 568707008420 catalytic triad [active] 568707008421 conserved cis-peptide bond; other site 568707008422 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707008423 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707008424 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 568707008425 active site 568707008426 catalytic residues [active] 568707008427 metal binding site [ion binding]; metal-binding site 568707008428 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707008429 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707008430 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707008431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707008432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707008433 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 568707008434 putative dimerization interface [polypeptide binding]; other site 568707008435 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 568707008436 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 568707008437 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 568707008438 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 568707008439 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 568707008440 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 568707008441 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 568707008442 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 568707008443 Benzoate membrane transport protein; Region: BenE; pfam03594 568707008444 benzoate transporter; Region: benE; TIGR00843 568707008445 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 568707008446 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 568707008447 dimer interface [polypeptide binding]; other site 568707008448 active site 568707008449 glycine-pyridoxal phosphate binding site [chemical binding]; other site 568707008450 folate binding site [chemical binding]; other site 568707008451 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 568707008452 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707008453 DNA-binding site [nucleotide binding]; DNA binding site 568707008454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707008455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707008456 homodimer interface [polypeptide binding]; other site 568707008457 catalytic residue [active] 568707008458 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707008459 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 568707008460 DctM-like transporters; Region: DctM; pfam06808 568707008461 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 568707008462 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 568707008463 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707008464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707008465 FCD domain; Region: FCD; pfam07729 568707008466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707008467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707008468 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 568707008469 putative dimerization interface [polypeptide binding]; other site 568707008470 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707008471 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707008472 DctM-like transporters; Region: DctM; pfam06808 568707008473 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 568707008474 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 568707008475 ureidoglycolate hydrolase; Provisional; Region: PRK03606 568707008476 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 568707008477 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 568707008478 active site 568707008479 catalytic site [active] 568707008480 tetramer interface [polypeptide binding]; other site 568707008481 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568707008482 Amidase; Region: Amidase; cl11426 568707008483 allantoate amidohydrolase; Reviewed; Region: PRK12892 568707008484 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 568707008485 active site 568707008486 metal binding site [ion binding]; metal-binding site 568707008487 dimer interface [polypeptide binding]; other site 568707008488 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 568707008489 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707008490 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707008491 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 568707008492 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 568707008493 metal binding site [ion binding]; metal-binding site 568707008494 putative dimer interface [polypeptide binding]; other site 568707008495 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568707008496 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568707008497 Walker A/P-loop; other site 568707008498 ATP binding site [chemical binding]; other site 568707008499 Q-loop/lid; other site 568707008500 ABC transporter signature motif; other site 568707008501 Walker B; other site 568707008502 D-loop; other site 568707008503 H-loop/switch region; other site 568707008504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707008505 dimer interface [polypeptide binding]; other site 568707008506 conserved gate region; other site 568707008507 putative PBP binding loops; other site 568707008508 ABC-ATPase subunit interface; other site 568707008509 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707008510 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568707008511 substrate binding pocket [chemical binding]; other site 568707008512 membrane-bound complex binding site; other site 568707008513 hinge residues; other site 568707008514 aspartate aminotransferase; Provisional; Region: PRK05764 568707008515 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707008516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707008517 homodimer interface [polypeptide binding]; other site 568707008518 catalytic residue [active] 568707008519 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 568707008520 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 568707008521 inhibitor site; inhibition site 568707008522 active site 568707008523 dimer interface [polypeptide binding]; other site 568707008524 catalytic residue [active] 568707008525 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707008526 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707008527 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707008528 FOG: WD40 repeat [General function prediction only]; Region: COG2319 568707008529 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 568707008530 structural tetrad; other site 568707008531 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 568707008532 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 568707008533 P-loop, Walker A motif; other site 568707008534 Base recognition motif; other site 568707008535 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 568707008536 Uncharacterized conserved protein [Function unknown]; Region: COG5276 568707008537 LVIVD repeat; Region: LVIVD; pfam08309 568707008538 LVIVD repeat; Region: LVIVD; pfam08309 568707008539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707008540 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 568707008541 homotrimer interaction site [polypeptide binding]; other site 568707008542 putative active site [active] 568707008543 cystathionine beta-lyase; Provisional; Region: PRK09028 568707008544 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568707008545 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568707008546 catalytic residue [active] 568707008547 aldehyde dehydrogenase family 7 member; Region: PLN02315 568707008548 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 568707008549 tetrameric interface [polypeptide binding]; other site 568707008550 NAD binding site [chemical binding]; other site 568707008551 catalytic residues [active] 568707008552 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707008553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707008554 DNA-binding site [nucleotide binding]; DNA binding site 568707008555 FCD domain; Region: FCD; pfam07729 568707008556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707008557 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008558 glutathionine S-transferase; Provisional; Region: PRK10542 568707008559 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 568707008560 C-terminal domain interface [polypeptide binding]; other site 568707008561 GSH binding site (G-site) [chemical binding]; other site 568707008562 dimer interface [polypeptide binding]; other site 568707008563 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 568707008564 dimer interface [polypeptide binding]; other site 568707008565 N-terminal domain interface [polypeptide binding]; other site 568707008566 substrate binding pocket (H-site) [chemical binding]; other site 568707008567 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 568707008568 Amino acid synthesis; Region: AA_synth; pfam06684 568707008569 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568707008570 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 568707008571 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568707008572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707008573 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707008574 dimerization interface [polypeptide binding]; other site 568707008575 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 568707008576 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 568707008577 CoA binding domain; Region: CoA_binding_2; pfam13380 568707008578 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 568707008579 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008580 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 568707008581 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568707008582 dimer interface [polypeptide binding]; other site 568707008583 active site 568707008584 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707008585 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707008586 substrate binding site [chemical binding]; other site 568707008587 oxyanion hole (OAH) forming residues; other site 568707008588 trimer interface [polypeptide binding]; other site 568707008589 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 568707008590 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707008591 FAD binding site [chemical binding]; other site 568707008592 substrate binding pocket [chemical binding]; other site 568707008593 catalytic base [active] 568707008594 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 568707008595 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707008596 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707008597 substrate binding site [chemical binding]; other site 568707008598 oxyanion hole (OAH) forming residues; other site 568707008599 trimer interface [polypeptide binding]; other site 568707008600 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008601 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707008602 active site 2 [active] 568707008603 active site 1 [active] 568707008604 Putative cyclase; Region: Cyclase; cl00814 568707008605 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 568707008606 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 568707008607 acyl-activating enzyme (AAE) consensus motif; other site 568707008608 putative AMP binding site [chemical binding]; other site 568707008609 putative active site [active] 568707008610 putative CoA binding site [chemical binding]; other site 568707008611 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707008612 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707008613 active site 568707008614 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707008615 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707008616 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707008617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707008618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707008619 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 568707008620 putative dimerization interface [polypeptide binding]; other site 568707008621 pyridoxal phosphate enzyme, MJ0158 family; Region: pyridox_MJ0158; TIGR03576 568707008622 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 568707008623 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707008625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707008626 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707008627 dimerization interface [polypeptide binding]; other site 568707008628 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 568707008629 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568707008630 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568707008631 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008632 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707008633 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 568707008634 NAD(P) binding site [chemical binding]; other site 568707008635 catalytic residues [active] 568707008636 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008637 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568707008638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707008639 NAD(P) binding site [chemical binding]; other site 568707008640 active site 568707008641 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568707008642 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568707008643 ligand binding site [chemical binding]; other site 568707008644 flexible hinge region; other site 568707008645 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 568707008646 putative switch regulator; other site 568707008647 non-specific DNA interactions [nucleotide binding]; other site 568707008648 DNA binding site [nucleotide binding] 568707008649 sequence specific DNA binding site [nucleotide binding]; other site 568707008650 putative cAMP binding site [chemical binding]; other site 568707008651 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707008652 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707008653 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707008654 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 568707008655 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 568707008656 NMT1/THI5 like; Region: NMT1; pfam09084 568707008657 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 568707008658 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707008659 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707008660 Walker A/P-loop; other site 568707008661 ATP binding site [chemical binding]; other site 568707008662 Q-loop/lid; other site 568707008663 ABC transporter signature motif; other site 568707008664 Walker B; other site 568707008665 D-loop; other site 568707008666 H-loop/switch region; other site 568707008667 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707008668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707008669 dimer interface [polypeptide binding]; other site 568707008670 conserved gate region; other site 568707008671 putative PBP binding loops; other site 568707008672 ABC-ATPase subunit interface; other site 568707008673 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 568707008674 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568707008675 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 568707008676 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707008677 NAD(P) binding site [chemical binding]; other site 568707008678 catalytic residues [active] 568707008679 N-formylglutamate amidohydrolase; Region: FGase; cl01522 568707008680 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568707008681 Amidase; Region: Amidase; cl11426 568707008682 enoyl-CoA hydratase; Provisional; Region: PRK06688 568707008683 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707008684 substrate binding site [chemical binding]; other site 568707008685 oxyanion hole (OAH) forming residues; other site 568707008686 trimer interface [polypeptide binding]; other site 568707008687 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 568707008688 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 568707008689 active site 568707008690 NAD binding site [chemical binding]; other site 568707008691 metal binding site [ion binding]; metal-binding site 568707008692 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008693 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707008694 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707008695 enoyl-CoA hydratase; Provisional; Region: PRK08252 568707008696 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707008697 substrate binding site [chemical binding]; other site 568707008698 oxyanion hole (OAH) forming residues; other site 568707008699 trimer interface [polypeptide binding]; other site 568707008700 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 568707008701 active site 568707008702 metal binding site [ion binding]; metal-binding site 568707008703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707008704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707008705 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 568707008706 putative FMN binding site [chemical binding]; other site 568707008707 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707008708 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707008709 substrate binding site [chemical binding]; other site 568707008710 oxyanion hole (OAH) forming residues; other site 568707008711 trimer interface [polypeptide binding]; other site 568707008712 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 568707008713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707008714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707008715 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008716 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008717 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 568707008718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707008719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707008720 The C-terminal substrate binding of LysR-type symbiotic regulator SyrM, which activates expression of nodulation gene NodD3, contains the type 2 periplasmic binding fold; Region: PBP2_SyrM; cd08467 568707008721 putative substrate binding pocket [chemical binding]; other site 568707008722 putative dimerization interface [polypeptide binding]; other site 568707008723 Uncharacterized conserved protein [Function unknown]; Region: COG3777 568707008724 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707008725 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707008726 active site 2 [active] 568707008727 active site 1 [active] 568707008728 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 568707008729 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 568707008730 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 568707008731 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 568707008732 Ligand binding site [chemical binding]; other site 568707008733 Electron transfer flavoprotein domain; Region: ETF; pfam01012 568707008734 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707008735 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 568707008736 active site 568707008737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707008738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707008739 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 568707008740 putative dimerization interface [polypeptide binding]; other site 568707008741 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707008742 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707008743 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707008744 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707008745 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707008746 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 568707008747 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 568707008748 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 568707008749 acyl-activating enzyme (AAE) consensus motif; other site 568707008750 putative AMP binding site [chemical binding]; other site 568707008751 putative active site [active] 568707008752 putative CoA binding site [chemical binding]; other site 568707008753 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 568707008754 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568707008755 dimer interface [polypeptide binding]; other site 568707008756 active site 568707008757 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 568707008758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707008759 NAD(P) binding site [chemical binding]; other site 568707008760 active site 568707008761 enoyl-CoA hydratase; Region: PLN02864 568707008762 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707008763 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 568707008764 dimer interaction site [polypeptide binding]; other site 568707008765 substrate-binding tunnel; other site 568707008766 active site 568707008767 catalytic site [active] 568707008768 substrate binding site [chemical binding]; other site 568707008769 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707008770 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707008771 active site 568707008772 pyruvate carboxylase; Reviewed; Region: PRK12999 568707008773 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568707008774 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568707008775 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568707008776 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 568707008777 active site 568707008778 catalytic residues [active] 568707008779 metal binding site [ion binding]; metal-binding site 568707008780 homodimer binding site [polypeptide binding]; other site 568707008781 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568707008782 carboxyltransferase (CT) interaction site; other site 568707008783 biotinylation site [posttranslational modification]; other site 568707008784 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707008785 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 568707008786 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707008787 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707008788 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 568707008789 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707008790 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 568707008791 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707008792 acyl-activating enzyme (AAE) consensus motif; other site 568707008793 AMP binding site [chemical binding]; other site 568707008794 active site 568707008795 CoA binding site [chemical binding]; other site 568707008796 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 568707008797 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 568707008798 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 568707008799 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008800 short chain dehydrogenase; Provisional; Region: PRK06125 568707008801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707008802 NAD(P) binding site [chemical binding]; other site 568707008803 active site 568707008804 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 568707008805 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 568707008806 putative active site [active] 568707008807 putative FMN binding site [chemical binding]; other site 568707008808 putative substrate binding site [chemical binding]; other site 568707008809 putative catalytic residue [active] 568707008810 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707008811 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707008812 Walker A/P-loop; other site 568707008813 ATP binding site [chemical binding]; other site 568707008814 Q-loop/lid; other site 568707008815 ABC transporter signature motif; other site 568707008816 Walker B; other site 568707008817 D-loop; other site 568707008818 H-loop/switch region; other site 568707008819 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707008820 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707008821 Walker A/P-loop; other site 568707008822 ATP binding site [chemical binding]; other site 568707008823 Q-loop/lid; other site 568707008824 ABC transporter signature motif; other site 568707008825 Walker B; other site 568707008826 D-loop; other site 568707008827 H-loop/switch region; other site 568707008828 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707008829 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707008830 TM-ABC transporter signature motif; other site 568707008831 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707008832 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707008833 TM-ABC transporter signature motif; other site 568707008834 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707008835 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 568707008836 putative ligand binding site [chemical binding]; other site 568707008837 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707008838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707008839 substrate binding site [chemical binding]; other site 568707008840 oxyanion hole (OAH) forming residues; other site 568707008841 trimer interface [polypeptide binding]; other site 568707008842 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 568707008843 putative FMN binding site [chemical binding]; other site 568707008844 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 568707008845 SnoaL-like domain; Region: SnoaL_3; pfam13474 568707008846 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008847 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707008848 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707008849 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707008850 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707008851 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707008852 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707008853 active site 568707008854 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 568707008855 putative active site [active] 568707008856 putative catalytic site [active] 568707008857 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 568707008858 putative succinate dehydrogenase; Reviewed; Region: PRK12842 568707008859 Predicted oxidoreductase [General function prediction only]; Region: COG3573 568707008860 SnoaL-like domain; Region: SnoaL_4; pfam13577 568707008861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707008862 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707008863 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707008864 substrate binding site [chemical binding]; other site 568707008865 oxyanion hole (OAH) forming residues; other site 568707008866 trimer interface [polypeptide binding]; other site 568707008867 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 568707008868 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707008869 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 568707008870 acyl-activating enzyme (AAE) consensus motif; other site 568707008871 putative AMP binding site [chemical binding]; other site 568707008872 putative active site [active] 568707008873 putative CoA binding site [chemical binding]; other site 568707008874 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568707008875 classical (c) SDRs; Region: SDR_c; cd05233 568707008876 NAD(P) binding site [chemical binding]; other site 568707008877 active site 568707008878 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707008879 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707008880 active site 568707008881 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 568707008882 classical (c) SDRs; Region: SDR_c; cd05233 568707008883 NAD(P) binding site [chemical binding]; other site 568707008884 active site 568707008885 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 568707008886 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 568707008887 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 568707008888 active site 568707008889 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 568707008890 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 568707008891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707008892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707008893 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707008894 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568707008895 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707008896 TM-ABC transporter signature motif; other site 568707008897 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707008898 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707008899 TM-ABC transporter signature motif; other site 568707008900 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707008901 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707008902 Walker A/P-loop; other site 568707008903 ATP binding site [chemical binding]; other site 568707008904 Q-loop/lid; other site 568707008905 ABC transporter signature motif; other site 568707008906 Walker B; other site 568707008907 D-loop; other site 568707008908 H-loop/switch region; other site 568707008909 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707008910 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707008911 Walker A/P-loop; other site 568707008912 ATP binding site [chemical binding]; other site 568707008913 Q-loop/lid; other site 568707008914 ABC transporter signature motif; other site 568707008915 Walker B; other site 568707008916 D-loop; other site 568707008917 H-loop/switch region; other site 568707008918 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 568707008919 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568707008920 tricarballylate dehydrogenase; Validated; Region: PRK08274 568707008921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568707008922 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 568707008923 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568707008924 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568707008925 DNA binding site [nucleotide binding] 568707008926 domain linker motif; other site 568707008927 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281 568707008928 putative dimerization interface [polypeptide binding]; other site 568707008929 putative ligand binding site [chemical binding]; other site 568707008930 acyl-CoA synthetase; Validated; Region: PRK06188 568707008931 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707008932 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 568707008933 acyl-activating enzyme (AAE) consensus motif; other site 568707008934 acyl-activating enzyme (AAE) consensus motif; other site 568707008935 putative AMP binding site [chemical binding]; other site 568707008936 putative active site [active] 568707008937 putative CoA binding site [chemical binding]; other site 568707008938 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 568707008939 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 568707008940 active site 568707008941 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 568707008942 DUF35 OB-fold domain; Region: DUF35; pfam01796 568707008943 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008944 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707008945 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707008946 putative DNA binding site [nucleotide binding]; other site 568707008947 putative Zn2+ binding site [ion binding]; other site 568707008948 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008949 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707008950 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707008951 substrate binding site [chemical binding]; other site 568707008952 oxyanion hole (OAH) forming residues; other site 568707008953 trimer interface [polypeptide binding]; other site 568707008954 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707008955 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707008956 hypothetical protein; Provisional; Region: PRK06154 568707008957 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707008958 PYR/PP interface [polypeptide binding]; other site 568707008959 dimer interface [polypeptide binding]; other site 568707008960 TPP binding site [chemical binding]; other site 568707008961 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707008962 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 568707008963 TPP-binding site; other site 568707008964 dimer interface [polypeptide binding]; other site 568707008965 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 568707008966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707008967 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 568707008968 putative dimerization interface [polypeptide binding]; other site 568707008969 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 568707008970 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 568707008971 active site residue [active] 568707008972 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 568707008973 active site residue [active] 568707008974 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 568707008975 active site residue [active] 568707008976 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008977 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 568707008978 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008979 enoyl-CoA hydratase; Provisional; Region: PRK08252 568707008980 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707008981 substrate binding site [chemical binding]; other site 568707008982 oxyanion hole (OAH) forming residues; other site 568707008983 trimer interface [polypeptide binding]; other site 568707008984 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 568707008985 CoA binding domain; Region: CoA_binding_2; pfam13380 568707008986 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 568707008987 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 568707008988 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707008989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707008990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707008991 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707008992 dimerization interface [polypeptide binding]; other site 568707008993 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568707008994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707008995 non-specific DNA binding site [nucleotide binding]; other site 568707008996 salt bridge; other site 568707008997 sequence-specific DNA binding site [nucleotide binding]; other site 568707008998 HipA N-terminal domain; Region: Couple_hipA; cl11853 568707008999 HipA-like N-terminal domain; Region: HipA_N; pfam07805 568707009000 HipA-like C-terminal domain; Region: HipA_C; pfam07804 568707009002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707009003 intracellular protease, PfpI family; Region: PfpI; TIGR01382 568707009004 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 568707009005 conserved cys residue [active] 568707009006 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 568707009007 iron-sulfur cluster [ion binding]; other site 568707009008 [2Fe-2S] cluster binding site [ion binding]; other site 568707009009 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707009010 catalytic loop [active] 568707009011 iron binding site [ion binding]; other site 568707009012 Toluene-4-monoxygenase electron transfer component of Pseudomonas mendocina hydroxylates toluene and forms p-cresol as part of a three component toluene-4-monoxygenase system. Electron transfer is from NADH to an NADH:ferredoxin oxidoreductase (TmoF in P; Region: T4MO_e_transfer_like; cd06190 568707009013 FAD binding pocket [chemical binding]; other site 568707009014 FAD binding motif [chemical binding]; other site 568707009015 phosphate binding motif [ion binding]; other site 568707009016 beta-alpha-beta structure motif; other site 568707009017 NAD binding pocket [chemical binding]; other site 568707009018 DctM-like transporters; Region: DctM; pfam06808 568707009019 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 568707009020 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707009021 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707009022 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 568707009023 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 568707009024 [2Fe-2S] cluster binding site [ion binding]; other site 568707009025 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 568707009026 alpha subunit interface [polypeptide binding]; other site 568707009027 active site 568707009028 substrate binding site [chemical binding]; other site 568707009029 Fe binding site [ion binding]; other site 568707009030 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707009031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707009032 putative DNA binding site [nucleotide binding]; other site 568707009033 putative Zn2+ binding site [ion binding]; other site 568707009034 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707009035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 568707009036 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009037 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 568707009038 active site 568707009039 catalytic residues [active] 568707009040 metal binding site [ion binding]; metal-binding site 568707009041 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707009042 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707009043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707009044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707009045 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 568707009046 putative dimerization interface [polypeptide binding]; other site 568707009047 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 568707009048 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 568707009049 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 568707009050 thiS-thiF/thiG interaction site; other site 568707009051 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 568707009052 BON domain; Region: BON; pfam04972 568707009053 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568707009054 signal recognition particle protein; Provisional; Region: PRK10867 568707009055 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 568707009056 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 568707009057 GTP binding site [chemical binding]; other site 568707009058 Signal peptide binding domain; Region: SRP_SPB; pfam02978 568707009059 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 568707009060 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 568707009061 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 568707009062 amidase catalytic site [active] 568707009063 Zn binding residues [ion binding]; other site 568707009064 substrate binding site [chemical binding]; other site 568707009065 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 568707009066 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 568707009067 putative C-terminal domain interface [polypeptide binding]; other site 568707009068 putative GSH binding site (G-site) [chemical binding]; other site 568707009069 putative dimer interface [polypeptide binding]; other site 568707009070 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 568707009071 putative N-terminal domain interface [polypeptide binding]; other site 568707009072 putative dimer interface [polypeptide binding]; other site 568707009073 putative substrate binding pocket (H-site) [chemical binding]; other site 568707009074 heat shock protein 90; Provisional; Region: PRK05218 568707009075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707009076 ATP binding site [chemical binding]; other site 568707009077 Mg2+ binding site [ion binding]; other site 568707009078 G-X-G motif; other site 568707009080 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 568707009081 DEAD-like helicases superfamily; Region: DEXDc; smart00487 568707009082 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568707009083 ATP binding site [chemical binding]; other site 568707009084 putative Mg++ binding site [ion binding]; other site 568707009085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568707009086 nucleotide binding region [chemical binding]; other site 568707009087 ATP-binding site [chemical binding]; other site 568707009088 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 568707009089 active site 568707009090 metal binding site [ion binding]; metal-binding site 568707009092 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 568707009093 FIC domain binding interface [polypeptide binding]; other site 568707009094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707009095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707009096 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 568707009097 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 568707009098 homodimer interface [polypeptide binding]; other site 568707009099 active site 568707009100 TDP-binding site; other site 568707009101 acceptor substrate-binding pocket; other site 568707009102 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 568707009103 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 568707009104 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 568707009105 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 568707009106 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 568707009107 active site 568707009108 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009109 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009110 Sulfatase; Region: Sulfatase; cl17466 568707009111 choline-sulfatase; Region: chol_sulfatase; TIGR03417 568707009112 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 568707009113 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707009115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707009116 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 568707009117 putative dimerization interface [polypeptide binding]; other site 568707009118 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568707009119 DNA-binding site [nucleotide binding]; DNA binding site 568707009120 RNA-binding motif; other site 568707009121 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707009122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707009123 DNA-binding site [nucleotide binding]; DNA binding site 568707009124 FCD domain; Region: FCD; pfam07729 568707009125 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 568707009126 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 568707009127 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 568707009128 molybdopterin cofactor binding site; other site 568707009129 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 568707009130 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 568707009131 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 568707009132 putative molybdopterin cofactor binding site; other site 568707009133 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 568707009134 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 568707009135 FAD binding pocket [chemical binding]; other site 568707009136 FAD binding motif [chemical binding]; other site 568707009137 phosphate binding motif [ion binding]; other site 568707009138 beta-alpha-beta structure motif; other site 568707009139 NAD binding pocket [chemical binding]; other site 568707009140 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707009141 catalytic loop [active] 568707009142 iron binding site [ion binding]; other site 568707009143 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 568707009144 homotrimer interaction site [polypeptide binding]; other site 568707009145 putative active site [active] 568707009146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707009147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707009148 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 568707009149 putative effector binding pocket; other site 568707009150 putative dimerization interface [polypeptide binding]; other site 568707009151 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009152 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 568707009153 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707009154 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 568707009155 putative active site [active] 568707009156 putative catalytic site [active] 568707009157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707009158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707009159 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 568707009160 putative dimerization interface [polypeptide binding]; other site 568707009161 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707009162 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707009163 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 568707009164 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 568707009165 NADP binding site [chemical binding]; other site 568707009166 dimer interface [polypeptide binding]; other site 568707009167 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009168 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 568707009169 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707009170 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707009171 substrate binding site [chemical binding]; other site 568707009172 oxyanion hole (OAH) forming residues; other site 568707009173 trimer interface [polypeptide binding]; other site 568707009174 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707009175 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707009176 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707009177 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 568707009178 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707009179 acyl-activating enzyme (AAE) consensus motif; other site 568707009180 AMP binding site [chemical binding]; other site 568707009181 active site 568707009182 CoA binding site [chemical binding]; other site 568707009183 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009184 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 568707009185 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009186 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009187 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009188 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009189 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009190 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009191 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009192 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009193 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009194 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009195 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009196 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009197 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 568707009198 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568707009199 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707009200 Predicted small secreted protein [Function unknown]; Region: COG5510 568707009201 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009202 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009203 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009204 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009205 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009206 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009207 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009208 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009209 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009210 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009211 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009212 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009213 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 568707009214 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 568707009215 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707009216 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 568707009217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707009218 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707009219 dimerization interface [polypeptide binding]; other site 568707009220 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 568707009221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707009222 motif II; other site 568707009223 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 568707009224 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 568707009225 dimer interface [polypeptide binding]; other site 568707009226 active site 568707009227 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568707009228 substrate binding site [chemical binding]; other site 568707009229 catalytic residue [active] 568707009230 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 568707009231 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 568707009232 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 568707009233 SPFH domain / Band 7 family; Region: Band_7; pfam01145 568707009234 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 568707009235 GSH binding site (G-site) [chemical binding]; other site 568707009236 C-terminal domain interface [polypeptide binding]; other site 568707009237 dimer interface [polypeptide binding]; other site 568707009238 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 568707009239 dimer interface [polypeptide binding]; other site 568707009240 N-terminal domain interface [polypeptide binding]; other site 568707009241 substrate binding pocket (H-site) [chemical binding]; other site 568707009242 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568707009243 homotrimer interaction site [polypeptide binding]; other site 568707009244 putative active site [active] 568707009245 voltage-gated potassium channel; Provisional; Region: PRK10537 568707009246 Ion channel; Region: Ion_trans_2; pfam07885 568707009247 TrkA-N domain; Region: TrkA_N; pfam02254 568707009248 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 568707009249 Domain of unknown function DUF20; Region: UPF0118; pfam01594 568707009250 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568707009251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707009252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707009253 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 568707009254 putative effector binding pocket; other site 568707009255 putative dimerization interface [polypeptide binding]; other site 568707009256 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568707009257 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568707009258 HlyD family secretion protein; Region: HlyD_3; pfam13437 568707009259 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 568707009260 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 568707009261 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 568707009262 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 568707009263 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 568707009264 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 568707009265 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 568707009266 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 568707009267 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 568707009268 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 568707009269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707009270 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 568707009271 active site 568707009272 catalytic residues [active] 568707009273 metal binding site [ion binding]; metal-binding site 568707009274 Cupin domain; Region: Cupin_2; pfam07883 568707009275 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568707009276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707009278 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568707009279 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 568707009280 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 568707009281 putative ligand binding site [chemical binding]; other site 568707009282 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 568707009283 NAD binding site [chemical binding]; other site 568707009284 dimerization interface [polypeptide binding]; other site 568707009285 catalytic site [active] 568707009286 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 568707009287 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 568707009288 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 568707009289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707009290 Coenzyme A binding pocket [chemical binding]; other site 568707009291 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 568707009292 Ligand Binding Site [chemical binding]; other site 568707009293 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 568707009294 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 568707009295 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 568707009296 catalytic triad [active] 568707009297 putative active site [active] 568707009298 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 568707009299 catalytic residues [active] 568707009300 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 568707009301 Autotransporter beta-domain; Region: Autotransporter; smart00869 568707009302 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 568707009303 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568707009304 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568707009305 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 568707009306 short chain dehydrogenase; Provisional; Region: PRK07577 568707009307 classical (c) SDRs; Region: SDR_c; cd05233 568707009308 NAD(P) binding site [chemical binding]; other site 568707009309 active site 568707009310 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 568707009311 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707009312 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707009313 Coenzyme A transferase; Region: CoA_trans; cl17247 568707009314 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 568707009315 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 568707009316 YciI-like protein; Reviewed; Region: PRK12863 568707009317 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 568707009318 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568707009319 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 568707009320 Putative cyclase; Region: Cyclase; pfam04199 568707009321 psiF repeat; Region: PsiF_repeat; pfam07769 568707009322 psiF repeat; Region: PsiF_repeat; pfam07769 568707009323 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 568707009324 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 568707009325 active site clefts [active] 568707009326 zinc binding site [ion binding]; other site 568707009327 dimer interface [polypeptide binding]; other site 568707009328 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568707009329 Amidase; Region: Amidase; pfam01425 568707009330 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707009331 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 568707009332 putative ligand binding site [chemical binding]; other site 568707009333 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 568707009334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707009335 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 568707009336 putative dimerization interface [polypeptide binding]; other site 568707009337 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707009338 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707009339 TM-ABC transporter signature motif; other site 568707009340 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707009341 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707009342 TM-ABC transporter signature motif; other site 568707009343 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707009344 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707009345 Walker A/P-loop; other site 568707009346 ATP binding site [chemical binding]; other site 568707009347 Q-loop/lid; other site 568707009348 ABC transporter signature motif; other site 568707009349 Walker B; other site 568707009350 D-loop; other site 568707009351 H-loop/switch region; other site 568707009352 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707009353 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707009354 Walker A/P-loop; other site 568707009355 ATP binding site [chemical binding]; other site 568707009356 Q-loop/lid; other site 568707009357 ABC transporter signature motif; other site 568707009358 Walker B; other site 568707009359 D-loop; other site 568707009360 H-loop/switch region; other site 568707009361 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 568707009362 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 568707009363 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 568707009364 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 568707009365 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 568707009366 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 568707009367 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568707009368 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 568707009369 putative hydrophobic ligand binding site [chemical binding]; other site 568707009370 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 568707009371 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 568707009372 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 568707009373 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 568707009374 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 568707009375 catalytic loop [active] 568707009376 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 568707009377 iron binding site [ion binding]; other site 568707009378 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 568707009379 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 568707009380 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 568707009381 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 568707009382 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009383 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 568707009384 Flavoprotein; Region: Flavoprotein; pfam02441 568707009385 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 568707009386 putative GSH binding site [chemical binding]; other site 568707009387 catalytic residues [active] 568707009388 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 568707009389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707009390 S-adenosylmethionine binding site [chemical binding]; other site 568707009391 peptide chain release factor 1; Validated; Region: prfA; PRK00591 568707009392 This domain is found in peptide chain release factors; Region: PCRF; smart00937 568707009393 RF-1 domain; Region: RF-1; pfam00472 568707009394 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 568707009395 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 568707009396 tRNA; other site 568707009397 putative tRNA binding site [nucleotide binding]; other site 568707009398 putative NADP binding site [chemical binding]; other site 568707009399 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 568707009400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568707009401 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 568707009402 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 568707009403 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 568707009404 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568707009405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707009406 active site 568707009407 phosphorylation site [posttranslational modification] 568707009408 intermolecular recognition site; other site 568707009409 dimerization interface [polypeptide binding]; other site 568707009410 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707009411 DNA binding site [nucleotide binding] 568707009412 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568707009413 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707009414 dimerization interface [polypeptide binding]; other site 568707009415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707009416 dimer interface [polypeptide binding]; other site 568707009417 phosphorylation site [posttranslational modification] 568707009418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707009419 ATP binding site [chemical binding]; other site 568707009420 Mg2+ binding site [ion binding]; other site 568707009421 G-X-G motif; other site 568707009422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 568707009423 Uncharacterized conserved protein [Function unknown]; Region: COG1434 568707009424 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568707009425 putative active site [active] 568707009426 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568707009427 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 568707009428 active site 568707009429 FMN binding site [chemical binding]; other site 568707009430 substrate binding site [chemical binding]; other site 568707009431 homotetramer interface [polypeptide binding]; other site 568707009432 catalytic residue [active] 568707009433 short chain dehydrogenase; Provisional; Region: PRK06125 568707009434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707009435 NAD(P) binding site [chemical binding]; other site 568707009436 active site 568707009437 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 568707009438 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 568707009439 classical (c) SDRs; Region: SDR_c; cd05233 568707009440 NAD(P) binding site [chemical binding]; other site 568707009441 active site 568707009442 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707009443 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707009444 Walker A/P-loop; other site 568707009445 ATP binding site [chemical binding]; other site 568707009446 Q-loop/lid; other site 568707009447 ABC transporter signature motif; other site 568707009448 Walker B; other site 568707009449 D-loop; other site 568707009450 H-loop/switch region; other site 568707009451 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707009452 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707009453 Walker A/P-loop; other site 568707009454 ATP binding site [chemical binding]; other site 568707009455 Q-loop/lid; other site 568707009456 ABC transporter signature motif; other site 568707009457 Walker B; other site 568707009458 D-loop; other site 568707009459 H-loop/switch region; other site 568707009460 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707009461 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707009462 TM-ABC transporter signature motif; other site 568707009463 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707009464 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707009465 TM-ABC transporter signature motif; other site 568707009466 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707009467 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 568707009468 putative ligand binding site [chemical binding]; other site 568707009469 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 568707009470 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568707009471 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707009472 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707009473 substrate binding site [chemical binding]; other site 568707009474 oxyanion hole (OAH) forming residues; other site 568707009475 trimer interface [polypeptide binding]; other site 568707009476 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707009477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707009478 LysR substrate binding domain; Region: LysR_substrate; pfam03466 568707009479 dimerization interface [polypeptide binding]; other site 568707009480 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 568707009481 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 568707009482 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707009483 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 568707009484 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707009485 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568707009486 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568707009487 active site 568707009488 metal binding site [ion binding]; metal-binding site 568707009489 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009490 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009491 fumarate hydratase; Provisional; Region: PRK06246 568707009492 Fumarase C-terminus; Region: Fumerase_C; cl00795 568707009493 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707009494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707009495 DNA-binding site [nucleotide binding]; DNA binding site 568707009496 UTRA domain; Region: UTRA; pfam07702 568707009497 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 568707009498 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707009499 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707009500 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 568707009501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707009502 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 568707009503 putative dimerization interface [polypeptide binding]; other site 568707009504 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 568707009505 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568707009506 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 568707009507 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707009508 PYR/PP interface [polypeptide binding]; other site 568707009509 dimer interface [polypeptide binding]; other site 568707009510 TPP binding site [chemical binding]; other site 568707009511 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707009512 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 568707009513 TPP-binding site [chemical binding]; other site 568707009514 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 568707009515 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568707009516 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 568707009517 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707009518 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707009519 Walker A/P-loop; other site 568707009520 ATP binding site [chemical binding]; other site 568707009521 Q-loop/lid; other site 568707009522 ABC transporter signature motif; other site 568707009523 Walker B; other site 568707009524 D-loop; other site 568707009525 H-loop/switch region; other site 568707009526 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707009527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707009528 dimer interface [polypeptide binding]; other site 568707009529 conserved gate region; other site 568707009530 putative PBP binding loops; other site 568707009531 ABC-ATPase subunit interface; other site 568707009532 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 568707009533 putative active site [active] 568707009534 Zn binding site [ion binding]; other site 568707009535 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 568707009536 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707009537 acyl-activating enzyme (AAE) consensus motif; other site 568707009538 AMP binding site [chemical binding]; other site 568707009539 active site 568707009540 CoA binding site [chemical binding]; other site 568707009541 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 568707009542 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 568707009543 NAD(P) binding site [chemical binding]; other site 568707009544 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707009545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707009546 DNA-binding site [nucleotide binding]; DNA binding site 568707009547 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568707009548 Autotransporter beta-domain; Region: Autotransporter; pfam03797 568707009549 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707009550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707009551 DNA-binding site [nucleotide binding]; DNA binding site 568707009552 FCD domain; Region: FCD; pfam07729 568707009553 acetolactate synthase catalytic subunit; Validated; Region: PRK06112 568707009554 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707009555 PYR/PP interface [polypeptide binding]; other site 568707009556 dimer interface [polypeptide binding]; other site 568707009557 TPP binding site [chemical binding]; other site 568707009558 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707009559 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 568707009560 TPP-binding site [chemical binding]; other site 568707009561 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 568707009562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707009563 NAD(P) binding site [chemical binding]; other site 568707009564 active site 568707009565 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009566 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 568707009567 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 568707009568 homodimer interface [polypeptide binding]; other site 568707009569 substrate-cofactor binding pocket; other site 568707009570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707009571 catalytic residue [active] 568707009572 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568707009573 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568707009574 Walker A/P-loop; other site 568707009575 ATP binding site [chemical binding]; other site 568707009576 Q-loop/lid; other site 568707009577 ABC transporter signature motif; other site 568707009578 Walker B; other site 568707009579 D-loop; other site 568707009580 H-loop/switch region; other site 568707009581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 568707009582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707009583 putative PBP binding loops; other site 568707009584 ABC-ATPase subunit interface; other site 568707009585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707009586 dimer interface [polypeptide binding]; other site 568707009587 conserved gate region; other site 568707009588 putative PBP binding loops; other site 568707009589 ABC-ATPase subunit interface; other site 568707009590 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707009591 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568707009592 substrate binding pocket [chemical binding]; other site 568707009593 membrane-bound complex binding site; other site 568707009594 hinge residues; other site 568707009595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707009596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707009597 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707009598 dimerization interface [polypeptide binding]; other site 568707009599 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568707009600 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 568707009601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707009602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707009603 dimer interface [polypeptide binding]; other site 568707009604 conserved gate region; other site 568707009605 putative PBP binding loops; other site 568707009606 ABC-ATPase subunit interface; other site 568707009607 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568707009608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707009609 dimer interface [polypeptide binding]; other site 568707009610 conserved gate region; other site 568707009611 putative PBP binding loops; other site 568707009612 ABC-ATPase subunit interface; other site 568707009613 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568707009614 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707009615 Walker A/P-loop; other site 568707009616 ATP binding site [chemical binding]; other site 568707009617 Q-loop/lid; other site 568707009618 ABC transporter signature motif; other site 568707009619 Walker B; other site 568707009620 D-loop; other site 568707009621 H-loop/switch region; other site 568707009622 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707009623 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 568707009624 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707009625 Walker A/P-loop; other site 568707009626 ATP binding site [chemical binding]; other site 568707009627 Q-loop/lid; other site 568707009628 ABC transporter signature motif; other site 568707009629 Walker B; other site 568707009630 D-loop; other site 568707009631 H-loop/switch region; other site 568707009632 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707009633 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 568707009634 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 568707009635 dimer interface [polypeptide binding]; other site 568707009636 active site 568707009637 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568707009638 substrate binding site [chemical binding]; other site 568707009639 catalytic residue [active] 568707009640 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568707009641 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568707009642 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568707009643 putative active site [active] 568707009644 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 568707009645 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 568707009646 active site 568707009647 putative substrate binding pocket [chemical binding]; other site 568707009648 succinic semialdehyde dehydrogenase; Region: PLN02278 568707009649 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 568707009650 tetramerization interface [polypeptide binding]; other site 568707009651 NAD(P) binding site [chemical binding]; other site 568707009652 catalytic residues [active] 568707009653 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009654 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568707009655 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 568707009656 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 568707009657 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 568707009658 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 568707009659 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 568707009660 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 568707009661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707009662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707009663 dimerization interface [polypeptide binding]; other site 568707009664 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568707009665 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568707009666 substrate binding pocket [chemical binding]; other site 568707009667 chain length determination region; other site 568707009668 substrate-Mg2+ binding site; other site 568707009669 catalytic residues [active] 568707009670 aspartate-rich region 1; other site 568707009671 active site lid residues [active] 568707009672 aspartate-rich region 2; other site 568707009673 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 568707009674 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568707009675 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 568707009676 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 568707009677 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 568707009678 GTPase CgtA; Reviewed; Region: obgE; PRK12299 568707009679 GTP1/OBG; Region: GTP1_OBG; pfam01018 568707009680 Obg GTPase; Region: Obg; cd01898 568707009681 G1 box; other site 568707009682 GTP/Mg2+ binding site [chemical binding]; other site 568707009683 Switch I region; other site 568707009684 G2 box; other site 568707009685 G3 box; other site 568707009686 Switch II region; other site 568707009687 G4 box; other site 568707009688 G5 box; other site 568707009689 gamma-glutamyl kinase; Provisional; Region: PRK05429 568707009690 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 568707009691 nucleotide binding site [chemical binding]; other site 568707009692 homotetrameric interface [polypeptide binding]; other site 568707009693 putative phosphate binding site [ion binding]; other site 568707009694 putative allosteric binding site; other site 568707009695 PUA domain; Region: PUA; pfam01472 568707009696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568707009697 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 568707009698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707009699 non-specific DNA binding site [nucleotide binding]; other site 568707009700 salt bridge; other site 568707009701 sequence-specific DNA binding site [nucleotide binding]; other site 568707009702 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707009703 non-specific DNA binding site [nucleotide binding]; other site 568707009704 salt bridge; other site 568707009705 sequence-specific DNA binding site [nucleotide binding]; other site 568707009706 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 568707009707 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 568707009708 Methyltransferase domain; Region: Methyltransf_11; pfam08241 568707009709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 568707009710 HindIII restriction endonuclease; Region: RE_HindIII; pfam09518 568707009711 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 568707009712 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 568707009713 ThiC-associated domain; Region: ThiC-associated; pfam13667 568707009714 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 568707009715 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 568707009716 FAD binding domain; Region: FAD_binding_4; pfam01565 568707009717 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568707009718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707009719 DNA-binding site [nucleotide binding]; DNA binding site 568707009720 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568707009721 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 568707009722 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 568707009723 ATP binding site [chemical binding]; other site 568707009724 substrate interface [chemical binding]; other site 568707009725 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 568707009726 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 568707009727 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 568707009728 protein binding site [polypeptide binding]; other site 568707009729 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 568707009730 Catalytic dyad [active] 568707009731 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 568707009732 Peptidase family M23; Region: Peptidase_M23; pfam01551 568707009733 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568707009734 catalytic core [active] 568707009735 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568707009736 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568707009737 active site residue [active] 568707009738 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 568707009739 GSH binding site [chemical binding]; other site 568707009740 catalytic residues [active] 568707009741 preprotein translocase subunit SecB; Validated; Region: PRK05751 568707009742 SecA binding site; other site 568707009743 Preprotein binding site; other site 568707009744 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 568707009745 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 568707009746 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 568707009747 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009748 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 568707009749 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 568707009750 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 568707009751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707009752 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 568707009753 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 568707009754 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 568707009755 DctM-like transporters; Region: DctM; pfam06808 568707009756 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 568707009757 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 568707009759 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707009760 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707009761 Walker A/P-loop; other site 568707009762 ATP binding site [chemical binding]; other site 568707009763 Q-loop/lid; other site 568707009764 ABC transporter signature motif; other site 568707009765 Walker B; other site 568707009766 D-loop; other site 568707009767 H-loop/switch region; other site 568707009768 NMT1/THI5 like; Region: NMT1; pfam09084 568707009769 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 568707009770 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 568707009771 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707009772 catalytic loop [active] 568707009773 iron binding site [ion binding]; other site 568707009774 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 568707009775 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 568707009776 putative hydrophobic ligand binding site [chemical binding]; other site 568707009777 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 568707009778 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 568707009779 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 568707009780 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 568707009781 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 568707009782 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707009783 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 568707009784 [2Fe-2S] cluster binding site [ion binding]; other site 568707009785 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 568707009786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707009787 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 568707009788 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 568707009789 iron-sulfur cluster [ion binding]; other site 568707009790 [2Fe-2S] cluster binding site [ion binding]; other site 568707009791 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 568707009792 putative alpha subunit interface [polypeptide binding]; other site 568707009793 putative active site [active] 568707009794 putative substrate binding site [chemical binding]; other site 568707009795 Fe binding site [ion binding]; other site 568707009796 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 568707009797 inter-subunit interface; other site 568707009798 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 568707009799 Isochorismatase family; Region: Isochorismatase; pfam00857 568707009800 catalytic triad [active] 568707009801 conserved cis-peptide bond; other site 568707009802 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 568707009803 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568707009804 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 568707009805 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 568707009806 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 568707009807 Ligand binding site; other site 568707009808 metal-binding site 568707009809 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 568707009810 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 568707009811 XdhC Rossmann domain; Region: XdhC_C; pfam13478 568707009812 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568707009813 MarR family; Region: MarR_2; pfam12802 568707009814 Cation transport protein; Region: TrkH; cl17365 568707009815 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 568707009816 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 568707009817 TrkA-N domain; Region: TrkA_N; pfam02254 568707009818 TrkA-C domain; Region: TrkA_C; pfam02080 568707009819 TrkA-N domain; Region: TrkA_N; pfam02254 568707009820 TrkA-C domain; Region: TrkA_C; pfam02080 568707009821 Response regulator receiver domain; Region: Response_reg; pfam00072 568707009822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707009823 active site 568707009824 phosphorylation site [posttranslational modification] 568707009825 intermolecular recognition site; other site 568707009826 dimerization interface [polypeptide binding]; other site 568707009827 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 568707009828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707009829 dimerization interface [polypeptide binding]; other site 568707009830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707009831 dimer interface [polypeptide binding]; other site 568707009832 phosphorylation site [posttranslational modification] 568707009833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707009834 ATP binding site [chemical binding]; other site 568707009835 Mg2+ binding site [ion binding]; other site 568707009836 G-X-G motif; other site 568707009837 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 568707009838 16S rRNA methyltransferase B; Provisional; Region: PRK10901 568707009839 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 568707009840 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 568707009841 L-aspartate dehydrogenase; Provisional; Region: PRK13303 568707009842 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 568707009843 Domain of unknown function DUF108; Region: DUF108; pfam01958 568707009844 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 568707009845 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707009846 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707009847 DNA-binding site [nucleotide binding]; DNA binding site 568707009848 FCD domain; Region: FCD; pfam07729 568707009849 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009850 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568707009851 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 568707009852 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 568707009853 active site 1 [active] 568707009854 dimer interface [polypeptide binding]; other site 568707009855 hexamer interface [polypeptide binding]; other site 568707009856 active site 2 [active] 568707009857 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 568707009858 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 568707009859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568707009860 FeS/SAM binding site; other site 568707009861 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 568707009862 Ferritin-like domain; Region: Ferritin; pfam00210 568707009863 dinuclear metal binding motif [ion binding]; other site 568707009864 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 568707009865 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 568707009866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707009867 motif II; other site 568707009868 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 568707009869 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 568707009870 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 568707009871 putative active site [active] 568707009872 substrate binding site [chemical binding]; other site 568707009873 putative cosubstrate binding site; other site 568707009874 catalytic site [active] 568707009875 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 568707009876 substrate binding site [chemical binding]; other site 568707009877 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 568707009878 active site 568707009879 catalytic residues [active] 568707009880 metal binding site [ion binding]; metal-binding site 568707009882 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568707009883 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707009884 putative DNA binding site [nucleotide binding]; other site 568707009885 putative Zn2+ binding site [ion binding]; other site 568707009886 AsnC family; Region: AsnC_trans_reg; pfam01037 568707009887 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 568707009888 DNA protecting protein DprA; Region: dprA; TIGR00732 568707009889 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 568707009890 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 568707009891 active site 568707009892 catalytic residues [active] 568707009893 metal binding site [ion binding]; metal-binding site 568707009894 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 568707009895 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 568707009896 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707009897 substrate binding pocket [chemical binding]; other site 568707009898 membrane-bound complex binding site; other site 568707009899 hinge residues; other site 568707009900 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707009901 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 568707009902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707009903 homodimer interface [polypeptide binding]; other site 568707009904 catalytic residue [active] 568707009905 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 568707009906 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568707009907 catalytic residue [active] 568707009908 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707009909 Protein of unknown function (DUF461); Region: DUF461; pfam04314 568707009910 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 568707009911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707009912 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707009913 dimerization interface [polypeptide binding]; other site 568707009914 LysE type translocator; Region: LysE; cl00565 568707009915 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568707009916 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568707009917 ligand binding site [chemical binding]; other site 568707009918 flexible hinge region; other site 568707009919 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 568707009920 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 568707009921 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707009922 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 568707009923 acyl-activating enzyme (AAE) consensus motif; other site 568707009924 putative AMP binding site [chemical binding]; other site 568707009925 putative active site [active] 568707009926 putative CoA binding site [chemical binding]; other site 568707009927 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707009928 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707009929 Walker A/P-loop; other site 568707009930 ATP binding site [chemical binding]; other site 568707009931 Q-loop/lid; other site 568707009932 ABC transporter signature motif; other site 568707009933 Walker B; other site 568707009934 D-loop; other site 568707009935 H-loop/switch region; other site 568707009936 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707009937 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707009938 TM-ABC transporter signature motif; other site 568707009939 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707009940 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707009941 TM-ABC transporter signature motif; other site 568707009942 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 568707009943 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707009944 putative ligand binding site [chemical binding]; other site 568707009945 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707009946 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707009947 Walker A/P-loop; other site 568707009948 ATP binding site [chemical binding]; other site 568707009949 Q-loop/lid; other site 568707009950 ABC transporter signature motif; other site 568707009951 Walker B; other site 568707009952 D-loop; other site 568707009953 H-loop/switch region; other site 568707009954 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 568707009955 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707009956 acyl-activating enzyme (AAE) consensus motif; other site 568707009957 active site 568707009958 AMP binding site [chemical binding]; other site 568707009959 CoA binding site [chemical binding]; other site 568707009960 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 568707009961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707009962 putative DNA binding site [nucleotide binding]; other site 568707009963 putative Zn2+ binding site [ion binding]; other site 568707009964 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 568707009965 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 568707009966 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 568707009967 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 568707009968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707009969 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568707009970 Coenzyme A binding pocket [chemical binding]; other site 568707009971 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 568707009972 nucleotide binding site/active site [active] 568707009973 HIT family signature motif; other site 568707009974 catalytic residue [active] 568707009975 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568707009976 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707009977 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 568707009978 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 568707009979 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 568707009980 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 568707009981 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 568707009982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707009983 motif II; other site 568707009984 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 568707009985 ligand binding site [chemical binding]; other site 568707009986 active site 568707009987 UGI interface [polypeptide binding]; other site 568707009988 catalytic site [active] 568707009989 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 568707009990 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568707009991 ATP binding site [chemical binding]; other site 568707009992 Mg++ binding site [ion binding]; other site 568707009993 motif III; other site 568707009994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568707009995 nucleotide binding region [chemical binding]; other site 568707009996 ATP-binding site [chemical binding]; other site 568707009997 Uncharacterized conserved protein [Function unknown]; Region: COG1565 568707009998 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13297 568707009999 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 568707010000 active site 568707010001 NTP binding site [chemical binding]; other site 568707010002 metal binding triad [ion binding]; metal-binding site 568707010003 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 568707010004 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 568707010005 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568707010006 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568707010007 catalytic residue [active] 568707010008 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 568707010009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707010010 metabolite-proton symporter; Region: 2A0106; TIGR00883 568707010011 putative substrate translocation pore; other site 568707010012 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 568707010013 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 568707010014 active site 568707010015 Zn binding site [ion binding]; other site 568707010016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707010017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707010018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707010019 dimerization interface [polypeptide binding]; other site 568707010020 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 568707010021 FAD binding site [chemical binding]; other site 568707010022 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 568707010023 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 568707010024 homotetramer interface [polypeptide binding]; other site 568707010025 ligand binding site [chemical binding]; other site 568707010026 catalytic site [active] 568707010027 NAD binding site [chemical binding]; other site 568707010028 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707010029 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 568707010030 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 568707010031 S-adenosylmethionine synthetase; Validated; Region: PRK05250 568707010032 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 568707010033 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 568707010034 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 568707010035 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 568707010036 putative acyl-acceptor binding pocket; other site 568707010037 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 568707010038 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 568707010039 putative acyl-acceptor binding pocket; other site 568707010040 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 568707010041 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 568707010042 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 568707010043 Protein of unknown function, DUF484; Region: DUF484; cl17449 568707010044 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 568707010045 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568707010046 active site 568707010047 DNA binding site [nucleotide binding] 568707010048 Int/Topo IB signature motif; other site 568707010050 High-affinity nickel-transport protein; Region: NicO; cl00964 568707010051 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 568707010052 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 568707010053 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 568707010054 metal binding site [ion binding]; metal-binding site 568707010055 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 568707010056 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 568707010057 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 568707010058 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 568707010059 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568707010060 metal binding site 2 [ion binding]; metal-binding site 568707010061 putative DNA binding helix; other site 568707010062 metal binding site 1 [ion binding]; metal-binding site 568707010063 dimer interface [polypeptide binding]; other site 568707010064 structural Zn2+ binding site [ion binding]; other site 568707010065 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 568707010066 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 568707010067 P-loop, Walker A motif; other site 568707010068 Base recognition motif; other site 568707010069 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 568707010070 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 568707010071 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 568707010072 active site 568707010073 HslU subunit interaction site [polypeptide binding]; other site 568707010074 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 568707010075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707010076 Walker A motif; other site 568707010077 ATP binding site [chemical binding]; other site 568707010078 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 568707010079 Walker B motif; other site 568707010080 arginine finger; other site 568707010081 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 568707010082 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 568707010083 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 568707010084 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 568707010085 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 568707010086 NAD binding site [chemical binding]; other site 568707010087 substrate binding site [chemical binding]; other site 568707010088 homodimer interface [polypeptide binding]; other site 568707010089 active site 568707010090 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 568707010091 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 568707010092 NADP binding site [chemical binding]; other site 568707010093 active site 568707010094 putative substrate binding site [chemical binding]; other site 568707010095 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 568707010096 lipoyl synthase; Provisional; Region: PRK05481 568707010097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 568707010098 FeS/SAM binding site; other site 568707010099 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 568707010100 hypothetical protein; Provisional; Region: PRK02047 568707010101 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 568707010102 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 568707010103 homodimer interface [polypeptide binding]; other site 568707010104 substrate-cofactor binding pocket; other site 568707010105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707010106 catalytic residue [active] 568707010107 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 568707010108 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 568707010109 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 568707010110 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 568707010111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 568707010112 Protein of unknown function (DUF330); Region: DUF330; cl01135 568707010113 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 568707010114 mce related protein; Region: MCE; pfam02470 568707010115 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 568707010116 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 568707010117 Walker A/P-loop; other site 568707010118 ATP binding site [chemical binding]; other site 568707010119 Q-loop/lid; other site 568707010120 ABC transporter signature motif; other site 568707010121 Walker B; other site 568707010122 D-loop; other site 568707010123 H-loop/switch region; other site 568707010124 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 568707010125 Permease; Region: Permease; pfam02405 568707010126 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 568707010127 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 568707010128 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 568707010129 pantothenate kinase; Reviewed; Region: PRK13328 568707010130 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 568707010131 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 568707010132 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568707010133 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 568707010134 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 568707010135 putative active site [active] 568707010136 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568707010137 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568707010138 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568707010139 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 568707010140 putative CoA binding site [chemical binding]; other site 568707010141 putative trimer interface [polypeptide binding]; other site 568707010142 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 568707010143 putative trimer interface [polypeptide binding]; other site 568707010144 putative active site [active] 568707010145 putative substrate binding site [chemical binding]; other site 568707010146 putative CoA binding site [chemical binding]; other site 568707010147 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 568707010148 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 568707010149 inhibitor-cofactor binding pocket; inhibition site 568707010150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707010151 catalytic residue [active] 568707010152 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 568707010153 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 568707010154 homodimer interface [polypeptide binding]; other site 568707010155 active site 568707010156 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707010157 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 568707010158 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 568707010159 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 568707010160 inhibitor-cofactor binding pocket; inhibition site 568707010161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707010162 catalytic residue [active] 568707010163 Bacterial sugar transferase; Region: Bac_transf; pfam02397 568707010164 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 568707010165 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707010166 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 568707010167 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 568707010168 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 568707010169 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 568707010170 NAD(P) binding site [chemical binding]; other site 568707010171 homodimer interface [polypeptide binding]; other site 568707010172 substrate binding site [chemical binding]; other site 568707010173 active site 568707010174 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707010175 This family is most closely related to the GT1 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose...; Region: GT1_AmsK_like; cd04946 568707010176 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568707010177 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 568707010178 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 568707010179 active site 568707010180 dimer interface [polypeptide binding]; other site 568707010181 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 568707010182 Ligand Binding Site [chemical binding]; other site 568707010183 Molecular Tunnel; other site 568707010184 Transglutaminase/protease-like homologues; Region: TGc; smart00460 568707010185 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 568707010186 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568707010187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707010188 NAD(P) binding site [chemical binding]; other site 568707010189 active site 568707010190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707010191 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568707010192 NAD(P) binding site [chemical binding]; other site 568707010193 active site 568707010194 Bordetella bronchiseptica enzymes WbmH and WbmG-like, extended (e) SDRs; Region: WbmH_like_SDR_e; cd08957 568707010195 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568707010196 NAD binding site [chemical binding]; other site 568707010197 homodimer interface [polypeptide binding]; other site 568707010198 active site 568707010199 putative substrate binding site [chemical binding]; other site 568707010200 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 568707010201 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 568707010202 active site 568707010203 dimer interface [polypeptide binding]; other site 568707010204 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 568707010205 Ligand Binding Site [chemical binding]; other site 568707010206 Molecular Tunnel; other site 568707010207 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568707010208 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707010209 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568707010210 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 568707010211 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 568707010212 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 568707010213 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 568707010214 Walker A/P-loop; other site 568707010215 ATP binding site [chemical binding]; other site 568707010216 Q-loop/lid; other site 568707010217 ABC transporter signature motif; other site 568707010218 Walker B; other site 568707010219 D-loop; other site 568707010220 H-loop/switch region; other site 568707010221 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 568707010222 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 568707010223 Walker A/P-loop; other site 568707010224 ATP binding site [chemical binding]; other site 568707010225 Q-loop/lid; other site 568707010226 ABC transporter signature motif; other site 568707010227 Walker B; other site 568707010228 D-loop; other site 568707010229 H-loop/switch region; other site 568707010230 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 568707010231 putative carbohydrate binding site [chemical binding]; other site 568707010232 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 568707010233 WbqC-like protein family; Region: WbqC; pfam08889 568707010234 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 568707010235 substrate binding site [chemical binding]; other site 568707010236 active site 568707010237 cosubstrate binding site; other site 568707010238 catalytic site [active] 568707010239 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 568707010240 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 568707010241 active site 568707010242 substrate binding site [chemical binding]; other site 568707010243 cosubstrate binding site; other site 568707010244 catalytic site [active] 568707010245 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 568707010246 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 568707010247 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 568707010248 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 568707010249 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 568707010250 active site 568707010251 substrate binding site [chemical binding]; other site 568707010252 cosubstrate binding site; other site 568707010253 catalytic site [active] 568707010254 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 568707010255 active site 568707010256 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 568707010257 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 568707010258 dimer interface [polypeptide binding]; other site 568707010259 active site 568707010260 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 568707010261 Ligand Binding Site [chemical binding]; other site 568707010262 Molecular Tunnel; other site 568707010263 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 568707010264 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 568707010265 inhibitor-cofactor binding pocket; inhibition site 568707010266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707010267 catalytic residue [active] 568707010268 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568707010269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707010270 NAD(P) binding site [chemical binding]; other site 568707010271 active site 568707010272 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 568707010273 putative hydrophobic ligand binding site [chemical binding]; other site 568707010274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707010275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707010276 putative substrate translocation pore; other site 568707010277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707010278 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 568707010279 EamA-like transporter family; Region: EamA; pfam00892 568707010280 EamA-like transporter family; Region: EamA; pfam00892 568707010281 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 568707010282 PLD-like domain; Region: PLDc_2; pfam13091 568707010283 putative active site [active] 568707010284 catalytic site [active] 568707010285 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 568707010286 PLD-like domain; Region: PLDc_2; pfam13091 568707010287 putative active site [active] 568707010288 catalytic site [active] 568707010289 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 568707010290 putative catalytic site [active] 568707010291 putative metal binding site [ion binding]; other site 568707010292 putative phosphate binding site [ion binding]; other site 568707010293 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 568707010294 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 568707010295 dimer interface [polypeptide binding]; other site 568707010296 anticodon binding site; other site 568707010297 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 568707010298 homodimer interface [polypeptide binding]; other site 568707010299 motif 1; other site 568707010300 active site 568707010301 motif 2; other site 568707010302 GAD domain; Region: GAD; pfam02938 568707010303 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 568707010304 motif 3; other site 568707010305 Uncharacterized conserved protein [Function unknown]; Region: COG2928 568707010306 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 568707010307 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 568707010308 choline dehydrogenase; Validated; Region: PRK02106 568707010309 lycopene cyclase; Region: lycopene_cycl; TIGR01789 568707010310 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 568707010312 Methyltransferase domain; Region: Methyltransf_31; pfam13847 568707010313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707010314 S-adenosylmethionine binding site [chemical binding]; other site 568707010315 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568707010316 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 568707010317 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 568707010318 dimer interface [polypeptide binding]; other site 568707010319 active site 568707010320 Fatty acid desaturase; Region: FA_desaturase; pfam00487 568707010321 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 568707010322 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 568707010323 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568707010324 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 568707010325 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 568707010326 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 568707010327 dimer interface [polypeptide binding]; other site 568707010328 active site 568707010329 catalytic residue [active] 568707010330 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 568707010331 GAF domain; Region: GAF_2; pfam13185 568707010332 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 568707010333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707010334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707010335 homodimer interface [polypeptide binding]; other site 568707010336 catalytic residue [active] 568707010337 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 568707010338 UbiA prenyltransferase family; Region: UbiA; pfam01040 568707010339 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 568707010340 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 568707010341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707010342 DNA-binding site [nucleotide binding]; DNA binding site 568707010343 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568707010344 malate synthase G; Provisional; Region: PRK02999 568707010345 active site 568707010346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707010347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707010348 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 568707010349 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568707010350 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 568707010351 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707010352 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707010353 Walker A/P-loop; other site 568707010354 ATP binding site [chemical binding]; other site 568707010355 Q-loop/lid; other site 568707010356 ABC transporter signature motif; other site 568707010357 Walker B; other site 568707010358 D-loop; other site 568707010359 H-loop/switch region; other site 568707010360 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707010361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707010362 dimer interface [polypeptide binding]; other site 568707010363 conserved gate region; other site 568707010364 putative PBP binding loops; other site 568707010365 ABC-ATPase subunit interface; other site 568707010366 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568707010367 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 568707010368 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707010369 membrane-bound complex binding site; other site 568707010370 hinge residues; other site 568707010371 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707010372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707010373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707010374 dimerization interface [polypeptide binding]; other site 568707010375 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; pfam10707 568707010376 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707010377 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568707010378 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707010379 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 568707010380 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568707010381 active site 568707010382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707010383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707010384 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 568707010385 substrate binding pocket [chemical binding]; other site 568707010386 dimerization interface [polypeptide binding]; other site 568707010387 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707010388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707010389 DNA-binding site [nucleotide binding]; DNA binding site 568707010390 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568707010391 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707010392 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 568707010393 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 568707010394 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 568707010395 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707010396 N-terminal plug; other site 568707010397 ligand-binding site [chemical binding]; other site 568707010398 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 568707010399 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568707010400 dimer interface [polypeptide binding]; other site 568707010401 ssDNA binding site [nucleotide binding]; other site 568707010402 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568707010403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707010404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707010405 putative substrate translocation pore; other site 568707010406 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 568707010407 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568707010408 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568707010409 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 568707010410 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 568707010411 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 568707010412 putative C-terminal domain interface [polypeptide binding]; other site 568707010413 putative GSH binding site (G-site) [chemical binding]; other site 568707010414 putative dimer interface [polypeptide binding]; other site 568707010415 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 568707010416 putative substrate binding pocket (H-site) [chemical binding]; other site 568707010417 putative N-terminal domain interface [polypeptide binding]; other site 568707010418 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 568707010419 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568707010420 Zn2+ binding site [ion binding]; other site 568707010421 Mg2+ binding site [ion binding]; other site 568707010422 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 568707010423 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 568707010424 active site 568707010425 dimer interface [polypeptide binding]; other site 568707010426 metal binding site [ion binding]; metal-binding site 568707010427 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 568707010428 shikimate kinase; Reviewed; Region: aroK; PRK00131 568707010429 ADP binding site [chemical binding]; other site 568707010430 magnesium binding site [ion binding]; other site 568707010431 putative shikimate binding site; other site 568707010432 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 568707010433 Transglycosylase; Region: Transgly; pfam00912 568707010434 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 568707010435 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 568707010436 putative iron binding site [ion binding]; other site 568707010437 diaminopimelate decarboxylase; Region: lysA; TIGR01048 568707010438 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 568707010439 active site 568707010440 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568707010441 substrate binding site [chemical binding]; other site 568707010442 catalytic residues [active] 568707010443 dimer interface [polypeptide binding]; other site 568707010444 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 568707010445 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 568707010446 ResB-like family; Region: ResB; pfam05140 568707010447 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 568707010448 ResB-like family; Region: ResB; pfam05140 568707010449 Cytochrome c; Region: Cytochrom_C; cl11414 568707010450 Cytochrome c; Region: Cytochrom_C; cl11414 568707010451 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 568707010452 G1 box; other site 568707010453 GTP/Mg2+ binding site [chemical binding]; other site 568707010454 Switch I region; other site 568707010455 G2 box; other site 568707010456 G3 box; other site 568707010457 Switch II region; other site 568707010458 G4 box; other site 568707010459 G5 box; other site 568707010460 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 568707010461 dimer interface [polypeptide binding]; other site 568707010462 active site 568707010463 aspartate-rich active site metal binding site; other site 568707010464 allosteric magnesium binding site [ion binding]; other site 568707010465 Schiff base residues; other site 568707010466 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568707010467 EamA-like transporter family; Region: EamA; pfam00892 568707010468 EamA-like transporter family; Region: EamA; pfam00892 568707010469 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 568707010470 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 568707010471 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 568707010472 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 568707010473 DsbD alpha interface [polypeptide binding]; other site 568707010474 catalytic residues [active] 568707010475 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 568707010476 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 568707010477 nucleotide binding site/active site [active] 568707010478 HIT family signature motif; other site 568707010479 catalytic residue [active] 568707010480 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 568707010481 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 568707010482 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 568707010483 alphaNTD homodimer interface [polypeptide binding]; other site 568707010484 alphaNTD - beta interaction site [polypeptide binding]; other site 568707010485 alphaNTD - beta' interaction site [polypeptide binding]; other site 568707010486 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 568707010487 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 568707010488 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 568707010489 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568707010490 RNA binding surface [nucleotide binding]; other site 568707010491 30S ribosomal protein S11; Validated; Region: PRK05309 568707010492 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 568707010493 30S ribosomal protein S13; Region: bact_S13; TIGR03631 568707010494 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 568707010495 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 568707010496 rRNA binding site [nucleotide binding]; other site 568707010497 predicted 30S ribosome binding site; other site 568707010498 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 568707010499 SecY translocase; Region: SecY; pfam00344 568707010500 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 568707010501 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 568707010502 23S rRNA binding site [nucleotide binding]; other site 568707010503 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 568707010504 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 568707010505 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 568707010506 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 568707010507 5S rRNA interface [nucleotide binding]; other site 568707010508 L27 interface [polypeptide binding]; other site 568707010509 23S rRNA interface [nucleotide binding]; other site 568707010510 L5 interface [polypeptide binding]; other site 568707010511 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 568707010512 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568707010513 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568707010514 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 568707010515 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 568707010516 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 568707010517 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 568707010518 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 568707010519 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 568707010520 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 568707010521 RNA binding site [nucleotide binding]; other site 568707010522 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 568707010523 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707010524 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 568707010525 tetramerization interface [polypeptide binding]; other site 568707010526 NAD(P) binding site [chemical binding]; other site 568707010527 catalytic residues [active] 568707010528 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568707010529 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 568707010530 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 568707010531 23S rRNA interface [nucleotide binding]; other site 568707010532 putative translocon interaction site; other site 568707010533 signal recognition particle (SRP54) interaction site; other site 568707010534 L23 interface [polypeptide binding]; other site 568707010535 trigger factor interaction site; other site 568707010536 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 568707010537 23S rRNA interface [nucleotide binding]; other site 568707010538 5S rRNA interface [nucleotide binding]; other site 568707010539 putative antibiotic binding site [chemical binding]; other site 568707010540 L25 interface [polypeptide binding]; other site 568707010541 L27 interface [polypeptide binding]; other site 568707010542 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 568707010543 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 568707010544 G-X-X-G motif; other site 568707010545 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 568707010546 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 568707010547 putative translocon binding site; other site 568707010548 protein-rRNA interface [nucleotide binding]; other site 568707010549 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 568707010550 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 568707010551 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 568707010552 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 568707010553 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 568707010554 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 568707010555 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 568707010556 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 568707010557 elongation factor Tu; Reviewed; Region: PRK00049 568707010558 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 568707010559 G1 box; other site 568707010560 GEF interaction site [polypeptide binding]; other site 568707010561 GTP/Mg2+ binding site [chemical binding]; other site 568707010562 Switch I region; other site 568707010563 G2 box; other site 568707010564 G3 box; other site 568707010565 Switch II region; other site 568707010566 G4 box; other site 568707010567 G5 box; other site 568707010568 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 568707010569 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 568707010570 Antibiotic Binding Site [chemical binding]; other site 568707010571 elongation factor G; Reviewed; Region: PRK00007 568707010572 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 568707010573 G1 box; other site 568707010574 putative GEF interaction site [polypeptide binding]; other site 568707010575 GTP/Mg2+ binding site [chemical binding]; other site 568707010576 Switch I region; other site 568707010577 G2 box; other site 568707010578 G3 box; other site 568707010579 Switch II region; other site 568707010580 G4 box; other site 568707010581 G5 box; other site 568707010582 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 568707010583 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 568707010584 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 568707010585 30S ribosomal protein S7; Validated; Region: PRK05302 568707010586 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 568707010587 S17 interaction site [polypeptide binding]; other site 568707010588 S8 interaction site; other site 568707010589 16S rRNA interaction site [nucleotide binding]; other site 568707010590 streptomycin interaction site [chemical binding]; other site 568707010591 23S rRNA interaction site [nucleotide binding]; other site 568707010592 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 568707010593 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 568707010594 putative metal binding site [ion binding]; other site 568707010595 putative homodimer interface [polypeptide binding]; other site 568707010596 putative homotetramer interface [polypeptide binding]; other site 568707010597 putative homodimer-homodimer interface [polypeptide binding]; other site 568707010598 putative allosteric switch controlling residues; other site 568707010599 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 568707010600 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568707010601 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568707010602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707010603 active site 568707010604 phosphorylation site [posttranslational modification] 568707010605 intermolecular recognition site; other site 568707010606 dimerization interface [polypeptide binding]; other site 568707010607 DNA binding site [nucleotide binding] 568707010608 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 568707010609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568707010610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707010611 active site 568707010612 phosphorylation site [posttranslational modification] 568707010613 intermolecular recognition site; other site 568707010614 dimerization interface [polypeptide binding]; other site 568707010615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707010616 DNA binding site [nucleotide binding] 568707010617 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568707010618 FecR protein; Region: FecR; pfam04773 568707010619 CHASE2 domain; Region: CHASE2; pfam05226 568707010620 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 568707010621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707010622 dimer interface [polypeptide binding]; other site 568707010623 phosphorylation site [posttranslational modification] 568707010624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707010625 ATP binding site [chemical binding]; other site 568707010626 Mg2+ binding site [ion binding]; other site 568707010627 G-X-G motif; other site 568707010628 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 568707010629 substrate binding site [chemical binding]; other site 568707010630 activation loop (A-loop); other site 568707010631 PEGA domain; Region: PEGA; pfam08308 568707010632 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 568707010633 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 568707010634 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 568707010635 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 568707010636 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 568707010637 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 568707010638 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 568707010639 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 568707010640 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 568707010641 DNA binding site [nucleotide binding] 568707010642 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 568707010643 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 568707010644 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 568707010645 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 568707010646 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 568707010647 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 568707010648 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 568707010649 RPB3 interaction site [polypeptide binding]; other site 568707010650 RPB1 interaction site [polypeptide binding]; other site 568707010651 RPB11 interaction site [polypeptide binding]; other site 568707010652 RPB10 interaction site [polypeptide binding]; other site 568707010653 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 568707010654 core dimer interface [polypeptide binding]; other site 568707010655 peripheral dimer interface [polypeptide binding]; other site 568707010656 L10 interface [polypeptide binding]; other site 568707010657 L11 interface [polypeptide binding]; other site 568707010658 putative EF-Tu interaction site [polypeptide binding]; other site 568707010659 putative EF-G interaction site [polypeptide binding]; other site 568707010660 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 568707010661 23S rRNA interface [nucleotide binding]; other site 568707010662 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 568707010663 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 568707010664 mRNA/rRNA interface [nucleotide binding]; other site 568707010665 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 568707010666 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 568707010667 23S rRNA interface [nucleotide binding]; other site 568707010668 L7/L12 interface [polypeptide binding]; other site 568707010669 putative thiostrepton binding site; other site 568707010670 L25 interface [polypeptide binding]; other site 568707010671 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 568707010672 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 568707010673 putative homodimer interface [polypeptide binding]; other site 568707010674 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 568707010675 heterodimer interface [polypeptide binding]; other site 568707010676 homodimer interface [polypeptide binding]; other site 568707010677 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 568707010678 elongation factor Tu; Reviewed; Region: PRK00049 568707010679 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 568707010680 G1 box; other site 568707010681 GEF interaction site [polypeptide binding]; other site 568707010682 GTP/Mg2+ binding site [chemical binding]; other site 568707010683 Switch I region; other site 568707010684 G2 box; other site 568707010685 G3 box; other site 568707010686 Switch II region; other site 568707010687 G4 box; other site 568707010688 G5 box; other site 568707010689 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 568707010690 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 568707010691 Antibiotic Binding Site [chemical binding]; other site 568707010692 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 568707010693 active site 568707010694 homotetramer interface [polypeptide binding]; other site 568707010695 homodimer interface [polypeptide binding]; other site 568707010696 ParB-like nuclease domain; Region: ParB; smart00470 568707010697 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 568707010698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707010699 Coenzyme A binding pocket [chemical binding]; other site 568707010700 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 568707010701 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 568707010702 P-loop; other site 568707010703 Magnesium ion binding site [ion binding]; other site 568707010704 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 568707010705 Magnesium ion binding site [ion binding]; other site 568707010706 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 568707010707 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 568707010708 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 568707010709 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 568707010710 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 568707010711 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 568707010712 DNA-binding site [nucleotide binding]; DNA binding site 568707010713 RNA-binding motif; other site 568707010714 methionine aminotransferase; Validated; Region: PRK09082 568707010715 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707010716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707010717 homodimer interface [polypeptide binding]; other site 568707010718 catalytic residue [active] 568707010719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 568707010720 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 568707010721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707010722 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 568707010723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568707010724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707010725 dimer interface [polypeptide binding]; other site 568707010726 phosphorylation site [posttranslational modification] 568707010727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707010728 ATP binding site [chemical binding]; other site 568707010729 Mg2+ binding site [ion binding]; other site 568707010730 G-X-G motif; other site 568707010731 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 568707010732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707010733 active site 568707010734 phosphorylation site [posttranslational modification] 568707010735 intermolecular recognition site; other site 568707010736 dimerization interface [polypeptide binding]; other site 568707010737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707010738 DNA binding site [nucleotide binding] 568707010739 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 568707010740 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 568707010741 trmE is a tRNA modification GTPase; Region: trmE; cd04164 568707010742 G1 box; other site 568707010743 GTP/Mg2+ binding site [chemical binding]; other site 568707010744 Switch I region; other site 568707010745 G2 box; other site 568707010746 Switch II region; other site 568707010747 G3 box; other site 568707010748 G4 box; other site 568707010749 G5 box; other site 568707010750 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 568707010751 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568707010752 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 568707010753 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707010754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707010755 dimer interface [polypeptide binding]; other site 568707010756 conserved gate region; other site 568707010757 putative PBP binding loops; other site 568707010758 ABC-ATPase subunit interface; other site 568707010759 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568707010760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707010761 dimer interface [polypeptide binding]; other site 568707010762 conserved gate region; other site 568707010763 putative PBP binding loops; other site 568707010764 ABC-ATPase subunit interface; other site 568707010765 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568707010766 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707010767 Walker A/P-loop; other site 568707010768 ATP binding site [chemical binding]; other site 568707010769 Q-loop/lid; other site 568707010770 ABC transporter signature motif; other site 568707010771 Walker B; other site 568707010772 D-loop; other site 568707010773 H-loop/switch region; other site 568707010774 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568707010775 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 568707010776 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707010777 Walker A/P-loop; other site 568707010778 ATP binding site [chemical binding]; other site 568707010779 Q-loop/lid; other site 568707010780 ABC transporter signature motif; other site 568707010781 Walker B; other site 568707010782 D-loop; other site 568707010783 H-loop/switch region; other site 568707010784 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568707010785 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 568707010786 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 568707010787 metal binding site [ion binding]; metal-binding site 568707010788 putative dimer interface [polypeptide binding]; other site 568707010789 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 568707010790 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 568707010791 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 568707010792 NMT1-like family; Region: NMT1_2; pfam13379 568707010793 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568707010794 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707010795 Walker A/P-loop; other site 568707010796 ATP binding site [chemical binding]; other site 568707010797 Q-loop/lid; other site 568707010798 ABC transporter signature motif; other site 568707010799 Walker B; other site 568707010800 D-loop; other site 568707010801 H-loop/switch region; other site 568707010802 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707010803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707010804 putative PBP binding loops; other site 568707010805 ABC-ATPase subunit interface; other site 568707010806 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 568707010807 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 568707010808 tetramer interface [polypeptide binding]; other site 568707010809 heme binding pocket [chemical binding]; other site 568707010810 NADPH binding site [chemical binding]; other site 568707010811 membrane protein insertase; Provisional; Region: PRK01318 568707010812 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 568707010813 Haemolytic domain; Region: Haemolytic; pfam01809 568707010814 ribonuclease P; Reviewed; Region: rnpA; PRK00038 568707010815 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 568707010816 DnaA N-terminal domain; Region: DnaA_N; pfam11638 568707010817 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 568707010818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707010819 Walker A motif; other site 568707010820 ATP binding site [chemical binding]; other site 568707010821 Walker B motif; other site 568707010822 arginine finger; other site 568707010823 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 568707010824 DnaA box-binding interface [nucleotide binding]; other site 568707010825 DNA polymerase III subunit beta; Validated; Region: PRK05643 568707010826 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 568707010827 putative DNA binding surface [nucleotide binding]; other site 568707010828 dimer interface [polypeptide binding]; other site 568707010829 beta-clamp/clamp loader binding surface; other site 568707010830 beta-clamp/translesion DNA polymerase binding surface; other site 568707010831 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 568707010832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707010833 ATP binding site [chemical binding]; other site 568707010834 Mg2+ binding site [ion binding]; other site 568707010835 G-X-G motif; other site 568707010836 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 568707010837 anchoring element; other site 568707010838 dimer interface [polypeptide binding]; other site 568707010839 ATP binding site [chemical binding]; other site 568707010840 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 568707010841 active site 568707010842 putative metal-binding site [ion binding]; other site 568707010843 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568707010844 FOG: WD40 repeat [General function prediction only]; Region: COG2319 568707010846 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 568707010847 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707010848 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707010849 amidase; Provisional; Region: PRK07486 568707010850 Amidase; Region: Amidase; pfam01425 568707010851 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707010852 acylphosphatase; Provisional; Region: PRK14424 568707010853 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 568707010854 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 568707010855 active site 568707010856 substrate binding site [chemical binding]; other site 568707010857 FMN binding site [chemical binding]; other site 568707010858 putative catalytic residues [active] 568707010859 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568707010860 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 568707010861 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_5; cd06232 568707010862 putative active site [active] 568707010863 Zn binding site [ion binding]; other site 568707010864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568707010865 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 568707010866 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568707010867 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 568707010868 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 568707010869 active site residue [active] 568707010870 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 568707010871 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 568707010872 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 568707010873 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 568707010874 NADH(P)-binding; Region: NAD_binding_10; pfam13460 568707010875 NAD binding site [chemical binding]; other site 568707010876 putative active site [active] 568707010877 substrate binding site [chemical binding]; other site 568707010878 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 568707010879 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 568707010880 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK00014 568707010881 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 568707010882 Proteins containing SET domain [General function prediction only]; Region: COG2940 568707010883 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 568707010884 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 568707010885 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568707010886 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707010887 putative DNA binding site [nucleotide binding]; other site 568707010888 putative Zn2+ binding site [ion binding]; other site 568707010889 AsnC family; Region: AsnC_trans_reg; pfam01037 568707010890 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 568707010891 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707010892 PYR/PP interface [polypeptide binding]; other site 568707010893 dimer interface [polypeptide binding]; other site 568707010894 TPP binding site [chemical binding]; other site 568707010895 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707010896 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 568707010897 TPP-binding site [chemical binding]; other site 568707010898 dimer interface [polypeptide binding]; other site 568707010899 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 568707010900 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 568707010901 putative NAD(P) binding site [chemical binding]; other site 568707010902 active site 568707010903 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707010904 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 568707010905 NAD(P) binding site [chemical binding]; other site 568707010906 catalytic residues [active] 568707010907 catalytic residues [active] 568707010908 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 568707010909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707010910 NAD(P) binding site [chemical binding]; other site 568707010911 active site 568707010912 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707010913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707010914 dimer interface [polypeptide binding]; other site 568707010915 conserved gate region; other site 568707010916 putative PBP binding loops; other site 568707010917 ABC-ATPase subunit interface; other site 568707010918 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707010919 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707010920 Walker A/P-loop; other site 568707010921 ATP binding site [chemical binding]; other site 568707010922 Q-loop/lid; other site 568707010923 ABC transporter signature motif; other site 568707010924 Walker B; other site 568707010925 D-loop; other site 568707010926 H-loop/switch region; other site 568707010927 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 568707010928 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568707010929 DNA topoisomerase III; Validated; Region: PRK08173 568707010930 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 568707010931 active site 568707010932 putative interdomain interaction site [polypeptide binding]; other site 568707010933 putative metal-binding site [ion binding]; other site 568707010934 putative nucleotide binding site [chemical binding]; other site 568707010935 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 568707010936 domain I; other site 568707010937 DNA binding groove [nucleotide binding] 568707010938 phosphate binding site [ion binding]; other site 568707010939 domain II; other site 568707010940 domain III; other site 568707010941 nucleotide binding site [chemical binding]; other site 568707010942 catalytic site [active] 568707010943 domain IV; other site 568707010944 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 568707010945 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 568707010946 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 568707010947 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 568707010948 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 568707010949 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 568707010950 active site 568707010951 HIGH motif; other site 568707010952 nucleotide binding site [chemical binding]; other site 568707010953 active site 568707010954 KMSKS motif; other site 568707010955 Protein of unknown function (DUF494); Region: DUF494; pfam04361 568707010956 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 568707010957 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707010958 N-terminal plug; other site 568707010959 ligand-binding site [chemical binding]; other site 568707010960 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 568707010961 DctM-like transporters; Region: DctM; pfam06808 568707010962 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 568707010963 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 568707010964 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 568707010965 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 568707010966 active site 568707010967 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568707010968 dimer interface [polypeptide binding]; other site 568707010969 substrate binding site [chemical binding]; other site 568707010970 catalytic residue [active] 568707010971 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707010972 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 568707010973 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568707010974 inhibitor-cofactor binding pocket; inhibition site 568707010975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707010976 catalytic residue [active] 568707010977 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 568707010978 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 568707010979 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568707010980 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568707010981 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568707010982 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568707010983 carboxyltransferase (CT) interaction site; other site 568707010984 biotinylation site [posttranslational modification]; other site 568707010985 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 568707010986 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 568707010987 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 568707010988 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568707010989 dimer interface [polypeptide binding]; other site 568707010990 active site 568707010991 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 568707010992 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315 568707010993 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 568707010994 isovaleryl-CoA dehydrogenase; Region: PLN02519 568707010995 substrate binding site [chemical binding]; other site 568707010996 FAD binding site [chemical binding]; other site 568707010997 catalytic base [active] 568707010998 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 568707010999 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 568707011000 DNA binding residues [nucleotide binding] 568707011001 putative dimer interface [polypeptide binding]; other site 568707011002 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 568707011003 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 568707011004 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 568707011005 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568707011006 homodimer interface [polypeptide binding]; other site 568707011007 substrate-cofactor binding pocket; other site 568707011008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707011009 catalytic residue [active] 568707011010 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 568707011011 catalytic residues [active] 568707011012 hinge region; other site 568707011013 alpha helical domain; other site 568707011014 Sporulation related domain; Region: SPOR; pfam05036 568707011015 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 568707011016 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 568707011017 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 568707011018 active site 568707011019 HIGH motif; other site 568707011020 KMSK motif region; other site 568707011021 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 568707011022 tRNA binding surface [nucleotide binding]; other site 568707011023 anticodon binding site; other site 568707011024 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 568707011025 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568707011026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707011027 dimer interface [polypeptide binding]; other site 568707011028 conserved gate region; other site 568707011029 putative PBP binding loops; other site 568707011030 ABC-ATPase subunit interface; other site 568707011031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707011032 dimer interface [polypeptide binding]; other site 568707011033 conserved gate region; other site 568707011034 putative PBP binding loops; other site 568707011035 ABC-ATPase subunit interface; other site 568707011036 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568707011037 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568707011038 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 568707011039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707011040 Walker A/P-loop; other site 568707011041 ATP binding site [chemical binding]; other site 568707011042 Q-loop/lid; other site 568707011043 ABC transporter signature motif; other site 568707011044 Walker B; other site 568707011045 D-loop; other site 568707011046 H-loop/switch region; other site 568707011047 TOBE domain; Region: TOBE_2; pfam08402 568707011048 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 568707011049 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568707011050 active site 568707011051 metal binding site [ion binding]; metal-binding site 568707011052 hexamer interface [polypeptide binding]; other site 568707011053 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568707011054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707011055 Walker A/P-loop; other site 568707011056 ATP binding site [chemical binding]; other site 568707011057 Q-loop/lid; other site 568707011058 ABC transporter signature motif; other site 568707011059 Walker B; other site 568707011060 D-loop; other site 568707011061 H-loop/switch region; other site 568707011062 TOBE domain; Region: TOBE_2; pfam08402 568707011063 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568707011064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707011065 dimer interface [polypeptide binding]; other site 568707011066 conserved gate region; other site 568707011067 putative PBP binding loops; other site 568707011068 ABC-ATPase subunit interface; other site 568707011069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707011070 dimer interface [polypeptide binding]; other site 568707011071 conserved gate region; other site 568707011072 putative PBP binding loops; other site 568707011073 ABC-ATPase subunit interface; other site 568707011074 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568707011075 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 568707011076 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568707011077 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568707011078 DNA binding site [nucleotide binding] 568707011079 domain linker motif; other site 568707011080 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 568707011081 putative dimerization interface [polypeptide binding]; other site 568707011082 putative ligand binding site [chemical binding]; other site 568707011083 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568707011084 Amidase; Region: Amidase; cl11426 568707011085 2-isopropylmalate synthase; Validated; Region: PRK03739 568707011086 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 568707011087 active site 568707011088 catalytic residues [active] 568707011089 metal binding site [ion binding]; metal-binding site 568707011090 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 568707011091 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 568707011092 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 568707011093 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 568707011094 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 568707011095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707011096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707011097 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707011098 dimerization interface [polypeptide binding]; other site 568707011099 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568707011100 EamA-like transporter family; Region: EamA; pfam00892 568707011101 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 568707011102 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 568707011103 heme binding site [chemical binding]; other site 568707011104 ferroxidase pore; other site 568707011105 ferroxidase diiron center [ion binding]; other site 568707011106 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 568707011107 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 568707011108 G1 box; other site 568707011109 putative GEF interaction site [polypeptide binding]; other site 568707011110 GTP/Mg2+ binding site [chemical binding]; other site 568707011111 Switch I region; other site 568707011112 G2 box; other site 568707011113 G3 box; other site 568707011114 Switch II region; other site 568707011115 G4 box; other site 568707011116 G5 box; other site 568707011117 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 568707011118 LysE type translocator; Region: LysE; cl00565 568707011119 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568707011120 DEAD-like helicases superfamily; Region: DEXDc; smart00487 568707011121 ATP binding site [chemical binding]; other site 568707011122 Mg++ binding site [ion binding]; other site 568707011123 motif III; other site 568707011124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568707011125 nucleotide binding region [chemical binding]; other site 568707011126 ATP-binding site [chemical binding]; other site 568707011127 LemA family; Region: LemA; pfam04011 568707011128 Repair protein; Region: Repair_PSII; pfam04536 568707011129 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 568707011130 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707011131 Walker A/P-loop; other site 568707011132 ATP binding site [chemical binding]; other site 568707011133 Q-loop/lid; other site 568707011134 ABC transporter signature motif; other site 568707011135 Walker B; other site 568707011136 D-loop; other site 568707011137 H-loop/switch region; other site 568707011138 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568707011139 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707011140 Walker A/P-loop; other site 568707011141 ATP binding site [chemical binding]; other site 568707011142 Q-loop/lid; other site 568707011143 ABC transporter signature motif; other site 568707011144 Walker B; other site 568707011145 D-loop; other site 568707011146 H-loop/switch region; other site 568707011147 dipeptide transporter; Provisional; Region: PRK10913 568707011148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707011149 dimer interface [polypeptide binding]; other site 568707011150 conserved gate region; other site 568707011151 putative PBP binding loops; other site 568707011152 ABC-ATPase subunit interface; other site 568707011153 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707011154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707011155 dimer interface [polypeptide binding]; other site 568707011156 conserved gate region; other site 568707011157 putative PBP binding loops; other site 568707011158 ABC-ATPase subunit interface; other site 568707011159 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 568707011160 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 568707011161 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 568707011162 G1 box; other site 568707011163 GTP/Mg2+ binding site [chemical binding]; other site 568707011164 G2 box; other site 568707011165 Switch I region; other site 568707011166 G3 box; other site 568707011167 Switch II region; other site 568707011168 G4 box; other site 568707011169 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 568707011170 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 568707011171 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 568707011172 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568707011173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707011174 EamA-like transporter family; Region: EamA; pfam00892 568707011175 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 568707011176 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 568707011177 Walker A motif; other site 568707011178 hexamer interface [polypeptide binding]; other site 568707011179 ATP binding site [chemical binding]; other site 568707011180 Walker B motif; other site 568707011181 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 568707011182 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 568707011183 VirB7 interaction site; other site 568707011184 VirB8 protein; Region: VirB8; pfam04335 568707011185 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 568707011186 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 568707011187 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 568707011188 Type IV secretory pathway, VirB3-like protein; Region: VirB3; pfam05101 568707011189 TrbC/VIRB2 family; Region: TrbC; pfam04956 568707011190 Aerolysin/Pertussis toxin (APT) domain; Region: APT; pfam03440 568707011191 Pertussis toxin, subunit 2 and 3, C-terminal domain; Region: Pertussis_S2S3; pfam02918 568707011192 Pertussis toxin S5 subunit; Region: Pertus-S5-tox; pfam09276 568707011193 Pertussis toxin S4 subunit; Region: Pertus-S4-tox; pfam09275 568707011194 Aerolysin/Pertussis toxin (APT) domain; Region: APT; pfam03440 568707011195 Pertussis toxin, subunit 2 and 3, C-terminal domain; Region: Pertussis_S2S3; pfam02918 568707011196 Pertussis toxin, subunit 1; Region: Pertussis_S1; pfam02917 568707011197 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011198 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 568707011199 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 568707011200 catalytic residues [active] 568707011201 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707011202 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707011203 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011204 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707011205 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707011206 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 568707011207 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568707011208 active site residue [active] 568707011209 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 568707011210 active site residue [active] 568707011211 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 568707011212 active site residue [active] 568707011213 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707011214 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707011215 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707011216 thioredoxin reductase; Provisional; Region: PRK10262 568707011217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568707011218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707011219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707011220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707011221 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 568707011222 putative dimerization interface [polypeptide binding]; other site 568707011223 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 568707011224 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 568707011225 active site 568707011226 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 568707011227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707011228 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 568707011229 Virulence protein [General function prediction only]; Region: COG3943 568707011230 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 568707011231 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 568707011233 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 568707011234 stringent starvation protein A; Provisional; Region: sspA; PRK09481 568707011235 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 568707011236 C-terminal domain interface [polypeptide binding]; other site 568707011237 putative GSH binding site (G-site) [chemical binding]; other site 568707011238 dimer interface [polypeptide binding]; other site 568707011239 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 568707011240 dimer interface [polypeptide binding]; other site 568707011241 N-terminal domain interface [polypeptide binding]; other site 568707011242 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 568707011243 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 568707011244 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 568707011245 Qi binding site; other site 568707011246 intrachain domain interface; other site 568707011247 interchain domain interface [polypeptide binding]; other site 568707011248 heme bH binding site [chemical binding]; other site 568707011249 heme bL binding site [chemical binding]; other site 568707011250 Qo binding site; other site 568707011251 interchain domain interface [polypeptide binding]; other site 568707011252 intrachain domain interface; other site 568707011253 Qi binding site; other site 568707011254 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 568707011255 Qo binding site; other site 568707011256 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 568707011257 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 568707011258 [2Fe-2S] cluster binding site [ion binding]; other site 568707011259 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 568707011260 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 568707011261 Uncharacterized conserved protein [Function unknown]; Region: COG0327 568707011262 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 568707011263 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 568707011264 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568707011265 protein binding site [polypeptide binding]; other site 568707011266 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568707011267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707011268 non-specific DNA binding site [nucleotide binding]; other site 568707011269 salt bridge; other site 568707011270 sequence-specific DNA binding site [nucleotide binding]; other site 568707011271 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 568707011272 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 568707011273 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 568707011274 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 568707011275 nucleotide binding site/active site [active] 568707011276 HIT family signature motif; other site 568707011277 catalytic residue [active] 568707011278 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 568707011279 metal binding site [ion binding]; metal-binding site 568707011280 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 568707011281 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 568707011282 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 568707011283 substrate binding site [chemical binding]; other site 568707011284 glutamase interaction surface [polypeptide binding]; other site 568707011285 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 568707011286 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 568707011287 catalytic residues [active] 568707011288 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 568707011289 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 568707011290 putative active site [active] 568707011291 oxyanion strand; other site 568707011292 catalytic triad [active] 568707011293 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 568707011294 putative active site pocket [active] 568707011295 4-fold oligomerization interface [polypeptide binding]; other site 568707011296 metal binding residues [ion binding]; metal-binding site 568707011297 3-fold/trimer interface [polypeptide binding]; other site 568707011298 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 568707011299 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707011300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707011301 homodimer interface [polypeptide binding]; other site 568707011302 catalytic residue [active] 568707011303 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 568707011304 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 568707011305 NAD binding site [chemical binding]; other site 568707011306 dimerization interface [polypeptide binding]; other site 568707011307 product binding site; other site 568707011308 substrate binding site [chemical binding]; other site 568707011309 zinc binding site [ion binding]; other site 568707011310 catalytic residues [active] 568707011311 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 568707011312 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 568707011313 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 568707011314 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 568707011315 hinge; other site 568707011316 active site 568707011317 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 568707011318 ABC-2 type transporter; Region: ABC2_membrane; cl17235 568707011319 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 568707011320 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 568707011321 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 568707011322 Walker A/P-loop; other site 568707011323 ATP binding site [chemical binding]; other site 568707011324 Q-loop/lid; other site 568707011325 ABC transporter signature motif; other site 568707011326 Walker B; other site 568707011327 D-loop; other site 568707011328 H-loop/switch region; other site 568707011329 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 568707011330 VacJ like lipoprotein; Region: VacJ; cl01073 568707011331 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 568707011332 mce related protein; Region: MCE; pfam02470 568707011333 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 568707011334 Permease; Region: Permease; pfam02405 568707011335 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 568707011336 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 568707011337 Walker A/P-loop; other site 568707011338 ATP binding site [chemical binding]; other site 568707011339 Q-loop/lid; other site 568707011340 ABC transporter signature motif; other site 568707011341 Walker B; other site 568707011342 D-loop; other site 568707011343 H-loop/switch region; other site 568707011344 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011345 OmpW family; Region: OmpW; cl17427 568707011346 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 568707011347 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568707011348 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 568707011349 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 568707011350 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 568707011351 active site 568707011352 dimer interface [polypeptide binding]; other site 568707011353 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 568707011354 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 568707011355 active site 568707011356 FMN binding site [chemical binding]; other site 568707011357 substrate binding site [chemical binding]; other site 568707011358 3Fe-4S cluster binding site [ion binding]; other site 568707011359 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 568707011360 domain interface; other site 568707011361 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 568707011362 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 568707011363 substrate binding site [chemical binding]; other site 568707011364 catalytic Zn binding site [ion binding]; other site 568707011365 NAD binding site [chemical binding]; other site 568707011366 structural Zn binding site [ion binding]; other site 568707011367 dimer interface [polypeptide binding]; other site 568707011368 S-formylglutathione hydrolase; Region: PLN02442 568707011369 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 568707011370 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 568707011371 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707011372 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568707011373 DNA binding residues [nucleotide binding] 568707011374 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 568707011375 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568707011376 active site 568707011377 metal binding site [ion binding]; metal-binding site 568707011378 hexamer interface [polypeptide binding]; other site 568707011379 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 568707011380 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568707011381 flexible hinge region; other site 568707011382 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 568707011383 nudix motif; other site 568707011384 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 568707011385 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 568707011386 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 568707011387 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 568707011388 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 568707011389 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 568707011390 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 568707011391 Subunit I/III interface [polypeptide binding]; other site 568707011392 D-pathway; other site 568707011393 Subunit I/VIIc interface [polypeptide binding]; other site 568707011394 Subunit I/IV interface [polypeptide binding]; other site 568707011395 Subunit I/II interface [polypeptide binding]; other site 568707011396 Low-spin heme (heme a) binding site [chemical binding]; other site 568707011397 Subunit I/VIIa interface [polypeptide binding]; other site 568707011398 Subunit I/VIa interface [polypeptide binding]; other site 568707011399 Dimer interface; other site 568707011400 Putative water exit pathway; other site 568707011401 Binuclear center (heme a3/CuB) [ion binding]; other site 568707011402 K-pathway; other site 568707011403 Subunit I/Vb interface [polypeptide binding]; other site 568707011404 Putative proton exit pathway; other site 568707011405 Subunit I/VIb interface; other site 568707011406 Subunit I/VIc interface [polypeptide binding]; other site 568707011407 Electron transfer pathway; other site 568707011408 Subunit I/VIIIb interface [polypeptide binding]; other site 568707011409 Subunit I/VIIb interface [polypeptide binding]; other site 568707011410 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 568707011411 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 568707011412 Subunit III/VIIa interface [polypeptide binding]; other site 568707011413 Phospholipid binding site [chemical binding]; other site 568707011414 Subunit I/III interface [polypeptide binding]; other site 568707011415 Subunit III/VIb interface [polypeptide binding]; other site 568707011416 Subunit III/VIa interface; other site 568707011417 Subunit III/Vb interface [polypeptide binding]; other site 568707011418 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 568707011419 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 568707011420 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 568707011421 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 568707011422 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 568707011423 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 568707011424 UbiA prenyltransferase family; Region: UbiA; pfam01040 568707011425 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 568707011426 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 568707011427 Cu(I) binding site [ion binding]; other site 568707011428 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 568707011429 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 568707011430 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 568707011431 Substrate binding site; other site 568707011432 Mg++ binding site; other site 568707011433 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 568707011434 active site 568707011435 substrate binding site [chemical binding]; other site 568707011436 CoA binding site [chemical binding]; other site 568707011437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707011438 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707011439 putative substrate translocation pore; other site 568707011440 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 568707011441 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 568707011442 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 568707011443 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568707011444 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568707011445 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568707011446 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568707011447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707011448 putative DNA binding site [nucleotide binding]; other site 568707011449 putative Zn2+ binding site [ion binding]; other site 568707011450 AsnC family; Region: AsnC_trans_reg; pfam01037 568707011451 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 568707011452 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 568707011453 glutaminase active site [active] 568707011454 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568707011455 dimer interface [polypeptide binding]; other site 568707011456 active site 568707011457 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 568707011458 dimer interface [polypeptide binding]; other site 568707011459 active site 568707011460 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568707011461 extended (e) SDRs; Region: SDR_e; cd08946 568707011462 NAD(P) binding site [chemical binding]; other site 568707011463 active site 568707011464 substrate binding site [chemical binding]; other site 568707011465 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011466 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 568707011467 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568707011468 enoyl-CoA hydratase; Provisional; Region: PRK07658 568707011469 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707011470 substrate binding site [chemical binding]; other site 568707011471 oxyanion hole (OAH) forming residues; other site 568707011472 trimer interface [polypeptide binding]; other site 568707011473 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 568707011474 CoA binding domain; Region: CoA_binding_2; pfam13380 568707011475 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 568707011476 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 568707011477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707011478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707011479 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 568707011480 putative substrate binding pocket [chemical binding]; other site 568707011481 dimerization interface [polypeptide binding]; other site 568707011482 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 568707011483 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 568707011484 NADP binding site [chemical binding]; other site 568707011485 dimer interface [polypeptide binding]; other site 568707011486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568707011487 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 568707011489 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 568707011490 acetylornithine deacetylase; Provisional; Region: PRK07522 568707011491 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 568707011492 metal binding site [ion binding]; metal-binding site 568707011493 putative dimer interface [polypeptide binding]; other site 568707011494 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011495 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 568707011496 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 568707011497 FAD binding site [chemical binding]; other site 568707011498 substrate binding site [chemical binding]; other site 568707011499 catalytic base [active] 568707011500 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 568707011501 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 568707011502 active site 568707011503 D-lactate dehydrogenase; Provisional; Region: PRK11183 568707011504 FAD binding domain; Region: FAD_binding_4; pfam01565 568707011505 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 568707011506 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 568707011507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707011508 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707011509 dimerization interface [polypeptide binding]; other site 568707011510 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011511 Protein of unknown function (DUF521); Region: DUF521; pfam04412 568707011512 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 568707011513 substrate binding site [chemical binding]; other site 568707011514 ligand binding site [chemical binding]; other site 568707011515 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 568707011516 substrate binding site [chemical binding]; other site 568707011517 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568707011518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707011519 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 568707011520 dimerization interface [polypeptide binding]; other site 568707011521 substrate binding pocket [chemical binding]; other site 568707011522 putative L-aspartate dehydrogenase; Provisional; Region: PRK13302 568707011523 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 568707011524 Domain of unknown function DUF108; Region: DUF108; pfam01958 568707011525 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568707011526 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 568707011527 putative NAD(P) binding site [chemical binding]; other site 568707011528 putative active site [active] 568707011530 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 568707011531 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568707011532 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 568707011533 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 568707011534 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568707011535 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 568707011536 Walker A/P-loop; other site 568707011537 ATP binding site [chemical binding]; other site 568707011538 Q-loop/lid; other site 568707011539 ABC transporter signature motif; other site 568707011540 Walker B; other site 568707011541 D-loop; other site 568707011542 H-loop/switch region; other site 568707011543 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 568707011544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707011545 dimer interface [polypeptide binding]; other site 568707011546 conserved gate region; other site 568707011547 putative PBP binding loops; other site 568707011548 ABC-ATPase subunit interface; other site 568707011549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707011550 dimer interface [polypeptide binding]; other site 568707011551 conserved gate region; other site 568707011552 putative PBP binding loops; other site 568707011553 ABC-ATPase subunit interface; other site 568707011554 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 568707011555 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 568707011556 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 568707011557 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 568707011558 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 568707011559 hydrophobic ligand binding site; other site 568707011560 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 568707011561 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 568707011562 FMN-binding pocket [chemical binding]; other site 568707011563 flavin binding motif; other site 568707011564 phosphate binding motif [ion binding]; other site 568707011565 beta-alpha-beta structure motif; other site 568707011566 NAD binding pocket [chemical binding]; other site 568707011567 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707011568 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568707011569 catalytic loop [active] 568707011570 iron binding site [ion binding]; other site 568707011571 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 568707011572 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568707011573 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 568707011574 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568707011575 putative active site [active] 568707011576 putative metal binding site [ion binding]; other site 568707011577 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 568707011578 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568707011579 active site 568707011580 metal binding site [ion binding]; metal-binding site 568707011581 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707011582 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707011583 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707011584 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707011585 enoyl-CoA hydratase; Region: PLN02864 568707011586 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707011587 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 568707011588 dimer interaction site [polypeptide binding]; other site 568707011589 substrate-binding tunnel; other site 568707011590 active site 568707011591 catalytic site [active] 568707011592 substrate binding site [chemical binding]; other site 568707011593 lipid-transfer protein; Provisional; Region: PRK08256 568707011594 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 568707011595 active site 568707011596 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707011597 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707011598 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 568707011599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707011600 NAD(P) binding site [chemical binding]; other site 568707011601 active site 568707011602 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 568707011603 active site 568707011604 catalytic site [active] 568707011605 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011606 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 568707011607 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 568707011608 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707011609 N-terminal plug; other site 568707011610 ligand-binding site [chemical binding]; other site 568707011611 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 568707011612 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 568707011613 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 568707011614 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 568707011615 Ligand binding site [chemical binding]; other site 568707011616 Electron transfer flavoprotein domain; Region: ETF; pfam01012 568707011617 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568707011618 MarR family; Region: MarR_2; cl17246 568707011619 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707011620 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707011621 substrate binding site [chemical binding]; other site 568707011622 oxyanion hole (OAH) forming residues; other site 568707011623 trimer interface [polypeptide binding]; other site 568707011624 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568707011625 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 568707011626 active site 568707011627 FMN binding site [chemical binding]; other site 568707011628 2,4-decadienoyl-CoA binding site; other site 568707011629 catalytic residue [active] 568707011630 4Fe-4S cluster binding site [ion binding]; other site 568707011631 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 568707011632 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568707011633 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707011634 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 568707011635 substrate binding site [chemical binding]; other site 568707011636 oxyanion hole (OAH) forming residues; other site 568707011637 trimer interface [polypeptide binding]; other site 568707011638 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011639 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707011640 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707011641 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707011642 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707011643 active site 568707011644 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707011645 active site 2 [active] 568707011646 active site 1 [active] 568707011647 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 568707011648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707011649 NAD(P) binding site [chemical binding]; other site 568707011650 active site 568707011651 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011652 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 568707011653 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 568707011654 NADP binding site [chemical binding]; other site 568707011655 dimer interface [polypeptide binding]; other site 568707011656 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707011657 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707011658 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707011659 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707011660 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707011661 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568707011662 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 568707011663 CoenzymeA binding site [chemical binding]; other site 568707011664 subunit interaction site [polypeptide binding]; other site 568707011665 PHB binding site; other site 568707011666 Secretin and TonB N terminus short domain; Region: STN; smart00965 568707011667 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 568707011668 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707011669 N-terminal plug; other site 568707011670 ligand-binding site [chemical binding]; other site 568707011671 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 568707011672 FecR protein; Region: FecR; pfam04773 568707011673 RNA polymerase factor sigma-70; Validated; Region: PRK09047 568707011674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568707011675 DNA binding residues [nucleotide binding] 568707011676 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 568707011677 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 568707011678 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 568707011679 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 568707011680 active site residue [active] 568707011681 selenophosphate synthetase; Provisional; Region: PRK00943 568707011682 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 568707011683 dimerization interface [polypeptide binding]; other site 568707011684 putative ATP binding site [chemical binding]; other site 568707011685 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568707011686 homotrimer interaction site [polypeptide binding]; other site 568707011687 putative active site [active] 568707011688 aspartate aminotransferase; Provisional; Region: PRK06207 568707011689 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707011690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707011691 homodimer interface [polypeptide binding]; other site 568707011692 catalytic residue [active] 568707011693 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 568707011694 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568707011695 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568707011696 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568707011697 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 568707011698 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568707011699 carboxyltransferase (CT) interaction site; other site 568707011700 biotinylation site [posttranslational modification]; other site 568707011701 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 568707011702 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568707011703 carboxyltransferase (CT) interaction site; other site 568707011704 N-formylglutamate amidohydrolase; Region: FGase; cl01522 568707011705 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 568707011706 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 568707011707 ligand binding site [chemical binding]; other site 568707011708 NAD binding site [chemical binding]; other site 568707011709 dimerization interface [polypeptide binding]; other site 568707011710 catalytic site [active] 568707011711 allantoate amidohydrolase; Reviewed; Region: PRK12891 568707011712 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 568707011713 active site 568707011714 metal binding site [ion binding]; metal-binding site 568707011715 dimer interface [polypeptide binding]; other site 568707011716 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 568707011717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707011718 Walker A/P-loop; other site 568707011719 ATP binding site [chemical binding]; other site 568707011720 Q-loop/lid; other site 568707011721 ABC transporter signature motif; other site 568707011722 Walker B; other site 568707011723 D-loop; other site 568707011724 H-loop/switch region; other site 568707011725 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568707011726 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707011727 Walker A/P-loop; other site 568707011728 ATP binding site [chemical binding]; other site 568707011729 Q-loop/lid; other site 568707011730 ABC transporter signature motif; other site 568707011731 Walker B; other site 568707011732 D-loop; other site 568707011733 H-loop/switch region; other site 568707011734 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707011735 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568707011736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707011737 dimer interface [polypeptide binding]; other site 568707011738 conserved gate region; other site 568707011739 putative PBP binding loops; other site 568707011740 ABC-ATPase subunit interface; other site 568707011741 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707011742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707011743 dimer interface [polypeptide binding]; other site 568707011744 conserved gate region; other site 568707011745 putative PBP binding loops; other site 568707011746 ABC-ATPase subunit interface; other site 568707011747 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568707011748 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 568707011749 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 568707011750 putative active site [active] 568707011751 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 568707011752 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 568707011753 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 568707011754 aspartate aminotransferase; Provisional; Region: PRK05764 568707011755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707011756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707011757 homodimer interface [polypeptide binding]; other site 568707011758 catalytic residue [active] 568707011759 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568707011760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707011761 DNA-binding site [nucleotide binding]; DNA binding site 568707011762 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568707011763 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 568707011764 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 568707011765 inhibitor site; inhibition site 568707011766 active site 568707011767 dimer interface [polypeptide binding]; other site 568707011768 catalytic residue [active] 568707011769 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 568707011770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707011771 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 568707011772 putative dimerization interface [polypeptide binding]; other site 568707011773 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707011774 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707011775 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011776 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707011777 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707011778 active site 568707011779 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707011780 active site 2 [active] 568707011781 active site 1 [active] 568707011782 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 568707011783 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 568707011784 DUF35 OB-fold domain; Region: DUF35; pfam01796 568707011785 thiolase; Provisional; Region: PRK06158 568707011786 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 568707011787 active site 568707011788 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707011789 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707011790 substrate binding site [chemical binding]; other site 568707011791 oxyanion hole (OAH) forming residues; other site 568707011792 trimer interface [polypeptide binding]; other site 568707011793 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707011794 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707011795 active site 568707011796 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011797 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 568707011798 CoA binding domain; Region: CoA_binding_2; pfam13380 568707011799 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 568707011800 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 568707011801 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707011802 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707011803 substrate binding site [chemical binding]; other site 568707011804 oxyanion hole (OAH) forming residues; other site 568707011805 trimer interface [polypeptide binding]; other site 568707011806 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707011807 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707011808 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707011809 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 568707011810 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 568707011811 tetramer interface [polypeptide binding]; other site 568707011812 TPP-binding site [chemical binding]; other site 568707011813 heterodimer interface [polypeptide binding]; other site 568707011814 phosphorylation loop region [posttranslational modification] 568707011815 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 568707011816 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 568707011817 alpha subunit interface [polypeptide binding]; other site 568707011818 TPP binding site [chemical binding]; other site 568707011819 heterodimer interface [polypeptide binding]; other site 568707011820 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568707011821 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707011822 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707011823 substrate binding site [chemical binding]; other site 568707011824 oxyanion hole (OAH) forming residues; other site 568707011825 trimer interface [polypeptide binding]; other site 568707011826 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 568707011827 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568707011828 E3 interaction surface; other site 568707011829 lipoyl attachment site [posttranslational modification]; other site 568707011830 e3 binding domain; Region: E3_binding; pfam02817 568707011831 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 568707011832 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707011833 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707011834 active site 568707011835 acyl-CoA synthetase; Validated; Region: PRK06145 568707011836 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707011837 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 568707011838 acyl-activating enzyme (AAE) consensus motif; other site 568707011839 acyl-activating enzyme (AAE) consensus motif; other site 568707011840 putative AMP binding site [chemical binding]; other site 568707011841 putative active site [active] 568707011842 putative CoA binding site [chemical binding]; other site 568707011843 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 568707011844 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707011845 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568707011846 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707011847 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707011848 TM-ABC transporter signature motif; other site 568707011849 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707011850 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707011851 TM-ABC transporter signature motif; other site 568707011852 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707011853 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707011854 Walker A/P-loop; other site 568707011855 ATP binding site [chemical binding]; other site 568707011856 Q-loop/lid; other site 568707011857 ABC transporter signature motif; other site 568707011858 Walker B; other site 568707011859 D-loop; other site 568707011860 H-loop/switch region; other site 568707011861 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707011862 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707011863 Walker A/P-loop; other site 568707011864 ATP binding site [chemical binding]; other site 568707011865 Q-loop/lid; other site 568707011866 ABC transporter signature motif; other site 568707011867 Walker B; other site 568707011868 D-loop; other site 568707011869 H-loop/switch region; other site 568707011870 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 568707011871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568707011872 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707011873 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568707011874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707011875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707011876 Amidohydrolase; Region: Amidohydro_2; pfam04909 568707011877 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011878 putative succinate dehydrogenase; Reviewed; Region: PRK12842 568707011879 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568707011880 Predicted oxidoreductase [General function prediction only]; Region: COG3573 568707011881 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707011882 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707011883 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707011884 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011885 Cupin domain; Region: Cupin_2; pfam07883 568707011886 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 568707011887 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 568707011888 active site pocket [active] 568707011889 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 568707011890 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 568707011891 putative NAD(P) binding site [chemical binding]; other site 568707011892 putative active site [active] 568707011893 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 568707011894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707011895 DNA-binding site [nucleotide binding]; DNA binding site 568707011896 FCD domain; Region: FCD; pfam07729 568707011897 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 568707011898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707011899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707011900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707011901 dimerization interface [polypeptide binding]; other site 568707011902 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011903 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 568707011904 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011905 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568707011906 CoenzymeA binding site [chemical binding]; other site 568707011907 subunit interaction site [polypeptide binding]; other site 568707011908 PHB binding site; other site 568707011909 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707011910 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707011911 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 568707011912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707011913 motif II; other site 568707011914 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 568707011915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707011916 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 568707011917 substrate binding pocket [chemical binding]; other site 568707011918 dimerization interface [polypeptide binding]; other site 568707011920 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 568707011921 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 568707011922 Subunit I/III interface [polypeptide binding]; other site 568707011923 D-pathway; other site 568707011924 Subunit I/VIIc interface [polypeptide binding]; other site 568707011925 Subunit I/IV interface [polypeptide binding]; other site 568707011926 Subunit I/II interface [polypeptide binding]; other site 568707011927 Low-spin heme (heme a) binding site [chemical binding]; other site 568707011928 Subunit I/VIIa interface [polypeptide binding]; other site 568707011929 Subunit I/VIa interface [polypeptide binding]; other site 568707011930 Dimer interface; other site 568707011931 Putative water exit pathway; other site 568707011932 Binuclear center (heme a3/CuB) [ion binding]; other site 568707011933 K-pathway; other site 568707011934 Subunit I/Vb interface [polypeptide binding]; other site 568707011935 Putative proton exit pathway; other site 568707011936 Subunit I/VIb interface; other site 568707011937 Subunit I/VIc interface [polypeptide binding]; other site 568707011938 Electron transfer pathway; other site 568707011939 Subunit I/VIIIb interface [polypeptide binding]; other site 568707011940 Subunit I/VIIb interface [polypeptide binding]; other site 568707011941 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 568707011942 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707011943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707011944 DNA-binding site [nucleotide binding]; DNA binding site 568707011945 FCD domain; Region: FCD; pfam07729 568707011946 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 568707011947 homodimer interface [polypeptide binding]; other site 568707011948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707011949 catalytic residue [active] 568707011950 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 568707011951 Beta-lactamase; Region: Beta-lactamase; pfam00144 568707011952 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 568707011953 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707011954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707011955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707011956 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707011957 dimerization interface [polypeptide binding]; other site 568707011958 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 568707011959 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 568707011960 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707011961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707011962 metal binding site [ion binding]; metal-binding site 568707011963 active site 568707011964 I-site; other site 568707011965 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 568707011966 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 568707011967 DNA binding site [nucleotide binding] 568707011968 active site 568707011969 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 568707011970 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 568707011971 Uncharacterized conserved protein [Function unknown]; Region: COG1683 568707011972 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 568707011973 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 568707011974 Walker A/P-loop; other site 568707011975 ATP binding site [chemical binding]; other site 568707011976 Q-loop/lid; other site 568707011977 ABC transporter signature motif; other site 568707011978 Walker B; other site 568707011979 D-loop; other site 568707011980 H-loop/switch region; other site 568707011981 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 568707011982 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568707011983 ABC-ATPase subunit interface; other site 568707011984 dimer interface [polypeptide binding]; other site 568707011985 putative PBP binding regions; other site 568707011986 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 568707011987 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 568707011988 intersubunit interface [polypeptide binding]; other site 568707011989 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 568707011990 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 568707011991 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 568707011992 Secretin and TonB N terminus short domain; Region: STN; smart00965 568707011993 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 568707011994 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707011995 N-terminal plug; other site 568707011996 ligand-binding site [chemical binding]; other site 568707011997 fec operon regulator FecR; Reviewed; Region: PRK09774 568707011998 FecR protein; Region: FecR; pfam04773 568707011999 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 568707012000 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707012001 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 568707012002 DNA binding residues [nucleotide binding] 568707012003 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568707012004 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707012005 catalytic loop [active] 568707012006 iron binding site [ion binding]; other site 568707012007 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568707012008 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707012009 catalytic loop [active] 568707012010 iron binding site [ion binding]; other site 568707012011 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 568707012012 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 568707012013 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707012014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707012015 DNA-binding site [nucleotide binding]; DNA binding site 568707012016 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 568707012017 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568707012018 SepZ; Region: SepZ; pfam06066 568707012019 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 568707012020 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 568707012021 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707012022 NAD(P) binding site [chemical binding]; other site 568707012023 catalytic residues [active] 568707012024 Domain of unknown function (DUF336); Region: DUF336; pfam03928 568707012025 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 568707012026 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707012027 catalytic loop [active] 568707012028 iron binding site [ion binding]; other site 568707012029 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 568707012030 FAD binding pocket [chemical binding]; other site 568707012031 FAD binding motif [chemical binding]; other site 568707012032 phosphate binding motif [ion binding]; other site 568707012033 beta-alpha-beta structure motif; other site 568707012034 NAD binding pocket [chemical binding]; other site 568707012035 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568707012036 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707012037 substrate binding pocket [chemical binding]; other site 568707012038 membrane-bound complex binding site; other site 568707012039 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 568707012040 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 568707012041 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 568707012042 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 568707012043 NodB motif; other site 568707012044 active site 568707012045 catalytic site [active] 568707012046 metal binding site [ion binding]; metal-binding site 568707012047 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 568707012048 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 568707012049 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 568707012050 Uncharacterized conserved protein [Function unknown]; Region: COG5361 568707012051 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 568707012052 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 568707012053 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 568707012054 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 568707012055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707012056 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707012057 dimerization interface [polypeptide binding]; other site 568707012058 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 568707012059 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 568707012060 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 568707012061 putative catalytic residue [active] 568707012062 short chain dehydrogenase; Provisional; Region: PRK06123 568707012063 classical (c) SDRs; Region: SDR_c; cd05233 568707012064 NAD(P) binding site [chemical binding]; other site 568707012065 active site 568707012066 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 568707012067 active site 568707012068 ribulose/triose binding site [chemical binding]; other site 568707012069 phosphate binding site [ion binding]; other site 568707012070 substrate (anthranilate) binding pocket [chemical binding]; other site 568707012071 product (indole) binding pocket [chemical binding]; other site 568707012072 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 568707012073 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 568707012074 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 568707012075 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 568707012076 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 568707012077 glutamine binding [chemical binding]; other site 568707012078 catalytic triad [active] 568707012079 anthranilate synthase component I; Provisional; Region: PRK13565 568707012080 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 568707012081 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 568707012082 phosphoglycolate phosphatase; Provisional; Region: PRK13222 568707012083 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707012084 motif II; other site 568707012085 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 568707012086 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 568707012087 substrate binding site [chemical binding]; other site 568707012088 hexamer interface [polypeptide binding]; other site 568707012089 metal binding site [ion binding]; metal-binding site 568707012090 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 568707012091 MltA specific insert domain; Region: MltA; smart00925 568707012092 3D domain; Region: 3D; pfam06725 568707012093 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 568707012094 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 568707012095 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 568707012096 dimerization domain [polypeptide binding]; other site 568707012097 dimer interface [polypeptide binding]; other site 568707012098 catalytic residues [active] 568707012099 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 568707012100 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 568707012101 dimerization interface [polypeptide binding]; other site 568707012102 NAD binding site [chemical binding]; other site 568707012103 ligand binding site [chemical binding]; other site 568707012104 catalytic site [active] 568707012105 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 568707012106 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 568707012107 Ligand Binding Site [chemical binding]; other site 568707012108 Dihydroneopterin aldolase; Region: FolB; pfam02152 568707012109 active site 568707012110 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 568707012111 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568707012112 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 568707012113 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 568707012114 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568707012115 enoyl-CoA hydratase; Provisional; Region: PRK05862 568707012116 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707012117 substrate binding site [chemical binding]; other site 568707012118 oxyanion hole (OAH) forming residues; other site 568707012119 trimer interface [polypeptide binding]; other site 568707012120 Uncharacterized conserved protein [Function unknown]; Region: COG5361 568707012121 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 568707012122 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 568707012123 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 568707012124 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 568707012125 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 568707012126 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 568707012127 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 568707012128 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 568707012129 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 568707012130 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 568707012131 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568707012132 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 568707012133 beta subunit interaction interface [polypeptide binding]; other site 568707012134 Walker A motif; other site 568707012135 ATP binding site [chemical binding]; other site 568707012136 Walker B motif; other site 568707012137 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568707012138 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 568707012139 core domain interface [polypeptide binding]; other site 568707012140 delta subunit interface [polypeptide binding]; other site 568707012141 epsilon subunit interface [polypeptide binding]; other site 568707012142 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 568707012143 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 568707012144 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 568707012145 alpha subunit interaction interface [polypeptide binding]; other site 568707012146 Walker A motif; other site 568707012147 ATP binding site [chemical binding]; other site 568707012148 Walker B motif; other site 568707012149 inhibitor binding site; inhibition site 568707012150 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568707012151 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 568707012152 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 568707012153 gamma subunit interface [polypeptide binding]; other site 568707012154 epsilon subunit interface [polypeptide binding]; other site 568707012155 LBP interface [polypeptide binding]; other site 568707012156 response regulator GlrR; Provisional; Region: PRK15115 568707012157 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 568707012158 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 568707012159 substrate binding site [chemical binding]; other site 568707012160 active site 568707012161 primosome assembly protein PriA; Validated; Region: PRK05580 568707012162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568707012163 ATP binding site [chemical binding]; other site 568707012164 putative Mg++ binding site [ion binding]; other site 568707012165 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 568707012166 Part of AAA domain; Region: AAA_19; pfam13245 568707012167 Family description; Region: UvrD_C_2; pfam13538 568707012168 hypothetical protein; Provisional; Region: PRK07338 568707012169 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 568707012170 metal binding site [ion binding]; metal-binding site 568707012171 dimer interface [polypeptide binding]; other site 568707012172 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 568707012173 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 568707012174 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707012175 Walker A/P-loop; other site 568707012176 ATP binding site [chemical binding]; other site 568707012177 Q-loop/lid; other site 568707012178 ABC transporter signature motif; other site 568707012179 Walker B; other site 568707012180 D-loop; other site 568707012181 H-loop/switch region; other site 568707012182 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568707012183 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568707012184 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707012185 Walker A/P-loop; other site 568707012186 ATP binding site [chemical binding]; other site 568707012187 Q-loop/lid; other site 568707012188 ABC transporter signature motif; other site 568707012189 Walker B; other site 568707012190 D-loop; other site 568707012191 H-loop/switch region; other site 568707012192 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568707012193 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568707012194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707012195 dimer interface [polypeptide binding]; other site 568707012196 conserved gate region; other site 568707012197 putative PBP binding loops; other site 568707012198 ABC-ATPase subunit interface; other site 568707012199 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707012200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707012201 dimer interface [polypeptide binding]; other site 568707012202 conserved gate region; other site 568707012203 putative PBP binding loops; other site 568707012204 ABC-ATPase subunit interface; other site 568707012205 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 568707012206 putative active site [active] 568707012207 Zn binding site [ion binding]; other site 568707012208 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 568707012209 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 568707012210 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 568707012211 putative ATP binding site [chemical binding]; other site 568707012212 putative substrate binding site [chemical binding]; other site 568707012213 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707012214 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707012215 substrate binding site [chemical binding]; other site 568707012216 oxyanion hole (OAH) forming residues; other site 568707012217 trimer interface [polypeptide binding]; other site 568707012218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 568707012219 enoyl-CoA hydratase; Provisional; Region: PRK06688 568707012220 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707012221 substrate binding site [chemical binding]; other site 568707012222 oxyanion hole (OAH) forming residues; other site 568707012223 trimer interface [polypeptide binding]; other site 568707012224 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 568707012225 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 568707012226 FMN binding site [chemical binding]; other site 568707012227 substrate binding site [chemical binding]; other site 568707012228 putative catalytic residue [active] 568707012229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707012230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707012231 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707012232 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707012233 active site 568707012234 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707012235 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707012236 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 568707012237 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 568707012238 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568707012239 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 568707012240 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 568707012241 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 568707012242 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 568707012243 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 568707012244 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 568707012245 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 568707012246 Multicopper oxidase; Region: Cu-oxidase; pfam00394 568707012247 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 568707012248 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 568707012249 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707012250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707012251 substrate binding site [chemical binding]; other site 568707012252 oxyanion hole (OAH) forming residues; other site 568707012253 trimer interface [polypeptide binding]; other site 568707012254 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707012255 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707012256 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707012257 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707012258 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707012259 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 568707012260 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568707012261 Amidase; Region: Amidase; pfam01425 568707012262 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568707012263 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568707012264 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707012265 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707012266 Walker A/P-loop; other site 568707012267 ATP binding site [chemical binding]; other site 568707012268 Q-loop/lid; other site 568707012269 ABC transporter signature motif; other site 568707012270 Walker B; other site 568707012271 D-loop; other site 568707012272 H-loop/switch region; other site 568707012273 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707012274 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707012275 Walker A/P-loop; other site 568707012276 ATP binding site [chemical binding]; other site 568707012277 Q-loop/lid; other site 568707012278 ABC transporter signature motif; other site 568707012279 Walker B; other site 568707012280 D-loop; other site 568707012281 H-loop/switch region; other site 568707012282 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707012283 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707012284 TM-ABC transporter signature motif; other site 568707012285 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707012286 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707012287 TM-ABC transporter signature motif; other site 568707012288 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568707012289 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568707012290 DNA binding site [nucleotide binding] 568707012291 domain linker motif; other site 568707012292 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 568707012293 putative dimerization interface [polypeptide binding]; other site 568707012294 putative ligand binding site [chemical binding]; other site 568707012295 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568707012296 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 568707012297 trimer interface [polypeptide binding]; other site 568707012298 eyelet of channel; other site 568707012299 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 568707012300 active site 568707012301 oligomerization interface [polypeptide binding]; other site 568707012302 metal binding site [ion binding]; metal-binding site 568707012303 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707012304 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707012305 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707012306 dimerization interface [polypeptide binding]; other site 568707012307 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707012308 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 568707012309 active site 568707012310 Zn binding site [ion binding]; other site 568707012311 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 568707012312 glutamate--cysteine ligase; Provisional; Region: PRK02107 568707012313 monoglyceride lipase; Provisional; Region: PHA02857 568707012314 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 568707012315 Serine hydrolase; Region: Ser_hydrolase; cl17834 568707012316 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707012317 DNA binding residues [nucleotide binding] 568707012318 Membrane transport protein; Region: Mem_trans; cl09117 568707012319 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 568707012320 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 568707012321 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 568707012322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 568707012323 muropeptide transporter; Reviewed; Region: ampG; PRK11902 568707012324 muropeptide transporter; Validated; Region: ampG; cl17669 568707012325 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568707012326 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 568707012327 trimer interface [polypeptide binding]; other site 568707012328 eyelet of channel; other site 568707012329 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 568707012330 aspartate racemase; Region: asp_race; TIGR00035 568707012331 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568707012332 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568707012333 Walker A/P-loop; other site 568707012334 ATP binding site [chemical binding]; other site 568707012335 Q-loop/lid; other site 568707012336 ABC transporter signature motif; other site 568707012337 Walker B; other site 568707012338 D-loop; other site 568707012339 H-loop/switch region; other site 568707012340 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568707012341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707012342 dimer interface [polypeptide binding]; other site 568707012343 conserved gate region; other site 568707012344 putative PBP binding loops; other site 568707012345 ABC-ATPase subunit interface; other site 568707012346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707012347 dimer interface [polypeptide binding]; other site 568707012348 conserved gate region; other site 568707012349 putative PBP binding loops; other site 568707012350 ABC-ATPase subunit interface; other site 568707012351 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707012352 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568707012353 substrate binding pocket [chemical binding]; other site 568707012354 membrane-bound complex binding site; other site 568707012355 hinge residues; other site 568707012356 D-cysteine desulfhydrase; Validated; Region: PRK03910 568707012357 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 568707012358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568707012359 catalytic residue [active] 568707012360 cell density-dependent motility repressor; Provisional; Region: PRK10082 568707012361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707012362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707012363 dimerization interface [polypeptide binding]; other site 568707012364 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 568707012365 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707012366 dimerization interface [polypeptide binding]; other site 568707012367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707012368 dimer interface [polypeptide binding]; other site 568707012369 phosphorylation site [posttranslational modification] 568707012370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707012371 ATP binding site [chemical binding]; other site 568707012372 G-X-G motif; other site 568707012373 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 568707012374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707012375 active site 568707012376 phosphorylation site [posttranslational modification] 568707012377 intermolecular recognition site; other site 568707012378 dimerization interface [polypeptide binding]; other site 568707012379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707012380 DNA binding site [nucleotide binding] 568707012381 Domain of unknown function (DUF305); Region: DUF305; pfam03713 568707012382 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 568707012383 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 568707012384 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 568707012385 tartrate dehydrogenase; Region: TTC; TIGR02089 568707012386 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 568707012387 transcriptional activator TtdR; Provisional; Region: PRK09801 568707012388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707012389 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 568707012390 putative effector binding pocket; other site 568707012391 putative dimerization interface [polypeptide binding]; other site 568707012392 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568707012393 Ligand Binding Site [chemical binding]; other site 568707012394 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568707012395 Ligand Binding Site [chemical binding]; other site 568707012396 Predicted membrane protein [Function unknown]; Region: COG2860 568707012397 UPF0126 domain; Region: UPF0126; pfam03458 568707012398 UPF0126 domain; Region: UPF0126; pfam03458 568707012399 glutamate dehydrogenase; Provisional; Region: PRK09414 568707012400 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 568707012401 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 568707012402 NAD(P) binding site [chemical binding]; other site 568707012403 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 568707012404 putative active site [active] 568707012405 putative catalytic site [active] 568707012406 putative DNA binding site [nucleotide binding]; other site 568707012407 putative phosphate binding site [ion binding]; other site 568707012408 metal binding site A [ion binding]; metal-binding site 568707012409 putative AP binding site [nucleotide binding]; other site 568707012410 putative metal binding site B [ion binding]; other site 568707012411 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568707012412 active site 568707012413 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 568707012414 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 568707012415 GatB domain; Region: GatB_Yqey; smart00845 568707012416 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568707012417 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 568707012418 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 568707012419 rod shape-determining protein MreB; Provisional; Region: PRK13927 568707012420 MreB and similar proteins; Region: MreB_like; cd10225 568707012421 nucleotide binding site [chemical binding]; other site 568707012422 Mg binding site [ion binding]; other site 568707012423 putative protofilament interaction site [polypeptide binding]; other site 568707012424 RodZ interaction site [polypeptide binding]; other site 568707012425 rod shape-determining protein MreC; Provisional; Region: PRK13922 568707012426 rod shape-determining protein MreC; Region: MreC; pfam04085 568707012427 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 568707012428 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 568707012429 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568707012430 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568707012431 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 568707012432 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 568707012433 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 568707012434 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 568707012435 transmembrane helices; other site 568707012436 division inhibitor protein; Provisional; Region: slmA; PRK09480 568707012437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707012438 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 568707012439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707012440 motif II; other site 568707012441 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 568707012442 feedback inhibition sensing region; other site 568707012443 homohexameric interface [polypeptide binding]; other site 568707012444 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 568707012445 nucleotide binding site [chemical binding]; other site 568707012446 N-acetyl-L-glutamate binding site [chemical binding]; other site 568707012447 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 568707012448 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568707012449 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 568707012450 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 568707012451 catalytic residues [active] 568707012452 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 568707012453 BON domain; Region: BON; pfam04972 568707012454 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 568707012455 active site 568707012456 dimer interface [polypeptide binding]; other site 568707012457 hypothetical protein; Provisional; Region: PRK14685 568707012458 Predicted methyltransferases [General function prediction only]; Region: COG0313 568707012459 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 568707012460 putative SAM binding site [chemical binding]; other site 568707012461 putative homodimer interface [polypeptide binding]; other site 568707012462 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 568707012463 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 568707012464 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 568707012465 DNA binding site [nucleotide binding] 568707012466 active site 568707012467 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 568707012468 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 568707012469 Sporulation related domain; Region: SPOR; pfam05036 568707012470 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 568707012471 AAA domain; Region: AAA_18; pfam13238 568707012472 Cytochrome c; Region: Cytochrom_C; cl11414 568707012473 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 568707012474 Cytochrome c; Region: Cytochrom_C; cl11414 568707012475 Cytochrome c; Region: Cytochrom_C; pfam00034 568707012476 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 568707012477 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 568707012478 Cytochrome c; Region: Cytochrom_C; pfam00034 568707012479 HPr kinase/phosphorylase; Provisional; Region: PRK05428 568707012480 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 568707012481 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 568707012482 Hpr binding site; other site 568707012483 active site 568707012484 homohexamer subunit interaction site [polypeptide binding]; other site 568707012485 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568707012486 active site 568707012487 phosphorylation site [posttranslational modification] 568707012488 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 568707012489 30S subunit binding site; other site 568707012490 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 568707012491 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 568707012492 Walker A/P-loop; other site 568707012493 ATP binding site [chemical binding]; other site 568707012494 Q-loop/lid; other site 568707012495 ABC transporter signature motif; other site 568707012496 Walker B; other site 568707012497 D-loop; other site 568707012498 H-loop/switch region; other site 568707012499 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 568707012500 OstA-like protein; Region: OstA; pfam03968 568707012501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 568707012502 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 568707012503 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 568707012504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707012505 active site 568707012506 motif I; other site 568707012507 motif II; other site 568707012508 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 568707012509 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 568707012510 putative active site [active] 568707012511 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 568707012512 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 568707012513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707012514 ATP-grasp domain; Region: ATP-grasp; pfam02222 568707012515 Predicted transcriptional regulators [Transcription]; Region: COG1510 568707012516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707012517 dimerization interface [polypeptide binding]; other site 568707012518 putative DNA binding site [nucleotide binding]; other site 568707012519 putative Zn2+ binding site [ion binding]; other site 568707012520 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 568707012521 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 568707012522 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 568707012523 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 568707012524 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 568707012525 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 568707012526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707012527 Walker A/P-loop; other site 568707012528 ATP binding site [chemical binding]; other site 568707012529 Q-loop/lid; other site 568707012530 ABC transporter signature motif; other site 568707012531 Walker B; other site 568707012532 D-loop; other site 568707012533 H-loop/switch region; other site 568707012534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707012535 Walker A/P-loop; other site 568707012536 ATP binding site [chemical binding]; other site 568707012537 ABC transporter; Region: ABC_tran; pfam00005 568707012538 Q-loop/lid; other site 568707012539 ABC transporter signature motif; other site 568707012540 Walker B; other site 568707012541 D-loop; other site 568707012542 H-loop/switch region; other site 568707012543 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 568707012544 active site 568707012545 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707012546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707012547 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568707012548 putative effector binding pocket; other site 568707012549 dimerization interface [polypeptide binding]; other site 568707012550 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 568707012551 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568707012552 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 568707012553 trimer interface [polypeptide binding]; other site 568707012554 eyelet of channel; other site 568707012555 threonine dehydratase; Reviewed; Region: PRK09224 568707012556 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 568707012557 tetramer interface [polypeptide binding]; other site 568707012558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707012559 catalytic residue [active] 568707012560 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 568707012561 putative Ile/Val binding site [chemical binding]; other site 568707012562 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 568707012563 putative Ile/Val binding site [chemical binding]; other site 568707012564 Predicted membrane protein [Function unknown]; Region: COG1238 568707012565 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 568707012566 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 568707012567 FAD binding domain; Region: FAD_binding_4; pfam01565 568707012568 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 568707012569 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 568707012570 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 568707012571 Cysteine-rich domain; Region: CCG; pfam02754 568707012572 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 568707012573 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707012574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707012575 DNA-binding site [nucleotide binding]; DNA binding site 568707012576 FCD domain; Region: FCD; pfam07729 568707012577 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707012578 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707012579 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 568707012580 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 568707012581 enoyl-CoA hydratase; Provisional; Region: PRK08290 568707012582 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707012583 substrate binding site [chemical binding]; other site 568707012584 oxyanion hole (OAH) forming residues; other site 568707012585 trimer interface [polypeptide binding]; other site 568707012586 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568707012587 salicylate hydroxylase; Provisional; Region: PRK08163 568707012588 Tripartite tricarboxylate transporter family receptor; Region: TctC; pfam03401 568707012589 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707012590 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707012591 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707012592 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 568707012593 putative active site [active] 568707012594 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 568707012595 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 568707012596 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 568707012597 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 568707012598 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568707012599 putative metal binding site [ion binding]; other site 568707012600 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707012601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707012602 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 568707012603 putative dimerization interface [polypeptide binding]; other site 568707012604 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 568707012605 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 568707012606 ligand binding site [chemical binding]; other site 568707012607 NAD binding site [chemical binding]; other site 568707012608 tetramer interface [polypeptide binding]; other site 568707012609 catalytic site [active] 568707012610 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 568707012611 L-serine binding site [chemical binding]; other site 568707012612 ACT domain interface; other site 568707012613 Predicted metal-binding protein [General function prediction only]; Region: COG3019 568707012614 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 568707012615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707012616 dimerization interface [polypeptide binding]; other site 568707012617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707012618 dimer interface [polypeptide binding]; other site 568707012619 phosphorylation site [posttranslational modification] 568707012620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707012621 ATP binding site [chemical binding]; other site 568707012622 G-X-G motif; other site 568707012623 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 568707012624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707012625 active site 568707012626 phosphorylation site [posttranslational modification] 568707012627 intermolecular recognition site; other site 568707012628 dimerization interface [polypeptide binding]; other site 568707012629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707012630 DNA binding site [nucleotide binding] 568707012631 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 568707012632 PAS domain; Region: PAS; smart00091 568707012633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707012634 dimer interface [polypeptide binding]; other site 568707012635 phosphorylation site [posttranslational modification] 568707012636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707012637 ATP binding site [chemical binding]; other site 568707012638 G-X-G motif; other site 568707012639 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 568707012640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707012641 active site 568707012642 phosphorylation site [posttranslational modification] 568707012643 intermolecular recognition site; other site 568707012644 dimerization interface [polypeptide binding]; other site 568707012645 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707012646 DNA binding site [nucleotide binding] 568707012647 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 568707012648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707012649 S-adenosylmethionine binding site [chemical binding]; other site 568707012650 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 568707012651 SCP-2 sterol transfer family; Region: SCP2; pfam02036 568707012652 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 568707012653 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 568707012654 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 568707012655 dinuclear metal binding motif [ion binding]; other site 568707012656 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 568707012657 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 568707012658 active site 568707012659 nucleotide binding site [chemical binding]; other site 568707012660 HIGH motif; other site 568707012661 KMSKS motif; other site 568707012662 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 568707012663 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 568707012664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707012665 S-adenosylmethionine binding site [chemical binding]; other site 568707012666 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 568707012667 dimer interface [polypeptide binding]; other site 568707012668 substrate binding site [chemical binding]; other site 568707012669 ATP binding site [chemical binding]; other site 568707012670 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 568707012671 ThiS interaction site; other site 568707012672 putative active site [active] 568707012673 tetramer interface [polypeptide binding]; other site 568707012674 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 568707012675 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 568707012676 cobalamin binding residues [chemical binding]; other site 568707012677 putative BtuC binding residues; other site 568707012678 dimer interface [polypeptide binding]; other site 568707012679 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 568707012680 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707012681 N-terminal plug; other site 568707012682 ligand-binding site [chemical binding]; other site 568707012683 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 568707012684 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 568707012685 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 568707012686 substrate binding pocket [chemical binding]; other site 568707012687 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 568707012688 B12 binding site [chemical binding]; other site 568707012689 cobalt ligand [ion binding]; other site 568707012690 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 568707012691 Methyltransferase domain; Region: Methyltransf_31; pfam13847 568707012692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707012693 S-adenosylmethionine binding site [chemical binding]; other site 568707012694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707012695 salt bridge; other site 568707012696 non-specific DNA binding site [nucleotide binding]; other site 568707012697 sequence-specific DNA binding site [nucleotide binding]; other site 568707012698 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 568707012699 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568707012700 minor groove reading motif; other site 568707012701 helix-hairpin-helix signature motif; other site 568707012702 substrate binding pocket [chemical binding]; other site 568707012703 active site 568707012704 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 568707012705 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 568707012706 DNA binding and oxoG recognition site [nucleotide binding] 568707012707 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 568707012708 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 568707012709 dimer interface [polypeptide binding]; other site 568707012710 PYR/PP interface [polypeptide binding]; other site 568707012711 TPP binding site [chemical binding]; other site 568707012712 substrate binding site [chemical binding]; other site 568707012713 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 568707012714 TPP-binding site; other site 568707012715 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 568707012716 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 568707012717 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 568707012718 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 568707012719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707012720 Walker A/P-loop; other site 568707012721 ATP binding site [chemical binding]; other site 568707012722 Q-loop/lid; other site 568707012723 ABC transporter signature motif; other site 568707012724 Walker B; other site 568707012725 D-loop; other site 568707012726 H-loop/switch region; other site 568707012727 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 568707012728 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 568707012729 substrate binding pocket [chemical binding]; other site 568707012730 membrane-bound complex binding site; other site 568707012731 hinge residues; other site 568707012732 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 568707012733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 568707012734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707012735 dimer interface [polypeptide binding]; other site 568707012736 conserved gate region; other site 568707012737 putative PBP binding loops; other site 568707012738 ABC-ATPase subunit interface; other site 568707012739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707012740 dimer interface [polypeptide binding]; other site 568707012741 conserved gate region; other site 568707012742 putative PBP binding loops; other site 568707012743 ABC-ATPase subunit interface; other site 568707012744 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568707012745 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 568707012746 Walker A/P-loop; other site 568707012747 ATP binding site [chemical binding]; other site 568707012748 Q-loop/lid; other site 568707012749 ABC transporter signature motif; other site 568707012750 Walker B; other site 568707012751 D-loop; other site 568707012752 H-loop/switch region; other site 568707012753 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707012754 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 568707012755 glycerol kinase; Provisional; Region: glpK; PRK00047 568707012756 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 568707012757 N- and C-terminal domain interface [polypeptide binding]; other site 568707012758 active site 568707012759 MgATP binding site [chemical binding]; other site 568707012760 catalytic site [active] 568707012761 metal binding site [ion binding]; metal-binding site 568707012762 glycerol binding site [chemical binding]; other site 568707012763 homotetramer interface [polypeptide binding]; other site 568707012764 homodimer interface [polypeptide binding]; other site 568707012765 FBP binding site [chemical binding]; other site 568707012766 protein IIAGlc interface [polypeptide binding]; other site 568707012767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707012768 putative substrate translocation pore; other site 568707012769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707012770 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 568707012771 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 568707012772 Pantoate-beta-alanine ligase; Region: PanC; cd00560 568707012773 pantoate--beta-alanine ligase; Region: panC; TIGR00018 568707012774 active site 568707012775 ATP-binding site [chemical binding]; other site 568707012776 pantoate-binding site; other site 568707012777 HXXH motif; other site 568707012778 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568707012779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 568707012780 DNA binding residues [nucleotide binding] 568707012781 dimerization interface [polypeptide binding]; other site 568707012782 NlpE N-terminal domain; Region: NlpE; pfam04170 568707012783 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 568707012784 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 568707012785 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 568707012786 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 568707012787 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 568707012788 CoA-binding site [chemical binding]; other site 568707012789 ATP-binding [chemical binding]; other site 568707012790 hypothetical protein; Provisional; Region: PRK05287 568707012791 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568707012792 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568707012793 HlyD family secretion protein; Region: HlyD_3; pfam13437 568707012794 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 568707012795 Protein export membrane protein; Region: SecD_SecF; cl14618 568707012796 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 568707012797 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 568707012798 hypothetical protein; Provisional; Region: PRK08999 568707012799 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 568707012800 active site 568707012801 8-oxo-dGMP binding site [chemical binding]; other site 568707012802 nudix motif; other site 568707012803 metal binding site [ion binding]; metal-binding site 568707012804 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 568707012805 active site 568707012806 thiamine phosphate binding site [chemical binding]; other site 568707012807 pyrophosphate binding site [ion binding]; other site 568707012808 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 568707012809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707012810 Walker A motif; other site 568707012811 ATP binding site [chemical binding]; other site 568707012812 Walker B motif; other site 568707012813 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 568707012814 heterotetramer interface [polypeptide binding]; other site 568707012815 active site pocket [active] 568707012816 cleavage site 568707012817 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 568707012818 MarR family; Region: MarR; pfam01047 568707012819 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 568707012820 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 568707012821 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707012822 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 568707012823 putative ligand binding site [chemical binding]; other site 568707012824 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707012825 TM-ABC transporter signature motif; other site 568707012826 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707012827 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707012828 TM-ABC transporter signature motif; other site 568707012829 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707012830 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707012831 Walker A/P-loop; other site 568707012832 ATP binding site [chemical binding]; other site 568707012833 Q-loop/lid; other site 568707012834 ABC transporter signature motif; other site 568707012835 Walker B; other site 568707012836 D-loop; other site 568707012837 H-loop/switch region; other site 568707012838 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707012839 ATP binding site [chemical binding]; other site 568707012840 Walker A/P-loop; other site 568707012841 ABC transporter; Region: ABC_tran; pfam00005 568707012842 Q-loop/lid; other site 568707012843 ABC transporter signature motif; other site 568707012844 Walker B; other site 568707012845 D-loop; other site 568707012846 H-loop/switch region; other site 568707012847 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 568707012848 hypothetical protein; Provisional; Region: PRK07236 568707012849 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 568707012850 active site 568707012851 FMN binding site [chemical binding]; other site 568707012852 substrate binding site [chemical binding]; other site 568707012853 homotetramer interface [polypeptide binding]; other site 568707012854 catalytic residue [active] 568707012855 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568707012856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707012857 NAD(P) binding site [chemical binding]; other site 568707012858 active site 568707012859 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 568707012860 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707012861 substrate binding site [chemical binding]; other site 568707012862 oxyanion hole (OAH) forming residues; other site 568707012863 trimer interface [polypeptide binding]; other site 568707012864 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 568707012865 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707012866 active site 568707012867 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707012868 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 568707012869 acyl-activating enzyme (AAE) consensus motif; other site 568707012870 AMP binding site [chemical binding]; other site 568707012871 active site 568707012872 CoA binding site [chemical binding]; other site 568707012873 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 568707012874 active site 568707012875 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568707012876 homotrimer interaction site [polypeptide binding]; other site 568707012877 putative active site [active] 568707012878 Protein of unknown function (DUF342); Region: DUF342; pfam03961 568707012879 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 568707012880 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 568707012881 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568707012882 inhibitor-cofactor binding pocket; inhibition site 568707012883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707012884 catalytic residue [active] 568707012885 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 568707012886 thiamine phosphate binding site [chemical binding]; other site 568707012887 active site 568707012888 pyrophosphate binding site [ion binding]; other site 568707012889 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 568707012890 substrate binding site [chemical binding]; other site 568707012891 dimer interface [polypeptide binding]; other site 568707012892 ATP binding site [chemical binding]; other site 568707012893 Rubredoxin [Energy production and conversion]; Region: COG1773 568707012894 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 568707012895 iron binding site [ion binding]; other site 568707012896 hypothetical protein; Validated; Region: PRK00228 568707012897 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 568707012898 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 568707012899 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 568707012900 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 568707012901 dihydroorotase; Provisional; Region: PRK07627 568707012902 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 568707012903 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 568707012904 active site 568707012905 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 568707012906 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568707012907 putative acyl-acceptor binding pocket; other site 568707012908 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 568707012909 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 568707012910 active site 568707012911 metal binding site [ion binding]; metal-binding site 568707012912 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 568707012913 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 568707012914 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 568707012915 Transglycosylase; Region: Transgly; cl17702 568707012916 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 568707012917 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568707012918 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568707012919 shikimate binding site; other site 568707012920 NAD(P) binding site [chemical binding]; other site 568707012921 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 568707012922 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 568707012923 RNB domain; Region: RNB; pfam00773 568707012924 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 568707012925 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568707012926 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 568707012927 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568707012928 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568707012929 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568707012930 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 568707012931 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 568707012932 catalytic residues [active] 568707012933 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 568707012934 Dehydroquinase class II; Region: DHquinase_II; pfam01220 568707012935 trimer interface [polypeptide binding]; other site 568707012936 active site 568707012937 dimer interface [polypeptide binding]; other site 568707012938 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 568707012939 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 568707012940 carboxyltransferase (CT) interaction site; other site 568707012941 biotinylation site [posttranslational modification]; other site 568707012942 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 568707012943 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568707012944 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 568707012945 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 568707012946 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 568707012947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707012948 S-adenosylmethionine binding site [chemical binding]; other site 568707012949 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 568707012950 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 568707012951 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568707012952 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 568707012953 substrate binding site [chemical binding]; other site 568707012954 ATP binding site [chemical binding]; other site 568707012955 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 568707012956 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 568707012957 DltD C-terminal region; Region: DltD_C; pfam04914 568707012958 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 568707012959 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 568707012960 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 568707012961 acyl-activating enzyme (AAE) consensus motif; other site 568707012962 AMP binding site [chemical binding]; other site 568707012963 YGGT family; Region: YGGT; pfam02325 568707012964 YGGT family; Region: YGGT; pfam02325 568707012965 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 568707012966 dimer interface [polypeptide binding]; other site 568707012967 putative radical transfer pathway; other site 568707012968 diiron center [ion binding]; other site 568707012969 tyrosyl radical; other site 568707012970 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 568707012971 ATP cone domain; Region: ATP-cone; pfam03477 568707012972 ATP cone domain; Region: ATP-cone; pfam03477 568707012973 Class I ribonucleotide reductase; Region: RNR_I; cd01679 568707012974 active site 568707012975 dimer interface [polypeptide binding]; other site 568707012976 catalytic residues [active] 568707012977 effector binding site; other site 568707012978 R2 peptide binding site; other site 568707012979 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 568707012980 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 568707012981 dimer interface [polypeptide binding]; other site 568707012982 PYR/PP interface [polypeptide binding]; other site 568707012983 TPP binding site [chemical binding]; other site 568707012984 substrate binding site [chemical binding]; other site 568707012985 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 568707012986 TPP-binding site [chemical binding]; other site 568707012987 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 568707012988 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568707012989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707012990 putative DNA binding site [nucleotide binding]; other site 568707012991 putative Zn2+ binding site [ion binding]; other site 568707012992 AsnC family; Region: AsnC_trans_reg; pfam01037 568707012993 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707012994 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 568707012995 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568707012996 HIGH motif; other site 568707012997 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568707012998 active site 568707012999 KMSKS motif; other site 568707013000 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 568707013001 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 568707013002 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 568707013003 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568707013004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707013005 Coenzyme A binding pocket [chemical binding]; other site 568707013006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707013007 DNA-binding site [nucleotide binding]; DNA binding site 568707013008 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568707013009 FCD domain; Region: FCD; pfam07729 568707013010 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 568707013011 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 568707013012 ATP binding site [chemical binding]; other site 568707013013 Mg++ binding site [ion binding]; other site 568707013014 motif III; other site 568707013015 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568707013016 nucleotide binding region [chemical binding]; other site 568707013017 ATP-binding site [chemical binding]; other site 568707013018 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 568707013019 putative RNA binding site [nucleotide binding]; other site 568707013020 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 568707013021 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568707013022 Isochorismatase family; Region: Isochorismatase; pfam00857 568707013023 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 568707013024 catalytic triad [active] 568707013025 conserved cis-peptide bond; other site 568707013026 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707013027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707013028 dimer interface [polypeptide binding]; other site 568707013029 conserved gate region; other site 568707013030 putative PBP binding loops; other site 568707013031 ABC-ATPase subunit interface; other site 568707013032 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707013033 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707013034 Walker A/P-loop; other site 568707013035 ATP binding site [chemical binding]; other site 568707013036 Q-loop/lid; other site 568707013037 ABC transporter signature motif; other site 568707013038 Walker B; other site 568707013039 D-loop; other site 568707013040 H-loop/switch region; other site 568707013041 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568707013042 NMT1/THI5 like; Region: NMT1; pfam09084 568707013043 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 568707013044 putative hydrolase; Provisional; Region: PRK11460 568707013045 hypothetical protein; Provisional; Region: PRK05255 568707013046 peptidase PmbA; Provisional; Region: PRK11040 568707013047 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 568707013048 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707013049 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 568707013050 23S rRNA interface [nucleotide binding]; other site 568707013051 L3 interface [polypeptide binding]; other site 568707013052 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 568707013053 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 568707013054 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 568707013055 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 568707013056 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 568707013057 putative peptidase; Provisional; Region: PRK11649 568707013058 Peptidase family M23; Region: Peptidase_M23; pfam01551 568707013059 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 568707013060 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 568707013061 active site 568707013062 HIGH motif; other site 568707013063 dimer interface [polypeptide binding]; other site 568707013064 KMSKS motif; other site 568707013065 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568707013066 RNA binding surface [nucleotide binding]; other site 568707013067 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 568707013068 substrate binding site [chemical binding]; other site 568707013069 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 568707013070 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 568707013071 dimer interface [polypeptide binding]; other site 568707013072 active site 568707013073 glycine-pyridoxal phosphate binding site [chemical binding]; other site 568707013074 folate binding site [chemical binding]; other site 568707013075 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 568707013076 ATP cone domain; Region: ATP-cone; pfam03477 568707013077 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 568707013078 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 568707013079 conserved cys residue [active] 568707013080 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 568707013081 catalytic triad [active] 568707013082 conserved cis-peptide bond; other site 568707013083 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 568707013084 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 568707013085 catalytic motif [active] 568707013086 Zn binding site [ion binding]; other site 568707013087 RibD C-terminal domain; Region: RibD_C; cl17279 568707013088 PrkA family serine protein kinase; Provisional; Region: PRK15455 568707013089 AAA ATPase domain; Region: AAA_16; pfam13191 568707013090 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 568707013091 hypothetical protein; Provisional; Region: PRK05325 568707013092 SpoVR family protein; Provisional; Region: PRK11767 568707013093 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 568707013094 D-galactonate transporter; Region: 2A0114; TIGR00893 568707013095 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 568707013096 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013097 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 568707013098 dimer interface [polypeptide binding]; other site 568707013099 Methylaspartate ammonia-lyase C-terminus; Region: MAAL_C; pfam07476 568707013100 active site 568707013101 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707013102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707013103 DNA-binding site [nucleotide binding]; DNA binding site 568707013104 UTRA domain; Region: UTRA; pfam07702 568707013105 Uncharacterized conserved protein [Function unknown]; Region: COG3791 568707013106 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 568707013107 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707013108 catalytic loop [active] 568707013109 iron binding site [ion binding]; other site 568707013111 UreD urease accessory protein; Region: UreD; cl00530 568707013112 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 568707013113 alpha-gamma subunit interface [polypeptide binding]; other site 568707013114 beta-gamma subunit interface [polypeptide binding]; other site 568707013115 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 568707013116 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 568707013117 gamma-beta subunit interface [polypeptide binding]; other site 568707013118 alpha-beta subunit interface [polypeptide binding]; other site 568707013119 urease subunit alpha; Reviewed; Region: ureC; PRK13207 568707013120 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 568707013121 subunit interactions [polypeptide binding]; other site 568707013122 active site 568707013123 flap region; other site 568707013124 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 568707013125 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 568707013126 dimer interface [polypeptide binding]; other site 568707013127 catalytic residues [active] 568707013128 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 568707013129 UreF; Region: UreF; pfam01730 568707013130 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 568707013131 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707013132 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 568707013133 tetramerization interface [polypeptide binding]; other site 568707013134 NAD(P) binding site [chemical binding]; other site 568707013135 catalytic residues [active] 568707013136 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 568707013137 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 568707013138 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 568707013139 hydrophobic ligand binding site; other site 568707013140 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 568707013141 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 568707013142 FMN-binding pocket [chemical binding]; other site 568707013143 flavin binding motif; other site 568707013144 phosphate binding motif [ion binding]; other site 568707013145 beta-alpha-beta structure motif; other site 568707013146 NAD binding pocket [chemical binding]; other site 568707013147 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707013148 catalytic loop [active] 568707013149 iron binding site [ion binding]; other site 568707013150 choline dehydrogenase; Validated; Region: PRK02106 568707013151 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 568707013152 Sulfatase; Region: Sulfatase; cl17466 568707013153 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 568707013154 gating phenylalanine in ion channel; other site 568707013155 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707013156 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707013157 DNA-binding site [nucleotide binding]; DNA binding site 568707013158 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013159 NMT1-like family; Region: NMT1_2; pfam13379 568707013160 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568707013161 membrane-bound complex binding site; other site 568707013162 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707013163 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707013164 DNA-binding site [nucleotide binding]; DNA binding site 568707013165 UTRA domain; Region: UTRA; cl17743 568707013166 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707013167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707013168 dimer interface [polypeptide binding]; other site 568707013169 conserved gate region; other site 568707013170 putative PBP binding loops; other site 568707013171 ABC-ATPase subunit interface; other site 568707013172 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568707013173 NMT1/THI5 like; Region: NMT1; pfam09084 568707013174 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707013175 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707013176 Walker A/P-loop; other site 568707013177 ATP binding site [chemical binding]; other site 568707013178 Q-loop/lid; other site 568707013179 ABC transporter signature motif; other site 568707013180 Walker B; other site 568707013181 D-loop; other site 568707013182 H-loop/switch region; other site 568707013183 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707013184 enoyl-CoA hydratase; Provisional; Region: PRK06494 568707013185 substrate binding site [chemical binding]; other site 568707013186 oxyanion hole (OAH) forming residues; other site 568707013187 trimer interface [polypeptide binding]; other site 568707013188 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 568707013189 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013190 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 568707013191 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 568707013192 NAD(P) binding site [chemical binding]; other site 568707013193 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707013194 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707013195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707013196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707013197 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 568707013198 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 568707013199 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 568707013200 putative NADH binding site [chemical binding]; other site 568707013201 putative active site [active] 568707013202 nudix motif; other site 568707013203 putative metal binding site [ion binding]; other site 568707013204 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 568707013205 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 568707013206 FMN-binding pocket [chemical binding]; other site 568707013207 flavin binding motif; other site 568707013208 phosphate binding motif [ion binding]; other site 568707013209 beta-alpha-beta structure motif; other site 568707013210 NAD binding pocket [chemical binding]; other site 568707013211 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707013212 catalytic loop [active] 568707013213 iron binding site [ion binding]; other site 568707013214 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568707013215 Amidase; Region: Amidase; cl11426 568707013216 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 568707013217 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 568707013218 NAD(P) binding site [chemical binding]; other site 568707013219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707013220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707013221 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 568707013222 putative substrate binding pocket [chemical binding]; other site 568707013223 dimerization interface [polypeptide binding]; other site 568707013224 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707013225 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 568707013226 putative ligand binding site [chemical binding]; other site 568707013227 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 568707013228 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707013229 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707013230 Walker A/P-loop; other site 568707013231 ATP binding site [chemical binding]; other site 568707013232 Q-loop/lid; other site 568707013233 ABC transporter signature motif; other site 568707013234 Walker B; other site 568707013235 D-loop; other site 568707013236 H-loop/switch region; other site 568707013237 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707013238 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707013239 Walker A/P-loop; other site 568707013240 ATP binding site [chemical binding]; other site 568707013241 Q-loop/lid; other site 568707013242 ABC transporter signature motif; other site 568707013243 Walker B; other site 568707013244 D-loop; other site 568707013245 H-loop/switch region; other site 568707013246 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707013247 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707013248 TM-ABC transporter signature motif; other site 568707013249 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707013250 TM-ABC transporter signature motif; other site 568707013251 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 568707013252 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 568707013253 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 568707013254 alpha subunit interface [polypeptide binding]; other site 568707013255 active site 568707013256 substrate binding site [chemical binding]; other site 568707013257 Fe binding site [ion binding]; other site 568707013258 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 568707013259 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 568707013260 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 568707013261 dimerization interface [polypeptide binding]; other site 568707013262 active site 568707013263 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013264 Protein of unknown function (DUF533); Region: DUF533; pfam04391 568707013265 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 568707013266 putative metal binding site [ion binding]; other site 568707013267 OsmC-like protein; Region: OsmC; pfam02566 568707013268 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 568707013269 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 568707013270 NAD binding site [chemical binding]; other site 568707013271 homotetramer interface [polypeptide binding]; other site 568707013272 homodimer interface [polypeptide binding]; other site 568707013273 substrate binding site [chemical binding]; other site 568707013274 active site 568707013275 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 568707013276 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568707013277 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568707013278 catalytic residue [active] 568707013279 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568707013280 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 568707013281 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 568707013282 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 568707013283 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 568707013284 RNA/DNA hybrid binding site [nucleotide binding]; other site 568707013285 active site 568707013286 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568707013287 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568707013288 HlyD family secretion protein; Region: HlyD_3; pfam13437 568707013289 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 568707013290 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 568707013291 active site 568707013292 catalytic site [active] 568707013293 substrate binding site [chemical binding]; other site 568707013294 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 568707013295 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 568707013296 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 568707013297 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 568707013298 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 568707013299 Ligand binding site; other site 568707013300 Putative Catalytic site; other site 568707013301 DXD motif; other site 568707013302 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 568707013303 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 568707013304 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 568707013305 putative active site [active] 568707013306 YdjC motif; other site 568707013307 Mg binding site [ion binding]; other site 568707013308 putative homodimer interface [polypeptide binding]; other site 568707013309 Predicted membrane protein [Function unknown]; Region: COG4125 568707013310 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 568707013311 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 568707013312 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 568707013313 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 568707013314 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 568707013315 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568707013316 EamA-like transporter family; Region: EamA; pfam00892 568707013317 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 568707013318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707013319 DNA-binding site [nucleotide binding]; DNA binding site 568707013320 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707013321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707013322 homodimer interface [polypeptide binding]; other site 568707013323 catalytic residue [active] 568707013324 Putative phosphatase (DUF442); Region: DUF442; cl17385 568707013325 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568707013326 Ligand Binding Site [chemical binding]; other site 568707013327 elongation factor G; Reviewed; Region: PRK00007 568707013328 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 568707013329 G1 box; other site 568707013330 putative GEF interaction site [polypeptide binding]; other site 568707013331 GTP/Mg2+ binding site [chemical binding]; other site 568707013332 Switch I region; other site 568707013333 G2 box; other site 568707013334 G3 box; other site 568707013335 Switch II region; other site 568707013336 G4 box; other site 568707013337 G5 box; other site 568707013338 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 568707013339 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 568707013340 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 568707013341 MgtC family; Region: MgtC; pfam02308 568707013342 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 568707013343 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707013344 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707013345 enoyl-CoA hydratase; Provisional; Region: PRK09245 568707013346 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707013347 substrate binding site [chemical binding]; other site 568707013348 oxyanion hole (OAH) forming residues; other site 568707013349 trimer interface [polypeptide binding]; other site 568707013350 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013351 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 568707013352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707013353 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 568707013354 dimerization interface [polypeptide binding]; other site 568707013355 substrate binding pocket [chemical binding]; other site 568707013356 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 568707013357 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707013358 active site 568707013359 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 568707013360 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568707013361 dimer interface [polypeptide binding]; other site 568707013362 active site 568707013363 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 568707013364 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 568707013365 acyl-activating enzyme (AAE) consensus motif; other site 568707013366 putative AMP binding site [chemical binding]; other site 568707013367 putative active site [active] 568707013368 putative CoA binding site [chemical binding]; other site 568707013369 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013370 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 568707013371 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 568707013372 catalytic site [active] 568707013373 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 568707013374 putative deacylase active site [active] 568707013375 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568707013376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568707013377 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568707013378 MarR family; Region: MarR_2; pfam12802 568707013379 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 568707013380 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 568707013381 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013382 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 568707013383 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 568707013384 Walker A/P-loop; other site 568707013385 ATP binding site [chemical binding]; other site 568707013386 Q-loop/lid; other site 568707013387 ABC transporter signature motif; other site 568707013388 Walker B; other site 568707013389 D-loop; other site 568707013390 H-loop/switch region; other site 568707013391 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 568707013392 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 568707013393 ABC-ATPase subunit interface; other site 568707013394 dimer interface [polypeptide binding]; other site 568707013395 putative PBP binding regions; other site 568707013396 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 568707013397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 568707013398 binding surface 568707013399 TPR motif; other site 568707013400 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 568707013401 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568707013402 ligand binding site [chemical binding]; other site 568707013403 translocation protein TolB; Provisional; Region: tolB; PRK02889 568707013404 TolB amino-terminal domain; Region: TolB_N; pfam04052 568707013405 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 568707013406 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 568707013407 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 568707013408 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 568707013409 TolA protein; Region: tolA_full; TIGR02794 568707013410 TonB C terminal; Region: TonB_2; pfam13103 568707013411 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 568707013412 TolR protein; Region: tolR; TIGR02801 568707013413 TolQ protein; Region: tolQ; TIGR02796 568707013414 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 568707013415 active site 568707013416 prolyl-tRNA synthetase; Provisional; Region: PRK09194 568707013417 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 568707013418 dimer interface [polypeptide binding]; other site 568707013419 motif 1; other site 568707013420 active site 568707013421 motif 2; other site 568707013422 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 568707013423 putative deacylase active site [active] 568707013424 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568707013425 active site 568707013426 motif 3; other site 568707013427 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 568707013428 anticodon binding site; other site 568707013429 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 568707013430 putative active site [active] 568707013431 Ap4A binding site [chemical binding]; other site 568707013432 nudix motif; other site 568707013433 putative metal binding site [ion binding]; other site 568707013434 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 568707013435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707013436 active site 568707013437 phosphorylation site [posttranslational modification] 568707013438 intermolecular recognition site; other site 568707013439 dimerization interface [polypeptide binding]; other site 568707013440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707013441 DNA binding site [nucleotide binding] 568707013442 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 568707013443 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568707013444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707013445 dimer interface [polypeptide binding]; other site 568707013446 phosphorylation site [posttranslational modification] 568707013447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707013448 ATP binding site [chemical binding]; other site 568707013449 Mg2+ binding site [ion binding]; other site 568707013450 G-X-G motif; other site 568707013451 Protein of unknown function (DUF3120); Region: DUF3220; pfam11516 568707013452 Tir chaperone protein (CesT) family; Region: CesT; cl08444 568707013453 LysR family transcriptional regulator; Provisional; Region: PRK14997 568707013454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707013455 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 568707013456 putative effector binding pocket; other site 568707013457 putative dimerization interface [polypeptide binding]; other site 568707013458 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 568707013459 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 568707013460 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568707013461 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568707013462 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 568707013463 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 568707013464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 568707013465 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 568707013466 Cell division protein ZapA; Region: ZapA; pfam05164 568707013467 Protein of unknown function (DUF541); Region: SIMPL; cl01077 568707013468 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 568707013469 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 568707013470 Cytochrome c; Region: Cytochrom_C; cl11414 568707013471 methionine sulfoxide reductase A; Provisional; Region: PRK14054 568707013472 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 568707013473 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 568707013474 dimer interface [polypeptide binding]; other site 568707013475 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 568707013476 active site 568707013477 Fe binding site [ion binding]; other site 568707013478 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 568707013479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707013480 dimerization interface [polypeptide binding]; other site 568707013481 putative DNA binding site [nucleotide binding]; other site 568707013482 putative Zn2+ binding site [ion binding]; other site 568707013483 AsnC family; Region: AsnC_trans_reg; pfam01037 568707013484 Predicted membrane protein [Function unknown]; Region: COG3671 568707013485 SWI complex, BAF60b domains; Region: SWIB; smart00151 568707013486 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 568707013487 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 568707013488 metal binding site [ion binding]; metal-binding site 568707013489 putative dimer interface [polypeptide binding]; other site 568707013490 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 568707013491 active site 568707013492 substrate binding pocket [chemical binding]; other site 568707013493 dimer interface [polypeptide binding]; other site 568707013494 ABC transporter ATPase component; Reviewed; Region: PRK11147 568707013495 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568707013496 ABC transporter; Region: ABC_tran_2; pfam12848 568707013497 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568707013498 cell division protein MraZ; Reviewed; Region: PRK00326 568707013499 MraZ protein; Region: MraZ; pfam02381 568707013500 MraZ protein; Region: MraZ; pfam02381 568707013501 MraW methylase family; Region: Methyltransf_5; cl17771 568707013502 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 568707013503 cell division protein FtsL; Region: ftsL_broad; TIGR02209 568707013504 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 568707013505 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568707013506 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 568707013507 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 568707013508 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568707013509 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568707013510 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568707013511 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568707013512 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568707013513 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568707013514 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 568707013515 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 568707013516 Mg++ binding site [ion binding]; other site 568707013517 putative catalytic motif [active] 568707013518 putative substrate binding site [chemical binding]; other site 568707013519 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 568707013520 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568707013521 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568707013522 cell division protein FtsW; Region: ftsW; TIGR02614 568707013523 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 568707013524 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 568707013525 active site 568707013526 homodimer interface [polypeptide binding]; other site 568707013527 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 568707013528 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568707013529 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568707013530 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568707013531 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 568707013532 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 568707013533 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568707013534 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 568707013535 Cell division protein FtsQ; Region: FtsQ; pfam03799 568707013536 cell division protein FtsA; Region: ftsA; TIGR01174 568707013537 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 568707013538 nucleotide binding site [chemical binding]; other site 568707013539 Cell division protein FtsA; Region: FtsA; pfam14450 568707013540 cell division protein FtsZ; Validated; Region: PRK09330 568707013541 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 568707013542 nucleotide binding site [chemical binding]; other site 568707013543 SulA interaction site; other site 568707013544 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 568707013545 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 568707013546 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 568707013547 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 568707013548 Peptidase family M23; Region: Peptidase_M23; pfam01551 568707013549 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 568707013550 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 568707013551 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 568707013552 nucleotide binding region [chemical binding]; other site 568707013553 ATP-binding site [chemical binding]; other site 568707013554 SEC-C motif; Region: SEC-C; pfam02810 568707013555 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 568707013556 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013557 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 568707013558 short chain dehydrogenase; Provisional; Region: PRK08339 568707013559 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 568707013560 putative NAD(P) binding site [chemical binding]; other site 568707013561 putative active site [active] 568707013562 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 568707013563 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 568707013564 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 568707013565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707013566 putative DNA binding site [nucleotide binding]; other site 568707013567 putative Zn2+ binding site [ion binding]; other site 568707013568 AsnC family; Region: AsnC_trans_reg; pfam01037 568707013569 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 568707013570 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 568707013571 putative active site pocket [active] 568707013572 dimerization interface [polypeptide binding]; other site 568707013573 putative catalytic residue [active] 568707013574 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 568707013575 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 568707013576 MgtE intracellular N domain; Region: MgtE_N; smart00924 568707013577 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 568707013578 Divalent cation transporter; Region: MgtE; pfam01769 568707013579 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 568707013580 Predicted membrane protein [Function unknown]; Region: COG2855 568707013581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707013582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707013583 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 568707013584 putative dimerization interface [polypeptide binding]; other site 568707013585 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 568707013586 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 568707013587 metal binding site [ion binding]; metal-binding site 568707013588 putative dimer interface [polypeptide binding]; other site 568707013589 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 568707013590 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707013591 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 568707013592 acyl-activating enzyme (AAE) consensus motif; other site 568707013593 putative AMP binding site [chemical binding]; other site 568707013594 putative active site [active] 568707013595 putative CoA binding site [chemical binding]; other site 568707013596 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 568707013597 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 568707013598 active site 568707013599 dimerization interface [polypeptide binding]; other site 568707013600 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 568707013601 Uncharacterized conserved protein [Function unknown]; Region: COG4121 568707013602 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 568707013603 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 568707013604 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 568707013605 active site 568707013606 catalytic site [active] 568707013607 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 568707013608 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 568707013609 Walker A/P-loop; other site 568707013610 ATP binding site [chemical binding]; other site 568707013611 Q-loop/lid; other site 568707013612 ABC transporter signature motif; other site 568707013613 Walker B; other site 568707013614 D-loop; other site 568707013615 H-loop/switch region; other site 568707013616 NIL domain; Region: NIL; pfam09383 568707013617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707013618 ABC-ATPase subunit interface; other site 568707013619 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 568707013620 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 568707013621 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 568707013622 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 568707013623 active site 568707013624 NAD binding site [chemical binding]; other site 568707013625 metal binding site [ion binding]; metal-binding site 568707013626 Uncharacterized conserved protein [Function unknown]; Region: COG1359 568707013627 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 568707013628 substrate binding site [chemical binding]; other site 568707013629 Protein of unknown function (DUF521); Region: DUF521; pfam04412 568707013630 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 568707013631 substrate binding site [chemical binding]; other site 568707013632 ligand binding site [chemical binding]; other site 568707013633 Transcriptional regulators [Transcription]; Region: FadR; COG2186 568707013634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707013635 DNA-binding site [nucleotide binding]; DNA binding site 568707013636 FCD domain; Region: FCD; pfam07729 568707013637 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013638 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 568707013639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707013640 dimer interface [polypeptide binding]; other site 568707013641 conserved gate region; other site 568707013642 putative PBP binding loops; other site 568707013643 ABC-ATPase subunit interface; other site 568707013644 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568707013645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707013646 dimer interface [polypeptide binding]; other site 568707013647 conserved gate region; other site 568707013648 putative PBP binding loops; other site 568707013649 ABC-ATPase subunit interface; other site 568707013650 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 568707013651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707013652 Walker A/P-loop; other site 568707013653 ATP binding site [chemical binding]; other site 568707013654 Q-loop/lid; other site 568707013655 ABC transporter signature motif; other site 568707013656 Walker B; other site 568707013657 D-loop; other site 568707013658 H-loop/switch region; other site 568707013659 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568707013660 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 568707013661 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568707013662 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 568707013663 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707013664 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707013665 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 568707013666 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 568707013667 DNA binding residues [nucleotide binding] 568707013668 dimer interface [polypeptide binding]; other site 568707013669 [2Fe-2S] cluster binding site [ion binding]; other site 568707013670 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 568707013671 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 568707013672 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 568707013673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707013674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707013675 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 568707013676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707013677 NAD(P) binding site [chemical binding]; other site 568707013678 active site 568707013680 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568707013681 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568707013682 PydA is a Class III Extradiol ring-cleavage dioxygenase required for the degradation of 3-hydroxy-4-pyridone (HP); Region: PydA_Rs_like; cd07369 568707013683 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 568707013684 putative active site [active] 568707013685 Fe(II) binding site [ion binding]; other site 568707013686 putative dimer interface [polypeptide binding]; other site 568707013687 putative tetramer interface [polypeptide binding]; other site 568707013688 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 568707013689 homotrimer interaction site [polypeptide binding]; other site 568707013690 putative active site [active] 568707013691 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568707013692 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013693 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 568707013694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707013695 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707013696 dimerization interface [polypeptide binding]; other site 568707013697 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 568707013698 inter-subunit interface; other site 568707013699 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 568707013700 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 568707013701 iron-sulfur cluster [ion binding]; other site 568707013702 [2Fe-2S] cluster binding site [ion binding]; other site 568707013703 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 568707013704 putative alpha subunit interface [polypeptide binding]; other site 568707013705 putative active site [active] 568707013706 putative substrate binding site [chemical binding]; other site 568707013707 Fe binding site [ion binding]; other site 568707013708 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568707013709 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568707013710 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 568707013711 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 568707013712 Uncharacterized conserved protein [Function unknown]; Region: COG2353 568707013713 Secretin and TonB N terminus short domain; Region: STN; smart00965 568707013714 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 568707013715 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707013716 N-terminal plug; other site 568707013717 ligand-binding site [chemical binding]; other site 568707013718 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 568707013719 FecR protein; Region: FecR; pfam04773 568707013720 RNA polymerase sigma factor; Reviewed; Region: PRK12527 568707013721 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707013722 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568707013723 DNA binding residues [nucleotide binding] 568707013724 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 568707013725 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 568707013726 NAD(P) binding pocket [chemical binding]; other site 568707013727 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 568707013728 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 568707013729 dimer interface [polypeptide binding]; other site 568707013730 active site 568707013731 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568707013732 catalytic residues [active] 568707013733 substrate binding site [chemical binding]; other site 568707013734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707013735 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707013736 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707013737 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707013738 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 568707013739 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 568707013740 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707013741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707013742 dimer interface [polypeptide binding]; other site 568707013743 conserved gate region; other site 568707013744 putative PBP binding loops; other site 568707013745 ABC-ATPase subunit interface; other site 568707013746 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568707013747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707013748 dimer interface [polypeptide binding]; other site 568707013749 conserved gate region; other site 568707013750 putative PBP binding loops; other site 568707013751 ABC-ATPase subunit interface; other site 568707013752 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 568707013753 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707013754 Walker A/P-loop; other site 568707013755 ATP binding site [chemical binding]; other site 568707013756 Q-loop/lid; other site 568707013757 ABC transporter signature motif; other site 568707013758 Walker B; other site 568707013759 D-loop; other site 568707013760 H-loop/switch region; other site 568707013761 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707013762 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707013763 Walker A/P-loop; other site 568707013764 ATP binding site [chemical binding]; other site 568707013765 Q-loop/lid; other site 568707013766 ABC transporter signature motif; other site 568707013767 Walker B; other site 568707013768 D-loop; other site 568707013769 H-loop/switch region; other site 568707013770 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707013771 amidase; Provisional; Region: PRK07487 568707013772 Amidase; Region: Amidase; cl11426 568707013773 aminotransferase; Validated; Region: PRK07678 568707013774 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 568707013775 inhibitor-cofactor binding pocket; inhibition site 568707013776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707013777 catalytic residue [active] 568707013778 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 568707013779 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 568707013780 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 568707013781 tetramer interface [polypeptide binding]; other site 568707013782 active site 568707013783 Mg2+/Mn2+ binding site [ion binding]; other site 568707013784 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 568707013785 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 568707013786 ligand binding site [chemical binding]; other site 568707013787 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 568707013788 aromatic arch; other site 568707013789 DCoH dimer interaction site [polypeptide binding]; other site 568707013790 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 568707013791 DCoH tetramer interaction site [polypeptide binding]; other site 568707013792 substrate binding site [chemical binding]; other site 568707013793 hypothetical protein; Validated; Region: PRK09039 568707013794 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 568707013795 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 568707013796 Substrate binding site; other site 568707013797 metal-binding site 568707013798 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 568707013799 Phosphotransferase enzyme family; Region: APH; pfam01636 568707013800 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 568707013801 Organic solvent tolerance protein; Region: OstA_C; pfam04453 568707013802 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 568707013803 SurA N-terminal domain; Region: SurA_N; pfam09312 568707013804 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568707013805 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568707013806 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 568707013807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707013808 S-adenosylmethionine binding site [chemical binding]; other site 568707013809 glycerate kinase; Region: TIGR00045 568707013810 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 568707013811 pyruvate kinase; Provisional; Region: PRK05826 568707013812 domain interfaces; other site 568707013813 active site 568707013814 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 568707013815 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 568707013816 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 568707013817 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707013818 active site 568707013819 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 568707013820 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 568707013821 active site 568707013822 catalytic residues [active] 568707013823 metal binding site [ion binding]; metal-binding site 568707013824 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 568707013825 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 568707013826 dimer interface [polypeptide binding]; other site 568707013827 active site 568707013828 metal binding site [ion binding]; metal-binding site 568707013829 glutathione binding site [chemical binding]; other site 568707013830 Protein of unknown function DUF45; Region: DUF45; pfam01863 568707013831 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 568707013832 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568707013833 putative acyl-acceptor binding pocket; other site 568707013834 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 568707013835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707013836 active site 568707013837 motif I; other site 568707013838 motif II; other site 568707013839 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 568707013840 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 568707013841 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 568707013842 dimer interface [polypeptide binding]; other site 568707013843 motif 1; other site 568707013844 active site 568707013845 motif 2; other site 568707013846 motif 3; other site 568707013847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707013848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707013849 putative substrate translocation pore; other site 568707013850 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 568707013851 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 568707013852 tetramer interface [polypeptide binding]; other site 568707013853 active site 568707013854 Mg2+/Mn2+ binding site [ion binding]; other site 568707013855 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 568707013856 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 568707013857 substrate binding site [chemical binding]; other site 568707013858 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 568707013859 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 568707013860 substrate binding site [chemical binding]; other site 568707013861 ligand binding site [chemical binding]; other site 568707013862 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707013863 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707013864 DNA-binding site [nucleotide binding]; DNA binding site 568707013865 UTRA domain; Region: UTRA; pfam07702 568707013866 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013867 enoyl-CoA hydratase; Provisional; Region: PRK08252 568707013868 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707013869 substrate binding site [chemical binding]; other site 568707013870 oxyanion hole (OAH) forming residues; other site 568707013871 trimer interface [polypeptide binding]; other site 568707013872 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 568707013873 Fumarase C-terminus; Region: Fumerase_C; pfam05683 568707013874 Uncharacterized conserved protein [Function unknown]; Region: COG3777 568707013875 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707013876 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568707013877 active site 2 [active] 568707013878 active site 1 [active] 568707013879 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707013880 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707013881 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 568707013882 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 568707013883 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 568707013884 substrate binding site [chemical binding]; other site 568707013885 ATP binding site [chemical binding]; other site 568707013886 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013887 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568707013888 classical (c) SDRs; Region: SDR_c; cd05233 568707013889 NAD(P) binding site [chemical binding]; other site 568707013890 active site 568707013891 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568707013892 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568707013893 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 568707013894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707013895 NAD(P) binding site [chemical binding]; other site 568707013896 active site 568707013897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 568707013898 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 568707013899 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 568707013900 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 568707013901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707013902 DNA-binding site [nucleotide binding]; DNA binding site 568707013903 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707013904 FCD domain; Region: FCD; pfam07729 568707013905 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707013906 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 568707013907 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707013908 DctM-like transporters; Region: DctM; pfam06808 568707013909 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 568707013910 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 568707013911 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013912 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 568707013913 catalytic center binding site [active] 568707013914 ATP binding site [chemical binding]; other site 568707013915 poly(A) polymerase; Region: pcnB; TIGR01942 568707013916 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 568707013917 active site 568707013918 NTP binding site [chemical binding]; other site 568707013919 metal binding triad [ion binding]; metal-binding site 568707013920 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 568707013921 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 568707013922 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 568707013923 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 568707013924 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 568707013925 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 568707013926 Walker A motif; other site 568707013927 ATP binding site [chemical binding]; other site 568707013928 Walker B motif; other site 568707013929 arginine finger; other site 568707013930 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 568707013931 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 568707013932 dimerization interface [polypeptide binding]; other site 568707013933 putative ATP binding site [chemical binding]; other site 568707013934 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 568707013935 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 568707013936 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 568707013937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707013938 ATP binding site [chemical binding]; other site 568707013939 Mg2+ binding site [ion binding]; other site 568707013940 G-X-G motif; other site 568707013941 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 568707013942 ATP binding site [chemical binding]; other site 568707013943 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 568707013944 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 568707013945 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568707013946 AMIN domain; Region: AMIN; pfam11741 568707013947 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 568707013948 active site 568707013949 metal binding site [ion binding]; metal-binding site 568707013950 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 568707013951 fumarate hydratase; Reviewed; Region: fumC; PRK00485 568707013952 Class II fumarases; Region: Fumarase_classII; cd01362 568707013953 active site 568707013954 tetramer interface [polypeptide binding]; other site 568707013955 Predicted permeases [General function prediction only]; Region: COG0679 568707013956 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013957 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707013958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707013959 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707013960 dimerization interface [polypeptide binding]; other site 568707013961 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 568707013962 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 568707013963 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707013964 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707013965 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707013966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 568707013967 active site 568707013968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707013969 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 568707013970 putative dimerization interface [polypeptide binding]; other site 568707013971 putative substrate binding pocket [chemical binding]; other site 568707013972 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 568707013973 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 568707013974 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 568707013975 putative active site [active] 568707013976 putative substrate binding site [chemical binding]; other site 568707013977 putative cosubstrate binding site; other site 568707013978 catalytic site [active] 568707013979 Predicted dehydrogenase [General function prediction only]; Region: COG0579 568707013980 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568707013981 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 568707013982 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 568707013983 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 568707013984 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 568707013985 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 568707013986 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 568707013987 putative active site pocket [active] 568707013988 dimerization interface [polypeptide binding]; other site 568707013989 putative catalytic residue [active] 568707013990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707013991 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707013992 putative substrate translocation pore; other site 568707013993 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 568707013994 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 568707013995 putative ATP binding site [chemical binding]; other site 568707013996 putative substrate interface [chemical binding]; other site 568707013997 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707013998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707013999 DNA-binding site [nucleotide binding]; DNA binding site 568707014000 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 568707014001 acyl-CoA synthetase; Validated; Region: PRK06164 568707014002 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707014003 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707014004 AMP binding site [chemical binding]; other site 568707014005 active site 568707014006 acyl-activating enzyme (AAE) consensus motif; other site 568707014007 CoA binding site [chemical binding]; other site 568707014008 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707014009 short chain dehydrogenase; Provisional; Region: PRK07577 568707014010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707014011 NAD(P) binding site [chemical binding]; other site 568707014012 active site 568707014013 hypothetical protein; Provisional; Region: PRK07546 568707014014 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 568707014015 substrate-cofactor binding pocket; other site 568707014016 aminodeoxychorismate synthase; Provisional; Region: PRK07508 568707014017 chorismate binding enzyme; Region: Chorismate_bind; cl10555 568707014018 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 568707014019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707014020 Walker A/P-loop; other site 568707014021 ATP binding site [chemical binding]; other site 568707014022 Q-loop/lid; other site 568707014023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707014024 ABC transporter signature motif; other site 568707014025 Walker B; other site 568707014026 D-loop; other site 568707014027 H-loop/switch region; other site 568707014028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707014029 Walker A/P-loop; other site 568707014030 ATP binding site [chemical binding]; other site 568707014031 Q-loop/lid; other site 568707014032 ABC transporter signature motif; other site 568707014033 Walker B; other site 568707014034 D-loop; other site 568707014035 H-loop/switch region; other site 568707014036 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568707014037 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 568707014038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707014039 Walker A/P-loop; other site 568707014040 ATP binding site [chemical binding]; other site 568707014041 Q-loop/lid; other site 568707014042 ABC transporter signature motif; other site 568707014043 Walker B; other site 568707014044 D-loop; other site 568707014045 H-loop/switch region; other site 568707014046 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707014047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707014048 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568707014049 putative effector binding pocket; other site 568707014050 dimerization interface [polypeptide binding]; other site 568707014051 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568707014052 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568707014053 active site 568707014054 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 568707014055 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 568707014056 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568707014057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707014058 dimer interface [polypeptide binding]; other site 568707014059 conserved gate region; other site 568707014060 putative PBP binding loops; other site 568707014061 ABC-ATPase subunit interface; other site 568707014062 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568707014063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707014064 dimer interface [polypeptide binding]; other site 568707014065 conserved gate region; other site 568707014066 putative PBP binding loops; other site 568707014067 ABC-ATPase subunit interface; other site 568707014068 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568707014069 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707014070 Walker A/P-loop; other site 568707014071 ATP binding site [chemical binding]; other site 568707014072 Q-loop/lid; other site 568707014073 ABC transporter signature motif; other site 568707014074 Walker B; other site 568707014075 D-loop; other site 568707014076 H-loop/switch region; other site 568707014077 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568707014078 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 568707014079 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707014080 Walker A/P-loop; other site 568707014081 ATP binding site [chemical binding]; other site 568707014082 Q-loop/lid; other site 568707014083 ABC transporter signature motif; other site 568707014084 Walker B; other site 568707014085 D-loop; other site 568707014086 H-loop/switch region; other site 568707014087 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 568707014088 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 568707014089 dimer interface [polypeptide binding]; other site 568707014090 indole acetimide hydrolase; Validated; Region: PRK07488 568707014091 Amidase; Region: Amidase; cl11426 568707014092 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 568707014093 EamA-like transporter family; Region: EamA; pfam00892 568707014094 EamA-like transporter family; Region: EamA; pfam00892 568707014095 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 568707014096 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568707014097 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568707014098 ABC transporter; Region: ABC_tran_2; pfam12848 568707014099 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 568707014100 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 568707014101 Isochorismatase family; Region: Isochorismatase; pfam00857 568707014102 catalytic triad [active] 568707014103 conserved cis-peptide bond; other site 568707014104 cell division topological specificity factor MinE; Provisional; Region: PRK13989 568707014105 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 568707014106 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 568707014107 Switch I; other site 568707014108 Switch II; other site 568707014109 septum formation inhibitor; Provisional; Region: minC; PRK00030 568707014110 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 568707014111 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 568707014112 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 568707014113 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568707014114 active site 568707014115 HIGH motif; other site 568707014116 nucleotide binding site [chemical binding]; other site 568707014117 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 568707014118 KMSKS motif; other site 568707014119 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 568707014120 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 568707014121 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 568707014122 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 568707014123 sensor protein RstB; Provisional; Region: PRK10604 568707014124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707014125 ATP binding site [chemical binding]; other site 568707014126 Mg2+ binding site [ion binding]; other site 568707014127 G-X-G motif; other site 568707014128 osmolarity response regulator; Provisional; Region: ompR; PRK09468 568707014129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707014130 active site 568707014131 phosphorylation site [posttranslational modification] 568707014132 intermolecular recognition site; other site 568707014133 dimerization interface [polypeptide binding]; other site 568707014134 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707014135 DNA binding site [nucleotide binding] 568707014136 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 568707014137 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 568707014138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568707014139 ATP binding site [chemical binding]; other site 568707014140 putative Mg++ binding site [ion binding]; other site 568707014141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568707014142 nucleotide binding region [chemical binding]; other site 568707014143 ATP-binding site [chemical binding]; other site 568707014144 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 568707014145 HRDC domain; Region: HRDC; pfam00570 568707014146 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 568707014147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707014148 Walker A motif; other site 568707014149 ATP binding site [chemical binding]; other site 568707014150 Walker B motif; other site 568707014151 arginine finger; other site 568707014152 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 568707014153 serine racemase; Region: PLN02970 568707014154 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 568707014155 tetramer interface [polypeptide binding]; other site 568707014156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707014157 catalytic residue [active] 568707014158 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 568707014159 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 568707014160 putative NAD(P) binding site [chemical binding]; other site 568707014161 active site 568707014162 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 568707014163 RuvA N terminal domain; Region: RuvA_N; pfam01330 568707014164 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 568707014165 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 568707014166 active site 568707014167 putative DNA-binding cleft [nucleotide binding]; other site 568707014168 dimer interface [polypeptide binding]; other site 568707014169 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 568707014170 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 568707014171 purine monophosphate binding site [chemical binding]; other site 568707014172 dimer interface [polypeptide binding]; other site 568707014173 putative catalytic residues [active] 568707014174 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 568707014175 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 568707014176 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 568707014177 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 568707014178 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 568707014179 FMN binding site [chemical binding]; other site 568707014180 active site 568707014181 catalytic residues [active] 568707014182 substrate binding site [chemical binding]; other site 568707014183 hypothetical protein; Provisional; Region: PRK06996 568707014184 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 568707014185 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 568707014186 proline aminopeptidase P II; Provisional; Region: PRK10879 568707014187 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 568707014188 active site 568707014189 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 568707014190 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568707014191 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 568707014192 trimer interface [polypeptide binding]; other site 568707014193 eyelet of channel; other site 568707014194 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 568707014195 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 568707014196 active site 568707014197 tetramer interface; other site 568707014198 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 568707014199 Peptidase family M48; Region: Peptidase_M48; cl12018 568707014200 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 568707014201 SnoaL-like domain; Region: SnoaL_3; pfam13474 568707014202 SnoaL-like domain; Region: SnoaL_2; pfam12680 568707014203 Zinc-finger domain; Region: zf-CHCC; cl01821 568707014204 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 568707014205 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 568707014206 homodimer interface [polypeptide binding]; other site 568707014207 substrate-cofactor binding pocket; other site 568707014208 catalytic residue [active] 568707014209 AzlC protein; Region: AzlC; pfam03591 568707014210 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 568707014211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 568707014212 putative Mg++ binding site [ion binding]; other site 568707014213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568707014214 nucleotide binding region [chemical binding]; other site 568707014215 ATP-binding site [chemical binding]; other site 568707014216 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568707014217 catalytic residues [active] 568707014218 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 568707014219 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 568707014220 competence damage-inducible protein A; Provisional; Region: PRK01215 568707014221 putative MPT binding site; other site 568707014222 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707014223 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707014224 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707014225 Rho-activating domain of cytotoxic necrotizing factor; Region: CNF1; pfam05785 568707014226 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707014227 Phasin protein; Region: Phasin_2; pfam09361 568707014228 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 568707014229 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 568707014230 quinone interaction residues [chemical binding]; other site 568707014231 active site 568707014232 catalytic residues [active] 568707014233 FMN binding site [chemical binding]; other site 568707014234 substrate binding site [chemical binding]; other site 568707014235 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 568707014236 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 568707014237 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 568707014238 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 568707014239 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 568707014240 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 568707014241 nudix motif; other site 568707014242 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707014243 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707014244 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 568707014245 putative effector binding pocket; other site 568707014246 dimerization interface [polypeptide binding]; other site 568707014247 DoxX; Region: DoxX; pfam07681 568707014248 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 568707014249 LysE type translocator; Region: LysE; cl00565 568707014250 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 568707014251 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 568707014252 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707014253 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 568707014254 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 568707014255 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 568707014256 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 568707014257 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568707014258 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 568707014259 DNA binding residues [nucleotide binding] 568707014260 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 568707014261 dimer interface [polypeptide binding]; other site 568707014262 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 568707014263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568707014264 non-specific DNA binding site [nucleotide binding]; other site 568707014265 salt bridge; other site 568707014266 sequence-specific DNA binding site [nucleotide binding]; other site 568707014267 Cupin domain; Region: Cupin_2; pfam07883 568707014268 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568707014269 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568707014270 extended (e) SDRs; Region: SDR_e; cd08946 568707014271 NAD(P) binding site [chemical binding]; other site 568707014272 active site 568707014273 substrate binding site [chemical binding]; other site 568707014274 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 568707014275 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568707014276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707014277 DNA-binding site [nucleotide binding]; DNA binding site 568707014278 FCD domain; Region: FCD; pfam07729 568707014280 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 568707014281 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 568707014282 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 568707014283 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 568707014284 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568707014285 active site 568707014286 catalytic tetrad [active] 568707014287 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707014288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707014289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707014290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707014291 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 568707014292 putative dimerization interface [polypeptide binding]; other site 568707014294 enoyl-CoA hydratase; Provisional; Region: PRK06688 568707014295 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 568707014296 substrate binding site [chemical binding]; other site 568707014297 oxyanion hole (OAH) forming residues; other site 568707014298 trimer interface [polypeptide binding]; other site 568707014299 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 568707014300 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 568707014301 putative active site [active] 568707014302 putative catalytic site [active] 568707014303 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 568707014304 CoA-transferase family III; Region: CoA_transf_3; pfam02515 568707014305 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707014306 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 568707014307 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 568707014308 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 568707014309 homodimer interface [polypeptide binding]; other site 568707014310 NADP binding site [chemical binding]; other site 568707014311 substrate binding site [chemical binding]; other site 568707014312 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 568707014313 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707014314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707014315 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568707014316 dimerization interface [polypeptide binding]; other site 568707014317 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 568707014318 active site 568707014319 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 568707014320 dimer interface [polypeptide binding]; other site 568707014321 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 568707014322 hydroxyglutarate oxidase; Provisional; Region: PRK11728 568707014323 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 568707014324 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 568707014325 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 568707014326 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 568707014327 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 568707014328 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 568707014329 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 568707014330 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 568707014331 putative active site [active] 568707014332 putative substrate binding site [chemical binding]; other site 568707014333 putative cosubstrate binding site; other site 568707014334 catalytic site [active] 568707014335 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707014336 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 568707014337 pyrimidine utilization protein D; Region: RutD; TIGR03611 568707014338 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 568707014339 FAD binding domain; Region: FAD_binding_4; pfam01565 568707014340 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 568707014341 dihydrodipicolinate reductase; Provisional; Region: PRK00048 568707014342 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 568707014343 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 568707014344 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 568707014345 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 568707014346 ferric uptake regulator; Provisional; Region: fur; PRK09462 568707014347 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568707014348 metal binding site 2 [ion binding]; metal-binding site 568707014349 putative DNA binding helix; other site 568707014350 metal binding site 1 [ion binding]; metal-binding site 568707014351 dimer interface [polypeptide binding]; other site 568707014352 structural Zn2+ binding site [ion binding]; other site 568707014353 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 568707014354 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 568707014355 Walker A/P-loop; other site 568707014356 ATP binding site [chemical binding]; other site 568707014357 Q-loop/lid; other site 568707014358 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 568707014359 ABC transporter signature motif; other site 568707014360 Walker B; other site 568707014361 D-loop; other site 568707014362 H-loop/switch region; other site 568707014363 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 568707014364 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 568707014365 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 568707014366 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 568707014367 ferrochelatase; Reviewed; Region: hemH; PRK00035 568707014368 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 568707014369 C-terminal domain interface [polypeptide binding]; other site 568707014370 active site 568707014371 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 568707014372 active site 568707014373 N-terminal domain interface [polypeptide binding]; other site 568707014374 GrpE; Region: GrpE; pfam01025 568707014375 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 568707014376 dimer interface [polypeptide binding]; other site 568707014377 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 568707014378 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568707014379 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 568707014380 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 568707014381 nucleotide binding site [chemical binding]; other site 568707014382 NEF interaction site [polypeptide binding]; other site 568707014383 SBD interface [polypeptide binding]; other site 568707014384 chaperone protein DnaJ; Provisional; Region: PRK10767 568707014385 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 568707014386 HSP70 interaction site [polypeptide binding]; other site 568707014387 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 568707014388 Zn binding sites [ion binding]; other site 568707014389 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 568707014390 dimer interface [polypeptide binding]; other site 568707014391 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 568707014392 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 568707014393 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568707014394 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 568707014395 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568707014396 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 568707014397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 568707014398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 568707014399 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568707014400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707014401 Walker A motif; other site 568707014402 ATP binding site [chemical binding]; other site 568707014403 Walker B motif; other site 568707014404 arginine finger; other site 568707014405 Cytochrome c553 [Energy production and conversion]; Region: COG2863 568707014406 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 568707014407 Cytochrome c553 [Energy production and conversion]; Region: COG2863 568707014408 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 568707014409 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 568707014410 isocitrate dehydrogenase; Validated; Region: PRK07362 568707014411 isocitrate dehydrogenase; Reviewed; Region: PRK07006 568707014412 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 568707014413 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568707014414 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 568707014415 O-Antigen ligase; Region: Wzy_C; pfam04932 568707014416 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 568707014417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707014418 active site 568707014419 phosphorylation site [posttranslational modification] 568707014420 intermolecular recognition site; other site 568707014421 dimerization interface [polypeptide binding]; other site 568707014422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707014423 DNA binding site [nucleotide binding] 568707014424 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 568707014425 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 568707014426 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 568707014427 Ligand Binding Site [chemical binding]; other site 568707014428 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 568707014429 GAF domain; Region: GAF_3; pfam13492 568707014430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707014431 dimer interface [polypeptide binding]; other site 568707014432 phosphorylation site [posttranslational modification] 568707014433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707014434 ATP binding site [chemical binding]; other site 568707014435 Mg2+ binding site [ion binding]; other site 568707014436 G-X-G motif; other site 568707014437 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 568707014438 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 568707014439 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568707014440 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 568707014441 putative solute:sodium symporter small subunit; Region: Na_symport_sm; TIGR03647 568707014442 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 568707014443 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 568707014444 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 568707014445 Smr domain; Region: Smr; pfam01713 568707014446 thioredoxin reductase; Provisional; Region: PRK10262 568707014447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568707014448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707014449 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 568707014450 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 568707014451 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 568707014452 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 568707014453 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 568707014454 recombination factor protein RarA; Reviewed; Region: PRK13342 568707014455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 568707014456 Walker A motif; other site 568707014457 ATP binding site [chemical binding]; other site 568707014458 Walker B motif; other site 568707014459 arginine finger; other site 568707014460 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 568707014461 seryl-tRNA synthetase; Provisional; Region: PRK05431 568707014462 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 568707014463 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 568707014464 dimer interface [polypeptide binding]; other site 568707014465 active site 568707014466 motif 1; other site 568707014467 motif 2; other site 568707014468 motif 3; other site 568707014469 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707014470 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707014471 metal binding site [ion binding]; metal-binding site 568707014472 active site 568707014473 I-site; other site 568707014474 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 568707014475 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 568707014476 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707014477 N-terminal plug; other site 568707014478 ligand-binding site [chemical binding]; other site 568707014479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707014480 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 568707014481 putative substrate translocation pore; other site 568707014482 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568707014483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707014485 siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950 568707014486 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 568707014487 IucA / IucC family; Region: IucA_IucC; pfam04183 568707014488 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 568707014489 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 568707014490 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 568707014491 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 568707014492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 568707014493 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 568707014494 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 568707014495 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 568707014496 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 568707014497 NAD binding site [chemical binding]; other site 568707014498 homotetramer interface [polypeptide binding]; other site 568707014499 homodimer interface [polypeptide binding]; other site 568707014500 substrate binding site [chemical binding]; other site 568707014501 active site 568707014502 hypothetical protein; Validated; Region: PRK02101 568707014503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707014504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568707014505 putative substrate translocation pore; other site 568707014506 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 568707014507 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 568707014508 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 568707014509 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707014510 PYR/PP interface [polypeptide binding]; other site 568707014511 dimer interface [polypeptide binding]; other site 568707014512 TPP binding site [chemical binding]; other site 568707014513 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707014514 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 568707014515 TPP-binding site [chemical binding]; other site 568707014516 dimer interface [polypeptide binding]; other site 568707014517 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 568707014518 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 568707014519 putative valine binding site [chemical binding]; other site 568707014520 dimer interface [polypeptide binding]; other site 568707014521 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 568707014522 ketol-acid reductoisomerase; Provisional; Region: PRK05479 568707014523 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 568707014524 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 568707014525 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 568707014526 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 568707014527 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 568707014528 16S/18S rRNA binding site [nucleotide binding]; other site 568707014529 S13e-L30e interaction site [polypeptide binding]; other site 568707014530 25S rRNA binding site [nucleotide binding]; other site 568707014531 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 568707014532 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 568707014533 RNase E interface [polypeptide binding]; other site 568707014534 trimer interface [polypeptide binding]; other site 568707014535 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 568707014536 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 568707014537 RNase E interface [polypeptide binding]; other site 568707014538 trimer interface [polypeptide binding]; other site 568707014539 active site 568707014540 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 568707014541 putative nucleic acid binding region [nucleotide binding]; other site 568707014542 G-X-X-G motif; other site 568707014543 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 568707014544 RNA binding site [nucleotide binding]; other site 568707014545 domain interface; other site 568707014546 threonine dehydratase; Provisional; Region: PRK07334 568707014547 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 568707014548 tetramer interface [polypeptide binding]; other site 568707014549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707014550 catalytic residue [active] 568707014551 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 568707014552 PIN domain; Region: PIN_3; pfam13470 568707014553 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 568707014554 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 568707014555 NAD(P) binding site [chemical binding]; other site 568707014556 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 568707014557 triosephosphate isomerase; Provisional; Region: PRK14567 568707014558 substrate binding site [chemical binding]; other site 568707014559 dimer interface [polypeptide binding]; other site 568707014560 catalytic triad [active] 568707014561 Preprotein translocase SecG subunit; Region: SecG; cl09123 568707014562 BCCT family transporter; Region: BCCT; cl00569 568707014563 Transcriptional regulator [Transcription]; Region: IclR; COG1414 568707014564 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 568707014565 Bacterial transcriptional regulator; Region: IclR; pfam01614 568707014566 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 568707014567 dimer interface [polypeptide binding]; other site 568707014568 Methylaspartate ammonia-lyase C-terminus; Region: MAAL_C; pfam07476 568707014569 active site 568707014570 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707014571 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 568707014572 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 568707014573 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 568707014574 active sites [active] 568707014575 tetramer interface [polypeptide binding]; other site 568707014576 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707014577 short chain dehydrogenase; Provisional; Region: PRK08339 568707014578 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 568707014579 putative NAD(P) binding site [chemical binding]; other site 568707014580 putative active site [active] 568707014581 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 568707014582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707014583 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 568707014584 putative dimerization interface [polypeptide binding]; other site 568707014585 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 568707014586 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568707014587 homodimer interface [polypeptide binding]; other site 568707014588 substrate-cofactor binding pocket; other site 568707014589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707014590 catalytic residue [active] 568707014591 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 568707014592 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 568707014593 active site 568707014594 Zn binding site [ion binding]; other site 568707014595 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707014596 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568707014597 active site residue [active] 568707014598 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 568707014599 active site residue [active] 568707014600 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 568707014601 active site residue [active] 568707014602 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 568707014603 active site residue [active] 568707014604 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707014605 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 568707014606 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 568707014607 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 568707014608 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 568707014609 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 568707014610 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 568707014611 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 568707014612 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 568707014613 azurin; Region: azurin; TIGR02695 568707014614 Predicted transcriptional regulator [Transcription]; Region: COG2345 568707014615 Transcriptional regulator PadR-like family; Region: PadR; cl17335 568707014616 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 568707014617 multidrug efflux protein; Reviewed; Region: PRK09579 568707014618 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568707014619 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 568707014620 HlyD family secretion protein; Region: HlyD_3; pfam13437 568707014621 Predicted transcriptional regulators [Transcription]; Region: COG1733 568707014622 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 568707014623 BCCT family transporter; Region: BCCT; cl00569 568707014624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707014625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707014626 LysR substrate binding domain; Region: LysR_substrate; pfam03466 568707014627 dimerization interface [polypeptide binding]; other site 568707014628 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 568707014629 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 568707014630 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568707014631 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568707014632 active site 568707014633 metal binding site [ion binding]; metal-binding site 568707014634 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 568707014635 active site 568707014636 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 568707014637 CoenzymeA binding site [chemical binding]; other site 568707014638 subunit interaction site [polypeptide binding]; other site 568707014639 PHB binding site; other site 568707014640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568707014641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568707014642 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 568707014643 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 568707014644 trimer interface [polypeptide binding]; other site 568707014645 eyelet of channel; other site 568707014646 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 568707014647 NADH dehydrogenase subunit B; Validated; Region: PRK06411 568707014648 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 568707014649 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 568707014650 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 568707014651 NADH dehydrogenase subunit D; Validated; Region: PRK06075 568707014652 NADH dehydrogenase subunit E; Validated; Region: PRK07539 568707014653 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 568707014654 putative dimer interface [polypeptide binding]; other site 568707014655 [2Fe-2S] cluster binding site [ion binding]; other site 568707014656 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 568707014657 SLBB domain; Region: SLBB; pfam10531 568707014658 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 568707014659 NADH dehydrogenase subunit G; Validated; Region: PRK09129 568707014660 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 568707014661 catalytic loop [active] 568707014662 iron binding site [ion binding]; other site 568707014663 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 568707014664 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 568707014665 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 568707014666 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 568707014667 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 568707014668 4Fe-4S binding domain; Region: Fer4; pfam00037 568707014669 4Fe-4S binding domain; Region: Fer4; cl02805 568707014670 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 568707014671 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 568707014672 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 568707014673 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 568707014674 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568707014675 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 568707014676 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568707014677 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 568707014678 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 568707014679 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 568707014680 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 568707014681 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707014682 N-terminal plug; other site 568707014683 ligand-binding site [chemical binding]; other site 568707014684 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 568707014685 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707014686 N-terminal plug; other site 568707014687 ligand-binding site [chemical binding]; other site 568707014688 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 568707014689 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 568707014690 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 568707014691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707014692 NAD(P) binding site [chemical binding]; other site 568707014693 active site 568707014694 acetolactate synthase catalytic subunit; Validated; Region: PRK06112 568707014695 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707014696 PYR/PP interface [polypeptide binding]; other site 568707014697 dimer interface [polypeptide binding]; other site 568707014698 TPP binding site [chemical binding]; other site 568707014699 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568707014700 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 568707014701 TPP-binding site [chemical binding]; other site 568707014702 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707014703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707014704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707014705 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 568707014706 putative dimerization interface [polypeptide binding]; other site 568707014707 phosphoserine phosphatase SerB; Region: serB; TIGR00338 568707014708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707014709 motif II; other site 568707014710 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 568707014711 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 568707014712 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568707014713 ATP binding site [chemical binding]; other site 568707014714 putative Mg++ binding site [ion binding]; other site 568707014715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568707014716 nucleotide binding region [chemical binding]; other site 568707014717 ATP-binding site [chemical binding]; other site 568707014718 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 568707014719 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 568707014720 substrate binding site; other site 568707014721 dimer interface; other site 568707014722 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 568707014723 homotrimer interaction site [polypeptide binding]; other site 568707014724 zinc binding site [ion binding]; other site 568707014725 CDP-binding sites; other site 568707014726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707014727 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 568707014728 Helix-turn-helix domain; Region: HTH_18; pfam12833 568707014729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568707014730 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 568707014731 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 568707014732 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 568707014733 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 568707014734 dimer interface [polypeptide binding]; other site 568707014735 decamer (pentamer of dimers) interface [polypeptide binding]; other site 568707014736 catalytic triad [active] 568707014737 peroxidatic and resolving cysteines [active] 568707014738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 568707014739 dimerization interface [polypeptide binding]; other site 568707014740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 568707014741 dimer interface [polypeptide binding]; other site 568707014742 phosphorylation site [posttranslational modification] 568707014743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568707014744 ATP binding site [chemical binding]; other site 568707014745 Mg2+ binding site [ion binding]; other site 568707014746 G-X-G motif; other site 568707014747 osmolarity response regulator; Provisional; Region: ompR; PRK09468 568707014748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 568707014749 active site 568707014750 phosphorylation site [posttranslational modification] 568707014751 intermolecular recognition site; other site 568707014752 dimerization interface [polypeptide binding]; other site 568707014753 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 568707014754 DNA binding site [nucleotide binding] 568707014755 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 568707014756 Glycoprotease family; Region: Peptidase_M22; pfam00814 568707014757 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 568707014758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568707014759 Coenzyme A binding pocket [chemical binding]; other site 568707014760 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 568707014761 Fe-S cluster binding site [ion binding]; other site 568707014762 active site 568707014763 lysophospholipid transporter LplT; Provisional; Region: PRK11195 568707014764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707014765 putative substrate translocation pore; other site 568707014766 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 568707014767 AAA domain; Region: AAA_23; pfam13476 568707014768 Walker A/P-loop; other site 568707014769 ATP binding site [chemical binding]; other site 568707014770 Q-loop/lid; other site 568707014771 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 568707014772 ABC transporter signature motif; other site 568707014773 Walker B; other site 568707014774 D-loop; other site 568707014775 H-loop/switch region; other site 568707014776 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 568707014777 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 568707014778 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 568707014779 nucleotide binding pocket [chemical binding]; other site 568707014780 K-X-D-G motif; other site 568707014781 catalytic site [active] 568707014782 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 568707014783 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 568707014784 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 568707014785 Dimer interface [polypeptide binding]; other site 568707014786 BRCT sequence motif; other site 568707014787 SurA N-terminal domain; Region: SurA_N_3; cl07813 568707014788 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 568707014789 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 568707014790 BolA-like protein; Region: BolA; pfam01722 568707014791 intracellular septation protein A; Reviewed; Region: PRK00259 568707014792 methionine sulfoxide reductase B; Provisional; Region: PRK00222 568707014793 SelR domain; Region: SelR; pfam01641 568707014794 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568707014795 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 568707014796 Walker A/P-loop; other site 568707014797 ATP binding site [chemical binding]; other site 568707014798 Q-loop/lid; other site 568707014799 ABC transporter signature motif; other site 568707014800 Walker B; other site 568707014801 D-loop; other site 568707014802 H-loop/switch region; other site 568707014803 Cobalt transport protein; Region: CbiQ; cl00463 568707014804 BioY family; Region: BioY; pfam02632 568707014805 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568707014806 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 568707014807 putative ligand binding site [chemical binding]; other site 568707014808 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707014809 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707014810 TM-ABC transporter signature motif; other site 568707014811 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707014812 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707014813 TM-ABC transporter signature motif; other site 568707014814 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707014815 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707014816 Walker A/P-loop; other site 568707014817 ATP binding site [chemical binding]; other site 568707014818 Q-loop/lid; other site 568707014819 ABC transporter signature motif; other site 568707014820 Walker B; other site 568707014821 D-loop; other site 568707014822 H-loop/switch region; other site 568707014823 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707014824 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707014825 Walker A/P-loop; other site 568707014826 ATP binding site [chemical binding]; other site 568707014827 Q-loop/lid; other site 568707014828 ABC transporter signature motif; other site 568707014829 Walker B; other site 568707014830 D-loop; other site 568707014831 H-loop/switch region; other site 568707014832 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 568707014833 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 568707014834 homodimer interface [polypeptide binding]; other site 568707014835 substrate-cofactor binding pocket; other site 568707014836 catalytic residue [active] 568707014837 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 568707014838 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568707014839 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 568707014840 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568707014841 TM-ABC transporter signature motif; other site 568707014842 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568707014843 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 568707014844 TM-ABC transporter signature motif; other site 568707014845 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707014846 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 568707014847 putative ligand binding site [chemical binding]; other site 568707014848 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568707014849 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 568707014850 Walker A/P-loop; other site 568707014851 ATP binding site [chemical binding]; other site 568707014852 Q-loop/lid; other site 568707014853 ABC transporter signature motif; other site 568707014854 Walker B; other site 568707014855 D-loop; other site 568707014856 H-loop/switch region; other site 568707014857 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568707014858 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 568707014859 Walker A/P-loop; other site 568707014860 ATP binding site [chemical binding]; other site 568707014861 Q-loop/lid; other site 568707014862 ABC transporter signature motif; other site 568707014863 Walker B; other site 568707014864 D-loop; other site 568707014865 H-loop/switch region; other site 568707014866 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 568707014867 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568707014868 minor groove reading motif; other site 568707014869 helix-hairpin-helix signature motif; other site 568707014870 substrate binding pocket [chemical binding]; other site 568707014871 active site 568707014872 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 568707014873 ferredoxin; Provisional; Region: PRK08764 568707014874 Putative Fe-S cluster; Region: FeS; cl17515 568707014875 4Fe-4S binding domain; Region: Fer4; cl02805 568707014876 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 568707014877 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 568707014878 ferredoxin-NADP reductase; Provisional; Region: PRK10926 568707014879 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 568707014880 FAD binding pocket [chemical binding]; other site 568707014881 FAD binding motif [chemical binding]; other site 568707014882 phosphate binding motif [ion binding]; other site 568707014883 beta-alpha-beta structure motif; other site 568707014884 NAD binding pocket [chemical binding]; other site 568707014885 Ferredoxin [Energy production and conversion]; Region: COG1146 568707014886 4Fe-4S binding domain; Region: Fer4; pfam00037 568707014887 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 568707014888 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 568707014889 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 568707014890 active site 568707014891 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 568707014892 homotrimer interaction site [polypeptide binding]; other site 568707014893 putative active site [active] 568707014894 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 568707014895 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 568707014896 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 568707014897 HD domain; Region: HD_4; pfam13328 568707014898 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 568707014899 synthetase active site [active] 568707014900 NTP binding site [chemical binding]; other site 568707014901 metal binding site [ion binding]; metal-binding site 568707014902 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 568707014903 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 568707014904 acetylornithine deacetylase; Provisional; Region: PRK07522 568707014905 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 568707014906 metal binding site [ion binding]; metal-binding site 568707014907 putative dimer interface [polypeptide binding]; other site 568707014908 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 568707014909 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 568707014910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707014911 catalytic residue [active] 568707014912 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 568707014913 substrate binding site [chemical binding]; other site 568707014914 active site 568707014915 catalytic residues [active] 568707014916 heterodimer interface [polypeptide binding]; other site 568707014917 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 568707014918 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 568707014919 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 568707014920 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 568707014921 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 568707014922 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 568707014923 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 568707014924 homodimer interface [polypeptide binding]; other site 568707014925 oligonucleotide binding site [chemical binding]; other site 568707014926 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 568707014927 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568707014928 RNA binding surface [nucleotide binding]; other site 568707014929 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568707014930 active site 568707014931 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 568707014932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 568707014933 motif II; other site 568707014934 TMAO/DMSO reductase; Reviewed; Region: PRK05363 568707014935 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 568707014936 Moco binding site; other site 568707014937 metal coordination site [ion binding]; other site 568707014938 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 568707014939 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 568707014940 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 568707014941 amidase catalytic site [active] 568707014942 Zn binding residues [ion binding]; other site 568707014943 substrate binding site [chemical binding]; other site 568707014944 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568707014945 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 568707014946 putative SAM binding site [chemical binding]; other site 568707014947 homodimer interface [polypeptide binding]; other site 568707014948 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 568707014949 active site 568707014950 dimer interface [polypeptide binding]; other site 568707014951 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 568707014952 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 568707014953 putative phosphate acyltransferase; Provisional; Region: PRK05331 568707014954 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 568707014955 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 568707014956 dimer interface [polypeptide binding]; other site 568707014957 active site 568707014958 CoA binding pocket [chemical binding]; other site 568707014959 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 568707014960 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 568707014961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707014962 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 568707014963 NAD(P) binding site [chemical binding]; other site 568707014964 active site 568707014965 acyl carrier protein; Provisional; Region: acpP; PRK00982 568707014966 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 568707014967 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 568707014968 dimer interface [polypeptide binding]; other site 568707014969 active site 568707014970 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 568707014971 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707014972 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568707014973 DNA binding residues [nucleotide binding] 568707014974 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 568707014975 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 568707014976 anti-sigma E factor; Provisional; Region: rseB; PRK09455 568707014977 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 568707014978 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 568707014979 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568707014980 protein binding site [polypeptide binding]; other site 568707014981 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 568707014982 GTP-binding protein LepA; Provisional; Region: PRK05433 568707014983 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 568707014984 G1 box; other site 568707014985 putative GEF interaction site [polypeptide binding]; other site 568707014986 GTP/Mg2+ binding site [chemical binding]; other site 568707014987 Switch I region; other site 568707014988 G2 box; other site 568707014989 G3 box; other site 568707014990 Switch II region; other site 568707014991 G4 box; other site 568707014992 G5 box; other site 568707014993 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 568707014994 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 568707014995 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 568707014996 signal peptidase I; Provisional; Region: PRK10861 568707014997 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568707014998 Catalytic site [active] 568707014999 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568707015000 ribonuclease III; Reviewed; Region: rnc; PRK00102 568707015001 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 568707015002 dimerization interface [polypeptide binding]; other site 568707015003 active site 568707015004 metal binding site [ion binding]; metal-binding site 568707015005 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 568707015006 GTPase Era; Reviewed; Region: era; PRK00089 568707015007 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 568707015008 G1 box; other site 568707015009 GTP/Mg2+ binding site [chemical binding]; other site 568707015010 Switch I region; other site 568707015011 G2 box; other site 568707015012 Switch II region; other site 568707015013 G3 box; other site 568707015014 G4 box; other site 568707015015 G5 box; other site 568707015016 KH domain; Region: KH_2; pfam07650 568707015017 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 568707015018 Recombination protein O N terminal; Region: RecO_N; pfam11967 568707015019 Recombination protein O C terminal; Region: RecO_C; pfam02565 568707015020 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 568707015021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707015022 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707015023 dimerization interface [polypeptide binding]; other site 568707015024 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 568707015025 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 568707015026 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568707015027 catalytic residue [active] 568707015028 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 568707015029 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 568707015030 putative active site [active] 568707015031 Zn binding site [ion binding]; other site 568707015033 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 568707015034 YccA-like proteins; Region: YccA_like; cd10433 568707015035 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 568707015036 multifunctional aminopeptidase A; Provisional; Region: PRK00913 568707015037 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 568707015038 interface (dimer of trimers) [polypeptide binding]; other site 568707015039 Substrate-binding/catalytic site; other site 568707015040 Zn-binding sites [ion binding]; other site 568707015041 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 568707015042 Predicted permeases [General function prediction only]; Region: COG0795 568707015043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707015044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707015045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707015046 dimerization interface [polypeptide binding]; other site 568707015047 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 568707015048 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 568707015049 putative ligand binding site [chemical binding]; other site 568707015050 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 568707015051 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 568707015052 tetrameric interface [polypeptide binding]; other site 568707015053 NAD binding site [chemical binding]; other site 568707015054 catalytic residues [active] 568707015055 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 568707015056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707015057 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 568707015058 substrate binding site [chemical binding]; other site 568707015059 dimerization interface [polypeptide binding]; other site 568707015060 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 568707015061 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 568707015062 NlpC/P60 family; Region: NLPC_P60; pfam00877 568707015063 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 568707015064 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707015065 acyl-activating enzyme (AAE) consensus motif; other site 568707015066 AMP binding site [chemical binding]; other site 568707015067 active site 568707015068 CoA binding site [chemical binding]; other site 568707015069 Domain of unknown function (DUF336); Region: DUF336; cl01249 568707015070 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 568707015071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707015072 putative substrate translocation pore; other site 568707015073 acetyl-CoA synthetase; Provisional; Region: PRK00174 568707015074 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 568707015075 active site 568707015076 CoA binding site [chemical binding]; other site 568707015077 acyl-activating enzyme (AAE) consensus motif; other site 568707015078 AMP binding site [chemical binding]; other site 568707015079 acetate binding site [chemical binding]; other site 568707015080 EamA-like transporter family; Region: EamA; pfam00892 568707015081 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 568707015082 EamA-like transporter family; Region: EamA; pfam00892 568707015083 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 568707015084 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 568707015085 tetramer interface [polypeptide binding]; other site 568707015086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707015087 catalytic residue [active] 568707015088 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 568707015089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707015090 NAD(P) binding site [chemical binding]; other site 568707015091 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 568707015092 active site 568707015093 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 568707015094 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 568707015095 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 568707015096 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 568707015097 active site 568707015098 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 568707015099 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 568707015100 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568707015101 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568707015102 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 568707015103 putative active site [active] 568707015104 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 568707015105 catalytic nucleophile [active] 568707015106 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 568707015107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707015108 Walker A/P-loop; other site 568707015109 ATP binding site [chemical binding]; other site 568707015110 Q-loop/lid; other site 568707015111 ABC transporter signature motif; other site 568707015112 Walker B; other site 568707015113 D-loop; other site 568707015114 H-loop/switch region; other site 568707015115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568707015116 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 568707015117 Walker A/P-loop; other site 568707015118 ATP binding site [chemical binding]; other site 568707015119 Q-loop/lid; other site 568707015120 ABC transporter signature motif; other site 568707015121 Walker B; other site 568707015122 D-loop; other site 568707015123 H-loop/switch region; other site 568707015124 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 568707015125 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 568707015126 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 568707015127 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 568707015128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707015129 dimer interface [polypeptide binding]; other site 568707015130 conserved gate region; other site 568707015131 putative PBP binding loops; other site 568707015132 ABC-ATPase subunit interface; other site 568707015133 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 568707015134 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568707015135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707015136 dimer interface [polypeptide binding]; other site 568707015137 conserved gate region; other site 568707015138 putative PBP binding loops; other site 568707015139 ABC-ATPase subunit interface; other site 568707015140 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 568707015141 homodimer interface [polypeptide binding]; other site 568707015142 homotetramer interface [polypeptide binding]; other site 568707015143 active site pocket [active] 568707015144 cleavage site 568707015145 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 568707015146 SxDxEG motif; other site 568707015147 active site 568707015148 metal binding site [ion binding]; metal-binding site 568707015149 homopentamer interface [polypeptide binding]; other site 568707015150 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568707015151 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568707015152 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568707015153 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 568707015154 active site 568707015155 CTP synthetase; Validated; Region: pyrG; PRK05380 568707015156 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 568707015157 Catalytic site [active] 568707015158 active site 568707015159 UTP binding site [chemical binding]; other site 568707015160 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 568707015161 active site 568707015162 putative oxyanion hole; other site 568707015163 catalytic triad [active] 568707015164 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 568707015165 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 568707015166 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 568707015167 enolase; Provisional; Region: eno; PRK00077 568707015168 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 568707015169 dimer interface [polypeptide binding]; other site 568707015170 metal binding site [ion binding]; metal-binding site 568707015171 substrate binding pocket [chemical binding]; other site 568707015172 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 568707015173 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 568707015174 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 568707015175 DNA binding site [nucleotide binding] 568707015176 Predicted integral membrane protein [Function unknown]; Region: COG5616 568707015177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707015178 NADH(P)-binding; Region: NAD_binding_10; pfam13460 568707015179 NAD(P) binding site [chemical binding]; other site 568707015180 active site 568707015181 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 568707015182 Uncharacterized conserved protein [Function unknown]; Region: COG2128 568707015183 Cupin domain; Region: Cupin_2; pfam07883 568707015184 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 568707015185 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 568707015186 dimerization interface [polypeptide binding]; other site 568707015187 domain crossover interface; other site 568707015188 redox-dependent activation switch; other site 568707015189 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 568707015190 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 568707015191 trimer interface [polypeptide binding]; other site 568707015192 putative metal binding site [ion binding]; other site 568707015193 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 568707015194 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 568707015195 active site 568707015196 acyl-activating enzyme (AAE) consensus motif; other site 568707015197 putative CoA binding site [chemical binding]; other site 568707015198 AMP binding site [chemical binding]; other site 568707015199 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568707015200 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 568707015201 putative active site [active] 568707015202 putative metal binding site [ion binding]; other site 568707015203 RDD family; Region: RDD; pfam06271 568707015204 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 568707015205 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 568707015206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 568707015207 S-adenosylmethionine binding site [chemical binding]; other site 568707015208 Predicted membrane protein [Function unknown]; Region: COG1981 568707015209 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 568707015210 2-methylcitrate dehydratase; Region: prpD; TIGR02330 568707015211 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 568707015212 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 568707015213 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 568707015214 substrate binding site [chemical binding]; other site 568707015215 ligand binding site [chemical binding]; other site 568707015216 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 568707015217 substrate binding site [chemical binding]; other site 568707015218 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 568707015219 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 568707015220 dimer interface [polypeptide binding]; other site 568707015221 active site 568707015222 citrylCoA binding site [chemical binding]; other site 568707015223 oxalacetate/citrate binding site [chemical binding]; other site 568707015224 coenzyme A binding site [chemical binding]; other site 568707015225 catalytic triad [active] 568707015226 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 568707015227 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 568707015228 tetramer interface [polypeptide binding]; other site 568707015229 active site 568707015230 Mg2+/Mn2+ binding site [ion binding]; other site 568707015231 malate dehydrogenase; Provisional; Region: PRK05442 568707015232 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 568707015233 NAD(P) binding site [chemical binding]; other site 568707015234 dimer interface [polypeptide binding]; other site 568707015235 malate binding site [chemical binding]; other site 568707015236 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568707015237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568707015238 DNA-binding site [nucleotide binding]; DNA binding site 568707015239 UTRA domain; Region: UTRA; pfam07702 568707015240 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 568707015241 Iron-sulfur protein interface; other site 568707015242 proximal quinone binding site [chemical binding]; other site 568707015243 SdhD (CybS) interface [polypeptide binding]; other site 568707015244 proximal heme binding site [chemical binding]; other site 568707015245 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 568707015246 SdhC subunit interface [polypeptide binding]; other site 568707015247 proximal heme binding site [chemical binding]; other site 568707015248 cardiolipin binding site; other site 568707015249 Iron-sulfur protein interface; other site 568707015250 proximal quinone binding site [chemical binding]; other site 568707015251 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 568707015252 L-aspartate oxidase; Provisional; Region: PRK06175 568707015253 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 568707015254 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 568707015255 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 568707015256 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 568707015257 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 568707015258 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 568707015259 dimer interface [polypeptide binding]; other site 568707015260 active site 568707015261 citrylCoA binding site [chemical binding]; other site 568707015262 NADH binding [chemical binding]; other site 568707015263 cationic pore residues; other site 568707015264 oxalacetate/citrate binding site [chemical binding]; other site 568707015265 coenzyme A binding site [chemical binding]; other site 568707015266 catalytic triad [active] 568707015267 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 568707015268 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 568707015269 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 568707015270 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568707015271 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 568707015272 putative NAD(P) binding site [chemical binding]; other site 568707015273 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 568707015274 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 568707015275 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 568707015276 dimer interface [polypeptide binding]; other site 568707015277 TPP-binding site [chemical binding]; other site 568707015278 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 568707015280 Predicted membrane protein [Function unknown]; Region: COG1297 568707015281 putative oligopeptide transporter, OPT family; Region: TIGR00733 568707015282 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 568707015283 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 568707015284 TPP-binding site [chemical binding]; other site 568707015285 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 568707015286 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 568707015287 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568707015288 E3 interaction surface; other site 568707015289 lipoyl attachment site [posttranslational modification]; other site 568707015290 e3 binding domain; Region: E3_binding; pfam02817 568707015291 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 568707015292 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 568707015293 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 568707015294 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568707015295 Predicted ATPase [General function prediction only]; Region: COG1485 568707015296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707015297 Walker B; other site 568707015298 D-loop; other site 568707015299 H-loop/switch region; other site 568707015300 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568707015301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568707015302 NAD(P) binding site [chemical binding]; other site 568707015303 active site 568707015304 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 568707015305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707015306 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 568707015307 dimerization interface [polypeptide binding]; other site 568707015308 substrate binding pocket [chemical binding]; other site 568707015309 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707015310 short chain dehydrogenase; Provisional; Region: PRK07577 568707015311 classical (c) SDRs; Region: SDR_c; cd05233 568707015312 NAD(P) binding site [chemical binding]; other site 568707015313 active site 568707015314 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 568707015315 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 568707015316 active site 568707015317 iron coordination sites [ion binding]; other site 568707015318 substrate binding pocket [chemical binding]; other site 568707015319 RNA polymerase sigma factor; Provisional; Region: PRK12528 568707015320 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568707015321 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 568707015322 DNA binding residues [nucleotide binding] 568707015323 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 568707015324 FecR protein; Region: FecR; pfam04773 568707015325 Secretin and TonB N terminus short domain; Region: STN; smart00965 568707015326 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 568707015327 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 568707015328 N-terminal plug; other site 568707015329 ligand-binding site [chemical binding]; other site 568707015330 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 568707015331 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 568707015332 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 568707015333 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 568707015334 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 568707015335 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 568707015336 active site 568707015337 HIGH motif; other site 568707015338 dimer interface [polypeptide binding]; other site 568707015339 KMSKS motif; other site 568707015340 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 568707015341 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 568707015342 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 568707015343 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 568707015344 RNA binding site [nucleotide binding]; other site 568707015345 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 568707015346 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 568707015347 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 568707015348 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 568707015349 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568707015350 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568707015351 RNA binding surface [nucleotide binding]; other site 568707015352 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 568707015353 active site 568707015354 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 568707015355 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 568707015356 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 568707015357 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 568707015358 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 568707015359 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 568707015360 NAD(P) binding site [chemical binding]; other site 568707015361 homotetramer interface [polypeptide binding]; other site 568707015362 homodimer interface [polypeptide binding]; other site 568707015363 active site 568707015364 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 568707015365 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 568707015366 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 568707015367 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 568707015368 Fe2+ transport protein; Region: Iron_transport; pfam10634 568707015369 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 568707015370 Iron permease FTR1 family; Region: FTR1; cl00475 568707015371 4Fe-4S binding domain; Region: Fer4_5; pfam12801 568707015372 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 568707015373 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 568707015374 CsbD-like; Region: CsbD; cl17424 568707015375 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 568707015376 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568707015377 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568707015378 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568707015379 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 568707015380 ATP-grasp domain; Region: ATP-grasp_4; cl17255 568707015381 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568707015382 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568707015383 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568707015384 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 568707015385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 568707015386 Walker A/P-loop; other site 568707015387 ATP binding site [chemical binding]; other site 568707015388 Q-loop/lid; other site 568707015389 ABC transporter signature motif; other site 568707015390 Walker B; other site 568707015391 D-loop; other site 568707015392 H-loop/switch region; other site 568707015393 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 568707015394 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 568707015395 Protein of unknown function, DUF482; Region: DUF482; pfam04339 568707015396 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 568707015397 dinuclear metal binding motif [ion binding]; other site 568707015398 Transglycosylase SLT domain; Region: SLT_2; pfam13406 568707015399 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 568707015400 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568707015401 catalytic residue [active] 568707015402 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568707015403 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 568707015404 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568707015405 Ligand Binding Site [chemical binding]; other site 568707015406 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568707015407 Ligand Binding Site [chemical binding]; other site 568707015408 Cache domain; Region: Cache_1; pfam02743 568707015409 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 568707015410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 568707015411 metal binding site [ion binding]; metal-binding site 568707015412 active site 568707015413 I-site; other site 568707015414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568707015415 putative substrate translocation pore; other site 568707015416 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 568707015417 dimer interface [polypeptide binding]; other site 568707015418 FMN binding site [chemical binding]; other site 568707015419 NADPH bind site [chemical binding]; other site 568707015420 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707015421 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 568707015422 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 568707015423 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 568707015424 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 568707015425 aspartate aminotransferase; Provisional; Region: PRK05764 568707015426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568707015427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568707015428 homodimer interface [polypeptide binding]; other site 568707015429 catalytic residue [active] 568707015430 hypothetical protein; Provisional; Region: PRK06163 568707015431 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 568707015432 TPP-binding site [chemical binding]; other site 568707015433 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568707015434 PYR/PP interface [polypeptide binding]; other site 568707015435 dimer interface [polypeptide binding]; other site 568707015436 TPP binding site [chemical binding]; other site 568707015437 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707015438 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707015439 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707015440 dimerization interface [polypeptide binding]; other site 568707015441 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 568707015442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 568707015443 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707015444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707015445 dimer interface [polypeptide binding]; other site 568707015446 conserved gate region; other site 568707015447 putative PBP binding loops; other site 568707015448 ABC-ATPase subunit interface; other site 568707015449 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568707015450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 568707015451 dimer interface [polypeptide binding]; other site 568707015452 conserved gate region; other site 568707015453 putative PBP binding loops; other site 568707015454 ABC-ATPase subunit interface; other site 568707015455 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 568707015456 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 568707015457 Walker A/P-loop; other site 568707015458 ATP binding site [chemical binding]; other site 568707015459 Q-loop/lid; other site 568707015460 ABC transporter signature motif; other site 568707015461 Walker B; other site 568707015462 D-loop; other site 568707015463 H-loop/switch region; other site 568707015464 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 568707015465 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568707015466 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 568707015467 NAD(P) binding site [chemical binding]; other site 568707015468 catalytic residues [active] 568707015469 tricarballylate dehydrogenase; Validated; Region: PRK08274 568707015470 tricarballylate utilization protein B; Provisional; Region: PRK15033 568707015471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 568707015472 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 568707015473 Predicted transcriptional regulators [Transcription]; Region: COG1378 568707015474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568707015475 dimerization interface [polypeptide binding]; other site 568707015476 putative Zn2+ binding site [ion binding]; other site 568707015477 putative DNA binding site [nucleotide binding]; other site 568707015478 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 568707015479 C-terminal domain interface [polypeptide binding]; other site 568707015480 sugar binding site [chemical binding]; other site 568707015481 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 568707015482 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 568707015483 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 568707015484 active site 568707015485 iron coordination sites [ion binding]; other site 568707015486 substrate binding pocket [chemical binding]; other site 568707015487 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707015488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707015489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707015490 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568707015491 dimerization interface [polypeptide binding]; other site 568707015492 Restriction endonuclease; Region: Mrr_cat; pfam04471 568707015493 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 568707015494 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 568707015495 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 568707015496 acyl-activating enzyme (AAE) consensus motif; other site 568707015497 putative AMP binding site [chemical binding]; other site 568707015498 putative active site [active] 568707015499 putative CoA binding site [chemical binding]; other site 568707015500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 568707015501 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 568707015502 DUF35 OB-fold domain; Region: DUF35; pfam01796 568707015503 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 568707015504 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 568707015505 active site 568707015506 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 568707015507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568707015508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 568707015509 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 568707015510 dimerization interface [polypeptide binding]; other site 568707015511 substrate binding pocket [chemical binding]; other site 568707015512 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 568707015513 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 568707015514 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568707015515 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 568707015516 Int/Topo IB signature motif; other site 568707015517 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 568707015518 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 568707015519 RecT family; Region: RecT; pfam03837 568707015520 RecT family; Region: RecT; pfam03837 568707015521 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 568707015522 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 568707015523 catalytic residue [active] 568707015524 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 568707015525 active site 568707015526 putative DNA-binding cleft [nucleotide binding]; other site 568707015527 dimer interface [polypeptide binding]; other site 568707015528 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 568707015529 AAA domain; Region: AAA_25; pfam13481 568707015530 Walker A motif; other site 568707015531 ATP binding site [chemical binding]; other site 568707015532 Walker B motif; other site 568707015533 RecT family; Region: RecT; pfam03837 568707015534 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588