-- dump date 20140619_004041 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1017264000001 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1017264000002 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1017264000003 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1017264000004 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1017264000005 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1017264000006 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1017264000007 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1017264000008 P-loop; other site 1017264000009 Magnesium ion binding site [ion binding]; other site 1017264000010 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1017264000011 Magnesium ion binding site [ion binding]; other site 1017264000012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1017264000013 Coenzyme A binding pocket [chemical binding]; other site 1017264000014 ParB-like nuclease domain; Region: ParB; smart00470 1017264000015 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1017264000016 elongation factor Tu; Reviewed; Region: PRK00049 1017264000017 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1017264000018 G1 box; other site 1017264000019 GEF interaction site [polypeptide binding]; other site 1017264000020 GTP/Mg2+ binding site [chemical binding]; other site 1017264000021 Switch I region; other site 1017264000022 G2 box; other site 1017264000023 G3 box; other site 1017264000024 Switch II region; other site 1017264000025 G4 box; other site 1017264000026 G5 box; other site 1017264000027 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1017264000028 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1017264000029 Antibiotic Binding Site [chemical binding]; other site 1017264000030 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1017264000031 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1017264000032 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1017264000033 putative homodimer interface [polypeptide binding]; other site 1017264000034 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1017264000035 heterodimer interface [polypeptide binding]; other site 1017264000036 homodimer interface [polypeptide binding]; other site 1017264000037 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1017264000038 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1017264000039 23S rRNA interface [nucleotide binding]; other site 1017264000040 L7/L12 interface [polypeptide binding]; other site 1017264000041 putative thiostrepton binding site; other site 1017264000042 L25 interface [polypeptide binding]; other site 1017264000043 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1017264000044 mRNA/rRNA interface [nucleotide binding]; other site 1017264000045 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1017264000046 23S rRNA interface [nucleotide binding]; other site 1017264000047 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1017264000048 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1017264000049 core dimer interface [polypeptide binding]; other site 1017264000050 peripheral dimer interface [polypeptide binding]; other site 1017264000051 L10 interface [polypeptide binding]; other site 1017264000052 L11 interface [polypeptide binding]; other site 1017264000053 putative EF-Tu interaction site [polypeptide binding]; other site 1017264000054 putative EF-G interaction site [polypeptide binding]; other site 1017264000055 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1017264000056 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1017264000057 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1017264000058 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1017264000059 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1017264000060 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1017264000061 RPB3 interaction site [polypeptide binding]; other site 1017264000062 RPB1 interaction site [polypeptide binding]; other site 1017264000063 RPB11 interaction site [polypeptide binding]; other site 1017264000064 RPB10 interaction site [polypeptide binding]; other site 1017264000065 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1017264000066 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1017264000067 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1017264000068 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1017264000069 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1017264000070 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1017264000071 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1017264000072 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1017264000073 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1017264000074 DNA binding site [nucleotide binding] 1017264000075 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1017264000076 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1017264000077 substrate binding site [chemical binding]; other site 1017264000078 activation loop (A-loop); other site 1017264000079 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1017264000080 FecR protein; Region: FecR; pfam04773 1017264000081 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1017264000082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264000083 active site 1017264000084 phosphorylation site [posttranslational modification] 1017264000085 intermolecular recognition site; other site 1017264000086 dimerization interface [polypeptide binding]; other site 1017264000087 DNA binding site [nucleotide binding] 1017264000088 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1017264000089 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000090 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000091 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000092 Integrase core domain; Region: rve; pfam00665 1017264000093 Integrase core domain; Region: rve_3; pfam13683 1017264000094 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1017264000095 DUF35 OB-fold domain; Region: DUF35; pfam01796 1017264000096 thiolase; Provisional; Region: PRK06158 1017264000097 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1017264000098 active site 1017264000099 MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446 1017264000100 homodimer interaction site [polypeptide binding]; other site 1017264000101 putative active site [active] 1017264000102 putative catalytic site [active] 1017264000103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264000104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264000105 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264000106 dimerization interface [polypeptide binding]; other site 1017264000107 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1017264000108 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264000109 substrate binding site [chemical binding]; other site 1017264000110 oxyanion hole (OAH) forming residues; other site 1017264000111 trimer interface [polypeptide binding]; other site 1017264000112 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1017264000113 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000114 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000115 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000116 Integrase core domain; Region: rve; pfam00665 1017264000117 Integrase core domain; Region: rve_3; pfam13683 1017264000118 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1017264000119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264000120 putative substrate translocation pore; other site 1017264000121 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1017264000122 dimer interface [polypeptide binding]; other site 1017264000123 motif 1; other site 1017264000124 active site 1017264000125 motif 2; other site 1017264000126 motif 3; other site 1017264000127 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1017264000128 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1017264000129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1017264000130 active site 1017264000131 motif I; other site 1017264000132 motif II; other site 1017264000133 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1017264000134 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1017264000135 putative acyl-acceptor binding pocket; other site 1017264000136 Protein of unknown function DUF45; Region: DUF45; pfam01863 1017264000137 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1017264000138 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1017264000139 dimer interface [polypeptide binding]; other site 1017264000140 active site 1017264000141 metal binding site [ion binding]; metal-binding site 1017264000142 glutathione binding site [chemical binding]; other site 1017264000143 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1017264000144 active site 1017264000145 catalytic residues [active] 1017264000146 metal binding site [ion binding]; metal-binding site 1017264000147 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000148 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000149 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000150 Integrase core domain; Region: rve; pfam00665 1017264000151 Integrase core domain; Region: rve_3; pfam13683 1017264000152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1017264000153 DNA binding residues [nucleotide binding] 1017264000154 Membrane transport protein; Region: Mem_trans; cl09117 1017264000155 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1017264000156 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1017264000157 methionine biosynthesis protein MetW; Region: metW; TIGR02081 1017264000158 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000159 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000160 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000161 Integrase core domain; Region: rve; pfam00665 1017264000162 Integrase core domain; Region: rve_3; pfam13683 1017264000163 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1017264000164 muropeptide transporter; Validated; Region: ampG; cl17669 1017264000165 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1017264000166 aspartate racemase; Region: asp_race; TIGR00035 1017264000167 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1017264000168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264000169 dimer interface [polypeptide binding]; other site 1017264000170 conserved gate region; other site 1017264000171 putative PBP binding loops; other site 1017264000172 ABC-ATPase subunit interface; other site 1017264000173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264000174 dimer interface [polypeptide binding]; other site 1017264000175 conserved gate region; other site 1017264000176 putative PBP binding loops; other site 1017264000177 ABC-ATPase subunit interface; other site 1017264000178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264000179 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1017264000180 substrate binding pocket [chemical binding]; other site 1017264000181 membrane-bound complex binding site; other site 1017264000182 hinge residues; other site 1017264000183 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000184 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000185 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000186 Integrase core domain; Region: rve; pfam00665 1017264000187 Integrase core domain; Region: rve_3; pfam13683 1017264000188 HipA N-terminal domain; Region: Couple_hipA; cl11853 1017264000189 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1017264000190 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1017264000191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1017264000192 non-specific DNA binding site [nucleotide binding]; other site 1017264000193 salt bridge; other site 1017264000194 sequence-specific DNA binding site [nucleotide binding]; other site 1017264000195 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264000196 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1017264000197 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1017264000198 conserved cys residue [active] 1017264000199 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1017264000200 iron-sulfur cluster [ion binding]; other site 1017264000201 [2Fe-2S] cluster binding site [ion binding]; other site 1017264000202 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264000203 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1017264000204 catalytic loop [active] 1017264000205 iron binding site [ion binding]; other site 1017264000206 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1017264000207 FAD binding pocket [chemical binding]; other site 1017264000208 conserved FAD binding motif [chemical binding]; other site 1017264000209 phosphate binding motif [ion binding]; other site 1017264000210 beta-alpha-beta structure motif; other site 1017264000211 NAD binding pocket [chemical binding]; other site 1017264000212 DctM-like transporters; Region: DctM; pfam06808 1017264000213 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1017264000214 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1017264000215 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000216 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000217 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000218 Integrase core domain; Region: rve; pfam00665 1017264000219 Integrase core domain; Region: rve_3; pfam13683 1017264000220 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 1017264000221 heat shock protein 90; Provisional; Region: PRK05218 1017264000222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264000223 ATP binding site [chemical binding]; other site 1017264000224 Mg2+ binding site [ion binding]; other site 1017264000225 G-X-G motif; other site 1017264000226 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1017264000227 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1017264000228 putative C-terminal domain interface [polypeptide binding]; other site 1017264000229 putative GSH binding site (G-site) [chemical binding]; other site 1017264000230 putative dimer interface [polypeptide binding]; other site 1017264000231 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1017264000232 putative N-terminal domain interface [polypeptide binding]; other site 1017264000233 putative dimer interface [polypeptide binding]; other site 1017264000234 putative substrate binding pocket (H-site) [chemical binding]; other site 1017264000235 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1017264000236 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1017264000237 amidase catalytic site [active] 1017264000238 Zn binding residues [ion binding]; other site 1017264000239 substrate binding site [chemical binding]; other site 1017264000240 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1017264000241 signal recognition particle protein; Provisional; Region: PRK10867 1017264000242 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1017264000243 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1017264000244 GTP binding site [chemical binding]; other site 1017264000245 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1017264000246 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000247 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000248 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000249 Integrase core domain; Region: rve; pfam00665 1017264000250 Integrase core domain; Region: rve_3; pfam13683 1017264000251 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1017264000252 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1017264000253 NAD(P) binding site [chemical binding]; other site 1017264000254 homodimer interface [polypeptide binding]; other site 1017264000255 substrate binding site [chemical binding]; other site 1017264000256 active site 1017264000257 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1017264000258 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1017264000259 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1017264000260 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1017264000261 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1017264000262 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1017264000263 inhibitor-cofactor binding pocket; inhibition site 1017264000264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264000265 catalytic residue [active] 1017264000266 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1017264000267 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1017264000268 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1017264000269 active site 1017264000270 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1017264000271 homodimer interface [polypeptide binding]; other site 1017264000272 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1017264000273 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1017264000274 inhibitor-cofactor binding pocket; inhibition site 1017264000275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264000276 catalytic residue [active] 1017264000277 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 1017264000278 putative CoA binding site [chemical binding]; other site 1017264000279 putative trimer interface [polypeptide binding]; other site 1017264000280 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1017264000281 putative trimer interface [polypeptide binding]; other site 1017264000282 putative active site [active] 1017264000283 putative substrate binding site [chemical binding]; other site 1017264000284 putative CoA binding site [chemical binding]; other site 1017264000285 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1017264000286 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1017264000287 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1017264000288 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1017264000289 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1017264000290 putative active site [active] 1017264000291 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1017264000292 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1017264000293 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1017264000294 pantothenate kinase; Reviewed; Region: PRK13328 1017264000295 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1017264000296 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1017264000297 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1017264000298 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1017264000299 Permease; Region: Permease; pfam02405 1017264000300 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1017264000301 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1017264000302 Walker A/P-loop; other site 1017264000303 ATP binding site [chemical binding]; other site 1017264000304 Q-loop/lid; other site 1017264000305 ABC transporter signature motif; other site 1017264000306 Walker B; other site 1017264000307 D-loop; other site 1017264000308 H-loop/switch region; other site 1017264000309 Protein of unknown function (DUF330); Region: DUF330; cl01135 1017264000310 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1017264000311 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1017264000312 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1017264000313 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1017264000314 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1017264000315 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1017264000316 homodimer interface [polypeptide binding]; other site 1017264000317 substrate-cofactor binding pocket; other site 1017264000318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264000319 catalytic residue [active] 1017264000320 hypothetical protein; Provisional; Region: PRK02047 1017264000321 lipoate-protein ligase B; Provisional; Region: PRK14349 1017264000322 lipoyl synthase; Provisional; Region: PRK05481 1017264000323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1017264000324 FeS/SAM binding site; other site 1017264000325 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1017264000326 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1017264000327 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1017264000328 NADP binding site [chemical binding]; other site 1017264000329 active site 1017264000330 putative substrate binding site [chemical binding]; other site 1017264000331 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1017264000332 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1017264000333 NAD binding site [chemical binding]; other site 1017264000334 substrate binding site [chemical binding]; other site 1017264000335 homodimer interface [polypeptide binding]; other site 1017264000336 active site 1017264000337 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000338 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000339 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000340 Integrase core domain; Region: rve; pfam00665 1017264000341 Integrase core domain; Region: rve_3; pfam13683 1017264000342 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1017264000343 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1017264000344 homodimer interface [polypeptide binding]; other site 1017264000345 substrate-cofactor binding pocket; other site 1017264000346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264000347 catalytic residue [active] 1017264000348 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1017264000349 catalytic residues [active] 1017264000350 hinge region; other site 1017264000351 alpha helical domain; other site 1017264000352 Sporulation related domain; Region: SPOR; pfam05036 1017264000353 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1017264000354 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1017264000355 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1017264000356 active site 1017264000357 HIGH motif; other site 1017264000358 KMSK motif region; other site 1017264000359 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1017264000360 tRNA binding surface [nucleotide binding]; other site 1017264000361 anticodon binding site; other site 1017264000362 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 1017264000363 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264000364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264000365 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264000366 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1017264000367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264000368 dimer interface [polypeptide binding]; other site 1017264000369 conserved gate region; other site 1017264000370 putative PBP binding loops; other site 1017264000371 ABC-ATPase subunit interface; other site 1017264000372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264000373 dimer interface [polypeptide binding]; other site 1017264000374 conserved gate region; other site 1017264000375 putative PBP binding loops; other site 1017264000376 ABC-ATPase subunit interface; other site 1017264000377 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1017264000378 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1017264000379 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1017264000380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264000381 Walker A/P-loop; other site 1017264000382 ATP binding site [chemical binding]; other site 1017264000383 Q-loop/lid; other site 1017264000384 ABC transporter signature motif; other site 1017264000385 Walker B; other site 1017264000386 D-loop; other site 1017264000387 H-loop/switch region; other site 1017264000388 TOBE domain; Region: TOBE_2; pfam08402 1017264000389 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1017264000390 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1017264000391 active site 1017264000392 metal binding site [ion binding]; metal-binding site 1017264000393 hexamer interface [polypeptide binding]; other site 1017264000394 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000395 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000396 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000397 Integrase core domain; Region: rve; pfam00665 1017264000398 Integrase core domain; Region: rve_3; pfam13683 1017264000399 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1017264000400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264000401 dimer interface [polypeptide binding]; other site 1017264000402 conserved gate region; other site 1017264000403 putative PBP binding loops; other site 1017264000404 ABC-ATPase subunit interface; other site 1017264000405 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1017264000406 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1017264000407 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1017264000408 Amidase; Region: Amidase; cl11426 1017264000409 2-isopropylmalate synthase; Validated; Region: PRK03739 1017264000410 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1017264000411 active site 1017264000412 catalytic residues [active] 1017264000413 metal binding site [ion binding]; metal-binding site 1017264000414 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1017264000415 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1017264000416 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1017264000417 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1017264000418 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1017264000419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264000420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264000421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264000422 dimerization interface [polypeptide binding]; other site 1017264000423 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000424 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000425 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000426 Integrase core domain; Region: rve; pfam00665 1017264000427 Integrase core domain; Region: rve_3; pfam13683 1017264000428 threonine dehydratase; Reviewed; Region: PRK09224 1017264000429 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1017264000430 tetramer interface [polypeptide binding]; other site 1017264000431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264000432 catalytic residue [active] 1017264000433 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1017264000434 putative Ile/Val binding site [chemical binding]; other site 1017264000435 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1017264000436 putative Ile/Val binding site [chemical binding]; other site 1017264000437 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 1017264000438 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1017264000439 FAD binding domain; Region: FAD_binding_4; pfam01565 1017264000440 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1017264000441 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1017264000442 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1017264000443 Cysteine-rich domain; Region: CCG; pfam02754 1017264000444 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 1017264000445 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1017264000446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264000447 DNA-binding site [nucleotide binding]; DNA binding site 1017264000448 FCD domain; Region: FCD; pfam07729 1017264000449 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264000450 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264000451 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1017264000452 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1017264000453 enoyl-CoA hydratase; Provisional; Region: PRK08290 1017264000454 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264000455 substrate binding site [chemical binding]; other site 1017264000456 oxyanion hole (OAH) forming residues; other site 1017264000457 trimer interface [polypeptide binding]; other site 1017264000458 Tripartite tricarboxylate transporter family receptor; Region: TctC; pfam03401 1017264000459 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264000460 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1017264000461 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264000462 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1017264000463 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1017264000464 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1017264000465 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1017264000466 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1017264000467 putative metal binding site [ion binding]; other site 1017264000468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264000469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264000470 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 1017264000471 putative dimerization interface [polypeptide binding]; other site 1017264000472 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1017264000473 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1017264000474 ligand binding site [chemical binding]; other site 1017264000475 NAD binding site [chemical binding]; other site 1017264000476 tetramer interface [polypeptide binding]; other site 1017264000477 catalytic site [active] 1017264000478 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1017264000479 L-serine binding site [chemical binding]; other site 1017264000480 ACT domain interface; other site 1017264000481 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1017264000482 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1017264000483 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1017264000484 dimerization interface [polypeptide binding]; other site 1017264000485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264000486 dimer interface [polypeptide binding]; other site 1017264000487 phosphorylation site [posttranslational modification] 1017264000488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264000489 ATP binding site [chemical binding]; other site 1017264000490 G-X-G motif; other site 1017264000491 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1017264000492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264000493 active site 1017264000494 phosphorylation site [posttranslational modification] 1017264000495 intermolecular recognition site; other site 1017264000496 dimerization interface [polypeptide binding]; other site 1017264000497 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1017264000498 DNA binding site [nucleotide binding] 1017264000499 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1017264000500 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1017264000501 PAS domain; Region: PAS; smart00091 1017264000502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264000503 dimer interface [polypeptide binding]; other site 1017264000504 phosphorylation site [posttranslational modification] 1017264000505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264000506 ATP binding site [chemical binding]; other site 1017264000507 G-X-G motif; other site 1017264000508 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1017264000509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264000510 active site 1017264000511 phosphorylation site [posttranslational modification] 1017264000512 intermolecular recognition site; other site 1017264000513 dimerization interface [polypeptide binding]; other site 1017264000514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1017264000515 DNA binding site [nucleotide binding] 1017264000516 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1017264000517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264000518 S-adenosylmethionine binding site [chemical binding]; other site 1017264000519 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 1017264000520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1017264000521 SCP-2 sterol transfer family; Region: SCP2; cl01225 1017264000522 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1017264000523 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1017264000524 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000525 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000526 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000527 Integrase core domain; Region: rve; pfam00665 1017264000528 Integrase core domain; Region: rve_3; pfam13683 1017264000529 Repair protein; Region: Repair_PSII; pfam04536 1017264000530 LemA family; Region: LemA; pfam04011 1017264000531 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1017264000532 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1017264000533 ATP binding site [chemical binding]; other site 1017264000534 Mg++ binding site [ion binding]; other site 1017264000535 motif III; other site 1017264000536 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1017264000537 nucleotide binding region [chemical binding]; other site 1017264000538 ATP-binding site [chemical binding]; other site 1017264000539 LysE type translocator; Region: LysE; cl00565 1017264000540 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1017264000541 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1017264000542 G1 box; other site 1017264000543 putative GEF interaction site [polypeptide binding]; other site 1017264000544 GTP/Mg2+ binding site [chemical binding]; other site 1017264000545 Switch I region; other site 1017264000546 G2 box; other site 1017264000547 G3 box; other site 1017264000548 Switch II region; other site 1017264000549 G4 box; other site 1017264000550 G5 box; other site 1017264000551 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1017264000552 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1017264000553 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1017264000554 heme binding site [chemical binding]; other site 1017264000555 ferroxidase pore; other site 1017264000556 ferroxidase diiron center [ion binding]; other site 1017264000557 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000558 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000559 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000560 Integrase core domain; Region: rve; pfam00665 1017264000561 Integrase core domain; Region: rve_3; pfam13683 1017264000562 META domain; Region: META; pfam03724 1017264000563 META domain; Region: META; pfam03724 1017264000564 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 1017264000565 rhodanese superfamily protein; Provisional; Region: PRK05320 1017264000566 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1017264000567 active site residue [active] 1017264000568 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1017264000569 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1017264000570 active site 1017264000571 HIGH motif; other site 1017264000572 KMSKS motif; other site 1017264000573 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1017264000574 tRNA binding surface [nucleotide binding]; other site 1017264000575 anticodon binding site; other site 1017264000576 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1017264000577 dimer interface [polypeptide binding]; other site 1017264000578 putative tRNA-binding site [nucleotide binding]; other site 1017264000579 Domain of unknown function DUF59; Region: DUF59; cl00941 1017264000580 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1017264000581 Walker A motif; other site 1017264000582 Surface antigen; Region: Bac_surface_Ag; pfam01103 1017264000583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1017264000584 Family of unknown function (DUF490); Region: DUF490; pfam04357 1017264000585 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1017264000586 trimer interface [polypeptide binding]; other site 1017264000587 active site 1017264000588 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1017264000589 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1017264000590 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1017264000591 active site 1017264000592 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1017264000593 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1017264000594 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1017264000595 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1017264000596 catalytic residue [active] 1017264000597 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1017264000598 HI0933-like protein; Region: HI0933_like; pfam03486 1017264000599 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000600 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000601 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000602 Integrase core domain; Region: rve; pfam00665 1017264000603 Integrase core domain; Region: rve_3; pfam13683 1017264000604 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1017264000605 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1017264000606 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1017264000607 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1017264000608 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1017264000609 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1017264000610 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1017264000611 lipoyl attachment site [posttranslational modification]; other site 1017264000612 glycine dehydrogenase; Provisional; Region: PRK05367 1017264000613 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1017264000614 tetramer interface [polypeptide binding]; other site 1017264000615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264000616 catalytic residue [active] 1017264000617 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1017264000618 tetramer interface [polypeptide binding]; other site 1017264000619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264000620 catalytic residue [active] 1017264000621 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1017264000622 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264000623 DNA-binding site [nucleotide binding]; DNA binding site 1017264000624 FCD domain; Region: FCD; pfam07729 1017264000625 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264000626 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264000627 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1017264000628 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264000629 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000630 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000631 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000632 Integrase core domain; Region: rve; pfam00665 1017264000633 Integrase core domain; Region: rve_3; pfam13683 1017264000634 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000635 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000636 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000637 Integrase core domain; Region: rve; pfam00665 1017264000638 Integrase core domain; Region: rve_3; pfam13683 1017264000639 HindIII restriction endonuclease; Region: RE_HindIII; pfam09518 1017264000640 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1017264000641 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1017264000642 ThiC-associated domain; Region: ThiC-associated; pfam13667 1017264000643 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1017264000644 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1017264000645 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1017264000646 NAD(P) binding site [chemical binding]; other site 1017264000647 catalytic residues [active] 1017264000648 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1017264000649 FAD binding domain; Region: FAD_binding_4; pfam01565 1017264000650 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1017264000651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264000652 DNA-binding site [nucleotide binding]; DNA binding site 1017264000653 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1017264000654 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000655 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000656 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000657 Integrase core domain; Region: rve; pfam00665 1017264000658 Integrase core domain; Region: rve_3; pfam13683 1017264000659 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000660 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000661 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000662 Integrase core domain; Region: rve; pfam00665 1017264000663 Integrase core domain; Region: rve_3; pfam13683 1017264000664 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1017264000665 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1017264000666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1017264000667 Coenzyme A binding pocket [chemical binding]; other site 1017264000668 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1017264000669 Ligand Binding Site [chemical binding]; other site 1017264000670 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1017264000671 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1017264000672 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 1017264000673 catalytic triad [active] 1017264000674 putative active site [active] 1017264000675 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1017264000676 catalytic residues [active] 1017264000677 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1017264000678 Autotransporter beta-domain; Region: Autotransporter; smart00869 1017264000679 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 1017264000680 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1017264000681 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1017264000682 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1017264000683 short chain dehydrogenase; Provisional; Region: PRK07577 1017264000684 classical (c) SDRs; Region: SDR_c; cd05233 1017264000685 NAD(P) binding site [chemical binding]; other site 1017264000686 active site 1017264000687 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1017264000688 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1017264000689 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264000690 Coenzyme A transferase; Region: CoA_trans; cl17247 1017264000691 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1017264000692 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1017264000693 YciI-like protein; Reviewed; Region: PRK12863 1017264000694 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1017264000695 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1017264000696 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1017264000697 Putative cyclase; Region: Cyclase; pfam04199 1017264000698 psiF repeat; Region: PsiF_repeat; pfam07769 1017264000699 psiF repeat; Region: PsiF_repeat; pfam07769 1017264000700 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000701 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000702 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000703 Integrase core domain; Region: rve; pfam00665 1017264000704 Integrase core domain; Region: rve_3; pfam13683 1017264000705 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1017264000706 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1017264000707 Walker A/P-loop; other site 1017264000708 ATP binding site [chemical binding]; other site 1017264000709 Q-loop/lid; other site 1017264000710 ABC transporter signature motif; other site 1017264000711 Walker B; other site 1017264000712 D-loop; other site 1017264000713 H-loop/switch region; other site 1017264000714 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1017264000715 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264000716 Walker A/P-loop; other site 1017264000717 ATP binding site [chemical binding]; other site 1017264000718 Q-loop/lid; other site 1017264000719 ABC transporter signature motif; other site 1017264000720 Walker B; other site 1017264000721 D-loop; other site 1017264000722 H-loop/switch region; other site 1017264000723 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1017264000724 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1017264000725 TM-ABC transporter signature motif; other site 1017264000726 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264000727 TM-ABC transporter signature motif; other site 1017264000728 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1017264000729 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 1017264000730 putative ligand binding site [chemical binding]; other site 1017264000731 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1017264000732 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1017264000733 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1017264000734 MarR family; Region: MarR; pfam01047 1017264000735 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000736 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000737 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000738 Integrase core domain; Region: rve; pfam00665 1017264000739 Integrase core domain; Region: rve_3; pfam13683 1017264000740 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000741 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000742 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000743 Integrase core domain; Region: rve; pfam00665 1017264000744 Integrase core domain; Region: rve_3; pfam13683 1017264000745 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1017264000746 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264000747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264000748 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264000749 dimerization interface [polypeptide binding]; other site 1017264000750 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1017264000751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264000752 putative substrate translocation pore; other site 1017264000753 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1017264000754 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1017264000755 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1017264000756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1017264000757 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1017264000758 active site 1017264000759 catalytic residues [active] 1017264000760 metal binding site [ion binding]; metal-binding site 1017264000761 Cupin domain; Region: Cupin_2; pfam07883 1017264000762 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1017264000763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1017264000764 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1017264000765 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1017264000766 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1017264000767 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1017264000768 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1017264000769 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1017264000770 putative ligand binding site [chemical binding]; other site 1017264000771 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1017264000772 NAD binding site [chemical binding]; other site 1017264000773 dimerization interface [polypeptide binding]; other site 1017264000774 catalytic site [active] 1017264000775 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1017264000776 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000777 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000778 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000779 Integrase core domain; Region: rve; pfam00665 1017264000780 Integrase core domain; Region: rve_3; pfam13683 1017264000781 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1017264000782 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1017264000783 protein binding site [polypeptide binding]; other site 1017264000784 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1017264000785 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1017264000786 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1017264000787 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1017264000788 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1017264000789 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1017264000790 [2Fe-2S] cluster binding site [ion binding]; other site 1017264000791 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1017264000792 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1017264000793 Qi binding site; other site 1017264000794 intrachain domain interface; other site 1017264000795 interchain domain interface [polypeptide binding]; other site 1017264000796 heme bH binding site [chemical binding]; other site 1017264000797 heme bL binding site [chemical binding]; other site 1017264000798 Qo binding site; other site 1017264000799 interchain domain interface [polypeptide binding]; other site 1017264000800 intrachain domain interface; other site 1017264000801 Qi binding site; other site 1017264000802 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 1017264000803 Qo binding site; other site 1017264000804 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1017264000805 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1017264000806 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1017264000807 C-terminal domain interface [polypeptide binding]; other site 1017264000808 putative GSH binding site (G-site) [chemical binding]; other site 1017264000809 dimer interface [polypeptide binding]; other site 1017264000810 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1017264000811 dimer interface [polypeptide binding]; other site 1017264000812 N-terminal domain interface [polypeptide binding]; other site 1017264000813 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1017264000814 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1017264000815 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 1017264000816 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000817 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000818 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000819 Integrase core domain; Region: rve; pfam00665 1017264000820 Integrase core domain; Region: rve_3; pfam13683 1017264000821 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1017264000822 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1017264000823 active site 1017264000824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264000825 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1017264000826 Walker A/P-loop; other site 1017264000827 ATP binding site [chemical binding]; other site 1017264000828 Q-loop/lid; other site 1017264000829 ABC transporter signature motif; other site 1017264000830 Walker B; other site 1017264000831 D-loop; other site 1017264000832 H-loop/switch region; other site 1017264000833 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1017264000834 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1017264000835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264000836 Walker A/P-loop; other site 1017264000837 ATP binding site [chemical binding]; other site 1017264000838 Q-loop/lid; other site 1017264000839 ABC transporter signature motif; other site 1017264000840 Walker B; other site 1017264000841 D-loop; other site 1017264000842 H-loop/switch region; other site 1017264000843 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 1017264000844 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1017264000845 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1017264000846 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1017264000847 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1017264000848 Predicted transcriptional regulators [Transcription]; Region: COG1510 1017264000849 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264000850 dimerization interface [polypeptide binding]; other site 1017264000851 putative DNA binding site [nucleotide binding]; other site 1017264000852 putative Zn2+ binding site [ion binding]; other site 1017264000853 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264000854 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264000855 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264000856 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1017264000857 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1017264000858 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1017264000859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264000860 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264000861 dimerization interface [polypeptide binding]; other site 1017264000862 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264000863 Predicted permeases [General function prediction only]; Region: COG0679 1017264000864 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1017264000865 Class II fumarases; Region: Fumarase_classII; cd01362 1017264000866 active site 1017264000867 tetramer interface [polypeptide binding]; other site 1017264000868 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1017264000869 AMIN domain; Region: AMIN; pfam11741 1017264000870 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1017264000871 active site 1017264000872 metal binding site [ion binding]; metal-binding site 1017264000873 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1017264000874 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1017264000875 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 1017264000876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264000877 ATP binding site [chemical binding]; other site 1017264000878 Mg2+ binding site [ion binding]; other site 1017264000879 G-X-G motif; other site 1017264000880 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1017264000881 ATP binding site [chemical binding]; other site 1017264000882 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1017264000883 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1017264000884 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1017264000885 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1017264000886 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1017264000887 dimerization interface [polypeptide binding]; other site 1017264000888 putative ATP binding site [chemical binding]; other site 1017264000889 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 1017264000890 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1017264000891 Walker A motif; other site 1017264000892 ATP binding site [chemical binding]; other site 1017264000893 Walker B motif; other site 1017264000894 arginine finger; other site 1017264000895 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1017264000896 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1017264000897 poly(A) polymerase; Region: pcnB; TIGR01942 1017264000898 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1017264000899 active site 1017264000900 NTP binding site [chemical binding]; other site 1017264000901 metal binding triad [ion binding]; metal-binding site 1017264000902 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1017264000903 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1017264000904 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1017264000905 catalytic center binding site [active] 1017264000906 ATP binding site [chemical binding]; other site 1017264000907 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264000908 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1017264000909 DctM-like transporters; Region: DctM; pfam06808 1017264000910 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1017264000911 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1017264000912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264000913 DNA-binding site [nucleotide binding]; DNA binding site 1017264000914 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1017264000915 FCD domain; Region: FCD; pfam07729 1017264000916 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1017264000917 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1017264000918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264000919 NAD(P) binding site [chemical binding]; other site 1017264000920 active site 1017264000921 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000922 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000923 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000924 Integrase core domain; Region: rve; pfam00665 1017264000925 Integrase core domain; Region: rve_3; pfam13683 1017264000926 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1017264000927 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264000928 substrate binding site [chemical binding]; other site 1017264000929 oxyanion hole (OAH) forming residues; other site 1017264000930 trimer interface [polypeptide binding]; other site 1017264000931 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1017264000932 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1017264000933 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1017264000934 active site 1017264000935 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1017264000936 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1017264000937 acyl-activating enzyme (AAE) consensus motif; other site 1017264000938 AMP binding site [chemical binding]; other site 1017264000939 active site 1017264000940 CoA binding site [chemical binding]; other site 1017264000941 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1017264000942 active site 1017264000943 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1017264000944 homotrimer interaction site [polypeptide binding]; other site 1017264000945 putative active site [active] 1017264000946 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1017264000947 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1017264000948 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1017264000949 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1017264000950 inhibitor-cofactor binding pocket; inhibition site 1017264000951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264000952 catalytic residue [active] 1017264000953 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1017264000954 thiamine phosphate binding site [chemical binding]; other site 1017264000955 active site 1017264000956 pyrophosphate binding site [ion binding]; other site 1017264000957 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1017264000958 substrate binding site [chemical binding]; other site 1017264000959 dimer interface [polypeptide binding]; other site 1017264000960 ATP binding site [chemical binding]; other site 1017264000961 Rubredoxin [Energy production and conversion]; Region: COG1773 1017264000962 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1017264000963 iron binding site [ion binding]; other site 1017264000964 hypothetical protein; Validated; Region: PRK00228 1017264000965 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1017264000966 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1017264000967 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1017264000968 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1017264000969 dihydroorotase; Provisional; Region: PRK07627 1017264000970 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1017264000971 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1017264000972 active site 1017264000973 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1017264000974 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1017264000975 putative acyl-acceptor binding pocket; other site 1017264000976 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1017264000977 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1017264000978 active site 1017264000979 metal binding site [ion binding]; metal-binding site 1017264000980 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1017264000981 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1017264000982 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1017264000983 Transglycosylase; Region: Transgly; cl17702 1017264000984 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264000985 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264000986 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264000987 Integrase core domain; Region: rve; pfam00665 1017264000988 Integrase core domain; Region: rve_3; pfam13683 1017264000989 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1017264000990 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1017264000991 acyl-activating enzyme (AAE) consensus motif; other site 1017264000992 putative AMP binding site [chemical binding]; other site 1017264000993 putative active site [active] 1017264000994 putative CoA binding site [chemical binding]; other site 1017264000995 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264000996 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1017264000997 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1017264000998 DUF35 OB-fold domain; Region: DUF35; pfam01796 1017264000999 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 1017264001000 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1017264001001 active site 1017264001002 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1017264001003 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001004 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1017264001005 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1017264001006 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1017264001007 metal binding site [ion binding]; metal-binding site 1017264001008 active site 1017264001009 I-site; other site 1017264001010 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1017264001011 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1017264001012 DNA binding site [nucleotide binding] 1017264001013 active site 1017264001014 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1017264001015 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1017264001016 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1017264001017 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1017264001018 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1017264001019 Walker A/P-loop; other site 1017264001020 ATP binding site [chemical binding]; other site 1017264001021 Q-loop/lid; other site 1017264001022 ABC transporter signature motif; other site 1017264001023 Walker B; other site 1017264001024 D-loop; other site 1017264001025 H-loop/switch region; other site 1017264001026 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1017264001027 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1017264001028 ABC-ATPase subunit interface; other site 1017264001029 dimer interface [polypeptide binding]; other site 1017264001030 putative PBP binding regions; other site 1017264001031 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1017264001032 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1017264001033 intersubunit interface [polypeptide binding]; other site 1017264001034 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1017264001035 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1017264001036 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1017264001037 Secretin and TonB N terminus short domain; Region: STN; smart00965 1017264001038 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1017264001039 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264001040 N-terminal plug; other site 1017264001041 ligand-binding site [chemical binding]; other site 1017264001042 fec operon regulator FecR; Reviewed; Region: PRK09774 1017264001043 FecR protein; Region: FecR; pfam04773 1017264001044 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1017264001045 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1017264001046 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1017264001047 DNA binding residues [nucleotide binding] 1017264001048 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1017264001049 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264001050 catalytic loop [active] 1017264001051 iron binding site [ion binding]; other site 1017264001052 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1017264001053 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264001054 catalytic loop [active] 1017264001055 iron binding site [ion binding]; other site 1017264001056 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1017264001057 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1017264001058 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001059 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001060 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001061 Integrase core domain; Region: rve; pfam00665 1017264001062 Integrase core domain; Region: rve_3; pfam13683 1017264001063 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1017264001064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264001065 DNA-binding site [nucleotide binding]; DNA binding site 1017264001066 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1017264001067 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1017264001068 SepZ; Region: SepZ; pfam06066 1017264001069 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1017264001070 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1017264001071 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1017264001072 NAD(P) binding site [chemical binding]; other site 1017264001073 catalytic residues [active] 1017264001074 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1017264001075 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1017264001076 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264001077 catalytic loop [active] 1017264001078 iron binding site [ion binding]; other site 1017264001079 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1017264001080 FAD binding pocket [chemical binding]; other site 1017264001081 FAD binding motif [chemical binding]; other site 1017264001082 phosphate binding motif [ion binding]; other site 1017264001083 beta-alpha-beta structure motif; other site 1017264001084 NAD binding pocket [chemical binding]; other site 1017264001085 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1017264001086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264001087 substrate binding pocket [chemical binding]; other site 1017264001088 membrane-bound complex binding site; other site 1017264001089 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1017264001090 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1017264001091 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1017264001092 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001093 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001094 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001095 Integrase core domain; Region: rve; pfam00665 1017264001096 Integrase core domain; Region: rve_3; pfam13683 1017264001097 Predicted membrane protein [Function unknown]; Region: COG2860 1017264001098 UPF0126 domain; Region: UPF0126; pfam03458 1017264001099 UPF0126 domain; Region: UPF0126; pfam03458 1017264001100 glutamate dehydrogenase; Provisional; Region: PRK09414 1017264001101 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1017264001102 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1017264001103 NAD(P) binding site [chemical binding]; other site 1017264001104 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1017264001105 putative active site [active] 1017264001106 putative catalytic site [active] 1017264001107 putative DNA binding site [nucleotide binding]; other site 1017264001108 putative phosphate binding site [ion binding]; other site 1017264001109 metal binding site A [ion binding]; metal-binding site 1017264001110 putative AP binding site [nucleotide binding]; other site 1017264001111 putative metal binding site B [ion binding]; other site 1017264001112 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1017264001113 active site 1017264001114 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1017264001115 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1017264001116 GatB domain; Region: GatB_Yqey; smart00845 1017264001117 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1017264001118 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1017264001119 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1017264001120 rod shape-determining protein MreB; Provisional; Region: PRK13927 1017264001121 MreB and similar proteins; Region: MreB_like; cd10225 1017264001122 nucleotide binding site [chemical binding]; other site 1017264001123 Mg binding site [ion binding]; other site 1017264001124 putative protofilament interaction site [polypeptide binding]; other site 1017264001125 RodZ interaction site [polypeptide binding]; other site 1017264001126 rod shape-determining protein MreC; Provisional; Region: PRK13922 1017264001127 rod shape-determining protein MreC; Region: MreC; pfam04085 1017264001128 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1017264001129 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1017264001130 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1017264001131 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1017264001132 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1017264001133 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1017264001134 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1017264001135 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1017264001136 transmembrane helices; other site 1017264001137 division inhibitor protein; Provisional; Region: slmA; PRK09480 1017264001138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264001139 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1017264001140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1017264001141 motif II; other site 1017264001142 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1017264001143 feedback inhibition sensing region; other site 1017264001144 homohexameric interface [polypeptide binding]; other site 1017264001145 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1017264001146 nucleotide binding site [chemical binding]; other site 1017264001147 N-acetyl-L-glutamate binding site [chemical binding]; other site 1017264001148 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1017264001149 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1017264001150 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1017264001151 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1017264001152 catalytic residues [active] 1017264001153 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1017264001154 BON domain; Region: BON; pfam04972 1017264001155 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1017264001156 active site 1017264001157 dimer interface [polypeptide binding]; other site 1017264001158 Predicted methyltransferases [General function prediction only]; Region: COG0313 1017264001159 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1017264001160 putative SAM binding site [chemical binding]; other site 1017264001161 putative homodimer interface [polypeptide binding]; other site 1017264001162 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1017264001163 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1017264001164 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1017264001165 DNA binding site [nucleotide binding] 1017264001166 active site 1017264001167 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001168 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001169 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001170 Integrase core domain; Region: rve; pfam00665 1017264001171 Integrase core domain; Region: rve_3; pfam13683 1017264001172 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 1017264001173 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1017264001174 catalytic residues [active] 1017264001175 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264001176 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264001177 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001178 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264001179 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264001180 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1017264001181 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264001182 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1017264001183 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264001184 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001185 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001186 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001187 Integrase core domain; Region: rve; pfam00665 1017264001188 Integrase core domain; Region: rve_3; pfam13683 1017264001189 thioredoxin reductase; Provisional; Region: PRK10262 1017264001190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1017264001191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1017264001192 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001193 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001194 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001195 Integrase core domain; Region: rve; pfam00665 1017264001196 Integrase core domain; Region: rve_3; pfam13683 1017264001197 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001198 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1017264001199 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264001200 substrate binding site [chemical binding]; other site 1017264001201 oxyanion hole (OAH) forming residues; other site 1017264001202 trimer interface [polypeptide binding]; other site 1017264001203 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264001204 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264001205 hypothetical protein; Provisional; Region: PRK06154 1017264001206 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1017264001207 PYR/PP interface [polypeptide binding]; other site 1017264001208 dimer interface [polypeptide binding]; other site 1017264001209 TPP binding site [chemical binding]; other site 1017264001210 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1017264001211 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1017264001212 TPP-binding site; other site 1017264001213 dimer interface [polypeptide binding]; other site 1017264001214 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264001215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264001216 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1017264001217 putative dimerization interface [polypeptide binding]; other site 1017264001218 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1017264001219 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1017264001220 active site residue [active] 1017264001221 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1017264001222 active site residue [active] 1017264001223 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 1017264001224 active site residue [active] 1017264001225 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001226 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1017264001227 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001228 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001229 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001230 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001231 Integrase core domain; Region: rve; pfam00665 1017264001232 Integrase core domain; Region: rve_3; pfam13683 1017264001233 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1017264001234 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1017264001235 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1017264001236 Predicted membrane protein [Function unknown]; Region: COG4125 1017264001237 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1017264001238 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1017264001239 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 1017264001240 putative active site [active] 1017264001241 YdjC motif; other site 1017264001242 Mg binding site [ion binding]; other site 1017264001243 putative homodimer interface [polypeptide binding]; other site 1017264001244 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1017264001245 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1017264001246 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1017264001247 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1017264001248 Ligand binding site; other site 1017264001249 Putative Catalytic site; other site 1017264001250 DXD motif; other site 1017264001251 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1017264001252 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1017264001253 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1017264001254 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1017264001255 active site 1017264001256 catalytic site [active] 1017264001257 substrate binding site [chemical binding]; other site 1017264001258 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001259 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001260 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001261 Integrase core domain; Region: rve; pfam00665 1017264001262 Integrase core domain; Region: rve_3; pfam13683 1017264001263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1017264001264 Ligand Binding Site [chemical binding]; other site 1017264001265 Putative phosphatase (DUF442); Region: DUF442; cl17385 1017264001266 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1017264001267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264001268 DNA-binding site [nucleotide binding]; DNA binding site 1017264001269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264001270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264001271 homodimer interface [polypeptide binding]; other site 1017264001272 catalytic residue [active] 1017264001273 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1017264001274 MgtC family; Region: MgtC; pfam02308 1017264001275 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1017264001276 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264001277 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264001278 enoyl-CoA hydratase; Provisional; Region: PRK09245 1017264001279 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264001280 substrate binding site [chemical binding]; other site 1017264001281 oxyanion hole (OAH) forming residues; other site 1017264001282 trimer interface [polypeptide binding]; other site 1017264001283 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001284 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1017264001285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264001286 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1017264001287 dimerization interface [polypeptide binding]; other site 1017264001288 substrate binding pocket [chemical binding]; other site 1017264001289 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1017264001290 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1017264001291 active site 1017264001292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1017264001293 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1017264001294 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1017264001295 dimer interface [polypeptide binding]; other site 1017264001296 active site 1017264001297 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001298 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001299 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001300 Integrase core domain; Region: rve; pfam00665 1017264001301 Integrase core domain; Region: rve_3; pfam13683 1017264001302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264001303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264001304 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1017264001305 putative dimerization interface [polypeptide binding]; other site 1017264001306 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1017264001307 DNA-binding site [nucleotide binding]; DNA binding site 1017264001308 RNA-binding motif; other site 1017264001309 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1017264001310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264001311 DNA-binding site [nucleotide binding]; DNA binding site 1017264001312 FCD domain; Region: FCD; pfam07729 1017264001313 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1017264001314 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1017264001315 Glutamate binding site [chemical binding]; other site 1017264001316 NAD binding site [chemical binding]; other site 1017264001317 catalytic residues [active] 1017264001318 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1017264001319 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1017264001320 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1017264001321 molybdopterin cofactor binding site; other site 1017264001322 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1017264001323 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1017264001324 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 1017264001325 putative molybdopterin cofactor binding site; other site 1017264001326 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1017264001327 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1017264001328 FAD binding pocket [chemical binding]; other site 1017264001329 FAD binding motif [chemical binding]; other site 1017264001330 phosphate binding motif [ion binding]; other site 1017264001331 beta-alpha-beta structure motif; other site 1017264001332 NAD binding pocket [chemical binding]; other site 1017264001333 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264001334 catalytic loop [active] 1017264001335 iron binding site [ion binding]; other site 1017264001336 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1017264001337 homotrimer interaction site [polypeptide binding]; other site 1017264001338 putative active site [active] 1017264001339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264001340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264001341 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1017264001342 putative effector binding pocket; other site 1017264001343 putative dimerization interface [polypeptide binding]; other site 1017264001344 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 1017264001345 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264001346 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1017264001347 putative active site [active] 1017264001348 putative catalytic site [active] 1017264001349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264001350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264001351 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1017264001352 putative dimerization interface [polypeptide binding]; other site 1017264001353 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264001354 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264001355 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001356 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001357 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001358 Integrase core domain; Region: rve; pfam00665 1017264001359 Integrase core domain; Region: rve_3; pfam13683 1017264001360 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1017264001361 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1017264001362 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1017264001363 Moco binding site; other site 1017264001364 metal coordination site [ion binding]; other site 1017264001365 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1017264001366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1017264001367 motif II; other site 1017264001368 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1017264001369 S4 domain; Region: S4; pfam01479 1017264001370 RNA binding surface [nucleotide binding]; other site 1017264001371 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1017264001372 active site 1017264001373 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1017264001374 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1017264001375 homodimer interface [polypeptide binding]; other site 1017264001376 oligonucleotide binding site [chemical binding]; other site 1017264001377 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 1017264001378 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1017264001379 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK00014 1017264001380 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1017264001381 Proteins containing SET domain [General function prediction only]; Region: COG2940 1017264001382 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 1017264001383 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1017264001384 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1017264001385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264001386 putative DNA binding site [nucleotide binding]; other site 1017264001387 putative Zn2+ binding site [ion binding]; other site 1017264001388 AsnC family; Region: AsnC_trans_reg; pfam01037 1017264001389 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 1017264001390 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1017264001391 PYR/PP interface [polypeptide binding]; other site 1017264001392 dimer interface [polypeptide binding]; other site 1017264001393 TPP binding site [chemical binding]; other site 1017264001394 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1017264001395 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1017264001396 TPP-binding site [chemical binding]; other site 1017264001397 dimer interface [polypeptide binding]; other site 1017264001398 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 1017264001399 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1017264001400 putative NAD(P) binding site [chemical binding]; other site 1017264001401 active site 1017264001402 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1017264001403 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 1017264001404 NAD(P) binding site [chemical binding]; other site 1017264001405 catalytic residues [active] 1017264001406 catalytic residues [active] 1017264001407 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 1017264001408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264001409 NAD(P) binding site [chemical binding]; other site 1017264001410 active site 1017264001411 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264001412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264001413 dimer interface [polypeptide binding]; other site 1017264001414 conserved gate region; other site 1017264001415 putative PBP binding loops; other site 1017264001416 ABC-ATPase subunit interface; other site 1017264001417 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1017264001418 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1017264001419 Walker A/P-loop; other site 1017264001420 ATP binding site [chemical binding]; other site 1017264001421 Q-loop/lid; other site 1017264001422 ABC transporter signature motif; other site 1017264001423 Walker B; other site 1017264001424 D-loop; other site 1017264001425 H-loop/switch region; other site 1017264001426 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1017264001427 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1017264001428 DNA topoisomerase III; Validated; Region: PRK08173 1017264001429 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1017264001430 active site 1017264001431 putative interdomain interaction site [polypeptide binding]; other site 1017264001432 putative metal-binding site [ion binding]; other site 1017264001433 putative nucleotide binding site [chemical binding]; other site 1017264001434 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1017264001435 domain I; other site 1017264001436 DNA binding groove [nucleotide binding] 1017264001437 phosphate binding site [ion binding]; other site 1017264001438 domain II; other site 1017264001439 domain III; other site 1017264001440 nucleotide binding site [chemical binding]; other site 1017264001441 catalytic site [active] 1017264001442 domain IV; other site 1017264001443 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1017264001444 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1017264001445 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 1017264001446 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 1017264001447 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1017264001448 Protein of unknown function (DUF494); Region: DUF494; pfam04361 1017264001449 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1017264001450 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264001451 N-terminal plug; other site 1017264001452 ligand-binding site [chemical binding]; other site 1017264001453 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1017264001454 DctM-like transporters; Region: DctM; pfam06808 1017264001455 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1017264001456 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1017264001457 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1017264001458 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 1017264001459 dimer interface [polypeptide binding]; other site 1017264001460 active site 1017264001461 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1017264001462 substrate binding site [chemical binding]; other site 1017264001463 catalytic residue [active] 1017264001464 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001465 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 1017264001466 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1017264001467 inhibitor-cofactor binding pocket; inhibition site 1017264001468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264001469 catalytic residue [active] 1017264001470 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1017264001471 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1017264001472 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1017264001473 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1017264001474 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1017264001475 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1017264001476 carboxyltransferase (CT) interaction site; other site 1017264001477 biotinylation site [posttranslational modification]; other site 1017264001478 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1017264001479 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1017264001480 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1017264001481 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1017264001482 dimer interface [polypeptide binding]; other site 1017264001483 active site 1017264001484 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001485 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001486 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001487 Integrase core domain; Region: rve; pfam00665 1017264001488 Integrase core domain; Region: rve_3; pfam13683 1017264001489 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1017264001490 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1017264001491 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1017264001492 DNA binding residues [nucleotide binding] 1017264001493 putative dimer interface [polypeptide binding]; other site 1017264001494 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001495 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001496 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001497 Integrase core domain; Region: rve; pfam00665 1017264001498 Integrase core domain; Region: rve_3; pfam13683 1017264001499 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1017264001500 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1017264001501 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1017264001502 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1017264001503 active site 1017264001504 substrate binding site [chemical binding]; other site 1017264001505 FMN binding site [chemical binding]; other site 1017264001506 putative catalytic residues [active] 1017264001507 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001508 amidase; Provisional; Region: PRK07486 1017264001509 Amidase; Region: Amidase; pfam01425 1017264001510 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1017264001511 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1017264001512 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264001513 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1017264001514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264001515 ATP binding site [chemical binding]; other site 1017264001516 Mg2+ binding site [ion binding]; other site 1017264001517 G-X-G motif; other site 1017264001518 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1017264001519 anchoring element; other site 1017264001520 dimer interface [polypeptide binding]; other site 1017264001521 ATP binding site [chemical binding]; other site 1017264001522 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1017264001523 active site 1017264001524 putative metal-binding site [ion binding]; other site 1017264001525 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1017264001526 DNA polymerase III subunit beta; Validated; Region: PRK05643 1017264001527 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1017264001528 putative DNA binding surface [nucleotide binding]; other site 1017264001529 dimer interface [polypeptide binding]; other site 1017264001530 beta-clamp/clamp loader binding surface; other site 1017264001531 beta-clamp/translesion DNA polymerase binding surface; other site 1017264001532 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1017264001533 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1017264001534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264001535 Walker A motif; other site 1017264001536 ATP binding site [chemical binding]; other site 1017264001537 Walker B motif; other site 1017264001538 arginine finger; other site 1017264001539 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1017264001540 DnaA box-binding interface [nucleotide binding]; other site 1017264001541 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1017264001542 ribonuclease P; Reviewed; Region: rnpA; PRK00038 1017264001543 Haemolytic domain; Region: Haemolytic; pfam01809 1017264001544 membrane protein insertase; Provisional; Region: PRK01318 1017264001545 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1017264001546 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001547 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001548 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001549 Integrase core domain; Region: rve; pfam00665 1017264001550 Integrase core domain; Region: rve_3; pfam13683 1017264001551 LysR family transcriptional regulator; Provisional; Region: PRK14997 1017264001552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264001553 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1017264001554 putative effector binding pocket; other site 1017264001555 putative dimerization interface [polypeptide binding]; other site 1017264001556 Tir chaperone protein (CesT) family; Region: CesT; cl08444 1017264001557 Protein of unknown function (DUF3120); Region: DUF3220; pfam11516 1017264001558 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1017264001559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1017264001560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264001561 dimer interface [polypeptide binding]; other site 1017264001562 phosphorylation site [posttranslational modification] 1017264001563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264001564 ATP binding site [chemical binding]; other site 1017264001565 Mg2+ binding site [ion binding]; other site 1017264001566 G-X-G motif; other site 1017264001567 integrase; Provisional; Region: int; PHA02601 1017264001568 Rci recombinase, C-terminal catalytic domain. Rci enzymes are found in IncI1 incompatibility group plasmids such as R64. These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796 1017264001569 catalytic residues [active] 1017264001570 Int/Topo IB signature motif; other site 1017264001571 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1017264001572 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1017264001573 RecT family; Region: RecT; pfam03837 1017264001574 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001575 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001576 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001577 Integrase core domain; Region: rve; pfam00665 1017264001578 Integrase core domain; Region: rve_3; pfam13683 1017264001579 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1017264001580 homotrimer interaction site [polypeptide binding]; other site 1017264001581 putative active site [active] 1017264001582 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 1017264001583 GSH binding site (G-site) [chemical binding]; other site 1017264001584 C-terminal domain interface [polypeptide binding]; other site 1017264001585 dimer interface [polypeptide binding]; other site 1017264001586 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 1017264001587 dimer interface [polypeptide binding]; other site 1017264001588 N-terminal domain interface [polypeptide binding]; other site 1017264001589 substrate binding pocket (H-site) [chemical binding]; other site 1017264001590 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1017264001591 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1017264001592 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1017264001593 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1017264001594 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 1017264001595 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1017264001596 dimer interface [polypeptide binding]; other site 1017264001597 active site 1017264001598 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1017264001599 substrate binding site [chemical binding]; other site 1017264001600 catalytic residue [active] 1017264001601 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1017264001602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1017264001603 motif II; other site 1017264001604 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1017264001605 Predicted small secreted protein [Function unknown]; Region: COG5510 1017264001606 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1017264001607 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1017264001608 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1017264001609 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1017264001610 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1017264001611 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1017264001612 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1017264001613 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1017264001614 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1017264001615 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1017264001616 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1017264001617 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1017264001618 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1017264001619 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 1017264001620 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001621 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1017264001622 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1017264001623 acyl-activating enzyme (AAE) consensus motif; other site 1017264001624 AMP binding site [chemical binding]; other site 1017264001625 active site 1017264001626 CoA binding site [chemical binding]; other site 1017264001627 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264001628 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1017264001629 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264001630 enoyl-CoA hydratase; Provisional; Region: PRK08140 1017264001631 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264001632 substrate binding site [chemical binding]; other site 1017264001633 oxyanion hole (OAH) forming residues; other site 1017264001634 trimer interface [polypeptide binding]; other site 1017264001635 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1017264001636 Arginase family; Region: Arginase; cd09989 1017264001637 active site 1017264001638 Mn binding site [ion binding]; other site 1017264001639 oligomer interface [polypeptide binding]; other site 1017264001640 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 1017264001641 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1017264001642 inhibitor-cofactor binding pocket; inhibition site 1017264001643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264001644 catalytic residue [active] 1017264001645 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001646 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001647 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001648 Integrase core domain; Region: rve; pfam00665 1017264001649 Integrase core domain; Region: rve_3; pfam13683 1017264001650 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1017264001651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264001652 DNA-binding site [nucleotide binding]; DNA binding site 1017264001653 FCD domain; Region: FCD; pfam07729 1017264001654 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001655 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1017264001656 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1017264001657 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 1017264001658 active site 1 [active] 1017264001659 dimer interface [polypeptide binding]; other site 1017264001660 hexamer interface [polypeptide binding]; other site 1017264001661 active site 2 [active] 1017264001662 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1017264001663 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1017264001664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1017264001665 FeS/SAM binding site; other site 1017264001666 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1017264001667 Ferritin-like domain; Region: Ferritin; pfam00210 1017264001668 dinuclear metal binding motif [ion binding]; other site 1017264001669 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1017264001670 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1017264001671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1017264001672 motif II; other site 1017264001673 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1017264001674 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1017264001675 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1017264001676 putative active site [active] 1017264001677 substrate binding site [chemical binding]; other site 1017264001678 putative cosubstrate binding site; other site 1017264001679 catalytic site [active] 1017264001680 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1017264001681 substrate binding site [chemical binding]; other site 1017264001682 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1017264001683 active site 1017264001684 catalytic residues [active] 1017264001685 metal binding site [ion binding]; metal-binding site 1017264001686 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 1017264001687 kynureninase; Region: kynureninase; TIGR01814 1017264001688 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1017264001689 catalytic residue [active] 1017264001690 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1017264001691 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264001692 putative DNA binding site [nucleotide binding]; other site 1017264001693 putative Zn2+ binding site [ion binding]; other site 1017264001694 AsnC family; Region: AsnC_trans_reg; pfam01037 1017264001695 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1017264001696 DNA protecting protein DprA; Region: dprA; TIGR00732 1017264001697 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1017264001698 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1017264001699 active site 1017264001700 catalytic residues [active] 1017264001701 metal binding site [ion binding]; metal-binding site 1017264001702 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1017264001703 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1017264001704 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264001705 substrate binding pocket [chemical binding]; other site 1017264001706 membrane-bound complex binding site; other site 1017264001707 hinge residues; other site 1017264001708 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264001709 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1017264001710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264001711 homodimer interface [polypeptide binding]; other site 1017264001712 catalytic residue [active] 1017264001713 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001714 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1017264001715 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1017264001716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264001717 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264001718 dimerization interface [polypeptide binding]; other site 1017264001719 LysE type translocator; Region: LysE; cl00565 1017264001720 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001721 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001722 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001723 Integrase core domain; Region: rve; pfam00665 1017264001724 Integrase core domain; Region: rve_3; pfam13683 1017264001725 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1017264001726 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1017264001727 L-aspartate dehydrogenase; Provisional; Region: PRK13303 1017264001728 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1017264001729 Domain of unknown function DUF108; Region: DUF108; pfam01958 1017264001730 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1017264001731 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1017264001732 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1017264001733 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1017264001734 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 1017264001735 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 1017264001736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1017264001737 dimerization interface [polypeptide binding]; other site 1017264001738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264001739 dimer interface [polypeptide binding]; other site 1017264001740 phosphorylation site [posttranslational modification] 1017264001741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264001742 ATP binding site [chemical binding]; other site 1017264001743 Mg2+ binding site [ion binding]; other site 1017264001744 G-X-G motif; other site 1017264001745 Response regulator receiver domain; Region: Response_reg; pfam00072 1017264001746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264001747 active site 1017264001748 phosphorylation site [posttranslational modification] 1017264001749 intermolecular recognition site; other site 1017264001750 dimerization interface [polypeptide binding]; other site 1017264001751 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1017264001752 TrkA-N domain; Region: TrkA_N; pfam02254 1017264001753 TrkA-C domain; Region: TrkA_C; pfam02080 1017264001754 TrkA-N domain; Region: TrkA_N; pfam02254 1017264001755 TrkA-C domain; Region: TrkA_C; pfam02080 1017264001756 Cation transport protein; Region: TrkH; cl17365 1017264001757 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1017264001758 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1017264001759 MarR family; Region: MarR_2; pfam12802 1017264001760 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1017264001761 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1017264001762 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1017264001763 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1017264001764 Ligand binding site; other site 1017264001765 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1017264001766 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1017264001767 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1017264001768 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1017264001769 Isochorismatase family; Region: Isochorismatase; pfam00857 1017264001770 catalytic triad [active] 1017264001771 conserved cis-peptide bond; other site 1017264001772 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1017264001773 inter-subunit interface; other site 1017264001774 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1017264001775 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1017264001776 iron-sulfur cluster [ion binding]; other site 1017264001777 [2Fe-2S] cluster binding site [ion binding]; other site 1017264001778 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 1017264001779 putative alpha subunit interface [polypeptide binding]; other site 1017264001780 putative active site [active] 1017264001781 putative substrate binding site [chemical binding]; other site 1017264001782 Fe binding site [ion binding]; other site 1017264001783 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1017264001784 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1017264001785 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1017264001786 [2Fe-2S] cluster binding site [ion binding]; other site 1017264001787 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1017264001788 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1017264001789 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1017264001790 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1017264001791 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1017264001792 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1017264001793 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1017264001794 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264001795 catalytic loop [active] 1017264001796 iron binding site [ion binding]; other site 1017264001797 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1017264001798 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1017264001799 putative hydrophobic ligand binding site [chemical binding]; other site 1017264001800 NMT1/THI5 like; Region: NMT1; pfam09084 1017264001801 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1017264001802 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1017264001803 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1017264001804 Walker A/P-loop; other site 1017264001805 ATP binding site [chemical binding]; other site 1017264001806 Q-loop/lid; other site 1017264001807 ABC transporter signature motif; other site 1017264001808 Walker B; other site 1017264001809 D-loop; other site 1017264001810 H-loop/switch region; other site 1017264001811 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264001812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264001813 ABC-ATPase subunit interface; other site 1017264001814 putative PBP binding loops; other site 1017264001815 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 1017264001816 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1017264001817 DctM-like transporters; Region: DctM; pfam06808 1017264001818 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1017264001819 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1017264001820 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1017264001821 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1017264001822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264001823 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1017264001824 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1017264001825 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1017264001826 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1017264001827 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1017264001828 preprotein translocase subunit SecB; Validated; Region: PRK05751 1017264001829 SecA binding site; other site 1017264001830 Preprotein binding site; other site 1017264001831 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1017264001832 GSH binding site [chemical binding]; other site 1017264001833 catalytic residues [active] 1017264001834 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1017264001835 active site residue [active] 1017264001836 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1017264001837 catalytic core [active] 1017264001838 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1017264001839 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1017264001840 Peptidase family M23; Region: Peptidase_M23; pfam01551 1017264001841 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1017264001842 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1017264001843 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1017264001844 protein binding site [polypeptide binding]; other site 1017264001845 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1017264001846 Catalytic dyad [active] 1017264001847 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1017264001848 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1017264001849 ATP binding site [chemical binding]; other site 1017264001850 substrate interface [chemical binding]; other site 1017264001851 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001852 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001853 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001854 Integrase core domain; Region: rve; pfam00665 1017264001855 Integrase core domain; Region: rve_3; pfam13683 1017264001856 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001857 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1017264001858 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264001859 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264001860 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001861 Amidohydrolase; Region: Amidohydro_2; pfam04909 1017264001862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264001863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264001864 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1017264001865 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1017264001866 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1017264001867 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1017264001868 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1017264001869 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1017264001870 Walker A/P-loop; other site 1017264001871 ATP binding site [chemical binding]; other site 1017264001872 Q-loop/lid; other site 1017264001873 ABC transporter signature motif; other site 1017264001874 Walker B; other site 1017264001875 D-loop; other site 1017264001876 H-loop/switch region; other site 1017264001877 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1017264001878 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1017264001879 TM-ABC transporter signature motif; other site 1017264001880 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1017264001881 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264001882 Walker A/P-loop; other site 1017264001883 ATP binding site [chemical binding]; other site 1017264001884 Q-loop/lid; other site 1017264001885 ABC transporter signature motif; other site 1017264001886 Walker B; other site 1017264001887 D-loop; other site 1017264001888 H-loop/switch region; other site 1017264001889 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1017264001890 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264001891 TM-ABC transporter signature motif; other site 1017264001892 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1017264001893 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1017264001894 acyl-CoA synthetase; Validated; Region: PRK06145 1017264001895 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1017264001896 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1017264001897 acyl-activating enzyme (AAE) consensus motif; other site 1017264001898 acyl-activating enzyme (AAE) consensus motif; other site 1017264001899 putative AMP binding site [chemical binding]; other site 1017264001900 putative active site [active] 1017264001901 putative CoA binding site [chemical binding]; other site 1017264001902 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1017264001903 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1017264001904 active site 1017264001905 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1017264001906 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264001907 substrate binding site [chemical binding]; other site 1017264001908 oxyanion hole (OAH) forming residues; other site 1017264001909 trimer interface [polypeptide binding]; other site 1017264001910 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1017264001911 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1017264001912 alpha subunit interface [polypeptide binding]; other site 1017264001913 TPP binding site [chemical binding]; other site 1017264001914 heterodimer interface [polypeptide binding]; other site 1017264001915 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1017264001916 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1017264001917 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1017264001918 tetramer interface [polypeptide binding]; other site 1017264001919 TPP-binding site [chemical binding]; other site 1017264001920 heterodimer interface [polypeptide binding]; other site 1017264001921 phosphorylation loop region [posttranslational modification] 1017264001922 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264001923 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1017264001924 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264001925 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001926 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1017264001927 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1017264001928 active site 1017264001929 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1017264001930 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264001931 substrate binding site [chemical binding]; other site 1017264001932 oxyanion hole (OAH) forming residues; other site 1017264001933 trimer interface [polypeptide binding]; other site 1017264001934 thiolase; Provisional; Region: PRK06158 1017264001935 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1017264001936 active site 1017264001937 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1017264001938 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1017264001939 DUF35 OB-fold domain; Region: DUF35; pfam01796 1017264001940 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1017264001941 active site 2 [active] 1017264001942 active site 1 [active] 1017264001943 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1017264001944 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1017264001945 active site 1017264001946 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001947 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264001948 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264001949 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1017264001950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264001951 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1017264001952 putative dimerization interface [polypeptide binding]; other site 1017264001953 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1017264001954 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1017264001955 inhibitor site; inhibition site 1017264001956 active site 1017264001957 dimer interface [polypeptide binding]; other site 1017264001958 catalytic residue [active] 1017264001959 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001960 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001961 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001962 Integrase core domain; Region: rve; pfam00665 1017264001963 Integrase core domain; Region: rve_3; pfam13683 1017264001964 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264001965 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264001966 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264001967 Integrase core domain; Region: rve; pfam00665 1017264001968 Integrase core domain; Region: rve_3; pfam13683 1017264001969 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 1017264001970 substrate binding site [chemical binding]; other site 1017264001971 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001972 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1017264001973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264001974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264001975 dimerization interface [polypeptide binding]; other site 1017264001976 D-lactate dehydrogenase; Provisional; Region: PRK11183 1017264001977 FAD binding domain; Region: FAD_binding_4; pfam01565 1017264001978 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1017264001979 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1017264001980 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1017264001981 active site 1017264001982 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1017264001983 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1017264001984 FAD binding site [chemical binding]; other site 1017264001985 substrate binding site [chemical binding]; other site 1017264001986 catalytic base [active] 1017264001987 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264001988 acetylornithine deacetylase; Provisional; Region: PRK07522 1017264001989 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1017264001990 metal binding site [ion binding]; metal-binding site 1017264001991 putative dimer interface [polypeptide binding]; other site 1017264001992 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1017264001993 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1017264001994 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1017264001995 homotrimer interaction site [polypeptide binding]; other site 1017264001996 putative active site [active] 1017264001997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1017264001998 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1017264001999 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1017264002000 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1017264002001 NADP binding site [chemical binding]; other site 1017264002002 dimer interface [polypeptide binding]; other site 1017264002003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264002004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264002005 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1017264002006 putative substrate binding pocket [chemical binding]; other site 1017264002007 dimerization interface [polypeptide binding]; other site 1017264002008 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1017264002009 CoA binding domain; Region: CoA_binding_2; pfam13380 1017264002010 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1017264002011 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1017264002012 enoyl-CoA hydratase; Provisional; Region: PRK07658 1017264002013 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264002014 substrate binding site [chemical binding]; other site 1017264002015 oxyanion hole (OAH) forming residues; other site 1017264002016 trimer interface [polypeptide binding]; other site 1017264002017 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1017264002018 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1017264002019 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264002020 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1017264002021 extended (e) SDRs; Region: SDR_e; cd08946 1017264002022 NAD(P) binding site [chemical binding]; other site 1017264002023 active site 1017264002024 substrate binding site [chemical binding]; other site 1017264002025 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1017264002026 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1017264002027 glutaminase active site [active] 1017264002028 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1017264002029 dimer interface [polypeptide binding]; other site 1017264002030 active site 1017264002031 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1017264002032 dimer interface [polypeptide binding]; other site 1017264002033 active site 1017264002034 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1017264002035 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264002036 putative DNA binding site [nucleotide binding]; other site 1017264002037 putative Zn2+ binding site [ion binding]; other site 1017264002038 AsnC family; Region: AsnC_trans_reg; pfam01037 1017264002039 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1017264002040 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1017264002041 dimer interface [polypeptide binding]; other site 1017264002042 active site 1017264002043 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1017264002044 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264002045 substrate binding site [chemical binding]; other site 1017264002046 oxyanion hole (OAH) forming residues; other site 1017264002047 trimer interface [polypeptide binding]; other site 1017264002048 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1017264002049 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1017264002050 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1017264002051 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1017264002052 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1017264002053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1017264002054 FAD binding site [chemical binding]; other site 1017264002055 substrate binding site [chemical binding]; other site 1017264002056 catalytic residues [active] 1017264002057 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264002058 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1017264002059 CoA binding domain; Region: CoA_binding_2; pfam13380 1017264002060 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1017264002061 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1017264002062 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1017264002063 active site 1017264002064 oxalacetate binding site [chemical binding]; other site 1017264002065 citrylCoA binding site [chemical binding]; other site 1017264002066 coenzyme A binding site [chemical binding]; other site 1017264002067 catalytic triad [active] 1017264002068 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1017264002069 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264002070 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264002071 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1017264002072 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1017264002073 molybdopterin cofactor binding site [chemical binding]; other site 1017264002074 substrate binding site [chemical binding]; other site 1017264002075 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1017264002076 molybdopterin cofactor binding site; other site 1017264002077 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002078 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002079 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002080 Integrase core domain; Region: rve; pfam00665 1017264002081 Integrase core domain; Region: rve_3; pfam13683 1017264002082 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1017264002083 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1017264002084 tRNA; other site 1017264002085 putative tRNA binding site [nucleotide binding]; other site 1017264002086 putative NADP binding site [chemical binding]; other site 1017264002087 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1017264002088 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1017264002089 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1017264002090 RF-1 domain; Region: RF-1; pfam00472 1017264002091 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1017264002092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264002093 S-adenosylmethionine binding site [chemical binding]; other site 1017264002094 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1017264002095 putative GSH binding site [chemical binding]; other site 1017264002096 catalytic residues [active] 1017264002097 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1017264002098 Flavoprotein; Region: Flavoprotein; pfam02441 1017264002099 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264002100 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1017264002101 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1017264002102 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1017264002103 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1017264002104 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1017264002105 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1017264002106 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1017264002107 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002108 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002109 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002110 Integrase core domain; Region: rve; pfam00665 1017264002111 Integrase core domain; Region: rve_3; pfam13683 1017264002112 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1017264002113 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1017264002114 Sporulation related domain; Region: SPOR; pfam05036 1017264002115 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1017264002116 AAA domain; Region: AAA_18; pfam13238 1017264002117 Cytochrome c; Region: Cytochrom_C; pfam00034 1017264002118 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1017264002119 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1017264002120 Cytochrome c; Region: Cytochrom_C; pfam00034 1017264002121 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1017264002122 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1017264002123 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1017264002124 Hpr binding site; other site 1017264002125 active site 1017264002126 homohexamer subunit interaction site [polypeptide binding]; other site 1017264002127 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1017264002128 active site 1017264002129 phosphorylation site [posttranslational modification] 1017264002130 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1017264002131 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1017264002132 Walker A/P-loop; other site 1017264002133 ATP binding site [chemical binding]; other site 1017264002134 Q-loop/lid; other site 1017264002135 ABC transporter signature motif; other site 1017264002136 Walker B; other site 1017264002137 D-loop; other site 1017264002138 H-loop/switch region; other site 1017264002139 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1017264002140 OstA-like protein; Region: OstA; pfam03968 1017264002141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 1017264002142 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1017264002143 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1017264002144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1017264002145 active site 1017264002146 motif I; other site 1017264002147 motif II; other site 1017264002148 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1017264002149 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1017264002150 putative active site [active] 1017264002151 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1017264002152 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1017264002153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264002154 ATP-grasp domain; Region: ATP-grasp; pfam02222 1017264002155 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002156 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002157 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002158 Integrase core domain; Region: rve; pfam00665 1017264002159 Integrase core domain; Region: rve_3; pfam13683 1017264002160 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 1017264002161 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1017264002162 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1017264002163 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1017264002164 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1017264002165 dimer interface [polypeptide binding]; other site 1017264002166 anticodon binding site; other site 1017264002167 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1017264002168 homodimer interface [polypeptide binding]; other site 1017264002169 motif 1; other site 1017264002170 active site 1017264002171 motif 2; other site 1017264002172 GAD domain; Region: GAD; pfam02938 1017264002173 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1017264002174 motif 3; other site 1017264002175 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1017264002176 putative catalytic site [active] 1017264002177 putative metal binding site [ion binding]; other site 1017264002178 putative phosphate binding site [ion binding]; other site 1017264002179 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1017264002180 PLD-like domain; Region: PLDc_2; pfam13091 1017264002181 putative active site [active] 1017264002182 catalytic site [active] 1017264002183 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1017264002184 PLD-like domain; Region: PLDc_2; pfam13091 1017264002185 putative active site [active] 1017264002186 catalytic site [active] 1017264002187 EamA-like transporter family; Region: EamA; pfam00892 1017264002188 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1017264002189 EamA-like transporter family; Region: EamA; pfam00892 1017264002190 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1017264002191 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1017264002192 tetramer interface [polypeptide binding]; other site 1017264002193 active site 1017264002194 Mg2+/Mn2+ binding site [ion binding]; other site 1017264002195 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 1017264002196 aminotransferase; Validated; Region: PRK07678 1017264002197 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1017264002198 inhibitor-cofactor binding pocket; inhibition site 1017264002199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264002200 catalytic residue [active] 1017264002201 amidase; Provisional; Region: PRK07487 1017264002202 Amidase; Region: Amidase; cl11426 1017264002203 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1017264002204 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264002205 Walker A/P-loop; other site 1017264002206 ATP binding site [chemical binding]; other site 1017264002207 Q-loop/lid; other site 1017264002208 ABC transporter signature motif; other site 1017264002209 Walker B; other site 1017264002210 D-loop; other site 1017264002211 H-loop/switch region; other site 1017264002212 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1017264002213 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264002214 Walker A/P-loop; other site 1017264002215 ATP binding site [chemical binding]; other site 1017264002216 Q-loop/lid; other site 1017264002217 ABC transporter signature motif; other site 1017264002218 Walker B; other site 1017264002219 D-loop; other site 1017264002220 H-loop/switch region; other site 1017264002221 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1017264002222 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1017264002223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264002224 dimer interface [polypeptide binding]; other site 1017264002225 conserved gate region; other site 1017264002226 putative PBP binding loops; other site 1017264002227 ABC-ATPase subunit interface; other site 1017264002228 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1017264002229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264002230 dimer interface [polypeptide binding]; other site 1017264002231 conserved gate region; other site 1017264002232 putative PBP binding loops; other site 1017264002233 ABC-ATPase subunit interface; other site 1017264002234 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1017264002235 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1017264002236 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1017264002237 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264002238 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264002239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264002240 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002241 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002242 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002243 Integrase core domain; Region: rve; pfam00665 1017264002244 Integrase core domain; Region: rve_3; pfam13683 1017264002245 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1017264002246 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1017264002247 dimer interface [polypeptide binding]; other site 1017264002248 active site 1017264002249 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1017264002250 catalytic residues [active] 1017264002251 substrate binding site [chemical binding]; other site 1017264002252 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1017264002253 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1017264002254 NAD(P) binding pocket [chemical binding]; other site 1017264002255 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002256 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002257 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002258 Integrase core domain; Region: rve; pfam00665 1017264002259 Integrase core domain; Region: rve_3; pfam13683 1017264002260 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1017264002261 Secretin and TonB N terminus short domain; Region: STN; smart00965 1017264002262 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1017264002263 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264002264 N-terminal plug; other site 1017264002265 ligand-binding site [chemical binding]; other site 1017264002266 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1017264002267 FecR protein; Region: FecR; pfam04773 1017264002268 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002269 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002270 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002271 Integrase core domain; Region: rve; pfam00665 1017264002272 Integrase core domain; Region: rve_3; pfam13683 1017264002273 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1017264002274 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1017264002275 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1017264002276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1017264002277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1017264002278 non-specific DNA binding site [nucleotide binding]; other site 1017264002279 salt bridge; other site 1017264002280 sequence-specific DNA binding site [nucleotide binding]; other site 1017264002281 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1017264002282 non-specific DNA binding site [nucleotide binding]; other site 1017264002283 salt bridge; other site 1017264002284 sequence-specific DNA binding site [nucleotide binding]; other site 1017264002285 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1017264002286 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1017264002287 DNA binding site [nucleotide binding] 1017264002288 gamma-glutamyl kinase; Provisional; Region: PRK05429 1017264002289 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1017264002290 nucleotide binding site [chemical binding]; other site 1017264002291 homotetrameric interface [polypeptide binding]; other site 1017264002292 putative phosphate binding site [ion binding]; other site 1017264002293 putative allosteric binding site; other site 1017264002294 PUA domain; Region: PUA; pfam01472 1017264002295 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1017264002296 GTP1/OBG; Region: GTP1_OBG; pfam01018 1017264002297 Obg GTPase; Region: Obg; cd01898 1017264002298 G1 box; other site 1017264002299 GTP/Mg2+ binding site [chemical binding]; other site 1017264002300 Switch I region; other site 1017264002301 G2 box; other site 1017264002302 G3 box; other site 1017264002303 Switch II region; other site 1017264002304 G4 box; other site 1017264002305 G5 box; other site 1017264002306 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1017264002307 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1017264002308 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1017264002309 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 1017264002310 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1017264002311 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1017264002312 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1017264002313 substrate binding pocket [chemical binding]; other site 1017264002314 chain length determination region; other site 1017264002315 substrate-Mg2+ binding site; other site 1017264002316 catalytic residues [active] 1017264002317 aspartate-rich region 1; other site 1017264002318 active site lid residues [active] 1017264002319 aspartate-rich region 2; other site 1017264002320 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1017264002321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264002322 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264002323 dimerization interface [polypeptide binding]; other site 1017264002324 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1017264002325 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1017264002326 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1017264002327 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1017264002328 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1017264002329 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1017264002330 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1017264002331 succinic semialdehyde dehydrogenase; Region: PLN02278 1017264002332 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1017264002333 tetramerization interface [polypeptide binding]; other site 1017264002334 NAD(P) binding site [chemical binding]; other site 1017264002335 catalytic residues [active] 1017264002336 RTX toxin acyltransferase family; Region: HlyC; pfam02794 1017264002337 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 1017264002338 RTX N-terminal domain; Region: RTX; pfam02382 1017264002339 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 1017264002340 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1017264002341 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1017264002342 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 1017264002343 Walker A/P-loop; other site 1017264002344 ATP binding site [chemical binding]; other site 1017264002345 Q-loop/lid; other site 1017264002346 ABC transporter signature motif; other site 1017264002347 Walker B; other site 1017264002348 D-loop; other site 1017264002349 H-loop/switch region; other site 1017264002350 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1017264002351 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1017264002352 HlyD family secretion protein; Region: HlyD_3; pfam13437 1017264002353 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1017264002354 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264002355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264002356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1017264002357 dimerization interface [polypeptide binding]; other site 1017264002358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264002359 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1017264002360 substrate binding pocket [chemical binding]; other site 1017264002361 membrane-bound complex binding site; other site 1017264002362 hinge residues; other site 1017264002363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1017264002364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264002365 putative PBP binding loops; other site 1017264002366 ABC-ATPase subunit interface; other site 1017264002367 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1017264002368 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1017264002369 Walker A/P-loop; other site 1017264002370 ATP binding site [chemical binding]; other site 1017264002371 Q-loop/lid; other site 1017264002372 ABC transporter signature motif; other site 1017264002373 Walker B; other site 1017264002374 D-loop; other site 1017264002375 H-loop/switch region; other site 1017264002376 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1017264002377 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1017264002378 homodimer interface [polypeptide binding]; other site 1017264002379 substrate-cofactor binding pocket; other site 1017264002380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264002381 catalytic residue [active] 1017264002382 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264002383 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 1017264002384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264002385 NAD(P) binding site [chemical binding]; other site 1017264002386 active site 1017264002387 acetolactate synthase catalytic subunit; Validated; Region: PRK06112 1017264002388 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1017264002389 PYR/PP interface [polypeptide binding]; other site 1017264002390 dimer interface [polypeptide binding]; other site 1017264002391 TPP binding site [chemical binding]; other site 1017264002392 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1017264002393 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1017264002394 TPP-binding site [chemical binding]; other site 1017264002395 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1017264002396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264002397 DNA-binding site [nucleotide binding]; DNA binding site 1017264002398 FCD domain; Region: FCD; pfam07729 1017264002399 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1017264002400 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1017264002401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264002402 DNA-binding site [nucleotide binding]; DNA binding site 1017264002403 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1017264002404 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1017264002405 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1017264002406 NAD(P) binding site [chemical binding]; other site 1017264002407 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1017264002408 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1017264002409 acyl-activating enzyme (AAE) consensus motif; other site 1017264002410 AMP binding site [chemical binding]; other site 1017264002411 active site 1017264002412 CoA binding site [chemical binding]; other site 1017264002413 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 1017264002414 putative active site [active] 1017264002415 Zn binding site [ion binding]; other site 1017264002416 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264002417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264002418 dimer interface [polypeptide binding]; other site 1017264002419 conserved gate region; other site 1017264002420 putative PBP binding loops; other site 1017264002421 ABC-ATPase subunit interface; other site 1017264002422 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1017264002423 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1017264002424 Walker A/P-loop; other site 1017264002425 ATP binding site [chemical binding]; other site 1017264002426 Q-loop/lid; other site 1017264002427 ABC transporter signature motif; other site 1017264002428 Walker B; other site 1017264002429 D-loop; other site 1017264002430 H-loop/switch region; other site 1017264002431 NMT1/THI5 like; Region: NMT1; pfam09084 1017264002432 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1017264002433 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1017264002434 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1017264002435 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1017264002436 PYR/PP interface [polypeptide binding]; other site 1017264002437 dimer interface [polypeptide binding]; other site 1017264002438 TPP binding site [chemical binding]; other site 1017264002439 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1017264002440 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1017264002441 TPP-binding site [chemical binding]; other site 1017264002442 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1017264002443 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1017264002444 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002445 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002446 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002447 Integrase core domain; Region: rve; pfam00665 1017264002448 Integrase core domain; Region: rve_3; pfam13683 1017264002449 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 1017264002450 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1017264002451 PYR/PP interface [polypeptide binding]; other site 1017264002452 dimer interface [polypeptide binding]; other site 1017264002453 TPP binding site [chemical binding]; other site 1017264002454 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1017264002455 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1017264002456 TPP-binding site [chemical binding]; other site 1017264002457 dimer interface [polypeptide binding]; other site 1017264002458 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1017264002459 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1017264002460 putative valine binding site [chemical binding]; other site 1017264002461 dimer interface [polypeptide binding]; other site 1017264002462 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1017264002463 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1017264002464 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1017264002465 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1017264002466 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1017264002467 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1017264002468 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1017264002469 16S/18S rRNA binding site [nucleotide binding]; other site 1017264002470 S13e-L30e interaction site [polypeptide binding]; other site 1017264002471 25S rRNA binding site [nucleotide binding]; other site 1017264002472 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1017264002473 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1017264002474 RNase E interface [polypeptide binding]; other site 1017264002475 trimer interface [polypeptide binding]; other site 1017264002476 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1017264002477 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1017264002478 RNase E interface [polypeptide binding]; other site 1017264002479 trimer interface [polypeptide binding]; other site 1017264002480 active site 1017264002481 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1017264002482 putative nucleic acid binding region [nucleotide binding]; other site 1017264002483 G-X-X-G motif; other site 1017264002484 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1017264002485 RNA binding site [nucleotide binding]; other site 1017264002486 domain interface; other site 1017264002487 threonine dehydratase; Provisional; Region: PRK07334 1017264002488 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1017264002489 tetramer interface [polypeptide binding]; other site 1017264002490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264002491 catalytic residue [active] 1017264002492 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1017264002493 PIN domain; Region: PIN_3; pfam13470 1017264002494 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1017264002495 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1017264002496 NAD(P) binding site [chemical binding]; other site 1017264002497 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1017264002498 triosephosphate isomerase; Provisional; Region: PRK14567 1017264002499 substrate binding site [chemical binding]; other site 1017264002500 dimer interface [polypeptide binding]; other site 1017264002501 catalytic triad [active] 1017264002502 protein translocase, SecG subunit; Region: secG; TIGR00810 1017264002503 BCCT family transporter; Region: BCCT; cl00569 1017264002504 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264002505 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1017264002506 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264002507 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 1017264002508 dimer interface [polypeptide binding]; other site 1017264002509 Methylaspartate ammonia-lyase C-terminus; Region: MAAL_C; pfam07476 1017264002510 active site 1017264002511 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264002512 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1017264002513 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264002514 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264002515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264002516 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264002517 short chain dehydrogenase; Provisional; Region: PRK08339 1017264002518 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1017264002519 putative NAD(P) binding site [chemical binding]; other site 1017264002520 putative active site [active] 1017264002521 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264002522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264002523 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1017264002524 putative dimerization interface [polypeptide binding]; other site 1017264002525 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1017264002526 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1017264002527 homodimer interface [polypeptide binding]; other site 1017264002528 substrate-cofactor binding pocket; other site 1017264002529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264002530 catalytic residue [active] 1017264002531 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_5; cd06255 1017264002532 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1017264002533 putative active site [active] 1017264002534 Zn binding site [ion binding]; other site 1017264002535 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264002536 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1017264002537 active site residue [active] 1017264002538 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1017264002539 active site residue [active] 1017264002540 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1017264002541 active site residue [active] 1017264002542 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1017264002543 active site residue [active] 1017264002544 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264002545 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1017264002546 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1017264002547 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1017264002548 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1017264002549 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1017264002550 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1017264002551 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1017264002552 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1017264002553 azurin; Region: azurin; TIGR02695 1017264002554 Predicted transcriptional regulator [Transcription]; Region: COG2345 1017264002555 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1017264002556 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1017264002557 multidrug efflux protein; Reviewed; Region: PRK09579 1017264002558 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1017264002559 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1017264002560 HlyD family secretion protein; Region: HlyD_3; pfam13437 1017264002561 Predicted transcriptional regulators [Transcription]; Region: COG1733 1017264002562 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1017264002563 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002564 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002565 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002566 Integrase core domain; Region: rve; pfam00665 1017264002567 Integrase core domain; Region: rve_3; pfam13683 1017264002568 BCCT family transporter; Region: BCCT; cl00569 1017264002569 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264002570 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264002571 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264002572 dimerization interface [polypeptide binding]; other site 1017264002573 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1017264002574 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1017264002575 active site 1017264002576 metal binding site [ion binding]; metal-binding site 1017264002577 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1017264002578 active site 1017264002579 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1017264002580 CoenzymeA binding site [chemical binding]; other site 1017264002581 subunit interaction site [polypeptide binding]; other site 1017264002582 PHB binding site; other site 1017264002583 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002584 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002585 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002586 Integrase core domain; Region: rve; pfam00665 1017264002587 Integrase core domain; Region: rve_3; pfam13683 1017264002588 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1017264002589 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1017264002590 trimer interface [polypeptide binding]; other site 1017264002591 eyelet of channel; other site 1017264002592 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1017264002593 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1017264002594 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1017264002595 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1017264002596 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1017264002597 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1017264002598 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1017264002599 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1017264002600 putative dimer interface [polypeptide binding]; other site 1017264002601 [2Fe-2S] cluster binding site [ion binding]; other site 1017264002602 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1017264002603 SLBB domain; Region: SLBB; pfam10531 1017264002604 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1017264002605 NADH dehydrogenase subunit G; Validated; Region: PRK09129 1017264002606 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264002607 catalytic loop [active] 1017264002608 iron binding site [ion binding]; other site 1017264002609 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1017264002610 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 1017264002611 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1017264002612 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1017264002613 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1017264002614 4Fe-4S binding domain; Region: Fer4; pfam00037 1017264002615 4Fe-4S binding domain; Region: Fer4; cl02805 1017264002616 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1017264002617 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1017264002618 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1017264002619 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1017264002620 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1017264002621 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1017264002622 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1017264002623 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1017264002624 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1017264002625 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 1017264002626 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1017264002627 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264002628 N-terminal plug; other site 1017264002629 ligand-binding site [chemical binding]; other site 1017264002630 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1017264002631 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264002632 N-terminal plug; other site 1017264002633 ligand-binding site [chemical binding]; other site 1017264002634 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1017264002635 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1017264002636 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1017264002637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264002638 NAD(P) binding site [chemical binding]; other site 1017264002639 active site 1017264002640 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1017264002641 acetolactate synthase catalytic subunit; Validated; Region: PRK06112 1017264002642 PYR/PP interface [polypeptide binding]; other site 1017264002643 dimer interface [polypeptide binding]; other site 1017264002644 TPP binding site [chemical binding]; other site 1017264002645 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1017264002646 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1017264002647 TPP-binding site [chemical binding]; other site 1017264002648 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264002649 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264002650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264002651 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1017264002652 putative dimerization interface [polypeptide binding]; other site 1017264002653 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1017264002654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1017264002655 motif II; other site 1017264002656 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1017264002657 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1017264002658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1017264002659 ATP binding site [chemical binding]; other site 1017264002660 putative Mg++ binding site [ion binding]; other site 1017264002661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1017264002662 nucleotide binding region [chemical binding]; other site 1017264002663 ATP-binding site [chemical binding]; other site 1017264002664 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1017264002665 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1017264002666 substrate binding site; other site 1017264002667 dimer interface; other site 1017264002668 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1017264002669 homotrimer interaction site [polypeptide binding]; other site 1017264002670 zinc binding site [ion binding]; other site 1017264002671 CDP-binding sites; other site 1017264002672 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002673 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002674 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002675 Integrase core domain; Region: rve; pfam00665 1017264002676 Integrase core domain; Region: rve_3; pfam13683 1017264002677 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1017264002678 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1017264002679 AMP binding site [chemical binding]; other site 1017264002680 metal binding site [ion binding]; metal-binding site 1017264002681 active site 1017264002682 aminopeptidase N; Provisional; Region: pepN; PRK14015 1017264002683 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1017264002684 active site 1017264002685 Zn binding site [ion binding]; other site 1017264002686 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1017264002687 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002688 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002689 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002690 Integrase core domain; Region: rve; pfam00665 1017264002691 Integrase core domain; Region: rve_3; pfam13683 1017264002692 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1017264002693 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1017264002694 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1017264002695 Walker A/P-loop; other site 1017264002696 ATP binding site [chemical binding]; other site 1017264002697 Q-loop/lid; other site 1017264002698 ABC transporter signature motif; other site 1017264002699 Walker B; other site 1017264002700 D-loop; other site 1017264002701 H-loop/switch region; other site 1017264002702 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 1017264002703 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1017264002704 Flagellar regulator YcgR; Region: YcgR; pfam07317 1017264002705 PilZ domain; Region: PilZ; pfam07238 1017264002706 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1017264002707 dimerization interface [polypeptide binding]; other site 1017264002708 substrate binding site [chemical binding]; other site 1017264002709 active site 1017264002710 calcium binding site [ion binding]; other site 1017264002711 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1017264002712 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1017264002713 carboxyltransferase (CT) interaction site; other site 1017264002714 biotinylation site [posttranslational modification]; other site 1017264002715 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 1017264002716 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1017264002717 active site 1017264002718 catalytic residues [active] 1017264002719 metal binding site [ion binding]; metal-binding site 1017264002720 homodimer binding site [polypeptide binding]; other site 1017264002721 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1017264002722 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1017264002723 NAD(P) binding site [chemical binding]; other site 1017264002724 active site 1017264002725 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1017264002726 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264002727 DNA-binding site [nucleotide binding]; DNA binding site 1017264002728 UTRA domain; Region: UTRA; pfam07702 1017264002729 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1017264002730 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1017264002731 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1017264002732 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1017264002733 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002734 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002735 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002736 Integrase core domain; Region: rve; pfam00665 1017264002737 Integrase core domain; Region: rve_3; pfam13683 1017264002738 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1017264002739 dimerization interface [polypeptide binding]; other site 1017264002740 putative active cleft [active] 1017264002741 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002742 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002743 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002744 Integrase core domain; Region: rve; pfam00665 1017264002745 Integrase core domain; Region: rve_3; pfam13683 1017264002746 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1017264002747 iron-sulfur cluster [ion binding]; other site 1017264002748 [2Fe-2S] cluster binding site [ion binding]; other site 1017264002749 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1017264002750 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1017264002751 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 1017264002752 Walker A/P-loop; other site 1017264002753 ATP binding site [chemical binding]; other site 1017264002754 Q-loop/lid; other site 1017264002755 ABC transporter signature motif; other site 1017264002756 Walker B; other site 1017264002757 D-loop; other site 1017264002758 H-loop/switch region; other site 1017264002759 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1017264002760 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1017264002761 active site 1017264002762 catalytic tetrad [active] 1017264002763 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1017264002764 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1017264002765 active site 1017264002766 catalytic tetrad [active] 1017264002767 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1017264002768 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1017264002769 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1017264002770 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1017264002771 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1017264002772 active site 1017264002773 metal binding site [ion binding]; metal-binding site 1017264002774 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1017264002775 Transglycosylase; Region: Transgly; pfam00912 1017264002776 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1017264002777 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1017264002778 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1017264002779 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1017264002780 CoenzymeA binding site [chemical binding]; other site 1017264002781 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1017264002782 subunit interaction site [polypeptide binding]; other site 1017264002783 PHB binding site; other site 1017264002784 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1017264002785 active site 1017264002786 DNA polymerase IV; Validated; Region: PRK02406 1017264002787 DNA binding site [nucleotide binding] 1017264002788 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002789 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002790 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002791 Integrase core domain; Region: rve; pfam00665 1017264002792 Integrase core domain; Region: rve_3; pfam13683 1017264002793 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1017264002794 PYR/PP interface [polypeptide binding]; other site 1017264002795 dimer interface [polypeptide binding]; other site 1017264002796 TPP binding site [chemical binding]; other site 1017264002797 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1017264002798 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1017264002799 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264002800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264002801 dimer interface [polypeptide binding]; other site 1017264002802 conserved gate region; other site 1017264002803 putative PBP binding loops; other site 1017264002804 ABC-ATPase subunit interface; other site 1017264002805 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264002806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264002807 dimer interface [polypeptide binding]; other site 1017264002808 conserved gate region; other site 1017264002809 putative PBP binding loops; other site 1017264002810 ABC-ATPase subunit interface; other site 1017264002811 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1017264002812 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1017264002813 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1017264002814 NAD(P) binding site [chemical binding]; other site 1017264002815 catalytic residues [active] 1017264002816 tricarballylate dehydrogenase; Validated; Region: PRK08274 1017264002817 tricarballylate utilization protein B; Provisional; Region: PRK15033 1017264002818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1017264002819 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 1017264002820 Predicted transcriptional regulators [Transcription]; Region: COG1378 1017264002821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264002822 dimerization interface [polypeptide binding]; other site 1017264002823 putative Zn2+ binding site [ion binding]; other site 1017264002824 putative DNA binding site [nucleotide binding]; other site 1017264002825 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1017264002826 C-terminal domain interface [polypeptide binding]; other site 1017264002827 sugar binding site [chemical binding]; other site 1017264002828 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1017264002829 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1017264002830 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1017264002831 active site 1017264002832 iron coordination sites [ion binding]; other site 1017264002833 substrate binding pocket [chemical binding]; other site 1017264002834 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264002835 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264002836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264002837 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264002838 dimerization interface [polypeptide binding]; other site 1017264002839 Restriction endonuclease; Region: Mrr_cat; pfam04471 1017264002840 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1017264002841 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1017264002842 acyl-activating enzyme (AAE) consensus motif; other site 1017264002843 putative AMP binding site [chemical binding]; other site 1017264002844 putative active site [active] 1017264002845 putative CoA binding site [chemical binding]; other site 1017264002846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1017264002847 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1017264002848 DUF35 OB-fold domain; Region: DUF35; pfam01796 1017264002849 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264002850 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264002851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264002852 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1017264002853 dimerization interface [polypeptide binding]; other site 1017264002854 substrate binding pocket [chemical binding]; other site 1017264002855 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1017264002856 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1017264002857 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002858 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002859 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002860 Integrase core domain; Region: rve; pfam00665 1017264002861 Integrase core domain; Region: rve_3; pfam13683 1017264002862 YcfA-like protein; Region: YcfA; pfam07927 1017264002863 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1017264002864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264002865 putative substrate translocation pore; other site 1017264002866 phosphoglycolate phosphatase; Provisional; Region: PRK13226 1017264002867 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1017264002868 motif II; other site 1017264002869 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1017264002870 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1017264002871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264002872 S-adenosylmethionine binding site [chemical binding]; other site 1017264002873 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1017264002874 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1017264002875 ligand binding site [chemical binding]; other site 1017264002876 DNA gyrase subunit A; Validated; Region: PRK05560 1017264002877 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1017264002878 CAP-like domain; other site 1017264002879 active site 1017264002880 primary dimer interface [polypeptide binding]; other site 1017264002881 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1017264002882 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1017264002883 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1017264002884 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1017264002885 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1017264002886 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1017264002887 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1017264002888 homodimer interface [polypeptide binding]; other site 1017264002889 substrate-cofactor binding pocket; other site 1017264002890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264002891 catalytic residue [active] 1017264002892 Chorismate mutase type II; Region: CM_2; cl00693 1017264002893 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1017264002894 Prephenate dehydratase; Region: PDT; pfam00800 1017264002895 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1017264002896 putative L-Phe binding site [chemical binding]; other site 1017264002897 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1017264002898 prephenate dehydrogenase; Validated; Region: PRK08507 1017264002899 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1017264002900 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1017264002901 hinge; other site 1017264002902 active site 1017264002903 cytidylate kinase; Provisional; Region: cmk; PRK00023 1017264002904 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1017264002905 CMP-binding site; other site 1017264002906 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1017264002907 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1017264002908 RNA binding site [nucleotide binding]; other site 1017264002909 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1017264002910 RNA binding site [nucleotide binding]; other site 1017264002911 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1017264002912 RNA binding site [nucleotide binding]; other site 1017264002913 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1017264002914 RNA binding site [nucleotide binding]; other site 1017264002915 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1017264002916 RNA binding site [nucleotide binding]; other site 1017264002917 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1017264002918 RNA binding site [nucleotide binding]; other site 1017264002919 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1017264002920 IHF - DNA interface [nucleotide binding]; other site 1017264002921 IHF dimer interface [polypeptide binding]; other site 1017264002922 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1017264002923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1017264002924 binding surface 1017264002925 TPR motif; other site 1017264002926 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1017264002927 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1017264002928 putative ribose interaction site [chemical binding]; other site 1017264002929 putative ADP binding site [chemical binding]; other site 1017264002930 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1017264002931 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1017264002932 NADP binding site [chemical binding]; other site 1017264002933 homopentamer interface [polypeptide binding]; other site 1017264002934 substrate binding site [chemical binding]; other site 1017264002935 active site 1017264002936 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1017264002937 Helix-hairpin-helix motif; Region: HHH; pfam00633 1017264002938 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264002939 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264002940 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264002941 Integrase core domain; Region: rve; pfam00665 1017264002942 Integrase core domain; Region: rve_3; pfam13683 1017264002943 cysteine synthase B; Region: cysM; TIGR01138 1017264002944 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1017264002945 dimer interface [polypeptide binding]; other site 1017264002946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264002947 catalytic residue [active] 1017264002948 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1017264002949 NIL domain; Region: NIL; cl09633 1017264002950 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1017264002951 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1017264002952 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1017264002953 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1017264002954 putative active site [active] 1017264002955 Zn binding site [ion binding]; other site 1017264002956 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1017264002957 Ligand binding site [chemical binding]; other site 1017264002958 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1017264002959 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1017264002960 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1017264002961 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1017264002962 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1017264002963 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1017264002964 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1017264002965 active site 1017264002966 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1017264002967 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1017264002968 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1017264002969 dimer interface [polypeptide binding]; other site 1017264002970 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1017264002971 catalytic triad [active] 1017264002972 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1017264002973 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1017264002974 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1017264002975 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1017264002976 Walker A/P-loop; other site 1017264002977 ATP binding site [chemical binding]; other site 1017264002978 Q-loop/lid; other site 1017264002979 ABC transporter signature motif; other site 1017264002980 Walker B; other site 1017264002981 D-loop; other site 1017264002982 H-loop/switch region; other site 1017264002983 TOBE-like domain; Region: TOBE_3; pfam12857 1017264002984 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1017264002985 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1017264002986 Active Sites [active] 1017264002987 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1017264002988 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1017264002989 EamA-like transporter family; Region: EamA; cl17759 1017264002990 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1017264002991 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1017264002992 putative active site [active] 1017264002993 putative CoA binding site [chemical binding]; other site 1017264002994 nudix motif; other site 1017264002995 metal binding site [ion binding]; metal-binding site 1017264002996 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1017264002997 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1017264002998 active site 1017264002999 catalytic tetrad [active] 1017264003000 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264003001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264003002 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264003003 Chorismate lyase; Region: Chor_lyase; cl01230 1017264003004 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1017264003005 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1017264003006 RNA binding surface [nucleotide binding]; other site 1017264003007 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1017264003008 active site 1017264003009 transcriptional regulator; Provisional; Region: PRK10632 1017264003010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264003011 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1017264003012 putative effector binding pocket; other site 1017264003013 dimerization interface [polypeptide binding]; other site 1017264003014 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1017264003015 Protein export membrane protein; Region: SecD_SecF; cl14618 1017264003016 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1017264003017 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 1017264003018 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1017264003019 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1017264003020 Cu(I) binding site [ion binding]; other site 1017264003021 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1017264003022 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1017264003023 active site 1017264003024 Zn binding site [ion binding]; other site 1017264003025 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 1017264003026 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1017264003027 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1017264003028 homodimer interface [polypeptide binding]; other site 1017264003029 NADP binding site [chemical binding]; other site 1017264003030 substrate binding site [chemical binding]; other site 1017264003031 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1017264003032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264003033 active site 1017264003034 phosphorylation site [posttranslational modification] 1017264003035 intermolecular recognition site; other site 1017264003036 dimerization interface [polypeptide binding]; other site 1017264003037 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1017264003038 DNA binding residues [nucleotide binding] 1017264003039 dimerization interface [polypeptide binding]; other site 1017264003040 PAS domain S-box; Region: sensory_box; TIGR00229 1017264003041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1017264003042 putative active site [active] 1017264003043 heme pocket [chemical binding]; other site 1017264003044 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1017264003045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264003046 dimer interface [polypeptide binding]; other site 1017264003047 phosphorylation site [posttranslational modification] 1017264003048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264003049 ATP binding site [chemical binding]; other site 1017264003050 Mg2+ binding site [ion binding]; other site 1017264003051 G-X-G motif; other site 1017264003052 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1017264003053 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1017264003054 dimer interface [polypeptide binding]; other site 1017264003055 TPP-binding site [chemical binding]; other site 1017264003056 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1017264003057 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1017264003058 E3 interaction surface; other site 1017264003059 lipoyl attachment site [posttranslational modification]; other site 1017264003060 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1017264003061 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1017264003062 E3 interaction surface; other site 1017264003063 lipoyl attachment site [posttranslational modification]; other site 1017264003064 e3 binding domain; Region: E3_binding; pfam02817 1017264003065 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1017264003066 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1017264003067 E3 interaction surface; other site 1017264003068 lipoyl attachment site [posttranslational modification]; other site 1017264003069 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1017264003070 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1017264003071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1017264003072 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1017264003073 flagellin; Validated; Region: PRK06819 1017264003074 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1017264003075 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1017264003076 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003077 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003078 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003079 Integrase core domain; Region: rve; pfam00665 1017264003080 Integrase core domain; Region: rve_3; pfam13683 1017264003081 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1017264003082 RNA methyltransferase, RsmE family; Region: TIGR00046 1017264003083 transketolase; Reviewed; Region: PRK12753 1017264003084 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1017264003085 TPP-binding site [chemical binding]; other site 1017264003086 dimer interface [polypeptide binding]; other site 1017264003087 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1017264003088 PYR/PP interface [polypeptide binding]; other site 1017264003089 dimer interface [polypeptide binding]; other site 1017264003090 TPP binding site [chemical binding]; other site 1017264003091 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1017264003092 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1017264003093 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1017264003094 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1017264003095 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1017264003096 Phosphoglycerate kinase; Region: PGK; pfam00162 1017264003097 substrate binding site [chemical binding]; other site 1017264003098 hinge regions; other site 1017264003099 ADP binding site [chemical binding]; other site 1017264003100 catalytic site [active] 1017264003101 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 1017264003102 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1017264003103 NAD binding site [chemical binding]; other site 1017264003104 homotetramer interface [polypeptide binding]; other site 1017264003105 homodimer interface [polypeptide binding]; other site 1017264003106 substrate binding site [chemical binding]; other site 1017264003107 active site 1017264003108 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1017264003109 propionate/acetate kinase; Provisional; Region: PRK12379 1017264003110 phosphate acetyltransferase; Provisional; Region: PRK11890 1017264003111 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 1017264003112 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 1017264003113 glutathione S-transferase; Provisional; Region: PRK15113 1017264003114 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1017264003115 C-terminal domain interface [polypeptide binding]; other site 1017264003116 GSH binding site (G-site) [chemical binding]; other site 1017264003117 dimer interface [polypeptide binding]; other site 1017264003118 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1017264003119 N-terminal domain interface [polypeptide binding]; other site 1017264003120 DinB family; Region: DinB; cl17821 1017264003121 DinB superfamily; Region: DinB_2; pfam12867 1017264003122 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1017264003123 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1017264003124 Coenzyme A binding pocket [chemical binding]; other site 1017264003125 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 1017264003126 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1017264003127 HSP70 interaction site [polypeptide binding]; other site 1017264003128 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1017264003129 substrate binding site [polypeptide binding]; other site 1017264003130 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1017264003131 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1017264003132 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1017264003133 MPT binding site; other site 1017264003134 trimer interface [polypeptide binding]; other site 1017264003135 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1017264003136 Peptidase family M23; Region: Peptidase_M23; pfam01551 1017264003137 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1017264003138 rRNA binding site [nucleotide binding]; other site 1017264003139 predicted 30S ribosome binding site; other site 1017264003140 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003141 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003142 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003143 Integrase core domain; Region: rve; pfam00665 1017264003144 Integrase core domain; Region: rve_3; pfam13683 1017264003145 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1017264003146 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1017264003147 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1017264003148 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1017264003149 DNA binding residues [nucleotide binding] 1017264003150 transcriptional activator FlhD; Provisional; Region: PRK02909 1017264003151 transcriptional activator FlhC; Provisional; Region: PRK12722 1017264003152 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1017264003153 flagellar motor protein MotA; Validated; Region: PRK09110 1017264003154 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1017264003155 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1017264003156 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1017264003157 ligand binding site [chemical binding]; other site 1017264003158 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1017264003159 putative binding surface; other site 1017264003160 active site 1017264003161 CheY binding; Region: CheY-binding; pfam09078 1017264003162 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1017264003163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264003164 ATP binding site [chemical binding]; other site 1017264003165 Mg2+ binding site [ion binding]; other site 1017264003166 G-X-G motif; other site 1017264003167 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1017264003168 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1017264003169 putative CheA interaction surface; other site 1017264003170 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1017264003171 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1017264003172 dimer interface [polypeptide binding]; other site 1017264003173 ligand binding site [chemical binding]; other site 1017264003174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1017264003175 dimerization interface [polypeptide binding]; other site 1017264003176 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1017264003177 dimer interface [polypeptide binding]; other site 1017264003178 putative CheW interface [polypeptide binding]; other site 1017264003179 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1017264003180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264003181 active site 1017264003182 phosphorylation site [posttranslational modification] 1017264003183 intermolecular recognition site; other site 1017264003184 dimerization interface [polypeptide binding]; other site 1017264003185 CheB methylesterase; Region: CheB_methylest; pfam01339 1017264003186 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1017264003187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264003188 active site 1017264003189 phosphorylation site [posttranslational modification] 1017264003190 intermolecular recognition site; other site 1017264003191 dimerization interface [polypeptide binding]; other site 1017264003192 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1017264003193 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264003194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264003195 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264003196 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1017264003197 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1017264003198 active site 1017264003199 catalytic tetrad [active] 1017264003200 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1017264003201 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1017264003202 putative active site [active] 1017264003203 catalytic triad [active] 1017264003204 putative dimer interface [polypeptide binding]; other site 1017264003205 FOG: CBS domain [General function prediction only]; Region: COG0517 1017264003206 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1017264003207 Transporter associated domain; Region: CorC_HlyC; smart01091 1017264003208 metal-binding heat shock protein; Provisional; Region: PRK00016 1017264003209 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1017264003210 PhoH-like protein; Region: PhoH; pfam02562 1017264003211 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1017264003212 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1017264003213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1017264003214 FeS/SAM binding site; other site 1017264003215 TRAM domain; Region: TRAM; pfam01938 1017264003216 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264003217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264003218 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264003219 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1017264003220 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1017264003221 Protein export membrane protein; Region: SecD_SecF; pfam02355 1017264003222 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1017264003223 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1017264003224 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1017264003225 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 1017264003226 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1017264003227 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1017264003228 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003229 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003230 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003231 Integrase core domain; Region: rve; pfam00665 1017264003232 Integrase core domain; Region: rve_3; pfam13683 1017264003233 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1017264003234 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1017264003235 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1017264003236 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1017264003237 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1017264003238 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1017264003239 active site 1017264003240 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264003241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264003242 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264003243 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1017264003244 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1017264003245 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1017264003246 siroheme synthase; Provisional; Region: cysG; PRK10637 1017264003247 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1017264003248 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 1017264003249 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1017264003250 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1017264003251 active site 1017264003252 SAM binding site [chemical binding]; other site 1017264003253 homodimer interface [polypeptide binding]; other site 1017264003254 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1017264003255 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1017264003256 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1017264003257 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1017264003258 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1017264003259 catalytic residue [active] 1017264003260 aminotransferase; Validated; Region: PRK07337 1017264003261 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264003262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264003263 homodimer interface [polypeptide binding]; other site 1017264003264 catalytic residue [active] 1017264003265 malic enzyme; Reviewed; Region: PRK12861 1017264003266 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1017264003267 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1017264003268 putative NAD(P) binding site [chemical binding]; other site 1017264003269 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1017264003270 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1017264003271 putative RNAase interaction site [polypeptide binding]; other site 1017264003272 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003273 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003274 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003275 Integrase core domain; Region: rve; pfam00665 1017264003276 Integrase core domain; Region: rve_3; pfam13683 1017264003277 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1017264003278 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1017264003279 Walker A/P-loop; other site 1017264003280 ATP binding site [chemical binding]; other site 1017264003281 Q-loop/lid; other site 1017264003282 ABC transporter signature motif; other site 1017264003283 Walker B; other site 1017264003284 D-loop; other site 1017264003285 H-loop/switch region; other site 1017264003286 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1017264003287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264003288 dimer interface [polypeptide binding]; other site 1017264003289 conserved gate region; other site 1017264003290 putative PBP binding loops; other site 1017264003291 ABC-ATPase subunit interface; other site 1017264003292 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1017264003293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264003294 dimer interface [polypeptide binding]; other site 1017264003295 conserved gate region; other site 1017264003296 putative PBP binding loops; other site 1017264003297 ABC-ATPase subunit interface; other site 1017264003298 PBP superfamily domain; Region: PBP_like_2; cl17296 1017264003299 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 1017264003300 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1017264003301 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1017264003302 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1017264003303 putative active site [active] 1017264003304 catalytic site [active] 1017264003305 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1017264003306 putative domain interface [polypeptide binding]; other site 1017264003307 putative active site [active] 1017264003308 catalytic site [active] 1017264003309 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1017264003310 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1017264003311 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1017264003312 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1017264003313 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1017264003314 active site 1017264003315 substrate binding site [chemical binding]; other site 1017264003316 metal binding site [ion binding]; metal-binding site 1017264003317 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1017264003318 dihydropteroate synthase; Region: DHPS; TIGR01496 1017264003319 substrate binding pocket [chemical binding]; other site 1017264003320 dimer interface [polypeptide binding]; other site 1017264003321 inhibitor binding site; inhibition site 1017264003322 FtsH Extracellular; Region: FtsH_ext; pfam06480 1017264003323 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1017264003324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264003325 Walker A motif; other site 1017264003326 ATP binding site [chemical binding]; other site 1017264003327 Walker B motif; other site 1017264003328 arginine finger; other site 1017264003329 Peptidase family M41; Region: Peptidase_M41; pfam01434 1017264003330 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1017264003331 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1017264003332 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 1017264003333 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003334 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003335 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003336 Integrase core domain; Region: rve; pfam00665 1017264003337 Integrase core domain; Region: rve_3; pfam13683 1017264003338 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1017264003339 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1017264003340 putative active site [active] 1017264003341 putative substrate binding site [chemical binding]; other site 1017264003342 ATP binding site [chemical binding]; other site 1017264003343 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1017264003344 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1017264003345 FMN binding site [chemical binding]; other site 1017264003346 active site 1017264003347 catalytic residues [active] 1017264003348 substrate binding site [chemical binding]; other site 1017264003349 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003350 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003351 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003352 Integrase core domain; Region: rve; pfam00665 1017264003353 Integrase core domain; Region: rve_3; pfam13683 1017264003354 FOG: CBS domain [General function prediction only]; Region: COG0517 1017264003355 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625 1017264003356 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1017264003357 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 1017264003358 hypothetical protein; Validated; Region: PRK00029 1017264003359 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1017264003360 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1017264003361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264003362 active site 1017264003363 phosphorylation site [posttranslational modification] 1017264003364 intermolecular recognition site; other site 1017264003365 dimerization interface [polypeptide binding]; other site 1017264003366 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1017264003367 DNA binding site [nucleotide binding] 1017264003368 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1017264003369 metal binding site [ion binding]; metal-binding site 1017264003370 active site 1017264003371 I-site; other site 1017264003372 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1017264003373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1017264003374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264003375 dimer interface [polypeptide binding]; other site 1017264003376 phosphorylation site [posttranslational modification] 1017264003377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264003378 ATP binding site [chemical binding]; other site 1017264003379 Mg2+ binding site [ion binding]; other site 1017264003380 G-X-G motif; other site 1017264003381 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003382 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003383 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003384 Integrase core domain; Region: rve; pfam00665 1017264003385 Integrase core domain; Region: rve_3; pfam13683 1017264003386 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1017264003387 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264003388 Walker A/P-loop; other site 1017264003389 ATP binding site [chemical binding]; other site 1017264003390 Q-loop/lid; other site 1017264003391 ABC transporter signature motif; other site 1017264003392 Walker B; other site 1017264003393 D-loop; other site 1017264003394 H-loop/switch region; other site 1017264003395 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264003396 TM-ABC transporter signature motif; other site 1017264003397 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1017264003398 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1017264003399 putative ligand binding site [chemical binding]; other site 1017264003400 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1017264003401 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1017264003402 Walker A/P-loop; other site 1017264003403 ATP binding site [chemical binding]; other site 1017264003404 Q-loop/lid; other site 1017264003405 ABC transporter signature motif; other site 1017264003406 Walker B; other site 1017264003407 D-loop; other site 1017264003408 H-loop/switch region; other site 1017264003409 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1017264003410 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1017264003411 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1017264003412 acyl-activating enzyme (AAE) consensus motif; other site 1017264003413 putative AMP binding site [chemical binding]; other site 1017264003414 putative active site [active] 1017264003415 putative CoA binding site [chemical binding]; other site 1017264003416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264003417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264003418 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1017264003419 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1017264003420 dimer interface [polypeptide binding]; other site 1017264003421 putative anticodon binding site; other site 1017264003422 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1017264003423 motif 1; other site 1017264003424 active site 1017264003425 motif 2; other site 1017264003426 motif 3; other site 1017264003427 short chain dehydrogenase; Provisional; Region: PRK07023 1017264003428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264003429 NAD(P) binding site [chemical binding]; other site 1017264003430 active site 1017264003431 peptide chain release factor 2; Provisional; Region: PRK08787 1017264003432 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1017264003433 RF-1 domain; Region: RF-1; pfam00472 1017264003434 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1017264003435 DHH family; Region: DHH; pfam01368 1017264003436 DHHA1 domain; Region: DHHA1; pfam02272 1017264003437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 1017264003438 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1017264003439 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1017264003440 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1017264003441 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1017264003442 Walker A/P-loop; other site 1017264003443 ATP binding site [chemical binding]; other site 1017264003444 Q-loop/lid; other site 1017264003445 ABC transporter signature motif; other site 1017264003446 Walker B; other site 1017264003447 D-loop; other site 1017264003448 H-loop/switch region; other site 1017264003449 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1017264003450 active site 1017264003451 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 1017264003452 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1017264003453 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003454 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003455 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003456 Integrase core domain; Region: rve; pfam00665 1017264003457 Integrase core domain; Region: rve_3; pfam13683 1017264003458 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1017264003459 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1017264003460 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1017264003461 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1017264003462 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1017264003463 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1017264003464 active site 1017264003465 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1017264003466 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1017264003467 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1017264003468 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1017264003469 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003470 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003471 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003472 Integrase core domain; Region: rve; pfam00665 1017264003473 Integrase core domain; Region: rve_3; pfam13683 1017264003474 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1017264003475 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1017264003476 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1017264003477 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1017264003478 putative NAD(P) binding site [chemical binding]; other site 1017264003479 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1017264003480 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 1017264003481 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1017264003482 dimer interface [polypeptide binding]; other site 1017264003483 TPP-binding site [chemical binding]; other site 1017264003484 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1017264003485 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1017264003486 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1017264003487 putative DNA binding site [nucleotide binding]; other site 1017264003488 putative Zn2+ binding site [ion binding]; other site 1017264003489 AsnC family; Region: AsnC_trans_reg; pfam01037 1017264003490 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1017264003491 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1017264003492 TPP-binding site [chemical binding]; other site 1017264003493 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1017264003494 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1017264003495 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1017264003496 E3 interaction surface; other site 1017264003497 lipoyl attachment site [posttranslational modification]; other site 1017264003498 e3 binding domain; Region: E3_binding; pfam02817 1017264003499 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1017264003500 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1017264003501 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1017264003502 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1017264003503 Predicted ATPase [General function prediction only]; Region: COG1485 1017264003504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264003505 Walker B; other site 1017264003506 D-loop; other site 1017264003507 H-loop/switch region; other site 1017264003508 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1017264003509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264003510 NAD(P) binding site [chemical binding]; other site 1017264003511 active site 1017264003512 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1017264003513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264003514 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1017264003515 dimerization interface [polypeptide binding]; other site 1017264003516 substrate binding pocket [chemical binding]; other site 1017264003517 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003518 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003519 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003520 Integrase core domain; Region: rve; pfam00665 1017264003521 Integrase core domain; Region: rve_3; pfam13683 1017264003522 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264003523 short chain dehydrogenase; Provisional; Region: PRK07577 1017264003524 classical (c) SDRs; Region: SDR_c; cd05233 1017264003525 NAD(P) binding site [chemical binding]; other site 1017264003526 active site 1017264003527 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003528 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003529 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003530 Integrase core domain; Region: rve; pfam00665 1017264003531 Integrase core domain; Region: rve_3; pfam13683 1017264003532 RNA polymerase sigma factor; Provisional; Region: PRK12528 1017264003533 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1017264003534 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1017264003535 DNA binding residues [nucleotide binding] 1017264003536 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1017264003537 FecR protein; Region: FecR; pfam04773 1017264003538 Secretin and TonB N terminus short domain; Region: STN; smart00965 1017264003539 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1017264003540 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264003541 N-terminal plug; other site 1017264003542 ligand-binding site [chemical binding]; other site 1017264003543 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1017264003544 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003545 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003546 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003547 Integrase core domain; Region: rve; pfam00665 1017264003548 Integrase core domain; Region: rve_3; pfam13683 1017264003549 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 1017264003550 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1017264003551 active site 1017264003552 HIGH motif; other site 1017264003553 dimer interface [polypeptide binding]; other site 1017264003554 KMSKS motif; other site 1017264003555 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1017264003556 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1017264003557 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1017264003558 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1017264003559 RNA binding site [nucleotide binding]; other site 1017264003560 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1017264003561 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1017264003562 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1017264003563 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1017264003564 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1017264003565 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1017264003566 RNA binding surface [nucleotide binding]; other site 1017264003567 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1017264003568 active site 1017264003569 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1017264003570 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1017264003571 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1017264003572 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1017264003573 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1017264003574 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1017264003575 NAD(P) binding site [chemical binding]; other site 1017264003576 homotetramer interface [polypeptide binding]; other site 1017264003577 homodimer interface [polypeptide binding]; other site 1017264003578 active site 1017264003579 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 1017264003580 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1017264003581 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1017264003582 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1017264003583 Fe2+ transport protein; Region: Iron_transport; pfam10634 1017264003584 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1017264003585 Iron permease FTR1 family; Region: FTR1; cl00475 1017264003586 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1017264003587 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1017264003588 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003589 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003590 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003591 Integrase core domain; Region: rve; pfam00665 1017264003592 Integrase core domain; Region: rve_3; pfam13683 1017264003593 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1017264003594 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1017264003595 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1017264003596 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1017264003597 active site 1017264003598 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264003599 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1017264003600 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1017264003601 active site pocket [active] 1017264003602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264003603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264003604 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 1017264003605 putative dimerization interface [polypeptide binding]; other site 1017264003606 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1017264003607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264003608 NAD(P) binding site [chemical binding]; other site 1017264003609 active site 1017264003610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264003611 putative substrate translocation pore; other site 1017264003612 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 1017264003613 Na binding site [ion binding]; other site 1017264003614 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1017264003615 dimer interface [polypeptide binding]; other site 1017264003616 catalytic triad [active] 1017264003617 hypothetical protein; Provisional; Region: PRK06486 1017264003618 intersubunit interface [polypeptide binding]; other site 1017264003619 active site 1017264003620 Zn2+ binding site [ion binding]; other site 1017264003621 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1017264003622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264003623 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1017264003624 putative dimerization interface [polypeptide binding]; other site 1017264003625 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1017264003626 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1017264003627 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264003628 Amino acid synthesis; Region: AA_synth; pfam06684 1017264003629 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 1017264003630 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1017264003631 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily; Region: M14_ASTE_ASPA_like; cd06230 1017264003632 active site 1017264003633 Zn binding site [ion binding]; other site 1017264003634 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003635 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003636 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003637 Integrase core domain; Region: rve; pfam00665 1017264003638 Integrase core domain; Region: rve_3; pfam13683 1017264003639 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1017264003640 EamA-like transporter family; Region: EamA; pfam00892 1017264003641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264003642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264003643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1017264003644 dimerization interface [polypeptide binding]; other site 1017264003645 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1017264003646 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1017264003647 Walker A/P-loop; other site 1017264003648 ATP binding site [chemical binding]; other site 1017264003649 Q-loop/lid; other site 1017264003650 ABC transporter signature motif; other site 1017264003651 Walker B; other site 1017264003652 D-loop; other site 1017264003653 H-loop/switch region; other site 1017264003654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264003655 dimer interface [polypeptide binding]; other site 1017264003656 conserved gate region; other site 1017264003657 putative PBP binding loops; other site 1017264003658 ABC-ATPase subunit interface; other site 1017264003659 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1017264003660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1017264003661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264003662 dimer interface [polypeptide binding]; other site 1017264003663 conserved gate region; other site 1017264003664 putative PBP binding loops; other site 1017264003665 ABC-ATPase subunit interface; other site 1017264003666 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264003667 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1017264003668 substrate binding pocket [chemical binding]; other site 1017264003669 membrane-bound complex binding site; other site 1017264003670 hinge residues; other site 1017264003671 aspartate aminotransferase; Provisional; Region: PRK06107 1017264003672 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264003673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264003674 homodimer interface [polypeptide binding]; other site 1017264003675 catalytic residue [active] 1017264003676 hypothetical protein; Validated; Region: PRK06201 1017264003677 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1017264003678 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1017264003679 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 1017264003680 NlpE N-terminal domain; Region: NlpE; pfam04170 1017264003681 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1017264003682 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1017264003683 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1017264003684 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1017264003685 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1017264003686 DNA binding residues [nucleotide binding] 1017264003687 SnoaL-like domain; Region: SnoaL_2; pfam12680 1017264003688 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1017264003689 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1017264003690 dimer interface [polypeptide binding]; other site 1017264003691 ADP-ribose binding site [chemical binding]; other site 1017264003692 active site 1017264003693 nudix motif; other site 1017264003694 metal binding site [ion binding]; metal-binding site 1017264003695 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264003696 catalytic loop [active] 1017264003697 iron binding site [ion binding]; other site 1017264003698 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1017264003699 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1017264003700 ligand binding site [chemical binding]; other site 1017264003701 flexible hinge region; other site 1017264003702 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1017264003703 putative switch regulator; other site 1017264003704 non-specific DNA interactions [nucleotide binding]; other site 1017264003705 DNA binding site [nucleotide binding] 1017264003706 sequence specific DNA binding site [nucleotide binding]; other site 1017264003707 putative cAMP binding site [chemical binding]; other site 1017264003708 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1017264003709 Clp amino terminal domain; Region: Clp_N; pfam02861 1017264003710 Clp amino terminal domain; Region: Clp_N; pfam02861 1017264003711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264003712 Walker A motif; other site 1017264003713 ATP binding site [chemical binding]; other site 1017264003714 Walker B motif; other site 1017264003715 arginine finger; other site 1017264003716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264003717 Walker A motif; other site 1017264003718 ATP binding site [chemical binding]; other site 1017264003719 Walker B motif; other site 1017264003720 arginine finger; other site 1017264003721 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1017264003722 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003723 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003724 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003725 Integrase core domain; Region: rve; pfam00665 1017264003726 Integrase core domain; Region: rve_3; pfam13683 1017264003727 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1017264003728 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1017264003729 hypothetical protein; Provisional; Region: PRK02399 1017264003730 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1017264003731 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 1017264003732 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1017264003733 putative hydrophobic ligand binding site [chemical binding]; other site 1017264003734 protein interface [polypeptide binding]; other site 1017264003735 gate; other site 1017264003736 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264003737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264003738 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1017264003739 putative dimerization interface [polypeptide binding]; other site 1017264003740 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1017264003741 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1017264003742 active site 1017264003743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1017264003744 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264003745 Flavodoxin; Region: Flavodoxin_1; pfam00258 1017264003746 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1017264003747 FAD binding pocket [chemical binding]; other site 1017264003748 FAD binding motif [chemical binding]; other site 1017264003749 catalytic residues [active] 1017264003750 NAD binding pocket [chemical binding]; other site 1017264003751 phosphate binding motif [ion binding]; other site 1017264003752 beta-alpha-beta structure motif; other site 1017264003753 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1017264003754 ApbE family; Region: ApbE; pfam02424 1017264003755 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1017264003756 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 1017264003757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 1017264003758 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1017264003759 nodulation ABC transporter NodI; Provisional; Region: PRK13537 1017264003760 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1017264003761 Walker A/P-loop; other site 1017264003762 ATP binding site [chemical binding]; other site 1017264003763 Q-loop/lid; other site 1017264003764 ABC transporter signature motif; other site 1017264003765 Walker B; other site 1017264003766 D-loop; other site 1017264003767 H-loop/switch region; other site 1017264003768 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1017264003769 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1017264003770 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1017264003771 chromosome condensation membrane protein; Provisional; Region: PRK14196 1017264003772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1017264003773 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1017264003774 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1017264003775 active site lid residues [active] 1017264003776 substrate binding pocket [chemical binding]; other site 1017264003777 catalytic residues [active] 1017264003778 substrate-Mg2+ binding site; other site 1017264003779 aspartate-rich region 1; other site 1017264003780 aspartate-rich region 2; other site 1017264003781 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1017264003782 active site lid residues [active] 1017264003783 substrate binding pocket [chemical binding]; other site 1017264003784 catalytic residues [active] 1017264003785 substrate-Mg2+ binding site; other site 1017264003786 aspartate-rich region 1; other site 1017264003787 aspartate-rich region 2; other site 1017264003788 alanine racemase; Reviewed; Region: alr; PRK00053 1017264003789 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1017264003790 active site 1017264003791 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1017264003792 substrate binding site [chemical binding]; other site 1017264003793 catalytic residues [active] 1017264003794 dimer interface [polypeptide binding]; other site 1017264003795 short chain dehydrogenase; Provisional; Region: PRK07577 1017264003796 classical (c) SDRs; Region: SDR_c; cd05233 1017264003797 NAD(P) binding site [chemical binding]; other site 1017264003798 active site 1017264003799 RNA polymerase sigma factor; Provisional; Region: PRK12513 1017264003800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1017264003801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1017264003802 DNA binding residues [nucleotide binding] 1017264003803 DNA repair protein RadA; Provisional; Region: PRK11823 1017264003804 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1017264003805 Walker A motif/ATP binding site; other site 1017264003806 ATP binding site [chemical binding]; other site 1017264003807 Walker B motif; other site 1017264003808 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1017264003809 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1017264003810 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1017264003811 multidrug efflux protein; Reviewed; Region: PRK01766 1017264003812 cation binding site [ion binding]; other site 1017264003813 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1017264003814 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1017264003815 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1017264003816 arylformamidase; Region: trp_arylform; TIGR03035 1017264003817 hypothetical protein; Reviewed; Region: PRK00024 1017264003818 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1017264003819 MPN+ (JAMM) motif; other site 1017264003820 Zinc-binding site [ion binding]; other site 1017264003821 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1017264003822 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1017264003823 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1017264003824 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1017264003825 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1017264003826 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1017264003827 C-terminal domain interface [polypeptide binding]; other site 1017264003828 GSH binding site (G-site) [chemical binding]; other site 1017264003829 putative dimer interface [polypeptide binding]; other site 1017264003830 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1017264003831 dimer interface [polypeptide binding]; other site 1017264003832 N-terminal domain interface [polypeptide binding]; other site 1017264003833 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1017264003834 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1017264003835 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1017264003836 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1017264003837 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1017264003838 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1017264003839 putative FMN binding site [chemical binding]; other site 1017264003840 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264003841 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264003842 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1017264003843 putative effector binding pocket; other site 1017264003844 dimerization interface [polypeptide binding]; other site 1017264003845 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1017264003846 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1017264003847 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1017264003848 RNA binding surface [nucleotide binding]; other site 1017264003849 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1017264003850 probable active site [active] 1017264003851 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1017264003852 Sm and related proteins; Region: Sm_like; cl00259 1017264003853 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1017264003854 putative oligomer interface [polypeptide binding]; other site 1017264003855 putative RNA binding site [nucleotide binding]; other site 1017264003856 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1017264003857 NusA N-terminal domain; Region: NusA_N; pfam08529 1017264003858 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1017264003859 RNA binding site [nucleotide binding]; other site 1017264003860 homodimer interface [polypeptide binding]; other site 1017264003861 NusA-like KH domain; Region: KH_5; pfam13184 1017264003862 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1017264003863 G-X-X-G motif; other site 1017264003864 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1017264003865 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1017264003866 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1017264003867 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1017264003868 translation initiation factor IF-2; Region: IF-2; TIGR00487 1017264003869 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1017264003870 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1017264003871 G1 box; other site 1017264003872 putative GEF interaction site [polypeptide binding]; other site 1017264003873 GTP/Mg2+ binding site [chemical binding]; other site 1017264003874 Switch I region; other site 1017264003875 G2 box; other site 1017264003876 G3 box; other site 1017264003877 Switch II region; other site 1017264003878 G4 box; other site 1017264003879 G5 box; other site 1017264003880 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1017264003881 Translation-initiation factor 2; Region: IF-2; pfam11987 1017264003882 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1017264003883 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1017264003884 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00020 1017264003885 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1017264003886 RNA binding site [nucleotide binding]; other site 1017264003887 active site 1017264003888 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1017264003889 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1017264003890 G1 box; other site 1017264003891 putative GEF interaction site [polypeptide binding]; other site 1017264003892 GTP/Mg2+ binding site [chemical binding]; other site 1017264003893 Switch I region; other site 1017264003894 G2 box; other site 1017264003895 G3 box; other site 1017264003896 Switch II region; other site 1017264003897 G4 box; other site 1017264003898 G5 box; other site 1017264003899 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1017264003900 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1017264003901 Aerolysin/Pertussis toxin (APT) domain; Region: APT; pfam03440 1017264003902 Pertussis toxin, subunit 2 and 3, C-terminal domain; Region: Pertussis_S2S3; pfam02918 1017264003903 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 1017264003904 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1017264003905 DNA polymerase I; Provisional; Region: PRK05755 1017264003906 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1017264003907 active site 1017264003908 metal binding site 1 [ion binding]; metal-binding site 1017264003909 putative 5' ssDNA interaction site; other site 1017264003910 metal binding site 3; metal-binding site 1017264003911 metal binding site 2 [ion binding]; metal-binding site 1017264003912 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1017264003913 putative DNA binding site [nucleotide binding]; other site 1017264003914 putative metal binding site [ion binding]; other site 1017264003915 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1017264003916 active site 1017264003917 catalytic site [active] 1017264003918 substrate binding site [chemical binding]; other site 1017264003919 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1017264003920 active site 1017264003921 DNA binding site [nucleotide binding] 1017264003922 catalytic site [active] 1017264003923 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1017264003924 Dienelactone hydrolase family; Region: DLH; pfam01738 1017264003925 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1017264003926 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1017264003927 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1017264003928 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1017264003929 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1017264003930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1017264003931 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1017264003932 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1017264003933 metal binding triad; other site 1017264003934 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1017264003935 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1017264003936 metal binding triad; other site 1017264003937 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1017264003938 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1017264003939 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1017264003940 RNA binding site [nucleotide binding]; other site 1017264003941 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1017264003942 multimer interface [polypeptide binding]; other site 1017264003943 Walker A motif; other site 1017264003944 ATP binding site [chemical binding]; other site 1017264003945 Walker B motif; other site 1017264003946 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1017264003947 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1017264003948 catalytic residues [active] 1017264003949 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1017264003950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264003951 ATP binding site [chemical binding]; other site 1017264003952 Mg2+ binding site [ion binding]; other site 1017264003953 G-X-G motif; other site 1017264003954 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1017264003955 anchoring element; other site 1017264003956 dimer interface [polypeptide binding]; other site 1017264003957 ATP binding site [chemical binding]; other site 1017264003958 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1017264003959 active site 1017264003960 metal binding site [ion binding]; metal-binding site 1017264003961 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1017264003962 YcxB-like protein; Region: YcxB; pfam14317 1017264003963 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1017264003964 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1017264003965 CAP-like domain; other site 1017264003966 active site 1017264003967 primary dimer interface [polypeptide binding]; other site 1017264003968 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1017264003969 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264003970 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264003971 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264003972 Integrase core domain; Region: rve; pfam00665 1017264003973 Integrase core domain; Region: rve_3; pfam13683 1017264003974 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1017264003975 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1017264003976 C-terminal domain interface [polypeptide binding]; other site 1017264003977 GSH binding site (G-site) [chemical binding]; other site 1017264003978 dimer interface [polypeptide binding]; other site 1017264003979 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1017264003980 dimer interface [polypeptide binding]; other site 1017264003981 N-terminal domain interface [polypeptide binding]; other site 1017264003982 substrate binding pocket (H-site) [chemical binding]; other site 1017264003983 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1017264003984 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1017264003985 Walker A/P-loop; other site 1017264003986 ATP binding site [chemical binding]; other site 1017264003987 Q-loop/lid; other site 1017264003988 ABC transporter signature motif; other site 1017264003989 Walker B; other site 1017264003990 D-loop; other site 1017264003991 H-loop/switch region; other site 1017264003992 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1017264003993 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264003994 Walker A/P-loop; other site 1017264003995 ATP binding site [chemical binding]; other site 1017264003996 Q-loop/lid; other site 1017264003997 ABC transporter signature motif; other site 1017264003998 Walker B; other site 1017264003999 D-loop; other site 1017264004000 H-loop/switch region; other site 1017264004001 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1017264004002 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1017264004003 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1017264004004 TM-ABC transporter signature motif; other site 1017264004005 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1017264004006 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264004007 TM-ABC transporter signature motif; other site 1017264004008 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1017264004009 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1017264004010 dimerization interface [polypeptide binding]; other site 1017264004011 ligand binding site [chemical binding]; other site 1017264004012 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004013 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004014 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004015 Integrase core domain; Region: rve; pfam00665 1017264004016 Integrase core domain; Region: rve_3; pfam13683 1017264004017 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1017264004018 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1017264004019 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1017264004020 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1017264004021 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1017264004022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264004023 dimer interface [polypeptide binding]; other site 1017264004024 conserved gate region; other site 1017264004025 putative PBP binding loops; other site 1017264004026 ABC-ATPase subunit interface; other site 1017264004027 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1017264004028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264004029 dimer interface [polypeptide binding]; other site 1017264004030 conserved gate region; other site 1017264004031 putative PBP binding loops; other site 1017264004032 ABC-ATPase subunit interface; other site 1017264004033 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1017264004034 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1017264004035 Walker A/P-loop; other site 1017264004036 ATP binding site [chemical binding]; other site 1017264004037 Q-loop/lid; other site 1017264004038 ABC transporter signature motif; other site 1017264004039 Walker B; other site 1017264004040 D-loop; other site 1017264004041 H-loop/switch region; other site 1017264004042 TOBE domain; Region: TOBE_2; pfam08402 1017264004043 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1017264004044 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1017264004045 dimerization interface [polypeptide binding]; other site 1017264004046 ligand binding site [chemical binding]; other site 1017264004047 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1017264004048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1017264004049 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004050 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004051 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004052 Integrase core domain; Region: rve; pfam00665 1017264004053 Integrase core domain; Region: rve_3; pfam13683 1017264004054 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1017264004055 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1017264004056 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1017264004057 RES domain; Region: RES; pfam08808 1017264004058 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1017264004059 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1017264004060 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1017264004061 phosphate binding site [ion binding]; other site 1017264004062 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1017264004063 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1017264004064 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1017264004065 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1017264004066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1017264004067 Coenzyme A binding pocket [chemical binding]; other site 1017264004068 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1017264004069 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1017264004070 C-terminal domain interface [polypeptide binding]; other site 1017264004071 GSH binding site (G-site) [chemical binding]; other site 1017264004072 dimer interface [polypeptide binding]; other site 1017264004073 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1017264004074 N-terminal domain interface [polypeptide binding]; other site 1017264004075 putative dimer interface [polypeptide binding]; other site 1017264004076 active site 1017264004077 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1017264004078 catalytic residues [active] 1017264004079 dimer interface [polypeptide binding]; other site 1017264004080 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1017264004081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1017264004082 TPR repeat; Region: TPR_11; pfam13414 1017264004083 binding surface 1017264004084 TPR motif; other site 1017264004085 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264004086 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264004087 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1017264004088 ArsC family; Region: ArsC; pfam03960 1017264004089 catalytic residues [active] 1017264004090 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1017264004091 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1017264004092 catalytic triad [active] 1017264004093 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004094 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004095 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004096 Integrase core domain; Region: rve; pfam00665 1017264004097 Integrase core domain; Region: rve_3; pfam13683 1017264004098 DoxX; Region: DoxX; pfam07681 1017264004099 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1017264004100 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1017264004101 active site 1017264004102 catalytic tetrad [active] 1017264004103 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1017264004104 Ligand Binding Site [chemical binding]; other site 1017264004105 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1017264004106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264004107 DNA-binding site [nucleotide binding]; DNA binding site 1017264004108 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264004109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264004110 homodimer interface [polypeptide binding]; other site 1017264004111 catalytic residue [active] 1017264004112 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1017264004113 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1017264004114 catalytic residue [active] 1017264004115 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1017264004116 dimer interface [polypeptide binding]; other site 1017264004117 pyridoxamine kinase; Validated; Region: PRK05756 1017264004118 pyridoxal binding site [chemical binding]; other site 1017264004119 ATP binding site [chemical binding]; other site 1017264004120 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1017264004121 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1017264004122 active site 1017264004123 catalytic site [active] 1017264004124 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1017264004125 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1017264004126 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1017264004127 catalytic site [active] 1017264004128 active site 1017264004129 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1017264004130 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1017264004131 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1017264004132 active site 1017264004133 catalytic site [active] 1017264004134 glycogen branching enzyme; Provisional; Region: PRK05402 1017264004135 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1017264004136 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1017264004137 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1017264004138 active site 1017264004139 catalytic site [active] 1017264004140 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1017264004141 trehalose synthase; Region: treS_nterm; TIGR02456 1017264004142 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1017264004143 active site 1017264004144 catalytic site [active] 1017264004145 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1017264004146 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1017264004147 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004148 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004149 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004150 Integrase core domain; Region: rve; pfam00665 1017264004151 Integrase core domain; Region: rve_3; pfam13683 1017264004152 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1017264004153 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1017264004154 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 1017264004155 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004156 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004157 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004158 Integrase core domain; Region: rve; pfam00665 1017264004159 Integrase core domain; Region: rve_3; pfam13683 1017264004160 cardiolipin synthase 2; Provisional; Region: PRK11263 1017264004161 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1017264004162 putative active site [active] 1017264004163 catalytic site [active] 1017264004164 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1017264004165 putative active site [active] 1017264004166 catalytic site [active] 1017264004167 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1017264004168 putative catalytic site [active] 1017264004169 putative metal binding site [ion binding]; other site 1017264004170 putative phosphate binding site [ion binding]; other site 1017264004171 Predicted transcriptional regulators [Transcription]; Region: COG1695 1017264004172 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1017264004173 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1017264004174 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1017264004175 Autotransporter beta-domain; Region: Autotransporter; smart00869 1017264004176 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1017264004177 RNase_H superfamily; Region: RNase_H_2; pfam13482 1017264004178 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1017264004179 AAA domain; Region: AAA_12; pfam13087 1017264004180 LysR family transcriptional regulator; Provisional; Region: PRK14997 1017264004181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264004182 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1017264004183 putative effector binding pocket; other site 1017264004184 putative dimerization interface [polypeptide binding]; other site 1017264004185 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1017264004186 Predicted flavoprotein [General function prediction only]; Region: COG0431 1017264004187 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1017264004188 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1017264004189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264004190 DNA-binding site [nucleotide binding]; DNA binding site 1017264004191 FCD domain; Region: FCD; pfam07729 1017264004192 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1017264004193 CoA binding domain; Region: CoA_binding_2; pfam13380 1017264004194 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1017264004195 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1017264004196 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264004197 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1017264004198 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1017264004199 active site 1017264004200 citrylCoA binding site [chemical binding]; other site 1017264004201 oxalacetate binding site [chemical binding]; other site 1017264004202 coenzyme A binding site [chemical binding]; other site 1017264004203 catalytic triad [active] 1017264004204 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264004205 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264004206 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264004207 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1017264004208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1017264004209 DNA binding site [nucleotide binding] 1017264004210 domain linker motif; other site 1017264004211 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1017264004212 dimerization interface [polypeptide binding]; other site 1017264004213 ligand binding site [chemical binding]; other site 1017264004214 3-isopropylmalate dehydratase, small subunit; Region: leuD; TIGR00171 1017264004215 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1017264004216 substrate binding site [chemical binding]; other site 1017264004217 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264004218 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1017264004219 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 1017264004220 putative active site pocket [active] 1017264004221 metal binding site [ion binding]; metal-binding site 1017264004222 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1017264004223 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1017264004224 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1017264004225 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004226 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004227 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004228 Integrase core domain; Region: rve; pfam00665 1017264004229 Integrase core domain; Region: rve_3; pfam13683 1017264004230 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1017264004231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264004232 Walker A/P-loop; other site 1017264004233 ATP binding site [chemical binding]; other site 1017264004234 Q-loop/lid; other site 1017264004235 ABC transporter signature motif; other site 1017264004236 Walker B; other site 1017264004237 D-loop; other site 1017264004238 H-loop/switch region; other site 1017264004239 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1017264004240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264004241 dimer interface [polypeptide binding]; other site 1017264004242 conserved gate region; other site 1017264004243 putative PBP binding loops; other site 1017264004244 ABC-ATPase subunit interface; other site 1017264004245 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1017264004246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264004247 substrate binding pocket [chemical binding]; other site 1017264004248 membrane-bound complex binding site; other site 1017264004249 hinge residues; other site 1017264004250 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264004251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264004252 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264004253 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1017264004254 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1017264004255 FlgN protein; Region: FlgN; pfam05130 1017264004256 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1017264004257 SAF-like; Region: SAF_2; pfam13144 1017264004258 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1017264004259 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1017264004260 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1017264004261 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1017264004262 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1017264004263 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1017264004264 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK12633 1017264004265 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1017264004266 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1017264004267 flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637 1017264004268 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1017264004269 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1017264004270 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1017264004271 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1017264004272 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1017264004273 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1017264004274 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 1017264004275 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1017264004276 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1017264004277 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12700 1017264004278 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1017264004279 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1017264004280 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1017264004281 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12713 1017264004282 Rod binding protein; Region: Rod-binding; cl01626 1017264004283 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1017264004284 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1017264004285 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1017264004286 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12718 1017264004287 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1017264004288 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1017264004289 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1017264004290 dimer interface [polypeptide binding]; other site 1017264004291 ligand binding site [chemical binding]; other site 1017264004292 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1017264004293 dimerization interface [polypeptide binding]; other site 1017264004294 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1017264004295 dimer interface [polypeptide binding]; other site 1017264004296 putative CheW interface [polypeptide binding]; other site 1017264004297 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1017264004298 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1017264004299 dimer interface [polypeptide binding]; other site 1017264004300 ligand binding site [chemical binding]; other site 1017264004301 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1017264004302 dimerization interface [polypeptide binding]; other site 1017264004303 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1017264004304 dimer interface [polypeptide binding]; other site 1017264004305 putative CheW interface [polypeptide binding]; other site 1017264004306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1017264004307 PAS fold; Region: PAS_3; pfam08447 1017264004308 putative active site [active] 1017264004309 heme pocket [chemical binding]; other site 1017264004310 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1017264004311 dimerization interface [polypeptide binding]; other site 1017264004312 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1017264004313 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1017264004314 dimer interface [polypeptide binding]; other site 1017264004315 putative CheW interface [polypeptide binding]; other site 1017264004316 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264004317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264004318 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264004319 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1017264004320 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1017264004321 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1017264004322 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1017264004323 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1017264004324 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1017264004325 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1017264004326 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1017264004327 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004328 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004329 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004330 Integrase core domain; Region: rve; pfam00665 1017264004331 Integrase core domain; Region: rve_3; pfam13683 1017264004332 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1017264004333 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1017264004334 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1017264004335 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1017264004336 Walker A motif/ATP binding site; other site 1017264004337 Walker B motif; other site 1017264004338 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1017264004339 Flagellar assembly protein FliH; Region: FliH; pfam02108 1017264004340 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1017264004341 FliG C-terminal domain; Region: FliG_C; pfam01706 1017264004342 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1017264004343 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1017264004344 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1017264004345 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1017264004346 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1017264004347 Flagellar protein FliT; Region: FliT; pfam05400 1017264004348 Flagellar protein FliS; Region: FliS; cl00654 1017264004349 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1017264004350 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1017264004351 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1017264004352 FlaG protein; Region: FlaG; pfam03646 1017264004353 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1017264004354 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1017264004355 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1017264004356 Sporulation related domain; Region: SPOR; pfam05036 1017264004357 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1017264004358 Colicin V production protein; Region: Colicin_V; pfam02674 1017264004359 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1017264004360 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1017264004361 active site 1017264004362 tetramer interface [polypeptide binding]; other site 1017264004363 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1017264004364 active site 1017264004365 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1017264004366 PII uridylyl-transferase; Provisional; Region: PRK03059 1017264004367 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1017264004368 metal binding triad; other site 1017264004369 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1017264004370 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1017264004371 Zn2+ binding site [ion binding]; other site 1017264004372 Mg2+ binding site [ion binding]; other site 1017264004373 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1017264004374 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1017264004375 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1017264004376 active site 1017264004377 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1017264004378 rRNA interaction site [nucleotide binding]; other site 1017264004379 S8 interaction site; other site 1017264004380 putative laminin-1 binding site; other site 1017264004381 elongation factor Ts; Provisional; Region: tsf; PRK09377 1017264004382 UBA/TS-N domain; Region: UBA; pfam00627 1017264004383 Elongation factor TS; Region: EF_TS; pfam00889 1017264004384 Elongation factor TS; Region: EF_TS; pfam00889 1017264004385 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1017264004386 putative nucleotide binding site [chemical binding]; other site 1017264004387 uridine monophosphate binding site [chemical binding]; other site 1017264004388 homohexameric interface [polypeptide binding]; other site 1017264004389 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1017264004390 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1017264004391 hinge region; other site 1017264004392 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 1017264004393 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1017264004394 catalytic residue [active] 1017264004395 putative FPP diphosphate binding site; other site 1017264004396 putative FPP binding hydrophobic cleft; other site 1017264004397 dimer interface [polypeptide binding]; other site 1017264004398 putative IPP diphosphate binding site; other site 1017264004399 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1017264004400 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1017264004401 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1017264004402 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1017264004403 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1017264004404 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1017264004405 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1017264004406 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1017264004407 active site 1017264004408 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1017264004409 putative substrate binding region [chemical binding]; other site 1017264004410 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1017264004411 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1017264004412 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1017264004413 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1017264004414 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1017264004415 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1017264004416 Surface antigen; Region: Bac_surface_Ag; pfam01103 1017264004417 periplasmic chaperone; Provisional; Region: PRK10780 1017264004418 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1017264004419 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1017264004420 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 1017264004421 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1017264004422 trimer interface [polypeptide binding]; other site 1017264004423 active site 1017264004424 UDP-GlcNAc binding site [chemical binding]; other site 1017264004425 lipid binding site [chemical binding]; lipid-binding site 1017264004426 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1017264004427 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1017264004428 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1017264004429 active site 1017264004430 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1017264004431 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1017264004432 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1017264004433 RNA/DNA hybrid binding site [nucleotide binding]; other site 1017264004434 active site 1017264004435 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1017264004436 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1017264004437 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1017264004438 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1017264004439 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1017264004440 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1017264004441 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1017264004442 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1017264004443 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1017264004444 catalytic triad [active] 1017264004445 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004446 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004447 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004448 Integrase core domain; Region: rve; pfam00665 1017264004449 Integrase core domain; Region: rve_3; pfam13683 1017264004450 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1017264004451 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1017264004452 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1017264004453 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1017264004454 metal binding site [ion binding]; metal-binding site 1017264004455 active site 1017264004456 I-site; other site 1017264004457 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1017264004458 SmpB-tmRNA interface; other site 1017264004459 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1017264004460 putative coenzyme Q binding site [chemical binding]; other site 1017264004461 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 1017264004462 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1017264004463 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1017264004464 active site 1017264004465 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1017264004466 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264004467 substrate binding site [chemical binding]; other site 1017264004468 oxyanion hole (OAH) forming residues; other site 1017264004469 trimer interface [polypeptide binding]; other site 1017264004470 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1017264004471 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1017264004472 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1017264004473 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1017264004474 CoenzymeA binding site [chemical binding]; other site 1017264004475 subunit interaction site [polypeptide binding]; other site 1017264004476 PHB binding site; other site 1017264004477 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1017264004478 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004479 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004480 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004481 Integrase core domain; Region: rve; pfam00665 1017264004482 Integrase core domain; Region: rve_3; pfam13683 1017264004483 transaldolase-like protein; Provisional; Region: PTZ00411 1017264004484 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1017264004485 active site 1017264004486 dimer interface [polypeptide binding]; other site 1017264004487 catalytic residue [active] 1017264004488 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1017264004489 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1017264004490 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1017264004491 catalytic site [active] 1017264004492 subunit interface [polypeptide binding]; other site 1017264004493 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1017264004494 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1017264004495 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1017264004496 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1017264004497 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1017264004498 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1017264004499 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1017264004500 IMP binding site; other site 1017264004501 dimer interface [polypeptide binding]; other site 1017264004502 interdomain contacts; other site 1017264004503 partial ornithine binding site; other site 1017264004504 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1017264004505 catalytic core [active] 1017264004506 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264004507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264004508 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1017264004509 dimerization interface [polypeptide binding]; other site 1017264004510 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1017264004511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264004512 Walker A/P-loop; other site 1017264004513 ATP binding site [chemical binding]; other site 1017264004514 Q-loop/lid; other site 1017264004515 ABC transporter signature motif; other site 1017264004516 Walker B; other site 1017264004517 D-loop; other site 1017264004518 H-loop/switch region; other site 1017264004519 TOBE domain; Region: TOBE_2; pfam08402 1017264004520 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1017264004521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264004522 dimer interface [polypeptide binding]; other site 1017264004523 conserved gate region; other site 1017264004524 putative PBP binding loops; other site 1017264004525 ABC-ATPase subunit interface; other site 1017264004526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264004527 dimer interface [polypeptide binding]; other site 1017264004528 conserved gate region; other site 1017264004529 putative PBP binding loops; other site 1017264004530 ABC-ATPase subunit interface; other site 1017264004531 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004532 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004533 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004534 Integrase core domain; Region: rve; pfam00665 1017264004535 Integrase core domain; Region: rve_3; pfam13683 1017264004536 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1017264004537 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1017264004538 Tetramer interface [polypeptide binding]; other site 1017264004539 active site 1017264004540 FMN-binding site [chemical binding]; other site 1017264004541 Peptidase family M48; Region: Peptidase_M48; pfam01435 1017264004542 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1017264004543 Walker A motif; other site 1017264004544 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1017264004545 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1017264004546 dimer interface [polypeptide binding]; other site 1017264004547 putative functional site; other site 1017264004548 putative MPT binding site; other site 1017264004549 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1017264004550 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1017264004551 GTP binding site; other site 1017264004552 Domain of unknown function DUF59; Region: DUF59; pfam01883 1017264004553 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1017264004554 Walker A motif; other site 1017264004555 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 1017264004556 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 1017264004557 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1017264004558 4Fe-4S binding domain; Region: Fer4; pfam00037 1017264004559 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1017264004560 4Fe-4S binding domain; Region: Fer4; pfam00037 1017264004561 4Fe-4S binding domain; Region: Fer4; pfam00037 1017264004562 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1017264004563 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 1017264004564 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1017264004565 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1017264004566 [4Fe-4S] binding site [ion binding]; other site 1017264004567 molybdopterin cofactor binding site; other site 1017264004568 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1017264004569 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1017264004570 molybdopterin cofactor binding site; other site 1017264004571 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1017264004572 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1017264004573 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1017264004574 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1017264004575 PBP superfamily domain; Region: PBP_like; pfam12727 1017264004576 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1017264004577 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1017264004578 Walker A/P-loop; other site 1017264004579 ATP binding site [chemical binding]; other site 1017264004580 Q-loop/lid; other site 1017264004581 ABC transporter signature motif; other site 1017264004582 Walker B; other site 1017264004583 D-loop; other site 1017264004584 H-loop/switch region; other site 1017264004585 PBP superfamily domain; Region: PBP_like_2; pfam12849 1017264004586 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1017264004587 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1017264004588 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1017264004589 substrate binding site [chemical binding]; other site 1017264004590 ligand binding site [chemical binding]; other site 1017264004591 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1017264004592 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1017264004593 substrate binding site [chemical binding]; other site 1017264004594 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1017264004595 tartrate dehydrogenase; Region: TTC; TIGR02089 1017264004596 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1017264004597 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1017264004598 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1017264004599 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1017264004600 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1017264004601 dimerization interface 3.5A [polypeptide binding]; other site 1017264004602 active site 1017264004603 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1017264004604 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1017264004605 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 1017264004606 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1017264004607 DctM-like transporters; Region: DctM; pfam06808 1017264004608 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1017264004609 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1017264004610 active site 1017264004611 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1017264004612 GAF domain; Region: GAF; pfam01590 1017264004613 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1017264004614 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1017264004615 metal binding site [ion binding]; metal-binding site 1017264004616 active site 1017264004617 I-site; other site 1017264004618 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004619 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004620 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004621 Integrase core domain; Region: rve; pfam00665 1017264004622 Integrase core domain; Region: rve_3; pfam13683 1017264004623 Response regulator receiver domain; Region: Response_reg; pfam00072 1017264004624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264004625 active site 1017264004626 phosphorylation site [posttranslational modification] 1017264004627 intermolecular recognition site; other site 1017264004628 dimerization interface [polypeptide binding]; other site 1017264004629 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1017264004630 DNA binding residues [nucleotide binding] 1017264004631 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1017264004632 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1017264004633 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1017264004634 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1017264004635 active site 1017264004636 dimer interface [polypeptide binding]; other site 1017264004637 motif 1; other site 1017264004638 motif 2; other site 1017264004639 motif 3; other site 1017264004640 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1017264004641 anticodon binding site; other site 1017264004642 translation initiation factor IF-3; Region: infC; TIGR00168 1017264004643 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1017264004644 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1017264004645 glutathione synthetase; Provisional; Region: PRK05246 1017264004646 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1017264004647 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1017264004648 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1017264004649 active pocket/dimerization site; other site 1017264004650 active site 1017264004651 phosphorylation site [posttranslational modification] 1017264004652 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1017264004653 dimerization domain swap beta strand [polypeptide binding]; other site 1017264004654 regulatory protein interface [polypeptide binding]; other site 1017264004655 active site 1017264004656 regulatory phosphorylation site [posttranslational modification]; other site 1017264004657 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1017264004658 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1017264004659 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1017264004660 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1017264004661 ornithine cyclodeaminase; Validated; Region: PRK06141 1017264004662 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1017264004663 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1017264004664 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1017264004665 putative ligand binding site [chemical binding]; other site 1017264004666 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 1017264004667 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264004668 substrate binding pocket [chemical binding]; other site 1017264004669 membrane-bound complex binding site; other site 1017264004670 hinge residues; other site 1017264004671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264004672 dimer interface [polypeptide binding]; other site 1017264004673 conserved gate region; other site 1017264004674 putative PBP binding loops; other site 1017264004675 ABC-ATPase subunit interface; other site 1017264004676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264004677 dimer interface [polypeptide binding]; other site 1017264004678 conserved gate region; other site 1017264004679 putative PBP binding loops; other site 1017264004680 ABC-ATPase subunit interface; other site 1017264004681 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1017264004682 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1017264004683 Walker A/P-loop; other site 1017264004684 ATP binding site [chemical binding]; other site 1017264004685 Q-loop/lid; other site 1017264004686 ABC transporter signature motif; other site 1017264004687 Walker B; other site 1017264004688 D-loop; other site 1017264004689 H-loop/switch region; other site 1017264004690 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004691 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004692 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004693 Integrase core domain; Region: rve; pfam00665 1017264004694 Integrase core domain; Region: rve_3; pfam13683 1017264004695 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1017264004696 formate dehydrogenase; Provisional; Region: PRK07574 1017264004697 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1017264004698 dimerization interface [polypeptide binding]; other site 1017264004699 ligand binding site [chemical binding]; other site 1017264004700 NAD binding site [chemical binding]; other site 1017264004701 catalytic site [active] 1017264004702 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 1017264004703 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 1017264004704 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1017264004705 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1017264004706 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1017264004707 DNA binding residues [nucleotide binding] 1017264004708 dimerization interface [polypeptide binding]; other site 1017264004709 MOSC domain; Region: MOSC; pfam03473 1017264004710 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1017264004711 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1017264004712 intersubunit interface [polypeptide binding]; other site 1017264004713 active site 1017264004714 zinc binding site [ion binding]; other site 1017264004715 Na+ binding site [ion binding]; other site 1017264004716 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1017264004717 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1017264004718 ATP binding site [chemical binding]; other site 1017264004719 active site 1017264004720 substrate binding site [chemical binding]; other site 1017264004721 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 1017264004722 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1017264004723 toxin interface [polypeptide binding]; other site 1017264004724 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1017264004725 Zn binding site [ion binding]; other site 1017264004726 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 1017264004727 non-specific DNA binding site [nucleotide binding]; other site 1017264004728 salt bridge; other site 1017264004729 sequence-specific DNA binding site [nucleotide binding]; other site 1017264004730 AIR carboxylase; Region: AIRC; pfam00731 1017264004731 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1017264004732 ATP-grasp domain; Region: ATP-grasp; pfam02222 1017264004733 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1017264004734 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1017264004735 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1017264004736 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264004737 substrate binding pocket [chemical binding]; other site 1017264004738 membrane-bound complex binding site; other site 1017264004739 hinge residues; other site 1017264004740 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264004741 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1017264004742 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264004743 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1017264004744 agmatinase; Region: agmatinase; TIGR01230 1017264004745 oligomer interface [polypeptide binding]; other site 1017264004746 putative active site [active] 1017264004747 Mn binding site [ion binding]; other site 1017264004748 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264004749 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1017264004750 substrate binding pocket [chemical binding]; other site 1017264004751 membrane-bound complex binding site; other site 1017264004752 hinge residues; other site 1017264004753 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1017264004754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264004755 dimer interface [polypeptide binding]; other site 1017264004756 conserved gate region; other site 1017264004757 putative PBP binding loops; other site 1017264004758 ABC-ATPase subunit interface; other site 1017264004759 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1017264004760 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1017264004761 Walker A/P-loop; other site 1017264004762 ATP binding site [chemical binding]; other site 1017264004763 Q-loop/lid; other site 1017264004764 ABC transporter signature motif; other site 1017264004765 Walker B; other site 1017264004766 D-loop; other site 1017264004767 H-loop/switch region; other site 1017264004768 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1017264004769 PYR/PP interface [polypeptide binding]; other site 1017264004770 dimer interface [polypeptide binding]; other site 1017264004771 TPP binding site [chemical binding]; other site 1017264004772 hypothetical protein; Validated; Region: PRK07586 1017264004773 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1017264004774 TPP-binding site [chemical binding]; other site 1017264004775 dimer interface [polypeptide binding]; other site 1017264004776 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1017264004777 putative active site [active] 1017264004778 putative catalytic site [active] 1017264004779 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1017264004780 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1017264004781 FAD binding site [chemical binding]; other site 1017264004782 substrate binding pocket [chemical binding]; other site 1017264004783 catalytic base [active] 1017264004784 thiamine pyrophosphate protein; Validated; Region: PRK08199 1017264004785 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1017264004786 PYR/PP interface [polypeptide binding]; other site 1017264004787 dimer interface [polypeptide binding]; other site 1017264004788 TPP binding site [chemical binding]; other site 1017264004789 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1017264004790 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1017264004791 TPP-binding site [chemical binding]; other site 1017264004792 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1017264004793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264004794 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264004795 dimerization interface [polypeptide binding]; other site 1017264004796 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1017264004797 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1017264004798 active site 1017264004799 DNA binding site [nucleotide binding] 1017264004800 Int/Topo IB signature motif; other site 1017264004801 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1017264004802 putative deacylase active site [active] 1017264004803 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1017264004804 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1017264004805 conserved cys residue [active] 1017264004806 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 1017264004807 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004808 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004809 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004810 Integrase core domain; Region: rve; pfam00665 1017264004811 Integrase core domain; Region: rve_3; pfam13683 1017264004812 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1017264004813 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1017264004814 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1017264004815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264004816 putative substrate translocation pore; other site 1017264004817 probable DNA repair protein; Region: TIGR03623 1017264004818 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1017264004819 Part of AAA domain; Region: AAA_19; pfam13245 1017264004820 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1017264004821 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1017264004822 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1017264004823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264004824 Walker A motif; other site 1017264004825 ATP binding site [chemical binding]; other site 1017264004826 Walker B motif; other site 1017264004827 arginine finger; other site 1017264004828 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1017264004829 hypothetical protein; Validated; Region: PRK00153 1017264004830 recombination protein RecR; Reviewed; Region: recR; PRK00076 1017264004831 RecR protein; Region: RecR; pfam02132 1017264004832 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1017264004833 putative active site [active] 1017264004834 putative metal-binding site [ion binding]; other site 1017264004835 tetramer interface [polypeptide binding]; other site 1017264004836 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004837 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004838 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004839 Integrase core domain; Region: rve; pfam00665 1017264004840 Integrase core domain; Region: rve_3; pfam13683 1017264004841 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 1017264004842 Predicted metalloprotease [General function prediction only]; Region: COG2321 1017264004843 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1017264004844 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1017264004845 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004846 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004847 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004848 Integrase core domain; Region: rve; pfam00665 1017264004849 Integrase core domain; Region: rve_3; pfam13683 1017264004850 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 1017264004851 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1017264004852 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1017264004853 Imelysin; Region: Peptidase_M75; cl09159 1017264004854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1017264004855 Predicted flavoprotein [General function prediction only]; Region: COG0431 1017264004856 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1017264004857 Dodecin; Region: Dodecin; pfam07311 1017264004858 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1017264004859 MutS domain I; Region: MutS_I; pfam01624 1017264004860 MutS domain II; Region: MutS_II; pfam05188 1017264004861 MutS domain III; Region: MutS_III; pfam05192 1017264004862 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1017264004863 Walker A/P-loop; other site 1017264004864 ATP binding site [chemical binding]; other site 1017264004865 Q-loop/lid; other site 1017264004866 ABC transporter signature motif; other site 1017264004867 Walker B; other site 1017264004868 D-loop; other site 1017264004869 H-loop/switch region; other site 1017264004870 Cupin superfamily protein; Region: Cupin_4; pfam08007 1017264004871 Cupin-like domain; Region: Cupin_8; pfam13621 1017264004872 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1017264004873 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1017264004874 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1017264004875 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1017264004876 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1017264004877 dimer interface [polypeptide binding]; other site 1017264004878 active site 1017264004879 catalytic residue [active] 1017264004880 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004881 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004882 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004883 Integrase core domain; Region: rve; pfam00665 1017264004884 Integrase core domain; Region: rve_3; pfam13683 1017264004885 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1017264004886 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264004887 substrate binding pocket [chemical binding]; other site 1017264004888 membrane-bound complex binding site; other site 1017264004889 hinge residues; other site 1017264004890 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1017264004891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264004892 dimer interface [polypeptide binding]; other site 1017264004893 conserved gate region; other site 1017264004894 putative PBP binding loops; other site 1017264004895 ABC-ATPase subunit interface; other site 1017264004896 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1017264004897 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1017264004898 Walker A/P-loop; other site 1017264004899 ATP binding site [chemical binding]; other site 1017264004900 Q-loop/lid; other site 1017264004901 ABC transporter signature motif; other site 1017264004902 Walker B; other site 1017264004903 D-loop; other site 1017264004904 H-loop/switch region; other site 1017264004905 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1017264004906 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1017264004907 Zn2+ binding site [ion binding]; other site 1017264004908 Mg2+ binding site [ion binding]; other site 1017264004909 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1017264004910 synthetase active site [active] 1017264004911 NTP binding site [chemical binding]; other site 1017264004912 metal binding site [ion binding]; metal-binding site 1017264004913 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1017264004914 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1017264004915 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1017264004916 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1017264004917 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1017264004918 catalytic site [active] 1017264004919 G-X2-G-X-G-K; other site 1017264004920 Cytochrome c [Energy production and conversion]; Region: COG3258 1017264004921 Cytochrome c; Region: Cytochrom_C; pfam00034 1017264004922 Cytochrome c; Region: Cytochrom_C; cl11414 1017264004923 Cytochrome c; Region: Cytochrom_C; cl11414 1017264004924 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1017264004925 classical (c) SDRs; Region: SDR_c; cd05233 1017264004926 NAD(P) binding site [chemical binding]; other site 1017264004927 active site 1017264004928 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1017264004929 NlpC/P60 family; Region: NLPC_P60; pfam00877 1017264004930 AMP nucleosidase; Provisional; Region: PRK08292 1017264004931 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1017264004932 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1017264004933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1017264004934 non-specific DNA binding site [nucleotide binding]; other site 1017264004935 salt bridge; other site 1017264004936 sequence-specific DNA binding site [nucleotide binding]; other site 1017264004937 hypothetical protein; Provisional; Region: PRK11820 1017264004938 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1017264004939 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1017264004940 ribonuclease PH; Reviewed; Region: rph; PRK00173 1017264004941 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1017264004942 hexamer interface [polypeptide binding]; other site 1017264004943 active site 1017264004944 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1017264004945 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264004946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264004947 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1017264004948 putative dimerization interface [polypeptide binding]; other site 1017264004949 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1017264004950 dimerization interface [polypeptide binding]; other site 1017264004951 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1017264004952 dimer interface [polypeptide binding]; other site 1017264004953 putative CheW interface [polypeptide binding]; other site 1017264004954 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1017264004955 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1017264004956 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1017264004957 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1017264004958 metal binding site [ion binding]; metal-binding site 1017264004959 active site 1017264004960 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1017264004961 active site 1017264004962 dimerization interface [polypeptide binding]; other site 1017264004963 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264004964 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264004965 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264004966 Integrase core domain; Region: rve; pfam00665 1017264004967 Integrase core domain; Region: rve_3; pfam13683 1017264004968 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 1017264004969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1017264004970 FeS/SAM binding site; other site 1017264004971 HemN C-terminal domain; Region: HemN_C; pfam06969 1017264004972 glutamine synthetase; Provisional; Region: glnA; PRK09469 1017264004973 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1017264004974 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1017264004975 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1017264004976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1017264004977 putative active site [active] 1017264004978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264004979 dimer interface [polypeptide binding]; other site 1017264004980 phosphorylation site [posttranslational modification] 1017264004981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264004982 ATP binding site [chemical binding]; other site 1017264004983 Mg2+ binding site [ion binding]; other site 1017264004984 G-X-G motif; other site 1017264004985 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1017264004986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264004987 active site 1017264004988 phosphorylation site [posttranslational modification] 1017264004989 intermolecular recognition site; other site 1017264004990 dimerization interface [polypeptide binding]; other site 1017264004991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264004992 Walker A motif; other site 1017264004993 ATP binding site [chemical binding]; other site 1017264004994 Walker B motif; other site 1017264004995 arginine finger; other site 1017264004996 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1017264004997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264004998 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1017264004999 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264005000 dimerization interface [polypeptide binding]; other site 1017264005001 Pirin-related protein [General function prediction only]; Region: COG1741 1017264005002 Pirin; Region: Pirin; pfam02678 1017264005003 Pirin-related protein [General function prediction only]; Region: COG1741 1017264005004 Pirin; Region: Pirin; pfam02678 1017264005005 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1017264005006 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005007 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005008 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005009 Integrase core domain; Region: rve; pfam00665 1017264005010 Integrase core domain; Region: rve_3; pfam13683 1017264005011 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1017264005012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264005013 dimer interface [polypeptide binding]; other site 1017264005014 conserved gate region; other site 1017264005015 putative PBP binding loops; other site 1017264005016 ABC-ATPase subunit interface; other site 1017264005017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264005018 dimer interface [polypeptide binding]; other site 1017264005019 conserved gate region; other site 1017264005020 ABC-ATPase subunit interface; other site 1017264005021 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1017264005022 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1017264005023 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1017264005024 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1017264005025 FAD binding pocket [chemical binding]; other site 1017264005026 FAD binding motif [chemical binding]; other site 1017264005027 phosphate binding motif [ion binding]; other site 1017264005028 beta-alpha-beta structure motif; other site 1017264005029 NAD binding pocket [chemical binding]; other site 1017264005030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264005031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264005032 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1017264005033 putative effector binding pocket; other site 1017264005034 dimerization interface [polypeptide binding]; other site 1017264005035 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1017264005036 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1017264005037 active site 1017264005038 catalytic tetrad [active] 1017264005039 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1017264005040 homotrimer interaction site [polypeptide binding]; other site 1017264005041 putative active site [active] 1017264005042 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1017264005043 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1017264005044 generic binding surface II; other site 1017264005045 ssDNA binding site; other site 1017264005046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1017264005047 ATP binding site [chemical binding]; other site 1017264005048 putative Mg++ binding site [ion binding]; other site 1017264005049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1017264005050 nucleotide binding region [chemical binding]; other site 1017264005051 ATP-binding site [chemical binding]; other site 1017264005052 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1017264005053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264005054 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1017264005055 dimerization interface [polypeptide binding]; other site 1017264005056 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264005057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264005058 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1017264005059 putative effector binding pocket; other site 1017264005060 dimerization interface [polypeptide binding]; other site 1017264005061 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1017264005062 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1017264005063 tetrameric interface [polypeptide binding]; other site 1017264005064 NAD binding site [chemical binding]; other site 1017264005065 catalytic residues [active] 1017264005066 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1017264005067 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1017264005068 dimerization interface [polypeptide binding]; other site 1017264005069 DPS ferroxidase diiron center [ion binding]; other site 1017264005070 ion pore; other site 1017264005071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1017264005072 TPR motif; other site 1017264005073 binding surface 1017264005074 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1017264005075 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1017264005076 active site 1017264005077 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1017264005078 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1017264005079 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1017264005080 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1017264005081 Walker A/P-loop; other site 1017264005082 ATP binding site [chemical binding]; other site 1017264005083 Q-loop/lid; other site 1017264005084 ABC transporter signature motif; other site 1017264005085 Walker B; other site 1017264005086 D-loop; other site 1017264005087 H-loop/switch region; other site 1017264005088 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 1017264005089 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15179 1017264005090 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1017264005091 Vi polysaccharide biosynthesis protein TviD; Provisional; Region: PRK15180 1017264005092 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1017264005093 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1017264005094 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1017264005095 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1017264005096 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1017264005097 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 1017264005098 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 1017264005099 NAD binding site [chemical binding]; other site 1017264005100 substrate binding site [chemical binding]; other site 1017264005101 homodimer interface [polypeptide binding]; other site 1017264005102 active site 1017264005103 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1017264005104 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1017264005105 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005106 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005107 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005108 Integrase core domain; Region: rve; pfam00665 1017264005109 Integrase core domain; Region: rve_3; pfam13683 1017264005110 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1017264005111 Sulfatase; Region: Sulfatase; pfam00884 1017264005112 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1017264005113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1017264005114 motif II; other site 1017264005115 Oxygen tolerance; Region: BatD; pfam13584 1017264005116 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1017264005117 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1017264005118 metal ion-dependent adhesion site (MIDAS); other site 1017264005119 Protein of unknown function DUF58; Region: DUF58; pfam01882 1017264005120 MoxR-like ATPases [General function prediction only]; Region: COG0714 1017264005121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264005122 Walker A motif; other site 1017264005123 ATP binding site [chemical binding]; other site 1017264005124 Walker B motif; other site 1017264005125 arginine finger; other site 1017264005126 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1017264005127 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264005128 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1017264005129 classical (c) SDRs; Region: SDR_c; cd05233 1017264005130 NAD(P) binding site [chemical binding]; other site 1017264005131 active site 1017264005132 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1017264005133 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005134 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005135 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005136 Integrase core domain; Region: rve; pfam00665 1017264005137 Integrase core domain; Region: rve_3; pfam13683 1017264005138 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1017264005139 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264005140 Walker A/P-loop; other site 1017264005141 ATP binding site [chemical binding]; other site 1017264005142 Q-loop/lid; other site 1017264005143 ABC transporter signature motif; other site 1017264005144 Walker B; other site 1017264005145 D-loop; other site 1017264005146 H-loop/switch region; other site 1017264005147 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1017264005148 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1017264005149 Walker A/P-loop; other site 1017264005150 ATP binding site [chemical binding]; other site 1017264005151 Q-loop/lid; other site 1017264005152 ABC transporter signature motif; other site 1017264005153 Walker B; other site 1017264005154 D-loop; other site 1017264005155 H-loop/switch region; other site 1017264005156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264005157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264005158 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1017264005159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1017264005160 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005161 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005162 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005163 Integrase core domain; Region: rve; pfam00665 1017264005164 Integrase core domain; Region: rve_3; pfam13683 1017264005165 Sulfatase; Region: Sulfatase; cl17466 1017264005166 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1017264005167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264005168 NAD(P) binding site [chemical binding]; other site 1017264005169 active site 1017264005170 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005171 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005172 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005173 Integrase core domain; Region: rve; pfam00665 1017264005174 Integrase core domain; Region: rve_3; pfam13683 1017264005175 Histidine kinase; Region: HisKA_3; pfam07730 1017264005176 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1017264005177 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1017264005178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264005179 active site 1017264005180 phosphorylation site [posttranslational modification] 1017264005181 intermolecular recognition site; other site 1017264005182 dimerization interface [polypeptide binding]; other site 1017264005183 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1017264005184 DNA binding residues [nucleotide binding] 1017264005185 dimerization interface [polypeptide binding]; other site 1017264005186 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1017264005187 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1017264005188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1017264005189 non-specific DNA binding site [nucleotide binding]; other site 1017264005190 salt bridge; other site 1017264005191 sequence-specific DNA binding site [nucleotide binding]; other site 1017264005192 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1017264005193 glutathionine S-transferase; Provisional; Region: PRK10542 1017264005194 C-terminal domain interface [polypeptide binding]; other site 1017264005195 GSH binding site (G-site) [chemical binding]; other site 1017264005196 dimer interface [polypeptide binding]; other site 1017264005197 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1017264005198 dimer interface [polypeptide binding]; other site 1017264005199 N-terminal domain interface [polypeptide binding]; other site 1017264005200 substrate binding pocket (H-site) [chemical binding]; other site 1017264005201 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1017264005202 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1017264005203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264005204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264005205 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1017264005206 dimerization interface [polypeptide binding]; other site 1017264005207 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264005208 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1017264005209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264005210 NAD(P) binding site [chemical binding]; other site 1017264005211 active site 1017264005212 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1017264005213 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1017264005214 phosphate binding site [ion binding]; other site 1017264005215 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1017264005216 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1017264005217 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1017264005218 classical (c) SDRs; Region: SDR_c; cd05233 1017264005219 NAD(P) binding site [chemical binding]; other site 1017264005220 active site 1017264005221 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1017264005222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264005223 NAD(P) binding site [chemical binding]; other site 1017264005224 active site 1017264005225 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264005226 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264005227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264005228 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264005229 dimerization interface [polypeptide binding]; other site 1017264005230 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264005231 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1017264005232 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1017264005233 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1017264005234 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264005235 putative DNA binding site [nucleotide binding]; other site 1017264005236 putative Zn2+ binding site [ion binding]; other site 1017264005237 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264005238 dihydropteridine reductase (DHPR), classical (c) SDRs; Region: DHPR_SDR_c_like; cd05334 1017264005239 NAD binding site [chemical binding]; other site 1017264005240 homodimer interface [polypeptide binding]; other site 1017264005241 active site 1017264005242 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264005243 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264005244 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1017264005245 dimerization interface [polypeptide binding]; other site 1017264005246 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005247 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005248 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005249 Integrase core domain; Region: rve; pfam00665 1017264005250 Integrase core domain; Region: rve_3; pfam13683 1017264005251 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1017264005252 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1017264005253 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1017264005254 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1017264005255 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1017264005256 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1017264005257 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1017264005258 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1017264005259 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1017264005260 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 1017264005261 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005262 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005263 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005264 Integrase core domain; Region: rve; pfam00665 1017264005265 Integrase core domain; Region: rve_3; pfam13683 1017264005266 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1017264005267 nucleoside/Zn binding site; other site 1017264005268 dimer interface [polypeptide binding]; other site 1017264005269 catalytic motif [active] 1017264005270 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1017264005271 dimer interface [polypeptide binding]; other site 1017264005272 catalytic triad [active] 1017264005273 enoyl-CoA hydratase; Provisional; Region: PRK05995 1017264005274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264005275 substrate binding site [chemical binding]; other site 1017264005276 oxyanion hole (OAH) forming residues; other site 1017264005277 trimer interface [polypeptide binding]; other site 1017264005278 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1017264005279 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1017264005280 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 1017264005281 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1017264005282 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1017264005283 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1017264005284 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1017264005285 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1017264005286 ABC transporter; Region: ABC_tran_2; pfam12848 1017264005287 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1017264005288 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1017264005289 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1017264005290 Walker A/P-loop; other site 1017264005291 ATP binding site [chemical binding]; other site 1017264005292 Q-loop/lid; other site 1017264005293 ABC transporter signature motif; other site 1017264005294 Walker B; other site 1017264005295 D-loop; other site 1017264005296 H-loop/switch region; other site 1017264005297 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1017264005298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1017264005299 substrate binding pocket [chemical binding]; other site 1017264005300 membrane-bound complex binding site; other site 1017264005301 hinge residues; other site 1017264005302 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264005303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264005304 dimer interface [polypeptide binding]; other site 1017264005305 conserved gate region; other site 1017264005306 putative PBP binding loops; other site 1017264005307 ABC-ATPase subunit interface; other site 1017264005308 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005309 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005310 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005311 Integrase core domain; Region: rve; pfam00665 1017264005312 Integrase core domain; Region: rve_3; pfam13683 1017264005313 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1017264005314 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1017264005315 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1017264005316 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1017264005317 catalytic residues [active] 1017264005318 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1017264005319 UGMP family protein; Validated; Region: PRK09604 1017264005320 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264005321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264005322 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264005323 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1017264005324 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1017264005325 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1017264005326 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1017264005327 S-adenosylmethionine binding site [chemical binding]; other site 1017264005328 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1017264005329 Peptidase family M23; Region: Peptidase_M23; pfam01551 1017264005330 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 1017264005331 active site 1017264005332 catalytic site [active] 1017264005333 substrate binding site [chemical binding]; other site 1017264005334 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 1017264005335 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1017264005336 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1017264005337 TRAM domain; Region: TRAM; cl01282 1017264005338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264005339 S-adenosylmethionine binding site [chemical binding]; other site 1017264005340 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1017264005341 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1017264005342 DNA binding residues [nucleotide binding] 1017264005343 dimer interface [polypeptide binding]; other site 1017264005344 copper binding site [ion binding]; other site 1017264005345 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 1017264005346 metal-binding site [ion binding] 1017264005347 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1017264005348 catalytic triad [active] 1017264005349 dimer interface [polypeptide binding]; other site 1017264005350 Glutaredoxin-family domain; Region: GlrX-dom; TIGR02190 1017264005351 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1017264005352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1017264005353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1017264005354 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1017264005355 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1017264005356 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1017264005357 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1017264005358 putative active site [active] 1017264005359 catalytic site [active] 1017264005360 putative metal binding site [ion binding]; other site 1017264005361 SurA N-terminal domain; Region: SurA_N_3; cl07813 1017264005362 periplasmic folding chaperone; Provisional; Region: PRK10788 1017264005363 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1017264005364 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1017264005365 active site 1017264005366 catalytic triad [active] 1017264005367 oxyanion hole [active] 1017264005368 switch loop; other site 1017264005369 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005370 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005371 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005372 Integrase core domain; Region: rve; pfam00665 1017264005373 Integrase core domain; Region: rve_3; pfam13683 1017264005374 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1017264005375 CsbD-like; Region: CsbD; cl17424 1017264005376 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 1017264005377 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1017264005378 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1017264005379 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1017264005380 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 1017264005381 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1017264005382 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1017264005383 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1017264005384 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 1017264005385 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1017264005386 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1017264005387 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1017264005388 dinuclear metal binding motif [ion binding]; other site 1017264005389 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1017264005390 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1017264005391 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1017264005392 catalytic residue [active] 1017264005393 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1017264005394 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 1017264005395 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005396 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005397 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005398 Integrase core domain; Region: rve; pfam00665 1017264005399 Integrase core domain; Region: rve_3; pfam13683 1017264005400 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1017264005401 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1017264005402 putative DNA binding site [nucleotide binding]; other site 1017264005403 putative Zn2+ binding site [ion binding]; other site 1017264005404 AsnC family; Region: AsnC_trans_reg; pfam01037 1017264005405 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 1017264005406 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1017264005407 Flavoprotein; Region: Flavoprotein; pfam02441 1017264005408 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1017264005409 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1017264005410 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1017264005411 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1017264005412 active site 1017264005413 HIGH motif; other site 1017264005414 nucleotide binding site [chemical binding]; other site 1017264005415 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1017264005416 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1017264005417 active site 1017264005418 KMSKS motif; other site 1017264005419 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1017264005420 tRNA binding surface [nucleotide binding]; other site 1017264005421 anticodon binding site; other site 1017264005422 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1017264005423 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1017264005424 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1017264005425 active site 1017264005426 Riboflavin kinase; Region: Flavokinase; smart00904 1017264005427 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1017264005428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264005429 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005430 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005431 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005432 Integrase core domain; Region: rve; pfam00665 1017264005433 Integrase core domain; Region: rve_3; pfam13683 1017264005434 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1017264005435 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1017264005436 Di-iron ligands [ion binding]; other site 1017264005437 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1017264005438 Part of AAA domain; Region: AAA_19; pfam13245 1017264005439 Family description; Region: UvrD_C_2; pfam13538 1017264005440 Secretin and TonB N terminus short domain; Region: STN; smart00965 1017264005441 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1017264005442 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1017264005443 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1017264005444 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1017264005445 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1017264005446 ABC transporter; Region: ABC_tran_2; pfam12848 1017264005447 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1017264005448 HemK family putative methylases; Region: hemK_fam; TIGR00536 1017264005449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264005450 S-adenosylmethionine binding site [chemical binding]; other site 1017264005451 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1017264005452 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1017264005453 metal binding site [ion binding]; metal-binding site 1017264005454 dimer interface [polypeptide binding]; other site 1017264005455 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1017264005456 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1017264005457 trimer interface [polypeptide binding]; other site 1017264005458 active site 1017264005459 substrate binding site [chemical binding]; other site 1017264005460 CoA binding site [chemical binding]; other site 1017264005461 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1017264005462 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1017264005463 DNA-binding site [nucleotide binding]; DNA binding site 1017264005464 RNA-binding motif; other site 1017264005465 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1017264005466 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1017264005467 DNA-binding site [nucleotide binding]; DNA binding site 1017264005468 RNA-binding motif; other site 1017264005469 hypothetical protein; Provisional; Region: PRK05208 1017264005470 trigger factor; Provisional; Region: tig; PRK01490 1017264005471 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1017264005472 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1017264005473 Clp protease; Region: CLP_protease; pfam00574 1017264005474 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1017264005475 oligomer interface [polypeptide binding]; other site 1017264005476 active site residues [active] 1017264005477 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1017264005478 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1017264005479 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1017264005480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264005481 Walker A motif; other site 1017264005482 ATP binding site [chemical binding]; other site 1017264005483 Walker B motif; other site 1017264005484 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1017264005485 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1017264005486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264005487 Walker A motif; other site 1017264005488 ATP binding site [chemical binding]; other site 1017264005489 Walker B motif; other site 1017264005490 arginine finger; other site 1017264005491 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1017264005492 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1017264005493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264005494 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1017264005495 dimerization interface [polypeptide binding]; other site 1017264005496 substrate binding pocket [chemical binding]; other site 1017264005497 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264005498 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264005499 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264005500 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1017264005501 putative active site [active] 1017264005502 putative catalytic site [active] 1017264005503 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1017264005504 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264005505 substrate binding site [chemical binding]; other site 1017264005506 oxyanion hole (OAH) forming residues; other site 1017264005507 trimer interface [polypeptide binding]; other site 1017264005508 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1017264005509 DUF35 OB-fold domain; Region: DUF35; pfam01796 1017264005510 thiolase; Provisional; Region: PRK06158 1017264005511 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1017264005512 active site 1017264005513 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1017264005514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264005515 NAD(P) binding site [chemical binding]; other site 1017264005516 active site 1017264005517 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 1017264005518 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1017264005519 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005520 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005521 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005522 Integrase core domain; Region: rve; pfam00665 1017264005523 Integrase core domain; Region: rve_3; pfam13683 1017264005524 LexA repressor; Validated; Region: PRK00215 1017264005525 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1017264005526 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1017264005527 Catalytic site [active] 1017264005528 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1017264005529 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264005530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264005531 homodimer interface [polypeptide binding]; other site 1017264005532 catalytic residue [active] 1017264005533 excinuclease ABC subunit B; Provisional; Region: PRK05298 1017264005534 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1017264005535 ATP binding site [chemical binding]; other site 1017264005536 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1017264005537 nucleotide binding region [chemical binding]; other site 1017264005538 ATP-binding site [chemical binding]; other site 1017264005539 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1017264005540 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1017264005541 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1017264005542 active site 1017264005543 Predicted transcriptional regulator [Transcription]; Region: COG1959 1017264005544 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 1017264005545 cysteine desulfurase; Provisional; Region: PRK14012 1017264005546 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1017264005547 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1017264005548 catalytic residue [active] 1017264005549 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1017264005550 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1017264005551 trimerization site [polypeptide binding]; other site 1017264005552 active site 1017264005553 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1017264005554 co-chaperone HscB; Provisional; Region: hscB; PRK03578 1017264005555 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1017264005556 HSP70 interaction site [polypeptide binding]; other site 1017264005557 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1017264005558 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1017264005559 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1017264005560 nucleotide binding site [chemical binding]; other site 1017264005561 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1017264005562 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264005563 catalytic loop [active] 1017264005564 iron binding site [ion binding]; other site 1017264005565 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 1017264005566 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1017264005567 active site 1017264005568 dimer interfaces [polypeptide binding]; other site 1017264005569 catalytic residues [active] 1017264005570 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005571 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005572 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005573 Integrase core domain; Region: rve; pfam00665 1017264005574 Integrase core domain; Region: rve_3; pfam13683 1017264005575 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1017264005576 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264005577 substrate binding site [chemical binding]; other site 1017264005578 oxyanion hole (OAH) forming residues; other site 1017264005579 trimer interface [polypeptide binding]; other site 1017264005580 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1017264005581 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005582 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005583 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005584 Integrase core domain; Region: rve; pfam00665 1017264005585 Integrase core domain; Region: rve_3; pfam13683 1017264005586 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005587 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005588 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005589 Integrase core domain; Region: rve; pfam00665 1017264005590 Integrase core domain; Region: rve_3; pfam13683 1017264005591 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 1017264005592 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1017264005593 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1017264005594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264005595 DNA-binding site [nucleotide binding]; DNA binding site 1017264005596 UTRA domain; Region: UTRA; pfam07702 1017264005597 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1017264005598 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1017264005599 MOSC domain; Region: MOSC; pfam03473 1017264005600 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1017264005601 tetramerization interface [polypeptide binding]; other site 1017264005602 active site 1017264005603 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1017264005604 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264005605 catalytic loop [active] 1017264005606 iron binding site [ion binding]; other site 1017264005607 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1017264005608 FAD binding pocket [chemical binding]; other site 1017264005609 FAD binding motif [chemical binding]; other site 1017264005610 phosphate binding motif [ion binding]; other site 1017264005611 beta-alpha-beta structure motif; other site 1017264005612 NAD binding pocket [chemical binding]; other site 1017264005613 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1017264005614 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1017264005615 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1017264005616 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1017264005617 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1017264005618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264005619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264005620 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1017264005621 putative dimerization interface [polypeptide binding]; other site 1017264005622 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1017264005623 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1017264005624 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1017264005625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264005626 dimer interface [polypeptide binding]; other site 1017264005627 conserved gate region; other site 1017264005628 putative PBP binding loops; other site 1017264005629 ABC-ATPase subunit interface; other site 1017264005630 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1017264005631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264005632 dimer interface [polypeptide binding]; other site 1017264005633 conserved gate region; other site 1017264005634 putative PBP binding loops; other site 1017264005635 ABC-ATPase subunit interface; other site 1017264005636 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1017264005637 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264005638 Walker A/P-loop; other site 1017264005639 ATP binding site [chemical binding]; other site 1017264005640 Q-loop/lid; other site 1017264005641 ABC transporter signature motif; other site 1017264005642 Walker B; other site 1017264005643 D-loop; other site 1017264005644 H-loop/switch region; other site 1017264005645 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1017264005646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264005647 Walker A/P-loop; other site 1017264005648 ATP binding site [chemical binding]; other site 1017264005649 Q-loop/lid; other site 1017264005650 ABC transporter signature motif; other site 1017264005651 Walker B; other site 1017264005652 D-loop; other site 1017264005653 H-loop/switch region; other site 1017264005654 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1017264005655 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1017264005656 Amidase; Region: Amidase; pfam01425 1017264005657 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 1017264005658 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1017264005659 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1017264005660 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1017264005661 motif 1; other site 1017264005662 active site 1017264005663 motif 2; other site 1017264005664 motif 3; other site 1017264005665 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1017264005666 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1017264005667 CPxP motif; other site 1017264005668 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1017264005669 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1017264005670 RimM N-terminal domain; Region: RimM; pfam01782 1017264005671 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1017264005672 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1017264005673 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1017264005674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1017264005675 catalytic residue [active] 1017264005676 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1017264005677 homotrimer interaction site [polypeptide binding]; other site 1017264005678 putative active site [active] 1017264005679 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005680 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005681 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005682 Integrase core domain; Region: rve; pfam00665 1017264005683 Integrase core domain; Region: rve_3; pfam13683 1017264005684 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1017264005685 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1017264005686 YceG-like family; Region: YceG; pfam02618 1017264005687 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1017264005688 dimerization interface [polypeptide binding]; other site 1017264005689 thymidylate kinase; Validated; Region: tmk; PRK00698 1017264005690 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1017264005691 TMP-binding site; other site 1017264005692 ATP-binding site [chemical binding]; other site 1017264005693 DNA polymerase III subunit delta'; Validated; Region: PRK06964 1017264005694 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1017264005695 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1017264005696 active site 1017264005697 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 1017264005698 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1017264005699 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1017264005700 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264005701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264005702 putative DNA binding site [nucleotide binding]; other site 1017264005703 putative Zn2+ binding site [ion binding]; other site 1017264005704 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264005705 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264005706 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1017264005707 substrate binding pocket [chemical binding]; other site 1017264005708 membrane-bound complex binding site; other site 1017264005709 hinge residues; other site 1017264005710 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1017264005711 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1017264005712 Walker A/P-loop; other site 1017264005713 ATP binding site [chemical binding]; other site 1017264005714 Q-loop/lid; other site 1017264005715 ABC transporter signature motif; other site 1017264005716 Walker B; other site 1017264005717 D-loop; other site 1017264005718 H-loop/switch region; other site 1017264005719 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1017264005720 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1017264005721 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1017264005722 NAD(P) binding site [chemical binding]; other site 1017264005723 allantoate amidohydrolase; Reviewed; Region: PRK12893 1017264005724 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1017264005725 active site 1017264005726 metal binding site [ion binding]; metal-binding site 1017264005727 dimer interface [polypeptide binding]; other site 1017264005728 thiamine pyrophosphate protein; Validated; Region: PRK08199 1017264005729 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1017264005730 PYR/PP interface [polypeptide binding]; other site 1017264005731 dimer interface [polypeptide binding]; other site 1017264005732 TPP binding site [chemical binding]; other site 1017264005733 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1017264005734 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1017264005735 TPP-binding site [chemical binding]; other site 1017264005736 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1017264005737 DctM-like transporters; Region: DctM; pfam06808 1017264005738 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1017264005739 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1017264005740 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1017264005741 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1017264005742 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1017264005743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264005744 DNA-binding site [nucleotide binding]; DNA binding site 1017264005745 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1017264005746 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005747 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005748 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005749 Integrase core domain; Region: rve; pfam00665 1017264005750 Integrase core domain; Region: rve_3; pfam13683 1017264005751 amidase; Provisional; Region: PRK07056 1017264005752 Amidase; Region: Amidase; cl11426 1017264005753 hypothetical protein; Provisional; Region: PRK05463 1017264005754 EAL domain; Region: EAL; pfam00563 1017264005755 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1017264005756 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264005757 substrate binding pocket [chemical binding]; other site 1017264005758 membrane-bound complex binding site; other site 1017264005759 hinge residues; other site 1017264005760 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264005761 substrate binding pocket [chemical binding]; other site 1017264005762 membrane-bound complex binding site; other site 1017264005763 hinge residues; other site 1017264005764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1017264005765 putative active site [active] 1017264005766 heme pocket [chemical binding]; other site 1017264005767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264005768 dimer interface [polypeptide binding]; other site 1017264005769 phosphorylation site [posttranslational modification] 1017264005770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264005771 ATP binding site [chemical binding]; other site 1017264005772 Mg2+ binding site [ion binding]; other site 1017264005773 G-X-G motif; other site 1017264005774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264005775 active site 1017264005776 phosphorylation site [posttranslational modification] 1017264005777 intermolecular recognition site; other site 1017264005778 dimerization interface [polypeptide binding]; other site 1017264005779 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1017264005780 putative binding surface; other site 1017264005781 active site 1017264005782 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1017264005783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264005784 active site 1017264005785 phosphorylation site [posttranslational modification] 1017264005786 intermolecular recognition site; other site 1017264005787 dimerization interface [polypeptide binding]; other site 1017264005788 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1017264005789 DNA binding residues [nucleotide binding] 1017264005790 dimerization interface [polypeptide binding]; other site 1017264005791 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1017264005792 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1017264005793 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1017264005794 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1017264005795 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1017264005796 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1017264005797 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1017264005798 PapC N-terminal domain; Region: PapC_N; pfam13954 1017264005799 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1017264005800 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1017264005801 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1017264005802 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1017264005803 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1017264005804 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1017264005805 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1017264005806 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1017264005807 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1017264005808 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1017264005809 MarR family; Region: MarR_2; cl17246 1017264005810 5-oxoprolinase; Region: PLN02666 1017264005811 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1017264005812 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1017264005813 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1017264005814 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1017264005815 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1017264005816 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1017264005817 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264005818 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1017264005819 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264005820 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264005821 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1017264005822 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1017264005823 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1017264005824 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1017264005825 active site 1017264005826 dimerization interface [polypeptide binding]; other site 1017264005827 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1017264005828 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1017264005829 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1017264005830 Transporter associated domain; Region: CorC_HlyC; smart01091 1017264005831 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1017264005832 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1017264005833 putative active site [active] 1017264005834 putative metal binding site [ion binding]; other site 1017264005835 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1017264005836 substrate binding site [chemical binding]; other site 1017264005837 TPR repeat; Region: TPR_11; pfam13414 1017264005838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1017264005839 binding surface 1017264005840 TPR motif; other site 1017264005841 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1017264005842 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1017264005843 active site 1017264005844 HIGH motif; other site 1017264005845 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1017264005846 KMSKS motif; other site 1017264005847 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1017264005848 tRNA binding surface [nucleotide binding]; other site 1017264005849 anticodon binding site; other site 1017264005850 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1017264005851 endonuclease III; Region: ENDO3c; smart00478 1017264005852 minor groove reading motif; other site 1017264005853 helix-hairpin-helix signature motif; other site 1017264005854 substrate binding pocket [chemical binding]; other site 1017264005855 active site 1017264005856 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1017264005857 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1017264005858 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005859 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005860 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005861 Integrase core domain; Region: rve; pfam00665 1017264005862 Integrase core domain; Region: rve_3; pfam13683 1017264005863 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1017264005864 TilS substrate binding domain; Region: TilS; pfam09179 1017264005865 aspartate kinase; Reviewed; Region: PRK06635 1017264005866 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1017264005867 putative nucleotide binding site [chemical binding]; other site 1017264005868 putative catalytic residues [active] 1017264005869 putative Mg ion binding site [ion binding]; other site 1017264005870 putative aspartate binding site [chemical binding]; other site 1017264005871 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1017264005872 putative allosteric regulatory site; other site 1017264005873 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1017264005874 putative allosteric regulatory residue; other site 1017264005875 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264005876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264005877 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264005878 Cupin domain; Region: Cupin_2; pfam07883 1017264005879 NIPSNAP; Region: NIPSNAP; pfam07978 1017264005880 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 1017264005881 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1017264005882 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1017264005883 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1017264005884 DctM-like transporters; Region: DctM; pfam06808 1017264005885 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1017264005886 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1017264005887 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1017264005888 pyrimidine utilization protein D; Region: RutD; TIGR03611 1017264005889 putative L-aspartate dehydrogenase; Provisional; Region: PRK13301 1017264005890 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1017264005891 Domain of unknown function DUF108; Region: DUF108; pfam01958 1017264005892 short chain dehydrogenase; Provisional; Region: PRK06138 1017264005893 classical (c) SDRs; Region: SDR_c; cd05233 1017264005894 NAD(P) binding site [chemical binding]; other site 1017264005895 active site 1017264005896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264005897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264005898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264005899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264005900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264005901 dimerization interface [polypeptide binding]; other site 1017264005902 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1017264005903 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1017264005904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264005905 dimer interface [polypeptide binding]; other site 1017264005906 conserved gate region; other site 1017264005907 putative PBP binding loops; other site 1017264005908 ABC-ATPase subunit interface; other site 1017264005909 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1017264005910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264005911 dimer interface [polypeptide binding]; other site 1017264005912 conserved gate region; other site 1017264005913 putative PBP binding loops; other site 1017264005914 ABC-ATPase subunit interface; other site 1017264005915 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1017264005916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264005917 Walker A/P-loop; other site 1017264005918 ATP binding site [chemical binding]; other site 1017264005919 Q-loop/lid; other site 1017264005920 ABC transporter signature motif; other site 1017264005921 Walker B; other site 1017264005922 D-loop; other site 1017264005923 H-loop/switch region; other site 1017264005924 TOBE domain; Region: TOBE_2; pfam08402 1017264005925 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1017264005926 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1017264005927 active site 1017264005928 FMN binding site [chemical binding]; other site 1017264005929 substrate binding site [chemical binding]; other site 1017264005930 putative catalytic residue [active] 1017264005931 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1017264005932 CoA binding domain; Region: CoA_binding_2; pfam13380 1017264005933 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1017264005934 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1017264005935 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264005936 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1017264005937 homotrimer interaction site [polypeptide binding]; other site 1017264005938 putative active site [active] 1017264005939 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1017264005940 active site 2 [active] 1017264005941 active site 1 [active] 1017264005942 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1017264005943 active site 1017264005944 catalytic site [active] 1017264005945 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1017264005946 active site 2 [active] 1017264005947 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264005948 dimerization interface [polypeptide binding]; other site 1017264005949 putative DNA binding site [nucleotide binding]; other site 1017264005950 putative Zn2+ binding site [ion binding]; other site 1017264005951 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1017264005952 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1017264005953 FMN binding site [chemical binding]; other site 1017264005954 active site 1017264005955 substrate binding site [chemical binding]; other site 1017264005956 catalytic residue [active] 1017264005957 N-glycosyltransferase; Provisional; Region: PRK11204 1017264005958 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1017264005959 DXD motif; other site 1017264005960 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 1017264005961 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1017264005962 putative active site [active] 1017264005963 putative metal binding site [ion binding]; other site 1017264005964 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1017264005965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1017264005966 TPR motif; other site 1017264005967 TPR repeat; Region: TPR_11; pfam13414 1017264005968 binding surface 1017264005969 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1017264005970 MarR family; Region: MarR_2; cl17246 1017264005971 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1017264005972 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264005973 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264005974 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264005975 Integrase core domain; Region: rve; pfam00665 1017264005976 Integrase core domain; Region: rve_3; pfam13683 1017264005977 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1017264005978 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 1017264005979 putative ligand binding site [chemical binding]; other site 1017264005980 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264005981 TM-ABC transporter signature motif; other site 1017264005982 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1017264005983 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1017264005984 TM-ABC transporter signature motif; other site 1017264005985 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1017264005986 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264005987 Walker A/P-loop; other site 1017264005988 ATP binding site [chemical binding]; other site 1017264005989 Q-loop/lid; other site 1017264005990 ABC transporter signature motif; other site 1017264005991 Walker B; other site 1017264005992 D-loop; other site 1017264005993 H-loop/switch region; other site 1017264005994 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1017264005995 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1017264005996 Walker A/P-loop; other site 1017264005997 ATP binding site [chemical binding]; other site 1017264005998 Q-loop/lid; other site 1017264005999 ABC transporter signature motif; other site 1017264006000 Walker B; other site 1017264006001 D-loop; other site 1017264006002 H-loop/switch region; other site 1017264006003 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 1017264006004 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264006005 catalytic loop [active] 1017264006006 iron binding site [ion binding]; other site 1017264006007 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1017264006008 hypothetical protein; Provisional; Region: PRK06847 1017264006009 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1017264006010 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1017264006011 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1017264006012 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1017264006013 Isochorismatase family; Region: Isochorismatase; pfam00857 1017264006014 catalytic triad [active] 1017264006015 conserved cis-peptide bond; other site 1017264006016 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264006017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264006018 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264006019 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1017264006020 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1017264006021 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1017264006022 FAD binding pocket [chemical binding]; other site 1017264006023 FAD binding motif [chemical binding]; other site 1017264006024 phosphate binding motif [ion binding]; other site 1017264006025 beta-alpha-beta structure motif; other site 1017264006026 NAD binding pocket [chemical binding]; other site 1017264006027 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1017264006028 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264006029 N-terminal plug; other site 1017264006030 ligand-binding site [chemical binding]; other site 1017264006031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1017264006032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1017264006033 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1017264006034 DNA binding residues [nucleotide binding] 1017264006035 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1017264006036 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1017264006037 active site 1017264006038 substrate binding site [chemical binding]; other site 1017264006039 metal binding site [ion binding]; metal-binding site 1017264006040 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1017264006041 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1017264006042 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1017264006043 dimer interface [polypeptide binding]; other site 1017264006044 active site 1017264006045 serine O-acetyltransferase; Region: cysE; TIGR01172 1017264006046 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1017264006047 trimer interface [polypeptide binding]; other site 1017264006048 active site 1017264006049 substrate binding site [chemical binding]; other site 1017264006050 CoA binding site [chemical binding]; other site 1017264006051 NAD-dependent deacetylase; Provisional; Region: PRK05333 1017264006052 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1017264006053 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 1017264006054 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1017264006055 active site 1017264006056 putative lithium-binding site [ion binding]; other site 1017264006057 substrate binding site [chemical binding]; other site 1017264006058 succinic semialdehyde dehydrogenase; Region: PLN02278 1017264006059 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1017264006060 tetramerization interface [polypeptide binding]; other site 1017264006061 NAD(P) binding site [chemical binding]; other site 1017264006062 catalytic residues [active] 1017264006063 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1017264006064 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1017264006065 inhibitor-cofactor binding pocket; inhibition site 1017264006066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264006067 catalytic residue [active] 1017264006068 Protein of unknown function DUF72; Region: DUF72; pfam01904 1017264006069 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1017264006070 Part of AAA domain; Region: AAA_19; pfam13245 1017264006071 Family description; Region: UvrD_C_2; pfam13538 1017264006072 Staphylococcal nuclease homologues; Region: SNc; smart00318 1017264006073 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1017264006074 Catalytic site; other site 1017264006075 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 1017264006076 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1017264006077 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1017264006078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264006079 dimer interface [polypeptide binding]; other site 1017264006080 conserved gate region; other site 1017264006081 putative PBP binding loops; other site 1017264006082 ABC-ATPase subunit interface; other site 1017264006083 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1017264006084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264006085 dimer interface [polypeptide binding]; other site 1017264006086 conserved gate region; other site 1017264006087 putative PBP binding loops; other site 1017264006088 ABC-ATPase subunit interface; other site 1017264006089 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1017264006090 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264006091 Walker A/P-loop; other site 1017264006092 ATP binding site [chemical binding]; other site 1017264006093 Q-loop/lid; other site 1017264006094 ABC transporter signature motif; other site 1017264006095 Walker B; other site 1017264006096 D-loop; other site 1017264006097 H-loop/switch region; other site 1017264006098 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1017264006099 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264006100 Walker A/P-loop; other site 1017264006101 ATP binding site [chemical binding]; other site 1017264006102 Q-loop/lid; other site 1017264006103 ABC transporter signature motif; other site 1017264006104 Walker B; other site 1017264006105 D-loop; other site 1017264006106 H-loop/switch region; other site 1017264006107 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1017264006108 MarR family; Region: MarR_2; pfam12802 1017264006109 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1017264006110 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1017264006111 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1017264006112 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1017264006113 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1017264006114 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1017264006115 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1017264006116 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1017264006117 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1017264006118 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1017264006119 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1017264006120 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1017264006121 AAA domain; Region: AAA_31; pfam13614 1017264006122 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1017264006123 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1017264006124 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1017264006125 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1017264006126 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1017264006127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1017264006128 TPR motif; other site 1017264006129 binding surface 1017264006130 Predicted membrane protein [Function unknown]; Region: COG4655 1017264006131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264006132 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1017264006133 Walker A motif; other site 1017264006134 ATP binding site [chemical binding]; other site 1017264006135 Walker B motif; other site 1017264006136 arginine finger; other site 1017264006137 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1017264006138 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 1017264006139 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 1017264006140 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1017264006141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1017264006142 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1017264006143 DNA binding residues [nucleotide binding] 1017264006144 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1017264006145 dinuclear metal binding motif [ion binding]; other site 1017264006146 Cytochrome c; Region: Cytochrom_C; cl11414 1017264006147 elongation factor P; Validated; Region: PRK00529 1017264006148 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1017264006149 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1017264006150 RNA binding site [nucleotide binding]; other site 1017264006151 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1017264006152 RNA binding site [nucleotide binding]; other site 1017264006153 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 1017264006154 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 1017264006155 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1017264006156 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1017264006157 putative active site [active] 1017264006158 metal binding site [ion binding]; metal-binding site 1017264006159 aconitate hydratase; Provisional; Region: acnA; PRK12881 1017264006160 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1017264006161 substrate binding site [chemical binding]; other site 1017264006162 ligand binding site [chemical binding]; other site 1017264006163 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1017264006164 substrate binding site [chemical binding]; other site 1017264006165 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1017264006166 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1017264006167 catalytic residue [active] 1017264006168 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1017264006169 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264006170 N-terminal plug; other site 1017264006171 ligand-binding site [chemical binding]; other site 1017264006172 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1017264006173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1017264006174 motif II; other site 1017264006175 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006176 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006177 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006178 Integrase core domain; Region: rve; pfam00665 1017264006179 Integrase core domain; Region: rve_3; pfam13683 1017264006180 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1017264006181 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1017264006182 ligand binding site [chemical binding]; other site 1017264006183 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 1017264006184 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1017264006185 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1017264006186 substrate binding site [chemical binding]; other site 1017264006187 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1017264006188 substrate binding site [chemical binding]; other site 1017264006189 ligand binding site [chemical binding]; other site 1017264006190 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1017264006191 active site 1017264006192 catalytic site [active] 1017264006193 substrate binding site [chemical binding]; other site 1017264006194 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1017264006195 homodimer interface [polypeptide binding]; other site 1017264006196 chemical substrate binding site [chemical binding]; other site 1017264006197 oligomer interface [polypeptide binding]; other site 1017264006198 metal binding site [ion binding]; metal-binding site 1017264006199 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1017264006200 YciI-like protein; Reviewed; Region: PRK12866 1017264006201 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1017264006202 EamA-like transporter family; Region: EamA; pfam00892 1017264006203 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006204 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006205 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006206 Integrase core domain; Region: rve; pfam00665 1017264006207 Integrase core domain; Region: rve_3; pfam13683 1017264006208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264006209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264006210 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1017264006211 putative dimerization interface [polypeptide binding]; other site 1017264006212 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1017264006213 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1017264006214 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1017264006215 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1017264006216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264006217 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1017264006218 dimerization interface [polypeptide binding]; other site 1017264006219 substrate binding pocket [chemical binding]; other site 1017264006220 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1017264006221 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 1017264006222 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1017264006223 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1017264006224 amidase; Provisional; Region: PRK07487 1017264006225 Amidase; Region: Amidase; cl11426 1017264006226 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1017264006227 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1017264006228 putative catalytic cysteine [active] 1017264006229 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1017264006230 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1017264006231 Lipopolysaccharide-assembly; Region: LptE; pfam04390 1017264006232 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1017264006233 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1017264006234 HIGH motif; other site 1017264006235 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1017264006236 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1017264006237 active site 1017264006238 KMSKS motif; other site 1017264006239 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1017264006240 tRNA binding surface [nucleotide binding]; other site 1017264006241 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1017264006242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264006243 putative substrate translocation pore; other site 1017264006244 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1017264006245 MarR family; Region: MarR_2; cl17246 1017264006246 bacterial (prokaryotic) histone like domain; Region: BHL; smart00411 1017264006247 IHF dimer interface [polypeptide binding]; other site 1017264006248 IHF - DNA interface [nucleotide binding]; other site 1017264006249 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006250 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006251 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006252 Integrase core domain; Region: rve; pfam00665 1017264006253 Integrase core domain; Region: rve_3; pfam13683 1017264006254 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1017264006255 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1017264006256 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1017264006257 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1017264006258 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1017264006259 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1017264006260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264006261 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1017264006262 putative substrate translocation pore; other site 1017264006263 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006264 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006265 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006266 Integrase core domain; Region: rve; pfam00665 1017264006267 Integrase core domain; Region: rve_3; pfam13683 1017264006268 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1017264006269 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1017264006270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264006271 dimer interface [polypeptide binding]; other site 1017264006272 conserved gate region; other site 1017264006273 putative PBP binding loops; other site 1017264006274 ABC-ATPase subunit interface; other site 1017264006275 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1017264006276 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1017264006277 Walker A/P-loop; other site 1017264006278 ATP binding site [chemical binding]; other site 1017264006279 Q-loop/lid; other site 1017264006280 ABC transporter signature motif; other site 1017264006281 Walker B; other site 1017264006282 D-loop; other site 1017264006283 H-loop/switch region; other site 1017264006284 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1017264006285 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1017264006286 active site 1 [active] 1017264006287 dimer interface [polypeptide binding]; other site 1017264006288 hexamer interface [polypeptide binding]; other site 1017264006289 active site 2 [active] 1017264006290 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1017264006291 dimer interface [polypeptide binding]; other site 1017264006292 hexamer interface [polypeptide binding]; other site 1017264006293 active site 2 [active] 1017264006294 beta-ketothiolase; Provisional; Region: PRK09051 1017264006295 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1017264006296 dimer interface [polypeptide binding]; other site 1017264006297 active site 1017264006298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1017264006299 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1017264006300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264006301 DNA-binding site [nucleotide binding]; DNA binding site 1017264006302 FCD domain; Region: FCD; pfam07729 1017264006303 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 1017264006304 enoyl-CoA hydratase; Provisional; Region: PRK06127 1017264006305 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264006306 substrate binding site [chemical binding]; other site 1017264006307 oxyanion hole (OAH) forming residues; other site 1017264006308 trimer interface [polypeptide binding]; other site 1017264006309 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264006310 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1017264006311 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1017264006312 E-class dimer interface [polypeptide binding]; other site 1017264006313 P-class dimer interface [polypeptide binding]; other site 1017264006314 active site 1017264006315 Cu2+ binding site [ion binding]; other site 1017264006316 Zn2+ binding site [ion binding]; other site 1017264006317 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1017264006318 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1017264006319 zinc binding site [ion binding]; other site 1017264006320 putative ligand binding site [chemical binding]; other site 1017264006321 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1017264006322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264006323 Walker A/P-loop; other site 1017264006324 ATP binding site [chemical binding]; other site 1017264006325 Q-loop/lid; other site 1017264006326 ABC transporter signature motif; other site 1017264006327 Walker B; other site 1017264006328 D-loop; other site 1017264006329 H-loop/switch region; other site 1017264006330 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1017264006331 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1017264006332 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1017264006333 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1017264006334 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1017264006335 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1017264006336 Patatin phospholipase; Region: DUF3734; pfam12536 1017264006337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1017264006338 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1017264006339 DNA binding site [nucleotide binding] 1017264006340 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1017264006341 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1017264006342 HlyD family secretion protein; Region: HlyD_3; pfam13437 1017264006343 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1017264006344 Protein export membrane protein; Region: SecD_SecF; cl14618 1017264006345 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1017264006346 active site 1017264006347 hydrophilic channel; other site 1017264006348 dimerization interface [polypeptide binding]; other site 1017264006349 catalytic residues [active] 1017264006350 active site lid [active] 1017264006351 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1017264006352 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1017264006353 beta-hexosaminidase; Provisional; Region: PRK05337 1017264006354 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1017264006355 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1017264006356 GIY-YIG motif/motif A; other site 1017264006357 active site 1017264006358 catalytic site [active] 1017264006359 putative DNA binding site [nucleotide binding]; other site 1017264006360 metal binding site [ion binding]; metal-binding site 1017264006361 UvrB/uvrC motif; Region: UVR; pfam02151 1017264006362 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1017264006363 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1017264006364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1017264006365 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1017264006366 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1017264006367 isocitrate lyase; Provisional; Region: PRK15063 1017264006368 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1017264006369 tetramer interface [polypeptide binding]; other site 1017264006370 active site 1017264006371 Mg2+/Mn2+ binding site [ion binding]; other site 1017264006372 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006373 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006374 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006375 Integrase core domain; Region: rve; pfam00665 1017264006376 Integrase core domain; Region: rve_3; pfam13683 1017264006377 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1017264006378 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264006379 TM-ABC transporter signature motif; other site 1017264006380 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1017264006381 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1017264006382 putative ligand binding site [chemical binding]; other site 1017264006383 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1017264006384 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1017264006385 iron-sulfur cluster [ion binding]; other site 1017264006386 [2Fe-2S] cluster binding site [ion binding]; other site 1017264006387 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1017264006388 putative alpha subunit interface [polypeptide binding]; other site 1017264006389 putative active site [active] 1017264006390 putative substrate binding site [chemical binding]; other site 1017264006391 Fe binding site [ion binding]; other site 1017264006392 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1017264006393 inter-subunit interface; other site 1017264006394 enoyl-CoA hydratase; Provisional; Region: PRK06688 1017264006395 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264006396 substrate binding site [chemical binding]; other site 1017264006397 oxyanion hole (OAH) forming residues; other site 1017264006398 trimer interface [polypeptide binding]; other site 1017264006399 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1017264006400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264006401 NAD(P) binding site [chemical binding]; other site 1017264006402 active site 1017264006403 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1017264006404 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264006405 catalytic loop [active] 1017264006406 iron binding site [ion binding]; other site 1017264006407 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264006408 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264006409 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1017264006410 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1017264006411 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1017264006412 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1017264006413 acyl-activating enzyme (AAE) consensus motif; other site 1017264006414 AMP binding site [chemical binding]; other site 1017264006415 active site 1017264006416 CoA binding site [chemical binding]; other site 1017264006417 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 1017264006418 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1017264006419 active site 1017264006420 hypothetical protein; Provisional; Region: PRK04262 1017264006421 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1017264006422 dimer interface [polypeptide binding]; other site 1017264006423 active site 1017264006424 DUF35 OB-fold domain; Region: DUF35; pfam01796 1017264006425 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264006426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264006427 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1017264006428 putative dimerization interface [polypeptide binding]; other site 1017264006429 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264006430 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006431 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006432 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006433 Integrase core domain; Region: rve; pfam00665 1017264006434 Integrase core domain; Region: rve_3; pfam13683 1017264006435 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006436 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006437 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006438 Integrase core domain; Region: rve; pfam00665 1017264006439 Integrase core domain; Region: rve_3; pfam13683 1017264006440 Rdx family; Region: Rdx; cl01407 1017264006441 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1017264006442 apolar tunnel; other site 1017264006443 heme binding site [chemical binding]; other site 1017264006444 dimerization interface [polypeptide binding]; other site 1017264006445 NnrS protein; Region: NnrS; pfam05940 1017264006446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 1017264006447 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1017264006448 putative catalytic site [active] 1017264006449 putative phosphate binding site [ion binding]; other site 1017264006450 active site 1017264006451 metal binding site A [ion binding]; metal-binding site 1017264006452 DNA binding site [nucleotide binding] 1017264006453 putative AP binding site [nucleotide binding]; other site 1017264006454 putative metal binding site B [ion binding]; other site 1017264006455 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1017264006456 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1017264006457 MlrC C-terminus; Region: MlrC_C; pfam07171 1017264006458 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1017264006459 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1017264006460 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1017264006461 active site 1017264006462 catalytic site [active] 1017264006463 Zn binding site [ion binding]; other site 1017264006464 tetramer interface [polypeptide binding]; other site 1017264006465 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264006466 glutathione reductase; Validated; Region: PRK06116 1017264006467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1017264006468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1017264006469 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1017264006470 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264006471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264006472 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264006473 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1017264006474 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1017264006475 LysR family transcriptional regulator; Provisional; Region: PRK14997 1017264006476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264006477 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1017264006478 putative effector binding pocket; other site 1017264006479 putative dimerization interface [polypeptide binding]; other site 1017264006480 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1017264006481 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 1017264006482 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264006483 catalytic loop [active] 1017264006484 iron binding site [ion binding]; other site 1017264006485 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1017264006486 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1017264006487 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1017264006488 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1017264006489 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1017264006490 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1017264006491 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1017264006492 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1017264006493 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1017264006494 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1017264006495 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1017264006496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1017264006497 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1017264006498 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1017264006499 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1017264006500 dimer interface [polypeptide binding]; other site 1017264006501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264006502 putative substrate translocation pore; other site 1017264006503 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1017264006504 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006505 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006506 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006507 Integrase core domain; Region: rve; pfam00665 1017264006508 Integrase core domain; Region: rve_3; pfam13683 1017264006509 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006510 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006511 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006512 Integrase core domain; Region: rve; pfam00665 1017264006513 Integrase core domain; Region: rve_3; pfam13683 1017264006514 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1017264006515 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1017264006516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264006517 Walker A/P-loop; other site 1017264006518 ATP binding site [chemical binding]; other site 1017264006519 Q-loop/lid; other site 1017264006520 ABC transporter signature motif; other site 1017264006521 Walker B; other site 1017264006522 D-loop; other site 1017264006523 H-loop/switch region; other site 1017264006524 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1017264006525 ZIP Zinc transporter; Region: Zip; pfam02535 1017264006526 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1017264006527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264006528 DNA-binding site [nucleotide binding]; DNA binding site 1017264006529 FCD domain; Region: FCD; pfam07729 1017264006530 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1017264006531 putative transporter; Provisional; Region: PRK11660 1017264006532 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1017264006533 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1017264006534 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1017264006535 putative hydrophobic ligand binding site [chemical binding]; other site 1017264006536 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264006537 dimerization interface [polypeptide binding]; other site 1017264006538 putative DNA binding site [nucleotide binding]; other site 1017264006539 putative Zn2+ binding site [ion binding]; other site 1017264006540 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1017264006541 Domain of unknown function DUF302; Region: DUF302; cl01364 1017264006542 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 1017264006543 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1017264006544 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1017264006545 conserved cys residue [active] 1017264006546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1017264006547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1017264006548 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 1017264006549 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1017264006550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264006551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264006552 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264006553 dimerization interface [polypeptide binding]; other site 1017264006554 Predicted membrane protein [Function unknown]; Region: COG2733 1017264006555 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1017264006556 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1017264006557 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1017264006558 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1017264006559 NAD(P) binding site [chemical binding]; other site 1017264006560 catalytic residues [active] 1017264006561 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1017264006562 GAF domain; Region: GAF; cl17456 1017264006563 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1017264006564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264006565 Walker A motif; other site 1017264006566 ATP binding site [chemical binding]; other site 1017264006567 Walker B motif; other site 1017264006568 arginine finger; other site 1017264006569 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1017264006570 LrgA family; Region: LrgA; pfam03788 1017264006571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1017264006572 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1017264006573 AAA domain; Region: AAA_26; pfam13500 1017264006574 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1017264006575 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 1017264006576 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1017264006577 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1017264006578 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1017264006579 catalytic residue [active] 1017264006580 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1017264006581 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1017264006582 inhibitor-cofactor binding pocket; inhibition site 1017264006583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264006584 catalytic residue [active] 1017264006585 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006586 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006587 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006588 Integrase core domain; Region: rve; pfam00665 1017264006589 Integrase core domain; Region: rve_3; pfam13683 1017264006590 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1017264006591 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1017264006592 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 1017264006593 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1017264006594 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1017264006595 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 1017264006596 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1017264006597 Cytochrome c; Region: Cytochrom_C; pfam00034 1017264006598 Cytochrome c; Region: Cytochrom_C; pfam00034 1017264006599 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1017264006600 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1017264006601 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1017264006602 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1017264006603 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1017264006604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1017264006605 Coenzyme A binding pocket [chemical binding]; other site 1017264006606 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1017264006607 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1017264006608 Walker A/P-loop; other site 1017264006609 ATP binding site [chemical binding]; other site 1017264006610 Q-loop/lid; other site 1017264006611 ABC transporter signature motif; other site 1017264006612 Walker B; other site 1017264006613 D-loop; other site 1017264006614 H-loop/switch region; other site 1017264006615 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1017264006616 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1017264006617 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1017264006618 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006619 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006620 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006621 Integrase core domain; Region: rve; pfam00665 1017264006622 Integrase core domain; Region: rve_3; pfam13683 1017264006623 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1017264006624 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1017264006625 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1017264006626 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1017264006627 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1017264006628 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1017264006629 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1017264006630 DNA binding residues [nucleotide binding] 1017264006631 DNA primase, catalytic core; Region: dnaG; TIGR01391 1017264006632 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1017264006633 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1017264006634 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1017264006635 active site 1017264006636 metal binding site [ion binding]; metal-binding site 1017264006637 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1017264006638 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1017264006639 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1017264006640 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1017264006641 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1017264006642 active site 1017264006643 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1017264006644 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1017264006645 GDP-binding site [chemical binding]; other site 1017264006646 ACT binding site; other site 1017264006647 IMP binding site; other site 1017264006648 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1017264006649 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1017264006650 dimer interface [polypeptide binding]; other site 1017264006651 motif 1; other site 1017264006652 active site 1017264006653 motif 2; other site 1017264006654 motif 3; other site 1017264006655 HflC protein; Region: hflC; TIGR01932 1017264006656 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1017264006657 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1017264006658 HflK protein; Region: hflK; TIGR01933 1017264006659 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1017264006660 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1017264006661 HflX GTPase family; Region: HflX; cd01878 1017264006662 G1 box; other site 1017264006663 GTP/Mg2+ binding site [chemical binding]; other site 1017264006664 Switch I region; other site 1017264006665 G2 box; other site 1017264006666 G3 box; other site 1017264006667 Switch II region; other site 1017264006668 G4 box; other site 1017264006669 G5 box; other site 1017264006670 bacterial Hfq-like; Region: Hfq; cd01716 1017264006671 hexamer interface [polypeptide binding]; other site 1017264006672 Sm1 motif; other site 1017264006673 RNA binding site [nucleotide binding]; other site 1017264006674 Sm2 motif; other site 1017264006675 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1017264006676 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264006677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264006678 homodimer interface [polypeptide binding]; other site 1017264006679 catalytic residue [active] 1017264006680 GTP-binding protein Der; Reviewed; Region: PRK00093 1017264006681 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1017264006682 G1 box; other site 1017264006683 GTP/Mg2+ binding site [chemical binding]; other site 1017264006684 Switch I region; other site 1017264006685 G2 box; other site 1017264006686 Switch II region; other site 1017264006687 G3 box; other site 1017264006688 G4 box; other site 1017264006689 G5 box; other site 1017264006690 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1017264006691 G1 box; other site 1017264006692 GTP/Mg2+ binding site [chemical binding]; other site 1017264006693 Switch I region; other site 1017264006694 G2 box; other site 1017264006695 G3 box; other site 1017264006696 Switch II region; other site 1017264006697 G4 box; other site 1017264006698 G5 box; other site 1017264006699 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1017264006700 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1017264006701 Trp docking motif [polypeptide binding]; other site 1017264006702 active site 1017264006703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1017264006704 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1017264006705 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1017264006706 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1017264006707 dimer interface [polypeptide binding]; other site 1017264006708 motif 1; other site 1017264006709 active site 1017264006710 motif 2; other site 1017264006711 motif 3; other site 1017264006712 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1017264006713 anticodon binding site; other site 1017264006714 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1017264006715 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1017264006716 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1017264006717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1017264006718 non-specific DNA binding site [nucleotide binding]; other site 1017264006719 salt bridge; other site 1017264006720 sequence-specific DNA binding site [nucleotide binding]; other site 1017264006721 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1017264006722 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1017264006723 active site 1017264006724 multimer interface [polypeptide binding]; other site 1017264006725 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1017264006726 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1017264006727 active site 1017264006728 HIGH motif; other site 1017264006729 nucleotide binding site [chemical binding]; other site 1017264006730 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1017264006731 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1017264006732 active site 1017264006733 KMSKS motif; other site 1017264006734 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1017264006735 tRNA binding surface [nucleotide binding]; other site 1017264006736 anticodon binding site; other site 1017264006737 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1017264006738 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1017264006739 sensor protein QseC; Provisional; Region: PRK10337 1017264006740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264006741 dimer interface [polypeptide binding]; other site 1017264006742 phosphorylation site [posttranslational modification] 1017264006743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264006744 ATP binding site [chemical binding]; other site 1017264006745 Mg2+ binding site [ion binding]; other site 1017264006746 G-X-G motif; other site 1017264006747 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006748 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006749 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006750 Integrase core domain; Region: rve; pfam00665 1017264006751 Integrase core domain; Region: rve_3; pfam13683 1017264006752 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1017264006753 Predicted transcriptional regulator [Transcription]; Region: COG1959 1017264006754 Transcriptional regulator; Region: Rrf2; cl17282 1017264006755 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1017264006756 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1017264006757 heme-binding site [chemical binding]; other site 1017264006758 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1017264006759 FAD binding pocket [chemical binding]; other site 1017264006760 FAD binding motif [chemical binding]; other site 1017264006761 phosphate binding motif [ion binding]; other site 1017264006762 beta-alpha-beta structure motif; other site 1017264006763 NAD binding pocket [chemical binding]; other site 1017264006764 Heme binding pocket [chemical binding]; other site 1017264006765 Yqey-like protein; Region: YqeY; pfam09424 1017264006766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1017264006767 Coenzyme A binding pocket [chemical binding]; other site 1017264006768 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1017264006769 MarR family; Region: MarR; pfam01047 1017264006770 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1017264006771 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1017264006772 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1017264006773 putative active site [active] 1017264006774 hypothetical protein; Provisional; Region: PRK07483 1017264006775 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1017264006776 inhibitor-cofactor binding pocket; inhibition site 1017264006777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264006778 catalytic residue [active] 1017264006779 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1017264006780 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1017264006781 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1017264006782 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1017264006783 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 1017264006784 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1017264006785 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1017264006786 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1017264006787 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1017264006788 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 1017264006789 putative active site [active] 1017264006790 catalytic site [active] 1017264006791 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 1017264006792 putative active site [active] 1017264006793 catalytic site [active] 1017264006794 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1017264006795 anti sigma factor interaction site; other site 1017264006796 regulatory phosphorylation site [posttranslational modification]; other site 1017264006797 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1017264006798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1017264006799 ATP binding site [chemical binding]; other site 1017264006800 Mg2+ binding site [ion binding]; other site 1017264006801 G-X-G motif; other site 1017264006802 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1017264006803 alanine racemase; Reviewed; Region: alr; PRK00053 1017264006804 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1017264006805 catalytic residue [active] 1017264006806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264006807 putative substrate translocation pore; other site 1017264006808 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1017264006809 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1017264006810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1017264006811 dimerization interface [polypeptide binding]; other site 1017264006812 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1017264006813 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1017264006814 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1017264006815 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1017264006816 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1017264006817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1017264006818 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 1017264006819 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1017264006820 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1017264006821 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1017264006822 Tir chaperone protein (CesT) family; Region: CesT; cl08444 1017264006823 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 1017264006824 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1017264006825 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 1017264006826 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 1017264006827 type III secretion system protein YscR; Provisional; Region: PRK12797 1017264006828 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1017264006829 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1017264006830 Type III secretion protein YscO; Region: YscO; pfam07321 1017264006831 type III secretion system ATPase; Provisional; Region: PRK06936 1017264006832 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1017264006833 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1017264006834 Walker A motif/ATP binding site; other site 1017264006835 Walker B motif; other site 1017264006836 type III secretion system protein; Reviewed; Region: PRK06937 1017264006837 Flagellar assembly protein FliH; Region: FliH; pfam02108 1017264006838 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 1017264006839 Type III secretion needle MxiH like; Region: MxiH; pfam09392 1017264006840 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1017264006841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1017264006842 binding surface 1017264006843 TPR motif; other site 1017264006844 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 1017264006845 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1017264006846 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869 1017264006847 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 1017264006848 type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511 1017264006849 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 1017264006850 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 1017264006851 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1017264006852 FHIPEP family; Region: FHIPEP; pfam00771 1017264006853 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1017264006854 Type III secretion needle MxiH like; Region: MxiH; pfam09392 1017264006855 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1017264006856 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006857 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006858 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006859 Integrase core domain; Region: rve; pfam00665 1017264006860 Integrase core domain; Region: rve_3; pfam13683 1017264006861 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1017264006862 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1017264006863 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1017264006864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1017264006865 dimerization interface [polypeptide binding]; other site 1017264006866 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1017264006867 dimer interface [polypeptide binding]; other site 1017264006868 putative CheW interface [polypeptide binding]; other site 1017264006869 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1017264006870 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1017264006871 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006872 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006873 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006874 Integrase core domain; Region: rve; pfam00665 1017264006875 Integrase core domain; Region: rve_3; pfam13683 1017264006876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1017264006877 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1017264006878 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1017264006879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1017264006880 motif II; other site 1017264006881 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1017264006882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264006883 putative PBP binding loops; other site 1017264006884 dimer interface [polypeptide binding]; other site 1017264006885 ABC-ATPase subunit interface; other site 1017264006886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264006887 dimer interface [polypeptide binding]; other site 1017264006888 conserved gate region; other site 1017264006889 putative PBP binding loops; other site 1017264006890 ABC-ATPase subunit interface; other site 1017264006891 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1017264006892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264006893 Walker A/P-loop; other site 1017264006894 ATP binding site [chemical binding]; other site 1017264006895 Q-loop/lid; other site 1017264006896 ABC transporter signature motif; other site 1017264006897 Walker B; other site 1017264006898 D-loop; other site 1017264006899 H-loop/switch region; other site 1017264006900 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1017264006901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264006902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1017264006903 dimerization interface [polypeptide binding]; other site 1017264006904 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 1017264006905 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1017264006906 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1017264006907 active site residue [active] 1017264006908 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1017264006909 active site residue [active] 1017264006910 heat shock protein HtpX; Provisional; Region: PRK05457 1017264006911 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1017264006912 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1017264006913 NADP binding site [chemical binding]; other site 1017264006914 dimer interface [polypeptide binding]; other site 1017264006915 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1017264006916 EamA-like transporter family; Region: EamA; pfam00892 1017264006917 EamA-like transporter family; Region: EamA; pfam00892 1017264006918 MarR family; Region: MarR_2; cl17246 1017264006919 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1017264006920 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1017264006921 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1017264006922 HlyD family secretion protein; Region: HlyD_3; pfam13437 1017264006923 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1017264006924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264006925 putative substrate translocation pore; other site 1017264006926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264006927 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1017264006928 tartrate dehydrogenase; Region: TTC; TIGR02089 1017264006929 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1017264006930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264006931 DNA-binding site [nucleotide binding]; DNA binding site 1017264006932 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264006933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264006934 homodimer interface [polypeptide binding]; other site 1017264006935 catalytic residue [active] 1017264006936 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1017264006937 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1017264006938 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1017264006939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264006940 dimer interface [polypeptide binding]; other site 1017264006941 conserved gate region; other site 1017264006942 putative PBP binding loops; other site 1017264006943 ABC-ATPase subunit interface; other site 1017264006944 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1017264006945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264006946 putative PBP binding loops; other site 1017264006947 dimer interface [polypeptide binding]; other site 1017264006948 ABC-ATPase subunit interface; other site 1017264006949 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1017264006950 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264006951 Walker A/P-loop; other site 1017264006952 ATP binding site [chemical binding]; other site 1017264006953 Q-loop/lid; other site 1017264006954 ABC transporter signature motif; other site 1017264006955 Walker B; other site 1017264006956 D-loop; other site 1017264006957 H-loop/switch region; other site 1017264006958 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1017264006959 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264006960 Walker A/P-loop; other site 1017264006961 ATP binding site [chemical binding]; other site 1017264006962 Q-loop/lid; other site 1017264006963 ABC transporter signature motif; other site 1017264006964 Walker B; other site 1017264006965 D-loop; other site 1017264006966 H-loop/switch region; other site 1017264006967 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1017264006968 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264006969 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264006970 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264006971 Integrase core domain; Region: rve; pfam00665 1017264006972 Integrase core domain; Region: rve_3; pfam13683 1017264006973 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1017264006974 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1017264006975 inhibitor-cofactor binding pocket; inhibition site 1017264006976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264006977 catalytic residue [active] 1017264006978 Cupin domain; Region: Cupin_2; pfam07883 1017264006979 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1017264006980 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1017264006981 active site 1017264006982 Zn binding site [ion binding]; other site 1017264006983 allantoate amidohydrolase; Reviewed; Region: PRK12893 1017264006984 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1017264006985 active site 1017264006986 metal binding site [ion binding]; metal-binding site 1017264006987 dimer interface [polypeptide binding]; other site 1017264006988 EamA-like transporter family; Region: EamA; pfam00892 1017264006989 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1017264006990 EamA-like transporter family; Region: EamA; pfam00892 1017264006991 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1017264006992 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1017264006993 NAD(P) binding site [chemical binding]; other site 1017264006994 catalytic residues [active] 1017264006995 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1017264006996 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1017264006997 putative ligand binding site [chemical binding]; other site 1017264006998 NAD binding site [chemical binding]; other site 1017264006999 dimerization interface [polypeptide binding]; other site 1017264007000 catalytic site [active] 1017264007001 aminotransferase; Provisional; Region: PRK06105 1017264007002 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1017264007003 inhibitor-cofactor binding pocket; inhibition site 1017264007004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264007005 catalytic residue [active] 1017264007006 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1017264007007 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1017264007008 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1017264007009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1017264007010 hypothetical protein; Validated; Region: PRK00110 1017264007011 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1017264007012 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1017264007013 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1017264007014 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1017264007015 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1017264007016 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1017264007017 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1017264007018 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1017264007019 active site 1017264007020 (T/H)XGH motif; other site 1017264007021 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1017264007022 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1017264007023 Maf-like protein; Region: Maf; pfam02545 1017264007024 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1017264007025 active site 1017264007026 dimer interface [polypeptide binding]; other site 1017264007027 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1017264007028 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1017264007029 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1017264007030 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264007031 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264007032 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264007033 Integrase core domain; Region: rve; pfam00665 1017264007034 Integrase core domain; Region: rve_3; pfam13683 1017264007035 ribonuclease G; Provisional; Region: PRK11712 1017264007036 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1017264007037 homodimer interface [polypeptide binding]; other site 1017264007038 oligonucleotide binding site [chemical binding]; other site 1017264007039 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1017264007040 Prephenate dehydratase; Region: PDT; pfam00800 1017264007041 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1017264007042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264007043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264007044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264007045 putative substrate translocation pore; other site 1017264007046 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1017264007047 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1017264007048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264007049 Walker A/P-loop; other site 1017264007050 ATP binding site [chemical binding]; other site 1017264007051 Q-loop/lid; other site 1017264007052 ABC transporter signature motif; other site 1017264007053 Walker B; other site 1017264007054 D-loop; other site 1017264007055 H-loop/switch region; other site 1017264007056 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1017264007057 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1017264007058 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1017264007059 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1017264007060 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1017264007061 putative active site [active] 1017264007062 Flagellin N-methylase; Region: FliB; pfam03692 1017264007063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1017264007064 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1017264007065 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1017264007066 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1017264007067 putative active site [active] 1017264007068 putative metal binding site [ion binding]; other site 1017264007069 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1017264007070 Sulfatase; Region: Sulfatase; cl17466 1017264007071 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1017264007072 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1017264007073 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1017264007074 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1017264007075 putative metal binding site; other site 1017264007076 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 1017264007077 putative active site [active] 1017264007078 putative metal binding site [ion binding]; other site 1017264007079 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1017264007080 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1017264007081 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1017264007082 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1017264007083 putative active site [active] 1017264007084 putative PHP Thumb interface [polypeptide binding]; other site 1017264007085 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1017264007086 generic binding surface I; other site 1017264007087 generic binding surface II; other site 1017264007088 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1017264007089 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1017264007090 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1017264007091 ATP binding site [chemical binding]; other site 1017264007092 putative Mg++ binding site [ion binding]; other site 1017264007093 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1017264007094 nucleotide binding region [chemical binding]; other site 1017264007095 ATP-binding site [chemical binding]; other site 1017264007096 Helicase associated domain (HA2); Region: HA2; pfam04408 1017264007097 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1017264007098 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1017264007099 N-acetylglutamate synthase; Validated; Region: PRK05279 1017264007100 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1017264007101 putative feedback inhibition sensing region; other site 1017264007102 putative nucleotide binding site [chemical binding]; other site 1017264007103 putative substrate binding site [chemical binding]; other site 1017264007104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1017264007105 Coenzyme A binding pocket [chemical binding]; other site 1017264007106 oxidative damage protection protein; Provisional; Region: PRK05408 1017264007107 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1017264007108 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1017264007109 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1017264007110 transcriptional regulator PhoU; Provisional; Region: PRK11115 1017264007111 PhoU domain; Region: PhoU; pfam01895 1017264007112 PhoU domain; Region: PhoU; pfam01895 1017264007113 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1017264007114 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1017264007115 active site 1017264007116 dimer interface [polypeptide binding]; other site 1017264007117 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1017264007118 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1017264007119 active site 1017264007120 RmuC family; Region: RmuC; pfam02646 1017264007121 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; pfam10707 1017264007122 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1017264007123 active site 1017264007124 DNA binding site [nucleotide binding] 1017264007125 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1017264007126 ArsC family; Region: ArsC; pfam03960 1017264007127 putative catalytic residues [active] 1017264007128 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1017264007129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264007130 dimer interface [polypeptide binding]; other site 1017264007131 conserved gate region; other site 1017264007132 putative PBP binding loops; other site 1017264007133 ABC-ATPase subunit interface; other site 1017264007134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264007135 dimer interface [polypeptide binding]; other site 1017264007136 conserved gate region; other site 1017264007137 putative PBP binding loops; other site 1017264007138 ABC-ATPase subunit interface; other site 1017264007139 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1017264007140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264007141 Walker A/P-loop; other site 1017264007142 ATP binding site [chemical binding]; other site 1017264007143 Q-loop/lid; other site 1017264007144 ABC transporter signature motif; other site 1017264007145 Walker B; other site 1017264007146 D-loop; other site 1017264007147 H-loop/switch region; other site 1017264007148 TOBE domain; Region: TOBE_2; pfam08402 1017264007149 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1017264007150 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1017264007151 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 1017264007152 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1017264007153 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1017264007154 apolar tunnel; other site 1017264007155 heme binding site [chemical binding]; other site 1017264007156 dimerization interface [polypeptide binding]; other site 1017264007157 FtsX-like permease family; Region: FtsX; pfam02687 1017264007158 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1017264007159 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1017264007160 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1017264007161 DctM-like transporters; Region: DctM; pfam06808 1017264007162 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1017264007163 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264007164 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264007165 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264007166 Integrase core domain; Region: rve; pfam00665 1017264007167 Integrase core domain; Region: rve_3; pfam13683 1017264007168 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1017264007169 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1017264007170 dimer interface [polypeptide binding]; other site 1017264007171 active site 1017264007172 citrylCoA binding site [chemical binding]; other site 1017264007173 NADH binding [chemical binding]; other site 1017264007174 cationic pore residues; other site 1017264007175 oxalacetate/citrate binding site [chemical binding]; other site 1017264007176 coenzyme A binding site [chemical binding]; other site 1017264007177 catalytic triad [active] 1017264007178 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 1017264007179 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1017264007180 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1017264007181 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 1017264007182 L-aspartate oxidase; Provisional; Region: PRK06175 1017264007183 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1017264007184 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1017264007185 SdhC subunit interface [polypeptide binding]; other site 1017264007186 proximal heme binding site [chemical binding]; other site 1017264007187 cardiolipin binding site; other site 1017264007188 Iron-sulfur protein interface; other site 1017264007189 proximal quinone binding site [chemical binding]; other site 1017264007190 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1017264007191 Iron-sulfur protein interface; other site 1017264007192 proximal quinone binding site [chemical binding]; other site 1017264007193 SdhD (CybS) interface [polypeptide binding]; other site 1017264007194 proximal heme binding site [chemical binding]; other site 1017264007195 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1017264007196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264007197 DNA-binding site [nucleotide binding]; DNA binding site 1017264007198 UTRA domain; Region: UTRA; pfam07702 1017264007199 malate dehydrogenase; Provisional; Region: PRK05442 1017264007200 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1017264007201 NAD(P) binding site [chemical binding]; other site 1017264007202 dimer interface [polypeptide binding]; other site 1017264007203 malate binding site [chemical binding]; other site 1017264007204 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1017264007205 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1017264007206 dimer interface [polypeptide binding]; other site 1017264007207 active site 1017264007208 citrylCoA binding site [chemical binding]; other site 1017264007209 oxalacetate/citrate binding site [chemical binding]; other site 1017264007210 coenzyme A binding site [chemical binding]; other site 1017264007211 catalytic triad [active] 1017264007212 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1017264007213 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1017264007214 substrate binding site [chemical binding]; other site 1017264007215 ligand binding site [chemical binding]; other site 1017264007216 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1017264007217 substrate binding site [chemical binding]; other site 1017264007218 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1017264007219 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1017264007220 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1017264007221 Predicted membrane protein [Function unknown]; Region: COG1981 1017264007222 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1017264007223 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1017264007224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264007225 S-adenosylmethionine binding site [chemical binding]; other site 1017264007226 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1017264007227 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1017264007228 putative active site [active] 1017264007229 putative metal binding site [ion binding]; other site 1017264007230 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1017264007231 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 1017264007232 active site 1017264007233 acyl-activating enzyme (AAE) consensus motif; other site 1017264007234 putative CoA binding site [chemical binding]; other site 1017264007235 AMP binding site [chemical binding]; other site 1017264007236 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1017264007237 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1017264007238 trimer interface [polypeptide binding]; other site 1017264007239 putative metal binding site [ion binding]; other site 1017264007240 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1017264007241 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1017264007242 dimerization interface [polypeptide binding]; other site 1017264007243 domain crossover interface; other site 1017264007244 redox-dependent activation switch; other site 1017264007245 Cupin domain; Region: Cupin_2; pfam07883 1017264007246 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1017264007247 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1017264007248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264007249 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1017264007250 NAD(P) binding site [chemical binding]; other site 1017264007251 active site 1017264007252 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1017264007253 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1017264007254 DNA binding site [nucleotide binding] 1017264007255 Predicted integral membrane protein [Function unknown]; Region: COG5616 1017264007256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1017264007257 TPR motif; other site 1017264007258 binding surface 1017264007259 TPR repeat; Region: TPR_11; pfam13414 1017264007260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1017264007261 TPR motif; other site 1017264007262 TPR repeat; Region: TPR_11; pfam13414 1017264007263 binding surface 1017264007264 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1017264007265 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1017264007266 enolase; Provisional; Region: eno; PRK00077 1017264007267 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1017264007268 dimer interface [polypeptide binding]; other site 1017264007269 metal binding site [ion binding]; metal-binding site 1017264007270 substrate binding pocket [chemical binding]; other site 1017264007271 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1017264007272 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1017264007273 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1017264007274 CTP synthetase; Validated; Region: pyrG; PRK05380 1017264007275 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1017264007276 Catalytic site [active] 1017264007277 active site 1017264007278 UTP binding site [chemical binding]; other site 1017264007279 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1017264007280 active site 1017264007281 putative oxyanion hole; other site 1017264007282 catalytic triad [active] 1017264007283 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264007284 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264007285 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264007286 Integrase core domain; Region: rve; pfam00665 1017264007287 Integrase core domain; Region: rve_3; pfam13683 1017264007288 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1017264007289 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1017264007290 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1017264007291 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1017264007292 active site 1017264007293 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1017264007294 homodimer interface [polypeptide binding]; other site 1017264007295 homotetramer interface [polypeptide binding]; other site 1017264007296 active site pocket [active] 1017264007297 cleavage site 1017264007298 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1017264007299 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1017264007300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264007301 dimer interface [polypeptide binding]; other site 1017264007302 conserved gate region; other site 1017264007303 putative PBP binding loops; other site 1017264007304 ABC-ATPase subunit interface; other site 1017264007305 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1017264007306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264007307 dimer interface [polypeptide binding]; other site 1017264007308 conserved gate region; other site 1017264007309 putative PBP binding loops; other site 1017264007310 ABC-ATPase subunit interface; other site 1017264007311 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1017264007312 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1017264007313 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1017264007314 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264007315 Walker A/P-loop; other site 1017264007316 ATP binding site [chemical binding]; other site 1017264007317 Q-loop/lid; other site 1017264007318 ABC transporter signature motif; other site 1017264007319 Walker B; other site 1017264007320 D-loop; other site 1017264007321 H-loop/switch region; other site 1017264007322 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1017264007323 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264007324 Walker A/P-loop; other site 1017264007325 ATP binding site [chemical binding]; other site 1017264007326 Q-loop/lid; other site 1017264007327 ABC transporter signature motif; other site 1017264007328 Walker B; other site 1017264007329 D-loop; other site 1017264007330 H-loop/switch region; other site 1017264007331 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1017264007332 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1017264007333 catalytic nucleophile [active] 1017264007334 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1017264007335 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1017264007336 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1017264007337 putative active site [active] 1017264007338 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1017264007339 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1017264007340 active site 1017264007341 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1017264007342 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1017264007343 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1017264007344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264007345 NAD(P) binding site [chemical binding]; other site 1017264007346 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1017264007347 active site 1017264007348 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1017264007349 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1017264007350 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1017264007351 tetramer interface [polypeptide binding]; other site 1017264007352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264007353 catalytic residue [active] 1017264007354 EamA-like transporter family; Region: EamA; pfam00892 1017264007355 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1017264007356 EamA-like transporter family; Region: EamA; pfam00892 1017264007357 acetyl-CoA synthetase; Provisional; Region: PRK00174 1017264007358 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1017264007359 active site 1017264007360 CoA binding site [chemical binding]; other site 1017264007361 acyl-activating enzyme (AAE) consensus motif; other site 1017264007362 AMP binding site [chemical binding]; other site 1017264007363 acetate binding site [chemical binding]; other site 1017264007364 Domain of unknown function (DUF336); Region: DUF336; cl01249 1017264007365 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1017264007366 NlpC/P60 family; Region: NLPC_P60; pfam00877 1017264007367 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 1017264007368 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264007369 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264007370 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264007371 Integrase core domain; Region: rve; pfam00665 1017264007372 Integrase core domain; Region: rve_3; pfam13683 1017264007373 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 1017264007374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264007375 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1017264007376 substrate binding site [chemical binding]; other site 1017264007377 dimerization interface [polypeptide binding]; other site 1017264007378 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1017264007379 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1017264007380 tetrameric interface [polypeptide binding]; other site 1017264007381 NAD binding site [chemical binding]; other site 1017264007382 catalytic residues [active] 1017264007383 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1017264007384 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1017264007385 putative ligand binding site [chemical binding]; other site 1017264007386 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264007387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264007388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264007389 dimerization interface [polypeptide binding]; other site 1017264007390 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1017264007391 Predicted permeases [General function prediction only]; Region: COG0795 1017264007392 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1017264007393 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1017264007394 interface (dimer of trimers) [polypeptide binding]; other site 1017264007395 Substrate-binding/catalytic site; other site 1017264007396 Zn-binding sites [ion binding]; other site 1017264007397 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 1017264007398 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1017264007399 YccA-like proteins; Region: YccA_like; cd10433 1017264007400 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264007401 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1017264007402 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1017264007403 active site 1017264007404 Zn binding site [ion binding]; other site 1017264007405 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1017264007406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264007407 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264007408 dimerization interface [polypeptide binding]; other site 1017264007409 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1017264007410 Recombination protein O N terminal; Region: RecO_N; pfam11967 1017264007411 Recombination protein O C terminal; Region: RecO_C; pfam02565 1017264007412 GTPase Era; Reviewed; Region: era; PRK00089 1017264007413 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1017264007414 G1 box; other site 1017264007415 GTP/Mg2+ binding site [chemical binding]; other site 1017264007416 Switch I region; other site 1017264007417 G2 box; other site 1017264007418 Switch II region; other site 1017264007419 G3 box; other site 1017264007420 G4 box; other site 1017264007421 G5 box; other site 1017264007422 KH domain; Region: KH_2; pfam07650 1017264007423 ribonuclease III; Reviewed; Region: rnc; PRK00102 1017264007424 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1017264007425 dimerization interface [polypeptide binding]; other site 1017264007426 active site 1017264007427 metal binding site [ion binding]; metal-binding site 1017264007428 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1017264007429 dsRNA binding site [nucleotide binding]; other site 1017264007430 signal peptidase I; Provisional; Region: PRK10861 1017264007431 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1017264007432 Catalytic site [active] 1017264007433 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1017264007434 GTP-binding protein LepA; Provisional; Region: PRK05433 1017264007435 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1017264007436 G1 box; other site 1017264007437 putative GEF interaction site [polypeptide binding]; other site 1017264007438 GTP/Mg2+ binding site [chemical binding]; other site 1017264007439 Switch I region; other site 1017264007440 G2 box; other site 1017264007441 G3 box; other site 1017264007442 Switch II region; other site 1017264007443 G4 box; other site 1017264007444 G5 box; other site 1017264007445 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1017264007446 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1017264007447 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1017264007448 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1017264007449 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1017264007450 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1017264007451 protein binding site [polypeptide binding]; other site 1017264007452 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1017264007453 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1017264007454 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1017264007455 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1017264007456 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1017264007457 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1017264007458 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1017264007459 DNA binding residues [nucleotide binding] 1017264007460 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1017264007461 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1017264007462 dimer interface [polypeptide binding]; other site 1017264007463 active site 1017264007464 acyl carrier protein; Provisional; Region: acpP; PRK00982 1017264007465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264007466 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1017264007467 NAD(P) binding site [chemical binding]; other site 1017264007468 active site 1017264007469 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1017264007470 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1017264007471 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1017264007472 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1017264007473 dimer interface [polypeptide binding]; other site 1017264007474 active site 1017264007475 CoA binding pocket [chemical binding]; other site 1017264007476 putative phosphate acyltransferase; Provisional; Region: PRK05331 1017264007477 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1017264007478 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1017264007479 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1017264007480 active site 1017264007481 dimer interface [polypeptide binding]; other site 1017264007482 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 1017264007483 putative SAM binding site [chemical binding]; other site 1017264007484 homodimer interface [polypeptide binding]; other site 1017264007485 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1017264007486 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1017264007487 amidase catalytic site [active] 1017264007488 Zn binding residues [ion binding]; other site 1017264007489 substrate binding site [chemical binding]; other site 1017264007490 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1017264007491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264007492 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1017264007493 putative substrate translocation pore; other site 1017264007494 hypothetical protein; Validated; Region: PRK02101 1017264007495 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264007496 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264007497 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264007498 Integrase core domain; Region: rve; pfam00665 1017264007499 Integrase core domain; Region: rve_3; pfam13683 1017264007500 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1017264007501 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1017264007502 NAD binding site [chemical binding]; other site 1017264007503 homotetramer interface [polypeptide binding]; other site 1017264007504 homodimer interface [polypeptide binding]; other site 1017264007505 substrate binding site [chemical binding]; other site 1017264007506 active site 1017264007507 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1017264007508 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1017264007509 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1017264007510 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1017264007511 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1017264007512 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1017264007513 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1017264007514 IucA / IucC family; Region: IucA_IucC; pfam04183 1017264007515 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1017264007516 siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950 1017264007517 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1017264007518 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1017264007519 [2Fe-2S] cluster binding site [ion binding]; other site 1017264007520 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1017264007521 alpha subunit interface [polypeptide binding]; other site 1017264007522 active site 1017264007523 substrate binding site [chemical binding]; other site 1017264007524 Fe binding site [ion binding]; other site 1017264007525 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1017264007526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1017264007527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264007528 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1017264007529 putative substrate translocation pore; other site 1017264007530 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1017264007531 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264007532 N-terminal plug; other site 1017264007533 ligand-binding site [chemical binding]; other site 1017264007534 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1017264007535 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1017264007536 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1017264007537 metal binding site [ion binding]; metal-binding site 1017264007538 active site 1017264007539 I-site; other site 1017264007540 seryl-tRNA synthetase; Provisional; Region: PRK05431 1017264007541 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1017264007542 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1017264007543 dimer interface [polypeptide binding]; other site 1017264007544 active site 1017264007545 motif 1; other site 1017264007546 motif 2; other site 1017264007547 motif 3; other site 1017264007548 recombination factor protein RarA; Reviewed; Region: PRK13342 1017264007549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264007550 Walker A motif; other site 1017264007551 ATP binding site [chemical binding]; other site 1017264007552 Walker B motif; other site 1017264007553 arginine finger; other site 1017264007554 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1017264007555 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1017264007556 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1017264007557 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1017264007558 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1017264007559 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1017264007560 thioredoxin reductase; Provisional; Region: PRK10262 1017264007561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1017264007562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1017264007563 Smr domain; Region: Smr; pfam01713 1017264007564 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1017264007565 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1017264007566 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 1017264007567 putative solute:sodium symporter small subunit; Region: Na_symport_sm; TIGR03647 1017264007568 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1017264007569 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1017264007570 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1017264007571 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1017264007572 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1017264007573 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1017264007574 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1017264007575 Ligand Binding Site [chemical binding]; other site 1017264007576 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1017264007577 GAF domain; Region: GAF_3; pfam13492 1017264007578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264007579 dimer interface [polypeptide binding]; other site 1017264007580 phosphorylation site [posttranslational modification] 1017264007581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264007582 Mg2+ binding site [ion binding]; other site 1017264007583 G-X-G motif; other site 1017264007584 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1017264007585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264007586 active site 1017264007587 phosphorylation site [posttranslational modification] 1017264007588 intermolecular recognition site; other site 1017264007589 dimerization interface [polypeptide binding]; other site 1017264007590 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1017264007591 DNA binding site [nucleotide binding] 1017264007592 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264007593 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264007594 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264007595 Integrase core domain; Region: rve; pfam00665 1017264007596 Integrase core domain; Region: rve_3; pfam13683 1017264007597 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1017264007598 O-Antigen ligase; Region: Wzy_C; pfam04932 1017264007599 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1017264007600 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1017264007601 isocitrate dehydrogenase; Validated; Region: PRK07362 1017264007602 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1017264007603 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1017264007604 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1017264007605 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1017264007606 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1017264007607 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264007608 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264007609 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264007610 Integrase core domain; Region: rve; pfam00665 1017264007611 Integrase core domain; Region: rve_3; pfam13683 1017264007612 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1017264007613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264007614 Walker A motif; other site 1017264007615 ATP binding site [chemical binding]; other site 1017264007616 Walker B motif; other site 1017264007617 arginine finger; other site 1017264007618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1017264007619 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1017264007620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1017264007621 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1017264007622 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1017264007623 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1017264007624 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1017264007625 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1017264007626 chaperone protein DnaJ; Provisional; Region: PRK10767 1017264007627 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1017264007628 HSP70 interaction site [polypeptide binding]; other site 1017264007629 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1017264007630 Zn binding sites [ion binding]; other site 1017264007631 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1017264007632 dimer interface [polypeptide binding]; other site 1017264007633 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1017264007634 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1017264007635 nucleotide binding site [chemical binding]; other site 1017264007636 NEF interaction site [polypeptide binding]; other site 1017264007637 SBD interface [polypeptide binding]; other site 1017264007638 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1017264007639 GrpE; Region: GrpE; pfam01025 1017264007640 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1017264007641 dimer interface [polypeptide binding]; other site 1017264007642 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1017264007643 ferrochelatase; Reviewed; Region: hemH; PRK00035 1017264007644 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1017264007645 C-terminal domain interface [polypeptide binding]; other site 1017264007646 active site 1017264007647 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1017264007648 active site 1017264007649 N-terminal domain interface [polypeptide binding]; other site 1017264007650 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1017264007651 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1017264007652 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 1017264007653 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1017264007654 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1017264007655 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1017264007656 Walker A/P-loop; other site 1017264007657 ATP binding site [chemical binding]; other site 1017264007658 Q-loop/lid; other site 1017264007659 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1017264007660 ABC transporter signature motif; other site 1017264007661 Walker B; other site 1017264007662 D-loop; other site 1017264007663 H-loop/switch region; other site 1017264007664 ferric uptake regulator; Provisional; Region: fur; PRK09462 1017264007665 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1017264007666 metal binding site 2 [ion binding]; metal-binding site 1017264007667 putative DNA binding helix; other site 1017264007668 metal binding site 1 [ion binding]; metal-binding site 1017264007669 dimer interface [polypeptide binding]; other site 1017264007670 structural Zn2+ binding site [ion binding]; other site 1017264007671 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1017264007672 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1017264007673 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1017264007674 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1017264007675 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1017264007676 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1017264007677 FAD binding domain; Region: FAD_binding_4; pfam01565 1017264007678 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1017264007679 pyrimidine utilization protein D; Region: RutD; TIGR03611 1017264007680 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1017264007681 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264007682 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1017264007683 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1017264007684 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1017264007685 putative active site [active] 1017264007686 putative substrate binding site [chemical binding]; other site 1017264007687 putative cosubstrate binding site; other site 1017264007688 catalytic site [active] 1017264007689 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1017264007690 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1017264007691 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1017264007692 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1017264007693 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 1017264007694 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1017264007695 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1017264007696 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1017264007697 active site 1017264007698 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1017264007699 dimer interface [polypeptide binding]; other site 1017264007700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264007701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264007702 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1017264007703 dimerization interface [polypeptide binding]; other site 1017264007704 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1017264007705 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 1017264007706 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1017264007707 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1017264007708 homodimer interface [polypeptide binding]; other site 1017264007709 NADP binding site [chemical binding]; other site 1017264007710 substrate binding site [chemical binding]; other site 1017264007711 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264007712 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264007713 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264007714 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264007715 Integrase core domain; Region: rve; pfam00665 1017264007716 Integrase core domain; Region: rve_3; pfam13683 1017264007717 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1017264007718 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1017264007719 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1017264007720 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1017264007721 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1017264007722 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1017264007723 Predicted small secreted protein [Function unknown]; Region: COG5510 1017264007724 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1017264007725 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1017264007726 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1017264007727 dimer interface [polypeptide binding]; other site 1017264007728 substrate binding site [chemical binding]; other site 1017264007729 metal binding sites [ion binding]; metal-binding site 1017264007730 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 1017264007731 HemY protein N-terminus; Region: HemY_N; pfam07219 1017264007732 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 1017264007733 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1017264007734 active site 1017264007735 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1017264007736 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1017264007737 domain interfaces; other site 1017264007738 active site 1017264007739 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1017264007740 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1017264007741 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1017264007742 CoA binding domain; Region: CoA_binding; smart00881 1017264007743 CoA-ligase; Region: Ligase_CoA; pfam00549 1017264007744 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1017264007745 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1017264007746 CoA-ligase; Region: Ligase_CoA; pfam00549 1017264007747 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 1017264007748 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1017264007749 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1017264007750 THF binding site; other site 1017264007751 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1017264007752 substrate binding site [chemical binding]; other site 1017264007753 THF binding site; other site 1017264007754 zinc-binding site [ion binding]; other site 1017264007755 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1017264007756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264007757 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1017264007758 putative dimerization interface [polypeptide binding]; other site 1017264007759 RecX family; Region: RecX; cl00936 1017264007760 recombinase A; Provisional; Region: recA; PRK09354 1017264007761 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1017264007762 hexamer interface [polypeptide binding]; other site 1017264007763 Walker A motif; other site 1017264007764 ATP binding site [chemical binding]; other site 1017264007765 Walker B motif; other site 1017264007766 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1017264007767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264007768 active site 1017264007769 phosphorylation site [posttranslational modification] 1017264007770 intermolecular recognition site; other site 1017264007771 dimerization interface [polypeptide binding]; other site 1017264007772 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1017264007773 DNA binding site [nucleotide binding] 1017264007774 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1017264007775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1017264007776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264007777 dimer interface [polypeptide binding]; other site 1017264007778 phosphorylation site [posttranslational modification] 1017264007779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264007780 ATP binding site [chemical binding]; other site 1017264007781 G-X-G motif; other site 1017264007782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264007783 putative substrate translocation pore; other site 1017264007784 enoyl-CoA hydratase; Provisional; Region: PRK06144 1017264007785 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264007786 substrate binding site [chemical binding]; other site 1017264007787 oxyanion hole (OAH) forming residues; other site 1017264007788 trimer interface [polypeptide binding]; other site 1017264007789 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1017264007790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264007791 Walker A/P-loop; other site 1017264007792 ATP binding site [chemical binding]; other site 1017264007793 Q-loop/lid; other site 1017264007794 ABC transporter signature motif; other site 1017264007795 Walker B; other site 1017264007796 D-loop; other site 1017264007797 H-loop/switch region; other site 1017264007798 TOBE domain; Region: TOBE_2; pfam08402 1017264007799 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1017264007800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264007801 dimer interface [polypeptide binding]; other site 1017264007802 conserved gate region; other site 1017264007803 putative PBP binding loops; other site 1017264007804 ABC-ATPase subunit interface; other site 1017264007805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264007806 dimer interface [polypeptide binding]; other site 1017264007807 conserved gate region; other site 1017264007808 putative PBP binding loops; other site 1017264007809 ABC-ATPase subunit interface; other site 1017264007810 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1017264007811 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1017264007812 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1017264007813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264007814 NAD(P) binding site [chemical binding]; other site 1017264007815 active site 1017264007816 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1017264007817 active site 2 [active] 1017264007818 active site 1 [active] 1017264007819 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1017264007820 DUF35 OB-fold domain; Region: DUF35; pfam01796 1017264007821 thiolase; Provisional; Region: PRK06158 1017264007822 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1017264007823 active site 1017264007824 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1017264007825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264007826 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264007827 dimerization interface [polypeptide binding]; other site 1017264007828 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264007829 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264007830 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1017264007831 aspartate carbamoyltransferase; Provisional; Region: PRK11891 1017264007832 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1017264007833 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1017264007834 Entericidin EcnA/B family; Region: Entericidin; cl02322 1017264007835 Endonuclease I; Region: Endonuclease_1; pfam04231 1017264007836 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 1017264007837 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 1017264007838 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1017264007839 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1017264007840 DNA binding residues [nucleotide binding] 1017264007841 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1017264007842 IHF - DNA interface [nucleotide binding]; other site 1017264007843 IHF dimer interface [polypeptide binding]; other site 1017264007844 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1017264007845 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1017264007846 putative tRNA-binding site [nucleotide binding]; other site 1017264007847 B3/4 domain; Region: B3_4; pfam03483 1017264007848 tRNA synthetase B5 domain; Region: B5; smart00874 1017264007849 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1017264007850 dimer interface [polypeptide binding]; other site 1017264007851 motif 1; other site 1017264007852 motif 3; other site 1017264007853 motif 2; other site 1017264007854 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1017264007855 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1017264007856 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1017264007857 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1017264007858 dimer interface [polypeptide binding]; other site 1017264007859 motif 1; other site 1017264007860 active site 1017264007861 motif 2; other site 1017264007862 motif 3; other site 1017264007863 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1017264007864 23S rRNA binding site [nucleotide binding]; other site 1017264007865 L21 binding site [polypeptide binding]; other site 1017264007866 L13 binding site [polypeptide binding]; other site 1017264007867 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1017264007868 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264007869 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264007870 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264007871 Integrase core domain; Region: rve; pfam00665 1017264007872 Integrase core domain; Region: rve_3; pfam13683 1017264007873 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1017264007874 trimer interface [polypeptide binding]; other site 1017264007875 active site 1017264007876 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264007877 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264007878 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264007879 Integrase core domain; Region: rve; pfam00665 1017264007880 Integrase core domain; Region: rve_3; pfam13683 1017264007881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264007882 DNA-binding site [nucleotide binding]; DNA binding site 1017264007883 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1017264007884 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264007885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264007886 homodimer interface [polypeptide binding]; other site 1017264007887 catalytic residue [active] 1017264007888 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264007889 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264007890 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264007891 Integrase core domain; Region: rve; pfam00665 1017264007892 Integrase core domain; Region: rve_3; pfam13683 1017264007893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264007894 S-adenosylmethionine binding site [chemical binding]; other site 1017264007895 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1017264007896 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1017264007897 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1017264007898 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264007899 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264007900 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264007901 Integrase core domain; Region: rve; pfam00665 1017264007902 Integrase core domain; Region: rve_3; pfam13683 1017264007903 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1017264007904 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1017264007905 DNA binding site [nucleotide binding] 1017264007906 domain linker motif; other site 1017264007907 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1017264007908 dimerization interface [polypeptide binding]; other site 1017264007909 ligand binding site [chemical binding]; other site 1017264007910 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1017264007911 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264007912 Walker A/P-loop; other site 1017264007913 ATP binding site [chemical binding]; other site 1017264007914 Q-loop/lid; other site 1017264007915 ABC transporter signature motif; other site 1017264007916 Walker B; other site 1017264007917 D-loop; other site 1017264007918 H-loop/switch region; other site 1017264007919 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1017264007920 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264007921 Walker A/P-loop; other site 1017264007922 ATP binding site [chemical binding]; other site 1017264007923 Q-loop/lid; other site 1017264007924 ABC transporter signature motif; other site 1017264007925 Walker B; other site 1017264007926 D-loop; other site 1017264007927 H-loop/switch region; other site 1017264007928 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1017264007929 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1017264007930 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1017264007931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264007932 dimer interface [polypeptide binding]; other site 1017264007933 conserved gate region; other site 1017264007934 putative PBP binding loops; other site 1017264007935 ABC-ATPase subunit interface; other site 1017264007936 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1017264007937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264007938 dimer interface [polypeptide binding]; other site 1017264007939 conserved gate region; other site 1017264007940 putative PBP binding loops; other site 1017264007941 ABC-ATPase subunit interface; other site 1017264007942 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1017264007943 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1017264007944 Uncharacterized conserved protein [Function unknown]; Region: COG5649 1017264007945 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1017264007946 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1017264007947 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1017264007948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264007949 DNA-binding site [nucleotide binding]; DNA binding site 1017264007950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264007951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264007952 homodimer interface [polypeptide binding]; other site 1017264007953 catalytic residue [active] 1017264007954 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1017264007955 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 1017264007956 putative NAD(P) binding site [chemical binding]; other site 1017264007957 putative substrate binding site [chemical binding]; other site 1017264007958 catalytic Zn binding site [ion binding]; other site 1017264007959 structural Zn binding site [ion binding]; other site 1017264007960 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1017264007961 Transcriptional activator [Transcription]; Region: ChrR; COG3806 1017264007962 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1017264007963 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1017264007964 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1017264007965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264007966 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1017264007967 dimerization interface [polypeptide binding]; other site 1017264007968 substrate binding pocket [chemical binding]; other site 1017264007969 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1017264007970 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1017264007971 conserved cys residue [active] 1017264007972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1017264007973 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1017264007974 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1017264007975 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1017264007976 Predicted membrane protein [Function unknown]; Region: COG1289 1017264007977 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1017264007978 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1017264007979 Beta-Casp domain; Region: Beta-Casp; smart01027 1017264007980 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1017264007981 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1017264007982 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1017264007983 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1017264007984 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1017264007985 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 1017264007986 substrate binding site [chemical binding]; other site 1017264007987 Protein of unknown function (DUF521); Region: DUF521; pfam04412 1017264007988 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 1017264007989 substrate binding site [chemical binding]; other site 1017264007990 ligand binding site [chemical binding]; other site 1017264007991 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264007992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264007993 dimer interface [polypeptide binding]; other site 1017264007994 conserved gate region; other site 1017264007995 putative PBP binding loops; other site 1017264007996 ABC-ATPase subunit interface; other site 1017264007997 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1017264007998 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1017264007999 Walker A/P-loop; other site 1017264008000 ATP binding site [chemical binding]; other site 1017264008001 Q-loop/lid; other site 1017264008002 ABC transporter signature motif; other site 1017264008003 Walker B; other site 1017264008004 D-loop; other site 1017264008005 H-loop/switch region; other site 1017264008006 NMT1-like family; Region: NMT1_2; pfam13379 1017264008007 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1017264008008 substrate binding pocket [chemical binding]; other site 1017264008009 membrane-bound complex binding site; other site 1017264008010 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1017264008011 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1017264008012 active site 1017264008013 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1017264008014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264008015 putative substrate translocation pore; other site 1017264008016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264008017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264008018 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1017264008019 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1017264008020 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1017264008021 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1017264008022 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1017264008023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1017264008024 non-specific DNA binding site [nucleotide binding]; other site 1017264008025 salt bridge; other site 1017264008026 sequence-specific DNA binding site [nucleotide binding]; other site 1017264008027 GMP synthase; Reviewed; Region: guaA; PRK00074 1017264008028 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1017264008029 AMP/PPi binding site [chemical binding]; other site 1017264008030 candidate oxyanion hole; other site 1017264008031 catalytic triad [active] 1017264008032 potential glutamine specificity residues [chemical binding]; other site 1017264008033 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1017264008034 ATP Binding subdomain [chemical binding]; other site 1017264008035 Ligand Binding sites [chemical binding]; other site 1017264008036 Dimerization subdomain; other site 1017264008037 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1017264008038 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1017264008039 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1017264008040 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1017264008041 active site 1017264008042 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; cl01461 1017264008043 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008044 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008045 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008046 Integrase core domain; Region: rve; pfam00665 1017264008047 Integrase core domain; Region: rve_3; pfam13683 1017264008048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264008049 AAA domain; Region: AAA_23; pfam13476 1017264008050 Walker A/P-loop; other site 1017264008051 ATP binding site [chemical binding]; other site 1017264008052 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1017264008053 active site 1017264008054 metal binding site [ion binding]; metal-binding site 1017264008055 DNA binding site [nucleotide binding] 1017264008056 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1017264008057 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264008058 putative DNA binding site [nucleotide binding]; other site 1017264008059 putative Zn2+ binding site [ion binding]; other site 1017264008060 AsnC family; Region: AsnC_trans_reg; pfam01037 1017264008061 Protein of unknown function (DUF502); Region: DUF502; pfam04367 1017264008062 transglutaminase; Provisional; Region: tgl; PRK03187 1017264008063 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1017264008064 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 1017264008065 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1017264008066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264008067 dimer interface [polypeptide binding]; other site 1017264008068 conserved gate region; other site 1017264008069 putative PBP binding loops; other site 1017264008070 ABC-ATPase subunit interface; other site 1017264008071 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1017264008072 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1017264008073 Walker A/P-loop; other site 1017264008074 ATP binding site [chemical binding]; other site 1017264008075 Q-loop/lid; other site 1017264008076 ABC transporter signature motif; other site 1017264008077 Walker B; other site 1017264008078 D-loop; other site 1017264008079 H-loop/switch region; other site 1017264008080 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1017264008081 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1017264008082 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1017264008083 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1017264008084 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264008085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264008086 putative DNA binding site [nucleotide binding]; other site 1017264008087 putative Zn2+ binding site [ion binding]; other site 1017264008088 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264008089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1017264008090 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1017264008091 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1017264008092 L-aspartate oxidase; Provisional; Region: PRK06175 1017264008093 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1017264008094 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1017264008095 NRDE protein; Region: NRDE; cl01315 1017264008096 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1017264008097 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264008098 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1017264008099 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1017264008100 inhibitor site; inhibition site 1017264008101 active site 1017264008102 dimer interface [polypeptide binding]; other site 1017264008103 catalytic residue [active] 1017264008104 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264008105 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1017264008106 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264008107 MAPEG family; Region: MAPEG; cl09190 1017264008108 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1017264008109 hypothetical protein; Provisional; Region: PRK09256 1017264008110 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1017264008111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1017264008112 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1017264008113 active site 1017264008114 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1017264008115 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1017264008116 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1017264008117 intersubunit interface [polypeptide binding]; other site 1017264008118 active site 1017264008119 Zn2+ binding site [ion binding]; other site 1017264008120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1017264008121 non-specific DNA binding site [nucleotide binding]; other site 1017264008122 salt bridge; other site 1017264008123 sequence-specific DNA binding site [nucleotide binding]; other site 1017264008124 Cupin domain; Region: Cupin_2; pfam07883 1017264008125 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1017264008126 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1017264008127 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008128 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008129 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008130 Integrase core domain; Region: rve; pfam00665 1017264008131 Integrase core domain; Region: rve_3; pfam13683 1017264008132 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1017264008133 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1017264008134 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1017264008135 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1017264008136 dimerization interface [polypeptide binding]; other site 1017264008137 ATP binding site [chemical binding]; other site 1017264008138 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1017264008139 dimerization interface [polypeptide binding]; other site 1017264008140 ATP binding site [chemical binding]; other site 1017264008141 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1017264008142 putative active site [active] 1017264008143 catalytic triad [active] 1017264008144 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1017264008145 DctM-like transporters; Region: DctM; pfam06808 1017264008146 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1017264008147 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1017264008148 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1017264008149 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008150 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008151 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008152 Integrase core domain; Region: rve; pfam00665 1017264008153 Integrase core domain; Region: rve_3; pfam13683 1017264008154 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1017264008155 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1017264008156 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1017264008157 active site 1017264008158 AMP binding site [chemical binding]; other site 1017264008159 homodimer interface [polypeptide binding]; other site 1017264008160 acyl-activating enzyme (AAE) consensus motif; other site 1017264008161 CoA binding site [chemical binding]; other site 1017264008162 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1017264008163 CoenzymeA binding site [chemical binding]; other site 1017264008164 subunit interaction site [polypeptide binding]; other site 1017264008165 PHB binding site; other site 1017264008166 enoyl-CoA hydratase; Provisional; Region: PRK08140 1017264008167 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264008168 substrate binding site [chemical binding]; other site 1017264008169 oxyanion hole (OAH) forming residues; other site 1017264008170 trimer interface [polypeptide binding]; other site 1017264008171 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1017264008172 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 1017264008173 Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Region: ALDH_PAD-PaaZ; cd07127 1017264008174 NADP binding site [chemical binding]; other site 1017264008175 catalytic residues [active] 1017264008176 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008177 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008178 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008179 Integrase core domain; Region: rve; pfam00665 1017264008180 Integrase core domain; Region: rve_3; pfam13683 1017264008181 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1017264008182 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1017264008183 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1017264008184 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1017264008185 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1017264008186 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1017264008187 PaaX-like protein; Region: PaaX; pfam07848 1017264008188 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1017264008189 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1017264008190 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1017264008191 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1017264008192 catalytic site [active] 1017264008193 putative active site [active] 1017264008194 putative substrate binding site [chemical binding]; other site 1017264008195 dimer interface [polypeptide binding]; other site 1017264008196 Peptidase family M48; Region: Peptidase_M48; pfam01435 1017264008197 GTPase RsgA; Reviewed; Region: PRK00098 1017264008198 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1017264008199 RNA binding site [nucleotide binding]; other site 1017264008200 homodimer interface [polypeptide binding]; other site 1017264008201 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1017264008202 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1017264008203 GTP/Mg2+ binding site [chemical binding]; other site 1017264008204 G4 box; other site 1017264008205 G5 box; other site 1017264008206 G1 box; other site 1017264008207 Switch I region; other site 1017264008208 G2 box; other site 1017264008209 G3 box; other site 1017264008210 Switch II region; other site 1017264008211 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1017264008212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264008213 dimer interface [polypeptide binding]; other site 1017264008214 conserved gate region; other site 1017264008215 putative PBP binding loops; other site 1017264008216 ABC-ATPase subunit interface; other site 1017264008217 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1017264008218 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 1017264008219 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1017264008220 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1017264008221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264008222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264008223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264008224 dimerization interface [polypeptide binding]; other site 1017264008225 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 1017264008226 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1017264008227 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1017264008228 NAD synthetase; Provisional; Region: PRK13981 1017264008229 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1017264008230 multimer interface [polypeptide binding]; other site 1017264008231 active site 1017264008232 catalytic triad [active] 1017264008233 protein interface 1 [polypeptide binding]; other site 1017264008234 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1017264008235 homodimer interface [polypeptide binding]; other site 1017264008236 NAD binding pocket [chemical binding]; other site 1017264008237 ATP binding pocket [chemical binding]; other site 1017264008238 Mg binding site [ion binding]; other site 1017264008239 active-site loop [active] 1017264008240 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1017264008241 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 1017264008242 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1017264008243 argininosuccinate lyase; Provisional; Region: PRK00855 1017264008244 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1017264008245 active sites [active] 1017264008246 tetramer interface [polypeptide binding]; other site 1017264008247 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1017264008248 putative FMN binding site [chemical binding]; other site 1017264008249 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008250 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008251 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008252 Integrase core domain; Region: rve; pfam00665 1017264008253 Integrase core domain; Region: rve_3; pfam13683 1017264008254 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1017264008255 PBP superfamily domain; Region: PBP_like; pfam12727 1017264008256 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1017264008257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1017264008258 FeS/SAM binding site; other site 1017264008259 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1017264008260 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1017264008261 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1017264008262 dimer interface [polypeptide binding]; other site 1017264008263 putative functional site; other site 1017264008264 putative MPT binding site; other site 1017264008265 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1017264008266 MPT binding site; other site 1017264008267 trimer interface [polypeptide binding]; other site 1017264008268 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1017264008269 MoaE homodimer interface [polypeptide binding]; other site 1017264008270 MoaD interaction [polypeptide binding]; other site 1017264008271 active site residues [active] 1017264008272 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1017264008273 MoaE interaction surface [polypeptide binding]; other site 1017264008274 MoeB interaction surface [polypeptide binding]; other site 1017264008275 thiocarboxylated glycine; other site 1017264008276 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1017264008277 trimer interface [polypeptide binding]; other site 1017264008278 dimer interface [polypeptide binding]; other site 1017264008279 putative active site [active] 1017264008280 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1017264008281 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1017264008282 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1017264008283 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1017264008284 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1017264008285 ligand binding site [chemical binding]; other site 1017264008286 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1017264008287 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1017264008288 catalytic triad [active] 1017264008289 dimer interface [polypeptide binding]; other site 1017264008290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264008291 putative MFS family transporter protein; Provisional; Region: PRK03633 1017264008292 putative substrate translocation pore; other site 1017264008293 biotin synthase; Region: bioB; TIGR00433 1017264008294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1017264008295 FeS/SAM binding site; other site 1017264008296 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1017264008297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264008298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264008299 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264008300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264008301 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264008302 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1017264008303 Heavy-metal-associated domain; Region: HMA; pfam00403 1017264008304 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1017264008305 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1017264008306 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1017264008307 DNA binding residues [nucleotide binding] 1017264008308 dimer interface [polypeptide binding]; other site 1017264008309 putative metal binding site [ion binding]; other site 1017264008310 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008311 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008312 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008313 Integrase core domain; Region: rve; pfam00665 1017264008314 Integrase core domain; Region: rve_3; pfam13683 1017264008315 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1017264008316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264008317 NAD(P) binding site [chemical binding]; other site 1017264008318 active site 1017264008319 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1017264008320 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1017264008321 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1017264008322 Subunit I/III interface [polypeptide binding]; other site 1017264008323 Subunit III/IV interface [polypeptide binding]; other site 1017264008324 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1017264008325 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1017264008326 D-pathway; other site 1017264008327 Putative ubiquinol binding site [chemical binding]; other site 1017264008328 Low-spin heme (heme b) binding site [chemical binding]; other site 1017264008329 Putative water exit pathway; other site 1017264008330 Binuclear center (heme o3/CuB) [ion binding]; other site 1017264008331 K-pathway; other site 1017264008332 Putative proton exit pathway; other site 1017264008333 metabolite-proton symporter; Region: 2A0106; TIGR00883 1017264008334 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008335 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008336 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008337 Integrase core domain; Region: rve; pfam00665 1017264008338 Integrase core domain; Region: rve_3; pfam13683 1017264008339 Membrane fusogenic activity; Region: BMFP; pfam04380 1017264008340 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1017264008341 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1017264008342 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1017264008343 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1017264008344 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1017264008345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264008346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264008347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264008348 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1017264008349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264008350 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1017264008351 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1017264008352 Walker A/P-loop; other site 1017264008353 ATP binding site [chemical binding]; other site 1017264008354 Q-loop/lid; other site 1017264008355 ABC transporter signature motif; other site 1017264008356 Walker B; other site 1017264008357 D-loop; other site 1017264008358 H-loop/switch region; other site 1017264008359 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1017264008360 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264008361 Walker A/P-loop; other site 1017264008362 ATP binding site [chemical binding]; other site 1017264008363 Q-loop/lid; other site 1017264008364 ABC transporter signature motif; other site 1017264008365 Walker B; other site 1017264008366 D-loop; other site 1017264008367 H-loop/switch region; other site 1017264008368 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1017264008369 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1017264008370 TM-ABC transporter signature motif; other site 1017264008371 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1017264008372 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264008373 TM-ABC transporter signature motif; other site 1017264008374 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1017264008375 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1017264008376 dimerization interface [polypeptide binding]; other site 1017264008377 ligand binding site [chemical binding]; other site 1017264008378 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008379 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008380 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008381 Integrase core domain; Region: rve; pfam00665 1017264008382 Integrase core domain; Region: rve_3; pfam13683 1017264008383 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 1017264008384 Proline dehydrogenase; Region: Pro_dh; pfam01619 1017264008385 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1017264008386 Glutamate binding site [chemical binding]; other site 1017264008387 NAD binding site [chemical binding]; other site 1017264008388 catalytic residues [active] 1017264008389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1017264008390 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1017264008391 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1017264008392 mce related protein; Region: MCE; pfam02470 1017264008393 mce related protein; Region: MCE; pfam02470 1017264008394 mce related protein; Region: MCE; pfam02470 1017264008395 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1017264008396 Paraquat-inducible protein A; Region: PqiA; pfam04403 1017264008397 Paraquat-inducible protein A; Region: PqiA; pfam04403 1017264008398 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1017264008399 Clp amino terminal domain; Region: Clp_N; pfam02861 1017264008400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264008401 Walker A motif; other site 1017264008402 ATP binding site [chemical binding]; other site 1017264008403 Walker B motif; other site 1017264008404 arginine finger; other site 1017264008405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264008406 Walker A motif; other site 1017264008407 ATP binding site [chemical binding]; other site 1017264008408 Walker B motif; other site 1017264008409 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1017264008410 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 1017264008411 Transglycosylase; Region: Transgly; pfam00912 1017264008412 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1017264008413 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1017264008414 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1017264008415 MG2 domain; Region: A2M_N; pfam01835 1017264008416 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1017264008417 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1017264008418 surface patch; other site 1017264008419 thioester region; other site 1017264008420 specificity defining residues; other site 1017264008421 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1017264008422 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1017264008423 DNA-binding site [nucleotide binding]; DNA binding site 1017264008424 RNA-binding motif; other site 1017264008425 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1017264008426 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1017264008427 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1017264008428 dimer interface [polypeptide binding]; other site 1017264008429 active site 1017264008430 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 1017264008431 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1017264008432 putative ion selectivity filter; other site 1017264008433 putative pore gating glutamate residue; other site 1017264008434 putative H+/Cl- coupling transport residue; other site 1017264008435 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1017264008436 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1017264008437 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1017264008438 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1017264008439 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1017264008440 generic binding surface II; other site 1017264008441 generic binding surface I; other site 1017264008442 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008443 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008444 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008445 Integrase core domain; Region: rve; pfam00665 1017264008446 Integrase core domain; Region: rve_3; pfam13683 1017264008447 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1017264008448 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1017264008449 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1017264008450 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1017264008451 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1017264008452 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1017264008453 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1017264008454 Ligand binding site; other site 1017264008455 oligomer interface; other site 1017264008456 adenylate kinase; Reviewed; Region: adk; PRK00279 1017264008457 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1017264008458 AMP-binding site [chemical binding]; other site 1017264008459 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1017264008460 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1017264008461 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1017264008462 NAD binding site [chemical binding]; other site 1017264008463 homodimer interface [polypeptide binding]; other site 1017264008464 homotetramer interface [polypeptide binding]; other site 1017264008465 active site 1017264008466 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1017264008467 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1017264008468 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1017264008469 FecR protein; Region: FecR; pfam04773 1017264008470 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1017264008471 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1017264008472 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008473 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008474 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008475 Integrase core domain; Region: rve; pfam00665 1017264008476 Integrase core domain; Region: rve_3; pfam13683 1017264008477 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1017264008478 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1017264008479 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1017264008480 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1017264008481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264008482 catalytic residue [active] 1017264008483 homoserine dehydrogenase; Provisional; Region: PRK06349 1017264008484 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1017264008485 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1017264008486 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1017264008487 aminotransferase; Validated; Region: PRK08175 1017264008488 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264008489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264008490 homodimer interface [polypeptide binding]; other site 1017264008491 catalytic residue [active] 1017264008492 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 1017264008493 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1017264008494 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1017264008495 catalytic triad [active] 1017264008496 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1017264008497 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1017264008498 putative active site [active] 1017264008499 PhoH-like protein; Region: PhoH; pfam02562 1017264008500 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1017264008501 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1017264008502 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1017264008503 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1017264008504 replicative DNA helicase; Provisional; Region: PRK07004 1017264008505 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1017264008506 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1017264008507 Walker A motif; other site 1017264008508 ATP binding site [chemical binding]; other site 1017264008509 Walker B motif; other site 1017264008510 DNA binding loops [nucleotide binding] 1017264008511 serine/threonine protein kinase; Provisional; Region: PRK14879 1017264008512 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1017264008513 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1017264008514 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1017264008515 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1017264008516 primosomal replication protein N; Reviewed; Region: PRK00036 1017264008517 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1017264008518 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1017264008519 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1017264008520 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1017264008521 TPP-binding site; other site 1017264008522 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1017264008523 PYR/PP interface [polypeptide binding]; other site 1017264008524 dimer interface [polypeptide binding]; other site 1017264008525 TPP binding site [chemical binding]; other site 1017264008526 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1017264008527 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1017264008528 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1017264008529 substrate binding pocket [chemical binding]; other site 1017264008530 chain length determination region; other site 1017264008531 substrate-Mg2+ binding site; other site 1017264008532 catalytic residues [active] 1017264008533 aspartate-rich region 1; other site 1017264008534 active site lid residues [active] 1017264008535 aspartate-rich region 2; other site 1017264008536 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1017264008537 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1017264008538 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264008539 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264008540 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264008541 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1017264008542 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1017264008543 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1017264008544 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1017264008545 [2Fe-2S] cluster binding site [ion binding]; other site 1017264008546 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1017264008547 alpha subunit interface [polypeptide binding]; other site 1017264008548 active site 1017264008549 substrate binding site [chemical binding]; other site 1017264008550 Fe binding site [ion binding]; other site 1017264008551 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1017264008552 MgtE intracellular N domain; Region: MgtE_N; smart00924 1017264008553 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1017264008554 Divalent cation transporter; Region: MgtE; pfam01769 1017264008555 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1017264008556 Predicted membrane protein [Function unknown]; Region: COG2855 1017264008557 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264008558 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264008559 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1017264008560 putative dimerization interface [polypeptide binding]; other site 1017264008561 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1017264008562 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1017264008563 metal binding site [ion binding]; metal-binding site 1017264008564 putative dimer interface [polypeptide binding]; other site 1017264008565 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1017264008566 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1017264008567 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1017264008568 acyl-activating enzyme (AAE) consensus motif; other site 1017264008569 putative AMP binding site [chemical binding]; other site 1017264008570 putative active site [active] 1017264008571 putative CoA binding site [chemical binding]; other site 1017264008572 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008573 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008574 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008575 Integrase core domain; Region: rve; pfam00665 1017264008576 Integrase core domain; Region: rve_3; pfam13683 1017264008577 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1017264008578 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1017264008579 active site 1017264008580 dimerization interface [polypeptide binding]; other site 1017264008581 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1017264008582 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1017264008583 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 1017264008584 active site 1017264008585 catalytic site [active] 1017264008586 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1017264008587 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1017264008588 Walker A/P-loop; other site 1017264008589 ATP binding site [chemical binding]; other site 1017264008590 Q-loop/lid; other site 1017264008591 ABC transporter signature motif; other site 1017264008592 Walker B; other site 1017264008593 D-loop; other site 1017264008594 H-loop/switch region; other site 1017264008595 NIL domain; Region: NIL; pfam09383 1017264008596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264008597 ABC-ATPase subunit interface; other site 1017264008598 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1017264008599 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1017264008600 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008601 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008602 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008603 Integrase core domain; Region: rve; pfam00665 1017264008604 Integrase core domain; Region: rve_3; pfam13683 1017264008605 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1017264008606 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1017264008607 putative active site [active] 1017264008608 metal binding site [ion binding]; metal-binding site 1017264008609 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008610 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008611 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008612 Integrase core domain; Region: rve; pfam00665 1017264008613 Integrase core domain; Region: rve_3; pfam13683 1017264008614 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 1017264008615 substrate binding site [chemical binding]; other site 1017264008616 Protein of unknown function (DUF521); Region: DUF521; pfam04412 1017264008617 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 1017264008618 substrate binding site [chemical binding]; other site 1017264008619 ligand binding site [chemical binding]; other site 1017264008620 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1017264008621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264008622 DNA-binding site [nucleotide binding]; DNA binding site 1017264008623 FCD domain; Region: FCD; pfam07729 1017264008624 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264008625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264008626 dimer interface [polypeptide binding]; other site 1017264008627 conserved gate region; other site 1017264008628 putative PBP binding loops; other site 1017264008629 ABC-ATPase subunit interface; other site 1017264008630 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1017264008631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264008632 dimer interface [polypeptide binding]; other site 1017264008633 conserved gate region; other site 1017264008634 putative PBP binding loops; other site 1017264008635 ABC-ATPase subunit interface; other site 1017264008636 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1017264008637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264008638 Walker A/P-loop; other site 1017264008639 ATP binding site [chemical binding]; other site 1017264008640 Q-loop/lid; other site 1017264008641 ABC transporter signature motif; other site 1017264008642 Walker B; other site 1017264008643 D-loop; other site 1017264008644 H-loop/switch region; other site 1017264008645 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1017264008646 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1017264008647 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1017264008648 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264008649 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1017264008650 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1017264008651 DNA binding residues [nucleotide binding] 1017264008652 dimer interface [polypeptide binding]; other site 1017264008653 [2Fe-2S] cluster binding site [ion binding]; other site 1017264008654 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1017264008655 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1017264008656 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1017264008657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264008658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264008659 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1017264008660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264008661 NAD(P) binding site [chemical binding]; other site 1017264008662 active site 1017264008663 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008664 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008665 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008666 Integrase core domain; Region: rve; pfam00665 1017264008667 Integrase core domain; Region: rve_3; pfam13683 1017264008668 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008669 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008670 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008671 Integrase core domain; Region: rve; pfam00665 1017264008672 Integrase core domain; Region: rve_3; pfam13683 1017264008673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264008674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264008675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1017264008676 dimerization interface [polypeptide binding]; other site 1017264008677 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1017264008678 active site 1017264008679 oligomerization interface [polypeptide binding]; other site 1017264008680 metal binding site [ion binding]; metal-binding site 1017264008681 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1017264008682 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1017264008683 trimer interface [polypeptide binding]; other site 1017264008684 eyelet of channel; other site 1017264008685 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008686 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008687 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008688 Integrase core domain; Region: rve; pfam00665 1017264008689 Integrase core domain; Region: rve_3; pfam13683 1017264008690 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1017264008691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264008692 NAD(P) binding site [chemical binding]; other site 1017264008693 active site 1017264008694 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1017264008695 classical (c) SDRs; Region: SDR_c; cd05233 1017264008696 NAD(P) binding site [chemical binding]; other site 1017264008697 active site 1017264008698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264008699 metabolite-proton symporter; Region: 2A0106; TIGR00883 1017264008700 putative substrate translocation pore; other site 1017264008701 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1017264008702 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1017264008703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264008704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264008705 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1017264008706 dimerization interface [polypeptide binding]; other site 1017264008707 substrate binding pocket [chemical binding]; other site 1017264008708 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1017264008709 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264008710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264008711 homodimer interface [polypeptide binding]; other site 1017264008712 catalytic residue [active] 1017264008713 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1017264008714 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1017264008715 Zn2+ binding site [ion binding]; other site 1017264008716 Mg2+ binding site [ion binding]; other site 1017264008717 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1017264008718 metal-binding site [ion binding] 1017264008719 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1017264008720 metal-binding site [ion binding] 1017264008721 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1017264008722 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1017264008723 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1017264008724 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008725 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008726 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008727 Integrase core domain; Region: rve; pfam00665 1017264008728 Integrase core domain; Region: rve_3; pfam13683 1017264008729 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1017264008730 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1017264008731 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1017264008732 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1017264008733 NAD(P) binding site [chemical binding]; other site 1017264008734 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1017264008735 CoenzymeA binding site [chemical binding]; other site 1017264008736 subunit interaction site [polypeptide binding]; other site 1017264008737 PHB binding site; other site 1017264008738 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1017264008739 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1017264008740 Walker A/P-loop; other site 1017264008741 ATP binding site [chemical binding]; other site 1017264008742 Q-loop/lid; other site 1017264008743 ABC transporter signature motif; other site 1017264008744 Walker B; other site 1017264008745 D-loop; other site 1017264008746 H-loop/switch region; other site 1017264008747 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264008748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264008749 dimer interface [polypeptide binding]; other site 1017264008750 conserved gate region; other site 1017264008751 putative PBP binding loops; other site 1017264008752 ABC-ATPase subunit interface; other site 1017264008753 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 1017264008754 putative active site [active] 1017264008755 Zn binding site [ion binding]; other site 1017264008756 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1017264008757 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1017264008758 acyl-activating enzyme (AAE) consensus motif; other site 1017264008759 AMP binding site [chemical binding]; other site 1017264008760 active site 1017264008761 CoA binding site [chemical binding]; other site 1017264008762 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1017264008763 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1017264008764 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264008765 putative DNA binding site [nucleotide binding]; other site 1017264008766 putative Zn2+ binding site [ion binding]; other site 1017264008767 AsnC family; Region: AsnC_trans_reg; pfam01037 1017264008768 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264008769 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1017264008770 Lumazine binding domain; Region: Lum_binding; pfam00677 1017264008771 Lumazine binding domain; Region: Lum_binding; pfam00677 1017264008772 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1017264008773 Amidase; Region: Amidase; cl11426 1017264008774 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1017264008775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264008776 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1017264008777 dimerization interface [polypeptide binding]; other site 1017264008778 substrate binding pocket [chemical binding]; other site 1017264008779 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1017264008780 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1017264008781 nucleoside/Zn binding site; other site 1017264008782 dimer interface [polypeptide binding]; other site 1017264008783 catalytic motif [active] 1017264008784 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1017264008785 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1017264008786 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1017264008787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264008788 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264008789 dimerization interface [polypeptide binding]; other site 1017264008790 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1017264008791 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1017264008792 active site 1017264008793 FMN binding site [chemical binding]; other site 1017264008794 substrate binding site [chemical binding]; other site 1017264008795 homotetramer interface [polypeptide binding]; other site 1017264008796 catalytic residue [active] 1017264008797 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1017264008798 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1017264008799 Walker A/P-loop; other site 1017264008800 ATP binding site [chemical binding]; other site 1017264008801 Q-loop/lid; other site 1017264008802 ABC transporter signature motif; other site 1017264008803 Walker B; other site 1017264008804 D-loop; other site 1017264008805 H-loop/switch region; other site 1017264008806 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1017264008807 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264008808 Walker A/P-loop; other site 1017264008809 ATP binding site [chemical binding]; other site 1017264008810 Q-loop/lid; other site 1017264008811 ABC transporter signature motif; other site 1017264008812 Walker B; other site 1017264008813 D-loop; other site 1017264008814 H-loop/switch region; other site 1017264008815 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1017264008816 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1017264008817 TM-ABC transporter signature motif; other site 1017264008818 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264008819 TM-ABC transporter signature motif; other site 1017264008820 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1017264008821 homotrimer interaction site [polypeptide binding]; other site 1017264008822 putative active site [active] 1017264008823 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1017264008824 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1017264008825 acyl-activating enzyme (AAE) consensus motif; other site 1017264008826 AMP binding site [chemical binding]; other site 1017264008827 active site 1017264008828 CoA binding site [chemical binding]; other site 1017264008829 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1017264008830 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1017264008831 ligand binding site [chemical binding]; other site 1017264008832 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264008833 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1017264008834 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264008835 short chain dehydrogenase; Provisional; Region: PRK06125 1017264008836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264008837 NAD(P) binding site [chemical binding]; other site 1017264008838 active site 1017264008839 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 1017264008840 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1017264008841 putative active site [active] 1017264008842 putative catalytic site [active] 1017264008843 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1017264008844 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1017264008845 Walker A/P-loop; other site 1017264008846 ATP binding site [chemical binding]; other site 1017264008847 Q-loop/lid; other site 1017264008848 ABC transporter signature motif; other site 1017264008849 Walker B; other site 1017264008850 D-loop; other site 1017264008851 H-loop/switch region; other site 1017264008852 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264008853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264008854 dimer interface [polypeptide binding]; other site 1017264008855 conserved gate region; other site 1017264008856 putative PBP binding loops; other site 1017264008857 ABC-ATPase subunit interface; other site 1017264008858 enoyl-CoA hydratase; Provisional; Region: PRK06127 1017264008859 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264008860 substrate binding site [chemical binding]; other site 1017264008861 oxyanion hole (OAH) forming residues; other site 1017264008862 trimer interface [polypeptide binding]; other site 1017264008863 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264008864 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264008865 Amidase; Region: Amidase; cl11426 1017264008866 Amidase; Region: Amidase; cl11426 1017264008867 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1017264008868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264008869 DNA-binding site [nucleotide binding]; DNA binding site 1017264008870 FCD domain; Region: FCD; pfam07729 1017264008871 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008872 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008873 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008874 Integrase core domain; Region: rve; pfam00665 1017264008875 Integrase core domain; Region: rve_3; pfam13683 1017264008876 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1017264008877 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1017264008878 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1017264008879 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1017264008880 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1017264008881 adenylosuccinate lyase; Provisional; Region: PRK09285 1017264008882 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1017264008883 tetramer interface [polypeptide binding]; other site 1017264008884 active site 1017264008885 putative glutathione S-transferase; Provisional; Region: PRK10357 1017264008886 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1017264008887 putative C-terminal domain interface [polypeptide binding]; other site 1017264008888 putative GSH binding site (G-site) [chemical binding]; other site 1017264008889 putative dimer interface [polypeptide binding]; other site 1017264008890 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1017264008891 dimer interface [polypeptide binding]; other site 1017264008892 N-terminal domain interface [polypeptide binding]; other site 1017264008893 putative substrate binding pocket (H-site) [chemical binding]; other site 1017264008894 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1017264008895 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1017264008896 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1017264008897 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1017264008898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264008899 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264008900 dimerization interface [polypeptide binding]; other site 1017264008901 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264008902 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 1017264008903 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1017264008904 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1017264008905 ligand binding site [chemical binding]; other site 1017264008906 homodimer interface [polypeptide binding]; other site 1017264008907 NAD(P) binding site [chemical binding]; other site 1017264008908 trimer interface B [polypeptide binding]; other site 1017264008909 trimer interface A [polypeptide binding]; other site 1017264008910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1017264008911 outer membrane receptor FepA; Provisional; Region: PRK13528 1017264008912 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264008913 N-terminal plug; other site 1017264008914 ligand-binding site [chemical binding]; other site 1017264008915 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1017264008916 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1017264008917 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1017264008918 Cysteine-rich domain; Region: CCG; pfam02754 1017264008919 Cysteine-rich domain; Region: CCG; pfam02754 1017264008920 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1017264008921 FAD binding domain; Region: FAD_binding_4; pfam01565 1017264008922 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1017264008923 FAD binding domain; Region: FAD_binding_4; pfam01565 1017264008924 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1017264008925 FAD binding domain; Region: FAD_binding_4; pfam01565 1017264008926 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1017264008927 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1017264008928 Peptidase C80 family; Region: Peptidase_C80; pfam11713 1017264008929 Peptidase C80 family; Region: Peptidase_C80; pfam11713 1017264008930 Peptidase C80 family; Region: Peptidase_C80; pfam11713 1017264008931 Peptidase C80 family; Region: Peptidase_C80; pfam11713 1017264008932 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1017264008933 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1017264008934 protease TldD; Provisional; Region: tldD; PRK10735 1017264008935 nitrilase; Region: PLN02798 1017264008936 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1017264008937 putative active site [active] 1017264008938 catalytic triad [active] 1017264008939 dimer interface [polypeptide binding]; other site 1017264008940 H-NS histone family; Region: Histone_HNS; pfam00816 1017264008941 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1017264008942 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264008943 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264008944 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264008945 Integrase core domain; Region: rve; pfam00665 1017264008946 Integrase core domain; Region: rve_3; pfam13683 1017264008947 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1017264008948 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1017264008949 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1017264008950 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1017264008951 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1017264008952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1017264008953 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1017264008954 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1017264008955 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1017264008956 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1017264008957 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1017264008958 Peptidase family M23; Region: Peptidase_M23; pfam01551 1017264008959 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1017264008960 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1017264008961 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1017264008962 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1017264008963 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264008964 N-terminal plug; other site 1017264008965 ligand-binding site [chemical binding]; other site 1017264008966 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1017264008967 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 1017264008968 hypothetical protein; Provisional; Region: PRK05409 1017264008969 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1017264008970 Predicted membrane protein [Function unknown]; Region: COG2259 1017264008971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264008972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1017264008973 putative substrate translocation pore; other site 1017264008974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264008975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264008976 dimerization interface [polypeptide binding]; other site 1017264008977 putative DNA binding site [nucleotide binding]; other site 1017264008978 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1017264008979 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1017264008980 Subunit I/III interface [polypeptide binding]; other site 1017264008981 Subunit III/IV interface [polypeptide binding]; other site 1017264008982 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1017264008983 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1017264008984 D-pathway; other site 1017264008985 Putative ubiquinol binding site [chemical binding]; other site 1017264008986 Low-spin heme (heme b) binding site [chemical binding]; other site 1017264008987 Putative water exit pathway; other site 1017264008988 Binuclear center (heme o3/CuB) [ion binding]; other site 1017264008989 K-pathway; other site 1017264008990 Putative proton exit pathway; other site 1017264008991 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1017264008992 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1017264008993 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1017264008994 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1017264008995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264008996 active site 1017264008997 phosphorylation site [posttranslational modification] 1017264008998 intermolecular recognition site; other site 1017264008999 dimerization interface [polypeptide binding]; other site 1017264009000 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1017264009001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1017264009002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264009003 ATP binding site [chemical binding]; other site 1017264009004 G-X-G motif; other site 1017264009005 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1017264009006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264009007 Pirin-related protein [General function prediction only]; Region: COG1741 1017264009008 Pirin; Region: Pirin; pfam02678 1017264009009 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1017264009010 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264009011 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264009012 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1017264009013 dimerization interface [polypeptide binding]; other site 1017264009014 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264009015 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264009016 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1017264009017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264009018 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1017264009019 dimerization interface [polypeptide binding]; other site 1017264009020 substrate binding pocket [chemical binding]; other site 1017264009021 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264009022 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1017264009023 active site 2 [active] 1017264009024 active site 1 [active] 1017264009025 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264009026 putative DNA binding site [nucleotide binding]; other site 1017264009027 putative Zn2+ binding site [ion binding]; other site 1017264009028 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009029 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009030 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009031 Integrase core domain; Region: rve; pfam00665 1017264009032 Integrase core domain; Region: rve_3; pfam13683 1017264009033 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1017264009034 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1017264009035 catalytic motif [active] 1017264009036 Zn binding site [ion binding]; other site 1017264009037 RibD C-terminal domain; Region: RibD_C; cl17279 1017264009038 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1017264009039 catalytic triad [active] 1017264009040 conserved cis-peptide bond; other site 1017264009041 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1017264009042 ATP cone domain; Region: ATP-cone; pfam03477 1017264009043 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1017264009044 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1017264009045 dimer interface [polypeptide binding]; other site 1017264009046 active site 1017264009047 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1017264009048 folate binding site [chemical binding]; other site 1017264009049 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1017264009050 substrate binding site [chemical binding]; other site 1017264009051 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1017264009052 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1017264009053 active site 1017264009054 HIGH motif; other site 1017264009055 dimer interface [polypeptide binding]; other site 1017264009056 KMSKS motif; other site 1017264009057 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1017264009058 RNA binding surface [nucleotide binding]; other site 1017264009059 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009060 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009061 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009062 Integrase core domain; Region: rve; pfam00665 1017264009063 Integrase core domain; Region: rve_3; pfam13683 1017264009064 putative peptidase; Provisional; Region: PRK11649 1017264009065 Peptidase family M23; Region: Peptidase_M23; pfam01551 1017264009066 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1017264009067 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1017264009068 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1017264009069 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1017264009070 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1017264009071 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1017264009072 23S rRNA interface [nucleotide binding]; other site 1017264009073 L3 interface [polypeptide binding]; other site 1017264009074 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1017264009075 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1017264009076 peptidase PmbA; Provisional; Region: PRK11040 1017264009077 hypothetical protein; Provisional; Region: PRK05255 1017264009078 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1017264009079 putative hydrolase; Provisional; Region: PRK11460 1017264009080 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1017264009081 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1017264009082 Walker A/P-loop; other site 1017264009083 ATP binding site [chemical binding]; other site 1017264009084 Q-loop/lid; other site 1017264009085 ABC transporter signature motif; other site 1017264009086 Walker B; other site 1017264009087 D-loop; other site 1017264009088 H-loop/switch region; other site 1017264009089 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264009090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264009091 dimer interface [polypeptide binding]; other site 1017264009092 conserved gate region; other site 1017264009093 putative PBP binding loops; other site 1017264009094 ABC-ATPase subunit interface; other site 1017264009095 Isochorismatase family; Region: Isochorismatase; pfam00857 1017264009096 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1017264009097 catalytic triad [active] 1017264009098 conserved cis-peptide bond; other site 1017264009099 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1017264009100 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1017264009101 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1017264009102 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1017264009103 ATP binding site [chemical binding]; other site 1017264009104 Mg++ binding site [ion binding]; other site 1017264009105 motif III; other site 1017264009106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1017264009107 nucleotide binding region [chemical binding]; other site 1017264009108 ATP-binding site [chemical binding]; other site 1017264009109 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1017264009110 putative RNA binding site [nucleotide binding]; other site 1017264009111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264009112 DNA-binding site [nucleotide binding]; DNA binding site 1017264009113 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1017264009114 FCD domain; Region: FCD; pfam07729 1017264009115 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009116 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009117 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009118 Integrase core domain; Region: rve; pfam00665 1017264009119 Integrase core domain; Region: rve_3; pfam13683 1017264009120 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1017264009121 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1017264009122 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1017264009123 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1017264009124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1017264009125 Coenzyme A binding pocket [chemical binding]; other site 1017264009126 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1017264009127 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1017264009128 HIGH motif; other site 1017264009129 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1017264009130 active site 1017264009131 KMSKS motif; other site 1017264009132 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1017264009133 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1017264009134 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264009135 putative DNA binding site [nucleotide binding]; other site 1017264009136 putative Zn2+ binding site [ion binding]; other site 1017264009137 AsnC family; Region: AsnC_trans_reg; pfam01037 1017264009138 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1017264009139 ATP cone domain; Region: ATP-cone; pfam03477 1017264009140 ATP cone domain; Region: ATP-cone; pfam03477 1017264009141 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1017264009142 active site 1017264009143 dimer interface [polypeptide binding]; other site 1017264009144 catalytic residues [active] 1017264009145 effector binding site; other site 1017264009146 R2 peptide binding site; other site 1017264009147 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1017264009148 dimer interface [polypeptide binding]; other site 1017264009149 putative radical transfer pathway; other site 1017264009150 diiron center [ion binding]; other site 1017264009151 tyrosyl radical; other site 1017264009152 YGGT family; Region: YGGT; pfam02325 1017264009153 YGGT family; Region: YGGT; pfam02325 1017264009154 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1017264009155 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1017264009156 acyl-activating enzyme (AAE) consensus motif; other site 1017264009157 AMP binding site [chemical binding]; other site 1017264009158 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1017264009159 DltD C-terminal region; Region: DltD_C; pfam04914 1017264009160 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1017264009161 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1017264009162 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1017264009163 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1017264009164 substrate binding site [chemical binding]; other site 1017264009165 ATP binding site [chemical binding]; other site 1017264009166 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1017264009167 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1017264009168 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1017264009169 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1017264009170 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1017264009171 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1017264009172 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1017264009173 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1017264009174 carboxyltransferase (CT) interaction site; other site 1017264009175 biotinylation site [posttranslational modification]; other site 1017264009176 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1017264009177 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1017264009178 trimer interface [polypeptide binding]; other site 1017264009179 active site 1017264009180 dimer interface [polypeptide binding]; other site 1017264009181 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1017264009182 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1017264009183 catalytic residues [active] 1017264009184 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1017264009185 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1017264009186 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1017264009187 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1017264009188 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1017264009189 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1017264009190 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1017264009191 RNB domain; Region: RNB; pfam00773 1017264009192 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1017264009193 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1017264009194 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1017264009195 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1017264009196 shikimate binding site; other site 1017264009197 NAD(P) binding site [chemical binding]; other site 1017264009198 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1017264009199 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1017264009200 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1017264009201 putative active site pocket [active] 1017264009202 dimerization interface [polypeptide binding]; other site 1017264009203 putative catalytic residue [active] 1017264009204 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1017264009205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264009206 putative DNA binding site [nucleotide binding]; other site 1017264009207 putative Zn2+ binding site [ion binding]; other site 1017264009208 AsnC family; Region: AsnC_trans_reg; pfam01037 1017264009209 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1017264009210 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1017264009211 short chain dehydrogenase; Provisional; Region: PRK08339 1017264009212 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1017264009213 putative NAD(P) binding site [chemical binding]; other site 1017264009214 putative active site [active] 1017264009215 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1017264009216 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264009217 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1017264009218 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1017264009219 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1017264009220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1017264009221 nucleotide binding region [chemical binding]; other site 1017264009222 ATP-binding site [chemical binding]; other site 1017264009223 SEC-C motif; Region: SEC-C; pfam02810 1017264009224 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1017264009225 Peptidase family M23; Region: Peptidase_M23; pfam01551 1017264009226 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 1017264009227 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1017264009228 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1017264009229 cell division protein FtsZ; Validated; Region: PRK09330 1017264009230 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1017264009231 nucleotide binding site [chemical binding]; other site 1017264009232 SulA interaction site; other site 1017264009233 cell division protein FtsA; Region: ftsA; TIGR01174 1017264009234 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1017264009235 nucleotide binding site [chemical binding]; other site 1017264009236 Cell division protein FtsA; Region: FtsA; pfam14450 1017264009237 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1017264009238 Cell division protein FtsQ; Region: FtsQ; pfam03799 1017264009239 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1017264009240 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1017264009241 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1017264009242 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1017264009243 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1017264009244 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1017264009245 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1017264009246 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1017264009247 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1017264009248 active site 1017264009249 homodimer interface [polypeptide binding]; other site 1017264009250 cell division protein FtsW; Region: ftsW; TIGR02614 1017264009251 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 1017264009252 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1017264009253 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1017264009254 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1017264009255 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1017264009256 Mg++ binding site [ion binding]; other site 1017264009257 putative catalytic motif [active] 1017264009258 putative substrate binding site [chemical binding]; other site 1017264009259 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 1017264009260 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1017264009261 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1017264009262 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1017264009263 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1017264009264 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1017264009265 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1017264009266 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1017264009267 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1017264009268 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1017264009269 cell division protein FtsL; Region: ftsL_broad; TIGR02209 1017264009270 MraW methylase family; Region: Methyltransf_5; cl17771 1017264009271 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1017264009272 cell division protein MraZ; Reviewed; Region: PRK00326 1017264009273 MraZ protein; Region: MraZ; pfam02381 1017264009274 MraZ protein; Region: MraZ; pfam02381 1017264009275 ABC transporter ATPase component; Reviewed; Region: PRK11147 1017264009276 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1017264009277 ABC transporter; Region: ABC_tran_2; pfam12848 1017264009278 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1017264009279 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1017264009280 active site 1017264009281 substrate binding pocket [chemical binding]; other site 1017264009282 dimer interface [polypeptide binding]; other site 1017264009283 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1017264009284 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1017264009285 metal binding site [ion binding]; metal-binding site 1017264009286 putative dimer interface [polypeptide binding]; other site 1017264009287 SWI complex, BAF60b domains; Region: SWIB; smart00151 1017264009288 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1017264009289 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264009290 dimerization interface [polypeptide binding]; other site 1017264009291 putative DNA binding site [nucleotide binding]; other site 1017264009292 putative Zn2+ binding site [ion binding]; other site 1017264009293 AsnC family; Region: AsnC_trans_reg; pfam01037 1017264009294 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1017264009295 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1017264009296 dimer interface [polypeptide binding]; other site 1017264009297 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1017264009298 active site 1017264009299 Fe binding site [ion binding]; other site 1017264009300 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1017264009301 Cytochrome c; Region: Cytochrom_C; cl11414 1017264009302 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1017264009303 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1017264009304 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009305 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009306 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009307 Integrase core domain; Region: rve; pfam00665 1017264009308 Integrase core domain; Region: rve_3; pfam13683 1017264009309 Cell division protein ZapA; Region: ZapA; pfam05164 1017264009310 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009311 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009312 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009313 Integrase core domain; Region: rve; pfam00665 1017264009314 Integrase core domain; Region: rve_3; pfam13683 1017264009315 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1017264009316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1017264009317 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1017264009318 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1017264009319 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1017264009320 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1017264009321 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009322 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009323 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009324 Integrase core domain; Region: rve; pfam00665 1017264009325 Integrase core domain; Region: rve_3; pfam13683 1017264009326 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1017264009327 ligand binding site [chemical binding]; other site 1017264009328 active site 1017264009329 UGI interface [polypeptide binding]; other site 1017264009330 catalytic site [active] 1017264009331 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1017264009332 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1017264009333 ATP binding site [chemical binding]; other site 1017264009334 Mg++ binding site [ion binding]; other site 1017264009335 motif III; other site 1017264009336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1017264009337 nucleotide binding region [chemical binding]; other site 1017264009338 ATP-binding site [chemical binding]; other site 1017264009339 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1017264009340 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13297 1017264009341 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1017264009342 active site 1017264009343 NTP binding site [chemical binding]; other site 1017264009344 metal binding triad [ion binding]; metal-binding site 1017264009345 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1017264009346 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1017264009347 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1017264009348 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1017264009349 catalytic residue [active] 1017264009350 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1017264009351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264009352 metabolite-proton symporter; Region: 2A0106; TIGR00883 1017264009353 putative substrate translocation pore; other site 1017264009354 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1017264009355 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1017264009356 active site 1017264009357 Zn binding site [ion binding]; other site 1017264009358 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264009359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264009360 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1017264009361 dimerization interface [polypeptide binding]; other site 1017264009362 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009363 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009364 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009365 Integrase core domain; Region: rve; pfam00665 1017264009366 Integrase core domain; Region: rve_3; pfam13683 1017264009367 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1017264009368 FAD binding site [chemical binding]; other site 1017264009369 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1017264009370 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1017264009371 homotetramer interface [polypeptide binding]; other site 1017264009372 ligand binding site [chemical binding]; other site 1017264009373 catalytic site [active] 1017264009374 NAD binding site [chemical binding]; other site 1017264009375 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1017264009376 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1017264009377 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 1017264009378 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1017264009379 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1017264009380 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1017264009381 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1017264009382 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1017264009383 putative acyl-acceptor binding pocket; other site 1017264009384 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1017264009385 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1017264009386 putative acyl-acceptor binding pocket; other site 1017264009387 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1017264009388 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1017264009389 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1017264009390 Protein of unknown function, DUF484; Region: DUF484; cl17449 1017264009391 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1017264009392 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1017264009393 active site 1017264009394 DNA binding site [nucleotide binding] 1017264009395 Int/Topo IB signature motif; other site 1017264009396 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1017264009397 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1017264009398 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1017264009399 High-affinity nickel-transport protein; Region: NicO; cl00964 1017264009400 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 1017264009401 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1017264009402 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1017264009403 metal binding site [ion binding]; metal-binding site 1017264009404 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1017264009405 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1017264009406 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1017264009407 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1017264009408 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1017264009409 metal binding site 2 [ion binding]; metal-binding site 1017264009410 putative DNA binding helix; other site 1017264009411 metal binding site 1 [ion binding]; metal-binding site 1017264009412 dimer interface [polypeptide binding]; other site 1017264009413 structural Zn2+ binding site [ion binding]; other site 1017264009414 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1017264009415 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1017264009416 P-loop, Walker A motif; other site 1017264009417 Base recognition motif; other site 1017264009418 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1017264009419 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1017264009420 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1017264009421 active site 1017264009422 HslU subunit interaction site [polypeptide binding]; other site 1017264009423 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1017264009424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264009425 Walker A motif; other site 1017264009426 ATP binding site [chemical binding]; other site 1017264009427 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1017264009428 Walker B motif; other site 1017264009429 arginine finger; other site 1017264009430 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1017264009431 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1017264009432 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1017264009433 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009434 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009435 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009436 Integrase core domain; Region: rve; pfam00665 1017264009437 Integrase core domain; Region: rve_3; pfam13683 1017264009438 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1017264009439 putative active site [active] 1017264009440 catalytic site [active] 1017264009441 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1017264009442 PLD-like domain; Region: PLDc_2; pfam13091 1017264009443 putative active site [active] 1017264009444 catalytic site [active] 1017264009445 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1017264009446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264009447 Walker A/P-loop; other site 1017264009448 ATP binding site [chemical binding]; other site 1017264009449 Q-loop/lid; other site 1017264009450 ABC transporter signature motif; other site 1017264009451 Walker B; other site 1017264009452 D-loop; other site 1017264009453 H-loop/switch region; other site 1017264009454 TOBE domain; Region: TOBE; cl01440 1017264009455 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1017264009456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264009457 dimer interface [polypeptide binding]; other site 1017264009458 conserved gate region; other site 1017264009459 putative PBP binding loops; other site 1017264009460 ABC-ATPase subunit interface; other site 1017264009461 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1017264009462 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1017264009463 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1017264009464 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1017264009465 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1017264009466 CGNR zinc finger; Region: zf-CGNR; pfam11706 1017264009467 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1017264009468 AsnC family; Region: AsnC_trans_reg; pfam01037 1017264009469 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009470 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009471 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009472 Integrase core domain; Region: rve; pfam00665 1017264009473 Integrase core domain; Region: rve_3; pfam13683 1017264009474 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1017264009475 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1017264009476 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264009477 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1017264009478 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1017264009479 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1017264009480 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1017264009481 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1017264009482 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1017264009483 DNA binding residues [nucleotide binding] 1017264009484 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1017264009485 dimer interface [polypeptide binding]; other site 1017264009486 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1017264009487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1017264009488 non-specific DNA binding site [nucleotide binding]; other site 1017264009489 salt bridge; other site 1017264009490 sequence-specific DNA binding site [nucleotide binding]; other site 1017264009491 Cupin domain; Region: Cupin_2; pfam07883 1017264009492 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009493 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009494 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009495 Integrase core domain; Region: rve; pfam00665 1017264009496 Integrase core domain; Region: rve_3; pfam13683 1017264009497 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009498 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009499 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009500 Integrase core domain; Region: rve; pfam00665 1017264009501 Integrase core domain; Region: rve_3; pfam13683 1017264009502 Predicted ATPase [General function prediction only]; Region: COG4637 1017264009503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264009504 Walker A/P-loop; other site 1017264009505 ATP binding site [chemical binding]; other site 1017264009506 Q-loop/lid; other site 1017264009507 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1017264009508 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 1017264009509 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1017264009510 DNA methylase; Region: N6_N4_Mtase; pfam01555 1017264009511 DNA methylase; Region: N6_N4_Mtase; cl17433 1017264009512 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1017264009513 Fic family protein [Function unknown]; Region: COG3177 1017264009514 Fic/DOC family; Region: Fic; pfam02661 1017264009515 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1017264009516 active site 1017264009517 Int/Topo IB signature motif; other site 1017264009518 GTP-binding protein YchF; Reviewed; Region: PRK09601 1017264009519 YchF GTPase; Region: YchF; cd01900 1017264009520 G1 box; other site 1017264009521 GTP/Mg2+ binding site [chemical binding]; other site 1017264009522 Switch I region; other site 1017264009523 G2 box; other site 1017264009524 Switch II region; other site 1017264009525 G3 box; other site 1017264009526 G4 box; other site 1017264009527 G5 box; other site 1017264009528 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1017264009529 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1017264009530 putative active site [active] 1017264009531 catalytic residue [active] 1017264009532 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1017264009533 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1017264009534 5S rRNA interface [nucleotide binding]; other site 1017264009535 CTC domain interface [polypeptide binding]; other site 1017264009536 L16 interface [polypeptide binding]; other site 1017264009537 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1017264009538 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1017264009539 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1017264009540 active site 1017264009541 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1017264009542 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1017264009543 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1017264009544 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1017264009545 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1017264009546 TPR repeat; Region: TPR_11; pfam13414 1017264009547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1017264009548 binding surface 1017264009549 TPR motif; other site 1017264009550 TPR repeat; Region: TPR_11; pfam13414 1017264009551 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1017264009552 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1017264009553 DNA binding site [nucleotide binding] 1017264009554 catalytic residue [active] 1017264009555 H2TH interface [polypeptide binding]; other site 1017264009556 putative catalytic residues [active] 1017264009557 turnover-facilitating residue; other site 1017264009558 intercalation triad [nucleotide binding]; other site 1017264009559 8OG recognition residue [nucleotide binding]; other site 1017264009560 putative reading head residues; other site 1017264009561 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1017264009562 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1017264009563 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1017264009564 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 1017264009565 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1017264009566 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1017264009567 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 1017264009568 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1017264009569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264009570 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1017264009571 substrate binding pocket [chemical binding]; other site 1017264009572 dimerization interface [polypeptide binding]; other site 1017264009573 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1017264009574 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1017264009575 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1017264009576 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1017264009577 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1017264009578 Sulfatase; Region: Sulfatase; pfam00884 1017264009579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1017264009580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264009581 dimer interface [polypeptide binding]; other site 1017264009582 phosphorylation site [posttranslational modification] 1017264009583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264009584 ATP binding site [chemical binding]; other site 1017264009585 Mg2+ binding site [ion binding]; other site 1017264009586 G-X-G motif; other site 1017264009587 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1017264009588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264009589 active site 1017264009590 phosphorylation site [posttranslational modification] 1017264009591 intermolecular recognition site; other site 1017264009592 dimerization interface [polypeptide binding]; other site 1017264009593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1017264009594 DNA binding site [nucleotide binding] 1017264009595 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1017264009596 FAD binding domain; Region: FAD_binding_4; pfam01565 1017264009597 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1017264009598 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1017264009599 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1017264009600 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1017264009601 active site 1017264009602 substrate binding site [chemical binding]; other site 1017264009603 metal binding site [ion binding]; metal-binding site 1017264009604 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1017264009605 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1017264009606 active site 1017264009607 dimer interface [polypeptide binding]; other site 1017264009608 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1017264009609 dimer interface [polypeptide binding]; other site 1017264009610 active site 1017264009611 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1017264009612 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1017264009613 putative ADP-binding pocket [chemical binding]; other site 1017264009614 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1017264009615 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1017264009616 putative ADP-binding pocket [chemical binding]; other site 1017264009617 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1017264009618 putative ADP-binding pocket [chemical binding]; other site 1017264009619 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1017264009620 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1017264009621 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1017264009622 active site 1017264009623 dimer interface [polypeptide binding]; other site 1017264009624 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1017264009625 Ligand Binding Site [chemical binding]; other site 1017264009626 Molecular Tunnel; other site 1017264009627 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1017264009628 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1017264009629 putative ADP-binding pocket [chemical binding]; other site 1017264009630 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1017264009631 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 1017264009632 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 1017264009633 NAD binding site [chemical binding]; other site 1017264009634 substrate binding site [chemical binding]; other site 1017264009635 homodimer interface [polypeptide binding]; other site 1017264009636 active site 1017264009637 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1017264009638 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1017264009639 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1017264009640 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 1017264009641 Mg++ binding site [ion binding]; other site 1017264009642 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1017264009643 putative catalytic motif [active] 1017264009644 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1017264009645 diiron binding motif [ion binding]; other site 1017264009646 OsmC-like protein; Region: OsmC; cl00767 1017264009647 thymidylate synthase; Provisional; Region: thyA; PRK13821 1017264009648 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1017264009649 dimerization interface [polypeptide binding]; other site 1017264009650 active site 1017264009651 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1017264009652 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1017264009653 folate binding site [chemical binding]; other site 1017264009654 NADP+ binding site [chemical binding]; other site 1017264009655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264009656 DNA-binding site [nucleotide binding]; DNA binding site 1017264009657 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1017264009658 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264009659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264009660 homodimer interface [polypeptide binding]; other site 1017264009661 catalytic residue [active] 1017264009662 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1017264009663 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1017264009664 inhibitor-cofactor binding pocket; inhibition site 1017264009665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264009666 catalytic residue [active] 1017264009667 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1017264009668 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1017264009669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1017264009670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264009671 dimer interface [polypeptide binding]; other site 1017264009672 conserved gate region; other site 1017264009673 putative PBP binding loops; other site 1017264009674 ABC-ATPase subunit interface; other site 1017264009675 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1017264009676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264009677 dimer interface [polypeptide binding]; other site 1017264009678 conserved gate region; other site 1017264009679 putative PBP binding loops; other site 1017264009680 ABC-ATPase subunit interface; other site 1017264009681 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1017264009682 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1017264009683 MlrC C-terminus; Region: MlrC_C; pfam07171 1017264009684 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009685 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009686 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009687 Integrase core domain; Region: rve; pfam00665 1017264009688 Integrase core domain; Region: rve_3; pfam13683 1017264009689 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1017264009690 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1017264009691 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1017264009692 subunit interactions [polypeptide binding]; other site 1017264009693 active site 1017264009694 flap region; other site 1017264009695 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1017264009696 gamma-beta subunit interface [polypeptide binding]; other site 1017264009697 alpha-beta subunit interface [polypeptide binding]; other site 1017264009698 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1017264009699 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1017264009700 alpha-gamma subunit interface [polypeptide binding]; other site 1017264009701 beta-gamma subunit interface [polypeptide binding]; other site 1017264009702 UreD urease accessory protein; Region: UreD; cl00530 1017264009703 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1017264009704 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1017264009705 DNA binding residues [nucleotide binding] 1017264009706 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1017264009707 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1017264009708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264009709 DNA-binding site [nucleotide binding]; DNA binding site 1017264009710 UTRA domain; Region: UTRA; pfam07702 1017264009711 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 1017264009712 dimer interface [polypeptide binding]; other site 1017264009713 Methylaspartate ammonia-lyase C-terminus; Region: MAAL_C; pfam07476 1017264009714 active site 1017264009715 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264009716 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1017264009717 D-galactonate transporter; Region: 2A0114; TIGR00893 1017264009718 SpoVR family protein; Provisional; Region: PRK11767 1017264009719 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1017264009720 hypothetical protein; Provisional; Region: PRK05325 1017264009721 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009722 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009723 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009724 Integrase core domain; Region: rve; pfam00665 1017264009725 Integrase core domain; Region: rve_3; pfam13683 1017264009726 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009727 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009728 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009729 Integrase core domain; Region: rve; pfam00665 1017264009730 Integrase core domain; Region: rve_3; pfam13683 1017264009731 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264009732 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264009733 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1017264009734 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1017264009735 acyl-activating enzyme (AAE) consensus motif; other site 1017264009736 AMP binding site [chemical binding]; other site 1017264009737 active site 1017264009738 CoA binding site [chemical binding]; other site 1017264009739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264009740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264009741 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1017264009742 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1017264009743 active site 1017264009744 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1017264009745 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1017264009746 TM-ABC transporter signature motif; other site 1017264009747 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1017264009748 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264009749 TM-ABC transporter signature motif; other site 1017264009750 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1017264009751 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1017264009752 Walker A/P-loop; other site 1017264009753 ATP binding site [chemical binding]; other site 1017264009754 Q-loop/lid; other site 1017264009755 ABC transporter signature motif; other site 1017264009756 Walker B; other site 1017264009757 D-loop; other site 1017264009758 H-loop/switch region; other site 1017264009759 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1017264009760 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264009761 Walker A/P-loop; other site 1017264009762 ATP binding site [chemical binding]; other site 1017264009763 Q-loop/lid; other site 1017264009764 ABC transporter signature motif; other site 1017264009765 Walker B; other site 1017264009766 D-loop; other site 1017264009767 H-loop/switch region; other site 1017264009768 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1017264009769 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1017264009770 ligand binding site [chemical binding]; other site 1017264009771 enoyl-CoA hydratase; Provisional; Region: PRK08252 1017264009772 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264009773 substrate binding site [chemical binding]; other site 1017264009774 oxyanion hole (OAH) forming residues; other site 1017264009775 trimer interface [polypeptide binding]; other site 1017264009776 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1017264009777 DUF35 OB-fold domain; Region: DUF35; pfam01796 1017264009778 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1017264009779 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1017264009780 dimer interaction site [polypeptide binding]; other site 1017264009781 substrate-binding tunnel; other site 1017264009782 active site 1017264009783 catalytic site [active] 1017264009784 substrate binding site [chemical binding]; other site 1017264009785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264009786 NAD(P) binding site [chemical binding]; other site 1017264009787 active site 1017264009788 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009789 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009790 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009791 Integrase core domain; Region: rve; pfam00665 1017264009792 Integrase core domain; Region: rve_3; pfam13683 1017264009793 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1017264009794 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009795 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009796 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009797 Integrase core domain; Region: rve; pfam00665 1017264009798 Integrase core domain; Region: rve_3; pfam13683 1017264009799 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1017264009800 RNA/DNA hybrid binding site [nucleotide binding]; other site 1017264009801 active site 1017264009802 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1017264009803 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1017264009804 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1017264009805 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1017264009806 catalytic residue [active] 1017264009807 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1017264009808 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1017264009809 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1017264009810 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 1017264009811 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1017264009812 NAD binding site [chemical binding]; other site 1017264009813 homotetramer interface [polypeptide binding]; other site 1017264009814 homodimer interface [polypeptide binding]; other site 1017264009815 substrate binding site [chemical binding]; other site 1017264009816 active site 1017264009817 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264009818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264009819 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264009820 OsmC-like protein; Region: OsmC; pfam02566 1017264009821 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1017264009822 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1017264009823 putative metal binding site [ion binding]; other site 1017264009824 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264009825 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1017264009826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264009827 active site 1017264009828 phosphorylation site [posttranslational modification] 1017264009829 intermolecular recognition site; other site 1017264009830 dimerization interface [polypeptide binding]; other site 1017264009831 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1017264009832 DNA binding site [nucleotide binding] 1017264009833 sensor protein RstB; Provisional; Region: PRK10604 1017264009834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264009835 ATP binding site [chemical binding]; other site 1017264009836 Mg2+ binding site [ion binding]; other site 1017264009837 G-X-G motif; other site 1017264009838 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1017264009839 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1017264009840 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1017264009841 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1017264009842 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1017264009843 active site 1017264009844 HIGH motif; other site 1017264009845 nucleotide binding site [chemical binding]; other site 1017264009846 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1017264009847 KMSKS motif; other site 1017264009848 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1017264009849 septum formation inhibitor; Provisional; Region: minC; PRK00030 1017264009850 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1017264009851 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1017264009852 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1017264009853 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1017264009854 Switch I; other site 1017264009855 Switch II; other site 1017264009856 cell division topological specificity factor MinE; Provisional; Region: PRK13989 1017264009857 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264009858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264009859 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264009860 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1017264009861 EamA-like transporter family; Region: EamA; pfam00892 1017264009862 EamA-like transporter family; Region: EamA; pfam00892 1017264009863 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1017264009864 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1017264009865 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1017264009866 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1017264009867 active site 1017264009868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264009869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264009870 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1017264009871 putative effector binding pocket; other site 1017264009872 dimerization interface [polypeptide binding]; other site 1017264009873 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1017264009874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264009875 Walker A/P-loop; other site 1017264009876 ATP binding site [chemical binding]; other site 1017264009877 Q-loop/lid; other site 1017264009878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264009879 ABC transporter signature motif; other site 1017264009880 Walker B; other site 1017264009881 D-loop; other site 1017264009882 H-loop/switch region; other site 1017264009883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264009884 Walker A/P-loop; other site 1017264009885 ATP binding site [chemical binding]; other site 1017264009886 Q-loop/lid; other site 1017264009887 ABC transporter signature motif; other site 1017264009888 Walker B; other site 1017264009889 D-loop; other site 1017264009890 H-loop/switch region; other site 1017264009891 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1017264009892 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1017264009893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264009894 Walker A/P-loop; other site 1017264009895 ATP binding site [chemical binding]; other site 1017264009896 Q-loop/lid; other site 1017264009897 ABC transporter signature motif; other site 1017264009898 Walker B; other site 1017264009899 D-loop; other site 1017264009900 H-loop/switch region; other site 1017264009901 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1017264009902 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1017264009903 hypothetical protein; Provisional; Region: PRK07546 1017264009904 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1017264009905 substrate-cofactor binding pocket; other site 1017264009906 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264009907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264009908 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264009909 short chain dehydrogenase; Provisional; Region: PRK07577 1017264009910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264009911 NAD(P) binding site [chemical binding]; other site 1017264009912 active site 1017264009913 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264009914 acyl-CoA synthetase; Validated; Region: PRK06164 1017264009915 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1017264009916 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1017264009917 AMP binding site [chemical binding]; other site 1017264009918 active site 1017264009919 acyl-activating enzyme (AAE) consensus motif; other site 1017264009920 CoA binding site [chemical binding]; other site 1017264009921 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1017264009922 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264009923 DNA-binding site [nucleotide binding]; DNA binding site 1017264009924 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1017264009925 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1017264009926 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1017264009927 putative ATP binding site [chemical binding]; other site 1017264009928 putative substrate interface [chemical binding]; other site 1017264009929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264009930 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1017264009931 putative substrate translocation pore; other site 1017264009932 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1017264009933 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1017264009934 putative active site pocket [active] 1017264009935 dimerization interface [polypeptide binding]; other site 1017264009936 putative catalytic residue [active] 1017264009937 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1017264009938 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1017264009939 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1017264009940 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1017264009941 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1017264009942 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1017264009943 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1017264009944 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1017264009945 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1017264009946 putative active site [active] 1017264009947 putative substrate binding site [chemical binding]; other site 1017264009948 putative cosubstrate binding site; other site 1017264009949 catalytic site [active] 1017264009950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264009951 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 1017264009952 putative dimerization interface [polypeptide binding]; other site 1017264009953 putative substrate binding pocket [chemical binding]; other site 1017264009954 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009955 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264009956 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264009957 Integrase core domain; Region: rve; pfam00665 1017264009958 Integrase core domain; Region: rve_3; pfam13683 1017264009959 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1017264009960 active site 1017264009961 ribulose/triose binding site [chemical binding]; other site 1017264009962 phosphate binding site [ion binding]; other site 1017264009963 substrate (anthranilate) binding pocket [chemical binding]; other site 1017264009964 product (indole) binding pocket [chemical binding]; other site 1017264009965 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1017264009966 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1017264009967 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1017264009968 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1017264009969 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1017264009970 glutamine binding [chemical binding]; other site 1017264009971 catalytic triad [active] 1017264009972 anthranilate synthase component I; Provisional; Region: PRK13565 1017264009973 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1017264009974 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1017264009975 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1017264009976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1017264009977 motif II; other site 1017264009978 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1017264009979 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1017264009980 substrate binding site [chemical binding]; other site 1017264009981 hexamer interface [polypeptide binding]; other site 1017264009982 metal binding site [ion binding]; metal-binding site 1017264009983 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1017264009984 MltA specific insert domain; Region: MltA; smart00925 1017264009985 3D domain; Region: 3D; pfam06725 1017264009986 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 1017264009987 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1017264009988 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1017264009989 dimerization domain [polypeptide binding]; other site 1017264009990 dimer interface [polypeptide binding]; other site 1017264009991 catalytic residues [active] 1017264009992 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1017264009993 dimerization interface [polypeptide binding]; other site 1017264009994 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1017264009995 NAD binding site [chemical binding]; other site 1017264009996 ligand binding site [chemical binding]; other site 1017264009997 catalytic site [active] 1017264009998 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264009999 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010000 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010001 Integrase core domain; Region: rve; pfam00665 1017264010002 Integrase core domain; Region: rve_3; pfam13683 1017264010003 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1017264010004 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1017264010005 Ligand Binding Site [chemical binding]; other site 1017264010006 Dihydroneopterin aldolase; Region: FolB; pfam02152 1017264010007 active site 1017264010008 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1017264010009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1017264010010 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1017264010011 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1017264010012 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1017264010013 protein binding site [polypeptide binding]; other site 1017264010014 enoyl-CoA hydratase; Provisional; Region: PRK05862 1017264010015 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264010016 substrate binding site [chemical binding]; other site 1017264010017 oxyanion hole (OAH) forming residues; other site 1017264010018 trimer interface [polypeptide binding]; other site 1017264010019 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1017264010020 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1017264010021 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1017264010022 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1017264010023 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1017264010024 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1017264010025 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1017264010026 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1017264010027 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1017264010028 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1017264010029 beta subunit interaction interface [polypeptide binding]; other site 1017264010030 Walker A motif; other site 1017264010031 ATP binding site [chemical binding]; other site 1017264010032 Walker B motif; other site 1017264010033 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1017264010034 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1017264010035 core domain interface [polypeptide binding]; other site 1017264010036 delta subunit interface [polypeptide binding]; other site 1017264010037 epsilon subunit interface [polypeptide binding]; other site 1017264010038 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1017264010039 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1017264010040 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1017264010041 alpha subunit interaction interface [polypeptide binding]; other site 1017264010042 Walker A motif; other site 1017264010043 ATP binding site [chemical binding]; other site 1017264010044 Walker B motif; other site 1017264010045 inhibitor binding site; inhibition site 1017264010046 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1017264010047 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1017264010048 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1017264010049 gamma subunit interface [polypeptide binding]; other site 1017264010050 epsilon subunit interface [polypeptide binding]; other site 1017264010051 LBP interface [polypeptide binding]; other site 1017264010052 response regulator GlrR; Provisional; Region: PRK15115 1017264010053 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1017264010054 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1017264010055 substrate binding site [chemical binding]; other site 1017264010056 active site 1017264010057 primosome assembly protein PriA; Validated; Region: PRK05580 1017264010058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1017264010059 ATP binding site [chemical binding]; other site 1017264010060 putative Mg++ binding site [ion binding]; other site 1017264010061 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1017264010062 Part of AAA domain; Region: AAA_19; pfam13245 1017264010063 Family description; Region: UvrD_C_2; pfam13538 1017264010064 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010065 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010066 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010067 Integrase core domain; Region: rve; pfam00665 1017264010068 Integrase core domain; Region: rve_3; pfam13683 1017264010069 hypothetical protein; Provisional; Region: PRK07338 1017264010070 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1017264010071 metal binding site [ion binding]; metal-binding site 1017264010072 dimer interface [polypeptide binding]; other site 1017264010073 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1017264010074 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1017264010075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264010076 dimer interface [polypeptide binding]; other site 1017264010077 conserved gate region; other site 1017264010078 putative PBP binding loops; other site 1017264010079 ABC-ATPase subunit interface; other site 1017264010080 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1017264010081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264010082 dimer interface [polypeptide binding]; other site 1017264010083 conserved gate region; other site 1017264010084 putative PBP binding loops; other site 1017264010085 ABC-ATPase subunit interface; other site 1017264010086 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 1017264010087 putative active site [active] 1017264010088 Zn binding site [ion binding]; other site 1017264010089 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1017264010090 putative ATP binding site [chemical binding]; other site 1017264010091 putative substrate binding site [chemical binding]; other site 1017264010092 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264010093 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1017264010094 substrate binding site [chemical binding]; other site 1017264010095 oxyanion hole (OAH) forming residues; other site 1017264010096 trimer interface [polypeptide binding]; other site 1017264010097 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1017264010098 enoyl-CoA hydratase; Provisional; Region: PRK06688 1017264010099 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264010100 substrate binding site [chemical binding]; other site 1017264010101 oxyanion hole (OAH) forming residues; other site 1017264010102 trimer interface [polypeptide binding]; other site 1017264010103 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1017264010104 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1017264010105 FMN binding site [chemical binding]; other site 1017264010106 substrate binding site [chemical binding]; other site 1017264010107 putative catalytic residue [active] 1017264010108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264010109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264010110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1017264010111 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1017264010112 active site 1017264010113 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010114 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010115 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010116 Integrase core domain; Region: rve; pfam00665 1017264010117 Integrase core domain; Region: rve_3; pfam13683 1017264010118 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010119 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1017264010121 Integrase core domain; Region: rve; pfam00665 1017264010122 Integrase core domain; Region: rve_3; pfam13683 1017264010123 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010124 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010125 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010126 Integrase core domain; Region: rve; pfam00665 1017264010127 Integrase core domain; Region: rve_3; pfam13683 1017264010128 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1017264010129 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1017264010130 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1017264010131 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1017264010132 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1017264010133 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1017264010134 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1017264010135 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264010136 substrate binding site [chemical binding]; other site 1017264010137 oxyanion hole (OAH) forming residues; other site 1017264010138 trimer interface [polypeptide binding]; other site 1017264010139 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264010140 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1017264010141 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264010142 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1017264010143 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1017264010144 Amidase; Region: Amidase; pfam01425 1017264010145 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1017264010146 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1017264010147 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010148 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010149 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010150 Integrase core domain; Region: rve; pfam00665 1017264010151 Integrase core domain; Region: rve_3; pfam13683 1017264010152 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 1017264010153 aromatic arch; other site 1017264010154 DCoH dimer interaction site [polypeptide binding]; other site 1017264010155 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1017264010156 DCoH tetramer interaction site [polypeptide binding]; other site 1017264010157 substrate binding site [chemical binding]; other site 1017264010158 hypothetical protein; Validated; Region: PRK09039 1017264010159 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1017264010160 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1017264010161 Substrate binding site; other site 1017264010162 metal-binding site 1017264010163 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1017264010164 Phosphotransferase enzyme family; Region: APH; pfam01636 1017264010165 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1017264010166 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1017264010167 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1017264010168 SurA N-terminal domain; Region: SurA_N; pfam09312 1017264010169 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1017264010170 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1017264010171 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1017264010172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264010173 S-adenosylmethionine binding site [chemical binding]; other site 1017264010174 glycerate kinase; Region: TIGR00045 1017264010175 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1017264010176 pyruvate kinase; Provisional; Region: PRK05826 1017264010177 domain interfaces; other site 1017264010178 active site 1017264010179 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1017264010180 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1017264010181 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010182 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010183 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010184 Integrase core domain; Region: rve; pfam00665 1017264010185 Integrase core domain; Region: rve_3; pfam13683 1017264010186 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1017264010187 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1017264010188 Walker A/P-loop; other site 1017264010189 ATP binding site [chemical binding]; other site 1017264010190 Q-loop/lid; other site 1017264010191 ABC transporter signature motif; other site 1017264010192 Walker B; other site 1017264010193 D-loop; other site 1017264010194 H-loop/switch region; other site 1017264010195 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1017264010196 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1017264010197 ABC-ATPase subunit interface; other site 1017264010198 dimer interface [polypeptide binding]; other site 1017264010199 putative PBP binding regions; other site 1017264010200 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1017264010201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1017264010202 binding surface 1017264010203 TPR motif; other site 1017264010204 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1017264010205 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1017264010206 ligand binding site [chemical binding]; other site 1017264010207 translocation protein TolB; Provisional; Region: tolB; PRK02889 1017264010208 TolB amino-terminal domain; Region: TolB_N; pfam04052 1017264010209 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1017264010210 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1017264010211 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1017264010212 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1017264010213 TolA protein; Region: tolA_full; TIGR02794 1017264010214 TonB C terminal; Region: TonB_2; pfam13103 1017264010215 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1017264010216 TolR protein; Region: tolR; TIGR02801 1017264010217 TolQ protein; Region: tolQ; TIGR02796 1017264010218 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1017264010219 active site 1017264010220 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1017264010221 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1017264010222 dimer interface [polypeptide binding]; other site 1017264010223 motif 1; other site 1017264010224 active site 1017264010225 motif 2; other site 1017264010226 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1017264010227 putative deacylase active site [active] 1017264010228 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1017264010229 active site 1017264010230 motif 3; other site 1017264010231 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1017264010232 anticodon binding site; other site 1017264010233 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1017264010234 putative active site [active] 1017264010235 Ap4A binding site [chemical binding]; other site 1017264010236 nudix motif; other site 1017264010237 putative metal binding site [ion binding]; other site 1017264010238 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1017264010239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264010240 active site 1017264010241 phosphorylation site [posttranslational modification] 1017264010242 intermolecular recognition site; other site 1017264010243 dimerization interface [polypeptide binding]; other site 1017264010244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1017264010245 DNA binding site [nucleotide binding] 1017264010246 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1017264010247 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1017264010248 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1017264010249 catalytic residue [active] 1017264010250 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1017264010251 Phage-related protein, tail component [Function unknown]; Region: COG4733 1017264010252 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1017264010253 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1017264010254 NlpC/P60 family; Region: NLPC_P60; cl17555 1017264010255 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 1017264010256 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1017264010257 Phage-related minor tail protein [Function unknown]; Region: COG5281 1017264010258 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1017264010259 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 1017264010260 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 1017264010261 Phage tail protein; Region: Phage_tail_3; pfam08813 1017264010262 HNH endonuclease; Region: HNH_3; pfam13392 1017264010263 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 1017264010264 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1017264010265 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 1017264010266 Phage terminase large subunit; Region: Terminase_3; cl12054 1017264010267 Terminase-like family; Region: Terminase_6; pfam03237 1017264010268 Transposase; Region: HTH_Tnp_1; cl17663 1017264010269 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010270 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010271 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010272 Integrase core domain; Region: rve; pfam00665 1017264010273 Integrase core domain; Region: rve_3; pfam13683 1017264010274 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1017264010275 Predicted transcriptional regulator [Transcription]; Region: COG2932 1017264010276 Catalytic site [active] 1017264010277 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 1017264010278 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1017264010279 catalytic residues [active] 1017264010280 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1017264010281 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1017264010282 ATP binding site [chemical binding]; other site 1017264010283 Mg++ binding site [ion binding]; other site 1017264010284 motif III; other site 1017264010285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1017264010286 nucleotide binding region [chemical binding]; other site 1017264010287 ATP-binding site [chemical binding]; other site 1017264010288 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1017264010289 AzlC protein; Region: AzlC; pfam03591 1017264010290 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1017264010291 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1017264010292 homodimer interface [polypeptide binding]; other site 1017264010293 substrate-cofactor binding pocket; other site 1017264010294 catalytic residue [active] 1017264010295 Zinc-finger domain; Region: zf-CHCC; cl01821 1017264010296 SnoaL-like domain; Region: SnoaL_3; pfam13474 1017264010297 SnoaL-like domain; Region: SnoaL_2; pfam12680 1017264010298 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1017264010299 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1017264010300 Peptidase family M48; Region: Peptidase_M48; cl12018 1017264010301 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1017264010302 active site 1017264010303 tetramer interface; other site 1017264010304 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1017264010305 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1017264010306 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1017264010307 trimer interface [polypeptide binding]; other site 1017264010308 eyelet of channel; other site 1017264010309 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010310 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010311 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010312 Integrase core domain; Region: rve; pfam00665 1017264010313 Integrase core domain; Region: rve_3; pfam13683 1017264010314 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1017264010315 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1017264010316 proline aminopeptidase P II; Provisional; Region: PRK10879 1017264010317 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1017264010318 active site 1017264010319 hypothetical protein; Provisional; Region: PRK06996 1017264010320 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1017264010321 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1017264010322 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1017264010323 FMN binding site [chemical binding]; other site 1017264010324 active site 1017264010325 catalytic residues [active] 1017264010326 substrate binding site [chemical binding]; other site 1017264010327 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1017264010328 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1017264010329 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1017264010330 purine monophosphate binding site [chemical binding]; other site 1017264010331 dimer interface [polypeptide binding]; other site 1017264010332 putative catalytic residues [active] 1017264010333 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1017264010334 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1017264010335 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1017264010336 active site 1017264010337 putative DNA-binding cleft [nucleotide binding]; other site 1017264010338 dimer interface [polypeptide binding]; other site 1017264010339 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1017264010340 RuvA N terminal domain; Region: RuvA_N; pfam01330 1017264010341 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1017264010342 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1017264010343 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1017264010344 putative NAD(P) binding site [chemical binding]; other site 1017264010345 active site 1017264010346 serine racemase; Region: PLN02970 1017264010347 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1017264010348 tetramer interface [polypeptide binding]; other site 1017264010349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264010350 catalytic residue [active] 1017264010351 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1017264010352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264010353 Walker A motif; other site 1017264010354 ATP binding site [chemical binding]; other site 1017264010355 Walker B motif; other site 1017264010356 arginine finger; other site 1017264010357 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1017264010358 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1017264010359 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1017264010360 ATP binding site [chemical binding]; other site 1017264010361 putative Mg++ binding site [ion binding]; other site 1017264010362 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1017264010363 nucleotide binding region [chemical binding]; other site 1017264010364 ATP-binding site [chemical binding]; other site 1017264010365 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1017264010366 HRDC domain; Region: HRDC; pfam00570 1017264010367 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010368 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010369 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010370 Integrase core domain; Region: rve; pfam00665 1017264010371 Integrase core domain; Region: rve_3; pfam13683 1017264010372 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1017264010373 active site clefts [active] 1017264010374 zinc binding site [ion binding]; other site 1017264010375 dimer interface [polypeptide binding]; other site 1017264010376 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1017264010377 Amidase; Region: Amidase; pfam01425 1017264010378 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1017264010379 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1017264010380 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1017264010381 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1017264010382 TM-ABC transporter signature motif; other site 1017264010383 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264010384 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1017264010385 TM-ABC transporter signature motif; other site 1017264010386 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1017264010387 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264010388 Walker A/P-loop; other site 1017264010389 ATP binding site [chemical binding]; other site 1017264010390 Q-loop/lid; other site 1017264010391 ABC transporter signature motif; other site 1017264010392 Walker B; other site 1017264010393 D-loop; other site 1017264010394 H-loop/switch region; other site 1017264010395 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1017264010396 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1017264010397 Walker A/P-loop; other site 1017264010398 ATP binding site [chemical binding]; other site 1017264010399 Q-loop/lid; other site 1017264010400 ABC transporter signature motif; other site 1017264010401 Walker B; other site 1017264010402 D-loop; other site 1017264010403 H-loop/switch region; other site 1017264010404 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1017264010405 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1017264010406 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1017264010407 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1017264010408 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1017264010409 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1017264010410 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010411 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010412 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010413 Integrase core domain; Region: rve; pfam00665 1017264010414 Integrase core domain; Region: rve_3; pfam13683 1017264010415 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1017264010416 competence damage-inducible protein A; Provisional; Region: PRK01215 1017264010417 putative MPT binding site; other site 1017264010418 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1017264010419 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264010420 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264010421 Rho-activating domain of cytotoxic necrotizing factor; Region: CNF1; pfam05785 1017264010422 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264010423 Phasin protein; Region: Phasin_2; pfam09361 1017264010424 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1017264010425 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1017264010426 quinone interaction residues [chemical binding]; other site 1017264010427 active site 1017264010428 catalytic residues [active] 1017264010429 FMN binding site [chemical binding]; other site 1017264010430 substrate binding site [chemical binding]; other site 1017264010431 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1017264010432 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1017264010433 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1017264010434 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1017264010435 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1017264010436 nudix motif; other site 1017264010437 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264010438 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264010439 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1017264010440 putative effector binding pocket; other site 1017264010441 dimerization interface [polypeptide binding]; other site 1017264010442 DoxX; Region: DoxX; pfam07681 1017264010443 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 1017264010444 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010445 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010446 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010447 Integrase core domain; Region: rve; pfam00665 1017264010448 Integrase core domain; Region: rve_3; pfam13683 1017264010449 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1017264010450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264010451 DNA-binding site [nucleotide binding]; DNA binding site 1017264010452 FCD domain; Region: FCD; pfam07729 1017264010453 thiamine pyrophosphate protein; Validated; Region: PRK08199 1017264010454 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1017264010455 PYR/PP interface [polypeptide binding]; other site 1017264010456 dimer interface [polypeptide binding]; other site 1017264010457 TPP binding site [chemical binding]; other site 1017264010458 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1017264010459 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1017264010460 TPP-binding site [chemical binding]; other site 1017264010461 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264010462 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1017264010463 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1017264010464 active site 1017264010465 iron coordination sites [ion binding]; other site 1017264010466 substrate binding pocket [chemical binding]; other site 1017264010467 malic enzyme; Reviewed; Region: PRK12861 1017264010468 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1017264010469 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1017264010470 putative NAD(P) binding site [chemical binding]; other site 1017264010471 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1017264010472 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1017264010473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264010474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264010475 dimerization interface [polypeptide binding]; other site 1017264010476 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1017264010477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264010478 dimer interface [polypeptide binding]; other site 1017264010479 conserved gate region; other site 1017264010480 putative PBP binding loops; other site 1017264010481 ABC-ATPase subunit interface; other site 1017264010482 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1017264010483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264010484 dimer interface [polypeptide binding]; other site 1017264010485 conserved gate region; other site 1017264010486 putative PBP binding loops; other site 1017264010487 ABC-ATPase subunit interface; other site 1017264010488 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1017264010489 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264010490 Walker A/P-loop; other site 1017264010491 ATP binding site [chemical binding]; other site 1017264010492 Q-loop/lid; other site 1017264010493 ABC transporter signature motif; other site 1017264010494 Walker B; other site 1017264010495 D-loop; other site 1017264010496 H-loop/switch region; other site 1017264010497 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1017264010498 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264010499 Walker A/P-loop; other site 1017264010500 ATP binding site [chemical binding]; other site 1017264010501 Q-loop/lid; other site 1017264010502 ABC transporter signature motif; other site 1017264010503 Walker B; other site 1017264010504 D-loop; other site 1017264010505 H-loop/switch region; other site 1017264010506 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1017264010507 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1017264010508 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1017264010509 MlrC C-terminus; Region: MlrC_C; pfam07171 1017264010510 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264010511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264010512 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1017264010513 dimerization interface [polypeptide binding]; other site 1017264010514 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 1017264010515 putative hydrophobic ligand binding site [chemical binding]; other site 1017264010516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1017264010517 dimerization interface [polypeptide binding]; other site 1017264010518 putative DNA binding site [nucleotide binding]; other site 1017264010519 putative Zn2+ binding site [ion binding]; other site 1017264010520 AsmA family; Region: AsmA; pfam05170 1017264010521 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1017264010522 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1017264010523 Benzoate membrane transport protein; Region: BenE; pfam03594 1017264010524 benzoate transporter; Region: benE; TIGR00843 1017264010525 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1017264010526 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1017264010527 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1017264010528 active site 1017264010529 (T/H)XGH motif; other site 1017264010530 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1017264010531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264010532 S-adenosylmethionine binding site [chemical binding]; other site 1017264010533 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1017264010534 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1017264010535 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1017264010536 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1017264010537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264010538 dimer interface [polypeptide binding]; other site 1017264010539 conserved gate region; other site 1017264010540 ABC-ATPase subunit interface; other site 1017264010541 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1017264010542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1017264010543 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010544 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010545 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010546 Integrase core domain; Region: rve; pfam00665 1017264010547 Integrase core domain; Region: rve_3; pfam13683 1017264010548 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1017264010549 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264010550 substrate binding pocket [chemical binding]; other site 1017264010551 membrane-bound complex binding site; other site 1017264010552 hinge residues; other site 1017264010553 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1017264010554 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1017264010555 Bacterial transcriptional regulator; Region: IclR; pfam01614 1017264010556 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1017264010557 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1017264010558 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1017264010559 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1017264010560 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1017264010561 dimerization interface [polypeptide binding]; other site 1017264010562 active site 1017264010563 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1017264010564 homopentamer interface [polypeptide binding]; other site 1017264010565 active site 1017264010566 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1017264010567 thiamine monophosphate kinase; Provisional; Region: PRK05731 1017264010568 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1017264010569 ATP binding site [chemical binding]; other site 1017264010570 dimerization interface [polypeptide binding]; other site 1017264010571 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1017264010572 tetramer interfaces [polypeptide binding]; other site 1017264010573 binuclear metal-binding site [ion binding]; other site 1017264010574 Competence-damaged protein; Region: CinA; pfam02464 1017264010575 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1017264010576 active site 1017264010577 dimer interface [polypeptide binding]; other site 1017264010578 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1017264010579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1017264010580 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1017264010581 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1017264010582 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1017264010583 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1017264010584 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1017264010585 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1017264010586 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1017264010587 ring oligomerisation interface [polypeptide binding]; other site 1017264010588 ATP/Mg binding site [chemical binding]; other site 1017264010589 stacking interactions; other site 1017264010590 hinge regions; other site 1017264010591 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1017264010592 oligomerisation interface [polypeptide binding]; other site 1017264010593 mobile loop; other site 1017264010594 roof hairpin; other site 1017264010595 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1017264010596 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 1017264010597 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1017264010598 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264010599 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264010600 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264010601 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1017264010602 dimerization interface [polypeptide binding]; other site 1017264010603 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 1017264010604 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1017264010605 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010606 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010607 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010608 Integrase core domain; Region: rve; pfam00665 1017264010609 Integrase core domain; Region: rve_3; pfam13683 1017264010610 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1017264010611 Isochorismatase family; Region: Isochorismatase; pfam00857 1017264010612 catalytic triad [active] 1017264010613 metal binding site [ion binding]; metal-binding site 1017264010614 conserved cis-peptide bond; other site 1017264010615 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1017264010616 heme-binding site [chemical binding]; other site 1017264010617 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1017264010618 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1017264010619 metal binding site [ion binding]; metal-binding site 1017264010620 active site 1017264010621 I-site; other site 1017264010622 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1017264010623 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1017264010624 Zn2+ binding site [ion binding]; other site 1017264010625 Mg2+ binding site [ion binding]; other site 1017264010626 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1017264010627 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1017264010628 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1017264010629 PLD-like domain; Region: PLDc_2; pfam13091 1017264010630 putative active site [active] 1017264010631 catalytic site [active] 1017264010632 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1017264010633 PLD-like domain; Region: PLDc_2; pfam13091 1017264010634 putative active site [active] 1017264010635 catalytic site [active] 1017264010636 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010637 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010638 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010639 Integrase core domain; Region: rve; pfam00665 1017264010640 Integrase core domain; Region: rve_3; pfam13683 1017264010641 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010642 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010643 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010644 Integrase core domain; Region: rve; pfam00665 1017264010645 Integrase core domain; Region: rve_3; pfam13683 1017264010646 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1017264010647 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1017264010648 active site 1017264010649 FMN binding site [chemical binding]; other site 1017264010650 substrate binding site [chemical binding]; other site 1017264010651 3Fe-4S cluster binding site [ion binding]; other site 1017264010652 Sulphur transport; Region: Sulf_transp; pfam04143 1017264010653 Predicted permeases [General function prediction only]; Region: COG0679 1017264010654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1017264010655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1017264010656 Coenzyme A binding pocket [chemical binding]; other site 1017264010657 DTW domain; Region: DTW; cl01221 1017264010658 ribonuclease R; Region: RNase_R; TIGR02063 1017264010659 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1017264010660 RNA binding site [nucleotide binding]; other site 1017264010661 RNB domain; Region: RNB; pfam00773 1017264010662 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1017264010663 RNA binding site [nucleotide binding]; other site 1017264010664 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1017264010665 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1017264010666 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1017264010667 hypothetical protein; Provisional; Region: PRK05939 1017264010668 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1017264010669 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1017264010670 catalytic residue [active] 1017264010671 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1017264010672 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1017264010673 IHF dimer interface [polypeptide binding]; other site 1017264010674 IHF - DNA interface [nucleotide binding]; other site 1017264010675 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1017264010676 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1017264010677 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1017264010678 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1017264010679 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1017264010680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264010681 active site 1017264010682 phosphorylation site [posttranslational modification] 1017264010683 intermolecular recognition site; other site 1017264010684 dimerization interface [polypeptide binding]; other site 1017264010685 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1017264010686 DNA binding site [nucleotide binding] 1017264010687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264010688 dimer interface [polypeptide binding]; other site 1017264010689 phosphorylation site [posttranslational modification] 1017264010690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264010691 ATP binding site [chemical binding]; other site 1017264010692 Mg2+ binding site [ion binding]; other site 1017264010693 G-X-G motif; other site 1017264010694 K+ potassium transporter; Region: K_trans; cl15781 1017264010695 potassium uptake protein; Region: kup; TIGR00794 1017264010696 argininosuccinate synthase; Validated; Region: PRK05370 1017264010697 argininosuccinate synthase; Provisional; Region: PRK13820 1017264010698 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1017264010699 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1017264010700 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1017264010701 acetylornithine aminotransferase; Provisional; Region: PRK02627 1017264010702 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1017264010703 inhibitor-cofactor binding pocket; inhibition site 1017264010704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264010705 catalytic residue [active] 1017264010706 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 1017264010707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264010708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264010709 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1017264010710 putative effector binding pocket; other site 1017264010711 putative dimerization interface [polypeptide binding]; other site 1017264010712 short chain dehydrogenase; Provisional; Region: PRK12744 1017264010713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1017264010714 NAD(P) binding site [chemical binding]; other site 1017264010715 active site 1017264010716 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1017264010717 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1017264010718 putative ligand binding site [chemical binding]; other site 1017264010719 NAD binding site [chemical binding]; other site 1017264010720 catalytic site [active] 1017264010721 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264010722 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1017264010723 inhibitor site; inhibition site 1017264010724 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1017264010725 active site 1017264010726 dimer interface [polypeptide binding]; other site 1017264010727 catalytic residue [active] 1017264010728 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1017264010729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264010730 DNA-binding site [nucleotide binding]; DNA binding site 1017264010731 FCD domain; Region: FCD; pfam07729 1017264010732 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010733 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010734 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010735 Integrase core domain; Region: rve; pfam00665 1017264010736 Integrase core domain; Region: rve_3; pfam13683 1017264010737 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1017264010738 Helix-turn-helix domain; Region: HTH_18; pfam12833 1017264010739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1017264010740 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1017264010741 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1017264010742 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1017264010743 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1017264010744 dimer interface [polypeptide binding]; other site 1017264010745 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1017264010746 catalytic triad [active] 1017264010747 peroxidatic and resolving cysteines [active] 1017264010748 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1017264010749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264010750 active site 1017264010751 phosphorylation site [posttranslational modification] 1017264010752 intermolecular recognition site; other site 1017264010753 dimerization interface [polypeptide binding]; other site 1017264010754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1017264010755 DNA binding site [nucleotide binding] 1017264010756 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1017264010757 Glycoprotease family; Region: Peptidase_M22; pfam00814 1017264010758 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1017264010759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1017264010760 Coenzyme A binding pocket [chemical binding]; other site 1017264010761 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1017264010762 Fe-S cluster binding site [ion binding]; other site 1017264010763 active site 1017264010764 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1017264010765 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1017264010766 AAA domain; Region: AAA_23; pfam13476 1017264010767 Walker A/P-loop; other site 1017264010768 ATP binding site [chemical binding]; other site 1017264010769 Q-loop/lid; other site 1017264010770 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1017264010771 ABC transporter signature motif; other site 1017264010772 Walker B; other site 1017264010773 D-loop; other site 1017264010774 H-loop/switch region; other site 1017264010775 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 1017264010776 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1017264010777 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1017264010778 nucleotide binding pocket [chemical binding]; other site 1017264010779 K-X-D-G motif; other site 1017264010780 catalytic site [active] 1017264010781 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1017264010782 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1017264010783 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1017264010784 Dimer interface [polypeptide binding]; other site 1017264010785 BRCT sequence motif; other site 1017264010786 SurA N-terminal domain; Region: SurA_N_3; cl07813 1017264010787 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 1017264010788 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1017264010789 BolA-like protein; Region: BolA; pfam01722 1017264010790 intracellular septation protein A; Reviewed; Region: PRK00259 1017264010791 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1017264010792 SelR domain; Region: SelR; pfam01641 1017264010793 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1017264010794 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1017264010795 Walker A/P-loop; other site 1017264010796 ATP binding site [chemical binding]; other site 1017264010797 Q-loop/lid; other site 1017264010798 ABC transporter signature motif; other site 1017264010799 Walker B; other site 1017264010800 D-loop; other site 1017264010801 H-loop/switch region; other site 1017264010802 Cobalt transport protein; Region: CbiQ; cl00463 1017264010803 BioY family; Region: BioY; pfam02632 1017264010804 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1017264010805 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1017264010806 putative ligand binding site [chemical binding]; other site 1017264010807 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264010808 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1017264010809 TM-ABC transporter signature motif; other site 1017264010810 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1017264010811 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1017264010812 TM-ABC transporter signature motif; other site 1017264010813 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1017264010814 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264010815 Walker A/P-loop; other site 1017264010816 ATP binding site [chemical binding]; other site 1017264010817 Q-loop/lid; other site 1017264010818 ABC transporter signature motif; other site 1017264010819 Walker B; other site 1017264010820 D-loop; other site 1017264010821 H-loop/switch region; other site 1017264010822 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1017264010823 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1017264010824 homodimer interface [polypeptide binding]; other site 1017264010825 substrate-cofactor binding pocket; other site 1017264010826 catalytic residue [active] 1017264010827 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1017264010828 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1017264010829 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1017264010830 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1017264010831 TM-ABC transporter signature motif; other site 1017264010832 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264010833 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1017264010834 TM-ABC transporter signature motif; other site 1017264010835 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1017264010836 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1017264010837 putative ligand binding site [chemical binding]; other site 1017264010838 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1017264010839 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1017264010840 Walker A/P-loop; other site 1017264010841 ATP binding site [chemical binding]; other site 1017264010842 Q-loop/lid; other site 1017264010843 ABC transporter signature motif; other site 1017264010844 Walker B; other site 1017264010845 D-loop; other site 1017264010846 H-loop/switch region; other site 1017264010847 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1017264010848 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264010849 Walker A/P-loop; other site 1017264010850 ATP binding site [chemical binding]; other site 1017264010851 Q-loop/lid; other site 1017264010852 ABC transporter signature motif; other site 1017264010853 Walker B; other site 1017264010854 D-loop; other site 1017264010855 H-loop/switch region; other site 1017264010856 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1017264010857 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1017264010858 minor groove reading motif; other site 1017264010859 helix-hairpin-helix signature motif; other site 1017264010860 substrate binding pocket [chemical binding]; other site 1017264010861 active site 1017264010862 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1017264010863 ferredoxin; Provisional; Region: PRK08764 1017264010864 Putative Fe-S cluster; Region: FeS; cl17515 1017264010865 4Fe-4S binding domain; Region: Fer4; cl02805 1017264010866 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 1017264010867 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1017264010868 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1017264010869 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1017264010870 FAD binding pocket [chemical binding]; other site 1017264010871 FAD binding motif [chemical binding]; other site 1017264010872 phosphate binding motif [ion binding]; other site 1017264010873 beta-alpha-beta structure motif; other site 1017264010874 NAD binding pocket [chemical binding]; other site 1017264010875 Ferredoxin [Energy production and conversion]; Region: COG1146 1017264010876 4Fe-4S binding domain; Region: Fer4; cl02805 1017264010877 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1017264010878 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1017264010879 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1017264010880 active site 1017264010881 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1017264010882 homotrimer interaction site [polypeptide binding]; other site 1017264010883 putative active site [active] 1017264010884 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1017264010885 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1017264010886 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1017264010887 HD domain; Region: HD_4; pfam13328 1017264010888 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1017264010889 synthetase active site [active] 1017264010890 NTP binding site [chemical binding]; other site 1017264010891 metal binding site [ion binding]; metal-binding site 1017264010892 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1017264010893 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1017264010894 acetylornithine deacetylase; Provisional; Region: PRK07522 1017264010895 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1017264010896 metal binding site [ion binding]; metal-binding site 1017264010897 putative dimer interface [polypeptide binding]; other site 1017264010898 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1017264010899 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1017264010900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264010901 catalytic residue [active] 1017264010902 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1017264010903 substrate binding site [chemical binding]; other site 1017264010904 active site 1017264010905 catalytic residues [active] 1017264010906 heterodimer interface [polypeptide binding]; other site 1017264010907 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1017264010908 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1017264010909 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010910 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010911 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010912 Integrase core domain; Region: rve; pfam00665 1017264010913 Integrase core domain; Region: rve_3; pfam13683 1017264010914 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1017264010915 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1017264010916 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1017264010917 substrate binding pocket [chemical binding]; other site 1017264010918 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1017264010919 B12 binding site [chemical binding]; other site 1017264010920 cobalt ligand [ion binding]; other site 1017264010921 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1017264010922 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1017264010923 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264010924 N-terminal plug; other site 1017264010925 ligand-binding site [chemical binding]; other site 1017264010926 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1017264010927 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1017264010928 cobalamin binding residues [chemical binding]; other site 1017264010929 putative BtuC binding residues; other site 1017264010930 dimer interface [polypeptide binding]; other site 1017264010931 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1017264010932 ThiS interaction site; other site 1017264010933 putative active site [active] 1017264010934 tetramer interface [polypeptide binding]; other site 1017264010935 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1017264010936 dimer interface [polypeptide binding]; other site 1017264010937 substrate binding site [chemical binding]; other site 1017264010938 ATP binding site [chemical binding]; other site 1017264010939 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1017264010940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264010941 S-adenosylmethionine binding site [chemical binding]; other site 1017264010942 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1017264010943 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1017264010944 active site 1017264010945 nucleotide binding site [chemical binding]; other site 1017264010946 HIGH motif; other site 1017264010947 KMSKS motif; other site 1017264010948 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1017264010949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1017264010950 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1017264010951 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1017264010952 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1017264010953 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1017264010954 voltage-gated potassium channel; Provisional; Region: PRK10537 1017264010955 Ion channel; Region: Ion_trans_2; pfam07885 1017264010956 TrkA-N domain; Region: TrkA_N; pfam02254 1017264010957 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264010958 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264010959 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264010960 Integrase core domain; Region: rve; pfam00665 1017264010961 Integrase core domain; Region: rve_3; pfam13683 1017264010962 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1017264010963 S17 interaction site [polypeptide binding]; other site 1017264010964 S8 interaction site; other site 1017264010965 16S rRNA interaction site [nucleotide binding]; other site 1017264010966 streptomycin interaction site [chemical binding]; other site 1017264010967 23S rRNA interaction site [nucleotide binding]; other site 1017264010968 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1017264010969 30S ribosomal protein S7; Validated; Region: PRK05302 1017264010970 elongation factor G; Reviewed; Region: PRK00007 1017264010971 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1017264010972 G1 box; other site 1017264010973 putative GEF interaction site [polypeptide binding]; other site 1017264010974 GTP/Mg2+ binding site [chemical binding]; other site 1017264010975 Switch I region; other site 1017264010976 G2 box; other site 1017264010977 G3 box; other site 1017264010978 Switch II region; other site 1017264010979 G4 box; other site 1017264010980 G5 box; other site 1017264010981 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1017264010982 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1017264010983 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1017264010984 elongation factor Tu; Reviewed; Region: PRK00049 1017264010985 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1017264010986 G1 box; other site 1017264010987 GEF interaction site [polypeptide binding]; other site 1017264010988 GTP/Mg2+ binding site [chemical binding]; other site 1017264010989 Switch I region; other site 1017264010990 G2 box; other site 1017264010991 G3 box; other site 1017264010992 Switch II region; other site 1017264010993 G4 box; other site 1017264010994 G5 box; other site 1017264010995 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1017264010996 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1017264010997 Antibiotic Binding Site [chemical binding]; other site 1017264010998 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1017264010999 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1017264011000 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1017264011001 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1017264011002 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1017264011003 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1017264011004 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1017264011005 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1017264011006 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1017264011007 putative translocon binding site; other site 1017264011008 protein-rRNA interface [nucleotide binding]; other site 1017264011009 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1017264011010 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1017264011011 G-X-X-G motif; other site 1017264011012 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1017264011013 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1017264011014 23S rRNA interface [nucleotide binding]; other site 1017264011015 5S rRNA interface [nucleotide binding]; other site 1017264011016 putative antibiotic binding site [chemical binding]; other site 1017264011017 L25 interface [polypeptide binding]; other site 1017264011018 L27 interface [polypeptide binding]; other site 1017264011019 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1017264011020 23S rRNA interface [nucleotide binding]; other site 1017264011021 putative translocon interaction site; other site 1017264011022 signal recognition particle (SRP54) interaction site; other site 1017264011023 L23 interface [polypeptide binding]; other site 1017264011024 trigger factor interaction site; other site 1017264011025 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1017264011026 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1017264011027 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1017264011028 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1017264011029 tetramerization interface [polypeptide binding]; other site 1017264011030 NAD(P) binding site [chemical binding]; other site 1017264011031 catalytic residues [active] 1017264011032 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1017264011033 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1017264011034 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1017264011035 RNA binding site [nucleotide binding]; other site 1017264011036 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1017264011037 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1017264011038 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1017264011039 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1017264011040 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1017264011041 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1017264011042 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1017264011043 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1017264011044 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1017264011045 5S rRNA interface [nucleotide binding]; other site 1017264011046 L27 interface [polypeptide binding]; other site 1017264011047 23S rRNA interface [nucleotide binding]; other site 1017264011048 L5 interface [polypeptide binding]; other site 1017264011049 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1017264011050 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1017264011051 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1017264011052 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1017264011053 23S rRNA binding site [nucleotide binding]; other site 1017264011054 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1017264011055 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1017264011056 SecY translocase; Region: SecY; pfam00344 1017264011057 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1017264011058 rRNA binding site [nucleotide binding]; other site 1017264011059 predicted 30S ribosome binding site; other site 1017264011060 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1017264011061 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1017264011062 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1017264011063 30S ribosomal protein S11; Validated; Region: PRK05309 1017264011064 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1017264011065 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1017264011066 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1017264011067 RNA binding surface [nucleotide binding]; other site 1017264011068 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1017264011069 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1017264011070 alphaNTD homodimer interface [polypeptide binding]; other site 1017264011071 alphaNTD - beta interaction site [polypeptide binding]; other site 1017264011072 alphaNTD - beta' interaction site [polypeptide binding]; other site 1017264011073 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1017264011074 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1017264011075 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1017264011076 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1017264011077 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1017264011078 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1017264011079 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1017264011080 DsbD alpha interface [polypeptide binding]; other site 1017264011081 catalytic residues [active] 1017264011082 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1017264011083 EamA-like transporter family; Region: EamA; pfam00892 1017264011084 EamA-like transporter family; Region: EamA; pfam00892 1017264011085 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1017264011086 dimer interface [polypeptide binding]; other site 1017264011087 active site 1017264011088 aspartate-rich active site metal binding site; other site 1017264011089 allosteric magnesium binding site [ion binding]; other site 1017264011090 Schiff base residues; other site 1017264011091 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1017264011092 G1 box; other site 1017264011093 GTP/Mg2+ binding site [chemical binding]; other site 1017264011094 Switch I region; other site 1017264011095 G2 box; other site 1017264011096 G3 box; other site 1017264011097 Switch II region; other site 1017264011098 G4 box; other site 1017264011099 G5 box; other site 1017264011100 Cytochrome c; Region: Cytochrom_C; cl11414 1017264011101 Cytochrome c; Region: Cytochrom_C; cl11414 1017264011102 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1017264011103 ResB-like family; Region: ResB; pfam05140 1017264011104 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1017264011105 ResB-like family; Region: ResB; pfam05140 1017264011106 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1017264011107 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1017264011108 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1017264011109 active site 1017264011110 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1017264011111 substrate binding site [chemical binding]; other site 1017264011112 catalytic residues [active] 1017264011113 dimer interface [polypeptide binding]; other site 1017264011114 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1017264011115 putative iron binding site [ion binding]; other site 1017264011116 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1017264011117 Transglycosylase; Region: Transgly; pfam00912 1017264011118 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1017264011119 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1017264011120 shikimate kinase; Reviewed; Region: aroK; PRK00131 1017264011121 ADP binding site [chemical binding]; other site 1017264011122 magnesium binding site [ion binding]; other site 1017264011123 putative shikimate binding site; other site 1017264011124 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1017264011125 active site 1017264011126 dimer interface [polypeptide binding]; other site 1017264011127 metal binding site [ion binding]; metal-binding site 1017264011128 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1017264011129 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1017264011130 Zn2+ binding site [ion binding]; other site 1017264011131 Mg2+ binding site [ion binding]; other site 1017264011132 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1017264011133 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1017264011134 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1017264011135 putative C-terminal domain interface [polypeptide binding]; other site 1017264011136 putative GSH binding site (G-site) [chemical binding]; other site 1017264011137 putative dimer interface [polypeptide binding]; other site 1017264011138 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1017264011139 putative substrate binding pocket (H-site) [chemical binding]; other site 1017264011140 putative N-terminal domain interface [polypeptide binding]; other site 1017264011141 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1017264011142 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1017264011143 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1017264011144 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1017264011145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264011146 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1017264011147 putative substrate translocation pore; other site 1017264011148 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1017264011149 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1017264011150 dimer interface [polypeptide binding]; other site 1017264011151 ssDNA binding site [nucleotide binding]; other site 1017264011152 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1017264011153 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1017264011154 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1017264011155 N-terminal plug; other site 1017264011156 ligand-binding site [chemical binding]; other site 1017264011157 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1017264011158 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264011159 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1017264011160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264011161 DNA-binding site [nucleotide binding]; DNA binding site 1017264011162 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1017264011163 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264011164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264011165 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1017264011166 substrate binding pocket [chemical binding]; other site 1017264011167 dimerization interface [polypeptide binding]; other site 1017264011168 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 1017264011169 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1017264011170 active site 1017264011171 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264011172 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1017264011173 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1017264011174 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; pfam10707 1017264011175 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264011176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264011177 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1017264011178 dimerization interface [polypeptide binding]; other site 1017264011179 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1017264011180 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1017264011181 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264011182 membrane-bound complex binding site; other site 1017264011183 hinge residues; other site 1017264011184 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264011185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264011186 dimer interface [polypeptide binding]; other site 1017264011187 conserved gate region; other site 1017264011188 putative PBP binding loops; other site 1017264011189 ABC-ATPase subunit interface; other site 1017264011190 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1017264011191 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1017264011192 Walker A/P-loop; other site 1017264011193 ATP binding site [chemical binding]; other site 1017264011194 Q-loop/lid; other site 1017264011195 ABC transporter signature motif; other site 1017264011196 Walker B; other site 1017264011197 D-loop; other site 1017264011198 H-loop/switch region; other site 1017264011199 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1017264011200 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1017264011201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264011202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264011203 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1017264011204 malate synthase G; Provisional; Region: PRK02999 1017264011205 active site 1017264011206 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1017264011207 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 1017264011208 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1017264011209 UbiA prenyltransferase family; Region: UbiA; pfam01040 1017264011210 aspartate aminotransferase; Provisional; Region: PRK05764 1017264011211 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264011212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264011213 homodimer interface [polypeptide binding]; other site 1017264011214 catalytic residue [active] 1017264011215 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1017264011216 GAF domain; Region: GAF_2; pfam13185 1017264011217 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1017264011218 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1017264011219 dimer interface [polypeptide binding]; other site 1017264011220 active site 1017264011221 catalytic residue [active] 1017264011222 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1017264011223 BON domain; Region: BON; pfam04972 1017264011224 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1017264011225 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1017264011226 thiS-thiF/thiG interaction site; other site 1017264011227 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1017264011228 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1017264011229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264011230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264011231 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1017264011232 putative dimerization interface [polypeptide binding]; other site 1017264011233 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1017264011234 active site 1017264011235 catalytic residues [active] 1017264011236 metal binding site [ion binding]; metal-binding site 1017264011237 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264011238 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264011239 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264011240 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264011241 Integrase core domain; Region: rve; pfam00665 1017264011242 Integrase core domain; Region: rve_3; pfam13683 1017264011243 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1017264011244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264011245 DNA-binding site [nucleotide binding]; DNA binding site 1017264011246 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264011247 NMT1-like family; Region: NMT1_2; pfam13379 1017264011248 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1017264011249 substrate binding pocket [chemical binding]; other site 1017264011250 membrane-bound complex binding site; other site 1017264011251 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1017264011252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1017264011253 DNA-binding site [nucleotide binding]; DNA binding site 1017264011254 UTRA domain; Region: UTRA; cl17743 1017264011255 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264011256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1017264011257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264011258 ABC-ATPase subunit interface; other site 1017264011259 NMT1/THI5 like; Region: NMT1; pfam09084 1017264011260 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1017264011261 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1017264011262 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1017264011263 Walker A/P-loop; other site 1017264011264 ATP binding site [chemical binding]; other site 1017264011265 Q-loop/lid; other site 1017264011266 ABC transporter signature motif; other site 1017264011267 Walker B; other site 1017264011268 D-loop; other site 1017264011269 H-loop/switch region; other site 1017264011270 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264011271 enoyl-CoA hydratase; Provisional; Region: PRK06494 1017264011272 substrate binding site [chemical binding]; other site 1017264011273 oxyanion hole (OAH) forming residues; other site 1017264011274 trimer interface [polypeptide binding]; other site 1017264011275 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1017264011276 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264011277 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1017264011278 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1017264011279 NAD(P) binding site [chemical binding]; other site 1017264011280 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264011281 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264011282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264011283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264011284 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1017264011285 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1017264011286 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1017264011287 putative NADH binding site [chemical binding]; other site 1017264011288 putative active site [active] 1017264011289 nudix motif; other site 1017264011290 putative metal binding site [ion binding]; other site 1017264011291 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1017264011292 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1017264011293 FMN-binding pocket [chemical binding]; other site 1017264011294 flavin binding motif; other site 1017264011295 phosphate binding motif [ion binding]; other site 1017264011296 beta-alpha-beta structure motif; other site 1017264011297 NAD binding pocket [chemical binding]; other site 1017264011298 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1017264011299 catalytic loop [active] 1017264011300 iron binding site [ion binding]; other site 1017264011301 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1017264011302 Amidase; Region: Amidase; cl11426 1017264011303 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1017264011304 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1017264011305 NAD(P) binding site [chemical binding]; other site 1017264011306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1017264011307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1017264011308 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1017264011309 putative substrate binding pocket [chemical binding]; other site 1017264011310 dimerization interface [polypeptide binding]; other site 1017264011311 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1017264011312 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1017264011313 putative ligand binding site [chemical binding]; other site 1017264011314 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1017264011315 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1017264011316 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1017264011317 Walker A/P-loop; other site 1017264011318 ATP binding site [chemical binding]; other site 1017264011319 Q-loop/lid; other site 1017264011320 ABC transporter signature motif; other site 1017264011321 Walker B; other site 1017264011322 D-loop; other site 1017264011323 H-loop/switch region; other site 1017264011324 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1017264011325 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1017264011326 Walker A/P-loop; other site 1017264011327 ATP binding site [chemical binding]; other site 1017264011328 Q-loop/lid; other site 1017264011329 ABC transporter signature motif; other site 1017264011330 Walker B; other site 1017264011331 D-loop; other site 1017264011332 H-loop/switch region; other site 1017264011333 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1017264011334 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1017264011335 TM-ABC transporter signature motif; other site 1017264011336 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1017264011337 TM-ABC transporter signature motif; other site 1017264011338 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 1017264011339 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1017264011340 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1017264011341 alpha subunit interface [polypeptide binding]; other site 1017264011342 active site 1017264011343 substrate binding site [chemical binding]; other site 1017264011344 Fe binding site [ion binding]; other site 1017264011345 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1017264011346 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 1017264011347 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1017264011348 dimerization interface [polypeptide binding]; other site 1017264011349 active site 1017264011350 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264011351 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264011352 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264011353 Integrase core domain; Region: rve; pfam00665 1017264011354 Integrase core domain; Region: rve_3; pfam13683 1017264011355 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1017264011356 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1017264011357 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1017264011358 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1017264011359 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1017264011360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264011361 putative substrate translocation pore; other site 1017264011362 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1017264011363 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1017264011364 Substrate binding site; other site 1017264011365 Mg++ binding site; other site 1017264011366 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1017264011367 active site 1017264011368 substrate binding site [chemical binding]; other site 1017264011369 CoA binding site [chemical binding]; other site 1017264011370 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 1017264011371 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1017264011372 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1017264011373 Cu(I) binding site [ion binding]; other site 1017264011374 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1017264011375 UbiA prenyltransferase family; Region: UbiA; pfam01040 1017264011376 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1017264011377 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1017264011378 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1017264011379 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1017264011380 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1017264011381 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1017264011382 Subunit III/VIIa interface [polypeptide binding]; other site 1017264011383 Phospholipid binding site [chemical binding]; other site 1017264011384 Subunit I/III interface [polypeptide binding]; other site 1017264011385 Subunit III/VIb interface [polypeptide binding]; other site 1017264011386 Subunit III/VIa interface; other site 1017264011387 Subunit III/Vb interface [polypeptide binding]; other site 1017264011388 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1017264011389 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1017264011390 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1017264011391 Subunit I/III interface [polypeptide binding]; other site 1017264011392 D-pathway; other site 1017264011393 Subunit I/VIIc interface [polypeptide binding]; other site 1017264011394 Subunit I/IV interface [polypeptide binding]; other site 1017264011395 Subunit I/II interface [polypeptide binding]; other site 1017264011396 Low-spin heme (heme a) binding site [chemical binding]; other site 1017264011397 Subunit I/VIIa interface [polypeptide binding]; other site 1017264011398 Subunit I/VIa interface [polypeptide binding]; other site 1017264011399 Dimer interface; other site 1017264011400 Putative water exit pathway; other site 1017264011401 Binuclear center (heme a3/CuB) [ion binding]; other site 1017264011402 K-pathway; other site 1017264011403 Subunit I/Vb interface [polypeptide binding]; other site 1017264011404 Putative proton exit pathway; other site 1017264011405 Subunit I/VIb interface; other site 1017264011406 Subunit I/VIc interface [polypeptide binding]; other site 1017264011407 Electron transfer pathway; other site 1017264011408 Subunit I/VIIIb interface [polypeptide binding]; other site 1017264011409 Subunit I/VIIb interface [polypeptide binding]; other site 1017264011410 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 1017264011411 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1017264011412 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1017264011413 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1017264011414 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1017264011415 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 1017264011416 nudix motif; other site 1017264011417 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1017264011418 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1017264011419 flexible hinge region; other site 1017264011420 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1017264011421 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1017264011422 active site 1017264011423 metal binding site [ion binding]; metal-binding site 1017264011424 hexamer interface [polypeptide binding]; other site 1017264011425 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1017264011426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1017264011427 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1017264011428 DNA binding residues [nucleotide binding] 1017264011429 S-formylglutathione hydrolase; Region: PLN02442 1017264011430 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1017264011431 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1017264011432 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1017264011433 substrate binding site [chemical binding]; other site 1017264011434 catalytic Zn binding site [ion binding]; other site 1017264011435 NAD binding site [chemical binding]; other site 1017264011436 structural Zn binding site [ion binding]; other site 1017264011437 dimer interface [polypeptide binding]; other site 1017264011438 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1017264011439 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1017264011440 active site 1017264011441 dimer interface [polypeptide binding]; other site 1017264011442 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1017264011443 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1017264011444 active site 1017264011445 FMN binding site [chemical binding]; other site 1017264011446 substrate binding site [chemical binding]; other site 1017264011447 3Fe-4S cluster binding site [ion binding]; other site 1017264011448 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1017264011449 domain interface; other site 1017264011450 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1017264011451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1017264011452 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 1017264011453 OmpW family; Region: OmpW; cl17427 1017264011454 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264011455 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1017264011456 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1017264011457 Walker A/P-loop; other site 1017264011458 ATP binding site [chemical binding]; other site 1017264011459 Q-loop/lid; other site 1017264011460 ABC transporter signature motif; other site 1017264011461 Walker B; other site 1017264011462 D-loop; other site 1017264011463 H-loop/switch region; other site 1017264011464 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1017264011465 Permease; Region: Permease; pfam02405 1017264011466 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1017264011467 mce related protein; Region: MCE; pfam02470 1017264011468 VacJ like lipoprotein; Region: VacJ; cl01073 1017264011469 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1017264011470 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1017264011471 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1017264011472 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1017264011473 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1017264011474 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1017264011475 hinge; other site 1017264011476 active site 1017264011477 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1017264011478 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1017264011479 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1017264011480 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1017264011481 NAD binding site [chemical binding]; other site 1017264011482 dimerization interface [polypeptide binding]; other site 1017264011483 product binding site; other site 1017264011484 substrate binding site [chemical binding]; other site 1017264011485 zinc binding site [ion binding]; other site 1017264011486 catalytic residues [active] 1017264011487 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 1017264011488 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264011489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264011490 homodimer interface [polypeptide binding]; other site 1017264011491 catalytic residue [active] 1017264011492 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1017264011493 putative active site pocket [active] 1017264011494 4-fold oligomerization interface [polypeptide binding]; other site 1017264011495 metal binding residues [ion binding]; metal-binding site 1017264011496 3-fold/trimer interface [polypeptide binding]; other site 1017264011497 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1017264011498 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1017264011499 putative active site [active] 1017264011500 oxyanion strand; other site 1017264011501 catalytic triad [active] 1017264011502 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1017264011503 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1017264011504 catalytic residues [active] 1017264011505 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1017264011506 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1017264011507 substrate binding site [chemical binding]; other site 1017264011508 glutamase interaction surface [polypeptide binding]; other site 1017264011509 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1017264011510 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1017264011511 metal binding site [ion binding]; metal-binding site 1017264011512 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1017264011513 nucleotide binding site/active site [active] 1017264011514 HIT family signature motif; other site 1017264011515 catalytic residue [active] 1017264011516 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 1017264011517 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1017264011518 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1017264011519 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264011520 Pertussis toxin, subunit 1; Region: Pertussis_S1; pfam02917 1017264011521 Aerolysin/Pertussis toxin (APT) domain; Region: APT; pfam03440 1017264011522 Pertussis toxin, subunit 2 and 3, C-terminal domain; Region: Pertussis_S2S3; pfam02918 1017264011523 Pertussis toxin S4 subunit; Region: Pertus-S4-tox; pfam09275 1017264011524 Pertussis toxin S5 subunit; Region: Pertus-S5-tox; pfam09276 1017264011525 Aerolysin/Pertussis toxin (APT) domain; Region: APT; pfam03440 1017264011526 Pertussis toxin, subunit 2 and 3, C-terminal domain; Region: Pertussis_S2S3; pfam02918 1017264011527 TrbC/VIRB2 family; Region: TrbC; pfam04956 1017264011528 Type IV secretory pathway, VirB3-like protein; Region: VirB3; pfam05101 1017264011529 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 1017264011530 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1017264011531 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1017264011532 VirB8 protein; Region: VirB8; pfam04335 1017264011533 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1017264011534 VirB7 interaction site; other site 1017264011535 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 1017264011536 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1017264011537 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1017264011538 Walker A motif; other site 1017264011539 hexamer interface [polypeptide binding]; other site 1017264011540 ATP binding site [chemical binding]; other site 1017264011541 Walker B motif; other site 1017264011542 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1017264011543 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1017264011544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1017264011545 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1017264011546 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 1017264011547 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 1017264011548 G1 box; other site 1017264011549 GTP/Mg2+ binding site [chemical binding]; other site 1017264011550 G2 box; other site 1017264011551 Switch I region; other site 1017264011552 G3 box; other site 1017264011553 Switch II region; other site 1017264011554 G4 box; other site 1017264011555 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 1017264011556 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1017264011557 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1017264011558 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1017264011559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264011560 dimer interface [polypeptide binding]; other site 1017264011561 conserved gate region; other site 1017264011562 putative PBP binding loops; other site 1017264011563 ABC-ATPase subunit interface; other site 1017264011564 dipeptide transporter; Provisional; Region: PRK10913 1017264011565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264011566 dimer interface [polypeptide binding]; other site 1017264011567 conserved gate region; other site 1017264011568 putative PBP binding loops; other site 1017264011569 ABC-ATPase subunit interface; other site 1017264011570 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264011571 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264011572 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264011573 Integrase core domain; Region: rve; pfam00665 1017264011574 Integrase core domain; Region: rve_3; pfam13683 1017264011575 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1017264011576 heterotetramer interface [polypeptide binding]; other site 1017264011577 active site pocket [active] 1017264011578 cleavage site 1017264011579 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1017264011580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1017264011581 Walker A motif; other site 1017264011582 ATP binding site [chemical binding]; other site 1017264011583 Walker B motif; other site 1017264011584 hypothetical protein; Provisional; Region: PRK08999 1017264011585 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1017264011586 active site 1017264011587 8-oxo-dGMP binding site [chemical binding]; other site 1017264011588 nudix motif; other site 1017264011589 metal binding site [ion binding]; metal-binding site 1017264011590 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1017264011591 active site 1017264011592 thiamine phosphate binding site [chemical binding]; other site 1017264011593 pyrophosphate binding site [ion binding]; other site 1017264011594 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264011595 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264011596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1017264011597 Integrase core domain; Region: rve; pfam00665 1017264011598 Integrase core domain; Region: rve_3; pfam13683 1017264011599 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264011600 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264011601 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264011602 Integrase core domain; Region: rve; pfam00665 1017264011603 Integrase core domain; Region: rve_3; pfam13683 1017264011604 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1017264011605 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1017264011606 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1017264011607 Protein export membrane protein; Region: SecD_SecF; cl14618 1017264011608 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1017264011609 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1017264011610 HlyD family secretion protein; Region: HlyD_3; pfam13437 1017264011611 hypothetical protein; Provisional; Region: PRK05287 1017264011612 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1017264011613 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1017264011614 CoA-binding site [chemical binding]; other site 1017264011615 ATP-binding [chemical binding]; other site 1017264011616 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1017264011617 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1017264011618 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1017264011619 NlpE N-terminal domain; Region: NlpE; pfam04170 1017264011620 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1017264011621 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1017264011622 DNA binding residues [nucleotide binding] 1017264011623 dimerization interface [polypeptide binding]; other site 1017264011624 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1017264011625 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1017264011626 active site 1017264011627 ATP-binding site [chemical binding]; other site 1017264011628 pantoate-binding site; other site 1017264011629 HXXH motif; other site 1017264011630 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1017264011631 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 1017264011632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1017264011633 putative substrate translocation pore; other site 1017264011634 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1017264011635 glycerol kinase; Provisional; Region: glpK; PRK00047 1017264011636 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1017264011637 N- and C-terminal domain interface [polypeptide binding]; other site 1017264011638 active site 1017264011639 MgATP binding site [chemical binding]; other site 1017264011640 catalytic site [active] 1017264011641 metal binding site [ion binding]; metal-binding site 1017264011642 glycerol binding site [chemical binding]; other site 1017264011643 homotetramer interface [polypeptide binding]; other site 1017264011644 homodimer interface [polypeptide binding]; other site 1017264011645 FBP binding site [chemical binding]; other site 1017264011646 protein IIAGlc interface [polypeptide binding]; other site 1017264011647 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1017264011648 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264011649 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1017264011650 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1017264011651 Walker A/P-loop; other site 1017264011652 ATP binding site [chemical binding]; other site 1017264011653 Q-loop/lid; other site 1017264011654 ABC transporter signature motif; other site 1017264011655 Walker B; other site 1017264011656 D-loop; other site 1017264011657 H-loop/switch region; other site 1017264011658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264011659 dimer interface [polypeptide binding]; other site 1017264011660 conserved gate region; other site 1017264011661 putative PBP binding loops; other site 1017264011662 ABC-ATPase subunit interface; other site 1017264011663 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1017264011664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1017264011665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264011666 dimer interface [polypeptide binding]; other site 1017264011667 conserved gate region; other site 1017264011668 putative PBP binding loops; other site 1017264011669 ABC-ATPase subunit interface; other site 1017264011670 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1017264011671 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1017264011672 substrate binding pocket [chemical binding]; other site 1017264011673 membrane-bound complex binding site; other site 1017264011674 hinge residues; other site 1017264011675 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1017264011676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1017264011677 Walker A/P-loop; other site 1017264011678 ATP binding site [chemical binding]; other site 1017264011679 Q-loop/lid; other site 1017264011680 ABC transporter signature motif; other site 1017264011681 Walker B; other site 1017264011682 D-loop; other site 1017264011683 H-loop/switch region; other site 1017264011684 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1017264011685 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 1017264011686 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1017264011687 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1017264011688 minor groove reading motif; other site 1017264011689 helix-hairpin-helix signature motif; other site 1017264011690 substrate binding pocket [chemical binding]; other site 1017264011691 active site 1017264011692 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1017264011693 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1017264011694 DNA binding and oxoG recognition site [nucleotide binding] 1017264011695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1017264011696 salt bridge; other site 1017264011697 non-specific DNA binding site [nucleotide binding]; other site 1017264011698 sequence-specific DNA binding site [nucleotide binding]; other site 1017264011699 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1017264011700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1017264011701 S-adenosylmethionine binding site [chemical binding]; other site 1017264011702 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264011703 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264011704 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264011705 Integrase core domain; Region: rve; pfam00665 1017264011706 Integrase core domain; Region: rve_3; pfam13683 1017264011707 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264011708 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264011709 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1017264011710 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1017264011711 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1017264011712 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264011713 substrate binding site [chemical binding]; other site 1017264011714 oxyanion hole (OAH) forming residues; other site 1017264011715 trimer interface [polypeptide binding]; other site 1017264011716 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1017264011717 putative FMN binding site [chemical binding]; other site 1017264011718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1017264011719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1017264011720 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1017264011721 active site 1017264011722 catalytic residues [active] 1017264011723 metal binding site [ion binding]; metal-binding site 1017264011724 enoyl-CoA hydratase; Provisional; Region: PRK08252 1017264011725 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1017264011726 substrate binding site [chemical binding]; other site 1017264011727 oxyanion hole (OAH) forming residues; other site 1017264011728 trimer interface [polypeptide binding]; other site 1017264011729 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1017264011730 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1017264011731 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1017264011732 Winged helix-turn helix; Region: HTH_29; pfam13551 1017264011733 Helix-turn-helix domain; Region: HTH_38; pfam13936 1017264011734 Integrase core domain; Region: rve; pfam00665 1017264011735 Integrase core domain; Region: rve_3; pfam13683 1017264011736 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1017264011737 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1017264011738 tetramer interface [polypeptide binding]; other site 1017264011739 heme binding pocket [chemical binding]; other site 1017264011740 NADPH binding site [chemical binding]; other site 1017264011741 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1017264011742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264011743 putative PBP binding loops; other site 1017264011744 ABC-ATPase subunit interface; other site 1017264011745 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1017264011746 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1017264011747 Walker A/P-loop; other site 1017264011748 ATP binding site [chemical binding]; other site 1017264011749 Q-loop/lid; other site 1017264011750 ABC transporter signature motif; other site 1017264011751 Walker B; other site 1017264011752 D-loop; other site 1017264011753 H-loop/switch region; other site 1017264011754 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1017264011755 NMT1-like family; Region: NMT1_2; pfam13379 1017264011756 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1017264011757 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1017264011758 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1017264011759 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1017264011760 metal binding site [ion binding]; metal-binding site 1017264011761 putative dimer interface [polypeptide binding]; other site 1017264011762 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 1017264011763 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264011764 Walker A/P-loop; other site 1017264011765 ATP binding site [chemical binding]; other site 1017264011766 Q-loop/lid; other site 1017264011767 ABC transporter signature motif; other site 1017264011768 Walker B; other site 1017264011769 D-loop; other site 1017264011770 H-loop/switch region; other site 1017264011771 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1017264011772 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1017264011773 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1017264011774 Walker A/P-loop; other site 1017264011775 ATP binding site [chemical binding]; other site 1017264011776 Q-loop/lid; other site 1017264011777 ABC transporter signature motif; other site 1017264011778 Walker B; other site 1017264011779 D-loop; other site 1017264011780 H-loop/switch region; other site 1017264011781 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1017264011782 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1017264011783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264011784 dimer interface [polypeptide binding]; other site 1017264011785 conserved gate region; other site 1017264011786 putative PBP binding loops; other site 1017264011787 ABC-ATPase subunit interface; other site 1017264011788 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1017264011789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1017264011790 dimer interface [polypeptide binding]; other site 1017264011791 conserved gate region; other site 1017264011792 ABC-ATPase subunit interface; other site 1017264011793 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1017264011794 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1017264011795 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1017264011796 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1017264011797 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1017264011798 G1 box; other site 1017264011799 GTP/Mg2+ binding site [chemical binding]; other site 1017264011800 Switch I region; other site 1017264011801 G2 box; other site 1017264011802 Switch II region; other site 1017264011803 G3 box; other site 1017264011804 G4 box; other site 1017264011805 G5 box; other site 1017264011806 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1017264011807 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1017264011808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1017264011809 active site 1017264011810 phosphorylation site [posttranslational modification] 1017264011811 intermolecular recognition site; other site 1017264011812 dimerization interface [polypeptide binding]; other site 1017264011813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1017264011814 DNA binding site [nucleotide binding] 1017264011815 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1017264011816 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1017264011817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1017264011818 dimer interface [polypeptide binding]; other site 1017264011819 phosphorylation site [posttranslational modification] 1017264011820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1017264011821 ATP binding site [chemical binding]; other site 1017264011822 Mg2+ binding site [ion binding]; other site 1017264011823 G-X-G motif; other site 1017264011824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1017264011825 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1017264011826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1017264011827 methionine aminotransferase; Validated; Region: PRK09082 1017264011828 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1017264011829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1017264011830 homodimer interface [polypeptide binding]; other site 1017264011831 catalytic residue [active] 1017264011832 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1017264011833 DNA-binding site [nucleotide binding]; DNA binding site 1017264011834 RNA-binding motif; other site