-- dump date 20140619_004839 -- class Genbank::misc_feature -- table misc_feature_note -- id note 412418000001 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418000002 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418000003 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418000004 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 412418000005 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 412418000006 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 412418000007 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412418000008 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 412418000009 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 412418000010 active site 412418000011 substrate binding site [chemical binding]; other site 412418000012 metal binding site [ion binding]; metal-binding site 412418000013 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 412418000014 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 412418000015 active site 412418000016 HIGH motif; other site 412418000017 dimer interface [polypeptide binding]; other site 412418000018 KMSKS motif; other site 412418000019 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 412418000020 Domain of unknown function DUF20; Region: UPF0118; pfam01594 412418000021 TIGR00159 family protein; Region: TIGR00159 412418000022 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 412418000023 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 412418000024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 412418000025 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 412418000026 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 412418000027 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 412418000028 dimerization interface 3.5A [polypeptide binding]; other site 412418000029 active site 412418000030 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 412418000031 primosomal protein N' Region: priA; TIGR00595 412418000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412418000033 ATP binding site [chemical binding]; other site 412418000034 putative Mg++ binding site [ion binding]; other site 412418000035 Trm112p-like protein; Region: Trm112p; cl01066 412418000036 helicase superfamily c-terminal domain; Region: HELICc; smart00490 412418000037 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 412418000038 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 412418000039 ATP-binding site [chemical binding]; other site 412418000040 Sugar specificity; other site 412418000041 Pyrimidine base specificity; other site 412418000042 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412418000043 active site residue [active] 412418000044 Uncharacterized conserved protein [Function unknown]; Region: COG1284 412418000045 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412418000046 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 412418000047 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 412418000048 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 412418000049 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 412418000050 active site 412418000051 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 412418000052 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 412418000053 active site 412418000054 ADP/pyrophosphate binding site [chemical binding]; other site 412418000055 dimerization interface [polypeptide binding]; other site 412418000056 allosteric effector site; other site 412418000057 fructose-1,6-bisphosphate binding site; other site 412418000058 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 412418000059 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 412418000060 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 412418000061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412418000062 Walker A motif; other site 412418000063 ATP binding site [chemical binding]; other site 412418000064 Walker B motif; other site 412418000065 arginine finger; other site 412418000066 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 412418000067 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK13901 412418000068 RuvA N terminal domain; Region: RuvA_N; pfam01330 412418000069 hypothetical protein; Validated; Region: PRK00110 412418000070 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 412418000071 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 412418000072 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 412418000073 homodimer interface [polypeptide binding]; other site 412418000074 NADP binding site [chemical binding]; other site 412418000075 substrate binding site [chemical binding]; other site 412418000076 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 412418000077 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 412418000078 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412418000079 Catalytic site [active] 412418000080 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412418000081 PEGA domain; Region: PEGA; pfam08308 412418000082 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 412418000083 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 412418000084 SmpB-tmRNA interface; other site 412418000085 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 412418000086 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 412418000087 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 412418000088 CAP-like domain; other site 412418000089 active site 412418000090 primary dimer interface [polypeptide binding]; other site 412418000091 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 412418000092 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 412418000093 ATP binding site [chemical binding]; other site 412418000094 Mg2+ binding site [ion binding]; other site 412418000095 G-X-G motif; other site 412418000096 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 412418000097 anchoring element; other site 412418000098 dimer interface [polypeptide binding]; other site 412418000099 ATP binding site [chemical binding]; other site 412418000100 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 412418000101 active site 412418000102 putative metal-binding site [ion binding]; other site 412418000103 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 412418000104 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 412418000105 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 412418000106 putative acyl-acceptor binding pocket; other site 412418000107 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 412418000108 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 412418000109 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 412418000110 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 412418000111 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 412418000112 PhoU domain; Region: PhoU; pfam01895 412418000113 PhoU domain; Region: PhoU; pfam01895 412418000114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418000115 AAA domain; Region: AAA_23; pfam13476 412418000116 Walker A/P-loop; other site 412418000117 ATP binding site [chemical binding]; other site 412418000118 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 412418000119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418000120 ABC transporter signature motif; other site 412418000121 Walker B; other site 412418000122 D-loop; other site 412418000123 H-loop/switch region; other site 412418000124 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 412418000125 RNA/DNA hybrid binding site [nucleotide binding]; other site 412418000126 active site 412418000127 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 412418000128 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 412418000129 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 412418000130 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 412418000131 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 412418000132 ligand binding site [chemical binding]; other site 412418000133 active site 412418000134 UGI interface [polypeptide binding]; other site 412418000135 catalytic site [active] 412418000136 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 412418000137 triosephosphate isomerase; Provisional; Region: PRK14565 412418000138 substrate binding site [chemical binding]; other site 412418000139 dimer interface [polypeptide binding]; other site 412418000140 catalytic triad [active] 412418000141 Phosphoglycerate kinase; Region: PGK; pfam00162 412418000142 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 412418000143 substrate binding site [chemical binding]; other site 412418000144 hinge regions; other site 412418000145 ADP binding site [chemical binding]; other site 412418000146 catalytic site [active] 412418000147 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 412418000148 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 412418000149 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 412418000150 TPR repeat; Region: TPR_11; pfam13414 412418000151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000152 binding surface 412418000153 TPR motif; other site 412418000154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000155 TPR motif; other site 412418000156 binding surface 412418000157 FOG: CBS domain [General function prediction only]; Region: COG0517 412418000158 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412418000159 Transporter associated domain; Region: CorC_HlyC; smart01091 412418000160 metal-binding heat shock protein; Provisional; Region: PRK00016 412418000161 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412418000162 catalytic residues [active] 412418000163 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 412418000164 RNA methyltransferase, RsmE family; Region: TIGR00046 412418000165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 412418000166 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 412418000167 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 412418000168 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 412418000169 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 412418000170 putative active site [active] 412418000171 substrate binding site [chemical binding]; other site 412418000172 putative cosubstrate binding site; other site 412418000173 catalytic site [active] 412418000174 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 412418000175 substrate binding site [chemical binding]; other site 412418000176 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 412418000177 active site 412418000178 catalytic residues [active] 412418000179 metal binding site [ion binding]; metal-binding site 412418000180 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412418000181 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 412418000182 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 412418000183 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 412418000184 active site 412418000185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412418000186 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 412418000187 active site 412418000188 motif I; other site 412418000189 motif II; other site 412418000190 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 412418000191 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 412418000192 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 412418000193 Divergent PAP2 family; Region: DUF212; pfam02681 412418000194 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 412418000195 peptide chain release factor 2; Validated; Region: prfB; PRK00578 412418000196 This domain is found in peptide chain release factors; Region: PCRF; smart00937 412418000197 RF-1 domain; Region: RF-1; pfam00472 412418000198 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 412418000199 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 412418000200 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 412418000201 DNA polymerase III PolC; Validated; Region: polC; PRK00448 412418000202 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 412418000203 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 412418000204 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 412418000205 Walker A/P-loop; other site 412418000206 ATP binding site [chemical binding]; other site 412418000207 Q-loop/lid; other site 412418000208 ABC transporter signature motif; other site 412418000209 Walker B; other site 412418000210 D-loop; other site 412418000211 H-loop/switch region; other site 412418000212 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 412418000213 FtsX-like permease family; Region: FtsX; pfam02687 412418000214 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 412418000215 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 412418000216 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412418000217 catalytic residue [active] 412418000218 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 412418000219 active site 412418000220 trimerization site [polypeptide binding]; other site 412418000221 Mg chelatase-related protein; Region: TIGR00368 412418000222 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 412418000223 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 412418000224 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 412418000225 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 412418000226 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 412418000227 dimer interface [polypeptide binding]; other site 412418000228 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412418000229 NAD binding site [chemical binding]; other site 412418000230 substrate binding site [chemical binding]; other site 412418000231 GTP-binding protein LepA; Provisional; Region: PRK05433 412418000232 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 412418000233 Switch I region; other site 412418000234 G2 box; other site 412418000235 putative GEF interaction site [polypeptide binding]; other site 412418000236 G3 box; other site 412418000237 Switch II region; other site 412418000238 GTP/Mg2+ binding site [chemical binding]; other site 412418000239 G4 box; other site 412418000240 G5 box; other site 412418000241 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 412418000242 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 412418000243 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 412418000244 V-type ATP synthase subunit K; Validated; Region: PRK06649 412418000245 ATP synthase subunit C; Region: ATP-synt_C; cl00466 412418000246 V-type ATP synthase subunit I; Validated; Region: PRK05771 412418000247 V-type ATP synthase subunit D; Provisional; Region: PRK02195 412418000248 V-type ATP synthase subunit B; Provisional; Region: PRK02118 412418000249 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 412418000250 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 412418000251 Walker A motif homologous position; other site 412418000252 Walker B motif; other site 412418000253 V-type ATP synthase subunit A; Provisional; Region: PRK04192 412418000254 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 412418000255 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 412418000256 Walker A motif/ATP binding site; other site 412418000257 Walker B motif; other site 412418000258 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 412418000259 V-type ATP synthase subunit E; Provisional; Region: PRK01558 412418000260 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 412418000261 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 412418000262 RNA binding site [nucleotide binding]; other site 412418000263 ribosome small subunit-dependent GTPase A; Region: TIGR00157 412418000264 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 412418000265 GTPase/Zn-binding domain interface [polypeptide binding]; other site 412418000266 GTP/Mg2+ binding site [chemical binding]; other site 412418000267 G4 box; other site 412418000268 G5 box; other site 412418000269 G1 box; other site 412418000270 Switch I region; other site 412418000271 G2 box; other site 412418000272 G3 box; other site 412418000273 Switch II region; other site 412418000274 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 412418000275 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 412418000276 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 412418000277 putative dimer interface [polypeptide binding]; other site 412418000278 putative anticodon binding site; other site 412418000279 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 412418000280 homodimer interface [polypeptide binding]; other site 412418000281 motif 1; other site 412418000282 motif 2; other site 412418000283 active site 412418000284 motif 3; other site 412418000285 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 412418000286 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412418000287 active site 412418000288 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 412418000289 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 412418000290 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 412418000291 protein binding site [polypeptide binding]; other site 412418000292 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 412418000293 protein binding site [polypeptide binding]; other site 412418000294 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 412418000295 active site 412418000296 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 412418000297 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 412418000298 putative RNA binding site [nucleotide binding]; other site 412418000299 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 412418000300 SurA N-terminal domain; Region: SurA_N; pfam09312 412418000301 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 412418000302 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 412418000303 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 412418000304 dimer interface [polypeptide binding]; other site 412418000305 active site 412418000306 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 412418000307 replicative DNA helicase; Region: DnaB; TIGR00665 412418000308 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 412418000309 Walker A motif; other site 412418000310 ATP binding site [chemical binding]; other site 412418000311 Walker B motif; other site 412418000312 DNA binding loops [nucleotide binding] 412418000313 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 412418000314 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 412418000315 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 412418000316 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 412418000317 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 412418000318 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 412418000319 dimer interface [polypeptide binding]; other site 412418000320 ssDNA binding site [nucleotide binding]; other site 412418000321 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412418000322 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 412418000323 RIP metalloprotease RseP; Region: TIGR00054 412418000324 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 412418000325 active site 412418000326 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 412418000327 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 412418000328 protein binding site [polypeptide binding]; other site 412418000329 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 412418000330 putative substrate binding region [chemical binding]; other site 412418000331 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 412418000332 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 412418000333 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14837 412418000334 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 412418000335 catalytic residue [active] 412418000336 putative FPP diphosphate binding site; other site 412418000337 putative FPP binding hydrophobic cleft; other site 412418000338 dimer interface [polypeptide binding]; other site 412418000339 putative IPP diphosphate binding site; other site 412418000340 ribosome recycling factor; Reviewed; Region: frr; PRK00083 412418000341 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 412418000342 hinge region; other site 412418000343 elongation factor Ts; Provisional; Region: tsf; PRK09377 412418000344 Elongation factor TS; Region: EF_TS; pfam00889 412418000345 Elongation factor TS; Region: EF_TS; pfam00889 412418000346 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 412418000347 rRNA interaction site [nucleotide binding]; other site 412418000348 S8 interaction site; other site 412418000349 putative laminin-1 binding site; other site 412418000350 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 412418000351 Maf-like protein; Region: Maf; pfam02545 412418000352 putative active site [active] 412418000353 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 412418000354 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 412418000355 RNA binding site [nucleotide binding]; other site 412418000356 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 412418000357 RNA binding site [nucleotide binding]; other site 412418000358 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 412418000359 RNA binding site [nucleotide binding]; other site 412418000360 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 412418000361 RNA binding site [nucleotide binding]; other site 412418000362 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 412418000363 RNA binding site [nucleotide binding]; other site 412418000364 cytidylate kinase; Region: cmk; TIGR00017 412418000365 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 412418000366 CMP-binding site; other site 412418000367 The sites determining sugar specificity; other site 412418000368 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 412418000369 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412418000370 RNA binding surface [nucleotide binding]; other site 412418000371 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 412418000372 active site 412418000373 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 412418000374 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 412418000375 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 412418000376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000377 TPR motif; other site 412418000378 binding surface 412418000379 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412418000380 TPR repeat; Region: TPR_11; pfam13414 412418000381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000382 binding surface 412418000383 TPR motif; other site 412418000384 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 412418000385 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 412418000386 dimer interface [polypeptide binding]; other site 412418000387 motif 1; other site 412418000388 active site 412418000389 motif 2; other site 412418000390 motif 3; other site 412418000391 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 412418000392 anticodon binding site; other site 412418000393 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 412418000394 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412418000395 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412418000396 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 412418000397 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 412418000398 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412418000399 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 412418000400 acyl-activating enzyme (AAE) consensus motif; other site 412418000401 acyl-activating enzyme (AAE) consensus motif; other site 412418000402 putative AMP binding site [chemical binding]; other site 412418000403 putative active site [active] 412418000404 putative CoA binding site [chemical binding]; other site 412418000405 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 412418000406 Protein export membrane protein; Region: SecD_SecF; cl14618 412418000407 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 412418000408 carboxyltransferase (CT) interaction site; other site 412418000409 biotinylation site [posttranslational modification]; other site 412418000410 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 412418000411 HlyD family secretion protein; Region: HlyD_3; pfam13437 412418000412 Outer membrane efflux protein; Region: OEP; pfam02321 412418000413 Outer membrane efflux protein; Region: OEP; pfam02321 412418000414 hypothetical protein; Provisional; Region: PRK14385 412418000415 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 412418000416 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 412418000417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412418000418 dimer interface [polypeptide binding]; other site 412418000419 conserved gate region; other site 412418000420 ABC-ATPase subunit interface; other site 412418000421 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 412418000422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418000423 Walker A/P-loop; other site 412418000424 ATP binding site [chemical binding]; other site 412418000425 Q-loop/lid; other site 412418000426 ABC transporter signature motif; other site 412418000427 Walker B; other site 412418000428 D-loop; other site 412418000429 H-loop/switch region; other site 412418000430 flagellin; Provisional; Region: PRK12803 412418000431 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 412418000432 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 412418000433 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 412418000434 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 412418000435 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 412418000436 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 412418000437 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 412418000438 active site 412418000439 dimer interface [polypeptide binding]; other site 412418000440 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 412418000441 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 412418000442 active site 412418000443 trimer interface [polypeptide binding]; other site 412418000444 allosteric site; other site 412418000445 active site lid [active] 412418000446 hexamer (dimer of trimers) interface [polypeptide binding]; other site 412418000447 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 412418000448 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 412418000449 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 412418000450 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 412418000451 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 412418000452 SEC-C motif; Region: SEC-C; pfam02810 412418000453 alanine racemase; Region: alr; TIGR00492 412418000454 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 412418000455 active site 412418000456 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412418000457 dimer interface [polypeptide binding]; other site 412418000458 substrate binding site [chemical binding]; other site 412418000459 catalytic residues [active] 412418000460 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 412418000461 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 412418000462 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 412418000463 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 412418000464 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 412418000465 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412418000466 ligand binding site [chemical binding]; other site 412418000467 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 412418000468 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 412418000469 rRNA binding site [nucleotide binding]; other site 412418000470 predicted 30S ribosome binding site; other site 412418000471 Oxygen tolerance; Region: BatD; pfam13584 412418000472 Bacterial SH3 domain homologues; Region: SH3b; smart00287 412418000473 TPR repeat; Region: TPR_11; pfam13414 412418000474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000475 binding surface 412418000476 TPR motif; other site 412418000477 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412418000478 von Willebrand factor type A domain; Region: VWA_2; pfam13519 412418000479 metal ion-dependent adhesion site (MIDAS); other site 412418000480 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 412418000481 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 412418000482 metal ion-dependent adhesion site (MIDAS); other site 412418000483 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 412418000484 Protein of unknown function DUF58; Region: DUF58; pfam01882 412418000485 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 412418000486 MoxR-like ATPases [General function prediction only]; Region: COG0714 412418000487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412418000488 Walker A motif; other site 412418000489 ATP binding site [chemical binding]; other site 412418000490 Walker B motif; other site 412418000491 arginine finger; other site 412418000492 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 412418000493 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 412418000494 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 412418000495 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 412418000496 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 412418000497 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 412418000498 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 412418000499 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 412418000500 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 412418000501 GTP/Mg2+ binding site [chemical binding]; other site 412418000502 G4 box; other site 412418000503 G5 box; other site 412418000504 trmE is a tRNA modification GTPase; Region: trmE; cd04164 412418000505 G1 box; other site 412418000506 G1 box; other site 412418000507 GTP/Mg2+ binding site [chemical binding]; other site 412418000508 Switch I region; other site 412418000509 Switch I region; other site 412418000510 G2 box; other site 412418000511 G2 box; other site 412418000512 Switch II region; other site 412418000513 G3 box; other site 412418000514 G4 box; other site 412418000515 G5 box; other site 412418000516 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 412418000517 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 412418000518 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 412418000519 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 412418000520 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 412418000521 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 412418000522 flagellar assembly protein FliW; Provisional; Region: PRK13285 412418000523 carbon storage regulator (csrA); Region: csrA; TIGR00202 412418000524 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 412418000525 Glycoprotease family; Region: Peptidase_M22; pfam00814 412418000526 tRNA threonylcarbamoyl adenosine modification protein YjeE; Region: T6A_YjeE; TIGR00150 412418000527 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 412418000528 23S rRNA binding site [nucleotide binding]; other site 412418000529 L21 binding site [polypeptide binding]; other site 412418000530 L13 binding site [polypeptide binding]; other site 412418000531 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 412418000532 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 412418000533 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 412418000534 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 412418000535 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 412418000536 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 412418000537 active site 412418000538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000539 binding surface 412418000540 TPR motif; other site 412418000541 TPR repeat; Region: TPR_11; pfam13414 412418000542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000543 binding surface 412418000544 TPR motif; other site 412418000545 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 412418000546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000547 binding surface 412418000548 TPR motif; other site 412418000549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000550 binding surface 412418000551 TPR motif; other site 412418000552 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412418000553 peptide chain release factor 1; Validated; Region: prfA; PRK00591 412418000554 PCRF domain; Region: PCRF; pfam03462 412418000555 RF-1 domain; Region: RF-1; pfam00472 412418000556 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 412418000557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412418000558 S-adenosylmethionine binding site [chemical binding]; other site 412418000559 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 412418000560 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412418000561 Zn2+ binding site [ion binding]; other site 412418000562 Mg2+ binding site [ion binding]; other site 412418000563 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 412418000564 synthetase active site [active] 412418000565 NTP binding site [chemical binding]; other site 412418000566 metal binding site [ion binding]; metal-binding site 412418000567 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 412418000568 D-alanyl-alanine synthetase A; Provisional; Region: PRK14570 412418000569 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 412418000570 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 412418000571 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 412418000572 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412418000573 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412418000574 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412418000575 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 412418000576 Domain of unknown function DUF21; Region: DUF21; pfam01595 412418000577 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412418000578 Transporter associated domain; Region: CorC_HlyC; smart01091 412418000579 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 412418000580 HflK protein; Region: hflK; TIGR01933 412418000581 HflC protein; Region: hflC; TIGR01932 412418000582 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 412418000583 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 412418000584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412418000585 S-adenosylmethionine binding site [chemical binding]; other site 412418000586 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 412418000587 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 412418000588 active site 412418000589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000590 binding surface 412418000591 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412418000592 TPR motif; other site 412418000593 TPR repeat; Region: TPR_11; pfam13414 412418000594 TPR repeat; Region: TPR_11; pfam13414 412418000595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000596 binding surface 412418000597 TPR motif; other site 412418000598 TPR repeat; Region: TPR_11; pfam13414 412418000599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000600 binding surface 412418000601 TPR motif; other site 412418000602 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412418000603 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412418000604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000605 binding surface 412418000606 TPR motif; other site 412418000607 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412418000608 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 412418000609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412418000610 ATP binding site [chemical binding]; other site 412418000611 Mg2+ binding site [ion binding]; other site 412418000612 G-X-G motif; other site 412418000613 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 412418000614 ATP binding site [chemical binding]; other site 412418000615 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 412418000616 elongation factor P; Validated; Region: PRK00529 412418000617 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 412418000618 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 412418000619 RNA binding site [nucleotide binding]; other site 412418000620 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 412418000621 RNA binding site [nucleotide binding]; other site 412418000622 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 412418000623 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 412418000624 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 412418000625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412418000626 dimer interface [polypeptide binding]; other site 412418000627 conserved gate region; other site 412418000628 putative PBP binding loops; other site 412418000629 ABC-ATPase subunit interface; other site 412418000630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 412418000631 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 412418000632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412418000633 ABC-ATPase subunit interface; other site 412418000634 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 412418000635 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 412418000636 Walker A/P-loop; other site 412418000637 ATP binding site [chemical binding]; other site 412418000638 Q-loop/lid; other site 412418000639 ABC transporter signature motif; other site 412418000640 Walker B; other site 412418000641 D-loop; other site 412418000642 H-loop/switch region; other site 412418000643 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 412418000644 ZIP Zinc transporter; Region: Zip; pfam02535 412418000645 alanyl-tRNA synthetase; Provisional; Region: PRK01584 412418000646 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 412418000647 motif 1; other site 412418000648 active site 412418000649 motif 2; other site 412418000650 motif 3; other site 412418000651 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 412418000652 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 412418000653 FliG C-terminal domain; Region: FliG_C; pfam01706 412418000654 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 412418000655 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 412418000656 putative active site [active] 412418000657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 412418000658 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 412418000659 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 412418000660 FMN binding site [chemical binding]; other site 412418000661 active site 412418000662 catalytic residues [active] 412418000663 substrate binding site [chemical binding]; other site 412418000664 seryl-tRNA synthetase; Provisional; Region: PRK05431 412418000665 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 412418000666 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 412418000667 dimer interface [polypeptide binding]; other site 412418000668 active site 412418000669 motif 1; other site 412418000670 motif 2; other site 412418000671 motif 3; other site 412418000672 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 412418000673 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 412418000674 Peptidase M16C associated; Region: M16C_assoc; pfam08367 412418000675 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 412418000676 transcription termination factor Rho; Provisional; Region: rho; PRK09376 412418000677 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 412418000678 RNA binding site [nucleotide binding]; other site 412418000679 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 412418000680 multimer interface [polypeptide binding]; other site 412418000681 Walker A motif; other site 412418000682 ATP binding site [chemical binding]; other site 412418000683 Walker B motif; other site 412418000684 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 412418000685 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 412418000686 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412418000687 IHF dimer interface [polypeptide binding]; other site 412418000688 IHF - DNA interface [nucleotide binding]; other site 412418000689 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 412418000690 GTP-binding protein YchF; Reviewed; Region: PRK09601 412418000691 YchF GTPase; Region: YchF; cd01900 412418000692 G1 box; other site 412418000693 GTP/Mg2+ binding site [chemical binding]; other site 412418000694 Switch I region; other site 412418000695 G2 box; other site 412418000696 Switch II region; other site 412418000697 G3 box; other site 412418000698 G4 box; other site 412418000699 G5 box; other site 412418000700 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 412418000701 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412418000702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000703 TPR motif; other site 412418000704 binding surface 412418000705 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 412418000706 von Willebrand factor type A domain; Region: VWA_2; pfam13519 412418000707 metal ion-dependent adhesion site (MIDAS); other site 412418000708 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 412418000709 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 412418000710 putative active site [active] 412418000711 catalytic triad [active] 412418000712 putative dimer interface [polypeptide binding]; other site 412418000713 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 412418000714 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 412418000715 Substrate-binding site [chemical binding]; other site 412418000716 Substrate specificity [chemical binding]; other site 412418000717 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 412418000718 amphipathic channel; other site 412418000719 Asn-Pro-Ala signature motifs; other site 412418000720 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 412418000721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412418000722 putative substrate translocation pore; other site 412418000723 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 412418000724 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 412418000725 active site 412418000726 catalytic site [active] 412418000727 metal binding site [ion binding]; metal-binding site 412418000728 Protein of unknown function (DUF327); Region: DUF327; cl00753 412418000729 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 412418000730 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 412418000731 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412418000732 Peptidase family M23; Region: Peptidase_M23; pfam01551 412418000733 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 412418000734 active site 412418000735 dimerization interface [polypeptide binding]; other site 412418000736 oligoendopeptidase F; Region: pepF; TIGR00181 412418000737 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 412418000738 active site 412418000739 Zn binding site [ion binding]; other site 412418000740 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 412418000741 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 412418000742 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 412418000743 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 412418000744 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 412418000745 HIGH motif; other site 412418000746 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412418000747 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412418000748 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412418000749 active site 412418000750 KMSKS motif; other site 412418000751 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 412418000752 tRNA binding surface [nucleotide binding]; other site 412418000753 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 412418000754 ATP-dependent protease La; Region: lon; TIGR00763 412418000755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412418000756 Walker A motif; other site 412418000757 ATP binding site [chemical binding]; other site 412418000758 Walker B motif; other site 412418000759 arginine finger; other site 412418000760 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 412418000761 DHH family; Region: DHH; pfam01368 412418000762 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 412418000763 DHHA1 domain; Region: DHHA1; pfam02272 412418000764 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412418000765 Peptidase family M23; Region: Peptidase_M23; pfam01551 412418000766 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 412418000767 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 412418000768 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 412418000769 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 412418000770 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412418000771 Peptidase family M23; Region: Peptidase_M23; pfam01551 412418000772 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 412418000773 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 412418000774 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 412418000775 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 412418000776 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 412418000777 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 412418000778 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 412418000779 N-acetyl-D-glucosamine binding site [chemical binding]; other site 412418000780 catalytic residue [active] 412418000781 TPR repeat; Region: TPR_11; pfam13414 412418000782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000783 TPR motif; other site 412418000784 binding surface 412418000785 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412418000786 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412418000787 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412418000788 Peptidase family M23; Region: Peptidase_M23; pfam01551 412418000789 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 412418000790 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412418000791 Catalytic site [active] 412418000792 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 412418000793 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 412418000794 nucleotide binding site [chemical binding]; other site 412418000795 putative NEF/HSP70 interaction site [polypeptide binding]; other site 412418000796 SBD interface [polypeptide binding]; other site 412418000797 Uncharacterized conserved protein [Function unknown]; Region: COG1315 412418000798 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 412418000799 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 412418000800 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 412418000801 Protein of unknown function, DUF258; Region: DUF258; pfam03193 412418000802 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 412418000803 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 412418000804 FHIPEP family; Region: FHIPEP; pfam00771 412418000805 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 412418000806 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 412418000807 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 412418000808 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 412418000809 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 412418000810 flagellar biosynthesis protein FliZ; Provisional; Region: PRK13414 412418000811 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 412418000812 Flagellar motor switch protein FliM; Region: FliM; pfam02154 412418000813 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 412418000814 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK06654 412418000815 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 412418000816 flagellar motor protein MotB; Validated; Region: motB; PRK06667 412418000817 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412418000818 ligand binding site [chemical binding]; other site 412418000819 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 412418000820 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 412418000821 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 412418000822 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 412418000823 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 412418000824 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 412418000825 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 412418000826 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 412418000827 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 412418000828 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 412418000829 ATPase FliI/YscN family; Region: fliI_yscN; TIGR01026 412418000830 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 412418000831 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 412418000832 Walker A motif; other site 412418000833 ATP binding site [chemical binding]; other site 412418000834 Walker B motif; other site 412418000835 flagellar assembly protein H; Validated; Region: fliH; PRK06669 412418000836 Flagellar assembly protein FliH; Region: FliH; pfam02108 412418000837 flagellar motor switch protein FliG; Region: fliG; TIGR00207 412418000838 FliG C-terminal domain; Region: FliG_C; pfam01706 412418000839 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 412418000840 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 412418000841 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 412418000842 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01482 412418000843 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 412418000844 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 412418000845 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 412418000846 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12622 412418000847 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 412418000848 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 412418000849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412418000850 Walker A motif; other site 412418000851 ATP binding site [chemical binding]; other site 412418000852 UPF0278 family; Region: UPF0278; cl17319 412418000853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 412418000854 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 412418000855 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 412418000856 active site 412418000857 HslU subunit interaction site [polypeptide binding]; other site 412418000858 TPR repeat; Region: TPR_11; pfam13414 412418000859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000860 TPR motif; other site 412418000861 binding surface 412418000862 cell division protein FtsZ; Validated; Region: PRK09330 412418000863 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 412418000864 nucleotide binding site [chemical binding]; other site 412418000865 SulA interaction site; other site 412418000866 cell division protein FtsA; Region: ftsA; TIGR01174 412418000867 Cell division protein FtsA; Region: FtsA; smart00842 412418000868 Cell division protein FtsA; Region: FtsA; pfam14450 412418000869 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 412418000870 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 412418000871 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 412418000872 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 412418000873 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 412418000874 Mg++ binding site [ion binding]; other site 412418000875 putative catalytic motif [active] 412418000876 putative substrate binding site [chemical binding]; other site 412418000877 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412418000878 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 412418000879 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412418000880 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 412418000881 MraW methylase family; Region: Methyltransf_5; cl17771 412418000882 DNA repair protein RecN; Region: recN; TIGR00634 412418000883 ATP-NAD kinase; Region: NAD_kinase; pfam01513 412418000884 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 412418000885 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 412418000886 putative CheA interaction surface; other site 412418000887 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 412418000888 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 412418000889 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 412418000890 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 412418000891 substrate binding pocket [chemical binding]; other site 412418000892 chain length determination region; other site 412418000893 substrate-Mg2+ binding site; other site 412418000894 catalytic residues [active] 412418000895 aspartate-rich region 1; other site 412418000896 active site lid residues [active] 412418000897 aspartate-rich region 2; other site 412418000898 Uncharacterized ABC-type transport system, permease component [General function prediction only]; Region: COG1079 412418000899 TM-ABC transporter signature motif; other site 412418000900 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412418000901 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 412418000902 TM-ABC transporter signature motif; other site 412418000903 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 412418000904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418000905 Walker A/P-loop; other site 412418000906 ATP binding site [chemical binding]; other site 412418000907 Q-loop/lid; other site 412418000908 ABC transporter signature motif; other site 412418000909 Walker B; other site 412418000910 D-loop; other site 412418000911 H-loop/switch region; other site 412418000912 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418000913 ABC transporter signature motif; other site 412418000914 Walker B; other site 412418000915 D-loop; other site 412418000916 H-loop/switch region; other site 412418000917 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 412418000918 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 412418000919 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 412418000920 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 412418000921 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 412418000922 metal ion-dependent adhesion site (MIDAS); other site 412418000923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418000924 binding surface 412418000925 TPR motif; other site 412418000926 Phosphate acyltransferases; Region: PlsC; smart00563 412418000927 putative acyl-acceptor binding pocket; other site 412418000928 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 412418000929 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 412418000930 peptide binding site [polypeptide binding]; other site 412418000931 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 412418000932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412418000933 dimer interface [polypeptide binding]; other site 412418000934 conserved gate region; other site 412418000935 putative PBP binding loops; other site 412418000936 ABC-ATPase subunit interface; other site 412418000937 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 412418000938 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 412418000939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412418000940 dimer interface [polypeptide binding]; other site 412418000941 conserved gate region; other site 412418000942 putative PBP binding loops; other site 412418000943 ABC-ATPase subunit interface; other site 412418000944 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412418000945 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 412418000946 Walker A/P-loop; other site 412418000947 ATP binding site [chemical binding]; other site 412418000948 Q-loop/lid; other site 412418000949 ABC transporter signature motif; other site 412418000950 Walker B; other site 412418000951 D-loop; other site 412418000952 H-loop/switch region; other site 412418000953 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 412418000954 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 412418000955 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 412418000956 Walker A/P-loop; other site 412418000957 ATP binding site [chemical binding]; other site 412418000958 Q-loop/lid; other site 412418000959 ABC transporter signature motif; other site 412418000960 Walker B; other site 412418000961 D-loop; other site 412418000962 H-loop/switch region; other site 412418000963 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 412418000964 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 412418000965 enolase; Provisional; Region: eno; PRK00077 412418000966 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 412418000967 dimer interface [polypeptide binding]; other site 412418000968 metal binding site [ion binding]; metal-binding site 412418000969 substrate binding pocket [chemical binding]; other site 412418000970 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 412418000971 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 412418000972 23S rRNA interface [nucleotide binding]; other site 412418000973 L3 interface [polypeptide binding]; other site 412418000974 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412418000975 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 412418000976 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 412418000977 GatB domain; Region: GatB_Yqey; smart00845 412418000978 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 412418000979 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 412418000980 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 412418000981 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 412418000982 Part of AAA domain; Region: AAA_19; pfam13245 412418000983 Family description; Region: UvrD_C_2; pfam13538 412418000984 Helix-turn-helix domain; Region: HTH_25; pfam13413 412418000985 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 412418000986 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 412418000987 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 412418000988 Domain of unknown function (DUF814); Region: DUF814; pfam05670 412418000989 pyruvate kinase; Provisional; Region: PRK05826 412418000990 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 412418000991 domain interfaces; other site 412418000992 active site 412418000993 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 412418000994 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 412418000995 RNA methyltransferase, RsmE family; Region: TIGR00046 412418000996 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 412418000997 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 412418000998 C-terminal peptidase (prc); Region: prc; TIGR00225 412418000999 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 412418001000 protein binding site [polypeptide binding]; other site 412418001001 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 412418001002 Catalytic dyad [active] 412418001003 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 412418001004 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 412418001005 P-loop; other site 412418001006 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 412418001007 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 412418001008 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 412418001009 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 412418001010 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 412418001011 oligomer interface [polypeptide binding]; other site 412418001012 putative active site [active] 412418001013 metal binding site [ion binding]; metal-binding site 412418001014 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 412418001015 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 412418001016 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 412418001017 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 412418001018 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 412418001019 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 412418001020 active site 412418001021 HIGH motif; other site 412418001022 dimer interface [polypeptide binding]; other site 412418001023 KMSKS motif; other site 412418001024 S4 domain; Region: S4; pfam01479 412418001025 RNA binding surface [nucleotide binding]; other site 412418001026 glycyl-tRNA synthetase; Provisional; Region: PRK04173 412418001027 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 412418001028 dimer interface [polypeptide binding]; other site 412418001029 motif 1; other site 412418001030 active site 412418001031 motif 2; other site 412418001032 motif 3; other site 412418001033 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 412418001034 anticodon binding site; other site 412418001035 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 412418001036 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 412418001037 active site 412418001038 HIGH motif; other site 412418001039 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 412418001040 active site 412418001041 KMSKS motif; other site 412418001042 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 412418001043 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412418001044 Zn2+ binding site [ion binding]; other site 412418001045 Mg2+ binding site [ion binding]; other site 412418001046 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 412418001047 S-adenosylmethionine synthetase; Validated; Region: PRK05250 412418001048 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 412418001049 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 412418001050 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 412418001051 S-ribosylhomocysteinase; Provisional; Region: PRK02260 412418001052 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 412418001053 HIT family signature motif; other site 412418001054 catalytic residue [active] 412418001055 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 412418001056 MgtE intracellular N domain; Region: MgtE_N; smart00924 412418001057 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 412418001058 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 412418001059 Divalent cation transporter; Region: MgtE; pfam01769 412418001060 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 412418001061 Trehalase; Region: Trehalase; cl17346 412418001062 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 412418001063 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 412418001064 ligand binding site [chemical binding]; other site 412418001065 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 412418001066 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 412418001067 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 412418001068 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 412418001069 ligand binding site [chemical binding]; other site 412418001070 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 412418001071 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 412418001072 ligand binding site [chemical binding]; other site 412418001073 30S ribosomal protein S7; Validated; Region: PRK05302 412418001074 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 412418001075 S17 interaction site [polypeptide binding]; other site 412418001076 S8 interaction site; other site 412418001077 16S rRNA interaction site [nucleotide binding]; other site 412418001078 streptomycin interaction site [chemical binding]; other site 412418001079 23S rRNA interaction site [nucleotide binding]; other site 412418001080 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 412418001081 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 412418001082 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 412418001083 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 412418001084 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 412418001085 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 412418001086 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 412418001087 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 412418001088 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 412418001089 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 412418001090 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 412418001091 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 412418001092 DNA binding site [nucleotide binding] 412418001093 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 412418001094 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 412418001095 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 412418001096 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 412418001097 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 412418001098 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 412418001099 RPB10 interaction site [polypeptide binding]; other site 412418001100 RPB1 interaction site [polypeptide binding]; other site 412418001101 RPB11 interaction site [polypeptide binding]; other site 412418001102 RPB3 interaction site [polypeptide binding]; other site 412418001103 RPB12 interaction site [polypeptide binding]; other site 412418001104 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 412418001105 core dimer interface [polypeptide binding]; other site 412418001106 peripheral dimer interface [polypeptide binding]; other site 412418001107 L10 interface [polypeptide binding]; other site 412418001108 L11 interface [polypeptide binding]; other site 412418001109 putative EF-Tu interaction site [polypeptide binding]; other site 412418001110 putative EF-G interaction site [polypeptide binding]; other site 412418001111 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 412418001112 23S rRNA interface [nucleotide binding]; other site 412418001113 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 412418001114 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 412418001115 mRNA/rRNA interface [nucleotide binding]; other site 412418001116 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 412418001117 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 412418001118 23S rRNA interface [nucleotide binding]; other site 412418001119 L7/L12 interface [polypeptide binding]; other site 412418001120 putative thiostrepton binding site; other site 412418001121 L25 interface [polypeptide binding]; other site 412418001122 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 412418001123 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 412418001124 putative homodimer interface [polypeptide binding]; other site 412418001125 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 412418001126 heterodimer interface [polypeptide binding]; other site 412418001127 homodimer interface [polypeptide binding]; other site 412418001128 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 412418001129 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 412418001130 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 412418001131 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 412418001132 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412418001133 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 412418001134 prolyl-tRNA synthetase; Provisional; Region: PRK08661 412418001135 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 412418001136 dimer interface [polypeptide binding]; other site 412418001137 motif 1; other site 412418001138 active site 412418001139 motif 2; other site 412418001140 motif 3; other site 412418001141 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 412418001142 anticodon binding site; other site 412418001143 zinc-binding site [ion binding]; other site 412418001144 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 412418001145 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 412418001146 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 412418001147 mannose-6-phosphate isomerase; Region: PLN02288 412418001148 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 412418001149 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 412418001150 active site 412418001151 phosphorylation site [posttranslational modification] 412418001152 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 412418001153 active site 412418001154 P-loop; other site 412418001155 phosphorylation site [posttranslational modification] 412418001156 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 412418001157 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 412418001158 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 412418001159 active site 412418001160 substrate binding site [chemical binding]; other site 412418001161 Mg2+ binding site [ion binding]; other site 412418001162 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 412418001163 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 412418001164 active site 412418001165 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 412418001166 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 412418001167 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 412418001168 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 412418001169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412418001170 active site 412418001171 phosphorylation site [posttranslational modification] 412418001172 intermolecular recognition site; other site 412418001173 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 412418001174 CheB methylesterase; Region: CheB_methylest; pfam01339 412418001175 TraB family; Region: TraB; cl12050 412418001176 adenylate kinase; Provisional; Region: PRK14526 412418001177 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 412418001178 AMP-binding site [chemical binding]; other site 412418001179 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 412418001180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412418001181 active site 412418001182 phosphorylation site [posttranslational modification] 412418001183 intermolecular recognition site; other site 412418001184 dimerization interface [polypeptide binding]; other site 412418001185 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 412418001186 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 412418001187 metal binding site [ion binding]; metal-binding site 412418001188 active site 412418001189 I-site; other site 412418001190 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412418001191 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 412418001192 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 412418001193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412418001194 dimer interface [polypeptide binding]; other site 412418001195 phosphorylation site [posttranslational modification] 412418001196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412418001197 ATP binding site [chemical binding]; other site 412418001198 Mg2+ binding site [ion binding]; other site 412418001199 G-X-G motif; other site 412418001200 Response regulator receiver domain; Region: Response_reg; pfam00072 412418001201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412418001202 active site 412418001203 phosphorylation site [posttranslational modification] 412418001204 intermolecular recognition site; other site 412418001205 dimerization interface [polypeptide binding]; other site 412418001206 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 412418001207 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 412418001208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412418001209 active site 412418001210 motif I; other site 412418001211 motif II; other site 412418001212 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412418001213 active site 412418001214 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 412418001215 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 412418001216 GDP-binding site [chemical binding]; other site 412418001217 ACT binding site; other site 412418001218 IMP binding site; other site 412418001219 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 412418001220 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 412418001221 tetramer interface [polypeptide binding]; other site 412418001222 active site 412418001223 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 412418001224 active site 412418001225 DNA binding site [nucleotide binding] 412418001226 Predicted methyltransferases [General function prediction only]; Region: COG0313 412418001227 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 412418001228 putative SAM binding site [chemical binding]; other site 412418001229 putative homodimer interface [polypeptide binding]; other site 412418001230 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 412418001231 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 412418001232 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 412418001233 ParB-like nuclease domain; Region: ParB; smart00470 412418001234 DNA gyrase subunit A; Validated; Region: PRK05560 412418001235 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 412418001236 CAP-like domain; other site 412418001237 active site 412418001238 primary dimer interface [polypeptide binding]; other site 412418001239 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412418001240 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412418001241 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412418001242 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412418001243 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412418001244 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412418001245 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 412418001246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412418001247 Mg2+ binding site [ion binding]; other site 412418001248 G-X-G motif; other site 412418001249 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 412418001250 anchoring element; other site 412418001251 dimer interface [polypeptide binding]; other site 412418001252 ATP binding site [chemical binding]; other site 412418001253 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 412418001254 active site 412418001255 putative metal-binding site [ion binding]; other site 412418001256 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 412418001257 DnaA N-terminal domain; Region: DnaA_N; pfam11638 412418001258 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 412418001259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412418001260 Walker A motif; other site 412418001261 ATP binding site [chemical binding]; other site 412418001262 Walker B motif; other site 412418001263 arginine finger; other site 412418001264 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 412418001265 DnaA box-binding interface [nucleotide binding]; other site 412418001266 DNA polymerase III subunit beta; Validated; Region: PRK05643 412418001267 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 412418001268 putative DNA binding surface [nucleotide binding]; other site 412418001269 dimer interface [polypeptide binding]; other site 412418001270 beta-clamp/clamp loader binding surface; other site 412418001271 beta-clamp/translesion DNA polymerase binding surface; other site 412418001272 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 412418001273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418001274 Walker A/P-loop; other site 412418001275 ATP binding site [chemical binding]; other site 412418001276 Q-loop/lid; other site 412418001277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418001278 ABC transporter signature motif; other site 412418001279 Walker B; other site 412418001280 D-loop; other site 412418001281 H-loop/switch region; other site 412418001282 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 412418001283 Ribonuclease P; Region: Ribonuclease_P; pfam00825 412418001284 membrane protein insertase; Provisional; Region: PRK01318 412418001285 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 412418001286 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 412418001287 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 412418001288 G-X-X-G motif; other site 412418001289 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 412418001290 RxxxH motif; other site 412418001291 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 412418001292 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 412418001293 putative NAD(P) binding site [chemical binding]; other site 412418001294 active site 412418001295 putative substrate binding site [chemical binding]; other site 412418001296 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 412418001297 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 412418001298 active site 412418001299 intersubunit interface [polypeptide binding]; other site 412418001300 zinc binding site [ion binding]; other site 412418001301 Na+ binding site [ion binding]; other site 412418001302 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 412418001303 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 412418001304 putative dimer interface [polypeptide binding]; other site 412418001305 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 412418001306 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 412418001307 dimer interface [polypeptide binding]; other site 412418001308 anticodon binding site; other site 412418001309 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 412418001310 homodimer interface [polypeptide binding]; other site 412418001311 motif 1; other site 412418001312 active site 412418001313 motif 2; other site 412418001314 GAD domain; Region: GAD; pfam02938 412418001315 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 412418001316 active site 412418001317 motif 3; other site 412418001318 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 412418001319 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 412418001320 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 412418001321 active site 412418001322 phosphorylation site [posttranslational modification] 412418001323 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 412418001324 dimerization domain swap beta strand [polypeptide binding]; other site 412418001325 regulatory protein interface [polypeptide binding]; other site 412418001326 active site 412418001327 regulatory phosphorylation site [posttranslational modification]; other site 412418001328 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 412418001329 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 412418001330 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 412418001331 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 412418001332 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 412418001333 Chromate transporter; Region: Chromate_transp; pfam02417 412418001334 Chromate transporter; Region: Chromate_transp; pfam02417 412418001335 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 412418001336 Mechanosensitive ion channel; Region: MS_channel; pfam00924 412418001337 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 412418001338 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 412418001339 putative ADP-binding pocket [chemical binding]; other site 412418001340 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 412418001341 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 412418001342 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 412418001343 GIY-YIG motif/motif A; other site 412418001344 active site 412418001345 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14670 412418001346 catalytic site [active] 412418001347 putative DNA binding site [nucleotide binding]; other site 412418001348 metal binding site [ion binding]; metal-binding site 412418001349 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 412418001350 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 412418001351 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 412418001352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418001353 binding surface 412418001354 Tetratricopeptide repeat; Region: TPR_16; pfam13432 412418001355 TPR motif; other site 412418001356 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 412418001357 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06647 412418001358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412418001359 Walker A motif; other site 412418001360 ATP binding site [chemical binding]; other site 412418001361 Walker B motif; other site 412418001362 arginine finger; other site 412418001363 hypothetical protein; Provisional; Region: PRK14629 412418001364 recombination protein RecR; Reviewed; Region: recR; PRK00076 412418001365 RecR protein; Region: RecR; pfam02132 412418001366 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 412418001367 putative active site [active] 412418001368 putative metal-binding site [ion binding]; other site 412418001369 tetramer interface [polypeptide binding]; other site 412418001370 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 412418001371 active site 412418001372 multimer interface [polypeptide binding]; other site 412418001373 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 412418001374 OstA-like protein; Region: OstA; cl00844 412418001375 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 412418001376 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 412418001377 Walker A/P-loop; other site 412418001378 ATP binding site [chemical binding]; other site 412418001379 Q-loop/lid; other site 412418001380 ABC transporter signature motif; other site 412418001381 Walker B; other site 412418001382 D-loop; other site 412418001383 H-loop/switch region; other site 412418001384 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 412418001385 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 412418001386 Uncharacterized conserved protein [Function unknown]; Region: COG0327 412418001387 signal peptidase II; Provisional; Region: lspA; PRK01574 412418001388 lipoprotein signal peptidase; Provisional; Region: PRK14787 412418001389 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 412418001390 active site 412418001391 metal binding site [ion binding]; metal-binding site 412418001392 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 412418001393 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 412418001394 hinge; other site 412418001395 active site 412418001396 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 412418001397 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 412418001398 elongation factor Tu; Reviewed; Region: PRK00049 412418001399 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 412418001400 G1 box; other site 412418001401 GEF interaction site [polypeptide binding]; other site 412418001402 GTP/Mg2+ binding site [chemical binding]; other site 412418001403 Switch I region; other site 412418001404 G2 box; other site 412418001405 G3 box; other site 412418001406 Switch II region; other site 412418001407 G4 box; other site 412418001408 G5 box; other site 412418001409 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 412418001410 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 412418001411 Antibiotic Binding Site [chemical binding]; other site 412418001412 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 412418001413 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 412418001414 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 412418001415 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 412418001416 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 412418001417 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 412418001418 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 412418001419 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 412418001420 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 412418001421 putative translocon binding site; other site 412418001422 protein-rRNA interface [nucleotide binding]; other site 412418001423 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 412418001424 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 412418001425 G-X-X-G motif; other site 412418001426 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 412418001427 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 412418001428 23S rRNA interface [nucleotide binding]; other site 412418001429 5S rRNA interface [nucleotide binding]; other site 412418001430 putative antibiotic binding site [chemical binding]; other site 412418001431 L25 interface [polypeptide binding]; other site 412418001432 L27 interface [polypeptide binding]; other site 412418001433 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 412418001434 23S rRNA interface [nucleotide binding]; other site 412418001435 putative translocon interaction site; other site 412418001436 signal recognition particle (SRP54) interaction site; other site 412418001437 L23 interface [polypeptide binding]; other site 412418001438 trigger factor interaction site; other site 412418001439 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 412418001440 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 412418001441 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 412418001442 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 412418001443 RNA binding site [nucleotide binding]; other site 412418001444 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 412418001445 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 412418001446 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 412418001447 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 412418001448 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 412418001449 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 412418001450 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 412418001451 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 412418001452 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 412418001453 5S rRNA interface [nucleotide binding]; other site 412418001454 L27 interface [polypeptide binding]; other site 412418001455 23S rRNA interface [nucleotide binding]; other site 412418001456 L5 interface [polypeptide binding]; other site 412418001457 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 412418001458 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 412418001459 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 412418001460 50S ribosomal protein L30; Reviewed; Region: rpmD; PRK05611 412418001461 23S rRNA binding site - archaea [nucleotide binding]; other site 412418001462 23S rRNA binding site - prokaryotes [nucleotide binding]; other site 412418001463 5S rRNA binding site - archaea; other site 412418001464 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 412418001465 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 412418001466 SecY translocase; Region: SecY; pfam00344 412418001467 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 412418001468 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 412418001469 30S ribosomal protein S13; Region: bact_S13; TIGR03631 412418001470 30S ribosomal protein S11; Validated; Region: PRK05309 412418001471 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 412418001472 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 412418001473 alphaNTD - beta interaction site [polypeptide binding]; other site 412418001474 alphaNTD homodimer interface [polypeptide binding]; other site 412418001475 alphaNTD - beta' interaction site [polypeptide binding]; other site 412418001476 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 412418001477 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 412418001478 phosphodiesterase; Provisional; Region: PRK12704 412418001479 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 412418001480 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 412418001481 Zn2+ binding site [ion binding]; other site 412418001482 Mg2+ binding site [ion binding]; other site 412418001483 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 412418001484 putative active site [active] 412418001485 metal binding site [ion binding]; metal-binding site 412418001486 homodimer binding site [polypeptide binding]; other site 412418001487 hemolysin TlyA family protein; Region: tly; TIGR00478 412418001488 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 412418001489 RNA binding surface [nucleotide binding]; other site 412418001490 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 412418001491 Sporulation and spore germination; Region: Germane; pfam10646 412418001492 GTP-binding protein Der; Reviewed; Region: PRK00093 412418001493 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 412418001494 G1 box; other site 412418001495 GTP/Mg2+ binding site [chemical binding]; other site 412418001496 G2 box; other site 412418001497 Switch I region; other site 412418001498 G3 box; other site 412418001499 Switch II region; other site 412418001500 G4 box; other site 412418001501 G5 box; other site 412418001502 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 412418001503 G1 box; other site 412418001504 GTP/Mg2+ binding site [chemical binding]; other site 412418001505 Switch I region; other site 412418001506 G2 box; other site 412418001507 G3 box; other site 412418001508 Switch II region; other site 412418001509 G4 box; other site 412418001510 G5 box; other site 412418001511 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 412418001512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412418001513 motif II; other site 412418001514 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 412418001515 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 412418001516 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 412418001517 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 412418001518 dimer interface [polypeptide binding]; other site 412418001519 motif 1; other site 412418001520 active site 412418001521 motif 2; other site 412418001522 motif 3; other site 412418001523 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK09616 412418001524 tRNA synthetase B5 domain; Region: B5; pfam03484 412418001525 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 412418001526 dimer interface [polypeptide binding]; other site 412418001527 motif 1; other site 412418001528 motif 3; other site 412418001529 motif 2; other site 412418001530 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 412418001531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412418001532 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412418001533 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 412418001534 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 412418001535 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 412418001536 chaperone protein DnaJ; Provisional; Region: PRK14285 412418001537 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 412418001538 HSP70 interaction site [polypeptide binding]; other site 412418001539 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 412418001540 substrate binding site [polypeptide binding]; other site 412418001541 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 412418001542 Zn binding sites [ion binding]; other site 412418001543 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 412418001544 dimer interface [polypeptide binding]; other site 412418001545 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 412418001546 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 412418001547 nucleotide binding site [chemical binding]; other site 412418001548 NEF interaction site [polypeptide binding]; other site 412418001549 SBD interface [polypeptide binding]; other site 412418001550 GrpE; Region: GrpE; pfam01025 412418001551 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 412418001552 dimer interface [polypeptide binding]; other site 412418001553 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 412418001554 NAD synthetase; Provisional; Region: PRK13981 412418001555 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 412418001556 catalytic triad [active] 412418001557 dimer interface [polypeptide binding]; other site 412418001558 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 412418001559 homodimer interface [polypeptide binding]; other site 412418001560 NAD binding pocket [chemical binding]; other site 412418001561 ATP binding pocket [chemical binding]; other site 412418001562 Mg binding site [ion binding]; other site 412418001563 active-site loop [active] 412418001564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412418001565 active site 412418001566 phosphorylation site [posttranslational modification] 412418001567 dimerization interface [polypeptide binding]; other site 412418001568 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 412418001569 pantothenate kinase; Reviewed; Region: PRK13326 412418001570 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 412418001571 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 412418001572 putative hydrolase; Provisional; Region: PRK02113 412418001573 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 412418001574 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 412418001575 putative catalytic site [active] 412418001576 putative metal binding site [ion binding]; other site 412418001577 putative phosphate binding site [ion binding]; other site 412418001578 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 412418001579 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 412418001580 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 412418001581 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 412418001582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418001583 TPR motif; other site 412418001584 binding surface 412418001585 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 412418001586 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 412418001587 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 412418001588 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 412418001589 translation elongation factor EF-G; Region: EF-G; TIGR00484 412418001590 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 412418001591 G1 box; other site 412418001592 putative GEF interaction site [polypeptide binding]; other site 412418001593 GTP/Mg2+ binding site [chemical binding]; other site 412418001594 Switch I region; other site 412418001595 G2 box; other site 412418001596 G3 box; other site 412418001597 Switch II region; other site 412418001598 G4 box; other site 412418001599 G5 box; other site 412418001600 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 412418001601 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 412418001602 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 412418001603 KTSC domain; Region: KTSC; pfam13619 412418001604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418001605 binding surface 412418001606 TPR motif; other site 412418001607 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 412418001608 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 412418001609 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412418001610 active site 412418001611 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 412418001612 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 412418001613 nucleotide binding site [chemical binding]; other site 412418001614 Sporulation related domain; Region: SPOR; pfam05036 412418001615 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 412418001616 CoA-binding site [chemical binding]; other site 412418001617 DNA polymerase I; Provisional; Region: PRK05755 412418001618 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 412418001619 active site 412418001620 metal binding site 1 [ion binding]; metal-binding site 412418001621 putative 5' ssDNA interaction site; other site 412418001622 metal binding site 3; metal-binding site 412418001623 metal binding site 2 [ion binding]; metal-binding site 412418001624 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 412418001625 putative DNA binding site [nucleotide binding]; other site 412418001626 putative metal binding site [ion binding]; other site 412418001627 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 412418001628 active site 412418001629 catalytic site [active] 412418001630 substrate binding site [chemical binding]; other site 412418001631 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 412418001632 active site 412418001633 DNA binding site [nucleotide binding] 412418001634 catalytic site [active] 412418001635 Flagellar protein FliS; Region: FliS; cl00654 412418001636 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 412418001637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412418001638 active site 412418001639 phosphorylation site [posttranslational modification] 412418001640 intermolecular recognition site; other site 412418001641 dimerization interface [polypeptide binding]; other site 412418001642 NAD-dependent DNA ligase LigA; Provisional; Region: ligA; PRK14350 412418001643 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 412418001644 nucleotide binding pocket [chemical binding]; other site 412418001645 K-X-D-G motif; other site 412418001646 catalytic site [active] 412418001647 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 412418001648 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 412418001649 Dimer interface [polypeptide binding]; other site 412418001650 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 412418001651 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 412418001652 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 412418001653 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 412418001654 dimerization domain swap beta strand [polypeptide binding]; other site 412418001655 regulatory protein interface [polypeptide binding]; other site 412418001656 active site 412418001657 regulatory phosphorylation site [posttranslational modification]; other site 412418001658 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 412418001659 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 412418001660 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 412418001661 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 412418001662 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 412418001663 HPr interaction site; other site 412418001664 glycerol kinase (GK) interaction site [polypeptide binding]; other site 412418001665 active site 412418001666 phosphorylation site [posttranslational modification] 412418001667 heat shock protein 90; Provisional; Region: PRK05218 412418001668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412418001669 ATP binding site [chemical binding]; other site 412418001670 Mg2+ binding site [ion binding]; other site 412418001671 G-X-G motif; other site 412418001672 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 412418001673 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 412418001674 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 412418001675 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 412418001676 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 412418001677 Protein of unknown function (DUF3996); Region: DUF3996; pfam13161 412418001678 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 412418001679 putative CheA interaction surface; other site 412418001680 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 412418001681 anti sigma factor interaction site; other site 412418001682 regulatory phosphorylation site [posttranslational modification]; other site 412418001683 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 412418001684 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 412418001685 putative binding surface; other site 412418001686 active site 412418001687 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 412418001688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412418001689 ATP binding site [chemical binding]; other site 412418001690 Mg2+ binding site [ion binding]; other site 412418001691 G-X-G motif; other site 412418001692 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 412418001693 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 412418001694 CheB methylesterase; Region: CheB_methylest; pfam01339 412418001695 Response regulator receiver domain; Region: Response_reg; pfam00072 412418001696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412418001697 active site 412418001698 phosphorylation site [posttranslational modification] 412418001699 intermolecular recognition site; other site 412418001700 dimerization interface [polypeptide binding]; other site 412418001701 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 412418001702 hypothetical protein; Provisional; Region: PRK07205 412418001703 active site 412418001704 metal binding site [ion binding]; metal-binding site 412418001705 AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back...; Region: AAK_UMPK-PyrH-Pf; cd04253 412418001706 nucleotide binding site [chemical binding]; other site 412418001707 homodimeric interface [polypeptide binding]; other site 412418001708 uridine monophosphate binding site [chemical binding]; other site 412418001709 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 412418001710 active site 412418001711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418001712 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 412418001713 Walker A/P-loop; other site 412418001714 ATP binding site [chemical binding]; other site 412418001715 Q-loop/lid; other site 412418001716 ABC transporter signature motif; other site 412418001717 Walker B; other site 412418001718 D-loop; other site 412418001719 H-loop/switch region; other site 412418001720 CTP synthetase; Validated; Region: pyrG; PRK05380 412418001721 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 412418001722 Catalytic site [active] 412418001723 active site 412418001724 UTP binding site [chemical binding]; other site 412418001725 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 412418001726 active site 412418001727 putative oxyanion hole; other site 412418001728 catalytic triad [active] 412418001729 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 412418001730 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412418001731 putative CheW interface [polypeptide binding]; other site 412418001732 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 412418001733 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 412418001734 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 412418001735 active site 412418001736 PHP Thumb interface [polypeptide binding]; other site 412418001737 metal binding site [ion binding]; metal-binding site 412418001738 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 412418001739 generic binding surface I; other site 412418001740 generic binding surface II; other site 412418001741 YGGT family; Region: YGGT; pfam02325 412418001742 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 412418001743 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412418001744 ATP binding site [chemical binding]; other site 412418001745 putative Mg++ binding site [ion binding]; other site 412418001746 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412418001747 nucleotide binding region [chemical binding]; other site 412418001748 ATP-binding site [chemical binding]; other site 412418001749 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 412418001750 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 412418001751 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 412418001752 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 412418001753 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412418001754 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412418001755 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 412418001756 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 412418001757 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 412418001758 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 412418001759 active site 412418001760 HIGH motif; other site 412418001761 KMSKS motif; other site 412418001762 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 412418001763 tRNA binding surface [nucleotide binding]; other site 412418001764 anticodon binding site; other site 412418001765 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cd02153 412418001766 putative tRNA-binding site [nucleotide binding]; other site 412418001767 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 412418001768 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 412418001769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412418001770 S-adenosylmethionine binding site [chemical binding]; other site 412418001771 Competence protein; Region: Competence; pfam03772 412418001772 CAAX protease self-immunity; Region: Abi; pfam02517 412418001773 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 412418001774 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 412418001775 acyl-activating enzyme (AAE) consensus motif; other site 412418001776 AMP binding site [chemical binding]; other site 412418001777 active site 412418001778 CoA binding site [chemical binding]; other site 412418001779 arginyl-tRNA synthetase; Region: argS; TIGR00456 412418001780 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 412418001781 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 412418001782 active site 412418001783 HIGH motif; other site 412418001784 KMSK motif region; other site 412418001785 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 412418001786 tRNA binding surface [nucleotide binding]; other site 412418001787 anticodon binding site; other site 412418001788 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412418001789 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412418001790 dimer interface [polypeptide binding]; other site 412418001791 putative CheW interface [polypeptide binding]; other site 412418001792 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412418001793 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412418001794 dimer interface [polypeptide binding]; other site 412418001795 putative CheW interface [polypeptide binding]; other site 412418001796 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14650 412418001797 FAD binding domain; Region: FAD_binding_4; pfam01565 412418001798 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 412418001799 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14534 412418001800 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412418001801 active site 412418001802 HIGH motif; other site 412418001803 nucleotide binding site [chemical binding]; other site 412418001804 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412418001805 active site 412418001806 KMSKS motif; other site 412418001807 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 412418001808 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 412418001809 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 412418001810 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 412418001811 dimer interface [polypeptide binding]; other site 412418001812 active site 412418001813 glycine-pyridoxal phosphate binding site [chemical binding]; other site 412418001814 folate binding site [chemical binding]; other site 412418001815 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 412418001816 HSP70 interaction site [polypeptide binding]; other site 412418001817 Borrelia burgdorferi attachment protein P66; Region: Attachment_P66; pfam11263 412418001818 L-lactate permease; Region: Lactate_perm; cl00701 412418001819 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 412418001820 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 412418001821 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 412418001822 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13494 412418001823 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 412418001824 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 412418001825 metal binding site [ion binding]; metal-binding site 412418001826 dimer interface [polypeptide binding]; other site 412418001827 trigger factor; Provisional; Region: tig; PRK01490 412418001828 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 412418001829 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 412418001830 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 412418001831 oligomer interface [polypeptide binding]; other site 412418001832 active site residues [active] 412418001833 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 412418001834 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 412418001835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412418001836 Walker A motif; other site 412418001837 ATP binding site [chemical binding]; other site 412418001838 Walker B motif; other site 412418001839 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 412418001840 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 412418001841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412418001842 Walker A motif; other site 412418001843 ATP binding site [chemical binding]; other site 412418001844 Walker B motif; other site 412418001845 arginine finger; other site 412418001846 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 412418001847 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 412418001848 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 412418001849 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412418001850 RNA binding surface [nucleotide binding]; other site 412418001851 Cation efflux family; Region: Cation_efflux; pfam01545 412418001852 Cation efflux family; Region: Cation_efflux; cl00316 412418001853 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 412418001854 active site 412418001855 catalytic motif [active] 412418001856 Zn binding site [ion binding]; other site 412418001857 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 412418001858 DHH family; Region: DHH; pfam01368 412418001859 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 412418001860 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 412418001861 DJ-1 family protein; Region: not_thiJ; TIGR01383 412418001862 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 412418001863 conserved cys residue [active] 412418001864 propionate/acetate kinase; Provisional; Region: PRK12379 412418001865 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 412418001866 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 412418001867 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 412418001868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412418001869 ATP binding site [chemical binding]; other site 412418001870 putative Mg++ binding site [ion binding]; other site 412418001871 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412418001872 nucleotide binding region [chemical binding]; other site 412418001873 ATP-binding site [chemical binding]; other site 412418001874 TRCF domain; Region: TRCF; pfam03461 412418001875 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412418001876 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412418001877 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 412418001878 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412418001879 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 412418001880 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 412418001881 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412418001882 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 412418001883 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 412418001884 active site 412418001885 metal binding site [ion binding]; metal-binding site 412418001886 putative aminopeptidase 2; Provisional; Region: PRK02813 412418001887 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 412418001888 metal binding site [ion binding]; metal-binding site 412418001889 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 412418001890 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 412418001891 active site 412418001892 phosphorylation site [posttranslational modification] 412418001893 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 412418001894 active site 412418001895 P-loop; other site 412418001896 phosphorylation site [posttranslational modification] 412418001897 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 412418001898 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 412418001899 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 412418001900 putative substrate binding site [chemical binding]; other site 412418001901 putative ATP binding site [chemical binding]; other site 412418001902 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 412418001903 AAA domain; Region: AAA_30; pfam13604 412418001904 Family description; Region: UvrD_C_2; pfam13538 412418001905 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 412418001906 Part of AAA domain; Region: AAA_19; pfam13245 412418001907 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 412418001908 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 412418001909 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 412418001910 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 412418001911 active site 412418001912 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 412418001913 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 412418001914 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 412418001915 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 412418001916 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 412418001917 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 412418001918 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 412418001919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412418001920 ABC-ATPase subunit interface; other site 412418001921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412418001922 dimer interface [polypeptide binding]; other site 412418001923 conserved gate region; other site 412418001924 putative PBP binding loops; other site 412418001925 ABC-ATPase subunit interface; other site 412418001926 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 412418001927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418001928 Walker A/P-loop; other site 412418001929 ATP binding site [chemical binding]; other site 412418001930 Q-loop/lid; other site 412418001931 ABC transporter signature motif; other site 412418001932 Walker B; other site 412418001933 D-loop; other site 412418001934 H-loop/switch region; other site 412418001935 TOBE domain; Region: TOBE_2; pfam08402 412418001936 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 412418001937 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 412418001938 GTP/Mg2+ binding site [chemical binding]; other site 412418001939 G4 box; other site 412418001940 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 412418001941 G1 box; other site 412418001942 G1 box; other site 412418001943 GTP/Mg2+ binding site [chemical binding]; other site 412418001944 Switch I region; other site 412418001945 G2 box; other site 412418001946 G2 box; other site 412418001947 Switch I region; other site 412418001948 G3 box; other site 412418001949 G3 box; other site 412418001950 Switch II region; other site 412418001951 Switch II region; other site 412418001952 G4 box; other site 412418001953 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 412418001954 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 412418001955 putative active site cavity [active] 412418001956 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 412418001957 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 412418001958 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 412418001959 active site turn [active] 412418001960 phosphorylation site [posttranslational modification] 412418001961 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 412418001962 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 412418001963 metal binding site 2 [ion binding]; metal-binding site 412418001964 putative DNA binding helix; other site 412418001965 metal binding site 1 [ion binding]; metal-binding site 412418001966 structural Zn2+ binding site [ion binding]; other site 412418001967 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 412418001968 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 412418001969 ring oligomerisation interface [polypeptide binding]; other site 412418001970 ATP/Mg binding site [chemical binding]; other site 412418001971 stacking interactions; other site 412418001972 hinge regions; other site 412418001973 Preprotein translocase subunit; Region: YajC; pfam02699 412418001974 protein-export membrane protein SecD; Region: secD; TIGR01129 412418001975 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 412418001976 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 412418001977 Protein export membrane protein; Region: SecD_SecF; pfam02355 412418001978 chaperone protein DnaJ; Provisional; Region: PRK14299 412418001979 DnaJ domain; Region: DnaJ; pfam00226 412418001980 HSP70 interaction site [polypeptide binding]; other site 412418001981 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 412418001982 substrate binding site [polypeptide binding]; other site 412418001983 dimer interface [polypeptide binding]; other site 412418001984 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 412418001985 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 412418001986 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412418001987 active site 412418001988 dimer interface [polypeptide binding]; other site 412418001989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412418001990 catalytic core [active] 412418001991 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412418001992 lysyl-tRNA synthetase, archaeal and spirochete; Region: lysS_arch; TIGR00467 412418001993 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 412418001994 active site 412418001995 HIGH motif; other site 412418001996 KMSKS motif; other site 412418001997 GTPase Era; Reviewed; Region: era; PRK00089 412418001998 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 412418001999 G1 box; other site 412418002000 GTP/Mg2+ binding site [chemical binding]; other site 412418002001 Switch I region; other site 412418002002 G2 box; other site 412418002003 Switch II region; other site 412418002004 G3 box; other site 412418002005 G4 box; other site 412418002006 G5 box; other site 412418002007 Double zinc ribbon; Region: DZR; pfam12773 412418002008 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 412418002009 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412418002010 active site 412418002011 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 412418002012 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 412418002013 active site 412418002014 metal binding site [ion binding]; metal-binding site 412418002015 Sporulation and spore germination; Region: Germane; cl11253 412418002016 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 412418002017 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 412418002018 putative binding surface; other site 412418002019 active site 412418002020 P2 response regulator binding domain; Region: P2; pfam07194 412418002021 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 412418002022 P2 response regulator binding domain; Region: P2; pfam07194 412418002023 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 412418002024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412418002025 ATP binding site [chemical binding]; other site 412418002026 Mg2+ binding site [ion binding]; other site 412418002027 G-X-G motif; other site 412418002028 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 412418002029 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 412418002030 putative CheA interaction surface; other site 412418002031 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 412418002032 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 412418002033 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 412418002034 Response regulator receiver domain; Region: Response_reg; pfam00072 412418002035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412418002036 active site 412418002037 phosphorylation site [posttranslational modification] 412418002038 intermolecular recognition site; other site 412418002039 dimerization interface [polypeptide binding]; other site 412418002040 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 412418002041 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 412418002042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412418002043 motif II; other site 412418002044 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 412418002045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418002046 Walker A/P-loop; other site 412418002047 ATP binding site [chemical binding]; other site 412418002048 Q-loop/lid; other site 412418002049 ABC transporter signature motif; other site 412418002050 Walker B; other site 412418002051 D-loop; other site 412418002052 H-loop/switch region; other site 412418002053 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 412418002054 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 412418002055 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412418002056 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 412418002057 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 412418002058 TM-ABC transporter signature motif; other site 412418002059 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 412418002060 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 412418002061 TM-ABC transporter signature motif; other site 412418002062 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412418002063 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 412418002064 dimer interface [polypeptide binding]; other site 412418002065 putative CheW interface [polypeptide binding]; other site 412418002066 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 412418002067 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 412418002068 dimer interface [polypeptide binding]; other site 412418002069 putative CheW interface [polypeptide binding]; other site 412418002070 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 412418002071 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 412418002072 Ligand Binding Site [chemical binding]; other site 412418002073 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 412418002074 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 412418002075 dimer interface [polypeptide binding]; other site 412418002076 active site 412418002077 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 412418002078 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 412418002079 homotetramer interface [polypeptide binding]; other site 412418002080 FMN binding site [chemical binding]; other site 412418002081 homodimer contacts [polypeptide binding]; other site 412418002082 putative active site [active] 412418002083 putative substrate binding site [chemical binding]; other site 412418002084 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 412418002085 homodimer interface [polypeptide binding]; other site 412418002086 substrate binding pocket [chemical binding]; other site 412418002087 catalytic residues [active] 412418002088 NADH/NADPH cofactor binding site [chemical binding]; other site 412418002089 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 412418002090 diphosphomevalonate decarboxylase; Region: PLN02407 412418002091 Phosphomevalonate kinase [Lipid metabolism]; Region: ERG8; COG3890 412418002092 mevalonate kinase; Region: mevalon_kin; TIGR00549 412418002093 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 412418002094 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 412418002095 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 412418002096 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 412418002097 dimerization interface [polypeptide binding]; other site 412418002098 DPS ferroxidase diiron center [ion binding]; other site 412418002099 ion pore; other site 412418002100 elongation factor G; Reviewed; Region: PRK13351 412418002101 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 412418002102 G1 box; other site 412418002103 putative GEF interaction site [polypeptide binding]; other site 412418002104 GTP/Mg2+ binding site [chemical binding]; other site 412418002105 Switch I region; other site 412418002106 G2 box; other site 412418002107 G3 box; other site 412418002108 Switch II region; other site 412418002109 G4 box; other site 412418002110 G5 box; other site 412418002111 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 412418002112 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 412418002113 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 412418002114 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 412418002115 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 412418002116 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 412418002117 signal recognition particle protein; Provisional; Region: PRK10867 412418002118 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 412418002119 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 412418002120 P loop; other site 412418002121 GTP binding site [chemical binding]; other site 412418002122 Signal peptide binding domain; Region: SRP_SPB; pfam02978 412418002123 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 412418002124 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 412418002125 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 412418002126 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14594 412418002127 RimM N-terminal domain; Region: RimM; pfam01782 412418002128 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 412418002129 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 412418002130 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 412418002131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412418002132 active site 412418002133 nucleotide binding site [chemical binding]; other site 412418002134 HIGH motif; other site 412418002135 KMSKS motif; other site 412418002136 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 412418002137 acyl carrier protein; Provisional; Region: acpP; PRK00982 412418002138 ribonuclease III; Reviewed; Region: rnc; PRK00102 412418002139 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 412418002140 dimerization interface [polypeptide binding]; other site 412418002141 active site 412418002142 metal binding site [ion binding]; metal-binding site 412418002143 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 412418002144 dsRNA binding site [nucleotide binding]; other site 412418002145 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 412418002146 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 412418002147 active site 412418002148 NTP binding site [chemical binding]; other site 412418002149 metal binding triad [ion binding]; metal-binding site 412418002150 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 412418002151 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 412418002152 YceG-like family; Region: YceG; pfam02618 412418002153 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 412418002154 dimerization interface [polypeptide binding]; other site 412418002155 DNA primase, catalytic core; Region: dnaG; TIGR01391 412418002156 CHC2 zinc finger; Region: zf-CHC2; pfam01807 412418002157 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 412418002158 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 412418002159 active site 412418002160 metal binding site [ion binding]; metal-binding site 412418002161 interdomain interaction site; other site 412418002162 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 412418002163 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 412418002164 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 412418002165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412418002166 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 412418002167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412418002168 DNA binding residues [nucleotide binding] 412418002169 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 412418002170 Putative zinc ribbon domain; Region: DUF164; pfam02591 412418002171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 412418002172 binding surface 412418002173 TPR motif; other site 412418002174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418002175 TPR motif; other site 412418002176 TPR repeat; Region: TPR_11; pfam13414 412418002177 binding surface 412418002178 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 412418002179 MreB and similar proteins; Region: MreB_like; cd10225 412418002180 nucleotide binding site [chemical binding]; other site 412418002181 Mg binding site [ion binding]; other site 412418002182 putative protofilament interaction site [polypeptide binding]; other site 412418002183 RodZ interaction site [polypeptide binding]; other site 412418002184 rod shape-determining protein MreC; Region: mreC; TIGR00219 412418002185 rod shape-determining protein MreC; Region: MreC; pfam04085 412418002186 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 412418002187 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412418002188 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 412418002189 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 412418002190 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 412418002191 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 412418002192 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 412418002193 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 412418002194 active site 412418002195 dimer interface [polypeptide binding]; other site 412418002196 motif 1; other site 412418002197 motif 2; other site 412418002198 motif 3; other site 412418002199 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 412418002200 anticodon binding site; other site 412418002201 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 412418002202 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 412418002203 putative active site; other site 412418002204 putative metal binding residues [ion binding]; other site 412418002205 signature motif; other site 412418002206 putative triphosphate binding site [ion binding]; other site 412418002207 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 412418002208 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 412418002209 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 412418002210 TrkA-N domain; Region: TrkA_N; pfam02254 412418002211 TrkA-C domain; Region: TrkA_C; pfam02080 412418002212 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 412418002213 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 412418002214 P-loop; other site 412418002215 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 412418002216 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 412418002217 active site 412418002218 ADP/pyrophosphate binding site [chemical binding]; other site 412418002219 dimerization interface [polypeptide binding]; other site 412418002220 allosteric effector site; other site 412418002221 fructose-1,6-bisphosphate binding site; other site 412418002222 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 412418002223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412418002224 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412418002225 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 412418002226 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 412418002227 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 412418002228 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 412418002229 active site 412418002230 dimer interface [polypeptide binding]; other site 412418002231 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 412418002232 dimer interface [polypeptide binding]; other site 412418002233 active site 412418002234 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 412418002235 ParB-like nuclease domain; Region: ParB; smart00470 412418002236 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 412418002237 Transglycosylase; Region: Transgly; pfam00912 412418002238 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 412418002239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 412418002240 TPR motif; other site 412418002241 binding surface 412418002242 Tetratricopeptide repeat; Region: TPR_12; pfam13424 412418002243 TPR repeat; Region: TPR_11; pfam13414 412418002244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412418002245 binding surface 412418002246 TPR motif; other site 412418002247 TPR repeat; Region: TPR_11; pfam13414 412418002248 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 412418002249 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 412418002250 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 412418002251 rare lipoprotein A; Region: rlpA; TIGR00413 412418002252 Sporulation related domain; Region: SPOR; pfam05036 412418002253 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 412418002254 DEAD/DEAH box helicase; Region: DEAD; pfam00270 412418002255 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 412418002256 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 412418002257 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 412418002258 FMN binding site [chemical binding]; other site 412418002259 active site 412418002260 catalytic residues [active] 412418002261 substrate binding site [chemical binding]; other site 412418002262 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 412418002263 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412418002264 active site 412418002265 HIGH motif; other site 412418002266 nucleotide binding site [chemical binding]; other site 412418002267 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412418002268 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 412418002269 active site 412418002270 KMSKS motif; other site 412418002271 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 412418002272 tRNA binding surface [nucleotide binding]; other site 412418002273 anticodon binding site; other site 412418002274 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 412418002275 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 412418002276 oligomerisation interface [polypeptide binding]; other site 412418002277 mobile loop; other site 412418002278 roof hairpin; other site 412418002279 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 412418002280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418002281 Walker A/P-loop; other site 412418002282 ATP binding site [chemical binding]; other site 412418002283 Q-loop/lid; other site 412418002284 ABC transporter signature motif; other site 412418002285 Walker B; other site 412418002286 D-loop; other site 412418002287 H-loop/switch region; other site 412418002288 ABC transporter; Region: ABC_tran_2; pfam12848 412418002289 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 412418002290 PQQ-like domain; Region: PQQ_2; pfam13360 412418002291 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 412418002292 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 412418002293 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 412418002294 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 412418002295 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 412418002296 minor groove reading motif; other site 412418002297 helix-hairpin-helix signature motif; other site 412418002298 substrate binding pocket [chemical binding]; other site 412418002299 active site 412418002300 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 412418002301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412418002302 dimer interface [polypeptide binding]; other site 412418002303 conserved gate region; other site 412418002304 ABC-ATPase subunit interface; other site 412418002305 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 412418002306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 412418002307 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 412418002308 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 412418002309 Protein of unknown function (DUF917); Region: DUF917; cl17829 412418002310 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 412418002311 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412418002312 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 412418002313 Walker A/P-loop; other site 412418002314 ATP binding site [chemical binding]; other site 412418002315 Q-loop/lid; other site 412418002316 ABC transporter signature motif; other site 412418002317 Walker B; other site 412418002318 D-loop; other site 412418002319 H-loop/switch region; other site 412418002320 ribonuclease Z; Region: RNase_Z; TIGR02651 412418002321 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 412418002322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 412418002323 ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512 412418002324 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 412418002325 oligomer interface [polypeptide binding]; other site 412418002326 active site residues [active] 412418002327 Domain of unknown function (DUF368); Region: DUF368; cl00893 412418002328 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 412418002329 putative metal binding site [ion binding]; other site 412418002330 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 412418002331 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 412418002332 Peptidase family M23; Region: Peptidase_M23; pfam01551 412418002333 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 412418002334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412418002335 active site 412418002336 phosphorylation site [posttranslational modification] 412418002337 intermolecular recognition site; other site 412418002338 dimerization interface [polypeptide binding]; other site 412418002339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412418002340 Walker A motif; other site 412418002341 ATP binding site [chemical binding]; other site 412418002342 Walker B motif; other site 412418002343 arginine finger; other site 412418002344 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 412418002345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412418002346 dimer interface [polypeptide binding]; other site 412418002347 phosphorylation site [posttranslational modification] 412418002348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412418002349 ATP binding site [chemical binding]; other site 412418002350 Mg2+ binding site [ion binding]; other site 412418002351 G-X-G motif; other site 412418002352 DNA polymerase III subunit delta'; Validated; Region: PRK08485 412418002353 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 412418002354 Colicin V production protein; Region: Colicin_V; pfam02674 412418002355 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 412418002356 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 412418002357 homodimer interface [polypeptide binding]; other site 412418002358 active site 412418002359 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 412418002360 substrate binding site [chemical binding]; other site 412418002361 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412418002362 ATP binding site [chemical binding]; other site 412418002363 UGMP family protein; Validated; Region: PRK09604 412418002364 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 412418002365 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 412418002366 NodB motif; other site 412418002367 putative active site [active] 412418002368 putative catalytic site [active] 412418002369 Zn binding site [ion binding]; other site 412418002370 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 412418002371 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 412418002372 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412418002373 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412418002374 DNA binding residues [nucleotide binding] 412418002375 Rod binding protein; Region: Rod-binding; cl01626 412418002376 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK12706 412418002377 Flagellar basal-body P-ring protein [Cell motility and secretion]; Region: FlgI; COG1706 412418002378 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 412418002379 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 412418002380 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 412418002381 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 412418002382 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 412418002383 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 412418002384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 412418002385 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412418002386 active site 412418002387 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 412418002388 hypothetical protein; Provisional; Region: PRK14553 412418002389 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 412418002390 GTPase CgtA; Reviewed; Region: obgE; PRK12299 412418002391 GTP1/OBG; Region: GTP1_OBG; pfam01018 412418002392 Obg GTPase; Region: Obg; cd01898 412418002393 G1 box; other site 412418002394 GTP/Mg2+ binding site [chemical binding]; other site 412418002395 Switch I region; other site 412418002396 G2 box; other site 412418002397 G3 box; other site 412418002398 Switch II region; other site 412418002399 G4 box; other site 412418002400 G5 box; other site 412418002401 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 412418002402 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 412418002403 active site 412418002404 (T/H)XGH motif; other site 412418002405 Transcriptional regulator [Transcription]; Region: LytR; COG1316 412418002406 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 412418002407 Oligomerisation domain; Region: Oligomerisation; cl00519 412418002408 regulatory protein SpoVG; Reviewed; Region: PRK13259 412418002409 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 412418002410 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 412418002411 5S rRNA interface [nucleotide binding]; other site 412418002412 CTC domain interface [polypeptide binding]; other site 412418002413 L16 interface [polypeptide binding]; other site 412418002414 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 412418002415 putative active site [active] 412418002416 catalytic residue [active] 412418002417 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 412418002418 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 412418002419 Ligand Binding Site [chemical binding]; other site 412418002420 FtsH Extracellular; Region: FtsH_ext; pfam06480 412418002421 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 412418002422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412418002423 Walker A motif; other site 412418002424 ATP binding site [chemical binding]; other site 412418002425 Walker B motif; other site 412418002426 arginine finger; other site 412418002427 Peptidase family M41; Region: Peptidase_M41; pfam01434 412418002428 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 412418002429 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 412418002430 protein binding site [polypeptide binding]; other site 412418002431 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 412418002432 thymidylate kinase; Region: DTMP_kinase; TIGR00041 412418002433 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 412418002434 TMP-binding site; other site 412418002435 ATP-binding site [chemical binding]; other site 412418002436 Family of unknown function (DUF490); Region: DUF490; pfam04357 412418002437 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 412418002438 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412418002439 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412418002440 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412418002441 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412418002442 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 412418002443 Surface antigen; Region: Bac_surface_Ag; pfam01103 412418002444 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 412418002445 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 412418002446 anti sigma factor interaction site; other site 412418002447 regulatory phosphorylation site [posttranslational modification]; other site 412418002448 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 412418002449 MutS domain I; Region: MutS_I; pfam01624 412418002450 MutS domain II; Region: MutS_II; pfam05188 412418002451 MutS domain III; Region: MutS_III; pfam05192 412418002452 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 412418002453 Walker A/P-loop; other site 412418002454 ATP binding site [chemical binding]; other site 412418002455 Q-loop/lid; other site 412418002456 ABC transporter signature motif; other site 412418002457 Walker B; other site 412418002458 D-loop; other site 412418002459 H-loop/switch region; other site 412418002460 hypothetical protein; Provisional; Region: PRK14630 412418002461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 412418002462 heptamer interface [polypeptide binding]; other site 412418002463 Sm1 motif; other site 412418002464 hexamer interface [polypeptide binding]; other site 412418002465 RNA binding site [nucleotide binding]; other site 412418002466 Sm2 motif; other site 412418002467 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 412418002468 NusA N-terminal domain; Region: NusA_N; pfam08529 412418002469 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 412418002470 RNA binding site [nucleotide binding]; other site 412418002471 homodimer interface [polypeptide binding]; other site 412418002472 NusA-like KH domain; Region: KH_5; pfam13184 412418002473 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 412418002474 G-X-X-G motif; other site 412418002475 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 412418002476 translation initiation factor IF-2; Region: IF-2; TIGR00487 412418002477 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 412418002478 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 412418002479 G1 box; other site 412418002480 putative GEF interaction site [polypeptide binding]; other site 412418002481 GTP/Mg2+ binding site [chemical binding]; other site 412418002482 Switch I region; other site 412418002483 G2 box; other site 412418002484 G3 box; other site 412418002485 Switch II region; other site 412418002486 G4 box; other site 412418002487 G5 box; other site 412418002488 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 412418002489 Translation-initiation factor 2; Region: IF-2; pfam11987 412418002490 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 412418002491 ribosome-binding factor A; Region: rbfA; TIGR00082 412418002492 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 412418002493 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 412418002494 RNA binding site [nucleotide binding]; other site 412418002495 active site 412418002496 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 412418002497 16S/18S rRNA binding site [nucleotide binding]; other site 412418002498 S13e-L30e interaction site [polypeptide binding]; other site 412418002499 25S rRNA binding site [nucleotide binding]; other site 412418002500 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 412418002501 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 412418002502 RNase E interface [polypeptide binding]; other site 412418002503 trimer interface [polypeptide binding]; other site 412418002504 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 412418002505 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 412418002506 RNase E interface [polypeptide binding]; other site 412418002507 trimer interface [polypeptide binding]; other site 412418002508 active site 412418002509 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 412418002510 putative nucleic acid binding region [nucleotide binding]; other site 412418002511 G-X-X-G motif; other site 412418002512 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 412418002513 RNA binding site [nucleotide binding]; other site 412418002514 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 412418002515 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 412418002516 Predicted permeases [General function prediction only]; Region: COG0795 412418002517 Predicted permeases [General function prediction only]; Region: COG0795 412418002518 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 412418002519 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 412418002520 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 412418002521 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 412418002522 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 412418002523 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 412418002524 Flavoprotein; Region: Flavoprotein; pfam02441 412418002525 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 412418002526 sodium/panthothenate symporter; Provisional; Region: panF; PRK09442 412418002527 Na binding site [ion binding]; other site 412418002528 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 412418002529 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 412418002530 active site 412418002531 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 412418002532 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412418002533 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412418002534 Influenza RNA-dependent RNA polymerase subunit PB1; Region: Flu_PB1; pfam00602 412418002535 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412418002536 TIGR00255 family protein; Region: TIGR00255 412418002537 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 412418002538 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 412418002539 cytidylate kinase; Provisional; Region: PRK04182 412418002540 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 412418002541 CMP-binding site; other site 412418002542 The sites determining sugar specificity; other site 412418002543 tRNA delta(2)-isopentenylpyrophosphate transferase; Provisional; Region: miaA; PRK14729 412418002544 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 412418002545 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 412418002546 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 412418002547 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 412418002548 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 412418002549 active site turn [active] 412418002550 phosphorylation site [posttranslational modification] 412418002551 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 412418002552 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412418002553 ATP binding site [chemical binding]; other site 412418002554 putative Mg++ binding site [ion binding]; other site 412418002555 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412418002556 nucleotide binding region [chemical binding]; other site 412418002557 ATP-binding site [chemical binding]; other site 412418002558 Helicase associated domain (HA2); Region: HA2; pfam04408 412418002559 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 412418002560 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 412418002561 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 412418002562 active site 412418002563 interdomain interaction site; other site 412418002564 putative metal-binding site [ion binding]; other site 412418002565 nucleotide binding site [chemical binding]; other site 412418002566 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 412418002567 domain I; other site 412418002568 phosphate binding site [ion binding]; other site 412418002569 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 412418002570 domain II; other site 412418002571 domain III; other site 412418002572 nucleotide binding site [chemical binding]; other site 412418002573 DNA binding groove [nucleotide binding] 412418002574 catalytic site [active] 412418002575 domain IV; other site 412418002576 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 412418002577 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 412418002578 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 412418002579 active site 412418002580 metal binding site [ion binding]; metal-binding site 412418002581 DNA binding site [nucleotide binding] 412418002582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418002583 AAA domain; Region: AAA_23; pfam13476 412418002584 Walker A/P-loop; other site 412418002585 ATP binding site [chemical binding]; other site 412418002586 Q-loop/lid; other site 412418002587 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 412418002588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 412418002589 Q-loop/lid; other site 412418002590 ABC transporter signature motif; other site 412418002591 Walker B; other site 412418002592 D-loop; other site 412418002593 H-loop/switch region; other site 412418002594 CutC family; Region: CutC; cl01218 412418002595 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 412418002596 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 412418002597 HIGH motif; other site 412418002598 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 412418002599 active site 412418002600 KMSKS motif; other site 412418002601 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 412418002602 tRNA binding surface [nucleotide binding]; other site 412418002603 anticodon binding site; other site 412418002604 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 412418002605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412418002606 Walker A motif; other site 412418002607 ATP binding site [chemical binding]; other site 412418002608 Walker B motif; other site 412418002609 arginine finger; other site 412418002610 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 412418002611 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 412418002612 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 412418002613 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 412418002614 active site 412418002615 substrate binding site [chemical binding]; other site 412418002616 metal binding site [ion binding]; metal-binding site 412418002617 excinuclease ABC subunit B; Provisional; Region: PRK05298 412418002618 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412418002619 ATP binding site [chemical binding]; other site 412418002620 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412418002621 nucleotide binding region [chemical binding]; other site 412418002622 ATP-binding site [chemical binding]; other site 412418002623 Ultra-violet resistance protein B; Region: UvrB; pfam12344 412418002624 UvrB/uvrC motif; Region: UVR; pfam02151 412418002625 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 412418002626 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 412418002627 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 412418002628 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 412418002629 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 412418002630 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 412418002631 active site 412418002632 arginine deiminase; Provisional; Region: PRK01388 412418002633 ornithine carbamoyltransferase; Provisional; Region: PRK04284 412418002634 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 412418002635 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 412418002636 Predicted membrane protein [Function unknown]; Region: COG1288 412418002637 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 412418002638 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 412418002639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 412418002640 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 412418002641 Probable transposase; Region: OrfB_IS605; pfam01385 412418002642 Transposase IS200 like; Region: Y1_Tnp; pfam01797 412418002643 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 412418002644 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 412418002645 dimer interface [polypeptide binding]; other site 412418002646 putative radical transfer pathway; other site 412418002647 diiron center [ion binding]; other site 412418002648 tyrosyl radical; other site 412418002649 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 412418002650 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 412418002651 Class I ribonucleotide reductase; Region: RNR_I; cd01679 412418002652 active site 412418002653 dimer interface [polypeptide binding]; other site 412418002654 catalytic residues [active] 412418002655 effector binding site; other site 412418002656 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 412418002657 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972 412418002658 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 412418002659 Borrelia burgdorferi protein of unknown function (DUF777); Region: DUF777; pfam05606 412418002660 Borrelia burgdorferi protein of unknown function (DUF792); Region: DUF792; pfam05632 412418002661 Protein of unknown function (DUF1322); Region: DUF1322; pfam07032 412418002662 Protein of unknown function (DUF1473); Region: DUF1473; pfam07341 412418002663 Protein of unknown function (DUF1463); Region: DUF1463; pfam07316 412418002664 Borrelia burgdorferi protein of unknown function (DUF787); Region: DUF787; pfam05619 412418002665 Borrelia burgdorferi protein of unknown function (DUF764); Region: DUF764; pfam05561 412418002666 Domain of unknown function (DUF3890); Region: DUF3890; pfam13029 412418002667 Phage terminase large subunit; Region: Terminase_3; cl12054 412418002668 Terminase-like family; Region: Terminase_6; pfam03237 412418002669 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 412418002670 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412418002671 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002672 P-loop; other site 412418002673 Magnesium ion binding site [ion binding]; other site 412418002674 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002675 Magnesium ion binding site [ion binding]; other site 412418002676 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 412418002677 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 412418002678 Borrelia orf-D family; Region: Borrelia_orfD; pfam02999 412418002679 Borrelia hemolysin accessory protein; Region: BLYB; pfam05289 412418002680 Protein of unknown function (DUF685); Region: DUF685; pfam05085 412418002681 DUF276; Region: DUF276; pfam03434 412418002682 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 412418002683 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 412418002684 Isochorismatase family; Region: Isochorismatase; pfam00857 412418002685 catalytic triad [active] 412418002686 metal binding site [ion binding]; metal-binding site 412418002687 conserved cis-peptide bond; other site 412418002688 GMP synthase; Reviewed; Region: guaA; PRK00074 412418002689 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 412418002690 AMP/PPi binding site [chemical binding]; other site 412418002691 candidate oxyanion hole; other site 412418002692 catalytic triad [active] 412418002693 potential glutamine specificity residues [chemical binding]; other site 412418002694 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 412418002695 ATP Binding subdomain [chemical binding]; other site 412418002696 Ligand Binding sites [chemical binding]; other site 412418002697 Dimerization subdomain; other site 412418002698 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 412418002699 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 412418002700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 412418002701 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 412418002702 active site 412418002703 Permease family; Region: Xan_ur_permease; pfam00860 412418002704 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 412418002705 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 412418002706 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 412418002707 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 412418002708 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 412418002709 active site turn [active] 412418002710 phosphorylation site [posttranslational modification] 412418002711 acylphosphatase; Provisional; Region: PRK14432 412418002712 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 412418002713 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 412418002714 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412418002715 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002716 P-loop; other site 412418002717 Magnesium ion binding site [ion binding]; other site 412418002718 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002719 Magnesium ion binding site [ion binding]; other site 412418002720 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 412418002721 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002722 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 412418002723 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 412418002724 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412418002725 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002726 P-loop; other site 412418002727 Magnesium ion binding site [ion binding]; other site 412418002728 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002729 Magnesium ion binding site [ion binding]; other site 412418002730 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 412418002731 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002732 Haemagglutinin; Region: Hemagglutinin; pfam00509 412418002733 Lipoprotein; Region: Lipoprotein_6; pfam01441 412418002734 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002735 Lipoprotein; Region: Lipoprotein_6; pfam01441 412418002736 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002737 Mlp lipoprotein family; Region: Mlp; pfam03304 412418002738 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 412418002739 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412418002740 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002741 P-loop; other site 412418002742 Magnesium ion binding site [ion binding]; other site 412418002743 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002744 Magnesium ion binding site [ion binding]; other site 412418002745 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 412418002746 Mlp lipoprotein family; Region: Mlp; pfam03304 412418002747 Protein of unknown function, DUF603; Region: DUF603; pfam04645 412418002748 Lipoprotein; Region: Lipoprotein_6; pfam01441 412418002749 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002750 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 412418002751 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 412418002752 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002753 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002754 phosphodiesterase; Provisional; Region: PRK12704 412418002755 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412418002756 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002757 P-loop; other site 412418002758 Magnesium ion binding site [ion binding]; other site 412418002759 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002760 Magnesium ion binding site [ion binding]; other site 412418002761 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 412418002762 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002763 Lipoprotein; Region: Lipoprotein_6; pfam01441 412418002764 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002765 Lipoprotein; Region: Lipoprotein_6; pfam01441 412418002766 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002767 Lipoprotein; Region: Lipoprotein_6; pfam01441 412418002768 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 412418002769 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412418002770 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002771 P-loop; other site 412418002772 Magnesium ion binding site [ion binding]; other site 412418002773 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002774 Magnesium ion binding site [ion binding]; other site 412418002775 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 412418002776 Lipoprotein; Region: Lipoprotein_6; pfam01441 412418002777 Protein of unknown function, DUF603; Region: DUF603; pfam04645 412418002778 Putative plasmid partition protein; Region: Plasmid_parti; pfam01672 412418002779 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412418002780 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002781 P-loop; other site 412418002782 Magnesium ion binding site [ion binding]; other site 412418002783 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002784 Magnesium ion binding site [ion binding]; other site 412418002785 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 412418002786 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414 412418002787 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 412418002788 active site 412418002789 Int/Topo IB signature motif; other site 412418002790 catalytic residues [active] 412418002791 DNA binding site [nucleotide binding] 412418002792 Mlp lipoprotein family; Region: Mlp; pfam03304 412418002793 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002794 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002795 phosphodiesterase; Provisional; Region: PRK12704 412418002796 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412418002797 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002798 P-loop; other site 412418002799 Magnesium ion binding site [ion binding]; other site 412418002800 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002801 Magnesium ion binding site [ion binding]; other site 412418002802 Borrelia family of unknown function DUF226; Region: DUF226; pfam02890 412418002803 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002804 Lipoprotein; Region: Lipoprotein_6; pfam01441 412418002805 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002806 Lipoprotein; Region: Lipoprotein_6; pfam01441 412418002807 Borrelia lipoprotein; Region: Lipoprotein_2; pfam00921 412418002808 Lipoprotein; Region: Lipoprotein_6; pfam01441 412418002809 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 412418002810 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002811 P-loop; other site 412418002812 Magnesium ion binding site [ion binding]; other site 412418002813 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 412418002814 Magnesium ion binding site [ion binding]; other site 412418002815 Borrelia ORF-A; Region: Borrelia_orfA; pfam02414