-- dump date 20140619_004950 -- class Genbank::misc_feature -- table misc_feature_note -- id note 446465000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 446465000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465000003 Walker A motif; other site 446465000004 ATP binding site [chemical binding]; other site 446465000005 Walker B motif; other site 446465000006 arginine finger; other site 446465000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 446465000008 DnaA box-binding interface [nucleotide binding]; other site 446465000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 446465000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 446465000011 putative DNA binding surface [nucleotide binding]; other site 446465000012 dimer interface [polypeptide binding]; other site 446465000013 beta-clamp/clamp loader binding surface; other site 446465000014 beta-clamp/translesion DNA polymerase binding surface; other site 446465000015 recombination protein F; Reviewed; Region: recF; PRK00064 446465000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 446465000017 Walker A/P-loop; other site 446465000018 ATP binding site [chemical binding]; other site 446465000019 Q-loop/lid; other site 446465000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465000021 ABC transporter signature motif; other site 446465000022 Walker B; other site 446465000023 D-loop; other site 446465000024 H-loop/switch region; other site 446465000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 446465000026 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 446465000027 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 446465000028 catalytic motif [active] 446465000029 Zn binding site [ion binding]; other site 446465000030 RibD C-terminal domain; Region: RibD_C; pfam01872 446465000031 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 446465000032 Lumazine binding domain; Region: Lum_binding; pfam00677 446465000033 Lumazine binding domain; Region: Lum_binding; pfam00677 446465000034 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 446465000035 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 446465000036 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 446465000037 dimerization interface [polypeptide binding]; other site 446465000038 active site 446465000039 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 446465000040 homopentamer interface [polypeptide binding]; other site 446465000041 active site 446465000042 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 446465000043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465000044 Mg2+ binding site [ion binding]; other site 446465000045 G-X-G motif; other site 446465000046 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 446465000047 anchoring element; other site 446465000048 dimer interface [polypeptide binding]; other site 446465000049 ATP binding site [chemical binding]; other site 446465000050 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 446465000051 active site 446465000052 putative metal-binding site [ion binding]; other site 446465000053 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446465000054 DNA gyrase subunit A; Validated; Region: PRK05560 446465000055 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 446465000056 CAP-like domain; other site 446465000057 active site 446465000058 primary dimer interface [polypeptide binding]; other site 446465000059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446465000060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446465000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446465000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446465000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446465000064 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 446465000065 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 446465000066 putative deacylase active site [active] 446465000067 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 446465000068 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 446465000069 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446465000070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446465000071 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 446465000072 short chain dehydrogenase; Provisional; Region: PRK08219 446465000073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000074 NAD(P) binding site [chemical binding]; other site 446465000075 active site 446465000076 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446465000077 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446465000078 DNA binding residues [nucleotide binding] 446465000079 Ferredoxin [Energy production and conversion]; Region: COG1146 446465000080 4Fe-4S binding domain; Region: Fer4; pfam00037 446465000081 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 446465000082 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446465000083 DNA binding residues [nucleotide binding] 446465000084 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 446465000085 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 446465000086 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 446465000087 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446465000088 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 446465000089 Walker A/P-loop; other site 446465000090 ATP binding site [chemical binding]; other site 446465000091 Q-loop/lid; other site 446465000092 ABC transporter signature motif; other site 446465000093 Walker B; other site 446465000094 D-loop; other site 446465000095 H-loop/switch region; other site 446465000096 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446465000097 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446465000098 FtsX-like permease family; Region: FtsX; pfam02687 446465000099 Histidine kinase; Region: HisKA_3; pfam07730 446465000100 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446465000101 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465000102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465000103 active site 446465000104 phosphorylation site [posttranslational modification] 446465000105 intermolecular recognition site; other site 446465000106 dimerization interface [polypeptide binding]; other site 446465000107 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446465000108 DNA binding residues [nucleotide binding] 446465000109 dimerization interface [polypeptide binding]; other site 446465000110 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 446465000111 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 446465000112 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 446465000113 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 446465000114 active site 446465000115 multimer interface [polypeptide binding]; other site 446465000116 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 446465000117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465000118 DNA-binding site [nucleotide binding]; DNA binding site 446465000119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465000120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465000121 homodimer interface [polypeptide binding]; other site 446465000122 catalytic residue [active] 446465000123 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 446465000124 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446465000125 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 446465000126 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000127 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465000128 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465000129 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465000130 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000131 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465000132 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446465000133 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 446465000134 putative DNA binding site [nucleotide binding]; other site 446465000135 putative Zn2+ binding site [ion binding]; other site 446465000136 AsnC family; Region: AsnC_trans_reg; pfam01037 446465000137 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 446465000138 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446465000139 TPP-binding site [chemical binding]; other site 446465000140 tetramer interface [polypeptide binding]; other site 446465000141 heterodimer interface [polypeptide binding]; other site 446465000142 phosphorylation loop region [posttranslational modification] 446465000143 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446465000144 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446465000145 alpha subunit interface [polypeptide binding]; other site 446465000146 TPP binding site [chemical binding]; other site 446465000147 heterodimer interface [polypeptide binding]; other site 446465000148 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446465000149 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446465000150 E3 interaction surface; other site 446465000151 lipoyl attachment site [posttranslational modification]; other site 446465000152 e3 binding domain; Region: E3_binding; pfam02817 446465000153 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 446465000154 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446465000155 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 446465000156 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 446465000157 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446465000158 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446465000159 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 446465000160 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446465000161 carboxyltransferase (CT) interaction site; other site 446465000162 biotinylation site [posttranslational modification]; other site 446465000163 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 446465000164 putative active site [active] 446465000165 putative catalytic site [active] 446465000166 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 446465000167 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446465000168 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446465000169 active site 446465000170 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446465000171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465000172 DNA-binding site [nucleotide binding]; DNA binding site 446465000173 FCD domain; Region: FCD; pfam07729 446465000174 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446465000175 nucleoside/Zn binding site; other site 446465000176 dimer interface [polypeptide binding]; other site 446465000177 catalytic motif [active] 446465000178 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 446465000179 substrate binding site [chemical binding]; other site 446465000180 dimer interface [polypeptide binding]; other site 446465000181 catalytic triad [active] 446465000182 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 446465000183 dihydroxyacetone kinase; Provisional; Region: PRK14479 446465000184 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 446465000185 DAK2 domain; Region: Dak2; pfam02734 446465000186 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 446465000187 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465000188 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446465000189 classical (c) SDRs; Region: SDR_c; cd05233 446465000190 NAD(P) binding site [chemical binding]; other site 446465000191 active site 446465000192 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 446465000193 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446465000194 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446465000195 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 446465000196 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446465000197 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 446465000198 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446465000199 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446465000200 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446465000201 classical (c) SDRs; Region: SDR_c; cd05233 446465000202 NAD(P) binding site [chemical binding]; other site 446465000203 active site 446465000204 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 446465000205 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 446465000206 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446465000207 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 446465000208 metal binding site [ion binding]; metal-binding site 446465000209 substrate binding pocket [chemical binding]; other site 446465000210 Domain of unknown function (DUF718); Region: DUF718; pfam05336 446465000211 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465000212 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465000213 active site 446465000214 catalytic tetrad [active] 446465000215 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 446465000216 Amidohydrolase; Region: Amidohydro_2; pfam04909 446465000217 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465000218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465000219 DNA-binding site [nucleotide binding]; DNA binding site 446465000220 FCD domain; Region: FCD; pfam07729 446465000221 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 446465000222 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000224 dimer interface [polypeptide binding]; other site 446465000225 conserved gate region; other site 446465000226 putative PBP binding loops; other site 446465000227 ABC-ATPase subunit interface; other site 446465000228 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465000229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000230 ABC-ATPase subunit interface; other site 446465000231 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 446465000232 peptide binding site [polypeptide binding]; other site 446465000233 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465000234 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446465000235 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465000236 Walker A/P-loop; other site 446465000237 ATP binding site [chemical binding]; other site 446465000238 Q-loop/lid; other site 446465000239 ABC transporter signature motif; other site 446465000240 Walker B; other site 446465000241 D-loop; other site 446465000242 H-loop/switch region; other site 446465000243 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465000244 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465000245 Walker A/P-loop; other site 446465000246 ATP binding site [chemical binding]; other site 446465000247 Q-loop/lid; other site 446465000248 ABC transporter signature motif; other site 446465000249 Walker B; other site 446465000250 D-loop; other site 446465000251 H-loop/switch region; other site 446465000252 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446465000253 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446465000254 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465000255 DNA-binding site [nucleotide binding]; DNA binding site 446465000256 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 446465000257 Uncharacterized conserved protein [Function unknown]; Region: COG5476 446465000258 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 446465000259 MlrC C-terminus; Region: MlrC_C; pfam07171 446465000260 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 446465000261 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 446465000262 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465000263 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465000264 active site 446465000265 catalytic tetrad [active] 446465000266 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 446465000267 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 446465000268 NAD binding site [chemical binding]; other site 446465000269 sugar binding site [chemical binding]; other site 446465000270 divalent metal binding site [ion binding]; other site 446465000271 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446465000272 dimer interface [polypeptide binding]; other site 446465000273 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465000274 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465000275 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465000276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000277 dimer interface [polypeptide binding]; other site 446465000278 conserved gate region; other site 446465000279 putative PBP binding loops; other site 446465000280 ABC-ATPase subunit interface; other site 446465000281 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465000282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000283 dimer interface [polypeptide binding]; other site 446465000284 conserved gate region; other site 446465000285 putative PBP binding loops; other site 446465000286 ABC-ATPase subunit interface; other site 446465000287 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446465000288 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446465000289 substrate binding site [chemical binding]; other site 446465000290 ATP binding site [chemical binding]; other site 446465000291 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 446465000292 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 446465000293 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 446465000294 putative hydrophobic ligand binding site [chemical binding]; other site 446465000295 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 446465000296 RibD C-terminal domain; Region: RibD_C; cl17279 446465000297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465000298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465000299 WHG domain; Region: WHG; pfam13305 446465000300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465000301 S-adenosylmethionine binding site [chemical binding]; other site 446465000302 HNH endonuclease; Region: HNH_2; pfam13391 446465000303 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 446465000304 Na binding site [ion binding]; other site 446465000305 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446465000306 nucleoside/Zn binding site; other site 446465000307 dimer interface [polypeptide binding]; other site 446465000308 catalytic motif [active] 446465000309 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446465000310 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446465000311 TM-ABC transporter signature motif; other site 446465000312 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446465000313 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446465000314 TM-ABC transporter signature motif; other site 446465000315 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446465000316 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446465000317 Walker A/P-loop; other site 446465000318 ATP binding site [chemical binding]; other site 446465000319 Q-loop/lid; other site 446465000320 ABC transporter signature motif; other site 446465000321 Walker B; other site 446465000322 D-loop; other site 446465000323 H-loop/switch region; other site 446465000324 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446465000325 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465000326 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 446465000327 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446465000328 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446465000329 Walker A/P-loop; other site 446465000330 ATP binding site [chemical binding]; other site 446465000331 Q-loop/lid; other site 446465000332 ABC transporter signature motif; other site 446465000333 Walker B; other site 446465000334 D-loop; other site 446465000335 H-loop/switch region; other site 446465000336 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446465000337 ABC transporter; Region: ABC_tran; pfam00005 446465000338 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465000339 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465000340 DNA binding site [nucleotide binding] 446465000341 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446465000342 ligand binding site [chemical binding]; other site 446465000343 dimerization interface (open form) [polypeptide binding]; other site 446465000344 dimerization interface (closed form) [polypeptide binding]; other site 446465000345 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 446465000346 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 446465000347 active site 446465000348 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 446465000349 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446465000350 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 446465000351 active site 446465000352 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465000353 Sulfatase; Region: Sulfatase; pfam00884 446465000354 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465000355 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465000356 active site 446465000357 catalytic tetrad [active] 446465000358 Sulfatase; Region: Sulfatase; cl17466 446465000359 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465000360 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 446465000361 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465000362 catalytic core [active] 446465000363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446465000364 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 446465000365 dimer interface [polypeptide binding]; other site 446465000366 putative metal binding site [ion binding]; other site 446465000367 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 446465000368 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 446465000369 DAK2 domain; Region: Dak2; pfam02734 446465000370 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000371 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465000372 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465000373 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000374 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465000375 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465000376 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465000377 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465000378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000379 dimer interface [polypeptide binding]; other site 446465000380 conserved gate region; other site 446465000381 putative PBP binding loops; other site 446465000382 ABC-ATPase subunit interface; other site 446465000383 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 446465000384 MarR family; Region: MarR_2; pfam12802 446465000385 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446465000386 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465000387 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446465000388 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446465000389 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465000390 putative DNA binding site [nucleotide binding]; other site 446465000391 putative Zn2+ binding site [ion binding]; other site 446465000392 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465000393 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465000394 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446465000395 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446465000396 substrate binding site [chemical binding]; other site 446465000397 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465000398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000399 dimer interface [polypeptide binding]; other site 446465000400 conserved gate region; other site 446465000401 putative PBP binding loops; other site 446465000402 ABC-ATPase subunit interface; other site 446465000403 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465000404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000405 dimer interface [polypeptide binding]; other site 446465000406 conserved gate region; other site 446465000407 putative PBP binding loops; other site 446465000408 ABC-ATPase subunit interface; other site 446465000409 K+-transporting ATPase, c chain; Region: KdpC; cl00944 446465000410 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465000411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465000412 Walker A/P-loop; other site 446465000413 ATP binding site [chemical binding]; other site 446465000414 Q-loop/lid; other site 446465000415 ABC transporter signature motif; other site 446465000416 Walker B; other site 446465000417 D-loop; other site 446465000418 H-loop/switch region; other site 446465000419 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465000420 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465000421 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465000422 Walker A/P-loop; other site 446465000423 ATP binding site [chemical binding]; other site 446465000424 Q-loop/lid; other site 446465000425 ABC transporter signature motif; other site 446465000426 Walker B; other site 446465000427 D-loop; other site 446465000428 H-loop/switch region; other site 446465000429 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465000430 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 446465000431 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446465000432 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 446465000433 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 446465000434 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465000435 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465000436 dimerization interface [polypeptide binding]; other site 446465000437 ligand binding site [chemical binding]; other site 446465000438 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 446465000439 TrkA-C domain; Region: TrkA_C; pfam02080 446465000440 TrkA-C domain; Region: TrkA_C; pfam02080 446465000441 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 446465000442 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446465000443 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446465000444 Bacterial transcriptional regulator; Region: IclR; pfam01614 446465000445 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 446465000446 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446465000447 metal binding site [ion binding]; metal-binding site 446465000448 substrate binding pocket [chemical binding]; other site 446465000449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465000450 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446465000451 MarR family; Region: MarR; pfam01047 446465000452 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 446465000453 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446465000454 substrate binding site [chemical binding]; other site 446465000455 ATP binding site [chemical binding]; other site 446465000456 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 446465000457 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 446465000458 active site 446465000459 intersubunit interface [polypeptide binding]; other site 446465000460 catalytic residue [active] 446465000461 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 446465000462 MgtE intracellular N domain; Region: MgtE_N; pfam03448 446465000463 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 446465000464 Divalent cation transporter; Region: MgtE; pfam01769 446465000465 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465000466 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465000467 DNA binding site [nucleotide binding] 446465000468 domain linker motif; other site 446465000469 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465000470 dimerization interface [polypeptide binding]; other site 446465000471 ligand binding site [chemical binding]; other site 446465000472 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465000473 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446465000474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000475 dimer interface [polypeptide binding]; other site 446465000476 conserved gate region; other site 446465000477 putative PBP binding loops; other site 446465000478 ABC-ATPase subunit interface; other site 446465000479 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465000480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000481 dimer interface [polypeptide binding]; other site 446465000482 conserved gate region; other site 446465000483 putative PBP binding loops; other site 446465000484 ABC-ATPase subunit interface; other site 446465000485 putative alpha-glucosidase; Provisional; Region: PRK10658 446465000486 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 446465000487 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 446465000488 active site 446465000489 homotrimer interface [polypeptide binding]; other site 446465000490 catalytic site [active] 446465000491 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 446465000492 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446465000493 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465000494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000495 dimer interface [polypeptide binding]; other site 446465000496 conserved gate region; other site 446465000497 putative PBP binding loops; other site 446465000498 ABC-ATPase subunit interface; other site 446465000499 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 446465000500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000501 dimer interface [polypeptide binding]; other site 446465000502 conserved gate region; other site 446465000503 putative PBP binding loops; other site 446465000504 ABC-ATPase subunit interface; other site 446465000505 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465000506 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446465000507 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000508 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465000509 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465000510 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000511 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465000512 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446465000513 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000514 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465000515 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465000516 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446465000517 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446465000518 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446465000519 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446465000520 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 446465000521 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465000522 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465000523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000524 dimer interface [polypeptide binding]; other site 446465000525 conserved gate region; other site 446465000526 putative PBP binding loops; other site 446465000527 ABC-ATPase subunit interface; other site 446465000528 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465000529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000530 dimer interface [polypeptide binding]; other site 446465000531 conserved gate region; other site 446465000532 ABC-ATPase subunit interface; other site 446465000533 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 446465000534 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465000535 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465000536 DNA binding site [nucleotide binding] 446465000537 domain linker motif; other site 446465000538 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465000539 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465000540 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465000541 xylose isomerase; Provisional; Region: PRK12677 446465000542 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 446465000543 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465000544 nucleotide binding site [chemical binding]; other site 446465000545 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 446465000546 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 446465000547 ATP binding site [chemical binding]; other site 446465000548 substrate interface [chemical binding]; other site 446465000549 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446465000550 active site residue [active] 446465000551 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 446465000552 ThiS interaction site; other site 446465000553 putative active site [active] 446465000554 tetramer interface [polypeptide binding]; other site 446465000555 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 446465000556 thiS-thiF/thiG interaction site; other site 446465000557 hydroxyglutarate oxidase; Provisional; Region: PRK11728 446465000558 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 446465000559 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 446465000560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000561 NAD(P) binding site [chemical binding]; other site 446465000562 active site 446465000563 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 446465000564 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 446465000565 active site 446465000566 non-prolyl cis peptide bond; other site 446465000567 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465000568 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465000569 DNA binding site [nucleotide binding] 446465000570 domain linker motif; other site 446465000571 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465000572 dimerization interface [polypeptide binding]; other site 446465000573 ligand binding site [chemical binding]; other site 446465000574 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446465000575 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465000576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000577 dimer interface [polypeptide binding]; other site 446465000578 conserved gate region; other site 446465000579 putative PBP binding loops; other site 446465000580 ABC-ATPase subunit interface; other site 446465000581 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465000582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000583 dimer interface [polypeptide binding]; other site 446465000584 conserved gate region; other site 446465000585 putative PBP binding loops; other site 446465000586 ABC-ATPase subunit interface; other site 446465000587 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 446465000588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 446465000589 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446465000590 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 446465000591 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 446465000592 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 446465000593 Ca binding site [ion binding]; other site 446465000594 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000595 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465000596 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465000597 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 446465000598 Na binding site [ion binding]; other site 446465000599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465000600 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465000601 active site 446465000602 catalytic tetrad [active] 446465000603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465000604 putative substrate translocation pore; other site 446465000605 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 446465000606 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446465000607 MarR family; Region: MarR_2; pfam12802 446465000608 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465000609 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465000610 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000611 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465000612 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465000613 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465000614 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465000615 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465000616 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 446465000617 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 446465000618 putative active site [active] 446465000619 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 446465000620 nudix motif; other site 446465000621 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 446465000622 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446465000623 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 446465000624 metal binding site [ion binding]; metal-binding site 446465000625 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 446465000626 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 446465000627 putative ADP-binding pocket [chemical binding]; other site 446465000628 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446465000629 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 446465000630 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465000631 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465000632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465000633 Walker A/P-loop; other site 446465000634 ATP binding site [chemical binding]; other site 446465000635 Q-loop/lid; other site 446465000636 ABC transporter signature motif; other site 446465000637 Walker B; other site 446465000638 D-loop; other site 446465000639 H-loop/switch region; other site 446465000640 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446465000641 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446465000642 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 446465000643 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446465000644 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 446465000645 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 446465000646 Predicted membrane protein [Function unknown]; Region: COG1511 446465000647 Predicted membrane protein [Function unknown]; Region: COG1511 446465000648 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 446465000649 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 446465000650 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465000651 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 446465000652 active site 446465000653 HIGH motif; other site 446465000654 nucleotide binding site [chemical binding]; other site 446465000655 active site 446465000656 KMSKS motif; other site 446465000657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446465000658 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446465000659 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 446465000660 active site 446465000661 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446465000662 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 446465000663 Rhomboid family; Region: Rhomboid; pfam01694 446465000664 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 446465000665 putative substrate binding pocket [chemical binding]; other site 446465000666 AC domain interface; other site 446465000667 catalytic triad [active] 446465000668 AB domain interface; other site 446465000669 interchain disulfide; other site 446465000670 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446465000671 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465000672 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465000673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465000674 Walker A/P-loop; other site 446465000675 ATP binding site [chemical binding]; other site 446465000676 Q-loop/lid; other site 446465000677 ABC transporter signature motif; other site 446465000678 Walker B; other site 446465000679 D-loop; other site 446465000680 H-loop/switch region; other site 446465000681 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465000682 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465000683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465000684 Walker A/P-loop; other site 446465000685 ATP binding site [chemical binding]; other site 446465000686 Q-loop/lid; other site 446465000687 ABC transporter signature motif; other site 446465000688 Walker B; other site 446465000689 D-loop; other site 446465000690 H-loop/switch region; other site 446465000691 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 446465000692 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446465000693 active site 446465000694 catalytic site [active] 446465000695 Predicted esterase [General function prediction only]; Region: COG0627 446465000696 S-formylglutathione hydrolase; Region: PLN02442 446465000697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446465000698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446465000699 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446465000700 putative dimerization interface [polypeptide binding]; other site 446465000701 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465000702 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465000703 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446465000704 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446465000705 substrate binding pocket [chemical binding]; other site 446465000706 membrane-bound complex binding site; other site 446465000707 hinge residues; other site 446465000708 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446465000709 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446465000710 Walker A/P-loop; other site 446465000711 ATP binding site [chemical binding]; other site 446465000712 Q-loop/lid; other site 446465000713 ABC transporter signature motif; other site 446465000714 Walker B; other site 446465000715 D-loop; other site 446465000716 H-loop/switch region; other site 446465000717 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465000718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000719 dimer interface [polypeptide binding]; other site 446465000720 conserved gate region; other site 446465000721 putative PBP binding loops; other site 446465000722 ABC-ATPase subunit interface; other site 446465000723 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 446465000724 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 446465000725 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446465000726 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 446465000727 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446465000728 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 446465000729 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465000730 dimerization interface [polypeptide binding]; other site 446465000731 putative DNA binding site [nucleotide binding]; other site 446465000732 putative Zn2+ binding site [ion binding]; other site 446465000733 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 446465000734 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465000735 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465000736 active site 446465000737 catalytic tetrad [active] 446465000738 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446465000739 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446465000740 active site 446465000741 Methyltransferase domain; Region: Methyltransf_11; pfam08241 446465000742 Staphylococcal nuclease homologues; Region: SNc; smart00318 446465000743 Catalytic site; other site 446465000744 Staphylococcal nuclease homologue; Region: SNase; pfam00565 446465000745 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465000746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465000747 active site 446465000748 phosphorylation site [posttranslational modification] 446465000749 intermolecular recognition site; other site 446465000750 dimerization interface [polypeptide binding]; other site 446465000751 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446465000752 DNA binding residues [nucleotide binding] 446465000753 dimerization interface [polypeptide binding]; other site 446465000754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446465000755 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446465000756 CAAX protease self-immunity; Region: Abi; pfam02517 446465000757 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446465000758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446465000759 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446465000760 DNA binding residues [nucleotide binding] 446465000761 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465000762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465000763 Walker A/P-loop; other site 446465000764 ATP binding site [chemical binding]; other site 446465000765 Q-loop/lid; other site 446465000766 ABC transporter signature motif; other site 446465000767 Walker B; other site 446465000768 D-loop; other site 446465000769 H-loop/switch region; other site 446465000770 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446465000771 Beta-lactamase; Region: Beta-lactamase; pfam00144 446465000772 Domain of unknown function DUF21; Region: DUF21; pfam01595 446465000773 FOG: CBS domain [General function prediction only]; Region: COG0517 446465000774 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446465000775 Transporter associated domain; Region: CorC_HlyC; smart01091 446465000776 pyruvate dehydrogenase; Provisional; Region: PRK06546 446465000777 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 446465000778 PYR/PP interface [polypeptide binding]; other site 446465000779 dimer interface [polypeptide binding]; other site 446465000780 tetramer interface [polypeptide binding]; other site 446465000781 TPP binding site [chemical binding]; other site 446465000782 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446465000783 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 446465000784 TPP-binding site [chemical binding]; other site 446465000785 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 446465000786 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446465000787 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446465000788 Methylamine utilisation protein MauE; Region: MauE; pfam07291 446465000789 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 446465000790 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 446465000791 NAD(P) binding site [chemical binding]; other site 446465000792 catalytic residues [active] 446465000793 Peptidase family M48; Region: Peptidase_M48; pfam01435 446465000794 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446465000795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465000796 putative substrate translocation pore; other site 446465000797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465000798 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446465000799 putative substrate translocation pore; other site 446465000800 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 446465000801 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 446465000802 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 446465000803 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 446465000804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465000805 Urb2/Npa2 family; Region: Urb2; pfam10441 446465000806 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446465000807 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 446465000808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465000809 NAD(P) binding site [chemical binding]; other site 446465000810 Bacterial sugar transferase; Region: Bac_transf; pfam02397 446465000811 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465000812 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 446465000813 active site 446465000814 nucleotide binding site [chemical binding]; other site 446465000815 HIGH motif; other site 446465000816 KMSKS motif; other site 446465000817 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 446465000818 FAD binding site [chemical binding]; other site 446465000819 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 446465000820 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 446465000821 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 446465000822 substrate binding site [chemical binding]; other site 446465000823 THF binding site; other site 446465000824 zinc-binding site [ion binding]; other site 446465000825 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446465000826 synthetase active site [active] 446465000827 NTP binding site [chemical binding]; other site 446465000828 metal binding site [ion binding]; metal-binding site 446465000829 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 446465000830 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 446465000831 substrate binding site; other site 446465000832 tetramer interface; other site 446465000833 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 446465000834 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 446465000835 NAD binding site [chemical binding]; other site 446465000836 substrate binding site [chemical binding]; other site 446465000837 homodimer interface [polypeptide binding]; other site 446465000838 active site 446465000839 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 446465000840 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 446465000841 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 446465000842 NADP binding site [chemical binding]; other site 446465000843 active site 446465000844 putative substrate binding site [chemical binding]; other site 446465000845 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 446465000846 histidinol-phosphatase; Provisional; Region: PRK05588 446465000847 active site 446465000848 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 446465000849 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 446465000850 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446465000851 NAD(P) binding site [chemical binding]; other site 446465000852 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 446465000853 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 446465000854 substrate-cofactor binding pocket; other site 446465000855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465000856 catalytic residue [active] 446465000857 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 446465000858 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 446465000859 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 446465000860 Protein export membrane protein; Region: SecD_SecF; cl14618 446465000861 Protein export membrane protein; Region: SecD_SecF; cl14618 446465000862 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 446465000863 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465000864 active site 446465000865 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446465000866 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465000867 active site 446465000868 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465000869 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446465000870 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446465000871 active site 446465000872 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 446465000873 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446465000874 active site 446465000875 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 446465000876 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 446465000877 FOG: PKD repeat [General function prediction only]; Region: COG3291 446465000878 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 446465000879 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 446465000880 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 446465000881 Chain length determinant protein; Region: Wzz; cl15801 446465000882 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 446465000883 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446465000884 Predicted membrane protein [Function unknown]; Region: COG4763 446465000885 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446465000886 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 446465000887 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465000888 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446465000889 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 446465000890 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465000891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446465000892 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446465000893 dimerization interface [polypeptide binding]; other site 446465000894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446465000895 dimer interface [polypeptide binding]; other site 446465000896 phosphorylation site [posttranslational modification] 446465000897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465000898 ATP binding site [chemical binding]; other site 446465000899 G-X-G motif; other site 446465000900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465000901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465000902 active site 446465000903 phosphorylation site [posttranslational modification] 446465000904 intermolecular recognition site; other site 446465000905 dimerization interface [polypeptide binding]; other site 446465000906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446465000907 DNA binding site [nucleotide binding] 446465000908 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 446465000909 dinuclear metal binding motif [ion binding]; other site 446465000910 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446465000911 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465000912 catalytic residue [active] 446465000913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465000914 Coenzyme A binding pocket [chemical binding]; other site 446465000915 DinB superfamily; Region: DinB_2; pfam12867 446465000916 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 446465000917 putative metal binding residues [ion binding]; other site 446465000918 signature motif; other site 446465000919 dimer interface [polypeptide binding]; other site 446465000920 active site 446465000921 polyP binding site; other site 446465000922 substrate binding site [chemical binding]; other site 446465000923 acceptor-phosphate pocket; other site 446465000924 replicative DNA helicase; Region: DnaB; TIGR00665 446465000925 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446465000926 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 446465000927 Walker A motif; other site 446465000928 ATP binding site [chemical binding]; other site 446465000929 Walker B motif; other site 446465000930 DNA binding loops [nucleotide binding] 446465000931 Protein of unknown function, DUF485; Region: DUF485; pfam04341 446465000932 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 446465000933 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 446465000934 Na binding site [ion binding]; other site 446465000935 Predicted membrane protein [Function unknown]; Region: COG2323 446465000936 OsmC-like protein; Region: OsmC; cl00767 446465000937 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 446465000938 xanthine permease; Region: pbuX; TIGR03173 446465000939 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 446465000940 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 446465000941 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446465000942 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446465000943 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465000944 active site 446465000945 ATP binding site [chemical binding]; other site 446465000946 substrate binding site [chemical binding]; other site 446465000947 activation loop (A-loop); other site 446465000948 Beta-lactamase; Region: Beta-lactamase; pfam00144 446465000949 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446465000950 Uncharacterized conserved protein [Function unknown]; Region: COG4279 446465000951 SNF2 Helicase protein; Region: DUF3670; pfam12419 446465000952 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 446465000953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465000954 ATP binding site [chemical binding]; other site 446465000955 putative Mg++ binding site [ion binding]; other site 446465000956 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465000957 nucleotide binding region [chemical binding]; other site 446465000958 ATP-binding site [chemical binding]; other site 446465000959 AAA domain; Region: AAA_31; pfam13614 446465000960 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446465000961 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465000962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446465000963 DNA binding site [nucleotide binding] 446465000964 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446465000965 UreD urease accessory protein; Region: UreD; pfam01774 446465000966 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 446465000967 urease subunit alpha; Reviewed; Region: ureC; PRK13206 446465000968 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 446465000969 subunit interactions [polypeptide binding]; other site 446465000970 active site 446465000971 flap region; other site 446465000972 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 446465000973 gamma-beta subunit interface [polypeptide binding]; other site 446465000974 alpha-beta subunit interface [polypeptide binding]; other site 446465000975 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 446465000976 alpha-gamma subunit interface [polypeptide binding]; other site 446465000977 beta-gamma subunit interface [polypeptide binding]; other site 446465000978 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446465000979 active site 446465000980 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446465000981 nucleoside/Zn binding site; other site 446465000982 dimer interface [polypeptide binding]; other site 446465000983 catalytic motif [active] 446465000984 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446465000985 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446465000986 Walker A/P-loop; other site 446465000987 ATP binding site [chemical binding]; other site 446465000988 Q-loop/lid; other site 446465000989 ABC transporter signature motif; other site 446465000990 Walker B; other site 446465000991 D-loop; other site 446465000992 H-loop/switch region; other site 446465000993 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446465000994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465000995 dimer interface [polypeptide binding]; other site 446465000996 conserved gate region; other site 446465000997 ABC-ATPase subunit interface; other site 446465000998 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 446465000999 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 446465001000 Response regulator receiver domain; Region: Response_reg; pfam00072 446465001001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465001002 active site 446465001003 phosphorylation site [posttranslational modification] 446465001004 intermolecular recognition site; other site 446465001005 dimerization interface [polypeptide binding]; other site 446465001006 Histidine kinase; Region: HisKA_3; pfam07730 446465001007 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 446465001008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465001009 Walker A/P-loop; other site 446465001010 ATP binding site [chemical binding]; other site 446465001011 Q-loop/lid; other site 446465001012 ABC transporter signature motif; other site 446465001013 Walker B; other site 446465001014 D-loop; other site 446465001015 H-loop/switch region; other site 446465001016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001017 putative PBP binding loops; other site 446465001018 ABC-ATPase subunit interface; other site 446465001019 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 446465001020 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 446465001021 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446465001022 classical (c) SDRs; Region: SDR_c; cd05233 446465001023 NAD(P) binding site [chemical binding]; other site 446465001024 active site 446465001025 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 446465001026 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 446465001027 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446465001028 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 446465001029 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446465001030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465001031 non-specific DNA binding site [nucleotide binding]; other site 446465001032 salt bridge; other site 446465001033 sequence-specific DNA binding site [nucleotide binding]; other site 446465001034 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446465001035 Ligand Binding Site [chemical binding]; other site 446465001036 Universal stress protein family; Region: Usp; pfam00582 446465001037 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 446465001038 dimerization domain swap beta strand [polypeptide binding]; other site 446465001039 regulatory protein interface [polypeptide binding]; other site 446465001040 active site 446465001041 regulatory phosphorylation site [posttranslational modification]; other site 446465001042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465001043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465001044 hypothetical protein; Provisional; Region: PRK07906 446465001045 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 446465001046 putative metal binding site [ion binding]; other site 446465001047 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 446465001048 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 446465001049 dimerization interface [polypeptide binding]; other site 446465001050 DPS ferroxidase diiron center [ion binding]; other site 446465001051 ion pore; other site 446465001052 Fe-S metabolism associated domain; Region: SufE; cl00951 446465001053 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446465001054 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446465001055 active site residue [active] 446465001056 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446465001057 active site residue [active] 446465001058 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 446465001059 active site 446465001060 homotetramer interface [polypeptide binding]; other site 446465001061 homodimer interface [polypeptide binding]; other site 446465001062 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465001063 hydrophobic ligand binding site; other site 446465001064 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 446465001065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465001066 S-adenosylmethionine binding site [chemical binding]; other site 446465001067 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 446465001068 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 446465001069 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 446465001070 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465001071 ATP binding site [chemical binding]; other site 446465001072 putative Mg++ binding site [ion binding]; other site 446465001073 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465001074 nucleotide binding region [chemical binding]; other site 446465001075 ATP-binding site [chemical binding]; other site 446465001076 Helicase associated domain (HA2); Region: HA2; cl04503 446465001077 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 446465001078 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 446465001079 BCCT family transporter; Region: BCCT; pfam02028 446465001080 bile acid transporter; Region: bass; TIGR00841 446465001081 Sodium Bile acid symporter family; Region: SBF; pfam01758 446465001082 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446465001083 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446465001084 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446465001085 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 446465001086 quinolinate synthetase; Provisional; Region: PRK09375 446465001087 L-aspartate oxidase; Provisional; Region: PRK06175 446465001088 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 446465001089 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 446465001090 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 446465001091 dimerization interface [polypeptide binding]; other site 446465001092 active site 446465001093 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 446465001094 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 446465001095 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465001096 catalytic residue [active] 446465001097 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 446465001098 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 446465001099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465001100 catalytic residue [active] 446465001101 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 446465001102 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446465001103 DNA binding residues [nucleotide binding] 446465001104 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 446465001105 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 446465001106 active site 446465001107 phosphorylation site [posttranslational modification] 446465001108 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446465001109 nudix motif; other site 446465001110 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465001111 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465001112 active site 446465001113 catalytic tetrad [active] 446465001114 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465001115 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465001116 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465001117 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446465001118 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446465001119 NlpC/P60 family; Region: NLPC_P60; cl17555 446465001120 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 446465001121 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 446465001122 active site 446465001123 Protein of unknown function (DUF819); Region: DUF819; cl02317 446465001124 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 446465001125 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 446465001126 RibD C-terminal domain; Region: RibD_C; cl17279 446465001127 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446465001128 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 446465001129 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 446465001130 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 446465001131 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446465001132 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446465001133 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446465001134 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465001135 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446465001136 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446465001137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001138 dimer interface [polypeptide binding]; other site 446465001139 conserved gate region; other site 446465001140 putative PBP binding loops; other site 446465001141 ABC-ATPase subunit interface; other site 446465001142 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001144 dimer interface [polypeptide binding]; other site 446465001145 conserved gate region; other site 446465001146 putative PBP binding loops; other site 446465001147 ABC-ATPase subunit interface; other site 446465001148 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465001149 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465001150 DNA binding site [nucleotide binding] 446465001151 domain linker motif; other site 446465001152 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465001153 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 446465001154 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 446465001155 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 446465001156 Na binding site [ion binding]; other site 446465001157 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465001158 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465001159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001160 dimer interface [polypeptide binding]; other site 446465001161 conserved gate region; other site 446465001162 ABC-ATPase subunit interface; other site 446465001163 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001165 dimer interface [polypeptide binding]; other site 446465001166 conserved gate region; other site 446465001167 putative PBP binding loops; other site 446465001168 ABC-ATPase subunit interface; other site 446465001169 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 446465001170 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 446465001171 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001173 dimer interface [polypeptide binding]; other site 446465001174 conserved gate region; other site 446465001175 putative PBP binding loops; other site 446465001176 ABC-ATPase subunit interface; other site 446465001177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001178 dimer interface [polypeptide binding]; other site 446465001179 conserved gate region; other site 446465001180 putative PBP binding loops; other site 446465001181 ABC-ATPase subunit interface; other site 446465001182 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465001183 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446465001184 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 446465001185 reactive center loop; other site 446465001186 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 446465001187 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 446465001188 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465001189 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001191 dimer interface [polypeptide binding]; other site 446465001192 conserved gate region; other site 446465001193 putative PBP binding loops; other site 446465001194 ABC-ATPase subunit interface; other site 446465001195 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465001196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001197 conserved gate region; other site 446465001198 ABC-ATPase subunit interface; other site 446465001199 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465001200 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465001201 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465001202 hypothetical protein; Provisional; Region: PRK06184 446465001203 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446465001204 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 446465001205 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 446465001206 Protease prsW family; Region: PrsW-protease; pfam13367 446465001207 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446465001208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465001209 sequence-specific DNA binding site [nucleotide binding]; other site 446465001210 salt bridge; other site 446465001211 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 446465001212 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446465001213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465001214 putative substrate translocation pore; other site 446465001215 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 446465001216 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446465001217 catalytic Zn binding site [ion binding]; other site 446465001218 NAD(P) binding site [chemical binding]; other site 446465001219 structural Zn binding site [ion binding]; other site 446465001220 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465001221 salt bridge; other site 446465001222 non-specific DNA binding site [nucleotide binding]; other site 446465001223 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446465001224 sequence-specific DNA binding site [nucleotide binding]; other site 446465001225 Predicted transcriptional regulators [Transcription]; Region: COG1695 446465001226 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446465001227 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446465001228 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 446465001229 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 446465001230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465001231 S-adenosylmethionine binding site [chemical binding]; other site 446465001232 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446465001233 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446465001234 Walker A/P-loop; other site 446465001235 ATP binding site [chemical binding]; other site 446465001236 Q-loop/lid; other site 446465001237 ABC transporter signature motif; other site 446465001238 Walker B; other site 446465001239 D-loop; other site 446465001240 H-loop/switch region; other site 446465001241 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446465001242 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446465001243 intersubunit interface [polypeptide binding]; other site 446465001244 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446465001245 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446465001246 ABC-ATPase subunit interface; other site 446465001247 dimer interface [polypeptide binding]; other site 446465001248 putative PBP binding regions; other site 446465001249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465001250 putative DNA binding site [nucleotide binding]; other site 446465001251 dimerization interface [polypeptide binding]; other site 446465001252 putative Zn2+ binding site [ion binding]; other site 446465001253 prenyltransferase; Reviewed; Region: ubiA; PRK13105 446465001254 UbiA prenyltransferase family; Region: UbiA; pfam01040 446465001255 phytoene desaturase; Region: crtI_fam; TIGR02734 446465001256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446465001257 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 446465001258 substrate binding pocket [chemical binding]; other site 446465001259 substrate-Mg2+ binding site; other site 446465001260 aspartate-rich region 1; other site 446465001261 aspartate-rich region 2; other site 446465001262 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446465001263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001264 NAD(P) binding site [chemical binding]; other site 446465001265 active site 446465001266 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 446465001267 substrate binding pocket [chemical binding]; other site 446465001268 substrate-Mg2+ binding site; other site 446465001269 aspartate-rich region 1; other site 446465001270 aspartate-rich region 2; other site 446465001271 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 446465001272 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 446465001273 active site 446465001274 metal binding site [ion binding]; metal-binding site 446465001275 nudix motif; other site 446465001276 MarR family; Region: MarR_2; pfam12802 446465001277 FAD binding domain; Region: FAD_binding_3; pfam01494 446465001278 hypothetical protein; Provisional; Region: PRK07236 446465001279 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446465001280 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 446465001281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465001282 S-adenosylmethionine binding site [chemical binding]; other site 446465001283 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 446465001284 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 446465001285 malonyl-CoA binding site [chemical binding]; other site 446465001286 dimer interface [polypeptide binding]; other site 446465001287 active site 446465001288 product binding site; other site 446465001289 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 446465001290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 446465001291 Integrase core domain; Region: rve; pfam00665 446465001292 Integrase core domain; Region: rve_3; pfam13683 446465001293 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446465001294 homotrimer interaction site [polypeptide binding]; other site 446465001295 putative active site [active] 446465001296 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 446465001297 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446465001298 active site 446465001299 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446465001300 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446465001301 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 446465001302 dimer interface [polypeptide binding]; other site 446465001303 active site 446465001304 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446465001305 substrate binding site [chemical binding]; other site 446465001306 catalytic residue [active] 446465001307 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446465001308 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 446465001309 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446465001310 putative NAD(P) binding site [chemical binding]; other site 446465001311 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 446465001312 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 446465001313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446465001314 enoyl-CoA hydratase; Provisional; Region: PRK07657 446465001315 substrate binding site [chemical binding]; other site 446465001316 oxyanion hole (OAH) forming residues; other site 446465001317 trimer interface [polypeptide binding]; other site 446465001318 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446465001319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001320 NAD(P) binding site [chemical binding]; other site 446465001321 active site 446465001322 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 446465001323 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446465001324 active site 446465001325 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 446465001326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465001327 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446465001328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465001329 putative substrate translocation pore; other site 446465001330 putative inner membrane protein; Provisional; Region: PRK11099 446465001331 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 446465001332 CPxP motif; other site 446465001333 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446465001334 DNA binding site [nucleotide binding] 446465001335 active site 446465001336 short chain dehydrogenase; Provisional; Region: PRK06172 446465001337 classical (c) SDRs; Region: SDR_c; cd05233 446465001338 NAD(P) binding site [chemical binding]; other site 446465001339 active site 446465001340 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465001341 Sulfatase; Region: Sulfatase; pfam00884 446465001342 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446465001343 FAD binding domain; Region: FAD_binding_4; pfam01565 446465001344 Berberine and berberine like; Region: BBE; pfam08031 446465001345 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 446465001346 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 446465001347 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 446465001348 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 446465001349 putative ligand binding site [chemical binding]; other site 446465001350 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446465001351 MarR family; Region: MarR_2; pfam12802 446465001352 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465001353 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465001354 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 446465001355 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 446465001356 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446465001357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465001358 Walker A/P-loop; other site 446465001359 ATP binding site [chemical binding]; other site 446465001360 Q-loop/lid; other site 446465001361 ABC transporter signature motif; other site 446465001362 Walker B; other site 446465001363 D-loop; other site 446465001364 H-loop/switch region; other site 446465001365 TOBE domain; Region: TOBE_2; pfam08402 446465001366 TOBE domain; Region: TOBE_2; pfam08402 446465001367 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 446465001368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001369 dimer interface [polypeptide binding]; other site 446465001370 conserved gate region; other site 446465001371 putative PBP binding loops; other site 446465001372 ABC-ATPase subunit interface; other site 446465001373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001374 dimer interface [polypeptide binding]; other site 446465001375 conserved gate region; other site 446465001376 putative PBP binding loops; other site 446465001377 ABC-ATPase subunit interface; other site 446465001378 argininosuccinate lyase; Provisional; Region: PRK00855 446465001379 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 446465001380 tetramer interface [polypeptide binding]; other site 446465001381 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446465001382 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446465001383 ATP binding site [chemical binding]; other site 446465001384 substrate binding site [chemical binding]; other site 446465001385 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446465001386 Amidase; Region: Amidase; pfam01425 446465001387 Amino acid permease; Region: AA_permease_2; pfam13520 446465001388 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446465001389 active site 446465001390 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001392 dimer interface [polypeptide binding]; other site 446465001393 conserved gate region; other site 446465001394 putative PBP binding loops; other site 446465001395 ABC-ATPase subunit interface; other site 446465001396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001397 dimer interface [polypeptide binding]; other site 446465001398 conserved gate region; other site 446465001399 putative PBP binding loops; other site 446465001400 ABC-ATPase subunit interface; other site 446465001401 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 446465001402 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465001403 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465001404 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465001405 DNA binding site [nucleotide binding] 446465001406 domain linker motif; other site 446465001407 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465001408 dimerization interface [polypeptide binding]; other site 446465001409 ligand binding site [chemical binding]; other site 446465001410 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446465001411 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446465001412 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446465001413 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465001414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465001415 ATP binding site [chemical binding]; other site 446465001416 putative Mg++ binding site [ion binding]; other site 446465001417 Helicase_C-like; Region: Helicase_C_4; pfam13871 446465001418 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 446465001419 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 446465001420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446465001421 alpha-galactosidase; Provisional; Region: PRK15076 446465001422 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 446465001423 NAD(P) binding site [chemical binding]; other site 446465001424 LDH/MDH dimer interface [polypeptide binding]; other site 446465001425 substrate binding site [chemical binding]; other site 446465001426 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446465001427 Ligand Binding Site [chemical binding]; other site 446465001428 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446465001429 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446465001430 active site 446465001431 metal binding site [ion binding]; metal-binding site 446465001432 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 446465001433 Trp docking motif [polypeptide binding]; other site 446465001434 active site 446465001435 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 446465001436 Trp docking motif [polypeptide binding]; other site 446465001437 active site 446465001438 PQQ-like domain; Region: PQQ_2; pfam13360 446465001439 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465001440 Sulfatase; Region: Sulfatase; cl17466 446465001441 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 446465001442 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 446465001443 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 446465001444 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 446465001445 hypothetical protein; Provisional; Region: PRK02947 446465001446 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 446465001447 putative active site [active] 446465001448 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 446465001449 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446465001450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465001451 DNA-binding site [nucleotide binding]; DNA binding site 446465001452 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 446465001453 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465001454 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465001455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001456 dimer interface [polypeptide binding]; other site 446465001457 conserved gate region; other site 446465001458 putative PBP binding loops; other site 446465001459 ABC-ATPase subunit interface; other site 446465001460 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001462 dimer interface [polypeptide binding]; other site 446465001463 conserved gate region; other site 446465001464 putative PBP binding loops; other site 446465001465 ABC-ATPase subunit interface; other site 446465001466 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 446465001467 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 446465001468 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 446465001469 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446465001470 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 446465001471 D-lactate dehydrogenase; Provisional; Region: PRK11183 446465001472 FAD binding domain; Region: FAD_binding_4; pfam01565 446465001473 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 446465001474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001475 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446465001476 NAD(P) binding site [chemical binding]; other site 446465001477 active site 446465001478 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 446465001479 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 446465001480 active site 446465001481 Peptidase family C69; Region: Peptidase_C69; pfam03577 446465001482 Predicted membrane protein [Function unknown]; Region: COG4129 446465001483 Uncharacterized conserved protein [Function unknown]; Region: COG4127 446465001484 Restriction endonuclease; Region: Mrr_cat; pfam04471 446465001485 Helix-turn-helix domain; Region: HTH_17; pfam12728 446465001486 QueT transporter; Region: QueT; cl01932 446465001487 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 446465001488 putative homodimer interface [polypeptide binding]; other site 446465001489 PLD-like domain; Region: PLDc_2; pfam13091 446465001490 putative active site [active] 446465001491 catalytic site [active] 446465001492 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465001493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465001494 ATP-binding site [chemical binding]; other site 446465001495 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 446465001496 Mrr N-terminal domain; Region: Mrr_N; pfam14338 446465001497 Restriction endonuclease; Region: Mrr_cat; pfam04471 446465001498 Transposase; Region: HTH_Tnp_1; cl17663 446465001499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 446465001500 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465001501 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465001502 ATP binding site [chemical binding]; other site 446465001503 putative Mg++ binding site [ion binding]; other site 446465001504 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465001505 nucleotide binding region [chemical binding]; other site 446465001506 ATP-binding site [chemical binding]; other site 446465001507 FRG domain; Region: FRG; pfam08867 446465001508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465001509 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465001510 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 446465001511 DNA methylase; Region: N6_N4_Mtase; cl17433 446465001512 DNA methylase; Region: N6_N4_Mtase; pfam01555 446465001513 DNA methylase; Region: N6_N4_Mtase; cl17433 446465001514 Restriction endonuclease [Defense mechanisms]; Region: COG3587 446465001515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465001516 ATP binding site [chemical binding]; other site 446465001517 putative Mg++ binding site [ion binding]; other site 446465001518 potential frameshift: common BLAST hit: gi|86741627|ref|YP_482027.1| protein of unknown function DUF1524 RloF 446465001519 Protein of unknown function DUF262; Region: DUF262; pfam03235 446465001520 Uncharacterized conserved protein [Function unknown]; Region: COG1479 446465001521 Protein of unknown function DUF262; Region: DUF262; pfam03235 446465001522 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 446465001523 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 446465001524 MgtC family; Region: MgtC; pfam02308 446465001525 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 446465001526 hypothetical protein; Reviewed; Region: PRK09588 446465001527 Uncharacterized conserved protein [Function unknown]; Region: COG4127 446465001528 Mrr N-terminal domain; Region: Mrr_N; pfam14338 446465001529 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 446465001530 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446465001531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465001532 Walker A motif; other site 446465001533 ATP binding site [chemical binding]; other site 446465001534 Walker B motif; other site 446465001535 arginine finger; other site 446465001536 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 446465001537 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465001538 active site 446465001539 ATP binding site [chemical binding]; other site 446465001540 substrate binding site [chemical binding]; other site 446465001541 activation loop (A-loop); other site 446465001542 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446465001543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446465001544 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446465001545 DNA binding residues [nucleotide binding] 446465001546 Fic family protein [Function unknown]; Region: COG3177 446465001547 Fic/DOC family; Region: Fic; pfam02661 446465001548 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 446465001549 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 446465001550 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 446465001551 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465001552 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465001553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446465001554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001555 dimer interface [polypeptide binding]; other site 446465001556 conserved gate region; other site 446465001557 putative PBP binding loops; other site 446465001558 ABC-ATPase subunit interface; other site 446465001559 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465001560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001561 putative PBP binding loops; other site 446465001562 ABC-ATPase subunit interface; other site 446465001563 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446465001564 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465001565 Walker A/P-loop; other site 446465001566 ATP binding site [chemical binding]; other site 446465001567 Q-loop/lid; other site 446465001568 ABC transporter signature motif; other site 446465001569 Walker B; other site 446465001570 D-loop; other site 446465001571 H-loop/switch region; other site 446465001572 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465001573 Walker A/P-loop; other site 446465001574 ATP binding site [chemical binding]; other site 446465001575 Q-loop/lid; other site 446465001576 ABC transporter signature motif; other site 446465001577 Walker B; other site 446465001578 D-loop; other site 446465001579 H-loop/switch region; other site 446465001580 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 446465001581 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446465001582 potential frameshift: common BLAST hit: gi|152966696|ref|YP_001362480.1| uncharacterized peroxidase-related enzyme 446465001583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 446465001584 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446465001585 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 446465001586 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 446465001587 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 446465001588 active site 446465001589 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 446465001590 PQQ-like domain; Region: PQQ_2; pfam13360 446465001591 Trp docking motif [polypeptide binding]; other site 446465001592 active site 446465001593 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 446465001594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001595 NAD(P) binding site [chemical binding]; other site 446465001596 active site 446465001597 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 446465001598 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465001599 nucleotide binding site [chemical binding]; other site 446465001600 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446465001601 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446465001602 Ferritin-like domain; Region: Ferritin; pfam00210 446465001603 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 446465001604 dimerization interface [polypeptide binding]; other site 446465001605 DPS ferroxidase diiron center [ion binding]; other site 446465001606 ion pore; other site 446465001607 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465001608 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465001609 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 446465001610 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 446465001611 active site 446465001612 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 446465001613 active site 446465001614 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 446465001615 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465001616 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465001617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001618 dimer interface [polypeptide binding]; other site 446465001619 conserved gate region; other site 446465001620 putative PBP binding loops; other site 446465001621 ABC-ATPase subunit interface; other site 446465001622 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001624 dimer interface [polypeptide binding]; other site 446465001625 conserved gate region; other site 446465001626 putative PBP binding loops; other site 446465001627 ABC-ATPase subunit interface; other site 446465001628 Helix-turn-helix domain; Region: HTH_18; pfam12833 446465001629 RibD C-terminal domain; Region: RibD_C; cl17279 446465001630 CsbD-like; Region: CsbD; pfam05532 446465001631 aconitate hydratase; Validated; Region: PRK07229 446465001632 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446465001633 substrate binding site [chemical binding]; other site 446465001634 ligand binding site [chemical binding]; other site 446465001635 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 446465001636 substrate binding site [chemical binding]; other site 446465001637 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 446465001638 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 446465001639 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 446465001640 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446465001641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465001642 putative substrate translocation pore; other site 446465001643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465001644 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465001645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465001646 active site 446465001647 phosphorylation site [posttranslational modification] 446465001648 intermolecular recognition site; other site 446465001649 dimerization interface [polypeptide binding]; other site 446465001650 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446465001651 DNA binding residues [nucleotide binding] 446465001652 dimerization interface [polypeptide binding]; other site 446465001653 Histidine kinase; Region: HisKA_3; pfam07730 446465001654 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446465001655 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 446465001656 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465001657 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465001658 DNA binding site [nucleotide binding] 446465001659 domain linker motif; other site 446465001660 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465001661 ligand binding site [chemical binding]; other site 446465001662 dimerization interface [polypeptide binding]; other site 446465001663 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446465001664 Uncharacterized conserved protein [Function unknown]; Region: COG1262 446465001665 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 446465001666 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446465001667 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446465001668 ATP binding site [chemical binding]; other site 446465001669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465001670 non-specific DNA binding site [nucleotide binding]; other site 446465001671 salt bridge; other site 446465001672 sequence-specific DNA binding site [nucleotide binding]; other site 446465001673 Cupin domain; Region: Cupin_2; cl17218 446465001674 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 446465001675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465001676 Coenzyme A binding pocket [chemical binding]; other site 446465001677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465001678 NAD(P) binding site [chemical binding]; other site 446465001679 active site 446465001680 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465001681 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465001682 active site 446465001683 catalytic tetrad [active] 446465001684 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 446465001685 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446465001686 active site 446465001687 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 446465001688 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446465001689 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446465001690 Glutaminase; Region: Glutaminase; cl00907 446465001691 Glutaminase; Region: Glutaminase; cl00907 446465001692 Sulfatase; Region: Sulfatase; cl17466 446465001693 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465001694 HflK protein; Region: hflK; TIGR01933 446465001695 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 446465001696 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 446465001697 catalytic residues [active] 446465001698 dimer interface [polypeptide binding]; other site 446465001699 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446465001700 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446465001701 substrate binding site [chemical binding]; other site 446465001702 ATP binding site [chemical binding]; other site 446465001703 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446465001704 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446465001705 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446465001706 nucleoside/Zn binding site; other site 446465001707 dimer interface [polypeptide binding]; other site 446465001708 catalytic motif [active] 446465001709 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446465001710 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 446465001711 active site 446465001712 FMN binding site [chemical binding]; other site 446465001713 2,4-decadienoyl-CoA binding site; other site 446465001714 catalytic residue [active] 446465001715 4Fe-4S cluster binding site [ion binding]; other site 446465001716 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446465001717 Isochorismatase family; Region: Isochorismatase; pfam00857 446465001718 catalytic triad [active] 446465001719 conserved cis-peptide bond; other site 446465001720 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465001721 active site 446465001722 AAA ATPase domain; Region: AAA_16; pfam13191 446465001723 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 446465001724 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 446465001725 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446465001726 DNA binding residues [nucleotide binding] 446465001727 drug binding residues [chemical binding]; other site 446465001728 dimer interface [polypeptide binding]; other site 446465001729 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446465001730 active site 446465001731 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446465001732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465001733 Coenzyme A binding pocket [chemical binding]; other site 446465001734 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 446465001735 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465001736 hydrophobic ligand binding site; other site 446465001737 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 446465001738 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446465001739 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446465001740 Walker A/P-loop; other site 446465001741 ATP binding site [chemical binding]; other site 446465001742 Q-loop/lid; other site 446465001743 ABC transporter signature motif; other site 446465001744 Walker B; other site 446465001745 D-loop; other site 446465001746 H-loop/switch region; other site 446465001747 Predicted transcriptional regulators [Transcription]; Region: COG1695 446465001748 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446465001749 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 446465001750 ATP binding site [chemical binding]; other site 446465001751 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446465001752 active site 446465001753 Predicted membrane protein [Function unknown]; Region: COG4270 446465001754 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465001755 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465001756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001757 dimer interface [polypeptide binding]; other site 446465001758 conserved gate region; other site 446465001759 putative PBP binding loops; other site 446465001760 ABC-ATPase subunit interface; other site 446465001761 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465001762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465001763 dimer interface [polypeptide binding]; other site 446465001764 conserved gate region; other site 446465001765 putative PBP binding loops; other site 446465001766 ABC-ATPase subunit interface; other site 446465001767 Amidohydrolase family; Region: Amidohydro_3; pfam07969 446465001768 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446465001769 active site 446465001770 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446465001771 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446465001772 Walker A/P-loop; other site 446465001773 ATP binding site [chemical binding]; other site 446465001774 Q-loop/lid; other site 446465001775 ABC transporter signature motif; other site 446465001776 Walker B; other site 446465001777 D-loop; other site 446465001778 H-loop/switch region; other site 446465001779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446465001780 Histidine kinase; Region: HisKA_3; pfam07730 446465001781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465001782 ATP binding site [chemical binding]; other site 446465001783 Mg2+ binding site [ion binding]; other site 446465001784 G-X-G motif; other site 446465001785 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465001786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465001787 active site 446465001788 phosphorylation site [posttranslational modification] 446465001789 intermolecular recognition site; other site 446465001790 dimerization interface [polypeptide binding]; other site 446465001791 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446465001792 DNA binding residues [nucleotide binding] 446465001793 dimerization interface [polypeptide binding]; other site 446465001794 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465001795 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465001796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465001797 Walker A/P-loop; other site 446465001798 ATP binding site [chemical binding]; other site 446465001799 Q-loop/lid; other site 446465001800 ABC transporter signature motif; other site 446465001801 Walker B; other site 446465001802 D-loop; other site 446465001803 H-loop/switch region; other site 446465001804 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 446465001805 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446465001806 Walker A/P-loop; other site 446465001807 ATP binding site [chemical binding]; other site 446465001808 Q-loop/lid; other site 446465001809 ABC transporter signature motif; other site 446465001810 Walker B; other site 446465001811 D-loop; other site 446465001812 H-loop/switch region; other site 446465001813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465001814 dimerization interface [polypeptide binding]; other site 446465001815 putative DNA binding site [nucleotide binding]; other site 446465001816 putative Zn2+ binding site [ion binding]; other site 446465001817 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 446465001818 Short C-terminal domain; Region: SHOCT; pfam09851 446465001819 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 446465001820 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 446465001821 FAD binding domain; Region: FAD_binding_2; pfam00890 446465001822 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446465001823 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446465001824 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446465001825 putative metal binding site [ion binding]; other site 446465001826 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 446465001827 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446465001828 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446465001829 active site residue [active] 446465001830 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446465001831 active site residue [active] 446465001832 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 446465001833 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446465001834 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_3; cd12160 446465001835 putative ligand binding site [chemical binding]; other site 446465001836 putative NAD binding site [chemical binding]; other site 446465001837 catalytic site [active] 446465001838 BCCT family transporter; Region: BCCT; pfam02028 446465001839 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 446465001840 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 446465001841 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446465001842 arginine-tRNA ligase; Region: PLN02286 446465001843 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 446465001844 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465001845 active site 446465001846 HIGH motif; other site 446465001847 nucleotide binding site [chemical binding]; other site 446465001848 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 446465001849 KMSK motif region; other site 446465001850 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446465001851 tRNA binding surface [nucleotide binding]; other site 446465001852 anticodon binding site; other site 446465001853 hypothetical protein; Provisional; Region: PRK11770 446465001854 Domain of unknown function (DUF307); Region: DUF307; pfam03733 446465001855 Domain of unknown function (DUF307); Region: DUF307; pfam03733 446465001856 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 446465001857 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446465001858 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446465001859 uracil transporter; Provisional; Region: PRK10720 446465001860 ornithine cyclodeaminase; Validated; Region: PRK07589 446465001861 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 446465001862 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 446465001863 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 446465001864 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 446465001865 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 446465001866 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 446465001867 Ca binding site [ion binding]; other site 446465001868 active site 446465001869 catalytic site [active] 446465001870 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 446465001871 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 446465001872 Glutaminase; Region: Glutaminase; cl00907 446465001873 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446465001874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465001875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446465001876 Coenzyme A binding pocket [chemical binding]; other site 446465001877 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465001878 active site 446465001879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465001880 DNA-binding site [nucleotide binding]; DNA binding site 446465001881 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446465001882 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465001883 active site 446465001884 prephenate dehydratase; Provisional; Region: PRK11898 446465001885 Prephenate dehydratase; Region: PDT; pfam00800 446465001886 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 446465001887 putative L-Phe binding site [chemical binding]; other site 446465001888 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 446465001889 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 446465001890 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446465001891 Ligand Binding Site [chemical binding]; other site 446465001892 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446465001893 Ligand Binding Site [chemical binding]; other site 446465001894 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 446465001895 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 446465001896 seryl-tRNA synthetase; Provisional; Region: PRK05431 446465001897 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 446465001898 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 446465001899 dimer interface [polypeptide binding]; other site 446465001900 active site 446465001901 motif 1; other site 446465001902 motif 2; other site 446465001903 motif 3; other site 446465001904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465001905 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 446465001906 active site 446465001907 motif I; other site 446465001908 motif II; other site 446465001909 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465001910 Enoylreductase; Region: PKS_ER; smart00829 446465001911 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 446465001912 NAD(P) binding site [chemical binding]; other site 446465001913 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 446465001914 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 446465001915 NADP binding site [chemical binding]; other site 446465001916 dimer interface [polypeptide binding]; other site 446465001917 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 446465001918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465001919 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465001920 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 446465001921 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446465001922 active site 446465001923 Ca binding site [ion binding]; other site 446465001924 catalytic site [active] 446465001925 Aamy_C domain; Region: Aamy_C; smart00632 446465001926 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 446465001927 nucleotide binding site/active site [active] 446465001928 HIT family signature motif; other site 446465001929 catalytic residue [active] 446465001930 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 446465001931 Predicted transcriptional regulators [Transcription]; Region: COG1725 446465001932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465001933 DNA-binding site [nucleotide binding]; DNA binding site 446465001934 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446465001935 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446465001936 Walker A/P-loop; other site 446465001937 ATP binding site [chemical binding]; other site 446465001938 Q-loop/lid; other site 446465001939 ABC transporter signature motif; other site 446465001940 Walker B; other site 446465001941 D-loop; other site 446465001942 H-loop/switch region; other site 446465001943 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 446465001944 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 446465001945 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 446465001946 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446465001947 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 446465001948 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 446465001949 dimerization domain swap beta strand [polypeptide binding]; other site 446465001950 regulatory protein interface [polypeptide binding]; other site 446465001951 active site 446465001952 regulatory phosphorylation site [posttranslational modification]; other site 446465001953 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 446465001954 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 446465001955 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 446465001956 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 446465001957 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 446465001958 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 446465001959 active site 446465001960 P-loop; other site 446465001961 phosphorylation site [posttranslational modification] 446465001962 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 446465001963 active site 446465001964 phosphorylation site [posttranslational modification] 446465001965 Uncharacterized conserved protein [Function unknown]; Region: COG0398 446465001966 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446465001967 Uncharacterized conserved protein [Function unknown]; Region: COG1359 446465001968 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 446465001969 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 446465001970 putative DNA binding site [nucleotide binding]; other site 446465001971 putative homodimer interface [polypeptide binding]; other site 446465001972 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 446465001973 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 446465001974 nucleotide binding site [chemical binding]; other site 446465001975 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 446465001976 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 446465001977 active site 446465001978 DNA binding site [nucleotide binding] 446465001979 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 446465001980 DNA binding site [nucleotide binding] 446465001981 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446465001982 DNA-binding site [nucleotide binding]; DNA binding site 446465001983 RNA-binding motif; other site 446465001984 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 446465001985 Lipase maturation factor; Region: LMF1; pfam06762 446465001986 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446465001987 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 446465001988 putative NAD(P) binding site [chemical binding]; other site 446465001989 catalytic Zn binding site [ion binding]; other site 446465001990 structural Zn binding site [ion binding]; other site 446465001991 BioY family; Region: BioY; pfam02632 446465001992 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 446465001993 putative active site [active] 446465001994 CAAX protease self-immunity; Region: Abi; pfam02517 446465001995 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465001996 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465001997 DNA binding site [nucleotide binding] 446465001998 domain linker motif; other site 446465001999 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465002000 ligand binding site [chemical binding]; other site 446465002001 dimerization interface [polypeptide binding]; other site 446465002002 Ion channel; Region: Ion_trans_2; pfam07885 446465002003 TrkA-C domain; Region: TrkA_C; pfam02080 446465002004 TrkA-N domain; Region: TrkA_N; pfam02254 446465002005 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 446465002006 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446465002007 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 446465002008 catalytic triad [active] 446465002009 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446465002010 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465002011 DNA-binding site [nucleotide binding]; DNA binding site 446465002012 FCD domain; Region: FCD; pfam07729 446465002013 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 446465002014 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446465002015 substrate binding pocket [chemical binding]; other site 446465002016 membrane-bound complex binding site; other site 446465002017 hinge residues; other site 446465002018 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446465002019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465002020 dimer interface [polypeptide binding]; other site 446465002021 conserved gate region; other site 446465002022 putative PBP binding loops; other site 446465002023 ABC-ATPase subunit interface; other site 446465002024 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446465002025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465002026 dimer interface [polypeptide binding]; other site 446465002027 conserved gate region; other site 446465002028 putative PBP binding loops; other site 446465002029 ABC-ATPase subunit interface; other site 446465002030 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446465002031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465002032 Walker A/P-loop; other site 446465002033 ATP binding site [chemical binding]; other site 446465002034 Q-loop/lid; other site 446465002035 ABC transporter signature motif; other site 446465002036 Walker B; other site 446465002037 D-loop; other site 446465002038 H-loop/switch region; other site 446465002039 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 446465002040 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 446465002041 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465002042 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465002043 active site 446465002044 catalytic tetrad [active] 446465002045 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446465002046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465002047 Coenzyme A binding pocket [chemical binding]; other site 446465002048 Uncharacterized conserved protein [Function unknown]; Region: COG4850 446465002049 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 446465002050 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446465002051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465002052 Coenzyme A binding pocket [chemical binding]; other site 446465002053 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446465002054 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446465002055 active site 446465002056 phosphoglucomutase; Validated; Region: PRK07564 446465002057 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 446465002058 active site 446465002059 substrate binding site [chemical binding]; other site 446465002060 metal binding site [ion binding]; metal-binding site 446465002061 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 446465002062 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 446465002063 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446465002064 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 446465002065 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465002066 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465002067 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465002068 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446465002069 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465002070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465002071 dimer interface [polypeptide binding]; other site 446465002072 conserved gate region; other site 446465002073 putative PBP binding loops; other site 446465002074 ABC-ATPase subunit interface; other site 446465002075 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 446465002076 Melibiase; Region: Melibiase; pfam02065 446465002077 aminotransferase AlaT; Validated; Region: PRK09265 446465002078 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465002079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465002080 homodimer interface [polypeptide binding]; other site 446465002081 catalytic residue [active] 446465002082 ferredoxin-NADP+ reductase; Region: PLN02852 446465002083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446465002084 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 446465002085 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 446465002086 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 446465002087 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 446465002088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 446465002089 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 446465002090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446465002091 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465002092 active site 446465002093 ATP binding site [chemical binding]; other site 446465002094 substrate binding site [chemical binding]; other site 446465002095 activation loop (A-loop); other site 446465002096 Thioredoxin; Region: Thioredoxin_4; cl17273 446465002097 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 446465002098 ligand binding site [chemical binding]; other site 446465002099 active site 446465002100 UGI interface [polypeptide binding]; other site 446465002101 catalytic site [active] 446465002102 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 446465002103 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 446465002104 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 446465002105 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 446465002106 ring oligomerisation interface [polypeptide binding]; other site 446465002107 ATP/Mg binding site [chemical binding]; other site 446465002108 stacking interactions; other site 446465002109 hinge regions; other site 446465002110 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 446465002111 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465002112 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446465002113 Walker A/P-loop; other site 446465002114 ATP binding site [chemical binding]; other site 446465002115 Q-loop/lid; other site 446465002116 ABC transporter signature motif; other site 446465002117 Walker B; other site 446465002118 D-loop; other site 446465002119 H-loop/switch region; other site 446465002120 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 446465002121 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465002122 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446465002123 Walker A/P-loop; other site 446465002124 ATP binding site [chemical binding]; other site 446465002125 Q-loop/lid; other site 446465002126 ABC transporter signature motif; other site 446465002127 Walker B; other site 446465002128 D-loop; other site 446465002129 H-loop/switch region; other site 446465002130 hypothetical protein; Provisional; Region: PRK13661 446465002131 Uncharacterized conserved protein [Function unknown]; Region: COG1912 446465002132 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 446465002133 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 446465002134 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 446465002135 DctM-like transporters; Region: DctM; pfam06808 446465002136 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 446465002137 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 446465002138 putative catalytic site [active] 446465002139 putative metal binding site [ion binding]; other site 446465002140 putative phosphate binding site [ion binding]; other site 446465002141 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 446465002142 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465002143 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 446465002144 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465002145 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 446465002146 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 446465002147 nucleotide binding site/active site [active] 446465002148 HIT family signature motif; other site 446465002149 catalytic residue [active] 446465002150 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 446465002151 AAA domain; Region: AAA_18; pfam13238 446465002152 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 446465002153 active site 446465002154 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 446465002155 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 446465002156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465002157 dimerization interface [polypeptide binding]; other site 446465002158 putative DNA binding site [nucleotide binding]; other site 446465002159 putative Zn2+ binding site [ion binding]; other site 446465002160 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446465002161 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465002162 ATP binding site [chemical binding]; other site 446465002163 Mg++ binding site [ion binding]; other site 446465002164 motif III; other site 446465002165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465002166 nucleotide binding region [chemical binding]; other site 446465002167 ATP-binding site [chemical binding]; other site 446465002168 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465002169 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465002170 DNA binding site [nucleotide binding] 446465002171 domain linker motif; other site 446465002172 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465002173 ligand binding site [chemical binding]; other site 446465002174 dimerization interface [polypeptide binding]; other site 446465002175 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446465002176 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 446465002177 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 446465002178 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 446465002179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465002180 S-adenosylmethionine binding site [chemical binding]; other site 446465002181 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 446465002182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465002183 Coenzyme A binding pocket [chemical binding]; other site 446465002184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465002185 Coenzyme A binding pocket [chemical binding]; other site 446465002186 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465002187 DNA-binding site [nucleotide binding]; DNA binding site 446465002188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465002189 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465002190 Walker A/P-loop; other site 446465002191 ATP binding site [chemical binding]; other site 446465002192 Q-loop/lid; other site 446465002193 ABC transporter signature motif; other site 446465002194 Walker B; other site 446465002195 D-loop; other site 446465002196 H-loop/switch region; other site 446465002197 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 446465002198 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446465002199 putative NAD(P) binding site [chemical binding]; other site 446465002200 catalytic Zn binding site [ion binding]; other site 446465002201 structural Zn binding site [ion binding]; other site 446465002202 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 446465002203 RNA/DNA hybrid binding site [nucleotide binding]; other site 446465002204 active site 446465002205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 446465002206 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 446465002207 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465002208 active site 446465002209 Predicted membrane protein [Function unknown]; Region: COG2311 446465002210 Protein of unknown function (DUF418); Region: DUF418; cl12135 446465002211 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446465002212 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 446465002213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446465002214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446465002215 dimerization interface [polypeptide binding]; other site 446465002216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446465002217 dimer interface [polypeptide binding]; other site 446465002218 phosphorylation site [posttranslational modification] 446465002219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465002220 ATP binding site [chemical binding]; other site 446465002221 Mg2+ binding site [ion binding]; other site 446465002222 G-X-G motif; other site 446465002223 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465002224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465002225 active site 446465002226 phosphorylation site [posttranslational modification] 446465002227 intermolecular recognition site; other site 446465002228 dimerization interface [polypeptide binding]; other site 446465002229 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446465002230 DNA binding site [nucleotide binding] 446465002231 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 446465002232 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 446465002233 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446465002234 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 446465002235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 446465002236 ATP binding site [chemical binding]; other site 446465002237 putative Mg++ binding site [ion binding]; other site 446465002238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465002239 nucleotide binding region [chemical binding]; other site 446465002240 ATP-binding site [chemical binding]; other site 446465002241 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446465002242 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 446465002243 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 446465002244 RDD family; Region: RDD; pfam06271 446465002245 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 446465002246 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 446465002247 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 446465002248 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446465002249 catalytic residue [active] 446465002250 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465002251 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465002252 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446465002253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002254 putative substrate translocation pore; other site 446465002255 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 446465002256 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446465002257 homodimer interface [polypeptide binding]; other site 446465002258 substrate-cofactor binding pocket; other site 446465002259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465002260 catalytic residue [active] 446465002261 Bax inhibitor 1 like; Region: BaxI_1; cl17691 446465002262 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 446465002263 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 446465002264 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446465002265 putative active site [active] 446465002266 catalytic site [active] 446465002267 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 446465002268 putative active site [active] 446465002269 catalytic site [active] 446465002270 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 446465002271 dimer interface [polypeptide binding]; other site 446465002272 substrate binding site [chemical binding]; other site 446465002273 ATP binding site [chemical binding]; other site 446465002274 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446465002275 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446465002276 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 446465002277 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446465002278 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446465002279 TAP-like protein; Region: Abhydrolase_4; pfam08386 446465002280 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 446465002281 allantoinase; Region: allantoinase; TIGR03178 446465002282 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446465002283 active site 446465002284 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 446465002285 glyoxylate carboligase; Provisional; Region: PRK11269 446465002286 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446465002287 PYR/PP interface [polypeptide binding]; other site 446465002288 dimer interface [polypeptide binding]; other site 446465002289 TPP binding site [chemical binding]; other site 446465002290 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446465002291 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 446465002292 TPP-binding site [chemical binding]; other site 446465002293 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446465002294 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446465002295 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 446465002296 hypothetical protein; Provisional; Region: PRK11171 446465002297 Cupin domain; Region: Cupin_2; pfam07883 446465002298 Cupin domain; Region: Cupin_2; pfam07883 446465002299 malate synthase A; Region: malate_syn_A; TIGR01344 446465002300 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 446465002301 active site 446465002302 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446465002303 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 446465002304 Malic enzyme, N-terminal domain; Region: malic; pfam00390 446465002305 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 446465002306 putative NAD(P) binding site [chemical binding]; other site 446465002307 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446465002308 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446465002309 Bacterial transcriptional regulator; Region: IclR; pfam01614 446465002310 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 446465002311 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 446465002312 dimer interface [polypeptide binding]; other site 446465002313 TPP-binding site [chemical binding]; other site 446465002314 xanthine permease; Region: pbuX; TIGR03173 446465002315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002316 urate oxidase; Region: urate_oxi; TIGR03383 446465002317 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 446465002318 active site 446465002319 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 446465002320 active site 446465002321 homotetramer interface [polypeptide binding]; other site 446465002322 putative OHCU decarboxylase; Provisional; Region: PRK13798 446465002323 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446465002324 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 446465002325 catalytic triad [active] 446465002326 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 446465002327 catalytic site [active] 446465002328 BNR repeat-like domain; Region: BNR_2; pfam13088 446465002329 Asp-box motif; other site 446465002330 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 446465002331 catalytic site [active] 446465002332 BNR repeat-like domain; Region: BNR_2; pfam13088 446465002333 Asp-box motif; other site 446465002334 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 446465002335 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 446465002336 putative active site cavity [active] 446465002337 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465002338 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465002339 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446465002340 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 446465002341 active site 446465002342 inhibitor site; inhibition site 446465002343 dimer interface [polypeptide binding]; other site 446465002344 catalytic residue [active] 446465002345 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465002346 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465002347 Walker A/P-loop; other site 446465002348 ATP binding site [chemical binding]; other site 446465002349 Q-loop/lid; other site 446465002350 ABC transporter signature motif; other site 446465002351 Walker B; other site 446465002352 D-loop; other site 446465002353 H-loop/switch region; other site 446465002354 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 446465002355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465002356 dimer interface [polypeptide binding]; other site 446465002357 conserved gate region; other site 446465002358 putative PBP binding loops; other site 446465002359 ABC-ATPase subunit interface; other site 446465002360 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446465002361 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465002362 Walker A/P-loop; other site 446465002363 ATP binding site [chemical binding]; other site 446465002364 Q-loop/lid; other site 446465002365 ABC transporter signature motif; other site 446465002366 Walker B; other site 446465002367 D-loop; other site 446465002368 H-loop/switch region; other site 446465002369 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465002370 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465002371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465002372 dimer interface [polypeptide binding]; other site 446465002373 conserved gate region; other site 446465002374 putative PBP binding loops; other site 446465002375 ABC-ATPase subunit interface; other site 446465002376 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446465002377 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446465002378 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465002379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465002380 DNA-binding site [nucleotide binding]; DNA binding site 446465002381 FCD domain; Region: FCD; pfam07729 446465002382 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 446465002383 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 446465002384 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446465002385 Protein of unknown function DUF58; Region: DUF58; pfam01882 446465002386 MoxR-like ATPases [General function prediction only]; Region: COG0714 446465002387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465002388 Walker A motif; other site 446465002389 ATP binding site [chemical binding]; other site 446465002390 Walker B motif; other site 446465002391 arginine finger; other site 446465002392 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446465002393 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465002394 Walker A/P-loop; other site 446465002395 ATP binding site [chemical binding]; other site 446465002396 Q-loop/lid; other site 446465002397 ABC transporter signature motif; other site 446465002398 Walker B; other site 446465002399 D-loop; other site 446465002400 H-loop/switch region; other site 446465002401 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465002402 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465002403 Walker A/P-loop; other site 446465002404 ATP binding site [chemical binding]; other site 446465002405 Q-loop/lid; other site 446465002406 ABC transporter signature motif; other site 446465002407 Walker B; other site 446465002408 D-loop; other site 446465002409 H-loop/switch region; other site 446465002410 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446465002411 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 446465002412 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465002413 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465002414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465002415 dimer interface [polypeptide binding]; other site 446465002416 conserved gate region; other site 446465002417 putative PBP binding loops; other site 446465002418 ABC-ATPase subunit interface; other site 446465002419 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465002420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465002421 putative PBP binding loops; other site 446465002422 dimer interface [polypeptide binding]; other site 446465002423 ABC-ATPase subunit interface; other site 446465002424 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 446465002425 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446465002426 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446465002427 putative NAD(P) binding site [chemical binding]; other site 446465002428 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446465002429 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 446465002430 dimer interface [polypeptide binding]; other site 446465002431 putative functional site; other site 446465002432 putative MPT binding site; other site 446465002433 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 446465002434 ATP binding site [chemical binding]; other site 446465002435 substrate interface [chemical binding]; other site 446465002436 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446465002437 active site residue [active] 446465002438 Ubiquitin-like proteins; Region: UBQ; cl00155 446465002439 charged pocket; other site 446465002440 hydrophobic patch; other site 446465002441 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 446465002442 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446465002443 FeS/SAM binding site; other site 446465002444 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 446465002445 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 446465002446 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446465002447 dimer interface [polypeptide binding]; other site 446465002448 putative functional site; other site 446465002449 putative MPT binding site; other site 446465002450 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 446465002451 trimer interface [polypeptide binding]; other site 446465002452 dimer interface [polypeptide binding]; other site 446465002453 putative active site [active] 446465002454 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 446465002455 MPT binding site; other site 446465002456 trimer interface [polypeptide binding]; other site 446465002457 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 446465002458 MoaE homodimer interface [polypeptide binding]; other site 446465002459 MoaD interaction [polypeptide binding]; other site 446465002460 active site residues [active] 446465002461 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446465002462 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446465002463 active site 446465002464 metal binding site [ion binding]; metal-binding site 446465002465 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 446465002466 oligomerisation interface [polypeptide binding]; other site 446465002467 mobile loop; other site 446465002468 roof hairpin; other site 446465002469 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 446465002470 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 446465002471 ring oligomerisation interface [polypeptide binding]; other site 446465002472 ATP/Mg binding site [chemical binding]; other site 446465002473 stacking interactions; other site 446465002474 hinge regions; other site 446465002475 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 446465002476 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 446465002477 active site 446465002478 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 446465002479 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 446465002480 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 446465002481 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446465002482 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 446465002483 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 446465002484 active site 446465002485 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446465002486 dimer interface [polypeptide binding]; other site 446465002487 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446465002488 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 446465002489 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446465002490 active site 446465002491 catalytic site [active] 446465002492 substrate binding site [chemical binding]; other site 446465002493 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 446465002494 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446465002495 phosphate binding site [ion binding]; other site 446465002496 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 446465002497 heme binding pocket [chemical binding]; other site 446465002498 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 446465002499 propionate/acetate kinase; Provisional; Region: PRK12379 446465002500 phosphate acetyltransferase; Reviewed; Region: PRK05632 446465002501 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446465002502 DRTGG domain; Region: DRTGG; pfam07085 446465002503 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 446465002504 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 446465002505 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 446465002506 GMP synthase; Reviewed; Region: guaA; PRK00074 446465002507 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 446465002508 AMP/PPi binding site [chemical binding]; other site 446465002509 candidate oxyanion hole; other site 446465002510 catalytic triad [active] 446465002511 potential glutamine specificity residues [chemical binding]; other site 446465002512 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 446465002513 ATP Binding subdomain [chemical binding]; other site 446465002514 Ligand Binding sites [chemical binding]; other site 446465002515 Dimerization subdomain; other site 446465002516 benzoate transport; Region: 2A0115; TIGR00895 446465002517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002518 putative substrate translocation pore; other site 446465002519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446465002522 putative substrate translocation pore; other site 446465002523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002524 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446465002525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465002526 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465002527 catalytic core [active] 446465002528 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 446465002529 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446465002530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465002531 motif II; other site 446465002532 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 446465002533 putative active site [active] 446465002534 dimerization interface [polypeptide binding]; other site 446465002535 putative tRNAtyr binding site [nucleotide binding]; other site 446465002536 Phosphotransferase enzyme family; Region: APH; pfam01636 446465002537 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446465002538 active site 446465002539 ATP binding site [chemical binding]; other site 446465002540 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 446465002541 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 446465002542 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 446465002543 GDP-binding site [chemical binding]; other site 446465002544 ACT binding site; other site 446465002545 IMP binding site; other site 446465002546 CutC family; Region: CutC; cl01218 446465002547 amidophosphoribosyltransferase; Provisional; Region: PRK07847 446465002548 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 446465002549 active site 446465002550 tetramer interface [polypeptide binding]; other site 446465002551 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446465002552 active site 446465002553 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 446465002554 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 446465002555 dimerization interface [polypeptide binding]; other site 446465002556 putative ATP binding site [chemical binding]; other site 446465002557 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 446465002558 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446465002559 DNA binding residues [nucleotide binding] 446465002560 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446465002561 Serine hydrolase; Region: Ser_hydrolase; cl17834 446465002562 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446465002563 Part of AAA domain; Region: AAA_19; pfam13245 446465002564 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 446465002565 Family description; Region: UvrD_C_2; pfam13538 446465002566 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 446465002567 putative dimer interface [polypeptide binding]; other site 446465002568 ligand binding site [chemical binding]; other site 446465002569 Zn binding site [ion binding]; other site 446465002570 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 446465002571 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 446465002572 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 446465002573 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 446465002574 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 446465002575 CoA-ligase; Region: Ligase_CoA; pfam00549 446465002576 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 446465002577 CoA binding domain; Region: CoA_binding; smart00881 446465002578 CoA-ligase; Region: Ligase_CoA; pfam00549 446465002579 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 446465002580 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 446465002581 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 446465002582 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446465002583 NlpC/P60 family; Region: NLPC_P60; pfam00877 446465002584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465002585 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 446465002586 active site 446465002587 motif I; other site 446465002588 motif II; other site 446465002589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 446465002590 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 446465002591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446465002592 mycothione reductase; Reviewed; Region: PRK07846 446465002593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446465002594 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446465002595 Transcriptional regulator [Transcription]; Region: LytR; COG1316 446465002596 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 446465002597 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446465002598 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 446465002599 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 446465002600 active site 446465002601 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 446465002602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465002603 NAD(P) binding site [chemical binding]; other site 446465002604 active site 446465002605 threonine dehydratase; Validated; Region: PRK08639 446465002606 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446465002607 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465002608 catalytic residue [active] 446465002609 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 446465002610 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 446465002611 homotrimer interaction site [polypeptide binding]; other site 446465002612 zinc binding site [ion binding]; other site 446465002613 CDP-binding sites; other site 446465002614 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 446465002615 active site 446465002616 P-loop; other site 446465002617 phosphorylation site [posttranslational modification] 446465002618 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 446465002619 substrate binding site; other site 446465002620 dimer interface; other site 446465002621 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465002622 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 446465002623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465002624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465002625 active site 446465002626 phosphorylation site [posttranslational modification] 446465002627 intermolecular recognition site; other site 446465002628 dimerization interface [polypeptide binding]; other site 446465002629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446465002630 DNA binding site [nucleotide binding] 446465002631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446465002632 dimer interface [polypeptide binding]; other site 446465002633 phosphorylation site [posttranslational modification] 446465002634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465002635 ATP binding site [chemical binding]; other site 446465002636 Mg2+ binding site [ion binding]; other site 446465002637 G-X-G motif; other site 446465002638 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 446465002639 PhoU domain; Region: PhoU; pfam01895 446465002640 PhoU domain; Region: PhoU; pfam01895 446465002641 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 446465002642 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 446465002643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465002644 S-adenosylmethionine binding site [chemical binding]; other site 446465002645 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 446465002646 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 446465002647 iron-sulfur cluster [ion binding]; other site 446465002648 [2Fe-2S] cluster binding site [ion binding]; other site 446465002649 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446465002650 active site 446465002651 catalytic residues [active] 446465002652 metal binding site [ion binding]; metal-binding site 446465002653 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 446465002654 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 446465002655 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 446465002656 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 446465002657 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 446465002658 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 446465002659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465002660 motif II; other site 446465002661 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465002662 hydrophobic ligand binding site; other site 446465002663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465002664 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446465002665 putative substrate translocation pore; other site 446465002666 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 446465002667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465002668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465002669 Walker A/P-loop; other site 446465002670 Walker A/P-loop; other site 446465002671 ATP binding site [chemical binding]; other site 446465002672 ATP binding site [chemical binding]; other site 446465002673 ABC transporter; Region: ABC_tran; pfam00005 446465002674 Q-loop/lid; other site 446465002675 ABC transporter signature motif; other site 446465002676 Walker B; other site 446465002677 D-loop; other site 446465002678 H-loop/switch region; other site 446465002679 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446465002680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465002681 S-adenosylmethionine binding site [chemical binding]; other site 446465002682 aspartate aminotransferase; Provisional; Region: PRK05764 446465002683 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465002684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465002685 homodimer interface [polypeptide binding]; other site 446465002686 catalytic residue [active] 446465002687 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 446465002688 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446465002689 DNA binding site [nucleotide binding] 446465002690 active site 446465002691 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 446465002692 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 446465002693 AlkA N-terminal domain; Region: AlkA_N; pfam06029 446465002694 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 446465002695 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446465002696 minor groove reading motif; other site 446465002697 helix-hairpin-helix signature motif; other site 446465002698 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 446465002699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465002700 S-adenosylmethionine binding site [chemical binding]; other site 446465002701 trigger factor; Provisional; Region: tig; PRK01490 446465002702 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446465002703 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 446465002704 RibD C-terminal domain; Region: RibD_C; cl17279 446465002705 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446465002706 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446465002707 NlpC/P60 family; Region: NLPC_P60; pfam00877 446465002708 Clp protease; Region: CLP_protease; pfam00574 446465002709 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446465002710 oligomer interface [polypeptide binding]; other site 446465002711 active site residues [active] 446465002712 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 446465002713 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446465002714 oligomer interface [polypeptide binding]; other site 446465002715 active site residues [active] 446465002716 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 446465002717 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 446465002718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465002719 Walker A motif; other site 446465002720 ATP binding site [chemical binding]; other site 446465002721 Walker B motif; other site 446465002722 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 446465002723 chorismate mutase; Provisional; Region: PRK09239 446465002724 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446465002725 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446465002726 molybdopterin cofactor binding site; other site 446465002727 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446465002728 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 446465002729 molybdopterin cofactor binding site; other site 446465002730 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 446465002731 4Fe-4S binding domain; Region: Fer4; pfam00037 446465002732 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 446465002733 selenophosphate synthetase; Provisional; Region: PRK00943 446465002734 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 446465002735 dimerization interface [polypeptide binding]; other site 446465002736 putative ATP binding site [chemical binding]; other site 446465002737 selenocysteine synthase; Provisional; Region: PRK04311 446465002738 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446465002739 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465002740 catalytic residue [active] 446465002741 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 446465002742 translation initiation factor IF-2 subunit gamma; Validated; Region: PRK04000 446465002743 G1 box; other site 446465002744 putative GEF interaction site [polypeptide binding]; other site 446465002745 GTP/Mg2+ binding site [chemical binding]; other site 446465002746 Switch I region; other site 446465002747 G2 box; other site 446465002748 G3 box; other site 446465002749 Switch II region; other site 446465002750 G4 box; other site 446465002751 G5 box; other site 446465002752 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 446465002753 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 446465002754 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 446465002755 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 446465002756 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465002757 active site 446465002758 HIGH motif; other site 446465002759 nucleotide binding site [chemical binding]; other site 446465002760 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465002761 active site 446465002762 KMSKS motif; other site 446465002763 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 446465002764 tRNA binding surface [nucleotide binding]; other site 446465002765 anticodon binding site; other site 446465002766 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 446465002767 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446465002768 active site 446465002769 metal binding site [ion binding]; metal-binding site 446465002770 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446465002771 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446465002772 dimer interface [polypeptide binding]; other site 446465002773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465002774 catalytic residue [active] 446465002775 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 446465002776 Peptidase M60-like family; Region: M60-like; pfam13402 446465002777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465002778 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446465002779 Walker A/P-loop; other site 446465002780 ATP binding site [chemical binding]; other site 446465002781 Q-loop/lid; other site 446465002782 ABC transporter signature motif; other site 446465002783 Walker B; other site 446465002784 D-loop; other site 446465002785 H-loop/switch region; other site 446465002786 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 446465002787 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 446465002788 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 446465002789 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 446465002790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465002791 dimerization interface [polypeptide binding]; other site 446465002792 putative DNA binding site [nucleotide binding]; other site 446465002793 putative Zn2+ binding site [ion binding]; other site 446465002794 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 446465002795 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 446465002796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465002797 NAD(P) binding site [chemical binding]; other site 446465002798 active site 446465002799 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465002800 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465002801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465002802 Walker A/P-loop; other site 446465002803 ATP binding site [chemical binding]; other site 446465002804 Q-loop/lid; other site 446465002805 ABC transporter signature motif; other site 446465002806 Walker B; other site 446465002807 D-loop; other site 446465002808 H-loop/switch region; other site 446465002809 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446465002810 catalytic loop [active] 446465002811 iron binding site [ion binding]; other site 446465002812 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 446465002813 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446465002814 HIGH motif; other site 446465002815 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446465002816 active site 446465002817 KMSKS motif; other site 446465002818 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 446465002819 tRNA binding surface [nucleotide binding]; other site 446465002820 anticodon binding site; other site 446465002821 Proteins of 100 residues with WXG; Region: WXG100; cl02005 446465002822 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 446465002823 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446465002824 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446465002825 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 446465002826 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 446465002827 active site 446465002828 multimer interface [polypeptide binding]; other site 446465002829 signal recognition particle protein; Provisional; Region: PRK10867 446465002830 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 446465002831 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 446465002832 P loop; other site 446465002833 GTP binding site [chemical binding]; other site 446465002834 Signal peptide binding domain; Region: SRP_SPB; pfam02978 446465002835 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446465002836 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446465002837 active site 446465002838 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 446465002839 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 446465002840 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 446465002841 RimM N-terminal domain; Region: RimM; pfam01782 446465002842 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 446465002843 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 446465002844 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 446465002845 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446465002846 Catalytic site [active] 446465002847 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 446465002848 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446465002849 Catalytic site [active] 446465002850 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 446465002851 RNA/DNA hybrid binding site [nucleotide binding]; other site 446465002852 active site 446465002853 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 446465002854 hypothetical protein; Reviewed; Region: PRK12497 446465002855 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 446465002856 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 446465002857 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 446465002858 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 446465002859 DNA protecting protein DprA; Region: dprA; TIGR00732 446465002860 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 446465002861 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 446465002862 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446465002863 active site 446465002864 DNA binding site [nucleotide binding] 446465002865 Int/Topo IB signature motif; other site 446465002866 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446465002867 Peptidase family M23; Region: Peptidase_M23; pfam01551 446465002868 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 446465002869 rRNA interaction site [nucleotide binding]; other site 446465002870 S8 interaction site; other site 446465002871 putative laminin-1 binding site; other site 446465002872 elongation factor Ts; Provisional; Region: tsf; PRK09377 446465002873 Elongation factor TS; Region: EF_TS; pfam00889 446465002874 Elongation factor TS; Region: EF_TS; pfam00889 446465002875 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 446465002876 putative nucleotide binding site [chemical binding]; other site 446465002877 uridine monophosphate binding site [chemical binding]; other site 446465002878 homohexameric interface [polypeptide binding]; other site 446465002879 ribosome recycling factor; Reviewed; Region: frr; PRK00083 446465002880 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 446465002881 hinge region; other site 446465002882 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 446465002883 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 446465002884 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 446465002885 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446465002886 FeS/SAM binding site; other site 446465002887 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 446465002888 DivIVA domain; Region: DivI1A_domain; TIGR03544 446465002889 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 446465002890 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 446465002891 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 446465002892 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 446465002893 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 446465002894 active site 446465002895 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 446465002896 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 446465002897 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 446465002898 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 446465002899 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 446465002900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465002901 Coenzyme A binding pocket [chemical binding]; other site 446465002902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465002903 S-adenosylmethionine binding site [chemical binding]; other site 446465002904 AAA domain; Region: AAA_17; pfam13207 446465002905 AAA domain; Region: AAA_18; pfam13238 446465002906 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446465002907 prolyl-tRNA synthetase; Provisional; Region: PRK09194 446465002908 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 446465002909 dimer interface [polypeptide binding]; other site 446465002910 motif 1; other site 446465002911 active site 446465002912 motif 2; other site 446465002913 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 446465002914 putative deacylase active site [active] 446465002915 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446465002916 active site 446465002917 motif 3; other site 446465002918 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 446465002919 anticodon binding site; other site 446465002920 ribosome maturation protein RimP; Reviewed; Region: PRK00092 446465002921 Sm and related proteins; Region: Sm_like; cl00259 446465002922 heptamer interface [polypeptide binding]; other site 446465002923 Sm1 motif; other site 446465002924 hexamer interface [polypeptide binding]; other site 446465002925 RNA binding site [nucleotide binding]; other site 446465002926 Sm2 motif; other site 446465002927 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 446465002928 NusA N-terminal domain; Region: NusA_N; pfam08529 446465002929 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 446465002930 RNA binding site [nucleotide binding]; other site 446465002931 homodimer interface [polypeptide binding]; other site 446465002932 NusA-like KH domain; Region: KH_5; pfam13184 446465002933 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 446465002934 G-X-X-G motif; other site 446465002935 Protein of unknown function (DUF448); Region: DUF448; pfam04296 446465002936 putative RNA binding cleft [nucleotide binding]; other site 446465002937 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446465002938 translation initiation factor IF-2; Region: IF-2; TIGR00487 446465002939 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446465002940 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 446465002941 G1 box; other site 446465002942 putative GEF interaction site [polypeptide binding]; other site 446465002943 GTP/Mg2+ binding site [chemical binding]; other site 446465002944 Switch I region; other site 446465002945 G2 box; other site 446465002946 G3 box; other site 446465002947 Switch II region; other site 446465002948 G4 box; other site 446465002949 G5 box; other site 446465002950 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 446465002951 Translation-initiation factor 2; Region: IF-2; pfam11987 446465002952 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 446465002953 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 446465002954 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 446465002955 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 446465002956 RNA binding site [nucleotide binding]; other site 446465002957 active site 446465002958 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 446465002959 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 446465002960 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 446465002961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 446465002962 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446465002963 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 446465002964 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 446465002965 active site 446465002966 Riboflavin kinase; Region: Flavokinase; pfam01687 446465002967 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 446465002968 16S/18S rRNA binding site [nucleotide binding]; other site 446465002969 S13e-L30e interaction site [polypeptide binding]; other site 446465002970 25S rRNA binding site [nucleotide binding]; other site 446465002971 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 446465002972 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 446465002973 oligomer interface [polypeptide binding]; other site 446465002974 RNA binding site [nucleotide binding]; other site 446465002975 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 446465002976 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 446465002977 RNase E interface [polypeptide binding]; other site 446465002978 trimer interface [polypeptide binding]; other site 446465002979 active site 446465002980 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 446465002981 putative nucleic acid binding region [nucleotide binding]; other site 446465002982 G-X-X-G motif; other site 446465002983 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 446465002984 RNA binding site [nucleotide binding]; other site 446465002985 domain interface; other site 446465002986 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446465002987 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 446465002988 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446465002989 dihydrodipicolinate reductase; Provisional; Region: PRK00048 446465002990 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 446465002991 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 446465002992 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 446465002993 AzlC protein; Region: AzlC; pfam03591 446465002994 putative phosphatase; Provisional; Region: PRK11587 446465002995 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 446465002996 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 446465002997 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 446465002998 active site 446465002999 dimer interface [polypeptide binding]; other site 446465003000 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 446465003001 Ligand Binding Site [chemical binding]; other site 446465003002 Molecular Tunnel; other site 446465003003 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 446465003004 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446465003005 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 446465003006 dimer interface [polypeptide binding]; other site 446465003007 active site 446465003008 catalytic residue [active] 446465003009 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 446465003010 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446465003011 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 446465003012 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 446465003013 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 446465003014 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446465003015 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 446465003016 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 446465003017 Competence-damaged protein; Region: CinA; pfam02464 446465003018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465003019 non-specific DNA binding site [nucleotide binding]; other site 446465003020 salt bridge; other site 446465003021 sequence-specific DNA binding site [nucleotide binding]; other site 446465003022 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 446465003023 recombinase A; Provisional; Region: recA; PRK09354 446465003024 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 446465003025 hexamer interface [polypeptide binding]; other site 446465003026 Walker A motif; other site 446465003027 ATP binding site [chemical binding]; other site 446465003028 Walker B motif; other site 446465003029 RecX family; Region: RecX; pfam02631 446465003030 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 446465003031 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 446465003032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446465003033 FeS/SAM binding site; other site 446465003034 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 446465003035 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 446465003036 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 446465003037 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 446465003038 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 446465003039 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 446465003040 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 446465003041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465003042 S-adenosylmethionine binding site [chemical binding]; other site 446465003043 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 446465003044 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 446465003045 HflX GTPase family; Region: HflX; cd01878 446465003046 G1 box; other site 446465003047 GTP/Mg2+ binding site [chemical binding]; other site 446465003048 Switch I region; other site 446465003049 G2 box; other site 446465003050 G3 box; other site 446465003051 Switch II region; other site 446465003052 G4 box; other site 446465003053 G5 box; other site 446465003054 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 446465003055 DEAD/DEAH box helicase; Region: DEAD; pfam00270 446465003056 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 446465003057 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 446465003058 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 446465003059 LexA repressor; Validated; Region: PRK00215 446465003060 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 446465003061 Catalytic site [active] 446465003062 cell division suppressor protein YneA; Provisional; Region: PRK14125 446465003063 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 446465003064 ATP cone domain; Region: ATP-cone; pfam03477 446465003065 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446465003066 Part of AAA domain; Region: AAA_19; pfam13245 446465003067 Family description; Region: UvrD_C_2; pfam13538 446465003068 PAC2 family; Region: PAC2; pfam09754 446465003069 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446465003070 DNA-binding site [nucleotide binding]; DNA binding site 446465003071 RNA-binding motif; other site 446465003072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446465003073 DNA polymerase IV; Validated; Region: PRK03858 446465003074 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 446465003075 active site 446465003076 DNA binding site [nucleotide binding] 446465003077 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 446465003078 cell division protein MraZ; Reviewed; Region: PRK00326 446465003079 MraZ protein; Region: MraZ; pfam02381 446465003080 MraZ protein; Region: MraZ; pfam02381 446465003081 MraW methylase family; Region: Methyltransf_5; cl17771 446465003082 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 446465003083 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 446465003084 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446465003085 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446465003086 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 446465003087 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446465003088 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446465003089 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 446465003090 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446465003091 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446465003092 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446465003093 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 446465003094 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 446465003095 Mg++ binding site [ion binding]; other site 446465003096 putative catalytic motif [active] 446465003097 putative substrate binding site [chemical binding]; other site 446465003098 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 446465003099 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446465003100 cell division protein FtsW; Region: ftsW; TIGR02614 446465003101 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 446465003102 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 446465003103 active site 446465003104 homodimer interface [polypeptide binding]; other site 446465003105 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 446465003106 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446465003107 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446465003108 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446465003109 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 446465003110 Cell division protein FtsQ; Region: FtsQ; pfam03799 446465003111 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 446465003112 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 446465003113 nucleotide binding site [chemical binding]; other site 446465003114 SulA interaction site; other site 446465003115 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 446465003116 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 446465003117 Protein of unknown function (DUF552); Region: DUF552; pfam04472 446465003118 DivIVA domain; Region: DivI1A_domain; TIGR03544 446465003119 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 446465003120 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 446465003121 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446465003122 RNA binding surface [nucleotide binding]; other site 446465003123 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 446465003124 active site 446465003125 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446465003126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465003127 Coenzyme A binding pocket [chemical binding]; other site 446465003128 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 446465003129 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 446465003130 active site 446465003131 catalytic site [active] 446465003132 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 446465003133 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 446465003134 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465003135 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465003136 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446465003137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446465003138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465003139 conserved gate region; other site 446465003140 dimer interface [polypeptide binding]; other site 446465003141 putative PBP binding loops; other site 446465003142 ABC-ATPase subunit interface; other site 446465003143 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465003144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465003145 dimer interface [polypeptide binding]; other site 446465003146 conserved gate region; other site 446465003147 putative PBP binding loops; other site 446465003148 ABC-ATPase subunit interface; other site 446465003149 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 446465003150 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 446465003151 active site 446465003152 PHP Thumb interface [polypeptide binding]; other site 446465003153 metal binding site [ion binding]; metal-binding site 446465003154 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 446465003155 generic binding surface II; other site 446465003156 generic binding surface I; other site 446465003157 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446465003158 putative catalytic site [active] 446465003159 putative metal binding site [ion binding]; other site 446465003160 putative phosphate binding site [ion binding]; other site 446465003161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446465003162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446465003163 active site 446465003164 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 446465003165 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 446465003166 active site 446465003167 ADP/pyrophosphate binding site [chemical binding]; other site 446465003168 dimerization interface [polypeptide binding]; other site 446465003169 allosteric effector site; other site 446465003170 fructose-1,6-bisphosphate binding site; other site 446465003171 metabolite-proton symporter; Region: 2A0106; TIGR00883 446465003172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465003173 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 446465003174 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 446465003175 active site 446465003176 dimer interface [polypeptide binding]; other site 446465003177 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 446465003178 dimer interface [polypeptide binding]; other site 446465003179 active site 446465003180 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446465003181 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465003182 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465003183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465003184 dimer interface [polypeptide binding]; other site 446465003185 conserved gate region; other site 446465003186 putative PBP binding loops; other site 446465003187 ABC-ATPase subunit interface; other site 446465003188 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 446465003189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465003190 dimer interface [polypeptide binding]; other site 446465003191 conserved gate region; other site 446465003192 putative PBP binding loops; other site 446465003193 ABC-ATPase subunit interface; other site 446465003194 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465003195 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465003196 Walker A/P-loop; other site 446465003197 ATP binding site [chemical binding]; other site 446465003198 Q-loop/lid; other site 446465003199 ABC transporter signature motif; other site 446465003200 Walker B; other site 446465003201 D-loop; other site 446465003202 H-loop/switch region; other site 446465003203 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446465003204 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465003205 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465003206 Walker A/P-loop; other site 446465003207 ATP binding site [chemical binding]; other site 446465003208 Q-loop/lid; other site 446465003209 ABC transporter signature motif; other site 446465003210 Walker B; other site 446465003211 D-loop; other site 446465003212 H-loop/switch region; other site 446465003213 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465003214 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 446465003215 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 446465003216 G1 box; other site 446465003217 putative GEF interaction site [polypeptide binding]; other site 446465003218 GTP/Mg2+ binding site [chemical binding]; other site 446465003219 Switch I region; other site 446465003220 G2 box; other site 446465003221 G3 box; other site 446465003222 Switch II region; other site 446465003223 G4 box; other site 446465003224 G5 box; other site 446465003225 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 446465003226 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 446465003227 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 446465003228 Ferredoxin [Energy production and conversion]; Region: COG1146 446465003229 4Fe-4S binding domain; Region: Fer4; pfam00037 446465003230 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 446465003231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465003232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465003233 homodimer interface [polypeptide binding]; other site 446465003234 catalytic residue [active] 446465003235 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 446465003236 dimer interface [polypeptide binding]; other site 446465003237 Citrate synthase; Region: Citrate_synt; pfam00285 446465003238 active site 446465003239 citrylCoA binding site [chemical binding]; other site 446465003240 NADH binding [chemical binding]; other site 446465003241 cationic pore residues; other site 446465003242 oxalacetate/citrate binding site [chemical binding]; other site 446465003243 coenzyme A binding site [chemical binding]; other site 446465003244 catalytic triad [active] 446465003245 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 446465003246 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 446465003247 putative trimer interface [polypeptide binding]; other site 446465003248 putative CoA binding site [chemical binding]; other site 446465003249 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 446465003250 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 446465003251 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 446465003252 metal binding site [ion binding]; metal-binding site 446465003253 putative dimer interface [polypeptide binding]; other site 446465003254 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 446465003255 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 446465003256 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 446465003257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446465003258 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 446465003259 Domain of unknown function DUF59; Region: DUF59; cl00941 446465003260 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 446465003261 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446465003262 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 446465003263 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 446465003264 MgtE intracellular N domain; Region: MgtE_N; smart00924 446465003265 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 446465003266 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 446465003267 proline aminopeptidase P II; Provisional; Region: PRK10879 446465003268 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 446465003269 active site 446465003270 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 446465003271 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 446465003272 active site 446465003273 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 446465003274 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446465003275 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465003276 ATP binding site [chemical binding]; other site 446465003277 Mg++ binding site [ion binding]; other site 446465003278 motif III; other site 446465003279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465003280 nucleotide binding region [chemical binding]; other site 446465003281 ATP-binding site [chemical binding]; other site 446465003282 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 446465003283 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446465003284 active site 446465003285 metal binding site [ion binding]; metal-binding site 446465003286 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 446465003287 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465003288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465003289 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446465003290 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446465003291 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446465003292 Part of AAA domain; Region: AAA_19; pfam13245 446465003293 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446465003294 Phosphotransferase enzyme family; Region: APH; pfam01636 446465003295 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446465003296 substrate binding site [chemical binding]; other site 446465003297 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 446465003298 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 446465003299 putative NADH binding site [chemical binding]; other site 446465003300 putative active site [active] 446465003301 nudix motif; other site 446465003302 putative metal binding site [ion binding]; other site 446465003303 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446465003304 Part of AAA domain; Region: AAA_19; pfam13245 446465003305 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446465003306 Family description; Region: UvrD_C_2; pfam13538 446465003307 HRDC domain; Region: HRDC; pfam00570 446465003308 Transcription factor WhiB; Region: Whib; pfam02467 446465003309 Protein of unknown function DUF45; Region: DUF45; cl00636 446465003310 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446465003311 nudix motif; other site 446465003312 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 446465003313 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 446465003314 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 446465003315 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 446465003316 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465003317 motif II; other site 446465003318 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 446465003319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465003320 Walker A/P-loop; other site 446465003321 ATP binding site [chemical binding]; other site 446465003322 Q-loop/lid; other site 446465003323 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446465003324 ABC transporter; Region: ABC_tran_2; pfam12848 446465003325 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446465003326 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465003327 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 446465003328 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465003329 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465003330 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 446465003331 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 446465003332 active site 446465003333 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 446465003334 catalytic triad [active] 446465003335 dimer interface [polypeptide binding]; other site 446465003336 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446465003337 active site 446465003338 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 446465003339 apolar tunnel; other site 446465003340 heme binding site [chemical binding]; other site 446465003341 dimerization interface [polypeptide binding]; other site 446465003342 Mechanosensitive ion channel; Region: MS_channel; pfam00924 446465003343 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 446465003344 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 446465003345 Zn binding site [ion binding]; other site 446465003346 Protein of unknown function (DUF402); Region: DUF402; pfam04167 446465003347 Fatty acid desaturase; Region: FA_desaturase; pfam00487 446465003348 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 446465003349 putative di-iron ligands [ion binding]; other site 446465003350 Histidine kinase; Region: HisKA_3; pfam07730 446465003351 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446465003352 Mg2+ binding site [ion binding]; other site 446465003353 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465003354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465003355 active site 446465003356 phosphorylation site [posttranslational modification] 446465003357 intermolecular recognition site; other site 446465003358 dimerization interface [polypeptide binding]; other site 446465003359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446465003360 DNA binding residues [nucleotide binding] 446465003361 dimerization interface [polypeptide binding]; other site 446465003362 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446465003363 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465003364 active site 446465003365 ATP binding site [chemical binding]; other site 446465003366 substrate binding site [chemical binding]; other site 446465003367 activation loop (A-loop); other site 446465003368 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465003369 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465003370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465003371 Walker A/P-loop; other site 446465003372 ATP binding site [chemical binding]; other site 446465003373 Q-loop/lid; other site 446465003374 ABC transporter signature motif; other site 446465003375 Walker B; other site 446465003376 D-loop; other site 446465003377 H-loop/switch region; other site 446465003378 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465003379 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465003380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465003381 ABC transporter signature motif; other site 446465003382 Walker B; other site 446465003383 D-loop; other site 446465003384 H-loop/switch region; other site 446465003385 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 446465003386 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 446465003387 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 446465003388 putative DNA binding site [nucleotide binding]; other site 446465003389 catalytic residue [active] 446465003390 putative H2TH interface [polypeptide binding]; other site 446465003391 putative catalytic residues [active] 446465003392 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446465003393 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446465003394 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465003395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465003396 DNA binding site [nucleotide binding] 446465003397 domain linker motif; other site 446465003398 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465003399 dimerization interface [polypeptide binding]; other site 446465003400 ligand binding site [chemical binding]; other site 446465003401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 446465003402 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 446465003403 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446465003404 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 446465003405 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 446465003406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465003407 Coenzyme A binding pocket [chemical binding]; other site 446465003408 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 446465003409 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 446465003410 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465003411 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446465003412 Walker A/P-loop; other site 446465003413 ATP binding site [chemical binding]; other site 446465003414 Q-loop/lid; other site 446465003415 ABC transporter signature motif; other site 446465003416 Walker B; other site 446465003417 D-loop; other site 446465003418 H-loop/switch region; other site 446465003419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465003420 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 446465003421 Walker A/P-loop; other site 446465003422 ATP binding site [chemical binding]; other site 446465003423 Q-loop/lid; other site 446465003424 ABC transporter signature motif; other site 446465003425 Walker B; other site 446465003426 D-loop; other site 446465003427 H-loop/switch region; other site 446465003428 Cobalt transport protein; Region: CbiQ; cl00463 446465003429 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 446465003430 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 446465003431 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 446465003432 active site 446465003433 Zn binding site [ion binding]; other site 446465003434 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 446465003435 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446465003436 putative catalytic site [active] 446465003437 putative metal binding site [ion binding]; other site 446465003438 putative phosphate binding site [ion binding]; other site 446465003439 putative catalytic site [active] 446465003440 putative phosphate binding site [ion binding]; other site 446465003441 putative metal binding site [ion binding]; other site 446465003442 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446465003443 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 446465003444 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 446465003445 putative ADP-binding pocket [chemical binding]; other site 446465003446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446465003447 Transposase; Region: DEDD_Tnp_IS110; pfam01548 446465003448 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 446465003449 Helix-turn-helix domain; Region: HTH_28; pfam13518 446465003450 Winged helix-turn helix; Region: HTH_29; pfam13551 446465003451 Homeodomain-like domain; Region: HTH_32; pfam13565 446465003452 Integrase core domain; Region: rve; pfam00665 446465003453 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 446465003454 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465003455 active site 446465003456 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465003457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465003458 active site 446465003459 phosphorylation site [posttranslational modification] 446465003460 intermolecular recognition site; other site 446465003461 dimerization interface [polypeptide binding]; other site 446465003462 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446465003463 DNA binding residues [nucleotide binding] 446465003464 dimerization interface [polypeptide binding]; other site 446465003465 Putative sensor; Region: Sensor; pfam13796 446465003466 Histidine kinase; Region: HisKA_3; pfam07730 446465003467 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446465003468 ATP binding site [chemical binding]; other site 446465003469 Mg2+ binding site [ion binding]; other site 446465003470 G-X-G motif; other site 446465003471 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446465003472 active site 446465003473 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465003474 dimerization interface [polypeptide binding]; other site 446465003475 putative DNA binding site [nucleotide binding]; other site 446465003476 putative Zn2+ binding site [ion binding]; other site 446465003477 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465003478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465003479 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446465003480 NAD(P) binding site [chemical binding]; other site 446465003481 active site 446465003482 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465003483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465003484 Methyltransferase domain; Region: Methyltransf_11; pfam08241 446465003485 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 446465003486 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 446465003487 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 446465003488 active site 446465003489 substrate binding site [chemical binding]; other site 446465003490 FMN binding site [chemical binding]; other site 446465003491 putative catalytic residues [active] 446465003492 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465003493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465003494 DNA-binding site [nucleotide binding]; DNA binding site 446465003495 FCD domain; Region: FCD; pfam07729 446465003496 citrate synthase; Provisional; Region: PRK14033 446465003497 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 446465003498 oxalacetate binding site [chemical binding]; other site 446465003499 citrylCoA binding site [chemical binding]; other site 446465003500 coenzyme A binding site [chemical binding]; other site 446465003501 catalytic triad [active] 446465003502 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 446465003503 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446465003504 tetramer interface [polypeptide binding]; other site 446465003505 active site 446465003506 Mg2+/Mn2+ binding site [ion binding]; other site 446465003507 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 446465003508 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446465003509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465003510 DNA-binding site [nucleotide binding]; DNA binding site 446465003511 FCD domain; Region: FCD; pfam07729 446465003512 PKD domain; Region: PKD; pfam00801 446465003513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446465003514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465003515 Coenzyme A binding pocket [chemical binding]; other site 446465003516 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 446465003517 nucleotide binding site/active site [active] 446465003518 HIT family signature motif; other site 446465003519 catalytic residue [active] 446465003520 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 446465003521 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 446465003522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 446465003523 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 446465003524 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465003525 nucleotide binding site [chemical binding]; other site 446465003526 heat shock protein GrpE; Provisional; Region: PRK14140 446465003527 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 446465003528 dimer interface [polypeptide binding]; other site 446465003529 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 446465003530 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 446465003531 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446465003532 HSP70 interaction site [polypeptide binding]; other site 446465003533 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 446465003534 substrate binding site [polypeptide binding]; other site 446465003535 dimer interface [polypeptide binding]; other site 446465003536 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 446465003537 DNA binding residues [nucleotide binding] 446465003538 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446465003539 putative dimer interface [polypeptide binding]; other site 446465003540 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465003541 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465003542 Uncharacterized conserved protein [Function unknown]; Region: COG0398 446465003543 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446465003544 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465003545 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 446465003546 putative ADP-binding pocket [chemical binding]; other site 446465003547 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 446465003548 substrate binding site [chemical binding]; other site 446465003549 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446465003550 IDEAL domain; Region: IDEAL; cl07452 446465003551 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446465003552 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 446465003553 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446465003554 active site 446465003555 catalytic site [active] 446465003556 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446465003557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465003558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465003559 dimer interface [polypeptide binding]; other site 446465003560 conserved gate region; other site 446465003561 putative PBP binding loops; other site 446465003562 ABC-ATPase subunit interface; other site 446465003563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465003564 dimer interface [polypeptide binding]; other site 446465003565 conserved gate region; other site 446465003566 ABC-ATPase subunit interface; other site 446465003567 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465003568 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465003569 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465003570 DNA binding site [nucleotide binding] 446465003571 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465003572 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 446465003573 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 446465003574 active site 446465003575 HIGH motif; other site 446465003576 dimer interface [polypeptide binding]; other site 446465003577 KMSKS motif; other site 446465003578 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446465003579 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446465003580 dimer interface [polypeptide binding]; other site 446465003581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465003582 catalytic residue [active] 446465003583 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 446465003584 serine O-acetyltransferase; Region: cysE; TIGR01172 446465003585 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 446465003586 trimer interface [polypeptide binding]; other site 446465003587 active site 446465003588 substrate binding site [chemical binding]; other site 446465003589 CoA binding site [chemical binding]; other site 446465003590 NAD-dependent deacetylase; Provisional; Region: PRK00481 446465003591 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 446465003592 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465003593 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465003594 active site 446465003595 catalytic tetrad [active] 446465003596 Amidinotransferase; Region: Amidinotransf; cl12043 446465003597 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446465003598 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446465003599 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 446465003600 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446465003601 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 446465003602 lipoyl attachment site [posttranslational modification]; other site 446465003603 glycine dehydrogenase; Provisional; Region: PRK05367 446465003604 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 446465003605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465003606 tetramer interface [polypeptide binding]; other site 446465003607 catalytic residue [active] 446465003608 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 446465003609 tetramer interface [polypeptide binding]; other site 446465003610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465003611 catalytic residue [active] 446465003612 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 446465003613 substrate binding site [chemical binding]; other site 446465003614 THF binding site; other site 446465003615 zinc-binding site [ion binding]; other site 446465003616 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465003617 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 446465003618 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 446465003619 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 446465003620 catalytic triad [active] 446465003621 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 446465003622 Protein of unknown function (DUF952); Region: DUF952; pfam06108 446465003623 Predicted acetyltransferase [General function prediction only]; Region: COG2388 446465003624 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446465003625 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446465003626 active site 446465003627 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446465003628 Amidase; Region: Amidase; cl11426 446465003629 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446465003630 RNA binding surface [nucleotide binding]; other site 446465003631 Protease prsW family; Region: PrsW-protease; pfam13367 446465003632 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 446465003633 Clp amino terminal domain; Region: Clp_N; pfam02861 446465003634 Clp amino terminal domain; Region: Clp_N; pfam02861 446465003635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465003636 Walker A motif; other site 446465003637 ATP binding site [chemical binding]; other site 446465003638 Walker B motif; other site 446465003639 arginine finger; other site 446465003640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465003641 Walker A motif; other site 446465003642 ATP binding site [chemical binding]; other site 446465003643 Walker B motif; other site 446465003644 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446465003645 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465003646 active site 446465003647 HIGH motif; other site 446465003648 nucleotide binding site [chemical binding]; other site 446465003649 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 446465003650 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465003651 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 446465003652 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465003653 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465003654 active site 446465003655 KMSKS motif; other site 446465003656 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 446465003657 tRNA binding surface [nucleotide binding]; other site 446465003658 Predicted permeases [General function prediction only]; Region: COG0679 446465003659 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 446465003660 tetramerization interface [polypeptide binding]; other site 446465003661 active site 446465003662 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 446465003663 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465003664 ATP binding site [chemical binding]; other site 446465003665 putative Mg++ binding site [ion binding]; other site 446465003666 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465003667 nucleotide binding region [chemical binding]; other site 446465003668 ATP-binding site [chemical binding]; other site 446465003669 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 446465003670 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 446465003671 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 446465003672 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446465003673 CoA binding site [chemical binding]; other site 446465003674 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446465003675 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446465003676 phosphate binding site [ion binding]; other site 446465003677 acetyl-CoA synthetase; Provisional; Region: PRK00174 446465003678 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 446465003679 active site 446465003680 CoA binding site [chemical binding]; other site 446465003681 acyl-activating enzyme (AAE) consensus motif; other site 446465003682 AMP binding site [chemical binding]; other site 446465003683 acetate binding site [chemical binding]; other site 446465003684 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446465003685 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465003686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465003687 active site 446465003688 phosphorylation site [posttranslational modification] 446465003689 intermolecular recognition site; other site 446465003690 dimerization interface [polypeptide binding]; other site 446465003691 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446465003692 DNA binding residues [nucleotide binding] 446465003693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 446465003694 Histidine kinase; Region: HisKA_3; pfam07730 446465003695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465003696 ATP binding site [chemical binding]; other site 446465003697 Mg2+ binding site [ion binding]; other site 446465003698 G-X-G motif; other site 446465003699 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465003700 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465003701 DNA binding site [nucleotide binding] 446465003702 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465003703 dimerization interface [polypeptide binding]; other site 446465003704 ligand binding site [chemical binding]; other site 446465003705 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 446465003706 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465003707 active site 446465003708 HIGH motif; other site 446465003709 nucleotide binding site [chemical binding]; other site 446465003710 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 446465003711 KMSKS motif; other site 446465003712 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446465003713 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 446465003714 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 446465003715 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446465003716 Predicted membrane protein [Function unknown]; Region: COG2364 446465003717 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 446465003718 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 446465003719 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446465003720 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 446465003721 Walker A/P-loop; other site 446465003722 ATP binding site [chemical binding]; other site 446465003723 Q-loop/lid; other site 446465003724 ABC transporter signature motif; other site 446465003725 Walker B; other site 446465003726 D-loop; other site 446465003727 H-loop/switch region; other site 446465003728 TOBE domain; Region: TOBE_2; pfam08402 446465003729 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 446465003730 active site 446465003731 catalytic residues [active] 446465003732 metal binding site [ion binding]; metal-binding site 446465003733 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 446465003734 dimer interface [polypeptide binding]; other site 446465003735 substrate binding site [chemical binding]; other site 446465003736 metal binding sites [ion binding]; metal-binding site 446465003737 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 446465003738 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 446465003739 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 446465003740 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 446465003741 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 446465003742 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446465003743 active site 446465003744 FtsH Extracellular; Region: FtsH_ext; pfam06480 446465003745 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 446465003746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465003747 Walker A motif; other site 446465003748 ATP binding site [chemical binding]; other site 446465003749 Walker B motif; other site 446465003750 arginine finger; other site 446465003751 Peptidase family M41; Region: Peptidase_M41; pfam01434 446465003752 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 446465003753 homodecamer interface [polypeptide binding]; other site 446465003754 GTP cyclohydrolase I; Provisional; Region: PLN03044 446465003755 active site 446465003756 putative catalytic site residues [active] 446465003757 zinc binding site [ion binding]; other site 446465003758 GTP-CH-I/GFRP interaction surface; other site 446465003759 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 446465003760 dihydropteroate synthase; Region: DHPS; TIGR01496 446465003761 substrate binding pocket [chemical binding]; other site 446465003762 dimer interface [polypeptide binding]; other site 446465003763 inhibitor binding site; inhibition site 446465003764 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 446465003765 homooctamer interface [polypeptide binding]; other site 446465003766 active site 446465003767 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 446465003768 catalytic center binding site [active] 446465003769 ATP binding site [chemical binding]; other site 446465003770 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 446465003771 Bacterial PH domain; Region: DUF304; cl01348 446465003772 Bacterial PH domain; Region: DUF304; pfam03703 446465003773 Predicted membrane protein [Function unknown]; Region: COG3428 446465003774 Bacterial PH domain; Region: DUF304; cl01348 446465003775 Bacterial PH domain; Region: DUF304; pfam03703 446465003776 Rossmann-like domain; Region: Rossmann-like; pfam10727 446465003777 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 446465003778 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465003779 active site 446465003780 nucleotide binding site [chemical binding]; other site 446465003781 HIGH motif; other site 446465003782 KMSKS motif; other site 446465003783 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 446465003784 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 446465003785 dimer interface [polypeptide binding]; other site 446465003786 putative anticodon binding site; other site 446465003787 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446465003788 motif 1; other site 446465003789 dimer interface [polypeptide binding]; other site 446465003790 active site 446465003791 motif 2; other site 446465003792 motif 3; other site 446465003793 Lsr2; Region: Lsr2; pfam11774 446465003794 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 446465003795 active site 446465003796 catalytic residues [active] 446465003797 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 446465003798 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 446465003799 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 446465003800 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 446465003801 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 446465003802 Cysteine-rich domain; Region: CCG; pfam02754 446465003803 Cysteine-rich domain; Region: CCG; pfam02754 446465003804 malate:quinone oxidoreductase; Validated; Region: PRK05257 446465003805 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 446465003806 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 446465003807 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 446465003808 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465003809 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465003810 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465003811 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465003812 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 446465003813 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 446465003814 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465003815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465003816 DNA-binding site [nucleotide binding]; DNA binding site 446465003817 FCD domain; Region: FCD; pfam07729 446465003818 Clp protease ATP binding subunit; Region: clpC; CHL00095 446465003819 Clp amino terminal domain; Region: Clp_N; pfam02861 446465003820 Clp amino terminal domain; Region: Clp_N; pfam02861 446465003821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465003822 Walker A motif; other site 446465003823 ATP binding site [chemical binding]; other site 446465003824 Walker B motif; other site 446465003825 arginine finger; other site 446465003826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465003827 Walker A motif; other site 446465003828 ATP binding site [chemical binding]; other site 446465003829 Walker B motif; other site 446465003830 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446465003831 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446465003832 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446465003833 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 446465003834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465003835 Coenzyme A binding pocket [chemical binding]; other site 446465003836 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446465003837 endonuclease III; Region: ENDO3c; smart00478 446465003838 minor groove reading motif; other site 446465003839 helix-hairpin-helix signature motif; other site 446465003840 substrate binding pocket [chemical binding]; other site 446465003841 active site 446465003842 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 446465003843 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 446465003844 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 446465003845 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 446465003846 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 446465003847 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 446465003848 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446465003849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446465003850 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 446465003851 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446465003852 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446465003853 catalytic residue [active] 446465003854 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 446465003855 FAD binding domain; Region: FAD_binding_4; pfam01565 446465003856 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 446465003857 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 446465003858 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446465003859 active site 446465003860 dimerization interface [polypeptide binding]; other site 446465003861 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465003862 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465003863 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446465003864 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446465003865 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446465003866 dimerization interface [polypeptide binding]; other site 446465003867 S-ribosylhomocysteinase; Provisional; Region: PRK02260 446465003868 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 446465003869 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 446465003870 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 446465003871 Predicted methyltransferases [General function prediction only]; Region: COG0313 446465003872 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 446465003873 putative SAM binding site [chemical binding]; other site 446465003874 putative homodimer interface [polypeptide binding]; other site 446465003875 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 446465003876 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 446465003877 active site 446465003878 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 446465003879 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 446465003880 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 446465003881 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 446465003882 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446465003883 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465003884 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446465003885 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446465003886 ABC transporter; Region: ABC_tran_2; pfam12848 446465003887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465003888 Walker A/P-loop; other site 446465003889 ATP binding site [chemical binding]; other site 446465003890 Q-loop/lid; other site 446465003891 ABC transporter signature motif; other site 446465003892 Walker B; other site 446465003893 D-loop; other site 446465003894 H-loop/switch region; other site 446465003895 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446465003896 MarR family; Region: MarR_2; pfam12802 446465003897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465003898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465003899 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 446465003900 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 446465003901 Substrate binding site; other site 446465003902 Mg++ binding site; other site 446465003903 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 446465003904 active site 446465003905 substrate binding site [chemical binding]; other site 446465003906 CoA binding site [chemical binding]; other site 446465003907 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 446465003908 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 446465003909 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446465003910 active site 446465003911 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 446465003912 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 446465003913 5S rRNA interface [nucleotide binding]; other site 446465003914 CTC domain interface [polypeptide binding]; other site 446465003915 L16 interface [polypeptide binding]; other site 446465003916 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 446465003917 putative active site [active] 446465003918 catalytic residue [active] 446465003919 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 446465003920 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 446465003921 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465003922 ATP binding site [chemical binding]; other site 446465003923 putative Mg++ binding site [ion binding]; other site 446465003924 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465003925 nucleotide binding region [chemical binding]; other site 446465003926 ATP-binding site [chemical binding]; other site 446465003927 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 446465003928 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 446465003929 homodimer interface [polypeptide binding]; other site 446465003930 metal binding site [ion binding]; metal-binding site 446465003931 enolase; Provisional; Region: eno; PRK00077 446465003932 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 446465003933 dimer interface [polypeptide binding]; other site 446465003934 metal binding site [ion binding]; metal-binding site 446465003935 substrate binding pocket [chemical binding]; other site 446465003936 Septum formation initiator; Region: DivIC; pfam04977 446465003937 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 446465003938 Protein of unknown function (DUF501); Region: DUF501; cl00652 446465003939 exopolyphosphatase; Region: exo_poly_only; TIGR03706 446465003940 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 446465003941 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446465003942 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 446465003943 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 446465003944 active site 446465003945 trimer interface [polypeptide binding]; other site 446465003946 allosteric site; other site 446465003947 active site lid [active] 446465003948 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 446465003949 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446465003950 MarR family; Region: MarR; pfam01047 446465003951 phosphoserine aminotransferase; Provisional; Region: PRK03080 446465003952 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465003953 catalytic residue [active] 446465003954 ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed; Region: ubiE; PRK00216 446465003955 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 446465003956 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446465003957 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446465003958 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446465003959 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446465003960 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465003961 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465003962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465003963 dimer interface [polypeptide binding]; other site 446465003964 conserved gate region; other site 446465003965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446465003966 ABC-ATPase subunit interface; other site 446465003967 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465003968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465003969 dimer interface [polypeptide binding]; other site 446465003970 conserved gate region; other site 446465003971 putative PBP binding loops; other site 446465003972 ABC-ATPase subunit interface; other site 446465003973 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465003974 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465003975 DNA binding site [nucleotide binding] 446465003976 domain linker motif; other site 446465003977 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465003978 ligand binding site [chemical binding]; other site 446465003979 dimerization interface [polypeptide binding]; other site 446465003980 putative methyltransferase; Provisional; Region: PRK10864 446465003981 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 446465003982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465003983 motif I; other site 446465003984 motif II; other site 446465003985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465003986 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 446465003987 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 446465003988 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 446465003989 ATP-NAD kinase; Region: NAD_kinase; pfam01513 446465003990 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 446465003991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465003992 Walker A/P-loop; other site 446465003993 ATP binding site [chemical binding]; other site 446465003994 Q-loop/lid; other site 446465003995 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 446465003996 ABC transporter signature motif; other site 446465003997 Walker B; other site 446465003998 D-loop; other site 446465003999 H-loop/switch region; other site 446465004000 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 446465004001 Thiamine pyrophosphokinase; Region: TPK; cl08415 446465004002 active site 446465004003 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 446465004004 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 446465004005 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 446465004006 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465004007 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465004008 CTP synthetase; Validated; Region: pyrG; PRK05380 446465004009 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 446465004010 Catalytic site [active] 446465004011 active site 446465004012 UTP binding site [chemical binding]; other site 446465004013 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 446465004014 active site 446465004015 putative oxyanion hole; other site 446465004016 catalytic triad [active] 446465004017 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446465004018 dimer interface [polypeptide binding]; other site 446465004019 active site 446465004020 ADP-ribose binding site [chemical binding]; other site 446465004021 nudix motif; other site 446465004022 metal binding site [ion binding]; metal-binding site 446465004023 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 446465004024 putative active site [active] 446465004025 putative substrate binding site [chemical binding]; other site 446465004026 catalytic site [active] 446465004027 HRDC domain; Region: HRDC; cl02578 446465004028 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 446465004029 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 446465004030 SelR domain; Region: SelR; pfam01641 446465004031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446465004032 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446465004033 RibD C-terminal domain; Region: RibD_C; cl17279 446465004034 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 446465004035 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 446465004036 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 446465004037 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 446465004038 catalytic site [active] 446465004039 active site 446465004040 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446465004041 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 446465004042 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 446465004043 active site 446465004044 catalytic site [active] 446465004045 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 446465004046 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 446465004047 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 446465004048 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 446465004049 active site 446465004050 catalytic site [active] 446465004051 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 446465004052 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 446465004053 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 446465004054 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 446465004055 active site 446465004056 dimer interface [polypeptide binding]; other site 446465004057 motif 1; other site 446465004058 motif 2; other site 446465004059 motif 3; other site 446465004060 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 446465004061 anticodon binding site; other site 446465004062 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 446465004063 nucleotide binding site/active site [active] 446465004064 HIT family signature motif; other site 446465004065 catalytic residue [active] 446465004066 Protease prsW family; Region: PrsW-protease; pfam13367 446465004067 hypothetical protein; Validated; Region: PRK00110 446465004068 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 446465004069 active site 446465004070 putative DNA-binding cleft [nucleotide binding]; other site 446465004071 dimer interface [polypeptide binding]; other site 446465004072 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 446465004073 RuvA N terminal domain; Region: RuvA_N; pfam01330 446465004074 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 446465004075 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 446465004076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465004077 Walker A motif; other site 446465004078 ATP binding site [chemical binding]; other site 446465004079 Walker B motif; other site 446465004080 arginine finger; other site 446465004081 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 446465004082 Preprotein translocase subunit; Region: YajC; pfam02699 446465004083 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 446465004084 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 446465004085 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 446465004086 Protein export membrane protein; Region: SecD_SecF; pfam02355 446465004087 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446465004088 active site 446465004089 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 446465004090 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446465004091 Zn2+ binding site [ion binding]; other site 446465004092 Mg2+ binding site [ion binding]; other site 446465004093 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446465004094 synthetase active site [active] 446465004095 NTP binding site [chemical binding]; other site 446465004096 metal binding site [ion binding]; metal-binding site 446465004097 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 446465004098 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 446465004099 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446465004100 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446465004101 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 446465004102 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 446465004103 dimer interface [polypeptide binding]; other site 446465004104 motif 1; other site 446465004105 active site 446465004106 motif 2; other site 446465004107 motif 3; other site 446465004108 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 446465004109 anticodon binding site; other site 446465004110 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446465004111 catalytic residues [active] 446465004112 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 446465004113 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446465004114 ATP binding site [chemical binding]; other site 446465004115 Mg++ binding site [ion binding]; other site 446465004116 motif III; other site 446465004117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465004118 nucleotide binding region [chemical binding]; other site 446465004119 ATP-binding site [chemical binding]; other site 446465004120 DbpA RNA binding domain; Region: DbpA; pfam03880 446465004121 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 446465004122 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 446465004123 dimer interface [polypeptide binding]; other site 446465004124 anticodon binding site; other site 446465004125 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 446465004126 homodimer interface [polypeptide binding]; other site 446465004127 motif 1; other site 446465004128 active site 446465004129 motif 2; other site 446465004130 GAD domain; Region: GAD; pfam02938 446465004131 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446465004132 active site 446465004133 motif 3; other site 446465004134 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 446465004135 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 446465004136 hypothetical protein; Provisional; Region: PRK07907 446465004137 active site 446465004138 metal binding site [ion binding]; metal-binding site 446465004139 dimer interface [polypeptide binding]; other site 446465004140 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 446465004141 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 446465004142 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 446465004143 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 446465004144 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 446465004145 D-pathway; other site 446465004146 Putative ubiquinol binding site [chemical binding]; other site 446465004147 Low-spin heme (heme b) binding site [chemical binding]; other site 446465004148 Putative water exit pathway; other site 446465004149 Binuclear center (heme o3/CuB) [ion binding]; other site 446465004150 K-pathway; other site 446465004151 Putative proton exit pathway; other site 446465004152 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 446465004153 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 446465004154 heme bH binding site [chemical binding]; other site 446465004155 intrachain domain interface; other site 446465004156 heme bL binding site [chemical binding]; other site 446465004157 interchain domain interface [polypeptide binding]; other site 446465004158 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 446465004159 Qo binding site; other site 446465004160 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 446465004161 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 446465004162 iron-sulfur cluster [ion binding]; other site 446465004163 [2Fe-2S] cluster binding site [ion binding]; other site 446465004164 Cytochrome c; Region: Cytochrom_C; pfam00034 446465004165 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 446465004166 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 446465004167 Subunit I/III interface [polypeptide binding]; other site 446465004168 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 446465004169 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446465004170 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446465004171 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446465004172 AsnC family; Region: AsnC_trans_reg; pfam01037 446465004173 hypothetical protein; Validated; Region: PRK07883 446465004174 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446465004175 active site 446465004176 catalytic site [active] 446465004177 substrate binding site [chemical binding]; other site 446465004178 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 446465004179 GIY-YIG motif/motif A; other site 446465004180 active site 446465004181 catalytic site [active] 446465004182 putative DNA binding site [nucleotide binding]; other site 446465004183 metal binding site [ion binding]; metal-binding site 446465004184 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446465004185 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 446465004186 acyl-activating enzyme (AAE) consensus motif; other site 446465004187 putative AMP binding site [chemical binding]; other site 446465004188 putative active site [active] 446465004189 putative CoA binding site [chemical binding]; other site 446465004190 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 446465004191 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446465004192 nucleotide binding site [chemical binding]; other site 446465004193 Esterase/lipase [General function prediction only]; Region: COG1647 446465004194 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446465004195 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446465004196 putative acyl-acceptor binding pocket; other site 446465004197 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 446465004198 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446465004199 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465004200 active site 446465004201 ATP binding site [chemical binding]; other site 446465004202 substrate binding site [chemical binding]; other site 446465004203 activation loop (A-loop); other site 446465004204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 446465004205 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446465004206 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446465004207 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446465004208 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446465004209 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446465004210 substrate binding pocket [chemical binding]; other site 446465004211 chain length determination region; other site 446465004212 substrate-Mg2+ binding site; other site 446465004213 catalytic residues [active] 446465004214 aspartate-rich region 1; other site 446465004215 active site lid residues [active] 446465004216 aspartate-rich region 2; other site 446465004217 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 446465004218 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 446465004219 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446465004220 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446465004221 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446465004222 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446465004223 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446465004224 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446465004225 DNA binding residues [nucleotide binding] 446465004226 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446465004227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465004228 Coenzyme A binding pocket [chemical binding]; other site 446465004229 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 446465004230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465004231 ATP binding site [chemical binding]; other site 446465004232 Mg2+ binding site [ion binding]; other site 446465004233 G-X-G motif; other site 446465004234 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 446465004235 anchoring element; other site 446465004236 dimer interface [polypeptide binding]; other site 446465004237 ATP binding site [chemical binding]; other site 446465004238 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 446465004239 active site 446465004240 metal binding site [ion binding]; metal-binding site 446465004241 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446465004242 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 446465004243 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 446465004244 substrate binding site [chemical binding]; other site 446465004245 glutamase interaction surface [polypeptide binding]; other site 446465004246 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 446465004247 active site 446465004248 phosphate binding residues; other site 446465004249 catalytic residues [active] 446465004250 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 446465004251 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 446465004252 CAP-like domain; other site 446465004253 active site 446465004254 primary dimer interface [polypeptide binding]; other site 446465004255 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446465004256 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446465004257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465004258 Coenzyme A binding pocket [chemical binding]; other site 446465004259 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 446465004260 CoA binding domain; Region: CoA_binding_2; pfam13380 446465004261 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 446465004262 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 446465004263 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 446465004264 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 446465004265 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 446465004266 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 446465004267 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446465004268 trimer interface [polypeptide binding]; other site 446465004269 active site 446465004270 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 446465004271 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 446465004272 TRAM domain; Region: TRAM; cl01282 446465004273 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 446465004274 aconitate hydratase; Validated; Region: PRK09277 446465004275 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446465004276 substrate binding site [chemical binding]; other site 446465004277 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446465004278 ligand binding site [chemical binding]; other site 446465004279 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 446465004280 substrate binding site [chemical binding]; other site 446465004281 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 446465004282 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 446465004283 TPP-binding site [chemical binding]; other site 446465004284 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446465004285 PYR/PP interface [polypeptide binding]; other site 446465004286 dimer interface [polypeptide binding]; other site 446465004287 TPP binding site [chemical binding]; other site 446465004288 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446465004289 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446465004290 active site 446465004291 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 446465004292 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 446465004293 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446465004294 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 446465004295 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446465004296 Walker A/P-loop; other site 446465004297 ATP binding site [chemical binding]; other site 446465004298 Q-loop/lid; other site 446465004299 ABC transporter signature motif; other site 446465004300 Walker B; other site 446465004301 D-loop; other site 446465004302 H-loop/switch region; other site 446465004303 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 446465004304 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 446465004305 putative dimer interface [polypeptide binding]; other site 446465004306 N-terminal domain interface [polypeptide binding]; other site 446465004307 putative substrate binding pocket (H-site) [chemical binding]; other site 446465004308 Predicted transcriptional regulator [Transcription]; Region: COG2345 446465004309 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465004310 putative DNA binding site [nucleotide binding]; other site 446465004311 putative Zn2+ binding site [ion binding]; other site 446465004312 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 446465004313 FeS assembly protein SufB; Region: sufB; TIGR01980 446465004314 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 446465004315 FeS assembly protein SufD; Region: sufD; TIGR01981 446465004316 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 446465004317 [2Fe-2S] cluster binding site [ion binding]; other site 446465004318 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 446465004319 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 446465004320 Walker A/P-loop; other site 446465004321 ATP binding site [chemical binding]; other site 446465004322 Q-loop/lid; other site 446465004323 ABC transporter signature motif; other site 446465004324 Walker B; other site 446465004325 D-loop; other site 446465004326 H-loop/switch region; other site 446465004327 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 446465004328 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 446465004329 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 446465004330 hexamer interface [polypeptide binding]; other site 446465004331 ligand binding site [chemical binding]; other site 446465004332 putative active site [active] 446465004333 NAD(P) binding site [chemical binding]; other site 446465004334 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446465004335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465004336 Walker A/P-loop; other site 446465004337 ATP binding site [chemical binding]; other site 446465004338 Q-loop/lid; other site 446465004339 ABC transporter signature motif; other site 446465004340 Walker B; other site 446465004341 D-loop; other site 446465004342 H-loop/switch region; other site 446465004343 ABC transporter; Region: ABC_tran_2; pfam12848 446465004344 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446465004345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465004346 non-specific DNA binding site [nucleotide binding]; other site 446465004347 salt bridge; other site 446465004348 sequence-specific DNA binding site [nucleotide binding]; other site 446465004349 elongation factor P; Validated; Region: PRK00529 446465004350 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 446465004351 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 446465004352 RNA binding site [nucleotide binding]; other site 446465004353 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 446465004354 RNA binding site [nucleotide binding]; other site 446465004355 transcription antitermination factor NusB; Region: nusB; TIGR01951 446465004356 putative RNA binding site [nucleotide binding]; other site 446465004357 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 446465004358 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446465004359 active site 446465004360 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 446465004361 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446465004362 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 446465004363 dihydroorotase; Validated; Region: pyrC; PRK09357 446465004364 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446465004365 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 446465004366 active site 446465004367 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 446465004368 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 446465004369 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 446465004370 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 446465004371 catalytic site [active] 446465004372 subunit interface [polypeptide binding]; other site 446465004373 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 446465004374 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446465004375 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446465004376 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 446465004377 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446465004378 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446465004379 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 446465004380 IMP binding site; other site 446465004381 dimer interface [polypeptide binding]; other site 446465004382 interdomain contacts; other site 446465004383 partial ornithine binding site; other site 446465004384 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 446465004385 active site 446465004386 dimer interface [polypeptide binding]; other site 446465004387 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 446465004388 Guanylate kinase; Region: Guanylate_kin; pfam00625 446465004389 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 446465004390 catalytic site [active] 446465004391 G-X2-G-X-G-K; other site 446465004392 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 446465004393 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 446465004394 Flavoprotein; Region: Flavoprotein; pfam02441 446465004395 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 446465004396 S-adenosylmethionine synthetase; Validated; Region: PRK05250 446465004397 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 446465004398 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 446465004399 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 446465004400 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 446465004401 anthranilate synthase component I; Provisional; Region: PRK13571 446465004402 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 446465004403 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446465004404 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 446465004405 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 446465004406 active site 446465004407 ribulose/triose binding site [chemical binding]; other site 446465004408 substrate (anthranilate) binding pocket [chemical binding]; other site 446465004409 product (indole) binding pocket [chemical binding]; other site 446465004410 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 446465004411 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 446465004412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465004413 catalytic residue [active] 446465004414 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 446465004415 substrate binding site [chemical binding]; other site 446465004416 active site 446465004417 catalytic residues [active] 446465004418 heterodimer interface [polypeptide binding]; other site 446465004419 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 446465004420 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 446465004421 pyruvate kinase; Provisional; Region: PRK06247 446465004422 domain interfaces; other site 446465004423 active site 446465004424 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 446465004425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465004426 active site 446465004427 phosphorylation site [posttranslational modification] 446465004428 intermolecular recognition site; other site 446465004429 dimerization interface [polypeptide binding]; other site 446465004430 ANTAR domain; Region: ANTAR; pfam03861 446465004431 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 446465004432 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 446465004433 ligand binding site [chemical binding]; other site 446465004434 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446465004435 CoenzymeA binding site [chemical binding]; other site 446465004436 subunit interaction site [polypeptide binding]; other site 446465004437 PHB binding site; other site 446465004438 DNA polymerase I; Provisional; Region: PRK05755 446465004439 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 446465004440 active site 446465004441 metal binding site 1 [ion binding]; metal-binding site 446465004442 putative 5' ssDNA interaction site; other site 446465004443 metal binding site 3; metal-binding site 446465004444 metal binding site 2 [ion binding]; metal-binding site 446465004445 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 446465004446 putative DNA binding site [nucleotide binding]; other site 446465004447 putative metal binding site [ion binding]; other site 446465004448 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 446465004449 active site 446465004450 DNA binding site [nucleotide binding] 446465004451 catalytic site [active] 446465004452 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 446465004453 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 446465004454 RNA binding site [nucleotide binding]; other site 446465004455 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 446465004456 RNA binding site [nucleotide binding]; other site 446465004457 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446465004458 RNA binding site [nucleotide binding]; other site 446465004459 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 446465004460 RNA binding site [nucleotide binding]; other site 446465004461 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 446465004462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465004463 active site 446465004464 motif I; other site 446465004465 motif II; other site 446465004466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465004467 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 446465004468 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 446465004469 Tetramer interface [polypeptide binding]; other site 446465004470 active site 446465004471 FMN-binding site [chemical binding]; other site 446465004472 shikimate kinase; Reviewed; Region: aroK; PRK00131 446465004473 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 446465004474 ADP binding site [chemical binding]; other site 446465004475 magnesium binding site [ion binding]; other site 446465004476 putative shikimate binding site; other site 446465004477 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 446465004478 active site 446465004479 dimer interface [polypeptide binding]; other site 446465004480 metal binding site [ion binding]; metal-binding site 446465004481 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 446465004482 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 446465004483 active site 446465004484 catalytic residue [active] 446465004485 dimer interface [polypeptide binding]; other site 446465004486 Predicted membrane protein [Function unknown]; Region: COG2860 446465004487 UPF0126 domain; Region: UPF0126; pfam03458 446465004488 UPF0126 domain; Region: UPF0126; pfam03458 446465004489 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 446465004490 CoA-binding site [chemical binding]; other site 446465004491 ATP-binding [chemical binding]; other site 446465004492 excinuclease ABC subunit B; Provisional; Region: PRK05298 446465004493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465004494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465004495 nucleotide binding region [chemical binding]; other site 446465004496 ATP-binding site [chemical binding]; other site 446465004497 Ultra-violet resistance protein B; Region: UvrB; pfam12344 446465004498 UvrB/uvrC motif; Region: UVR; pfam02151 446465004499 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446465004500 nudix motif; other site 446465004501 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 446465004502 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 446465004503 active site 446465004504 DNA binding site [nucleotide binding] 446465004505 catalytic site [active] 446465004506 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 446465004507 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 446465004508 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446465004509 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446465004510 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 446465004511 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 446465004512 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 446465004513 GIY-YIG motif/motif A; other site 446465004514 active site 446465004515 catalytic site [active] 446465004516 putative DNA binding site [nucleotide binding]; other site 446465004517 metal binding site [ion binding]; metal-binding site 446465004518 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 446465004519 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 446465004520 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 446465004521 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 446465004522 putative substrate binding pocket [chemical binding]; other site 446465004523 dimer interface [polypeptide binding]; other site 446465004524 phosphate binding site [ion binding]; other site 446465004525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 446465004526 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 446465004527 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 446465004528 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 446465004529 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 446465004530 Phosphoglycerate kinase; Region: PGK; pfam00162 446465004531 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 446465004532 substrate binding site [chemical binding]; other site 446465004533 hinge regions; other site 446465004534 ADP binding site [chemical binding]; other site 446465004535 catalytic site [active] 446465004536 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 446465004537 triosephosphate isomerase; Provisional; Region: PRK14567 446465004538 substrate binding site [chemical binding]; other site 446465004539 dimer interface [polypeptide binding]; other site 446465004540 catalytic triad [active] 446465004541 Preprotein translocase SecG subunit; Region: SecG; cl09123 446465004542 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 446465004543 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 446465004544 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 446465004545 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 446465004546 putative active site [active] 446465004547 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 446465004548 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 446465004549 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 446465004550 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 446465004551 putative active site [active] 446465004552 transaldolase; Provisional; Region: PRK03903 446465004553 catalytic residue [active] 446465004554 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 446465004555 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 446465004556 TPP-binding site [chemical binding]; other site 446465004557 dimer interface [polypeptide binding]; other site 446465004558 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446465004559 PYR/PP interface [polypeptide binding]; other site 446465004560 dimer interface [polypeptide binding]; other site 446465004561 TPP binding site [chemical binding]; other site 446465004562 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446465004563 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 446465004564 UbiA prenyltransferase family; Region: UbiA; pfam01040 446465004565 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 446465004566 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446465004567 active site 446465004568 DNA binding site [nucleotide binding] 446465004569 Int/Topo IB signature motif; other site 446465004570 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446465004571 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446465004572 P-loop; other site 446465004573 Magnesium ion binding site [ion binding]; other site 446465004574 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 446465004575 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446465004576 Magnesium ion binding site [ion binding]; other site 446465004577 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 446465004578 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446465004579 RNA binding surface [nucleotide binding]; other site 446465004580 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 446465004581 active site 446465004582 prephenate dehydrogenase; Validated; Region: PRK06545 446465004583 prephenate dehydrogenase; Validated; Region: PRK08507 446465004584 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446465004585 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 446465004586 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 446465004587 CMP-binding site; other site 446465004588 The sites determining sugar specificity; other site 446465004589 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 446465004590 G1 box; other site 446465004591 GTP/Mg2+ binding site [chemical binding]; other site 446465004592 Switch I region; other site 446465004593 G2 box; other site 446465004594 Switch II region; other site 446465004595 G3 box; other site 446465004596 G4 box; other site 446465004597 G5 box; other site 446465004598 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 446465004599 G1 box; other site 446465004600 GTP/Mg2+ binding site [chemical binding]; other site 446465004601 Switch I region; other site 446465004602 G2 box; other site 446465004603 G3 box; other site 446465004604 Switch II region; other site 446465004605 G4 box; other site 446465004606 G5 box; other site 446465004607 TM2 domain; Region: TM2; pfam05154 446465004608 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446465004609 nudix motif; other site 446465004610 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465004611 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465004612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465004613 dimer interface [polypeptide binding]; other site 446465004614 conserved gate region; other site 446465004615 putative PBP binding loops; other site 446465004616 ABC-ATPase subunit interface; other site 446465004617 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465004618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465004619 dimer interface [polypeptide binding]; other site 446465004620 conserved gate region; other site 446465004621 putative PBP binding loops; other site 446465004622 ABC-ATPase subunit interface; other site 446465004623 short chain dehydrogenase; Provisional; Region: PRK06701 446465004624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465004625 NAD(P) binding site [chemical binding]; other site 446465004626 active site 446465004627 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 446465004628 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 446465004629 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 446465004630 active site 446465004631 substrate binding site [chemical binding]; other site 446465004632 cosubstrate binding site; other site 446465004633 catalytic site [active] 446465004634 MMPL family; Region: MMPL; pfam03176 446465004635 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 446465004636 MarR family; Region: MarR; pfam01047 446465004637 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 446465004638 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446465004639 inhibitor-cofactor binding pocket; inhibition site 446465004640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465004641 catalytic residue [active] 446465004642 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 446465004643 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 446465004644 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 446465004645 active site 446465004646 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446465004647 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 446465004648 NAD(P) binding site [chemical binding]; other site 446465004649 catalytic residues [active] 446465004650 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 446465004651 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 446465004652 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 446465004653 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446465004654 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446465004655 phosphopeptide binding site; other site 446465004656 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446465004657 DNA binding residues [nucleotide binding] 446465004658 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446465004659 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 446465004660 DNA binding residues [nucleotide binding] 446465004661 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446465004662 putative dimer interface [polypeptide binding]; other site 446465004663 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446465004664 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 446465004665 P-loop; other site 446465004666 Magnesium ion binding site [ion binding]; other site 446465004667 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446465004668 Magnesium ion binding site [ion binding]; other site 446465004669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446465004670 TIGR03085 family protein; Region: TIGR03085 446465004671 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446465004672 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 446465004673 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465004674 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465004675 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465004676 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 446465004677 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 446465004678 PAC2 family; Region: PAC2; pfam09754 446465004679 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446465004680 hypothetical protein; Provisional; Region: PRK10621 446465004681 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 446465004682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465004683 motif II; other site 446465004684 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 446465004685 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446465004686 Walker A/P-loop; other site 446465004687 ATP binding site [chemical binding]; other site 446465004688 Q-loop/lid; other site 446465004689 ABC transporter signature motif; other site 446465004690 Walker B; other site 446465004691 D-loop; other site 446465004692 H-loop/switch region; other site 446465004693 glycogen branching enzyme; Provisional; Region: PRK14705 446465004694 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 446465004695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465004696 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 446465004697 putative substrate translocation pore; other site 446465004698 CAAX protease self-immunity; Region: Abi; pfam02517 446465004699 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 446465004700 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 446465004701 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446465004702 active site 446465004703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465004704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465004705 MMPL family; Region: MMPL; pfam03176 446465004706 MMPL family; Region: MMPL; pfam03176 446465004707 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 446465004708 Predicted membrane protein [Function unknown]; Region: COG1511 446465004709 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 446465004710 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 446465004711 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 446465004712 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 446465004713 active site 446465004714 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 446465004715 generic binding surface II; other site 446465004716 generic binding surface I; other site 446465004717 DNA Polymerase Y-family; Region: PolY_like; cd03468 446465004718 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 446465004719 DNA binding site [nucleotide binding] 446465004720 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465004721 active site 446465004722 YrhK-like protein; Region: YrhK; pfam14145 446465004723 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446465004724 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 446465004725 inhibitor binding site; inhibition site 446465004726 catalytic Zn binding site [ion binding]; other site 446465004727 structural Zn binding site [ion binding]; other site 446465004728 NADP binding site [chemical binding]; other site 446465004729 tetramer interface [polypeptide binding]; other site 446465004730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465004731 S-adenosylmethionine binding site [chemical binding]; other site 446465004732 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446465004733 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446465004734 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446465004735 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446465004736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465004737 Walker A/P-loop; other site 446465004738 ATP binding site [chemical binding]; other site 446465004739 Q-loop/lid; other site 446465004740 ABC transporter signature motif; other site 446465004741 Walker B; other site 446465004742 D-loop; other site 446465004743 H-loop/switch region; other site 446465004744 RNB domain; Region: RNB; pfam00773 446465004745 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 446465004746 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446465004747 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 446465004748 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 446465004749 ligand binding site; other site 446465004750 oligomer interface; other site 446465004751 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 446465004752 sulfate 1 binding site; other site 446465004753 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446465004754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465004755 motif II; other site 446465004756 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465004757 catalytic core [active] 446465004758 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 446465004759 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 446465004760 NAD(P) binding site [chemical binding]; other site 446465004761 homotetramer interface [polypeptide binding]; other site 446465004762 homodimer interface [polypeptide binding]; other site 446465004763 active site 446465004764 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 446465004765 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 446465004766 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 446465004767 putative active site [active] 446465004768 catalytic site [active] 446465004769 putative metal binding site [ion binding]; other site 446465004770 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 446465004771 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 446465004772 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 446465004773 Ligand binding site; other site 446465004774 Putative Catalytic site; other site 446465004775 DXD motif; other site 446465004776 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 446465004777 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 446465004778 putative active site [active] 446465004779 catalytic triad [active] 446465004780 putative dimer interface [polypeptide binding]; other site 446465004781 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446465004782 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446465004783 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465004784 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465004785 ATP binding site [chemical binding]; other site 446465004786 putative Mg++ binding site [ion binding]; other site 446465004787 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 446465004788 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465004789 nucleotide binding region [chemical binding]; other site 446465004790 ATP-binding site [chemical binding]; other site 446465004791 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 446465004792 diacylglycerol kinase; Reviewed; Region: PRK11914 446465004793 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 446465004794 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 446465004795 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 446465004796 Predicted transcriptional regulator [Transcription]; Region: COG2378 446465004797 WYL domain; Region: WYL; pfam13280 446465004798 WYL domain; Region: WYL; pfam13280 446465004799 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 446465004800 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446465004801 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 446465004802 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 446465004803 HisG, C-terminal domain; Region: HisG_C; pfam08029 446465004804 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 446465004805 homodimer interface [polypeptide binding]; other site 446465004806 putative metal binding site [ion binding]; other site 446465004807 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 446465004808 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 446465004809 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 446465004810 substrate binding site [chemical binding]; other site 446465004811 hexamer interface [polypeptide binding]; other site 446465004812 metal binding site [ion binding]; metal-binding site 446465004813 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 446465004814 16S rRNA methyltransferase B; Provisional; Region: PRK14902 446465004815 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 446465004816 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 446465004817 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 446465004818 putative active site [active] 446465004819 substrate binding site [chemical binding]; other site 446465004820 putative cosubstrate binding site; other site 446465004821 catalytic site [active] 446465004822 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 446465004823 substrate binding site [chemical binding]; other site 446465004824 primosome assembly protein PriA; Provisional; Region: PRK14873 446465004825 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446465004826 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446465004827 Pup-ligase protein; Region: Pup_ligase; cl15463 446465004828 Pup-like protein; Region: Pup; pfam05639 446465004829 Pup-ligase protein; Region: Pup_ligase; pfam03136 446465004830 proteasome ATPase; Region: pup_AAA; TIGR03689 446465004831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465004832 Walker A motif; other site 446465004833 ATP binding site [chemical binding]; other site 446465004834 Walker B motif; other site 446465004835 arginine finger; other site 446465004836 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 446465004837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465004838 S-adenosylmethionine binding site [chemical binding]; other site 446465004839 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 446465004840 active site 446465004841 Peptidase family M50; Region: Peptidase_M50; pfam02163 446465004842 putative substrate binding region [chemical binding]; other site 446465004843 PAC2 family; Region: PAC2; pfam09754 446465004844 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465004845 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 446465004846 active site 446465004847 HIGH motif; other site 446465004848 nucleotide binding site [chemical binding]; other site 446465004849 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465004850 active site 446465004851 KMSKS motif; other site 446465004852 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446465004853 tRNA binding surface [nucleotide binding]; other site 446465004854 anticodon binding site; other site 446465004855 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 446465004856 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446465004857 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446465004858 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 446465004859 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 446465004860 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 446465004861 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 446465004862 shikimate binding site; other site 446465004863 NAD(P) binding site [chemical binding]; other site 446465004864 YceG-like family; Region: YceG; pfam02618 446465004865 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 446465004866 dimerization interface [polypeptide binding]; other site 446465004867 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 446465004868 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 446465004869 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 446465004870 motif 1; other site 446465004871 active site 446465004872 motif 2; other site 446465004873 motif 3; other site 446465004874 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 446465004875 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 446465004876 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 446465004877 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446465004878 RNA binding surface [nucleotide binding]; other site 446465004879 recombination factor protein RarA; Reviewed; Region: PRK13342 446465004880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465004881 Walker A motif; other site 446465004882 ATP binding site [chemical binding]; other site 446465004883 Walker B motif; other site 446465004884 arginine finger; other site 446465004885 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 446465004886 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 446465004887 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 446465004888 active site 446465004889 catalytic residues [active] 446465004890 FMN binding site [chemical binding]; other site 446465004891 quinone interaction residues [chemical binding]; other site 446465004892 substrate binding site [chemical binding]; other site 446465004893 multifunctional aminopeptidase A; Provisional; Region: PRK00913 446465004894 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 446465004895 interface (dimer of trimers) [polypeptide binding]; other site 446465004896 Substrate-binding/catalytic site; other site 446465004897 Zn-binding sites [ion binding]; other site 446465004898 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 446465004899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446465004900 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446465004901 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446465004902 E3 interaction surface; other site 446465004903 lipoyl attachment site [posttranslational modification]; other site 446465004904 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446465004905 E3 interaction surface; other site 446465004906 lipoyl attachment site [posttranslational modification]; other site 446465004907 e3 binding domain; Region: E3_binding; pfam02817 446465004908 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 446465004909 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446465004910 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 446465004911 lipoyl synthase; Provisional; Region: PRK05481 446465004912 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446465004913 FeS/SAM binding site; other site 446465004914 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 446465004915 Domain of unknown function (DUF4203); Region: DUF4203; pfam13886 446465004916 RDD family; Region: RDD; pfam06271 446465004917 glutamine synthetase, type I; Region: GlnA; TIGR00653 446465004918 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446465004919 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446465004920 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 446465004921 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446465004922 catalytic loop [active] 446465004923 iron binding site [ion binding]; other site 446465004924 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 446465004925 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446465004926 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446465004927 Walker A/P-loop; other site 446465004928 ATP binding site [chemical binding]; other site 446465004929 Q-loop/lid; other site 446465004930 ABC transporter signature motif; other site 446465004931 Walker B; other site 446465004932 D-loop; other site 446465004933 H-loop/switch region; other site 446465004934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465004935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465004936 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 446465004937 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 446465004938 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446465004939 metal binding triad; other site 446465004940 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446465004941 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446465004942 metal binding triad; other site 446465004943 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446465004944 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 446465004945 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446465004946 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446465004947 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 446465004948 oligomerization interface [polypeptide binding]; other site 446465004949 active site 446465004950 metal binding site [ion binding]; metal-binding site 446465004951 methionine aminopeptidase; Provisional; Region: PRK12318 446465004952 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446465004953 active site 446465004954 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465004955 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446465004956 nucleotide binding site [chemical binding]; other site 446465004957 Protein of unknown function (DUF328); Region: DUF328; cl01143 446465004958 Uncharacterized conserved protein [Function unknown]; Region: COG0327 446465004959 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 446465004960 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 446465004961 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 446465004962 trimerization site [polypeptide binding]; other site 446465004963 active site 446465004964 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446465004965 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 446465004966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465004967 catalytic residue [active] 446465004968 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 446465004969 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 446465004970 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 446465004971 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 446465004972 dimer interface [polypeptide binding]; other site 446465004973 TPP-binding site [chemical binding]; other site 446465004974 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 446465004975 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446465004976 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 446465004977 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 446465004978 dimer interface [polypeptide binding]; other site 446465004979 active site 446465004980 CoA binding pocket [chemical binding]; other site 446465004981 acyl carrier protein; Provisional; Region: acpP; PRK00982 446465004982 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 446465004983 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 446465004984 dimer interface [polypeptide binding]; other site 446465004985 active site 446465004986 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 446465004987 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446465004988 active site 446465004989 catalytic residues [active] 446465004990 metal binding site [ion binding]; metal-binding site 446465004991 OsmC-like protein; Region: OsmC; pfam02566 446465004992 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465004993 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465004994 DNA binding site [nucleotide binding] 446465004995 domain linker motif; other site 446465004996 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465004997 dimerization interface [polypeptide binding]; other site 446465004998 ligand binding site [chemical binding]; other site 446465004999 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 446465005000 Helix-turn-helix domain; Region: HTH_17; cl17695 446465005001 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 446465005002 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 446465005003 DNA primase; Validated; Region: dnaG; PRK05667 446465005004 CHC2 zinc finger; Region: zf-CHC2; pfam01807 446465005005 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 446465005006 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 446465005007 active site 446465005008 metal binding site [ion binding]; metal-binding site 446465005009 interdomain interaction site; other site 446465005010 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 446465005011 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 446465005012 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 446465005013 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446465005014 Zn2+ binding site [ion binding]; other site 446465005015 Mg2+ binding site [ion binding]; other site 446465005016 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 446465005017 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 446465005018 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 446465005019 FMN binding site [chemical binding]; other site 446465005020 active site 446465005021 catalytic residues [active] 446465005022 substrate binding site [chemical binding]; other site 446465005023 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446465005024 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446465005025 MarR family; Region: MarR_2; pfam12802 446465005026 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465005027 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465005028 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465005029 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465005030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465005031 dimer interface [polypeptide binding]; other site 446465005032 conserved gate region; other site 446465005033 putative PBP binding loops; other site 446465005034 ABC-ATPase subunit interface; other site 446465005035 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465005036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465005037 dimer interface [polypeptide binding]; other site 446465005038 conserved gate region; other site 446465005039 putative PBP binding loops; other site 446465005040 ABC-ATPase subunit interface; other site 446465005041 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446465005042 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446465005043 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446465005044 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 446465005045 glycyl-tRNA synthetase; Provisional; Region: PRK04173 446465005046 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446465005047 motif 1; other site 446465005048 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 446465005049 motif 1; other site 446465005050 dimer interface [polypeptide binding]; other site 446465005051 active site 446465005052 motif 2; other site 446465005053 motif 3; other site 446465005054 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 446465005055 anticodon binding site; other site 446465005056 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446465005057 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 446465005058 intersubunit interface [polypeptide binding]; other site 446465005059 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 446465005060 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 446465005061 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 446465005062 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446465005063 ABC-ATPase subunit interface; other site 446465005064 dimer interface [polypeptide binding]; other site 446465005065 putative PBP binding regions; other site 446465005066 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446465005067 metal binding site 2 [ion binding]; metal-binding site 446465005068 putative DNA binding helix; other site 446465005069 metal binding site 1 [ion binding]; metal-binding site 446465005070 dimer interface [polypeptide binding]; other site 446465005071 structural Zn2+ binding site [ion binding]; other site 446465005072 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446465005073 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 446465005074 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 446465005075 catalytic residue [active] 446465005076 putative FPP diphosphate binding site; other site 446465005077 putative FPP binding hydrophobic cleft; other site 446465005078 dimer interface [polypeptide binding]; other site 446465005079 putative IPP diphosphate binding site; other site 446465005080 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 446465005081 Recombination protein O N terminal; Region: RecO_N; pfam11967 446465005082 Recombination protein O C terminal; Region: RecO_C; pfam02565 446465005083 EcsC protein family; Region: EcsC; pfam12787 446465005084 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 446465005085 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 446465005086 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 446465005087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465005088 S-adenosylmethionine binding site [chemical binding]; other site 446465005089 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 446465005090 Peptidase family M28; Region: Peptidase_M28; pfam04389 446465005091 metal binding site [ion binding]; metal-binding site 446465005092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446465005093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446465005094 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446465005095 putative dimerization interface [polypeptide binding]; other site 446465005096 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 446465005097 2-isopropylmalate synthase; Validated; Region: PRK03739 446465005098 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 446465005099 active site 446465005100 catalytic residues [active] 446465005101 metal binding site [ion binding]; metal-binding site 446465005102 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 446465005103 GTPase Era; Reviewed; Region: era; PRK00089 446465005104 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 446465005105 G1 box; other site 446465005106 GTP/Mg2+ binding site [chemical binding]; other site 446465005107 Switch I region; other site 446465005108 G2 box; other site 446465005109 Switch II region; other site 446465005110 G3 box; other site 446465005111 G4 box; other site 446465005112 G5 box; other site 446465005113 KH domain; Region: KH_2; pfam07650 446465005114 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 446465005115 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446465005116 Transporter associated domain; Region: CorC_HlyC; cl08393 446465005117 metal-binding heat shock protein; Provisional; Region: PRK00016 446465005118 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 446465005119 PhoH-like protein; Region: PhoH; pfam02562 446465005120 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 446465005121 nucleotide binding site/active site [active] 446465005122 HIT family signature motif; other site 446465005123 catalytic residue [active] 446465005124 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446465005125 Predicted flavoprotein [General function prediction only]; Region: COG0431 446465005126 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 446465005127 RNA methyltransferase, RsmE family; Region: TIGR00046 446465005128 chaperone protein DnaJ; Provisional; Region: PRK14278 446465005129 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446465005130 HSP70 interaction site [polypeptide binding]; other site 446465005131 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 446465005132 Zn binding sites [ion binding]; other site 446465005133 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 446465005134 dimer interface [polypeptide binding]; other site 446465005135 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 446465005136 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 446465005137 Tic20-like protein; Region: Tic20; pfam09685 446465005138 coproporphyrinogen III oxidase; Validated; Region: PRK05628 446465005139 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446465005140 FeS/SAM binding site; other site 446465005141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 446465005142 MOSC domain; Region: MOSC; pfam03473 446465005143 GTP-binding protein LepA; Provisional; Region: PRK05433 446465005144 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 446465005145 G1 box; other site 446465005146 putative GEF interaction site [polypeptide binding]; other site 446465005147 GTP/Mg2+ binding site [chemical binding]; other site 446465005148 Switch I region; other site 446465005149 G2 box; other site 446465005150 G3 box; other site 446465005151 Switch II region; other site 446465005152 G4 box; other site 446465005153 G5 box; other site 446465005154 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 446465005155 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 446465005156 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 446465005157 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 446465005158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 446465005159 Uncharacterized conserved protein [Function unknown]; Region: COG2308 446465005160 PemK-like protein; Region: PemK; pfam02452 446465005161 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 446465005162 hypothetical protein; Reviewed; Region: PRK07914 446465005163 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 446465005164 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 446465005165 Competence protein; Region: Competence; pfam03772 446465005166 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 446465005167 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446465005168 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 446465005169 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 446465005170 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 446465005171 putative active site [active] 446465005172 redox center [active] 446465005173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465005174 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446465005175 NAD(P) binding site [chemical binding]; other site 446465005176 active site 446465005177 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446465005178 peptide synthase; Provisional; Region: PRK09274 446465005179 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446465005180 acyl-activating enzyme (AAE) consensus motif; other site 446465005181 AMP binding site [chemical binding]; other site 446465005182 active site 446465005183 CoA binding site [chemical binding]; other site 446465005184 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 446465005185 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446465005186 active site 446465005187 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 446465005188 AP (apurinic/apyrimidinic) site pocket; other site 446465005189 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465005190 DNA interaction; other site 446465005191 Metal-binding active site; metal-binding site 446465005192 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 446465005193 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 446465005194 Sterol carrier protein domain; Region: SCP2_2; pfam13530 446465005195 thymidine kinase; Provisional; Region: PRK04296 446465005196 OpgC protein; Region: OpgC_C; cl17858 446465005197 Proline dehydrogenase; Region: Pro_dh; cl03282 446465005198 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446465005199 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446465005200 NAD(P) binding site [chemical binding]; other site 446465005201 catalytic residues [active] 446465005202 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446465005203 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 446465005204 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 446465005205 active site 446465005206 substrate binding site; other site 446465005207 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446465005208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465005209 Walker A/P-loop; other site 446465005210 ATP binding site [chemical binding]; other site 446465005211 Q-loop/lid; other site 446465005212 ABC transporter signature motif; other site 446465005213 Walker B; other site 446465005214 D-loop; other site 446465005215 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446465005216 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 446465005217 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 446465005218 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 446465005219 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 446465005220 active site 446465005221 HIGH motif; other site 446465005222 KMSKS motif; other site 446465005223 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 446465005224 tRNA binding surface [nucleotide binding]; other site 446465005225 anticodon binding site; other site 446465005226 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 446465005227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465005228 putative substrate translocation pore; other site 446465005229 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 446465005230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465005231 transketolase; Reviewed; Region: PRK05899 446465005232 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 446465005233 TPP-binding site [chemical binding]; other site 446465005234 dimer interface [polypeptide binding]; other site 446465005235 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446465005236 PYR/PP interface [polypeptide binding]; other site 446465005237 dimer interface [polypeptide binding]; other site 446465005238 TPP binding site [chemical binding]; other site 446465005239 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446465005240 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 446465005241 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446465005242 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446465005243 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446465005244 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 446465005245 homodimer interface [polypeptide binding]; other site 446465005246 substrate-cofactor binding pocket; other site 446465005247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465005248 catalytic residue [active] 446465005249 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446465005250 FAD binding pocket [chemical binding]; other site 446465005251 FAD binding motif [chemical binding]; other site 446465005252 phosphate binding motif [ion binding]; other site 446465005253 NAD binding pocket [chemical binding]; other site 446465005254 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 446465005255 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446465005256 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 446465005257 POT family; Region: PTR2; cl17359 446465005258 POT family; Region: PTR2; cl17359 446465005259 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 446465005260 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465005261 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 446465005262 active site 446465005263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465005264 non-specific DNA binding site [nucleotide binding]; other site 446465005265 salt bridge; other site 446465005266 sequence-specific DNA binding site [nucleotide binding]; other site 446465005267 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 446465005268 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 446465005269 putative active site [active] 446465005270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465005271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465005272 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465005273 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465005274 Walker A/P-loop; other site 446465005275 ATP binding site [chemical binding]; other site 446465005276 Q-loop/lid; other site 446465005277 ABC transporter signature motif; other site 446465005278 Walker B; other site 446465005279 D-loop; other site 446465005280 H-loop/switch region; other site 446465005281 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465005282 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465005283 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465005284 Walker A/P-loop; other site 446465005285 ATP binding site [chemical binding]; other site 446465005286 Q-loop/lid; other site 446465005287 ABC transporter signature motif; other site 446465005288 Walker B; other site 446465005289 D-loop; other site 446465005290 H-loop/switch region; other site 446465005291 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465005292 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465005293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465005294 dimer interface [polypeptide binding]; other site 446465005295 conserved gate region; other site 446465005296 putative PBP binding loops; other site 446465005297 ABC-ATPase subunit interface; other site 446465005298 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465005299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465005300 dimer interface [polypeptide binding]; other site 446465005301 conserved gate region; other site 446465005302 putative PBP binding loops; other site 446465005303 ABC-ATPase subunit interface; other site 446465005304 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446465005305 substrate binding site [chemical binding]; other site 446465005306 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465005307 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 446465005308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 446465005309 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446465005310 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 446465005311 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465005312 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465005313 DNA binding site [nucleotide binding] 446465005314 domain linker motif; other site 446465005315 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465005316 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465005317 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465005318 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446465005319 conserved cys residue [active] 446465005320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 446465005321 hypothetical protein; Provisional; Region: PRK13663 446465005322 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 446465005323 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 446465005324 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 446465005325 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465005326 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465005327 DNA binding site [nucleotide binding] 446465005328 domain linker motif; other site 446465005329 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 446465005330 putative dimerization interface [polypeptide binding]; other site 446465005331 putative ligand binding site [chemical binding]; other site 446465005332 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465005333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465005334 dimer interface [polypeptide binding]; other site 446465005335 conserved gate region; other site 446465005336 ABC-ATPase subunit interface; other site 446465005337 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465005338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465005339 dimer interface [polypeptide binding]; other site 446465005340 conserved gate region; other site 446465005341 putative PBP binding loops; other site 446465005342 ABC-ATPase subunit interface; other site 446465005343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465005344 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 446465005345 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 446465005346 substrate binding [chemical binding]; other site 446465005347 active site 446465005348 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 446465005349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465005350 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446465005351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446465005352 Coenzyme A binding pocket [chemical binding]; other site 446465005353 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446465005354 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446465005355 TM2 domain; Region: TM2; pfam05154 446465005356 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446465005357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465005358 putative substrate translocation pore; other site 446465005359 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 446465005360 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 446465005361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465005362 ATP binding site [chemical binding]; other site 446465005363 putative Mg++ binding site [ion binding]; other site 446465005364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465005365 nucleotide binding region [chemical binding]; other site 446465005366 ATP-binding site [chemical binding]; other site 446465005367 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 446465005368 HRDC domain; Region: HRDC; pfam00570 446465005369 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 446465005370 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446465005371 putative active site [active] 446465005372 putative metal binding site [ion binding]; other site 446465005373 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 446465005374 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446465005375 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465005376 Walker A/P-loop; other site 446465005377 ATP binding site [chemical binding]; other site 446465005378 Q-loop/lid; other site 446465005379 ABC transporter signature motif; other site 446465005380 Walker B; other site 446465005381 D-loop; other site 446465005382 H-loop/switch region; other site 446465005383 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465005384 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465005385 Walker A/P-loop; other site 446465005386 ATP binding site [chemical binding]; other site 446465005387 Q-loop/lid; other site 446465005388 ABC transporter signature motif; other site 446465005389 Walker B; other site 446465005390 D-loop; other site 446465005391 H-loop/switch region; other site 446465005392 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465005393 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465005394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465005395 dimer interface [polypeptide binding]; other site 446465005396 conserved gate region; other site 446465005397 ABC-ATPase subunit interface; other site 446465005398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446465005399 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465005400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465005401 putative PBP binding loops; other site 446465005402 dimer interface [polypeptide binding]; other site 446465005403 ABC-ATPase subunit interface; other site 446465005404 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446465005405 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446465005406 DoxX-like family; Region: DoxX_2; pfam13564 446465005407 NYN domain; Region: NYN; pfam01936 446465005408 Uncharacterized conserved protein [Function unknown]; Region: COG1432 446465005409 putative metal binding site [ion binding]; other site 446465005410 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 446465005411 Cupin domain; Region: Cupin_2; pfam07883 446465005412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446465005413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446465005414 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 446465005415 putative dimerization interface [polypeptide binding]; other site 446465005416 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 446465005417 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446465005418 DNA binding residues [nucleotide binding] 446465005419 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 446465005420 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 446465005421 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446465005422 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 446465005423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465005424 putative PBP binding loops; other site 446465005425 ABC-ATPase subunit interface; other site 446465005426 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446465005427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465005428 Walker A/P-loop; other site 446465005429 ATP binding site [chemical binding]; other site 446465005430 Q-loop/lid; other site 446465005431 ABC transporter signature motif; other site 446465005432 Walker B; other site 446465005433 D-loop; other site 446465005434 H-loop/switch region; other site 446465005435 TOBE domain; Region: TOBE_2; pfam08402 446465005436 Cation efflux family; Region: Cation_efflux; pfam01545 446465005437 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446465005438 minor groove reading motif; other site 446465005439 helix-hairpin-helix signature motif; other site 446465005440 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465005441 catalytic core [active] 446465005442 Oligomerisation domain; Region: Oligomerisation; cl00519 446465005443 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 446465005444 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 446465005445 active site 446465005446 (T/H)XGH motif; other site 446465005447 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 446465005448 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 446465005449 putative catalytic cysteine [active] 446465005450 gamma-glutamyl kinase; Provisional; Region: PRK05429 446465005451 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 446465005452 nucleotide binding site [chemical binding]; other site 446465005453 homotetrameric interface [polypeptide binding]; other site 446465005454 putative phosphate binding site [ion binding]; other site 446465005455 putative allosteric binding site; other site 446465005456 PUA domain; Region: PUA; pfam01472 446465005457 GTPase CgtA; Reviewed; Region: obgE; PRK12296 446465005458 GTP1/OBG; Region: GTP1_OBG; pfam01018 446465005459 Obg GTPase; Region: Obg; cd01898 446465005460 G1 box; other site 446465005461 GTP/Mg2+ binding site [chemical binding]; other site 446465005462 Switch I region; other site 446465005463 G2 box; other site 446465005464 G3 box; other site 446465005465 Switch II region; other site 446465005466 G4 box; other site 446465005467 G5 box; other site 446465005468 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 446465005469 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 446465005470 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 446465005471 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 446465005472 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 446465005473 homodimer interface [polypeptide binding]; other site 446465005474 oligonucleotide binding site [chemical binding]; other site 446465005475 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 446465005476 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446465005477 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 446465005478 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465005479 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 446465005480 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 446465005481 Walker A/P-loop; other site 446465005482 ATP binding site [chemical binding]; other site 446465005483 Q-loop/lid; other site 446465005484 ABC transporter signature motif; other site 446465005485 Walker B; other site 446465005486 D-loop; other site 446465005487 H-loop/switch region; other site 446465005488 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 446465005489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465005490 Walker A/P-loop; other site 446465005491 ATP binding site [chemical binding]; other site 446465005492 Q-loop/lid; other site 446465005493 ABC transporter signature motif; other site 446465005494 Walker B; other site 446465005495 D-loop; other site 446465005496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446465005497 Histidine kinase; Region: HisKA_3; pfam07730 446465005498 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465005499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465005500 active site 446465005501 phosphorylation site [posttranslational modification] 446465005502 intermolecular recognition site; other site 446465005503 dimerization interface [polypeptide binding]; other site 446465005504 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446465005505 DNA binding residues [nucleotide binding] 446465005506 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 446465005507 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 446465005508 DNA binding site [nucleotide binding] 446465005509 catalytic residue [active] 446465005510 H2TH interface [polypeptide binding]; other site 446465005511 putative catalytic residues [active] 446465005512 turnover-facilitating residue; other site 446465005513 intercalation triad [nucleotide binding]; other site 446465005514 8OG recognition residue [nucleotide binding]; other site 446465005515 putative reading head residues; other site 446465005516 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446465005517 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446465005518 ribonuclease III; Reviewed; Region: rnc; PRK00102 446465005519 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 446465005520 dimerization interface [polypeptide binding]; other site 446465005521 active site 446465005522 metal binding site [ion binding]; metal-binding site 446465005523 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 446465005524 dsRNA binding site [nucleotide binding]; other site 446465005525 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 446465005526 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 446465005527 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 446465005528 active site 446465005529 (T/H)XGH motif; other site 446465005530 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 446465005531 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446465005532 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465005533 active site 446465005534 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 446465005535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465005536 S-adenosylmethionine binding site [chemical binding]; other site 446465005537 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 446465005538 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 446465005539 ssDNA binding site; other site 446465005540 generic binding surface II; other site 446465005541 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465005542 ATP binding site [chemical binding]; other site 446465005543 putative Mg++ binding site [ion binding]; other site 446465005544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465005545 nucleotide binding region [chemical binding]; other site 446465005546 ATP-binding site [chemical binding]; other site 446465005547 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 446465005548 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 446465005549 active site pocket [active] 446465005550 oxyanion hole [active] 446465005551 catalytic triad [active] 446465005552 active site nucleophile [active] 446465005553 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446465005554 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446465005555 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 446465005556 putative NAD(P) binding site [chemical binding]; other site 446465005557 putative substrate binding site [chemical binding]; other site 446465005558 catalytic Zn binding site [ion binding]; other site 446465005559 structural Zn binding site [ion binding]; other site 446465005560 dimer interface [polypeptide binding]; other site 446465005561 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 446465005562 dimerization interface [polypeptide binding]; other site 446465005563 thiamine monophosphate kinase; Provisional; Region: PRK05731 446465005564 ATP binding site [chemical binding]; other site 446465005565 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 446465005566 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 446465005567 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446465005568 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446465005569 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 446465005570 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 446465005571 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 446465005572 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446465005573 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446465005574 putative acyl-acceptor binding pocket; other site 446465005575 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 446465005576 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 446465005577 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 446465005578 hinge; other site 446465005579 active site 446465005580 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 446465005581 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 446465005582 substrate binding site [chemical binding]; other site 446465005583 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 446465005584 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 446465005585 substrate binding site [chemical binding]; other site 446465005586 ligand binding site [chemical binding]; other site 446465005587 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446465005588 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446465005589 Bacterial transcriptional regulator; Region: IclR; pfam01614 446465005590 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 446465005591 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 446465005592 HIGH motif; other site 446465005593 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 446465005594 active site 446465005595 KMSKS motif; other site 446465005596 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 446465005597 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 446465005598 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 446465005599 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 446465005600 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446465005601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465005602 ATP binding site [chemical binding]; other site 446465005603 putative Mg++ binding site [ion binding]; other site 446465005604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465005605 nucleotide binding region [chemical binding]; other site 446465005606 ATP-binding site [chemical binding]; other site 446465005607 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 446465005608 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 446465005609 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 446465005610 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 446465005611 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 446465005612 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 446465005613 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 446465005614 [4Fe-4S] binding site [ion binding]; other site 446465005615 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446465005616 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446465005617 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446465005618 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 446465005619 molybdopterin cofactor binding site; other site 446465005620 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 446465005621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465005622 putative substrate translocation pore; other site 446465005623 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 446465005624 ACT domain; Region: ACT_6; pfam13740 446465005625 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 446465005626 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 446465005627 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 446465005628 active site 446465005629 catalytic residues [active] 446465005630 metal binding site [ion binding]; metal-binding site 446465005631 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 446465005632 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 446465005633 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 446465005634 homodimer interface [polypeptide binding]; other site 446465005635 substrate-cofactor binding pocket; other site 446465005636 catalytic residue [active] 446465005637 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 446465005638 tartrate dehydrogenase; Region: TTC; TIGR02089 446465005639 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 446465005640 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 446465005641 ligand binding site [chemical binding]; other site 446465005642 NAD binding site [chemical binding]; other site 446465005643 dimerization interface [polypeptide binding]; other site 446465005644 catalytic site [active] 446465005645 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 446465005646 putative L-serine binding site [chemical binding]; other site 446465005647 ketol-acid reductoisomerase; Provisional; Region: PRK05479 446465005648 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 446465005649 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 446465005650 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 446465005651 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 446465005652 putative valine binding site [chemical binding]; other site 446465005653 dimer interface [polypeptide binding]; other site 446465005654 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 446465005655 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 446465005656 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446465005657 PYR/PP interface [polypeptide binding]; other site 446465005658 dimer interface [polypeptide binding]; other site 446465005659 TPP binding site [chemical binding]; other site 446465005660 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446465005661 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 446465005662 TPP-binding site [chemical binding]; other site 446465005663 dimer interface [polypeptide binding]; other site 446465005664 nitrite reductase subunit NirD; Provisional; Region: PRK14989 446465005665 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446465005666 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446465005667 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446465005668 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 446465005669 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 446465005670 active site 446465005671 SAM binding site [chemical binding]; other site 446465005672 homodimer interface [polypeptide binding]; other site 446465005673 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 446465005674 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 446465005675 putative active site [active] 446465005676 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 446465005677 active site 446465005678 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 446465005679 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 446465005680 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 446465005681 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 446465005682 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 446465005683 GatB domain; Region: GatB_Yqey; smart00845 446465005684 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446465005685 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 446465005686 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 446465005687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465005688 Coenzyme A binding pocket [chemical binding]; other site 446465005689 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 446465005690 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465005691 ATP binding site [chemical binding]; other site 446465005692 putative Mg++ binding site [ion binding]; other site 446465005693 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465005694 nucleotide binding region [chemical binding]; other site 446465005695 ATP-binding site [chemical binding]; other site 446465005696 Ligase N family; Region: LIGANc; smart00532 446465005697 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 446465005698 nucleotide binding pocket [chemical binding]; other site 446465005699 K-X-D-G motif; other site 446465005700 catalytic site [active] 446465005701 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 446465005702 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 446465005703 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 446465005704 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 446465005705 Dimer interface [polypeptide binding]; other site 446465005706 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 446465005707 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 446465005708 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 446465005709 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465005710 catalytic residue [active] 446465005711 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446465005712 metal ion-dependent adhesion site (MIDAS); other site 446465005713 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446465005714 metal ion-dependent adhesion site (MIDAS); other site 446465005715 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 446465005716 Protein of unknown function DUF58; Region: DUF58; pfam01882 446465005717 MoxR-like ATPases [General function prediction only]; Region: COG0714 446465005718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446465005719 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 446465005720 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 446465005721 active site 446465005722 catalytic site [active] 446465005723 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 446465005724 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 446465005725 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446465005726 active site 446465005727 homodimer interface [polypeptide binding]; other site 446465005728 catalytic site [active] 446465005729 acceptor binding site [chemical binding]; other site 446465005730 glycogen branching enzyme; Provisional; Region: PRK05402 446465005731 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 446465005732 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 446465005733 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 446465005734 active site 446465005735 catalytic site [active] 446465005736 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 446465005737 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 446465005738 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446465005739 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 446465005740 hypothetical protein; Provisional; Region: PRK03298 446465005741 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446465005742 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 446465005743 active site 446465005744 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 446465005745 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 446465005746 gamma subunit interface [polypeptide binding]; other site 446465005747 epsilon subunit interface [polypeptide binding]; other site 446465005748 LBP interface [polypeptide binding]; other site 446465005749 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 446465005750 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 446465005751 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 446465005752 alpha subunit interaction interface [polypeptide binding]; other site 446465005753 Walker A motif; other site 446465005754 ATP binding site [chemical binding]; other site 446465005755 Walker B motif; other site 446465005756 inhibitor binding site; inhibition site 446465005757 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446465005758 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 446465005759 core domain interface [polypeptide binding]; other site 446465005760 delta subunit interface [polypeptide binding]; other site 446465005761 epsilon subunit interface [polypeptide binding]; other site 446465005762 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 446465005763 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 446465005764 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 446465005765 beta subunit interaction interface [polypeptide binding]; other site 446465005766 Walker A motif; other site 446465005767 ATP binding site [chemical binding]; other site 446465005768 Walker B motif; other site 446465005769 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446465005770 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 446465005771 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 446465005772 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 446465005773 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 446465005774 ATP synthase subunit C; Region: ATP-synt_C; cl00466 446465005775 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 446465005776 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 446465005777 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 446465005778 Mg++ binding site [ion binding]; other site 446465005779 putative catalytic motif [active] 446465005780 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 446465005781 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 446465005782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465005783 S-adenosylmethionine binding site [chemical binding]; other site 446465005784 This domain is found in peptide chain release factors; Region: PCRF; smart00937 446465005785 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 446465005786 RF-1 domain; Region: RF-1; pfam00472 446465005787 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 446465005788 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465005789 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465005790 DNA binding site [nucleotide binding] 446465005791 domain linker motif; other site 446465005792 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465005793 dimerization interface [polypeptide binding]; other site 446465005794 ligand binding site [chemical binding]; other site 446465005795 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465005796 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465005797 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465005798 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465005799 active site 446465005800 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465005801 catalytic tetrad [active] 446465005802 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465005803 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465005804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465005805 dimer interface [polypeptide binding]; other site 446465005806 conserved gate region; other site 446465005807 putative PBP binding loops; other site 446465005808 ABC-ATPase subunit interface; other site 446465005809 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465005810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465005811 dimer interface [polypeptide binding]; other site 446465005812 conserved gate region; other site 446465005813 putative PBP binding loops; other site 446465005814 ABC-ATPase subunit interface; other site 446465005815 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 446465005816 transcription termination factor Rho; Provisional; Region: PRK12608 446465005817 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446465005818 RNA binding site [nucleotide binding]; other site 446465005819 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 446465005820 multimer interface [polypeptide binding]; other site 446465005821 Walker A motif; other site 446465005822 ATP binding site [chemical binding]; other site 446465005823 Walker B motif; other site 446465005824 homoserine kinase; Provisional; Region: PRK01212 446465005825 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 446465005826 threonine synthase; Reviewed; Region: PRK06721 446465005827 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 446465005828 homodimer interface [polypeptide binding]; other site 446465005829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465005830 catalytic residue [active] 446465005831 homoserine dehydrogenase; Provisional; Region: PRK06349 446465005832 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 446465005833 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 446465005834 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 446465005835 diaminopimelate decarboxylase; Region: lysA; TIGR01048 446465005836 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 446465005837 active site 446465005838 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446465005839 substrate binding site [chemical binding]; other site 446465005840 catalytic residues [active] 446465005841 dimer interface [polypeptide binding]; other site 446465005842 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 446465005843 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 446465005844 active site 446465005845 homotetramer interface [polypeptide binding]; other site 446465005846 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 446465005847 UGMP family protein; Validated; Region: PRK09604 446465005848 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 446465005849 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446465005850 Peptidase family M23; Region: Peptidase_M23; pfam01551 446465005851 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465005852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465005853 active site 446465005854 phosphorylation site [posttranslational modification] 446465005855 intermolecular recognition site; other site 446465005856 dimerization interface [polypeptide binding]; other site 446465005857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446465005858 DNA binding site [nucleotide binding] 446465005859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446465005860 dimerization interface [polypeptide binding]; other site 446465005861 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446465005862 dimer interface [polypeptide binding]; other site 446465005863 phosphorylation site [posttranslational modification] 446465005864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465005865 ATP binding site [chemical binding]; other site 446465005866 Mg2+ binding site [ion binding]; other site 446465005867 G-X-G motif; other site 446465005868 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 446465005869 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446465005870 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 446465005871 TPP-binding site [chemical binding]; other site 446465005872 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 446465005873 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446465005874 active site 446465005875 catalytic triad [active] 446465005876 oxyanion hole [active] 446465005877 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 446465005878 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 446465005879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446465005880 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446465005881 DNA binding residues [nucleotide binding] 446465005882 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 446465005883 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 446465005884 hinge; other site 446465005885 active site 446465005886 Predicted GTPases [General function prediction only]; Region: COG1162 446465005887 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 446465005888 GTPase/Zn-binding domain interface [polypeptide binding]; other site 446465005889 GTP/Mg2+ binding site [chemical binding]; other site 446465005890 G4 box; other site 446465005891 G5 box; other site 446465005892 G1 box; other site 446465005893 Switch I region; other site 446465005894 G2 box; other site 446465005895 G3 box; other site 446465005896 Switch II region; other site 446465005897 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446465005898 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 446465005899 active site 446465005900 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 446465005901 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 446465005902 active site 446465005903 ADP/pyrophosphate binding site [chemical binding]; other site 446465005904 allosteric effector site; other site 446465005905 fructose-1,6-bisphosphate binding site; other site 446465005906 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 446465005907 catalytic site [active] 446465005908 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 446465005909 active site 446465005910 catalytic triad [active] 446465005911 oxyanion hole [active] 446465005912 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 446465005913 Uncharacterized conserved protein [Function unknown]; Region: COG1615 446465005914 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 446465005915 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446465005916 dimer interface [polypeptide binding]; other site 446465005917 ssDNA binding site [nucleotide binding]; other site 446465005918 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446465005919 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 446465005920 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 446465005921 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 446465005922 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465005923 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 446465005924 ATP binding site [chemical binding]; other site 446465005925 putative Mg++ binding site [ion binding]; other site 446465005926 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465005927 nucleotide binding region [chemical binding]; other site 446465005928 ATP-binding site [chemical binding]; other site 446465005929 DEAD/H associated; Region: DEAD_assoc; pfam08494 446465005930 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 446465005931 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 446465005932 putative DNA binding site [nucleotide binding]; other site 446465005933 catalytic residue [active] 446465005934 putative H2TH interface [polypeptide binding]; other site 446465005935 putative catalytic residues [active] 446465005936 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446465005937 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 446465005938 catalytic site [active] 446465005939 putative active site [active] 446465005940 putative substrate binding site [chemical binding]; other site 446465005941 dimer interface [polypeptide binding]; other site 446465005942 dimerization interface [polypeptide binding]; other site 446465005943 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 446465005944 putative active cleft [active] 446465005945 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446465005946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465005947 Walker A/P-loop; other site 446465005948 ATP binding site [chemical binding]; other site 446465005949 Q-loop/lid; other site 446465005950 ABC transporter signature motif; other site 446465005951 Walker B; other site 446465005952 D-loop; other site 446465005953 H-loop/switch region; other site 446465005954 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465005955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465005956 DNA-binding site [nucleotide binding]; DNA binding site 446465005957 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446465005958 Domain of unknown function DUF77; Region: DUF77; pfam01910 446465005959 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 446465005960 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 446465005961 NAD binding site [chemical binding]; other site 446465005962 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446465005963 hydroxyglutarate oxidase; Provisional; Region: PRK11728 446465005964 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 446465005965 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 446465005966 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446465005967 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446465005968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465005969 putative DNA binding site [nucleotide binding]; other site 446465005970 putative Zn2+ binding site [ion binding]; other site 446465005971 Bacterial transcriptional regulator; Region: IclR; pfam01614 446465005972 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 446465005973 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446465005974 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 446465005975 FAD binding site [chemical binding]; other site 446465005976 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446465005977 synthetase active site [active] 446465005978 NTP binding site [chemical binding]; other site 446465005979 metal binding site [ion binding]; metal-binding site 446465005980 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446465005981 extended (e) SDRs; Region: SDR_e; cd08946 446465005982 NAD(P) binding site [chemical binding]; other site 446465005983 active site 446465005984 substrate binding site [chemical binding]; other site 446465005985 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446465005986 Cytochrome P450; Region: p450; cl12078 446465005987 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446465005988 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446465005989 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446465005990 metal-binding site [ion binding] 446465005991 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 446465005992 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446465005993 metal-binding site [ion binding] 446465005994 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446465005995 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 446465005996 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 446465005997 putative homodimer interface [polypeptide binding]; other site 446465005998 putative homotetramer interface [polypeptide binding]; other site 446465005999 putative allosteric switch controlling residues; other site 446465006000 putative metal binding site [ion binding]; other site 446465006001 putative homodimer-homodimer interface [polypeptide binding]; other site 446465006002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465006003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465006004 Isochorismatase family; Region: Isochorismatase; pfam00857 446465006005 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 446465006006 catalytic triad [active] 446465006007 conserved cis-peptide bond; other site 446465006008 oxidoreductase; Provisional; Region: PRK06128 446465006009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465006010 NAD(P) binding site [chemical binding]; other site 446465006011 active site 446465006012 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 446465006013 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446465006014 NAD binding site [chemical binding]; other site 446465006015 catalytic Zn binding site [ion binding]; other site 446465006016 structural Zn binding site [ion binding]; other site 446465006017 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 446465006018 Cation efflux family; Region: Cation_efflux; pfam01545 446465006019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446465006020 substrate binding pocket [chemical binding]; other site 446465006021 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 446465006022 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465006023 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465006024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465006025 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465006026 Walker A/P-loop; other site 446465006027 ATP binding site [chemical binding]; other site 446465006028 Q-loop/lid; other site 446465006029 ABC transporter signature motif; other site 446465006030 Walker B; other site 446465006031 D-loop; other site 446465006032 H-loop/switch region; other site 446465006033 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446465006034 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 446465006035 metal binding site [ion binding]; metal-binding site 446465006036 dimer interface [polypeptide binding]; other site 446465006037 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446465006038 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446465006039 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446465006040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465006041 NAD(P) binding site [chemical binding]; other site 446465006042 active site 446465006043 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446465006044 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446465006045 Coenzyme A binding pocket [chemical binding]; other site 446465006046 hypothetical protein; Provisional; Region: PRK04233 446465006047 SEC-C motif; Region: SEC-C; pfam02810 446465006048 short chain dehydrogenase; Provisional; Region: PRK07806 446465006049 NAD(P) binding site [chemical binding]; other site 446465006050 active site 446465006051 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465006052 catalytic core [active] 446465006053 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446465006054 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 446465006055 active site 446465006056 dimerization interface [polypeptide binding]; other site 446465006057 ribonuclease PH; Reviewed; Region: rph; PRK00173 446465006058 Ribonuclease PH; Region: RNase_PH_bact; cd11362 446465006059 hexamer interface [polypeptide binding]; other site 446465006060 active site 446465006061 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 446465006062 glutamate racemase; Provisional; Region: PRK00865 446465006063 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 446465006064 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 446465006065 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 446465006066 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 446465006067 active site 446465006068 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446465006069 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465006070 ATP binding site [chemical binding]; other site 446465006071 putative Mg++ binding site [ion binding]; other site 446465006072 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 446465006073 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446465006074 Beta-lactamase; Region: Beta-lactamase; pfam00144 446465006075 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465006076 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465006077 Walker A/P-loop; other site 446465006078 ATP binding site [chemical binding]; other site 446465006079 Q-loop/lid; other site 446465006080 ABC transporter signature motif; other site 446465006081 Walker B; other site 446465006082 D-loop; other site 446465006083 H-loop/switch region; other site 446465006084 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465006085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465006086 dimer interface [polypeptide binding]; other site 446465006087 conserved gate region; other site 446465006088 ABC-ATPase subunit interface; other site 446465006089 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465006090 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465006091 Walker A/P-loop; other site 446465006092 ATP binding site [chemical binding]; other site 446465006093 Q-loop/lid; other site 446465006094 ABC transporter signature motif; other site 446465006095 Walker B; other site 446465006096 D-loop; other site 446465006097 H-loop/switch region; other site 446465006098 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465006099 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465006100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465006101 dimer interface [polypeptide binding]; other site 446465006102 conserved gate region; other site 446465006103 putative PBP binding loops; other site 446465006104 ABC-ATPase subunit interface; other site 446465006105 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446465006106 substrate binding site [chemical binding]; other site 446465006107 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465006108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446465006109 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446465006110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465006111 Coenzyme A binding pocket [chemical binding]; other site 446465006112 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 446465006113 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446465006114 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 446465006115 Malic enzyme, N-terminal domain; Region: malic; pfam00390 446465006116 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 446465006117 NAD(P) binding pocket [chemical binding]; other site 446465006118 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 446465006119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465006120 ATP binding site [chemical binding]; other site 446465006121 putative Mg++ binding site [ion binding]; other site 446465006122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465006123 nucleotide binding region [chemical binding]; other site 446465006124 ATP-binding site [chemical binding]; other site 446465006125 Helicase associated domain (HA2); Region: HA2; pfam04408 446465006126 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 446465006127 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 446465006128 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 446465006129 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446465006130 Phosphotransferase enzyme family; Region: APH; pfam01636 446465006131 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446465006132 active site 446465006133 ATP binding site [chemical binding]; other site 446465006134 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446465006135 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446465006136 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446465006137 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446465006138 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 446465006139 SmpB-tmRNA interface; other site 446465006140 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446465006141 Peptidase family M23; Region: Peptidase_M23; pfam01551 446465006142 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 446465006143 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 446465006144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465006145 Walker A/P-loop; other site 446465006146 ATP binding site [chemical binding]; other site 446465006147 Q-loop/lid; other site 446465006148 ABC transporter signature motif; other site 446465006149 Walker B; other site 446465006150 D-loop; other site 446465006151 H-loop/switch region; other site 446465006152 peptide chain release factor 2; Validated; Region: prfB; PRK00578 446465006153 This domain is found in peptide chain release factors; Region: PCRF; smart00937 446465006154 RF-1 domain; Region: RF-1; pfam00472 446465006155 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 446465006156 TadE-like protein; Region: TadE; pfam07811 446465006157 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 446465006158 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 446465006159 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 446465006160 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 446465006161 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 446465006162 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 446465006163 ATP binding site [chemical binding]; other site 446465006164 Walker A motif; other site 446465006165 hexamer interface [polypeptide binding]; other site 446465006166 Walker B motif; other site 446465006167 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 446465006168 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 446465006169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446465006170 Histidine kinase; Region: HisKA_3; pfam07730 446465006171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465006172 ATP binding site [chemical binding]; other site 446465006173 Mg2+ binding site [ion binding]; other site 446465006174 G-X-G motif; other site 446465006175 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465006176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465006177 active site 446465006178 phosphorylation site [posttranslational modification] 446465006179 intermolecular recognition site; other site 446465006180 dimerization interface [polypeptide binding]; other site 446465006181 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446465006182 DNA binding residues [nucleotide binding] 446465006183 dimerization interface [polypeptide binding]; other site 446465006184 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446465006185 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446465006186 Walker A/P-loop; other site 446465006187 ATP binding site [chemical binding]; other site 446465006188 Q-loop/lid; other site 446465006189 ABC transporter signature motif; other site 446465006190 Walker B; other site 446465006191 D-loop; other site 446465006192 H-loop/switch region; other site 446465006193 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446465006194 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446465006195 FtsX-like permease family; Region: FtsX; pfam02687 446465006196 FtsX-like permease family; Region: FtsX; pfam02687 446465006197 Transcription factor WhiB; Region: Whib; pfam02467 446465006198 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 446465006199 PAS fold; Region: PAS_4; pfam08448 446465006200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 446465006201 Histidine kinase; Region: HisKA_2; pfam07568 446465006202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465006203 Mg2+ binding site [ion binding]; other site 446465006204 G-X-G motif; other site 446465006205 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 446465006206 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 446465006207 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446465006208 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 446465006209 Helix-turn-helix domain; Region: HTH_17; pfam12728 446465006210 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 446465006211 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 446465006212 DEAD/DEAH box helicase; Region: DEAD; pfam00270 446465006213 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 446465006214 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 446465006215 30S subunit binding site; other site 446465006216 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 446465006217 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446465006218 active site 446465006219 lipoprotein LpqB; Provisional; Region: PRK13614 446465006220 Sporulation and spore germination; Region: Germane; pfam10646 446465006221 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446465006222 dimerization interface [polypeptide binding]; other site 446465006223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446465006224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446465006225 dimer interface [polypeptide binding]; other site 446465006226 phosphorylation site [posttranslational modification] 446465006227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465006228 ATP binding site [chemical binding]; other site 446465006229 Mg2+ binding site [ion binding]; other site 446465006230 G-X-G motif; other site 446465006231 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465006232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465006233 active site 446465006234 phosphorylation site [posttranslational modification] 446465006235 intermolecular recognition site; other site 446465006236 dimerization interface [polypeptide binding]; other site 446465006237 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446465006238 DNA binding site [nucleotide binding] 446465006239 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 446465006240 MoxR-like ATPases [General function prediction only]; Region: COG0714 446465006241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465006242 Walker A motif; other site 446465006243 ATP binding site [chemical binding]; other site 446465006244 Walker B motif; other site 446465006245 arginine finger; other site 446465006246 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446465006247 Protein of unknown function DUF58; Region: DUF58; pfam01882 446465006248 Phosphotransferase enzyme family; Region: APH; pfam01636 446465006249 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446465006250 active site 446465006251 ATP binding site [chemical binding]; other site 446465006252 substrate binding site [chemical binding]; other site 446465006253 Integral membrane protein DUF95; Region: DUF95; pfam01944 446465006254 RDD family; Region: RDD; pfam06271 446465006255 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 446465006256 active site 446465006257 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 446465006258 substrate binding site [chemical binding]; other site 446465006259 metal binding site [ion binding]; metal-binding site 446465006260 Trm112p-like protein; Region: Trm112p; cl01066 446465006261 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 446465006262 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 446465006263 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465006264 Transcription factor WhiB; Region: Whib; pfam02467 446465006265 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 446465006266 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 446465006267 TIGR03089 family protein; Region: TIGR03089 446465006268 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 446465006269 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 446465006270 Walker A/P-loop; other site 446465006271 ATP binding site [chemical binding]; other site 446465006272 Q-loop/lid; other site 446465006273 ABC transporter signature motif; other site 446465006274 Walker B; other site 446465006275 D-loop; other site 446465006276 H-loop/switch region; other site 446465006277 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446465006278 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446465006279 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465006280 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 446465006281 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446465006282 UDP-galactopyranose mutase; Region: GLF; pfam03275 446465006283 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465006284 active site 446465006285 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446465006286 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465006287 active site 446465006288 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 446465006289 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446465006290 Ligand binding site; other site 446465006291 Putative Catalytic site; other site 446465006292 DXD motif; other site 446465006293 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 446465006294 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446465006295 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446465006296 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 446465006297 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 446465006298 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446465006299 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 446465006300 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465006301 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 446465006302 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 446465006303 active site 446465006304 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 446465006305 homodimer interface [polypeptide binding]; other site 446465006306 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465006307 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465006308 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465006309 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 446465006310 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 446465006311 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 446465006312 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 446465006313 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465006314 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465006315 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465006316 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 446465006317 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446465006318 inhibitor-cofactor binding pocket; inhibition site 446465006319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465006320 catalytic residue [active] 446465006321 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 446465006322 putative trimer interface [polypeptide binding]; other site 446465006323 putative active site [active] 446465006324 putative substrate binding site [chemical binding]; other site 446465006325 putative CoA binding site [chemical binding]; other site 446465006326 Predicted membrane protein [Function unknown]; Region: COG4763 446465006327 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446465006328 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 446465006329 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 446465006330 ATP-grasp domain; Region: ATP-grasp; pfam02222 446465006331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446465006332 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 446465006333 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446465006334 dimer interface [polypeptide binding]; other site 446465006335 phosphorylation site [posttranslational modification] 446465006336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465006337 ATP binding site [chemical binding]; other site 446465006338 Mg2+ binding site [ion binding]; other site 446465006339 G-X-G motif; other site 446465006340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446465006341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465006342 active site 446465006343 phosphorylation site [posttranslational modification] 446465006344 intermolecular recognition site; other site 446465006345 dimerization interface [polypeptide binding]; other site 446465006346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446465006347 DNA binding site [nucleotide binding] 446465006348 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 446465006349 cyclase homology domain; Region: CHD; cd07302 446465006350 nucleotidyl binding site; other site 446465006351 metal binding site [ion binding]; metal-binding site 446465006352 dimer interface [polypeptide binding]; other site 446465006353 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 446465006354 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 446465006355 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 446465006356 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 446465006357 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446465006358 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446465006359 putative active site [active] 446465006360 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 446465006361 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 446465006362 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446465006363 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 446465006364 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 446465006365 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446465006366 carboxyltransferase (CT) interaction site; other site 446465006367 biotinylation site [posttranslational modification]; other site 446465006368 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 446465006369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446465006370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446465006371 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446465006372 purine nucleoside phosphorylase; Provisional; Region: PRK08202 446465006373 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 446465006374 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 446465006375 active site 446465006376 substrate binding site [chemical binding]; other site 446465006377 metal binding site [ion binding]; metal-binding site 446465006378 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 446465006379 intersubunit interface [polypeptide binding]; other site 446465006380 active site 446465006381 catalytic residue [active] 446465006382 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 446465006383 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 446465006384 putative NAD(P) binding site [chemical binding]; other site 446465006385 catalytic Zn binding site [ion binding]; other site 446465006386 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446465006387 active site 446465006388 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 446465006389 nudix motif; other site 446465006390 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 446465006391 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446465006392 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446465006393 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 446465006394 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 446465006395 active site 446465006396 catalytic motif [active] 446465006397 Zn binding site [ion binding]; other site 446465006398 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446465006399 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446465006400 TM-ABC transporter signature motif; other site 446465006401 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446465006402 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446465006403 TM-ABC transporter signature motif; other site 446465006404 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 446465006405 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446465006406 Walker A/P-loop; other site 446465006407 ATP binding site [chemical binding]; other site 446465006408 Q-loop/lid; other site 446465006409 ABC transporter signature motif; other site 446465006410 Walker B; other site 446465006411 D-loop; other site 446465006412 H-loop/switch region; other site 446465006413 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446465006414 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 446465006415 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 446465006416 ligand binding site [chemical binding]; other site 446465006417 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446465006418 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 446465006419 metal binding site [ion binding]; metal-binding site 446465006420 putative dimer interface [polypeptide binding]; other site 446465006421 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 446465006422 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 446465006423 Substrate binding site; other site 446465006424 Cupin domain; Region: Cupin_2; cl17218 446465006425 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 446465006426 putative Iron-sulfur protein interface [polypeptide binding]; other site 446465006427 putative proximal heme binding site [chemical binding]; other site 446465006428 putative SdhD-like interface [polypeptide binding]; other site 446465006429 putative distal heme binding site [chemical binding]; other site 446465006430 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 446465006431 putative Iron-sulfur protein interface [polypeptide binding]; other site 446465006432 putative proximal heme binding site [chemical binding]; other site 446465006433 putative SdhC-like subunit interface [polypeptide binding]; other site 446465006434 putative distal heme binding site [chemical binding]; other site 446465006435 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 446465006436 L-aspartate oxidase; Provisional; Region: PRK06175 446465006437 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446465006438 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 446465006439 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 446465006440 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 446465006441 putative active site [active] 446465006442 putative catalytic site [active] 446465006443 putative DNA binding site [nucleotide binding]; other site 446465006444 putative phosphate binding site [ion binding]; other site 446465006445 metal binding site A [ion binding]; metal-binding site 446465006446 putative AP binding site [nucleotide binding]; other site 446465006447 putative metal binding site B [ion binding]; other site 446465006448 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 446465006449 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 446465006450 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 446465006451 homodimer interface [polypeptide binding]; other site 446465006452 NADP binding site [chemical binding]; other site 446465006453 substrate binding site [chemical binding]; other site 446465006454 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 446465006455 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 446465006456 dimer interface [polypeptide binding]; other site 446465006457 active site 446465006458 glycine-pyridoxal phosphate binding site [chemical binding]; other site 446465006459 folate binding site [chemical binding]; other site 446465006460 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 446465006461 FAD binding domain; Region: FAD_binding_4; pfam01565 446465006462 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 446465006463 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446465006464 active site 2 [active] 446465006465 active site 1 [active] 446465006466 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 446465006467 active site 446465006468 catalytic site [active] 446465006469 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 446465006470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 446465006471 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 446465006472 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 446465006473 Proteins of 100 residues with WXG; Region: WXG100; cl02005 446465006474 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446465006475 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446465006476 phosphopeptide binding site; other site 446465006477 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 446465006478 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446465006479 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 446465006480 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446465006481 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446465006482 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465006483 active site 446465006484 ATP binding site [chemical binding]; other site 446465006485 substrate binding site [chemical binding]; other site 446465006486 activation loop (A-loop); other site 446465006487 FHA domain; Region: FHA; pfam00498 446465006488 phosphopeptide binding site; other site 446465006489 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446465006490 active site 446465006491 RDD family; Region: RDD; pfam06271 446465006492 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446465006493 phosphopeptide binding site; other site 446465006494 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 446465006495 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 446465006496 Protein of unknown function DUF58; Region: DUF58; pfam01882 446465006497 MoxR-like ATPases [General function prediction only]; Region: COG0714 446465006498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465006499 Walker A motif; other site 446465006500 ATP binding site [chemical binding]; other site 446465006501 Walker B motif; other site 446465006502 arginine finger; other site 446465006503 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 446465006504 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446465006505 Interdomain contacts; other site 446465006506 Cytokine receptor motif; other site 446465006507 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446465006508 Interdomain contacts; other site 446465006509 Cytokine receptor motif; other site 446465006510 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 446465006511 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446465006512 Interdomain contacts; other site 446465006513 Cytokine receptor motif; other site 446465006514 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446465006515 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446465006516 substrate binding pocket [chemical binding]; other site 446465006517 chain length determination region; other site 446465006518 substrate-Mg2+ binding site; other site 446465006519 catalytic residues [active] 446465006520 aspartate-rich region 1; other site 446465006521 active site lid residues [active] 446465006522 aspartate-rich region 2; other site 446465006523 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 446465006524 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 446465006525 active site 446465006526 HIGH motif; other site 446465006527 dimer interface [polypeptide binding]; other site 446465006528 KMSKS motif; other site 446465006529 argininosuccinate lyase; Provisional; Region: PRK00855 446465006530 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 446465006531 active sites [active] 446465006532 tetramer interface [polypeptide binding]; other site 446465006533 argininosuccinate synthase; Provisional; Region: PRK13820 446465006534 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 446465006535 ANP binding site [chemical binding]; other site 446465006536 Substrate Binding Site II [chemical binding]; other site 446465006537 Substrate Binding Site I [chemical binding]; other site 446465006538 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 446465006539 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 446465006540 ornithine carbamoyltransferase; Provisional; Region: PRK00779 446465006541 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446465006542 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 446465006543 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 446465006544 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446465006545 inhibitor-cofactor binding pocket; inhibition site 446465006546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465006547 catalytic residue [active] 446465006548 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 446465006549 feedback inhibition sensing region; other site 446465006550 homohexameric interface [polypeptide binding]; other site 446465006551 nucleotide binding site [chemical binding]; other site 446465006552 N-acetyl-L-glutamate binding site [chemical binding]; other site 446465006553 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 446465006554 heterotetramer interface [polypeptide binding]; other site 446465006555 active site pocket [active] 446465006556 cleavage site 446465006557 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 446465006558 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 446465006559 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446465006560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465006561 dimer interface [polypeptide binding]; other site 446465006562 conserved gate region; other site 446465006563 putative PBP binding loops; other site 446465006564 ABC-ATPase subunit interface; other site 446465006565 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465006566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465006567 dimer interface [polypeptide binding]; other site 446465006568 conserved gate region; other site 446465006569 putative PBP binding loops; other site 446465006570 ABC-ATPase subunit interface; other site 446465006571 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446465006572 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465006573 Walker A/P-loop; other site 446465006574 ATP binding site [chemical binding]; other site 446465006575 Q-loop/lid; other site 446465006576 ABC transporter signature motif; other site 446465006577 Walker B; other site 446465006578 D-loop; other site 446465006579 H-loop/switch region; other site 446465006580 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446465006581 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446465006582 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465006583 Walker A/P-loop; other site 446465006584 ATP binding site [chemical binding]; other site 446465006585 Q-loop/lid; other site 446465006586 ABC transporter signature motif; other site 446465006587 Walker B; other site 446465006588 D-loop; other site 446465006589 H-loop/switch region; other site 446465006590 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446465006591 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446465006592 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465006593 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 446465006594 active site 446465006595 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 446465006596 active site 446465006597 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 446465006598 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 446465006599 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 446465006600 active site 446465006601 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 446465006602 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 446465006603 putative tRNA-binding site [nucleotide binding]; other site 446465006604 B3/4 domain; Region: B3_4; pfam03483 446465006605 tRNA synthetase B5 domain; Region: B5; pfam03484 446465006606 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 446465006607 motif 3; other site 446465006608 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 446465006609 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 446465006610 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 446465006611 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 446465006612 dimer interface [polypeptide binding]; other site 446465006613 motif 1; other site 446465006614 active site 446465006615 motif 2; other site 446465006616 motif 3; other site 446465006617 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 446465006618 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 446465006619 NAD binding site [chemical binding]; other site 446465006620 catalytic Zn binding site [ion binding]; other site 446465006621 substrate binding site [chemical binding]; other site 446465006622 structural Zn binding site [ion binding]; other site 446465006623 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 446465006624 Copper resistance protein D; Region: CopD; pfam05425 446465006625 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 446465006626 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446465006627 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 446465006628 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446465006629 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 446465006630 23S rRNA binding site [nucleotide binding]; other site 446465006631 L21 binding site [polypeptide binding]; other site 446465006632 L13 binding site [polypeptide binding]; other site 446465006633 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 446465006634 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 446465006635 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 446465006636 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 446465006637 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 446465006638 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 446465006639 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 446465006640 catalytic residues [active] 446465006641 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 446465006642 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 446465006643 putative active site [active] 446465006644 oxyanion strand; other site 446465006645 catalytic triad [active] 446465006646 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 446465006647 4-fold oligomerization interface [polypeptide binding]; other site 446465006648 putative active site pocket [active] 446465006649 metal binding residues [ion binding]; metal-binding site 446465006650 3-fold/trimer interface [polypeptide binding]; other site 446465006651 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 446465006652 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465006653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465006654 homodimer interface [polypeptide binding]; other site 446465006655 catalytic residue [active] 446465006656 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 446465006657 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 446465006658 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 446465006659 NAD binding site [chemical binding]; other site 446465006660 dimerization interface [polypeptide binding]; other site 446465006661 product binding site; other site 446465006662 substrate binding site [chemical binding]; other site 446465006663 zinc binding site [ion binding]; other site 446465006664 catalytic residues [active] 446465006665 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 446465006666 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 446465006667 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 446465006668 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446465006669 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446465006670 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465006671 active site 446465006672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465006673 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465006674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465006675 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465006676 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 446465006677 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 446465006678 heme-binding site [chemical binding]; other site 446465006679 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 446465006680 FAD binding pocket [chemical binding]; other site 446465006681 FAD binding motif [chemical binding]; other site 446465006682 phosphate binding motif [ion binding]; other site 446465006683 beta-alpha-beta structure motif; other site 446465006684 NAD binding pocket [chemical binding]; other site 446465006685 Heme binding pocket [chemical binding]; other site 446465006686 Protein of unknown function, DUF488; Region: DUF488; cl01246 446465006687 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 446465006688 dimer interface [polypeptide binding]; other site 446465006689 catalytic triad [active] 446465006690 peroxidatic and resolving cysteines [active] 446465006691 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 446465006692 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446465006693 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 446465006694 active site 446465006695 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 446465006696 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 446465006697 putative phosphoketolase; Provisional; Region: PRK05261 446465006698 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 446465006699 TPP-binding site; other site 446465006700 XFP C-terminal domain; Region: XFP_C; pfam09363 446465006701 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 446465006702 Acylphosphatase; Region: Acylphosphatase; pfam00708 446465006703 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446465006704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465006705 putative substrate translocation pore; other site 446465006706 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 446465006707 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446465006708 NAD(P) binding site [chemical binding]; other site 446465006709 putative active site [active] 446465006710 Protein of unknown function (DUF808); Region: DUF808; cl01002 446465006711 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 446465006712 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446465006713 active site 446465006714 BCCT family transporter; Region: BCCT; pfam02028 446465006715 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446465006716 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446465006717 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446465006718 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 446465006719 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 446465006720 putative substrate binding site [chemical binding]; other site 446465006721 putative ATP binding site [chemical binding]; other site 446465006722 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 446465006723 active site 446465006724 phosphorylation site [posttranslational modification] 446465006725 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 446465006726 active site 446465006727 P-loop; other site 446465006728 phosphorylation site [posttranslational modification] 446465006729 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 446465006730 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 446465006731 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 446465006732 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 446465006733 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 446465006734 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 446465006735 active site 446465006736 SUMO-1 interface [polypeptide binding]; other site 446465006737 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 446465006738 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446465006739 dimer interface [polypeptide binding]; other site 446465006740 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 446465006741 Phosphotransferase enzyme family; Region: APH; pfam01636 446465006742 putative active site [active] 446465006743 putative substrate binding site [chemical binding]; other site 446465006744 ATP binding site [chemical binding]; other site 446465006745 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 446465006746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465006747 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465006748 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465006749 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465006750 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465006751 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465006752 SurA N-terminal domain; Region: SurA_N_3; cl07813 446465006753 Uncharacterized conserved protein [Function unknown]; Region: COG1359 446465006754 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 446465006755 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 446465006756 gating phenylalanine in ion channel; other site 446465006757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465006758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446465006759 putative substrate translocation pore; other site 446465006760 BCCT family transporter; Region: BCCT; cl00569 446465006761 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 446465006762 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446465006763 tetramerization interface [polypeptide binding]; other site 446465006764 NAD(P) binding site [chemical binding]; other site 446465006765 catalytic residues [active] 446465006766 choline dehydrogenase; Validated; Region: PRK02106 446465006767 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446465006768 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446465006769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446465006770 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446465006771 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446465006772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 446465006773 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 446465006774 active site 446465006775 catalytic site [active] 446465006776 Sulfatase; Region: Sulfatase; cl17466 446465006777 choline-sulfatase; Region: chol_sulfatase; TIGR03417 446465006778 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 446465006779 BCCT family transporter; Region: BCCT; pfam02028 446465006780 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 446465006781 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 446465006782 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 446465006783 aromatic arch; other site 446465006784 DCoH dimer interaction site [polypeptide binding]; other site 446465006785 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 446465006786 DCoH tetramer interaction site [polypeptide binding]; other site 446465006787 substrate binding site [chemical binding]; other site 446465006788 hypothetical protein; Provisional; Region: PRK09256 446465006789 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446465006790 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 446465006791 putative acyl-acceptor binding pocket; other site 446465006792 Protein of unknown function (DUF429); Region: DUF429; pfam04250 446465006793 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 446465006794 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 446465006795 active site 446465006796 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446465006797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465006798 dimer interface [polypeptide binding]; other site 446465006799 conserved gate region; other site 446465006800 putative PBP binding loops; other site 446465006801 ABC-ATPase subunit interface; other site 446465006802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465006803 dimer interface [polypeptide binding]; other site 446465006804 conserved gate region; other site 446465006805 putative PBP binding loops; other site 446465006806 ABC-ATPase subunit interface; other site 446465006807 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446465006808 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446465006809 substrate binding pocket [chemical binding]; other site 446465006810 membrane-bound complex binding site; other site 446465006811 hinge residues; other site 446465006812 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446465006813 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446465006814 Walker A/P-loop; other site 446465006815 ATP binding site [chemical binding]; other site 446465006816 Q-loop/lid; other site 446465006817 ABC transporter signature motif; other site 446465006818 Walker B; other site 446465006819 D-loop; other site 446465006820 H-loop/switch region; other site 446465006821 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 446465006822 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 446465006823 putative active site [active] 446465006824 putative ligand binding site [chemical binding]; other site 446465006825 putative NAD(P) binding site [chemical binding]; other site 446465006826 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446465006827 glycosyltransferase, MGT family; Region: MGT; TIGR01426 446465006828 active site 446465006829 TDP-binding site; other site 446465006830 acceptor substrate-binding pocket; other site 446465006831 homodimer interface [polypeptide binding]; other site 446465006832 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 446465006833 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446465006834 RNA binding surface [nucleotide binding]; other site 446465006835 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 446465006836 active site 446465006837 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446465006838 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 446465006839 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 446465006840 PhnA protein; Region: PhnA; pfam03831 446465006841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465006842 dimerization interface [polypeptide binding]; other site 446465006843 putative DNA binding site [nucleotide binding]; other site 446465006844 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446465006845 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 446465006846 active site 446465006847 FMN binding site [chemical binding]; other site 446465006848 substrate binding site [chemical binding]; other site 446465006849 homotetramer interface [polypeptide binding]; other site 446465006850 catalytic residue [active] 446465006851 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 446465006852 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446465006853 NAD(P) binding site [chemical binding]; other site 446465006854 putative active site [active] 446465006855 Uncharacterized conserved protein [Function unknown]; Region: COG1359 446465006856 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 446465006857 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446465006858 Soluble P-type ATPase [General function prediction only]; Region: COG4087 446465006859 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465006860 dimerization interface [polypeptide binding]; other site 446465006861 putative DNA binding site [nucleotide binding]; other site 446465006862 putative Zn2+ binding site [ion binding]; other site 446465006863 GTP-binding protein YchF; Reviewed; Region: PRK09601 446465006864 YchF GTPase; Region: YchF; cd01900 446465006865 G1 box; other site 446465006866 GTP/Mg2+ binding site [chemical binding]; other site 446465006867 Switch I region; other site 446465006868 G2 box; other site 446465006869 Switch II region; other site 446465006870 G3 box; other site 446465006871 G4 box; other site 446465006872 G5 box; other site 446465006873 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 446465006874 RmuC family; Region: RmuC; pfam02646 446465006875 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 446465006876 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 446465006877 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 446465006878 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 446465006879 generic binding surface II; other site 446465006880 generic binding surface I; other site 446465006881 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 446465006882 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 446465006883 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 446465006884 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446465006885 putative substrate binding site [chemical binding]; other site 446465006886 putative ATP binding site [chemical binding]; other site 446465006887 fumarate hydratase; Reviewed; Region: fumC; PRK00485 446465006888 Class II fumarases; Region: Fumarase_classII; cd01362 446465006889 active site 446465006890 tetramer interface [polypeptide binding]; other site 446465006891 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 446465006892 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 446465006893 putative active site [active] 446465006894 PhoH-like protein; Region: PhoH; pfam02562 446465006895 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 446465006896 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 446465006897 catalytic residue [active] 446465006898 putative FPP diphosphate binding site; other site 446465006899 putative FPP binding hydrophobic cleft; other site 446465006900 dimer interface [polypeptide binding]; other site 446465006901 putative IPP diphosphate binding site; other site 446465006902 Haemolysin-III related; Region: HlyIII; pfam03006 446465006903 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 446465006904 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446465006905 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 446465006906 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 446465006907 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 446465006908 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 446465006909 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 446465006910 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 446465006911 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446465006912 Walker A/P-loop; other site 446465006913 ATP binding site [chemical binding]; other site 446465006914 Q-loop/lid; other site 446465006915 ABC transporter signature motif; other site 446465006916 Walker B; other site 446465006917 D-loop; other site 446465006918 H-loop/switch region; other site 446465006919 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446465006920 Coenzyme A binding pocket [chemical binding]; other site 446465006921 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 446465006922 Glycoprotease family; Region: Peptidase_M22; pfam00814 446465006923 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 446465006924 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 446465006925 alanine racemase; Reviewed; Region: alr; PRK00053 446465006926 active site 446465006927 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446465006928 dimer interface [polypeptide binding]; other site 446465006929 substrate binding site [chemical binding]; other site 446465006930 catalytic residues [active] 446465006931 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 446465006932 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446465006933 ATP binding site [chemical binding]; other site 446465006934 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 446465006935 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 446465006936 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 446465006937 glutaminase active site [active] 446465006938 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446465006939 dimer interface [polypeptide binding]; other site 446465006940 active site 446465006941 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 446465006942 dimer interface [polypeptide binding]; other site 446465006943 active site 446465006944 pantothenate kinase; Provisional; Region: PRK05439 446465006945 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 446465006946 ATP-binding site [chemical binding]; other site 446465006947 CoA-binding site [chemical binding]; other site 446465006948 Mg2+-binding site [ion binding]; other site 446465006949 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 446465006950 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 446465006951 active site 446465006952 substrate binding site [chemical binding]; other site 446465006953 metal binding site [ion binding]; metal-binding site 446465006954 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 446465006955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465006956 ATP binding site [chemical binding]; other site 446465006957 putative Mg++ binding site [ion binding]; other site 446465006958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446465006959 nucleotide binding region [chemical binding]; other site 446465006960 ATP-binding site [chemical binding]; other site 446465006961 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 446465006962 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 446465006963 23S rRNA interface [nucleotide binding]; other site 446465006964 L3 interface [polypeptide binding]; other site 446465006965 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 446465006966 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 446465006967 dimerization interface 3.5A [polypeptide binding]; other site 446465006968 active site 446465006969 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 446465006970 Predicted transcriptional regulator [Transcription]; Region: COG2345 446465006971 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 446465006972 putative DNA binding site [nucleotide binding]; other site 446465006973 putative Zn2+ binding site [ion binding]; other site 446465006974 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 446465006975 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 446465006976 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 446465006977 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 446465006978 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 446465006979 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 446465006980 ATP binding site [chemical binding]; other site 446465006981 active site 446465006982 substrate binding site [chemical binding]; other site 446465006983 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465006984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465006985 Walker A/P-loop; other site 446465006986 ATP binding site [chemical binding]; other site 446465006987 Q-loop/lid; other site 446465006988 ABC transporter signature motif; other site 446465006989 Walker B; other site 446465006990 D-loop; other site 446465006991 H-loop/switch region; other site 446465006992 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 446465006993 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446465006994 Walker A/P-loop; other site 446465006995 ATP binding site [chemical binding]; other site 446465006996 Q-loop/lid; other site 446465006997 ABC transporter signature motif; other site 446465006998 Walker B; other site 446465006999 D-loop; other site 446465007000 H-loop/switch region; other site 446465007001 Cobalt transport protein; Region: CbiQ; cl00463 446465007002 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 446465007003 YKOF-related Family; Region: Ykof; pfam07615 446465007004 YKOF-related Family; Region: Ykof; pfam07615 446465007005 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944 446465007006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446465007007 S-adenosylmethionine binding site [chemical binding]; other site 446465007008 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 446465007009 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446465007010 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 446465007011 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 446465007012 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 446465007013 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 446465007014 putative active site [active] 446465007015 catalytic triad [active] 446465007016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465007017 S-adenosylmethionine binding site [chemical binding]; other site 446465007018 Pirin-related protein [General function prediction only]; Region: COG1741 446465007019 Pirin; Region: Pirin; pfam02678 446465007020 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 446465007021 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 446465007022 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446465007023 DNA binding residues [nucleotide binding] 446465007024 dimer interface [polypeptide binding]; other site 446465007025 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 446465007026 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 446465007027 active site 446465007028 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446465007029 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465007030 active site 446465007031 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446465007032 active site 2 [active] 446465007033 active site 1 [active] 446465007034 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446465007035 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 446465007036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007037 NAD(P) binding site [chemical binding]; other site 446465007038 active site 446465007039 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 446465007040 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446465007041 dimer interface [polypeptide binding]; other site 446465007042 active site 446465007043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465007044 acyl-coenzyme A oxidase; Region: PLN02636 446465007045 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446465007046 active site 446465007047 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 446465007048 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 446465007049 dimerization interface [polypeptide binding]; other site 446465007050 ATP binding site [chemical binding]; other site 446465007051 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 446465007052 dimerization interface [polypeptide binding]; other site 446465007053 ATP binding site [chemical binding]; other site 446465007054 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 446465007055 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 446465007056 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 446465007057 alphaNTD homodimer interface [polypeptide binding]; other site 446465007058 alphaNTD - beta interaction site [polypeptide binding]; other site 446465007059 alphaNTD - beta' interaction site [polypeptide binding]; other site 446465007060 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 446465007061 30S ribosomal protein S11; Validated; Region: PRK05309 446465007062 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 446465007063 30S ribosomal protein S13; Region: bact_S13; TIGR03631 446465007064 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 446465007065 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 446465007066 rRNA binding site [nucleotide binding]; other site 446465007067 predicted 30S ribosome binding site; other site 446465007068 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446465007069 active site 446465007070 adenylate kinase; Reviewed; Region: adk; PRK00279 446465007071 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 446465007072 AMP-binding site [chemical binding]; other site 446465007073 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 446465007074 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 446465007075 SecY translocase; Region: SecY; pfam00344 446465007076 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 446465007077 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 446465007078 23S rRNA binding site [nucleotide binding]; other site 446465007079 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 446465007080 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 446465007081 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 446465007082 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 446465007083 5S rRNA interface [nucleotide binding]; other site 446465007084 23S rRNA interface [nucleotide binding]; other site 446465007085 L5 interface [polypeptide binding]; other site 446465007086 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 446465007087 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446465007088 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446465007089 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 446465007090 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 446465007091 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 446465007092 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 446465007093 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 446465007094 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 446465007095 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 446465007096 RNA binding site [nucleotide binding]; other site 446465007097 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 446465007098 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 446465007099 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 446465007100 L23 interface [polypeptide binding]; other site 446465007101 signal recognition particle (SRP54) interaction site; other site 446465007102 trigger factor interaction site; other site 446465007103 23S rRNA interface [nucleotide binding]; other site 446465007104 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 446465007105 23S rRNA interface [nucleotide binding]; other site 446465007106 5S rRNA interface [nucleotide binding]; other site 446465007107 putative antibiotic binding site [chemical binding]; other site 446465007108 L25 interface [polypeptide binding]; other site 446465007109 L27 interface [polypeptide binding]; other site 446465007110 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 446465007111 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 446465007112 G-X-X-G motif; other site 446465007113 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 446465007114 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 446465007115 putative translocon binding site; other site 446465007116 protein-rRNA interface [nucleotide binding]; other site 446465007117 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 446465007118 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 446465007119 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 446465007120 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 446465007121 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 446465007122 50S ribosomal protein L4; Provisional; Region: rplD; PRK14547 446465007123 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 446465007124 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 446465007125 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465007126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007127 dimer interface [polypeptide binding]; other site 446465007128 conserved gate region; other site 446465007129 putative PBP binding loops; other site 446465007130 ABC-ATPase subunit interface; other site 446465007131 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446465007132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007133 dimer interface [polypeptide binding]; other site 446465007134 conserved gate region; other site 446465007135 putative PBP binding loops; other site 446465007136 ABC-ATPase subunit interface; other site 446465007137 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 446465007138 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465007139 elongation factor Tu; Reviewed; Region: PRK00049 446465007140 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 446465007141 G1 box; other site 446465007142 GEF interaction site [polypeptide binding]; other site 446465007143 GTP/Mg2+ binding site [chemical binding]; other site 446465007144 Switch I region; other site 446465007145 G2 box; other site 446465007146 G3 box; other site 446465007147 Switch II region; other site 446465007148 G4 box; other site 446465007149 G5 box; other site 446465007150 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 446465007151 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 446465007152 Antibiotic Binding Site [chemical binding]; other site 446465007153 elongation factor G; Reviewed; Region: PRK00007 446465007154 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 446465007155 G1 box; other site 446465007156 putative GEF interaction site [polypeptide binding]; other site 446465007157 GTP/Mg2+ binding site [chemical binding]; other site 446465007158 Switch I region; other site 446465007159 G2 box; other site 446465007160 G3 box; other site 446465007161 Switch II region; other site 446465007162 G4 box; other site 446465007163 G5 box; other site 446465007164 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 446465007165 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 446465007166 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 446465007167 30S ribosomal protein S7; Validated; Region: PRK05302 446465007168 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 446465007169 S17 interaction site [polypeptide binding]; other site 446465007170 S8 interaction site; other site 446465007171 16S rRNA interaction site [nucleotide binding]; other site 446465007172 streptomycin interaction site [chemical binding]; other site 446465007173 23S rRNA interaction site [nucleotide binding]; other site 446465007174 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 446465007175 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446465007176 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446465007177 G5 domain; Region: G5; pfam07501 446465007178 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 446465007179 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 446465007180 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 446465007181 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 446465007182 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 446465007183 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 446465007184 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 446465007185 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 446465007186 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 446465007187 DNA binding site [nucleotide binding] 446465007188 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 446465007189 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 446465007190 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 446465007191 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 446465007192 RPB10 interaction site [polypeptide binding]; other site 446465007193 RPB1 interaction site [polypeptide binding]; other site 446465007194 RPB11 interaction site [polypeptide binding]; other site 446465007195 RPB3 interaction site [polypeptide binding]; other site 446465007196 RPB12 interaction site [polypeptide binding]; other site 446465007197 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 446465007198 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 446465007199 putative active site [active] 446465007200 catalytic triad [active] 446465007201 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 446465007202 PA/protease or protease-like domain interface [polypeptide binding]; other site 446465007203 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 446465007204 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 446465007205 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 446465007206 L11 interface [polypeptide binding]; other site 446465007207 putative EF-Tu interaction site [polypeptide binding]; other site 446465007208 putative EF-G interaction site [polypeptide binding]; other site 446465007209 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 446465007210 23S rRNA interface [nucleotide binding]; other site 446465007211 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 446465007212 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 446465007213 mRNA/rRNA interface [nucleotide binding]; other site 446465007214 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 446465007215 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 446465007216 23S rRNA interface [nucleotide binding]; other site 446465007217 L7/L12 interface [polypeptide binding]; other site 446465007218 putative thiostrepton binding site; other site 446465007219 L25 interface [polypeptide binding]; other site 446465007220 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 446465007221 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 446465007222 putative homodimer interface [polypeptide binding]; other site 446465007223 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 446465007224 heterodimer interface [polypeptide binding]; other site 446465007225 homodimer interface [polypeptide binding]; other site 446465007226 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 446465007227 aspartate aminotransferase; Provisional; Region: PRK05764 446465007228 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465007229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465007230 homodimer interface [polypeptide binding]; other site 446465007231 catalytic residue [active] 446465007232 adenosine deaminase; Provisional; Region: PRK09358 446465007233 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446465007234 active site 446465007235 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 446465007236 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 446465007237 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 446465007238 Uncharacterized conserved protein [Function unknown]; Region: COG2966 446465007239 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 446465007240 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 446465007241 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 446465007242 Aspartase; Region: Aspartase; cd01357 446465007243 active sites [active] 446465007244 tetramer interface [polypeptide binding]; other site 446465007245 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 446465007246 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 446465007247 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 446465007248 purine monophosphate binding site [chemical binding]; other site 446465007249 dimer interface [polypeptide binding]; other site 446465007250 putative catalytic residues [active] 446465007251 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 446465007252 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 446465007253 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 446465007254 active site 446465007255 substrate binding site [chemical binding]; other site 446465007256 cosubstrate binding site; other site 446465007257 catalytic site [active] 446465007258 Protein of unknown function (DUF3431); Region: DUF3431; pfam11913 446465007259 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446465007260 serine endoprotease; Provisional; Region: PRK10898 446465007261 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446465007262 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 446465007263 protein binding site [polypeptide binding]; other site 446465007264 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 446465007265 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 446465007266 dimer interface [polypeptide binding]; other site 446465007267 tetramer interface [polypeptide binding]; other site 446465007268 PYR/PP interface [polypeptide binding]; other site 446465007269 TPP binding site [chemical binding]; other site 446465007270 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 446465007271 O-succinylbenzoate synthase; Provisional; Region: PRK02901 446465007272 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 446465007273 active site 446465007274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446465007275 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 446465007276 substrate binding site [chemical binding]; other site 446465007277 oxyanion hole (OAH) forming residues; other site 446465007278 trimer interface [polypeptide binding]; other site 446465007279 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446465007280 acyl-activating enzyme (AAE) consensus motif; other site 446465007281 AMP binding site [chemical binding]; other site 446465007282 active site 446465007283 CoA binding site [chemical binding]; other site 446465007284 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 446465007285 UbiA prenyltransferase family; Region: UbiA; pfam01040 446465007286 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 446465007287 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 446465007288 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 446465007289 ResB-like family; Region: ResB; pfam05140 446465007290 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 446465007291 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 446465007292 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 446465007293 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446465007294 catalytic residues [active] 446465007295 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465007296 catalytic core [active] 446465007297 MarR family; Region: MarR; pfam01047 446465007298 YceI-like domain; Region: YceI; smart00867 446465007299 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 446465007300 YfjP GTPase; Region: YfjP; cd11383 446465007301 G1 box; other site 446465007302 GTP/Mg2+ binding site [chemical binding]; other site 446465007303 Switch I region; other site 446465007304 G2 box; other site 446465007305 Switch II region; other site 446465007306 G3 box; other site 446465007307 G4 box; other site 446465007308 G5 box; other site 446465007309 Protein of unknown function, DUF258; Region: DUF258; pfam03193 446465007310 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446465007311 G1 box; other site 446465007312 GTP/Mg2+ binding site [chemical binding]; other site 446465007313 G2 box; other site 446465007314 Switch I region; other site 446465007315 G3 box; other site 446465007316 Switch II region; other site 446465007317 G4 box; other site 446465007318 G5 box; other site 446465007319 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 446465007320 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 446465007321 active site 446465007322 Zn binding site [ion binding]; other site 446465007323 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 446465007324 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 446465007325 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446465007326 TrkA-N domain; Region: TrkA_N; pfam02254 446465007327 TrkA-C domain; Region: TrkA_C; pfam02080 446465007328 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 446465007329 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 446465007330 Domain of unknown function (DUF368); Region: DUF368; pfam04018 446465007331 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 446465007332 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446465007333 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 446465007334 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446465007335 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 446465007336 CopC domain; Region: CopC; pfam04234 446465007337 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 446465007338 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 446465007339 GTP binding site; other site 446465007340 Predicted amidohydrolase [General function prediction only]; Region: COG0388 446465007341 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 446465007342 active site 446465007343 catalytic triad [active] 446465007344 dimer interface [polypeptide binding]; other site 446465007345 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446465007346 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446465007347 ligand binding site [chemical binding]; other site 446465007348 flexible hinge region; other site 446465007349 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 446465007350 putative switch regulator; other site 446465007351 non-specific DNA interactions [nucleotide binding]; other site 446465007352 DNA binding site [nucleotide binding] 446465007353 sequence specific DNA binding site [nucleotide binding]; other site 446465007354 putative cAMP binding site [chemical binding]; other site 446465007355 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446465007356 metal-binding site [ion binding] 446465007357 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 446465007358 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446465007359 Soluble P-type ATPase [General function prediction only]; Region: COG4087 446465007360 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446465007361 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446465007362 putative NAD(P) binding site [chemical binding]; other site 446465007363 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446465007364 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446465007365 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446465007366 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 446465007367 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446465007368 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 446465007369 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 446465007370 Dienelactone hydrolase family; Region: DLH; pfam01738 446465007371 Serine hydrolase (FSH1); Region: FSH1; pfam03959 446465007372 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 446465007373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465007374 Walker A/P-loop; other site 446465007375 ATP binding site [chemical binding]; other site 446465007376 Q-loop/lid; other site 446465007377 ABC transporter signature motif; other site 446465007378 Walker B; other site 446465007379 D-loop; other site 446465007380 H-loop/switch region; other site 446465007381 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 446465007382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007383 dimer interface [polypeptide binding]; other site 446465007384 conserved gate region; other site 446465007385 putative PBP binding loops; other site 446465007386 ABC-ATPase subunit interface; other site 446465007387 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 446465007388 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 446465007389 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465007390 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465007391 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465007392 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465007393 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465007394 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465007395 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 446465007396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007397 dimer interface [polypeptide binding]; other site 446465007398 conserved gate region; other site 446465007399 putative PBP binding loops; other site 446465007400 ABC-ATPase subunit interface; other site 446465007401 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465007402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007403 dimer interface [polypeptide binding]; other site 446465007404 conserved gate region; other site 446465007405 putative PBP binding loops; other site 446465007406 ABC-ATPase subunit interface; other site 446465007407 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 446465007408 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446465007409 active site 446465007410 catalytic site [active] 446465007411 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 446465007412 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 446465007413 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446465007414 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 446465007415 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 446465007416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465007417 salt bridge; other site 446465007418 non-specific DNA binding site [nucleotide binding]; other site 446465007419 sequence-specific DNA binding site [nucleotide binding]; other site 446465007420 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465007421 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465007422 active site 446465007423 catalytic tetrad [active] 446465007424 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446465007425 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 446465007426 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 446465007427 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446465007428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465007429 Coenzyme A binding pocket [chemical binding]; other site 446465007430 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 446465007431 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446465007432 inhibitor-cofactor binding pocket; inhibition site 446465007433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465007434 catalytic residue [active] 446465007435 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 446465007436 Uncharacterized conserved protein [Function unknown]; Region: COG1739 446465007437 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 446465007438 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 446465007439 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 446465007440 dimer interface [polypeptide binding]; other site 446465007441 putative radical transfer pathway; other site 446465007442 diiron center [ion binding]; other site 446465007443 tyrosyl radical; other site 446465007444 Predicted membrane protein [Function unknown]; Region: COG2311 446465007445 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446465007446 Predicted transcriptional regulators [Transcription]; Region: COG1695 446465007447 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446465007448 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 446465007449 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 446465007450 Class I ribonucleotide reductase; Region: RNR_I; cd01679 446465007451 active site 446465007452 dimer interface [polypeptide binding]; other site 446465007453 catalytic residues [active] 446465007454 effector binding site; other site 446465007455 R2 peptide binding site; other site 446465007456 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 446465007457 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 446465007458 catalytic residues [active] 446465007459 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465007460 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465007461 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446465007462 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446465007463 putative acyl-acceptor binding pocket; other site 446465007464 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446465007465 Ligand Binding Site [chemical binding]; other site 446465007466 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 446465007467 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 446465007468 tetramer interface [polypeptide binding]; other site 446465007469 heme binding pocket [chemical binding]; other site 446465007470 NADPH binding site [chemical binding]; other site 446465007471 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446465007472 metal binding site 2 [ion binding]; metal-binding site 446465007473 putative DNA binding helix; other site 446465007474 metal binding site 1 [ion binding]; metal-binding site 446465007475 dimer interface [polypeptide binding]; other site 446465007476 structural Zn2+ binding site [ion binding]; other site 446465007477 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 446465007478 classical (c) SDRs; Region: SDR_c; cd05233 446465007479 NAD(P) binding site [chemical binding]; other site 446465007480 active site 446465007481 short chain dehydrogenase; Provisional; Region: PRK07454 446465007482 classical (c) SDRs; Region: SDR_c; cd05233 446465007483 NAD(P) binding site [chemical binding]; other site 446465007484 active site 446465007485 TAP-like protein; Region: Abhydrolase_4; pfam08386 446465007486 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446465007487 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 446465007488 Walker A/P-loop; other site 446465007489 ATP binding site [chemical binding]; other site 446465007490 Q-loop/lid; other site 446465007491 ABC transporter signature motif; other site 446465007492 Walker B; other site 446465007493 D-loop; other site 446465007494 H-loop/switch region; other site 446465007495 Histidine kinase; Region: HisKA_3; pfam07730 446465007496 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446465007497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446465007498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465007499 active site 446465007500 phosphorylation site [posttranslational modification] 446465007501 intermolecular recognition site; other site 446465007502 dimerization interface [polypeptide binding]; other site 446465007503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446465007504 DNA binding residues [nucleotide binding] 446465007505 dimerization interface [polypeptide binding]; other site 446465007506 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 446465007507 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 446465007508 Prostaglandin dehydrogenases; Region: PGDH; cd05288 446465007509 NAD(P) binding site [chemical binding]; other site 446465007510 substrate binding site [chemical binding]; other site 446465007511 dimer interface [polypeptide binding]; other site 446465007512 Predicted transcriptional regulators [Transcription]; Region: COG1695 446465007513 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446465007514 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 446465007515 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 446465007516 Potassium binding sites [ion binding]; other site 446465007517 Cesium cation binding sites [ion binding]; other site 446465007518 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 446465007519 Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism]; Region: MnhF; COG2212 446465007520 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 446465007521 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 446465007522 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446465007523 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 446465007524 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 446465007525 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446465007526 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 446465007527 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 446465007528 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 446465007529 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446465007530 trimer interface [polypeptide binding]; other site 446465007531 active site 446465007532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465007533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465007534 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446465007535 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446465007536 NHL repeat; Region: NHL; pfam01436 446465007537 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 446465007538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465007539 motif II; other site 446465007540 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 446465007541 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465007542 active site 446465007543 motif I; other site 446465007544 motif II; other site 446465007545 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 446465007546 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446465007547 homodimer interface [polypeptide binding]; other site 446465007548 substrate-cofactor binding pocket; other site 446465007549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465007550 catalytic residue [active] 446465007551 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446465007552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465007553 Walker A/P-loop; other site 446465007554 ATP binding site [chemical binding]; other site 446465007555 Q-loop/lid; other site 446465007556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 446465007557 ABC transporter signature motif; other site 446465007558 ABC transporter signature motif; other site 446465007559 Walker B; other site 446465007560 Walker B; other site 446465007561 D-loop; other site 446465007562 D-loop; other site 446465007563 H-loop/switch region; other site 446465007564 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446465007565 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 446465007566 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 446465007567 putative active site [active] 446465007568 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 446465007569 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446465007570 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446465007571 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 446465007572 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446465007573 E3 interaction surface; other site 446465007574 lipoyl attachment site [posttranslational modification]; other site 446465007575 e3 binding domain; Region: E3_binding; pfam02817 446465007576 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 446465007577 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446465007578 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446465007579 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446465007580 alpha subunit interface [polypeptide binding]; other site 446465007581 TPP binding site [chemical binding]; other site 446465007582 heterodimer interface [polypeptide binding]; other site 446465007583 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446465007584 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 446465007585 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446465007586 TPP-binding site [chemical binding]; other site 446465007587 heterodimer interface [polypeptide binding]; other site 446465007588 tetramer interface [polypeptide binding]; other site 446465007589 phosphorylation loop region [posttranslational modification] 446465007590 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 446465007591 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446465007592 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446465007593 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465007594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007595 dimer interface [polypeptide binding]; other site 446465007596 conserved gate region; other site 446465007597 putative PBP binding loops; other site 446465007598 ABC-ATPase subunit interface; other site 446465007599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007600 dimer interface [polypeptide binding]; other site 446465007601 conserved gate region; other site 446465007602 putative PBP binding loops; other site 446465007603 ABC-ATPase subunit interface; other site 446465007604 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465007605 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446465007606 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465007607 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465007608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465007609 putative substrate translocation pore; other site 446465007610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446465007611 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 446465007612 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465007613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465007614 homodimer interface [polypeptide binding]; other site 446465007615 catalytic residue [active] 446465007616 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446465007617 Membrane protein of unknown function; Region: DUF360; pfam04020 446465007618 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 446465007619 trehalose synthase; Region: treS_nterm; TIGR02456 446465007620 active site 446465007621 catalytic site [active] 446465007622 adenylosuccinate lyase; Provisional; Region: PRK09285 446465007623 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 446465007624 tetramer interface [polypeptide binding]; other site 446465007625 short chain dehydrogenase; Provisional; Region: PRK08219 446465007626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465007627 NAD(P) binding site [chemical binding]; other site 446465007628 active site 446465007629 CAAX protease self-immunity; Region: Abi; pfam02517 446465007630 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446465007631 active site residue [active] 446465007632 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446465007633 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446465007634 Walker A/P-loop; other site 446465007635 ATP binding site [chemical binding]; other site 446465007636 Q-loop/lid; other site 446465007637 ABC transporter signature motif; other site 446465007638 Walker B; other site 446465007639 D-loop; other site 446465007640 H-loop/switch region; other site 446465007641 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 446465007642 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 446465007643 Walker A/P-loop; other site 446465007644 ATP binding site [chemical binding]; other site 446465007645 Q-loop/lid; other site 446465007646 ABC transporter signature motif; other site 446465007647 Walker B; other site 446465007648 D-loop; other site 446465007649 H-loop/switch region; other site 446465007650 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 446465007651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007652 dimer interface [polypeptide binding]; other site 446465007653 conserved gate region; other site 446465007654 putative PBP binding loops; other site 446465007655 ABC-ATPase subunit interface; other site 446465007656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007657 dimer interface [polypeptide binding]; other site 446465007658 conserved gate region; other site 446465007659 putative PBP binding loops; other site 446465007660 ABC-ATPase subunit interface; other site 446465007661 PBP superfamily domain; Region: PBP_like_2; cl17296 446465007662 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 446465007663 active site 446465007664 Ap6A binding site [chemical binding]; other site 446465007665 nudix motif; other site 446465007666 metal binding site [ion binding]; metal-binding site 446465007667 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465007668 catalytic core [active] 446465007669 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 446465007670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465007671 Coenzyme A binding pocket [chemical binding]; other site 446465007672 nitrobindin heme-binding domain; Region: nitrobindin; cl10502 446465007673 heme-binding site [chemical binding]; other site 446465007674 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 446465007675 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 446465007676 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446465007677 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 446465007678 Predicted membrane protein [Function unknown]; Region: COG4129 446465007679 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 446465007680 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446465007681 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446465007682 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 446465007683 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 446465007684 active site 446465007685 intersubunit interface [polypeptide binding]; other site 446465007686 zinc binding site [ion binding]; other site 446465007687 Na+ binding site [ion binding]; other site 446465007688 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 446465007689 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446465007690 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446465007691 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 446465007692 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446465007693 active site 446465007694 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 446465007695 classical (c) SDRs; Region: SDR_c; cd05233 446465007696 NAD(P) binding site [chemical binding]; other site 446465007697 active site 446465007698 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 446465007699 putative catalytic site [active] 446465007700 putative phosphate binding site [ion binding]; other site 446465007701 active site 446465007702 metal binding site A [ion binding]; metal-binding site 446465007703 DNA binding site [nucleotide binding] 446465007704 putative AP binding site [nucleotide binding]; other site 446465007705 putative metal binding site B [ion binding]; other site 446465007706 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 446465007707 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446465007708 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 446465007709 Walker A motif; other site 446465007710 ATP binding site [chemical binding]; other site 446465007711 Walker B motif; other site 446465007712 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 446465007713 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 446465007714 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446465007715 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 446465007716 Protein of unknown function (DUF3223); Region: DUF3223; pfam11523 446465007717 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 446465007718 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 446465007719 catalytic residues [active] 446465007720 catalytic nucleophile [active] 446465007721 Presynaptic Site I dimer interface [polypeptide binding]; other site 446465007722 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 446465007723 Synaptic Flat tetramer interface [polypeptide binding]; other site 446465007724 Synaptic Site I dimer interface [polypeptide binding]; other site 446465007725 DNA binding site [nucleotide binding] 446465007726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465007727 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465007728 YaaC-like Protein; Region: YaaC; pfam14175 446465007729 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 446465007730 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446465007731 cofactor binding site; other site 446465007732 DNA binding site [nucleotide binding] 446465007733 substrate interaction site [chemical binding]; other site 446465007734 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446465007735 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 446465007736 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 446465007737 catalytic residues [active] 446465007738 catalytic nucleophile [active] 446465007739 Recombinase; Region: Recombinase; pfam07508 446465007740 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 446465007741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446465007742 ATP binding site [chemical binding]; other site 446465007743 putative Mg++ binding site [ion binding]; other site 446465007744 nucleotide binding region [chemical binding]; other site 446465007745 helicase superfamily c-terminal domain; Region: HELICc; smart00490 446465007746 ATP-binding site [chemical binding]; other site 446465007747 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 446465007748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465007749 S-adenosylmethionine binding site [chemical binding]; other site 446465007750 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 446465007751 active site 446465007752 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 446465007753 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 446465007754 active site 446465007755 interdomain interaction site; other site 446465007756 putative metal-binding site [ion binding]; other site 446465007757 nucleotide binding site [chemical binding]; other site 446465007758 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 446465007759 domain I; other site 446465007760 phosphate binding site [ion binding]; other site 446465007761 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 446465007762 domain II; other site 446465007763 domain III; other site 446465007764 nucleotide binding site [chemical binding]; other site 446465007765 DNA binding groove [nucleotide binding] 446465007766 catalytic site [active] 446465007767 domain IV; other site 446465007768 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446465007769 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446465007770 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446465007771 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446465007772 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446465007773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446465007774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007775 dimer interface [polypeptide binding]; other site 446465007776 conserved gate region; other site 446465007777 putative PBP binding loops; other site 446465007778 ABC-ATPase subunit interface; other site 446465007779 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465007780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007781 dimer interface [polypeptide binding]; other site 446465007782 conserved gate region; other site 446465007783 putative PBP binding loops; other site 446465007784 ABC-ATPase subunit interface; other site 446465007785 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465007786 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465007787 thymidylate kinase; Validated; Region: tmk; PRK00698 446465007788 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 446465007789 TMP-binding site; other site 446465007790 ATP-binding site [chemical binding]; other site 446465007791 DNA polymerase III subunit delta'; Validated; Region: PRK07940 446465007792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465007793 Walker A motif; other site 446465007794 ATP binding site [chemical binding]; other site 446465007795 Walker B motif; other site 446465007796 arginine finger; other site 446465007797 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 446465007798 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446465007799 DNA-binding site [nucleotide binding]; DNA binding site 446465007800 RNA-binding motif; other site 446465007801 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 446465007802 putative active site [active] 446465007803 putative CoA binding site [chemical binding]; other site 446465007804 nudix motif; other site 446465007805 metal binding site [ion binding]; metal-binding site 446465007806 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 446465007807 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446465007808 minor groove reading motif; other site 446465007809 helix-hairpin-helix signature motif; other site 446465007810 active site 446465007811 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 446465007812 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446465007813 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446465007814 ligand binding site [chemical binding]; other site 446465007815 flexible hinge region; other site 446465007816 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 446465007817 putative switch regulator; other site 446465007818 non-specific DNA interactions [nucleotide binding]; other site 446465007819 DNA binding site [nucleotide binding] 446465007820 sequence specific DNA binding site [nucleotide binding]; other site 446465007821 putative cAMP binding site [chemical binding]; other site 446465007822 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446465007823 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 446465007824 homotrimer interaction site [polypeptide binding]; other site 446465007825 putative active site [active] 446465007826 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 446465007827 Transcription factor WhiB; Region: Whib; pfam02467 446465007828 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 446465007829 Transglycosylase; Region: Transgly; pfam00912 446465007830 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446465007831 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446465007832 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446465007833 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446465007834 active site 446465007835 metal binding site [ion binding]; metal-binding site 446465007836 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446465007837 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446465007838 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446465007839 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446465007840 NlpC/P60 family; Region: NLPC_P60; pfam00877 446465007841 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 446465007842 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 446465007843 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 446465007844 active site 446465007845 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 446465007846 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 446465007847 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 446465007848 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 446465007849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 446465007850 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 446465007851 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 446465007852 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446465007853 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465007854 active site 446465007855 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446465007856 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446465007857 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 446465007858 substrate binding site; other site 446465007859 dimer interface; other site 446465007860 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 446465007861 classical (c) SDRs; Region: SDR_c; cd05233 446465007862 NAD(P) binding site [chemical binding]; other site 446465007863 active site 446465007864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 446465007865 Transposase; Region: DDE_Tnp_ISL3; pfam01610 446465007866 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 446465007867 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465007868 Walker A/P-loop; other site 446465007869 ATP binding site [chemical binding]; other site 446465007870 Q-loop/lid; other site 446465007871 ABC transporter signature motif; other site 446465007872 Walker B; other site 446465007873 D-loop; other site 446465007874 H-loop/switch region; other site 446465007875 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 446465007876 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446465007877 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446465007878 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446465007879 active site 446465007880 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 446465007881 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446465007882 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446465007883 active site 446465007884 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446465007885 YhhN-like protein; Region: YhhN; cl01505 446465007886 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446465007887 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446465007888 Walker A/P-loop; other site 446465007889 ATP binding site [chemical binding]; other site 446465007890 Q-loop/lid; other site 446465007891 ABC transporter signature motif; other site 446465007892 Walker B; other site 446465007893 D-loop; other site 446465007894 H-loop/switch region; other site 446465007895 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446465007896 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446465007897 FAD binding pocket [chemical binding]; other site 446465007898 FAD binding motif [chemical binding]; other site 446465007899 phosphate binding motif [ion binding]; other site 446465007900 NAD binding pocket [chemical binding]; other site 446465007901 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446465007902 ABC-ATPase subunit interface; other site 446465007903 dimer interface [polypeptide binding]; other site 446465007904 putative PBP binding regions; other site 446465007905 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446465007906 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446465007907 ABC-ATPase subunit interface; other site 446465007908 dimer interface [polypeptide binding]; other site 446465007909 putative PBP binding regions; other site 446465007910 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446465007911 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446465007912 intersubunit interface [polypeptide binding]; other site 446465007913 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 446465007914 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446465007915 active site 446465007916 DNA binding site [nucleotide binding] 446465007917 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 446465007918 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465007919 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446465007920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007921 dimer interface [polypeptide binding]; other site 446465007922 conserved gate region; other site 446465007923 putative PBP binding loops; other site 446465007924 ABC-ATPase subunit interface; other site 446465007925 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465007926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465007927 dimer interface [polypeptide binding]; other site 446465007928 conserved gate region; other site 446465007929 putative PBP binding loops; other site 446465007930 ABC-ATPase subunit interface; other site 446465007931 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 446465007932 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446465007933 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 446465007934 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 446465007935 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 446465007936 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 446465007937 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 446465007938 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446465007939 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 446465007940 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 446465007941 active site 446465007942 metal binding site [ion binding]; metal-binding site 446465007943 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446465007944 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 446465007945 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 446465007946 NAD(P) binding pocket [chemical binding]; other site 446465007947 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 446465007948 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 446465007949 substrate binding site [chemical binding]; other site 446465007950 active site 446465007951 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 446465007952 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 446465007953 ferrochelatase; Reviewed; Region: hemH; PRK00035 446465007954 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 446465007955 C-terminal domain interface [polypeptide binding]; other site 446465007956 active site 446465007957 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 446465007958 active site 446465007959 N-terminal domain interface [polypeptide binding]; other site 446465007960 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 446465007961 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 446465007962 domain interfaces; other site 446465007963 active site 446465007964 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 446465007965 active site 446465007966 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 446465007967 dimer interface [polypeptide binding]; other site 446465007968 active site 446465007969 Schiff base residues; other site 446465007970 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 446465007971 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446465007972 inhibitor-cofactor binding pocket; inhibition site 446465007973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465007974 catalytic residue [active] 446465007975 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465007976 active site 446465007977 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 446465007978 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446465007979 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 446465007980 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465007981 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 446465007982 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 446465007983 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446465007984 NAD binding site [chemical binding]; other site 446465007985 substrate binding site [chemical binding]; other site 446465007986 active site 446465007987 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 446465007988 dihydropteroate synthase; Region: DHPS; TIGR01496 446465007989 substrate binding pocket [chemical binding]; other site 446465007990 dimer interface [polypeptide binding]; other site 446465007991 inhibitor binding site; inhibition site 446465007992 Beta-lactamase; Region: Beta-lactamase; pfam00144 446465007993 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446465007994 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446465007995 Beta-lactamase; Region: Beta-lactamase; pfam00144 446465007996 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446465007997 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446465007998 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 446465007999 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446465008000 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446465008001 phosphopeptide binding site; other site 446465008002 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446465008003 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446465008004 phosphopeptide binding site; other site 446465008005 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446465008006 active site 446465008007 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 446465008008 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446465008009 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446465008010 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446465008011 active site 446465008012 ATP binding site [chemical binding]; other site 446465008013 substrate binding site [chemical binding]; other site 446465008014 activation loop (A-loop); other site 446465008015 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446465008016 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446465008017 active site 446465008018 ATP binding site [chemical binding]; other site 446465008019 substrate binding site [chemical binding]; other site 446465008020 activation loop (A-loop); other site 446465008021 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446465008022 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446465008023 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446465008024 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446465008025 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 446465008026 Glutamine amidotransferase class-I; Region: GATase; pfam00117 446465008027 glutamine binding [chemical binding]; other site 446465008028 catalytic triad [active] 446465008029 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 446465008030 active site 446465008031 catalytic site [active] 446465008032 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 446465008033 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465008034 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465008035 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446465008036 conserved cys residue [active] 446465008037 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446465008038 catalytic core [active] 446465008039 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446465008040 FAD binding domain; Region: FAD_binding_4; pfam01565 446465008041 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446465008042 putative acyl-acceptor binding pocket; other site 446465008043 classical (c) SDRs; Region: SDR_c; cd05233 446465008044 NAD(P) binding site [chemical binding]; other site 446465008045 active site 446465008046 fatty acyl-CoA reductase; Region: PLN02996 446465008047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465008048 NAD(P) binding site [chemical binding]; other site 446465008049 active site 446465008050 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 446465008051 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446465008052 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446465008053 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446465008054 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446465008055 Walker A/P-loop; other site 446465008056 ATP binding site [chemical binding]; other site 446465008057 Q-loop/lid; other site 446465008058 ABC transporter signature motif; other site 446465008059 Walker B; other site 446465008060 D-loop; other site 446465008061 H-loop/switch region; other site 446465008062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008063 dimer interface [polypeptide binding]; other site 446465008064 conserved gate region; other site 446465008065 putative PBP binding loops; other site 446465008066 ABC-ATPase subunit interface; other site 446465008067 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446465008068 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446465008069 substrate binding pocket [chemical binding]; other site 446465008070 membrane-bound complex binding site; other site 446465008071 hinge residues; other site 446465008072 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 446465008073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465008074 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 446465008075 Walker A/P-loop; other site 446465008076 ATP binding site [chemical binding]; other site 446465008077 Q-loop/lid; other site 446465008078 ABC transporter signature motif; other site 446465008079 Walker B; other site 446465008080 D-loop; other site 446465008081 H-loop/switch region; other site 446465008082 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465008083 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465008084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465008085 Walker A/P-loop; other site 446465008086 ATP binding site [chemical binding]; other site 446465008087 Q-loop/lid; other site 446465008088 ABC transporter signature motif; other site 446465008089 Walker B; other site 446465008090 D-loop; other site 446465008091 H-loop/switch region; other site 446465008092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465008093 S-adenosylmethionine binding site [chemical binding]; other site 446465008094 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465008095 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465008096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465008097 Walker A/P-loop; other site 446465008098 ATP binding site [chemical binding]; other site 446465008099 Q-loop/lid; other site 446465008100 ABC transporter signature motif; other site 446465008101 Walker B; other site 446465008102 D-loop; other site 446465008103 H-loop/switch region; other site 446465008104 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465008105 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465008106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465008107 Walker A/P-loop; other site 446465008108 ATP binding site [chemical binding]; other site 446465008109 Q-loop/lid; other site 446465008110 ABC transporter signature motif; other site 446465008111 Walker B; other site 446465008112 D-loop; other site 446465008113 H-loop/switch region; other site 446465008114 Protein of unknown function (DUF456); Region: DUF456; pfam04306 446465008115 VanZ like family; Region: VanZ; pfam04892 446465008116 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 446465008117 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 446465008118 dimer interface [polypeptide binding]; other site 446465008119 active site 446465008120 CoA binding pocket [chemical binding]; other site 446465008121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465008122 AAA domain; Region: AAA_23; pfam13476 446465008123 Walker A/P-loop; other site 446465008124 ATP binding site [chemical binding]; other site 446465008125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465008126 Q-loop/lid; other site 446465008127 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 446465008128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465008129 ABC transporter signature motif; other site 446465008130 Walker B; other site 446465008131 D-loop; other site 446465008132 H-loop/switch region; other site 446465008133 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 446465008134 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 446465008135 active site 446465008136 metal binding site [ion binding]; metal-binding site 446465008137 DNA binding site [nucleotide binding] 446465008138 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 446465008139 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 446465008140 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 446465008141 dimer interface [polypeptide binding]; other site 446465008142 substrate binding site [chemical binding]; other site 446465008143 ATP binding site [chemical binding]; other site 446465008144 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 446465008145 metabolite-proton symporter; Region: 2A0106; TIGR00883 446465008146 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 446465008147 substrate binding site [chemical binding]; other site 446465008148 multimerization interface [polypeptide binding]; other site 446465008149 ATP binding site [chemical binding]; other site 446465008150 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 446465008151 pyrophosphate binding site [ion binding]; other site 446465008152 active site 446465008153 thiamine phosphate binding site [chemical binding]; other site 446465008154 succinic semialdehyde dehydrogenase; Region: PLN02278 446465008155 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 446465008156 tetramerization interface [polypeptide binding]; other site 446465008157 NAD(P) binding site [chemical binding]; other site 446465008158 catalytic residues [active] 446465008159 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 446465008160 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 446465008161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446465008162 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446465008163 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465008164 hydrophobic ligand binding site; other site 446465008165 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 446465008166 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446465008167 active site 446465008168 metal binding site [ion binding]; metal-binding site 446465008169 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 446465008170 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446465008171 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446465008172 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 446465008173 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 446465008174 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446465008175 Protein of unknown function DUF58; Region: DUF58; pfam01882 446465008176 MoxR-like ATPases [General function prediction only]; Region: COG0714 446465008177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465008178 ATP binding site [chemical binding]; other site 446465008179 Walker A motif; other site 446465008180 Walker B motif; other site 446465008181 arginine finger; other site 446465008182 H+ Antiporter protein; Region: 2A0121; TIGR00900 446465008183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465008184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465008185 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465008186 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465008187 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465008188 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 446465008189 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 446465008190 active site 446465008191 nucleophile elbow; other site 446465008192 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 446465008193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446465008194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446465008195 dimer interface [polypeptide binding]; other site 446465008196 phosphorylation site [posttranslational modification] 446465008197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446465008198 ATP binding site [chemical binding]; other site 446465008199 Mg2+ binding site [ion binding]; other site 446465008200 G-X-G motif; other site 446465008201 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 446465008202 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 446465008203 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 446465008204 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446465008205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465008206 active site 446465008207 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 446465008208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446465008209 Response regulator receiver domain; Region: Response_reg; pfam00072 446465008210 active site 446465008211 phosphorylation site [posttranslational modification] 446465008212 intermolecular recognition site; other site 446465008213 dimerization interface [polypeptide binding]; other site 446465008214 HipA N-terminal domain; Region: Couple_hipA; pfam13657 446465008215 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 446465008216 HipA-like N-terminal domain; Region: HipA_N; pfam07805 446465008217 HipA-like C-terminal domain; Region: HipA_C; pfam07804 446465008218 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446465008219 Peptidase family M23; Region: Peptidase_M23; pfam01551 446465008220 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008221 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008222 DNA binding site [nucleotide binding] 446465008223 domain linker motif; other site 446465008224 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008225 ligand binding site [chemical binding]; other site 446465008226 dimerization interface [polypeptide binding]; other site 446465008227 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465008229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008230 dimer interface [polypeptide binding]; other site 446465008231 conserved gate region; other site 446465008232 putative PBP binding loops; other site 446465008233 ABC-ATPase subunit interface; other site 446465008234 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008236 dimer interface [polypeptide binding]; other site 446465008237 putative PBP binding loops; other site 446465008238 ABC-ATPase subunit interface; other site 446465008239 putative oxidoreductase; Provisional; Region: PRK11579 446465008240 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465008241 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465008242 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446465008243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 446465008244 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 446465008245 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446465008246 active site 446465008247 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465008248 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 446465008249 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465008250 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 446465008251 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446465008252 homodimer interface [polypeptide binding]; other site 446465008253 substrate-cofactor binding pocket; other site 446465008254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465008255 catalytic residue [active] 446465008256 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446465008257 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446465008258 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 446465008259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008260 dimer interface [polypeptide binding]; other site 446465008261 conserved gate region; other site 446465008262 putative PBP binding loops; other site 446465008263 ABC-ATPase subunit interface; other site 446465008264 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446465008265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008266 dimer interface [polypeptide binding]; other site 446465008267 conserved gate region; other site 446465008268 putative PBP binding loops; other site 446465008269 ABC-ATPase subunit interface; other site 446465008270 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465008271 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465008272 Walker A/P-loop; other site 446465008273 ATP binding site [chemical binding]; other site 446465008274 Q-loop/lid; other site 446465008275 ABC transporter signature motif; other site 446465008276 Walker B; other site 446465008277 D-loop; other site 446465008278 H-loop/switch region; other site 446465008279 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446465008280 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446465008281 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446465008282 Walker A/P-loop; other site 446465008283 ATP binding site [chemical binding]; other site 446465008284 Q-loop/lid; other site 446465008285 ABC transporter signature motif; other site 446465008286 Walker B; other site 446465008287 D-loop; other site 446465008288 H-loop/switch region; other site 446465008289 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446465008290 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 446465008291 active site 446465008292 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 446465008293 dimer interface [polypeptide binding]; other site 446465008294 non-prolyl cis peptide bond; other site 446465008295 insertion regions; other site 446465008296 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446465008297 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446465008298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446465008299 binding surface 446465008300 TPR motif; other site 446465008301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446465008302 binding surface 446465008303 TPR motif; other site 446465008304 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446465008305 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446465008306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465008307 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 446465008308 putative ADP-binding pocket [chemical binding]; other site 446465008309 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 446465008310 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 446465008311 active site 446465008312 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446465008313 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446465008314 active site 446465008315 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446465008316 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 446465008317 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 446465008318 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 446465008319 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 446465008320 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446465008321 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446465008322 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 446465008323 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 446465008324 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446465008325 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 446465008326 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 446465008327 active site 446465008328 homodimer interface [polypeptide binding]; other site 446465008329 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465008330 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 446465008331 Walker A/P-loop; other site 446465008332 ATP binding site [chemical binding]; other site 446465008333 Q-loop/lid; other site 446465008334 ABC transporter signature motif; other site 446465008335 Walker B; other site 446465008336 D-loop; other site 446465008337 H-loop/switch region; other site 446465008338 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446465008339 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 446465008340 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008341 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008342 DNA binding site [nucleotide binding] 446465008343 domain linker motif; other site 446465008344 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008345 ligand binding site [chemical binding]; other site 446465008346 dimerization interface [polypeptide binding]; other site 446465008347 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 446465008348 putative active site [active] 446465008349 catalytic site [active] 446465008350 putative metal binding site [ion binding]; other site 446465008351 oligomer interface [polypeptide binding]; other site 446465008352 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 446465008353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008354 dimer interface [polypeptide binding]; other site 446465008355 conserved gate region; other site 446465008356 putative PBP binding loops; other site 446465008357 ABC-ATPase subunit interface; other site 446465008358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008359 dimer interface [polypeptide binding]; other site 446465008360 conserved gate region; other site 446465008361 putative PBP binding loops; other site 446465008362 ABC-ATPase subunit interface; other site 446465008363 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446465008364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465008365 Walker A/P-loop; other site 446465008366 ATP binding site [chemical binding]; other site 446465008367 Q-loop/lid; other site 446465008368 ABC transporter signature motif; other site 446465008369 Walker B; other site 446465008370 D-loop; other site 446465008371 H-loop/switch region; other site 446465008372 TOBE domain; Region: TOBE_2; pfam08402 446465008373 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 446465008374 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 446465008375 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 446465008376 MgtC family; Region: MgtC; pfam02308 446465008377 Divergent AAA domain; Region: AAA_4; pfam04326 446465008378 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 446465008379 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 446465008380 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 446465008381 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 446465008382 dimer interface [polypeptide binding]; other site 446465008383 putative radical transfer pathway; other site 446465008384 diiron center [ion binding]; other site 446465008385 tyrosyl radical; other site 446465008386 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 446465008387 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 446465008388 putative homodimer interface [polypeptide binding]; other site 446465008389 putative homotetramer interface [polypeptide binding]; other site 446465008390 putative allosteric switch controlling residues; other site 446465008391 putative metal binding site [ion binding]; other site 446465008392 putative homodimer-homodimer interface [polypeptide binding]; other site 446465008393 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 446465008394 Rhodanese-like domain; Region: Rhodanese; pfam00581 446465008395 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446465008396 active site residue [active] 446465008397 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446465008398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465008399 Coenzyme A binding pocket [chemical binding]; other site 446465008400 Sulfatase; Region: Sulfatase; cl17466 446465008401 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465008402 L-idonate 5-dehydrogenase; Region: PLN02702 446465008403 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 446465008404 inhibitor binding site; inhibition site 446465008405 catalytic Zn binding site [ion binding]; other site 446465008406 structural Zn binding site [ion binding]; other site 446465008407 NADP binding site [chemical binding]; other site 446465008408 tetramer interface [polypeptide binding]; other site 446465008409 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 446465008410 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 446465008411 trimer interface [polypeptide binding]; other site 446465008412 putative metal binding site [ion binding]; other site 446465008413 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446465008414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465008415 putative substrate translocation pore; other site 446465008416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465008417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465008418 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446465008419 adenosine deaminase; Provisional; Region: PRK09358 446465008420 active site 446465008421 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 446465008422 galactokinase; Provisional; Region: PRK03817 446465008423 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 446465008424 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446465008425 active site 446465008426 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 446465008427 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 446465008428 active site 446465008429 substrate binding site [chemical binding]; other site 446465008430 metal binding site [ion binding]; metal-binding site 446465008431 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465008432 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446465008433 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446465008434 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 446465008435 PRC-barrel domain; Region: PRC; pfam05239 446465008436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465008437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465008438 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 446465008439 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 446465008440 aspartate kinase; Reviewed; Region: PRK06635 446465008441 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 446465008442 putative catalytic residues [active] 446465008443 putative nucleotide binding site [chemical binding]; other site 446465008444 putative aspartate binding site [chemical binding]; other site 446465008445 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 446465008446 putative allosteric regulatory site; other site 446465008447 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 446465008448 putative allosteric regulatory residue; other site 446465008449 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008450 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008451 DNA binding site [nucleotide binding] 446465008452 domain linker motif; other site 446465008453 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008454 dimerization interface [polypeptide binding]; other site 446465008455 ligand binding site [chemical binding]; other site 446465008456 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 446465008457 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 446465008458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465008459 putative substrate translocation pore; other site 446465008460 Predicted amidohydrolase [General function prediction only]; Region: COG0388 446465008461 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 446465008462 multimer interface [polypeptide binding]; other site 446465008463 active site 446465008464 catalytic triad [active] 446465008465 protein interface 1 [polypeptide binding]; other site 446465008466 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 446465008467 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 446465008468 homodimer interface [polypeptide binding]; other site 446465008469 NAD binding pocket [chemical binding]; other site 446465008470 ATP binding pocket [chemical binding]; other site 446465008471 Mg binding site [ion binding]; other site 446465008472 active-site loop [active] 446465008473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008474 dimer interface [polypeptide binding]; other site 446465008475 conserved gate region; other site 446465008476 putative PBP binding loops; other site 446465008477 ABC-ATPase subunit interface; other site 446465008478 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008480 dimer interface [polypeptide binding]; other site 446465008481 conserved gate region; other site 446465008482 putative PBP binding loops; other site 446465008483 ABC-ATPase subunit interface; other site 446465008484 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008485 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465008486 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446465008487 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446465008488 Walker A/P-loop; other site 446465008489 ATP binding site [chemical binding]; other site 446465008490 Q-loop/lid; other site 446465008491 ABC transporter signature motif; other site 446465008492 Walker B; other site 446465008493 D-loop; other site 446465008494 H-loop/switch region; other site 446465008495 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 446465008496 recombination protein RecR; Reviewed; Region: recR; PRK00076 446465008497 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446465008498 RecR protein; Region: RecR; pfam02132 446465008499 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 446465008500 putative active site [active] 446465008501 putative metal-binding site [ion binding]; other site 446465008502 tetramer interface [polypeptide binding]; other site 446465008503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 446465008504 Integrase core domain; Region: rve; pfam00665 446465008505 Integrase core domain; Region: rve_3; pfam13683 446465008506 Uncharacterized conserved protein [Function unknown]; Region: COG3538 446465008507 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 446465008508 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 446465008509 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 446465008510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446465008511 Walker A motif; other site 446465008512 ATP binding site [chemical binding]; other site 446465008513 Walker B motif; other site 446465008514 arginine finger; other site 446465008515 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 446465008516 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 446465008517 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 446465008518 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465008519 hydrophobic ligand binding site; other site 446465008520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465008521 TIGR01777 family protein; Region: yfcH 446465008522 NAD(P) binding site [chemical binding]; other site 446465008523 active site 446465008524 CAAX protease self-immunity; Region: Abi; pfam02517 446465008525 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 446465008526 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 446465008527 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 446465008528 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 446465008529 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 446465008530 Binuclear center (active site) [active] 446465008531 K-pathway; other site 446465008532 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 446465008533 amino acid carrier protein; Region: agcS; TIGR00835 446465008534 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465008535 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465008536 active site 446465008537 catalytic tetrad [active] 446465008538 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 446465008539 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446465008540 NAD(P) binding site [chemical binding]; other site 446465008541 catalytic residues [active] 446465008542 Protein of unknown function (DUF779); Region: DUF779; pfam05610 446465008543 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 446465008544 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 446465008545 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 446465008546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446465008547 galactoside permease; Reviewed; Region: lacY; PRK09528 446465008548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465008549 putative substrate translocation pore; other site 446465008550 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 446465008551 active site 446465008552 hypothetical protein; Provisional; Region: PRK07236 446465008553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465008554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465008555 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 446465008556 Walker A/P-loop; other site 446465008557 ATP binding site [chemical binding]; other site 446465008558 Q-loop/lid; other site 446465008559 ABC transporter signature motif; other site 446465008560 Walker B; other site 446465008561 D-loop; other site 446465008562 H-loop/switch region; other site 446465008563 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446465008564 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446465008565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465008566 Walker A/P-loop; other site 446465008567 ATP binding site [chemical binding]; other site 446465008568 Q-loop/lid; other site 446465008569 ABC transporter signature motif; other site 446465008570 Walker B; other site 446465008571 D-loop; other site 446465008572 H-loop/switch region; other site 446465008573 LrgB-like family; Region: LrgB; cl00596 446465008574 LrgA family; Region: LrgA; cl00608 446465008575 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446465008576 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446465008577 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 446465008578 amidohydrolase; Region: amidohydrolases; TIGR01891 446465008579 metal binding site [ion binding]; metal-binding site 446465008580 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 446465008581 Na2 binding site [ion binding]; other site 446465008582 putative substrate binding site 1 [chemical binding]; other site 446465008583 Na binding site 1 [ion binding]; other site 446465008584 putative substrate binding site 2 [chemical binding]; other site 446465008585 Golgin subfamily A member 7/ERF4 family; Region: Erf4; pfam10256 446465008586 Cobalt transport protein; Region: CbiQ; cl00463 446465008587 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446465008588 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446465008589 Walker A/P-loop; other site 446465008590 ATP binding site [chemical binding]; other site 446465008591 Q-loop/lid; other site 446465008592 ABC transporter signature motif; other site 446465008593 Walker B; other site 446465008594 D-loop; other site 446465008595 H-loop/switch region; other site 446465008596 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446465008597 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446465008598 Walker A/P-loop; other site 446465008599 ATP binding site [chemical binding]; other site 446465008600 Q-loop/lid; other site 446465008601 ABC transporter signature motif; other site 446465008602 Walker B; other site 446465008603 D-loop; other site 446465008604 H-loop/switch region; other site 446465008605 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 446465008606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465008607 motif II; other site 446465008608 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 446465008609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446465008610 motif II; other site 446465008611 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008612 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008613 ligand binding site [chemical binding]; other site 446465008614 dimerization interface [polypeptide binding]; other site 446465008615 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 446465008616 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446465008617 active site 446465008618 nucleotide binding site [chemical binding]; other site 446465008619 HIGH motif; other site 446465008620 KMSKS motif; other site 446465008621 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446465008622 Radical SAM superfamily; Region: Radical_SAM; pfam04055 446465008623 FeS/SAM binding site; other site 446465008624 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446465008625 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446465008626 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 446465008627 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446465008628 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446465008629 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446465008630 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 446465008631 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 446465008632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465008633 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 446465008634 Sulfatase; Region: Sulfatase; pfam00884 446465008635 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465008636 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 446465008637 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446465008638 putative ligand binding site [chemical binding]; other site 446465008639 putative NAD binding site [chemical binding]; other site 446465008640 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008641 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008642 DNA binding site [nucleotide binding] 446465008643 domain linker motif; other site 446465008644 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008645 dimerization interface [polypeptide binding]; other site 446465008646 ligand binding site [chemical binding]; other site 446465008647 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 446465008648 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446465008649 putative ligand binding site [chemical binding]; other site 446465008650 putative NAD binding site [chemical binding]; other site 446465008651 catalytic site [active] 446465008652 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446465008653 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008654 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008655 ligand binding site [chemical binding]; other site 446465008656 dimerization interface [polypeptide binding]; other site 446465008657 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008658 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465008659 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 446465008660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008661 dimer interface [polypeptide binding]; other site 446465008662 conserved gate region; other site 446465008663 putative PBP binding loops; other site 446465008664 ABC-ATPase subunit interface; other site 446465008665 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008667 dimer interface [polypeptide binding]; other site 446465008668 conserved gate region; other site 446465008669 putative PBP binding loops; other site 446465008670 ABC-ATPase subunit interface; other site 446465008671 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 446465008672 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 446465008673 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446465008674 Protein of unknown function (DUF993); Region: DUF993; pfam06187 446465008675 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465008676 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465008677 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 446465008678 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446465008679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446465008680 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465008681 active site 446465008682 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 446465008683 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446465008684 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 446465008685 Abhydrolase family; Region: Abhydrolase_7; pfam12715 446465008686 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008688 dimer interface [polypeptide binding]; other site 446465008689 conserved gate region; other site 446465008690 putative PBP binding loops; other site 446465008691 ABC-ATPase subunit interface; other site 446465008692 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 446465008693 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 446465008694 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008695 Protein of unknown function, DUF624; Region: DUF624; cl02369 446465008696 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465008697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008698 dimer interface [polypeptide binding]; other site 446465008699 conserved gate region; other site 446465008700 ABC-ATPase subunit interface; other site 446465008701 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 446465008702 active site 446465008703 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008704 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008705 DNA binding site [nucleotide binding] 446465008706 domain linker motif; other site 446465008707 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008708 dimerization interface [polypeptide binding]; other site 446465008709 ligand binding site [chemical binding]; other site 446465008710 Methane oxygenase PmoA; Region: PmoA; pfam14100 446465008711 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 446465008712 active site 446465008713 catalytic triad [active] 446465008714 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465008715 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446465008716 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 446465008717 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446465008718 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 446465008719 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 446465008720 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008721 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008722 DNA binding site [nucleotide binding] 446465008723 domain linker motif; other site 446465008724 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008725 dimerization interface [polypeptide binding]; other site 446465008726 ligand binding site [chemical binding]; other site 446465008727 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008728 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465008729 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008731 dimer interface [polypeptide binding]; other site 446465008732 conserved gate region; other site 446465008733 putative PBP binding loops; other site 446465008734 ABC-ATPase subunit interface; other site 446465008735 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008737 dimer interface [polypeptide binding]; other site 446465008738 conserved gate region; other site 446465008739 putative PBP binding loops; other site 446465008740 ABC-ATPase subunit interface; other site 446465008741 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008742 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008743 DNA binding site [nucleotide binding] 446465008744 domain linker motif; other site 446465008745 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008746 dimerization interface [polypeptide binding]; other site 446465008747 ligand binding site [chemical binding]; other site 446465008748 thymidylate synthase; Reviewed; Region: thyA; PRK01827 446465008749 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 446465008750 dimerization interface [polypeptide binding]; other site 446465008751 active site 446465008752 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446465008753 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 446465008754 folate binding site [chemical binding]; other site 446465008755 NADP+ binding site [chemical binding]; other site 446465008756 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 446465008757 substrate binding site [chemical binding]; other site 446465008758 active site 446465008759 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008761 dimer interface [polypeptide binding]; other site 446465008762 conserved gate region; other site 446465008763 putative PBP binding loops; other site 446465008764 ABC-ATPase subunit interface; other site 446465008765 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446465008766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008767 putative PBP binding loops; other site 446465008768 dimer interface [polypeptide binding]; other site 446465008769 ABC-ATPase subunit interface; other site 446465008770 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008771 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008773 dimer interface [polypeptide binding]; other site 446465008774 conserved gate region; other site 446465008775 putative PBP binding loops; other site 446465008776 ABC-ATPase subunit interface; other site 446465008777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008778 dimer interface [polypeptide binding]; other site 446465008779 conserved gate region; other site 446465008780 putative PBP binding loops; other site 446465008781 ABC-ATPase subunit interface; other site 446465008782 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446465008783 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446465008784 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446465008785 TM-ABC transporter signature motif; other site 446465008786 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 446465008787 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446465008788 Walker A/P-loop; other site 446465008789 ATP binding site [chemical binding]; other site 446465008790 Q-loop/lid; other site 446465008791 ABC transporter signature motif; other site 446465008792 Walker B; other site 446465008793 D-loop; other site 446465008794 H-loop/switch region; other site 446465008795 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446465008796 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 446465008797 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 446465008798 putative ligand binding site [chemical binding]; other site 446465008799 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008800 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008801 DNA binding site [nucleotide binding] 446465008802 domain linker motif; other site 446465008803 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446465008804 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 446465008805 putative N- and C-terminal domain interface [polypeptide binding]; other site 446465008806 putative active site [active] 446465008807 MgATP binding site [chemical binding]; other site 446465008808 catalytic site [active] 446465008809 metal binding site [ion binding]; metal-binding site 446465008810 putative carbohydrate binding site [chemical binding]; other site 446465008811 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 446465008812 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 446465008813 intersubunit interface [polypeptide binding]; other site 446465008814 active site 446465008815 Zn2+ binding site [ion binding]; other site 446465008816 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 446465008817 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 446465008818 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 446465008819 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446465008820 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446465008821 dimerization interface [polypeptide binding]; other site 446465008822 L-arabinose isomerase; Provisional; Region: PRK02929 446465008823 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 446465008824 hexamer (dimer of trimers) interface [polypeptide binding]; other site 446465008825 trimer interface [polypeptide binding]; other site 446465008826 substrate binding site [chemical binding]; other site 446465008827 Mn binding site [ion binding]; other site 446465008828 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 446465008829 FAD binding domain; Region: FAD_binding_4; pfam01565 446465008830 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 446465008831 alpha-galactosidase; Region: PLN02808; cl17638 446465008832 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 446465008833 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 446465008834 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446465008835 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446465008836 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 446465008837 Domain of unknown function (DUF718); Region: DUF718; pfam05336 446465008838 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 446465008839 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 446465008840 short chain dehydrogenase; Validated; Region: PRK08324 446465008841 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 446465008842 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 446465008843 putative NAD(P) binding site [chemical binding]; other site 446465008844 active site 446465008845 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 446465008846 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 446465008847 N- and C-terminal domain interface [polypeptide binding]; other site 446465008848 active site 446465008849 putative catalytic site [active] 446465008850 metal binding site [ion binding]; metal-binding site 446465008851 ATP binding site [chemical binding]; other site 446465008852 carbohydrate binding site [chemical binding]; other site 446465008853 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465008854 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465008855 DNA binding site [nucleotide binding] 446465008856 domain linker motif; other site 446465008857 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465008858 dimerization interface [polypeptide binding]; other site 446465008859 ligand binding site [chemical binding]; other site 446465008860 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 446465008861 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 446465008862 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465008863 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465008864 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465008865 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465008866 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465008867 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008869 dimer interface [polypeptide binding]; other site 446465008870 conserved gate region; other site 446465008871 putative PBP binding loops; other site 446465008872 ABC-ATPase subunit interface; other site 446465008873 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465008874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008875 dimer interface [polypeptide binding]; other site 446465008876 putative PBP binding loops; other site 446465008877 ABC-ATPase subunit interface; other site 446465008878 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008879 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465008880 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008881 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446465008882 NAD-dependent deacetylase; Provisional; Region: PRK00481 446465008883 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 446465008884 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 446465008885 putative active site [active] 446465008886 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 446465008887 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 446465008888 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 446465008889 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 446465008890 benzoate transport; Region: 2A0115; TIGR00895 446465008891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465008892 putative substrate translocation pore; other site 446465008893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465008894 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 446465008895 dihydroxyacetone kinase; Provisional; Region: PRK14479 446465008896 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 446465008897 DAK2 domain; Region: Dak2; pfam02734 446465008898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465008899 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446465008900 NAD(P) binding site [chemical binding]; other site 446465008901 active site 446465008902 polyol permease family; Region: 2A0118; TIGR00897 446465008903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465008904 putative substrate translocation pore; other site 446465008905 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446465008906 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446465008907 NAD(P) binding site [chemical binding]; other site 446465008908 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 446465008909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465008910 sequence-specific DNA binding site [nucleotide binding]; other site 446465008911 salt bridge; other site 446465008912 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 446465008913 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 446465008914 N- and C-terminal domain interface [polypeptide binding]; other site 446465008915 D-xylulose kinase; Region: XylB; TIGR01312 446465008916 putative active site [active] 446465008917 MgATP binding site [chemical binding]; other site 446465008918 catalytic site [active] 446465008919 metal binding site [ion binding]; metal-binding site 446465008920 putative xylulose binding site [chemical binding]; other site 446465008921 putative homodimer interface [polypeptide binding]; other site 446465008922 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465008923 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446465008924 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465008925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008926 dimer interface [polypeptide binding]; other site 446465008927 conserved gate region; other site 446465008928 putative PBP binding loops; other site 446465008929 ABC-ATPase subunit interface; other site 446465008930 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 446465008931 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 446465008932 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 446465008933 Na binding site [ion binding]; other site 446465008934 glycerol kinase; Provisional; Region: glpK; PRK00047 446465008935 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 446465008936 N- and C-terminal domain interface [polypeptide binding]; other site 446465008937 active site 446465008938 MgATP binding site [chemical binding]; other site 446465008939 catalytic site [active] 446465008940 metal binding site [ion binding]; metal-binding site 446465008941 putative homotetramer interface [polypeptide binding]; other site 446465008942 glycerol binding site [chemical binding]; other site 446465008943 homodimer interface [polypeptide binding]; other site 446465008944 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 446465008945 amphipathic channel; other site 446465008946 Asn-Pro-Ala signature motifs; other site 446465008947 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 446465008948 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 446465008949 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 446465008950 DNA binding residues [nucleotide binding] 446465008951 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 446465008952 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 446465008953 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465008954 hydrophobic ligand binding site; other site 446465008955 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 446465008956 putative hydrophobic ligand binding site [chemical binding]; other site 446465008957 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446465008958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446465008959 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446465008960 dimerization interface [polypeptide binding]; other site 446465008961 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446465008962 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 446465008963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008964 putative PBP binding loops; other site 446465008965 ABC-ATPase subunit interface; other site 446465008966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446465008967 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446465008968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465008969 Walker A/P-loop; other site 446465008970 ATP binding site [chemical binding]; other site 446465008971 Q-loop/lid; other site 446465008972 ABC transporter signature motif; other site 446465008973 Walker B; other site 446465008974 D-loop; other site 446465008975 H-loop/switch region; other site 446465008976 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 446465008977 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 446465008978 active site 446465008979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008980 dimer interface [polypeptide binding]; other site 446465008981 conserved gate region; other site 446465008982 putative PBP binding loops; other site 446465008983 ABC-ATPase subunit interface; other site 446465008984 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446465008985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465008986 dimer interface [polypeptide binding]; other site 446465008987 conserved gate region; other site 446465008988 putative PBP binding loops; other site 446465008989 ABC-ATPase subunit interface; other site 446465008990 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 446465008991 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446465008992 substrate binding pocket [chemical binding]; other site 446465008993 membrane-bound complex binding site; other site 446465008994 hinge residues; other site 446465008995 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446465008996 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446465008997 Walker A/P-loop; other site 446465008998 ATP binding site [chemical binding]; other site 446465008999 Q-loop/lid; other site 446465009000 ABC transporter signature motif; other site 446465009001 Walker B; other site 446465009002 D-loop; other site 446465009003 H-loop/switch region; other site 446465009004 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 446465009005 dimer interface [polypeptide binding]; other site 446465009006 substrate binding site [chemical binding]; other site 446465009007 ATP binding site [chemical binding]; other site 446465009008 GtrA-like protein; Region: GtrA; pfam04138 446465009009 Predicted membrane protein [Function unknown]; Region: COG2246 446465009010 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 446465009011 putative ADP-ribose binding site [chemical binding]; other site 446465009012 putative active site [active] 446465009013 aminotransferase; Validated; Region: PRK07777 446465009014 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446465009015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465009016 homodimer interface [polypeptide binding]; other site 446465009017 catalytic residue [active] 446465009018 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446465009019 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446465009020 substrate binding site [chemical binding]; other site 446465009021 oxyanion hole (OAH) forming residues; other site 446465009022 trimer interface [polypeptide binding]; other site 446465009023 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 446465009024 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446465009025 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446465009026 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 446465009027 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465009028 hydrophobic ligand binding site; other site 446465009029 Predicted acetyltransferase [General function prediction only]; Region: COG3393 446465009030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465009031 Coenzyme A binding pocket [chemical binding]; other site 446465009032 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446465009033 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446465009034 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446465009035 catalytic residue [active] 446465009036 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 446465009037 Peptidase M66; Region: Peptidase_M66; pfam10462 446465009038 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446465009039 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446465009040 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446465009041 active site 446465009042 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 446465009043 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446465009044 dimer interface [polypeptide binding]; other site 446465009045 active site 446465009046 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446465009047 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446465009048 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 446465009049 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 446465009050 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446465009051 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 446465009052 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 446465009053 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446465009054 active site 446465009055 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 446465009056 catalytic triad [active] 446465009057 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446465009058 Beta-lactamase; Region: Beta-lactamase; pfam00144 446465009059 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 446465009060 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446465009061 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465009062 active site 446465009063 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 446465009064 catalytic residues [active] 446465009065 dimer interface [polypeptide binding]; other site 446465009066 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446465009067 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446465009068 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 446465009069 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 446465009070 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 446465009071 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446465009072 Ligand Binding Site [chemical binding]; other site 446465009073 amino acid transporter; Region: 2A0306; TIGR00909 446465009074 LssY C-terminus; Region: LssY_C; pfam14067 446465009075 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446465009076 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465009077 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465009078 active site 446465009079 catalytic tetrad [active] 446465009080 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 446465009081 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446465009082 Walker A/P-loop; other site 446465009083 ATP binding site [chemical binding]; other site 446465009084 Q-loop/lid; other site 446465009085 ABC transporter signature motif; other site 446465009086 Walker B; other site 446465009087 D-loop; other site 446465009088 H-loop/switch region; other site 446465009089 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446465009090 ABC-ATPase subunit interface; other site 446465009091 dimer interface [polypeptide binding]; other site 446465009092 putative PBP binding regions; other site 446465009093 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446465009094 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446465009095 ABC-ATPase subunit interface; other site 446465009096 dimer interface [polypeptide binding]; other site 446465009097 putative PBP binding regions; other site 446465009098 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446465009099 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446465009100 intersubunit interface [polypeptide binding]; other site 446465009101 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 446465009102 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 446465009103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465009104 S-adenosylmethionine binding site [chemical binding]; other site 446465009105 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 446465009106 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 446465009107 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 446465009108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465009109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465009110 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 446465009111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446465009112 Walker A/P-loop; other site 446465009113 ATP binding site [chemical binding]; other site 446465009114 Q-loop/lid; other site 446465009115 ABC transporter signature motif; other site 446465009116 Walker B; other site 446465009117 D-loop; other site 446465009118 H-loop/switch region; other site 446465009119 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446465009120 Isochorismatase family; Region: Isochorismatase; pfam00857 446465009121 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 446465009122 catalytic triad [active] 446465009123 conserved cis-peptide bond; other site 446465009124 Protein of unknown function, DUF488; Region: DUF488; pfam04343 446465009125 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 446465009126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446465009127 NAD(P) binding site [chemical binding]; other site 446465009128 active site 446465009129 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 446465009130 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 446465009131 active site 446465009132 Zn binding site [ion binding]; other site 446465009133 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 446465009134 active sites [active] 446465009135 tetramer interface [polypeptide binding]; other site 446465009136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 446465009137 Nucleoside recognition; Region: Gate; pfam07670 446465009138 imidazolonepropionase; Provisional; Region: PRK14085 446465009139 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446465009140 active site 446465009141 urocanate hydratase; Provisional; Region: PRK05414 446465009142 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446465009143 Bacterial transcriptional regulator; Region: IclR; pfam01614 446465009144 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 446465009145 active site 446465009146 metal binding site [ion binding]; metal-binding site 446465009147 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446465009148 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446465009149 substrate binding site [chemical binding]; other site 446465009150 Fructosamine kinase; Region: Fructosamin_kin; cl17579 446465009151 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 446465009152 glutamate dehydrogenase; Provisional; Region: PRK09414 446465009153 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 446465009154 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 446465009155 NAD(P) binding site [chemical binding]; other site 446465009156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465009157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446465009158 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446465009159 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446465009160 active site 446465009161 catalytic site [active] 446465009162 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446465009163 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446465009164 active site 446465009165 catalytic site [active] 446465009166 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446465009167 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446465009168 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446465009169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465009170 dimer interface [polypeptide binding]; other site 446465009171 conserved gate region; other site 446465009172 putative PBP binding loops; other site 446465009173 ABC-ATPase subunit interface; other site 446465009174 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446465009175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446465009176 dimer interface [polypeptide binding]; other site 446465009177 conserved gate region; other site 446465009178 putative PBP binding loops; other site 446465009179 ABC-ATPase subunit interface; other site 446465009180 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465009181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465009182 DNA binding site [nucleotide binding] 446465009183 domain linker motif; other site 446465009184 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465009185 ligand binding site [chemical binding]; other site 446465009186 dimerization interface [polypeptide binding]; other site 446465009187 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 446465009188 Ferritin-like domain; Region: Ferritin; pfam00210 446465009189 ferroxidase diiron center [ion binding]; other site 446465009190 BCCT family transporter; Region: BCCT; pfam02028 446465009191 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446465009192 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446465009193 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446465009194 tetracycline repressor protein TetR; Provisional; Region: PRK13756 446465009195 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465009196 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446465009197 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446465009198 putative catalytic site [active] 446465009199 putative metal binding site [ion binding]; other site 446465009200 putative phosphate binding site [ion binding]; other site 446465009201 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 446465009202 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 446465009203 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 446465009204 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 446465009205 protein binding site [polypeptide binding]; other site 446465009206 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 446465009207 Domain interface; other site 446465009208 Peptide binding site; other site 446465009209 Active site tetrad [active] 446465009210 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446465009211 hydrophobic ligand binding site; other site 446465009212 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446465009213 Ligand Binding Site [chemical binding]; other site 446465009214 Protein of unknown function (DUF461); Region: DUF461; pfam04314 446465009215 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 446465009216 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 446465009217 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 446465009218 N- and C-terminal domain interface [polypeptide binding]; other site 446465009219 active site 446465009220 catalytic site [active] 446465009221 metal binding site [ion binding]; metal-binding site 446465009222 carbohydrate binding site [chemical binding]; other site 446465009223 ATP binding site [chemical binding]; other site 446465009224 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 446465009225 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 446465009226 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 446465009227 glucuronate isomerase; Reviewed; Region: PRK02925 446465009228 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 446465009229 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446465009230 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446465009231 DNA binding site [nucleotide binding] 446465009232 domain linker motif; other site 446465009233 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446465009234 ligand binding site [chemical binding]; other site 446465009235 dimerization interface [polypeptide binding]; other site 446465009236 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 446465009237 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 446465009238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446465009239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446465009240 AIR carboxylase; Region: AIRC; smart01001 446465009241 TIGR00268 family protein; Region: TIGR00268 446465009242 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 446465009243 Ligand Binding Site [chemical binding]; other site 446465009244 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 446465009245 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446465009246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465009247 S-adenosylmethionine binding site [chemical binding]; other site 446465009248 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446465009249 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 446465009250 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446465009251 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446465009252 active site 446465009253 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 446465009254 arsenical-resistance protein; Region: acr3; TIGR00832 446465009255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446465009256 dimerization interface [polypeptide binding]; other site 446465009257 putative DNA binding site [nucleotide binding]; other site 446465009258 putative Zn2+ binding site [ion binding]; other site 446465009259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446465009260 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446465009261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446465009262 Coenzyme A binding pocket [chemical binding]; other site 446465009263 cyanate transporter; Region: CynX; TIGR00896 446465009264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446465009265 putative substrate translocation pore; other site 446465009266 Cupin domain; Region: Cupin_2; cl17218 446465009267 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 446465009268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446465009269 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446465009270 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446465009271 active site 446465009272 catalytic tetrad [active] 446465009273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446465009274 salt bridge; other site 446465009275 non-specific DNA binding site [nucleotide binding]; other site 446465009276 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446465009277 sequence-specific DNA binding site [nucleotide binding]; other site 446465009278 sugar efflux transporter B; Provisional; Region: PRK15011 446465009279 short chain dehydrogenase; Provisional; Region: PRK06523 446465009280 classical (c) SDRs; Region: SDR_c; cd05233 446465009281 NAD(P) binding site [chemical binding]; other site 446465009282 active site 446465009283 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446465009284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446465009285 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 446465009286 putative acyltransferase; Provisional; Region: PRK05790 446465009287 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446465009288 dimer interface [polypeptide binding]; other site 446465009289 active site 446465009290 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 446465009291 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 446465009292 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 446465009293 FeoA domain; Region: FeoA; pfam04023 446465009294 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 446465009295 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446465009296 dimer interface [polypeptide binding]; other site 446465009297 putative PBP binding regions; other site 446465009298 ABC-ATPase subunit interface; other site 446465009299 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446465009300 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 446465009301 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 446465009302 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 446465009303 metal binding site [ion binding]; metal-binding site 446465009304 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446465009305 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465009306 DNA-binding site [nucleotide binding]; DNA binding site 446465009307 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446465009308 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 446465009309 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 446465009310 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446465009311 Soluble P-type ATPase [General function prediction only]; Region: COG4087 446465009312 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446465009313 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446465009314 dimer interface [polypeptide binding]; other site 446465009315 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 446465009316 active site clefts [active] 446465009317 zinc binding site [ion binding]; other site 446465009318 dimer interface [polypeptide binding]; other site 446465009319 aminodeoxychorismate synthase; Provisional; Region: PRK07508 446465009320 chorismate binding enzyme; Region: Chorismate_bind; cl10555 446465009321 homodimer interface [polypeptide binding]; other site 446465009322 substrate-cofactor binding pocket; other site 446465009323 Aminotransferase class IV; Region: Aminotran_4; pfam01063 446465009324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446465009325 catalytic residue [active] 446465009326 hypothetical protein; Provisional; Region: PRK04194 446465009327 Cupin domain; Region: Cupin_2; cl17218 446465009328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446465009329 S-adenosylmethionine binding site [chemical binding]; other site 446465009330 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 446465009331 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446465009332 Domain of unknown function DUF21; Region: DUF21; pfam01595 446465009333 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446465009334 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446465009335 Domain of unknown function DUF21; Region: DUF21; pfam01595 446465009336 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446465009337 Transporter associated domain; Region: CorC_HlyC; pfam03471 446465009338 Predicted esterase [General function prediction only]; Region: COG0400 446465009339 Serine hydrolase (FSH1); Region: FSH1; pfam03959 446465009340 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 446465009341 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 446465009342 intracellular protease, PfpI family; Region: PfpI; TIGR01382 446465009343 proposed catalytic triad [active] 446465009344 conserved cys residue [active] 446465009345 hypothetical protein; Validated; Region: PRK00029 446465009346 Uncharacterized conserved protein [Function unknown]; Region: COG0397 446465009347 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 446465009348 Proline racemase; Region: Pro_racemase; pfam05544 446465009349 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446465009350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446465009351 DNA-binding site [nucleotide binding]; DNA binding site 446465009352 FCD domain; Region: FCD; pfam07729 446465009353 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446465009354 hydroxyglutarate oxidase; Provisional; Region: PRK11728 446465009355 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 446465009356 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446465009357 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446465009358 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446465009359 NAD(P) binding site [chemical binding]; other site 446465009360 catalytic residues [active] 446465009361 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446465009362 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 446465009363 inhibitor site; inhibition site 446465009364 active site 446465009365 dimer interface [polypeptide binding]; other site 446465009366 catalytic residue [active] 446465009367 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 446465009368 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446465009369 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446465009370 nucleotide binding site [chemical binding]; other site 446465009371 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446465009372 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446465009373 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446465009374 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446465009375 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446465009376 active site 446465009377 LabA_like proteins; Region: LabA_like; cd06167 446465009378 putative metal binding site [ion binding]; other site 446465009379 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446465009380 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446465009381 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446465009382 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 446465009383 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 446465009384 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 446465009385 L11 interface [polypeptide binding]; other site 446465009386 putative EF-Tu interaction site [polypeptide binding]; other site 446465009387 putative EF-G interaction site [polypeptide binding]; other site 446465009388 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 446465009389 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 446465009390 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 446465009391 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 446465009392 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 446465009393 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446465009394 dimer interface [polypeptide binding]; other site 446465009395 ssDNA binding site [nucleotide binding]; other site 446465009396 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446465009397 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 446465009398 amino acid transporter; Region: 2A0306; TIGR00909 446465009399 hydroperoxidase II; Provisional; Region: katE; PRK11249 446465009400 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 446465009401 heme binding pocket [chemical binding]; other site 446465009402 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 446465009403 domain interactions; other site 446465009404 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 446465009405 Transglycosylase; Region: Transgly; pfam00912 446465009406 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446465009407 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 446465009408 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 446465009409 active site 446465009410 NTP binding site [chemical binding]; other site 446465009411 metal binding triad [ion binding]; metal-binding site 446465009412 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 446465009413 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446465009414 Zn2+ binding site [ion binding]; other site 446465009415 Mg2+ binding site [ion binding]; other site 446465009416 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 446465009417 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 446465009418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446465009419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446465009420 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 446465009421 ParB-like nuclease domain; Region: ParBc; pfam02195 446465009422 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446465009423 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446465009424 P-loop; other site 446465009425 Magnesium ion binding site [ion binding]; other site 446465009426 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446465009427 Magnesium ion binding site [ion binding]; other site 446465009428 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 446465009429 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 446465009430 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 446465009431 G-X-X-G motif; other site 446465009432 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 446465009433 RxxxH motif; other site 446465009434 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 446465009435 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 446465009436 Haemolytic domain; Region: Haemolytic; pfam01809 446465009437 Ribonuclease P; Region: Ribonuclease_P; pfam00825 446465009438 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399