-- dump date 20140619_005026 -- class Genbank::misc_feature -- table misc_feature_note -- id note 565034000001 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 565034000002 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 565034000003 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 565034000004 substrate binding site [chemical binding]; other site 565034000005 hexamer interface [polypeptide binding]; other site 565034000006 metal binding site [ion binding]; metal-binding site 565034000007 rarD protein; Region: rarD; TIGR00688 565034000008 TPR repeat; Region: TPR_11; pfam13414 565034000009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034000010 binding surface 565034000011 TPR motif; other site 565034000012 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 565034000013 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 565034000014 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 565034000015 pyruvate kinase; Provisional; Region: PRK05826 565034000016 domain interfaces; other site 565034000017 active site 565034000018 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 565034000019 Na2 binding site [ion binding]; other site 565034000020 putative substrate binding site 1 [chemical binding]; other site 565034000021 Na binding site 1 [ion binding]; other site 565034000022 putative substrate binding site 2 [chemical binding]; other site 565034000023 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 565034000024 CoenzymeA binding site [chemical binding]; other site 565034000025 subunit interaction site [polypeptide binding]; other site 565034000026 PHB binding site; other site 565034000027 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 565034000028 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 565034000029 Global regulator protein family; Region: CsrA; pfam02599 565034000030 FliW protein; Region: FliW; cl00740 565034000031 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 565034000032 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 565034000033 Methyltransferase domain; Region: Methyltransf_31; pfam13847 565034000034 Methyltransferase domain; Region: Methyltransf_24; pfam13578 565034000035 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 565034000036 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 565034000037 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 565034000038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034000039 active site 565034000040 hypothetical protein; Provisional; Region: PRK10621 565034000041 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 565034000042 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 565034000043 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 565034000044 inhibitor-cofactor binding pocket; inhibition site 565034000045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034000046 catalytic residue [active] 565034000047 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034000048 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034000049 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 565034000050 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 565034000051 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 565034000052 Winged helix-turn helix; Region: HTH_29; pfam13551 565034000053 Homeodomain-like domain; Region: HTH_23; pfam13384 565034000054 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 565034000055 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 565034000056 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 565034000057 intersubunit interface [polypeptide binding]; other site 565034000058 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 565034000059 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 565034000060 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 565034000061 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 565034000062 ABC-ATPase subunit interface; other site 565034000063 dimer interface [polypeptide binding]; other site 565034000064 putative PBP binding regions; other site 565034000065 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 565034000066 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 565034000067 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 565034000068 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 565034000069 active site 565034000070 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 565034000071 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 565034000072 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 565034000073 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 565034000074 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 565034000075 TPP-binding site; other site 565034000076 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 565034000077 PYR/PP interface [polypeptide binding]; other site 565034000078 dimer interface [polypeptide binding]; other site 565034000079 TPP binding site [chemical binding]; other site 565034000080 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 565034000081 Transglycosylase; Region: Transgly; pfam00912 565034000082 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 565034000083 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 565034000084 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034000085 dimerization interface [polypeptide binding]; other site 565034000086 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034000087 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034000088 dimer interface [polypeptide binding]; other site 565034000089 putative CheW interface [polypeptide binding]; other site 565034000090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034000091 dimerization interface [polypeptide binding]; other site 565034000092 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034000093 dimer interface [polypeptide binding]; other site 565034000094 putative CheW interface [polypeptide binding]; other site 565034000095 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 565034000096 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 565034000097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034000098 FeS/SAM binding site; other site 565034000099 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 565034000100 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 565034000101 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 565034000102 G1 box; other site 565034000103 GTP/Mg2+ binding site [chemical binding]; other site 565034000104 Switch I region; other site 565034000105 G2 box; other site 565034000106 Switch II region; other site 565034000107 G3 box; other site 565034000108 G4 box; other site 565034000109 G5 box; other site 565034000110 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 565034000111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034000112 FeS/SAM binding site; other site 565034000113 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 565034000114 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 565034000115 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 565034000116 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 565034000117 Ligand binding site; other site 565034000118 metal-binding site 565034000119 xanthine permease; Region: pbuX; TIGR03173 565034000120 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 565034000121 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 565034000122 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 565034000123 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 565034000124 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 565034000125 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 565034000126 carbamate kinase; Reviewed; Region: PRK12686 565034000127 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 565034000128 putative substrate binding site [chemical binding]; other site 565034000129 nucleotide binding site [chemical binding]; other site 565034000130 nucleotide binding site [chemical binding]; other site 565034000131 homodimer interface [polypeptide binding]; other site 565034000132 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 565034000133 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 565034000134 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 565034000135 peptidase; Reviewed; Region: PRK13004 565034000136 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 565034000137 putative metal binding site [ion binding]; other site 565034000138 putative dimer interface [polypeptide binding]; other site 565034000139 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 565034000140 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 565034000141 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 565034000142 catalytic residue [active] 565034000143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 565034000144 YheO-like PAS domain; Region: PAS_6; pfam08348 565034000145 HTH domain; Region: HTH_22; pfam13309 565034000146 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 565034000147 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 565034000148 active site 565034000149 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 565034000150 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565034000151 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 565034000152 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 565034000153 catalytic loop [active] 565034000154 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 565034000155 iron binding site [ion binding]; other site 565034000156 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 565034000157 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 565034000158 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 565034000159 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 565034000160 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 565034000161 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000162 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000163 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000164 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000165 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000166 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000167 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000168 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034000169 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000170 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000171 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000172 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000173 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000174 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034000175 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034000176 phenylhydantoinase; Validated; Region: PRK08323 565034000177 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 565034000178 tetramer interface [polypeptide binding]; other site 565034000179 active site 565034000180 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565034000181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565034000182 DNA binding site [nucleotide binding] 565034000183 domain linker motif; other site 565034000184 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 565034000185 dimerization interface [polypeptide binding]; other site 565034000186 ligand binding site [chemical binding]; other site 565034000187 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 565034000188 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565034000189 active site turn [active] 565034000190 phosphorylation site [posttranslational modification] 565034000191 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565034000192 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 565034000193 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 565034000194 substrate binding [chemical binding]; other site 565034000195 active site 565034000196 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 565034000197 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 565034000198 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 565034000199 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 565034000200 glycogen synthase; Provisional; Region: glgA; PRK00654 565034000201 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 565034000202 ADP-binding pocket [chemical binding]; other site 565034000203 homodimer interface [polypeptide binding]; other site 565034000204 intracellular protease, PfpI family; Region: PfpI; TIGR01382 565034000205 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 565034000206 conserved cys residue [active] 565034000207 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 565034000208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034000209 active site 565034000210 motif I; other site 565034000211 motif II; other site 565034000212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034000213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034000214 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565034000215 active site 565034000216 motif I; other site 565034000217 motif II; other site 565034000218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034000219 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 565034000220 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 565034000221 ligand binding site; other site 565034000222 oligomer interface; other site 565034000223 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034000224 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 565034000225 dimer interface [polypeptide binding]; other site 565034000226 N-terminal domain interface [polypeptide binding]; other site 565034000227 sulfate 1 binding site; other site 565034000228 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034000229 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 565034000230 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 565034000231 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 565034000232 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 565034000233 Coenzyme A binding pocket [chemical binding]; other site 565034000234 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 565034000235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565034000236 Coenzyme A binding pocket [chemical binding]; other site 565034000237 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 565034000238 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 565034000239 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034000240 active site 565034000241 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 565034000242 GIY-YIG motif/motif A; other site 565034000243 putative active site [active] 565034000244 putative metal binding site [ion binding]; other site 565034000245 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 565034000246 transketolase; Reviewed; Region: PRK05899 565034000247 TPP-binding site [chemical binding]; other site 565034000248 dimer interface [polypeptide binding]; other site 565034000249 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 565034000250 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 565034000251 PYR/PP interface [polypeptide binding]; other site 565034000252 dimer interface [polypeptide binding]; other site 565034000253 TPP binding site [chemical binding]; other site 565034000254 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 565034000255 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 565034000256 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 565034000257 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 565034000258 MraW methylase family; Region: Methyltransf_5; cl17771 565034000259 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 565034000260 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 565034000261 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 565034000262 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 565034000263 Hpr binding site; other site 565034000264 active site 565034000265 homohexamer subunit interaction site [polypeptide binding]; other site 565034000266 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565034000267 active site 565034000268 phosphorylation site [posttranslational modification] 565034000269 Sigma 54 modulation protein / S30EA ribosomal protein; Region: Ribosomal_S30AE; pfam02482 565034000270 30S subunit binding site; other site 565034000271 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 565034000272 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 565034000273 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 565034000274 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 565034000275 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 565034000276 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034000277 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000278 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000279 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000280 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 565034000281 Fe-S cluster binding site [ion binding]; other site 565034000282 active site 565034000283 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034000284 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034000285 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000286 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000287 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000288 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034000289 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000290 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000291 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000292 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000293 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000294 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034000295 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034000296 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 565034000297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565034000298 ATP binding site [chemical binding]; other site 565034000299 Mg2+ binding site [ion binding]; other site 565034000300 G-X-G motif; other site 565034000301 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 565034000302 ATP binding site [chemical binding]; other site 565034000303 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 565034000304 putative acyltransferase; Provisional; Region: PRK05790 565034000305 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 565034000306 dimer interface [polypeptide binding]; other site 565034000307 active site 565034000308 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 565034000309 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 565034000310 substrate binding site [chemical binding]; other site 565034000311 oxyanion hole (OAH) forming residues; other site 565034000312 trimer interface [polypeptide binding]; other site 565034000313 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 565034000314 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 565034000315 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 565034000316 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 565034000317 heme-binding site [chemical binding]; other site 565034000318 transcriptional regulator SlyA; Provisional; Region: PRK03573 565034000319 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 565034000320 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034000321 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000322 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000323 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000324 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000325 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000326 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000327 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000328 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 565034000329 Protein of unknown function DUF58; Region: DUF58; pfam01882 565034000330 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 565034000331 metal ion-dependent adhesion site (MIDAS); other site 565034000332 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034000333 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 565034000334 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034000335 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034000336 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 565034000337 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 565034000338 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 565034000339 dimer interface [polypeptide binding]; other site 565034000340 motif 1; other site 565034000341 active site 565034000342 motif 2; other site 565034000343 motif 3; other site 565034000344 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 565034000345 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 565034000346 putative tRNA-binding site [nucleotide binding]; other site 565034000347 B3/4 domain; Region: B3_4; pfam03483 565034000348 tRNA synthetase B5 domain; Region: B5; pfam03484 565034000349 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 565034000350 dimer interface [polypeptide binding]; other site 565034000351 motif 1; other site 565034000352 motif 3; other site 565034000353 motif 2; other site 565034000354 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 565034000355 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565034000356 active site 565034000357 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 565034000358 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 565034000359 GIY-YIG motif/motif A; other site 565034000360 active site 565034000361 catalytic site [active] 565034000362 putative DNA binding site [nucleotide binding]; other site 565034000363 metal binding site [ion binding]; metal-binding site 565034000364 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 565034000365 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 565034000366 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 565034000367 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034000368 Helix-turn-helix domain; Region: HTH_36; pfam13730 565034000369 Methyltransferase domain; Region: Methyltransf_31; pfam13847 565034000370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034000371 S-adenosylmethionine binding site [chemical binding]; other site 565034000372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 565034000373 Nucleoside recognition; Region: Gate; pfam07670 565034000374 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 565034000375 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 565034000376 substrate binding site [chemical binding]; other site 565034000377 multimerization interface [polypeptide binding]; other site 565034000378 ATP binding site [chemical binding]; other site 565034000379 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 565034000380 Sodium Bile acid symporter family; Region: SBF; pfam01758 565034000381 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 565034000382 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 565034000383 putative active site [active] 565034000384 metal binding site [ion binding]; metal-binding site 565034000385 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 565034000386 Cache domain; Region: Cache_1; pfam02743 565034000387 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034000388 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034000389 dimer interface [polypeptide binding]; other site 565034000390 putative CheW interface [polypeptide binding]; other site 565034000391 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 565034000392 Ferritin-like domain; Region: Ferritin; pfam00210 565034000393 ferroxidase diiron center [ion binding]; other site 565034000394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034000395 binding surface 565034000396 TPR motif; other site 565034000397 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 565034000398 glutamate dehydrogenase; Provisional; Region: PRK09414 565034000399 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 565034000400 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 565034000401 NAD(P) binding site [chemical binding]; other site 565034000402 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 565034000403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565034000404 Coenzyme A binding pocket [chemical binding]; other site 565034000405 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 565034000406 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 565034000407 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 565034000408 PhoU domain; Region: PhoU; pfam01895 565034000409 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 565034000410 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 565034000411 NADP binding site [chemical binding]; other site 565034000412 active site 565034000413 putative substrate binding site [chemical binding]; other site 565034000414 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 565034000415 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 565034000416 NADP-binding site; other site 565034000417 homotetramer interface [polypeptide binding]; other site 565034000418 substrate binding site [chemical binding]; other site 565034000419 homodimer interface [polypeptide binding]; other site 565034000420 active site 565034000421 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 565034000422 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 565034000423 N-acetyl-D-glucosamine binding site [chemical binding]; other site 565034000424 catalytic residue [active] 565034000425 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565034000426 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565034000427 Predicted transcriptional regulator [Transcription]; Region: COG1959 565034000428 Transcriptional regulator; Region: Rrf2; pfam02082 565034000429 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 565034000430 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 565034000431 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 565034000432 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 565034000433 metal binding site [ion binding]; metal-binding site 565034000434 dimer interface [polypeptide binding]; other site 565034000435 RelB antitoxin; Region: RelB; cl01171 565034000436 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 565034000437 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 565034000438 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565034000439 active site 565034000440 HIGH motif; other site 565034000441 nucleotide binding site [chemical binding]; other site 565034000442 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 565034000443 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 565034000444 active site 565034000445 KMSKS motif; other site 565034000446 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 565034000447 tRNA binding surface [nucleotide binding]; other site 565034000448 anticodon binding site; other site 565034000449 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 565034000450 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 565034000451 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 565034000452 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 565034000453 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 565034000454 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 565034000455 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 565034000456 Competence protein; Region: Competence; pfam03772 565034000457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565034000458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565034000459 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 565034000460 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 565034000461 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 565034000462 ring oligomerisation interface [polypeptide binding]; other site 565034000463 ATP/Mg binding site [chemical binding]; other site 565034000464 stacking interactions; other site 565034000465 hinge regions; other site 565034000466 Cache domain; Region: Cache_1; pfam02743 565034000467 HAMP domain; Region: HAMP; pfam00672 565034000468 dimerization interface [polypeptide binding]; other site 565034000469 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034000470 dimer interface [polypeptide binding]; other site 565034000471 putative CheW interface [polypeptide binding]; other site 565034000472 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 565034000473 Rrf2 family protein; Region: rrf2_super; TIGR00738 565034000474 thymidylate synthase; Reviewed; Region: thyA; PRK01827 565034000475 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 565034000476 dimerization interface [polypeptide binding]; other site 565034000477 active site 565034000478 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 565034000479 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 565034000480 folate binding site [chemical binding]; other site 565034000481 NADP+ binding site [chemical binding]; other site 565034000482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034000483 binding surface 565034000484 TPR motif; other site 565034000485 TPR repeat; Region: TPR_11; pfam13414 565034000486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034000487 binding surface 565034000488 TPR motif; other site 565034000489 TPR repeat; Region: TPR_11; pfam13414 565034000490 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034000491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034000492 binding surface 565034000493 TPR motif; other site 565034000494 TPR repeat; Region: TPR_11; pfam13414 565034000495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034000496 binding surface 565034000497 TPR motif; other site 565034000498 TPR repeat; Region: TPR_11; pfam13414 565034000499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034000500 TPR repeat; Region: TPR_11; pfam13414 565034000501 binding surface 565034000502 TPR motif; other site 565034000503 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 565034000504 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 565034000505 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565034000506 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565034000507 Walker A/P-loop; other site 565034000508 ATP binding site [chemical binding]; other site 565034000509 Q-loop/lid; other site 565034000510 ABC transporter signature motif; other site 565034000511 Walker B; other site 565034000512 D-loop; other site 565034000513 H-loop/switch region; other site 565034000514 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565034000515 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565034000516 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 565034000517 Walker A/P-loop; other site 565034000518 ATP binding site [chemical binding]; other site 565034000519 Q-loop/lid; other site 565034000520 ABC transporter signature motif; other site 565034000521 Walker B; other site 565034000522 D-loop; other site 565034000523 H-loop/switch region; other site 565034000524 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 565034000525 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 565034000526 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 565034000527 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 565034000528 propionate/acetate kinase; Provisional; Region: PRK12379 565034000529 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034000530 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034000531 peptide binding site [polypeptide binding]; other site 565034000532 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 565034000533 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 565034000534 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 565034000535 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 565034000536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565034000537 Coenzyme A binding pocket [chemical binding]; other site 565034000538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565034000539 Coenzyme A binding pocket [chemical binding]; other site 565034000540 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 565034000541 putative nucleotide binding site [chemical binding]; other site 565034000542 uridine monophosphate binding site [chemical binding]; other site 565034000543 homohexameric interface [polypeptide binding]; other site 565034000544 hypothetical protein; Provisional; Region: PRK13665 565034000545 peroxiredoxin; Region: AhpC; TIGR03137 565034000546 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 565034000547 dimer interface [polypeptide binding]; other site 565034000548 decamer (pentamer of dimers) interface [polypeptide binding]; other site 565034000549 catalytic triad [active] 565034000550 peroxidatic and resolving cysteines [active] 565034000551 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 565034000552 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 565034000553 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 565034000554 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 565034000555 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 565034000556 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 565034000557 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 565034000558 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 565034000559 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565034000560 ABC transporter; Region: ABC_tran_2; pfam12848 565034000561 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 565034000562 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 565034000563 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 565034000564 active site 565034000565 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 565034000566 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 565034000567 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 565034000568 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 565034000569 catalytic residue [active] 565034000570 putative FPP diphosphate binding site; other site 565034000571 putative FPP binding hydrophobic cleft; other site 565034000572 dimer interface [polypeptide binding]; other site 565034000573 putative IPP diphosphate binding site; other site 565034000574 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 565034000575 ribosome recycling factor; Reviewed; Region: frr; PRK00083 565034000576 hinge region; other site 565034000577 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 565034000578 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 565034000579 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 565034000580 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 565034000581 Walker A/P-loop; other site 565034000582 ATP binding site [chemical binding]; other site 565034000583 Q-loop/lid; other site 565034000584 ABC transporter signature motif; other site 565034000585 Walker B; other site 565034000586 D-loop; other site 565034000587 H-loop/switch region; other site 565034000588 mce related protein; Region: MCE; pfam02470 565034000589 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 565034000590 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 565034000591 active site 565034000592 dimerization interface [polypeptide binding]; other site 565034000593 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 565034000594 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 565034000595 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 565034000596 alpha subunit interaction interface [polypeptide binding]; other site 565034000597 Walker A motif; other site 565034000598 ATP binding site [chemical binding]; other site 565034000599 Walker B motif; other site 565034000600 inhibitor binding site; inhibition site 565034000601 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 565034000602 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 565034000603 dimerization interface [polypeptide binding]; other site 565034000604 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034000605 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034000606 dimer interface [polypeptide binding]; other site 565034000607 putative CheW interface [polypeptide binding]; other site 565034000608 Eukaryotic cytochrome b(561); Region: Cyt_b561; cl14616 565034000609 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 565034000610 dimerization interface [polypeptide binding]; other site 565034000611 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034000612 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034000613 dimer interface [polypeptide binding]; other site 565034000614 putative CheW interface [polypeptide binding]; other site 565034000615 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 565034000616 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 565034000617 ligand binding site [chemical binding]; other site 565034000618 GTPase CgtA; Reviewed; Region: obgE; PRK12299 565034000619 GTP1/OBG; Region: GTP1_OBG; pfam01018 565034000620 Obg GTPase; Region: Obg; cd01898 565034000621 G1 box; other site 565034000622 GTP/Mg2+ binding site [chemical binding]; other site 565034000623 Switch I region; other site 565034000624 G2 box; other site 565034000625 G3 box; other site 565034000626 Switch II region; other site 565034000627 G4 box; other site 565034000628 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 565034000629 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034000630 FeS/SAM binding site; other site 565034000631 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034000632 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000633 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000634 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000635 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000636 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000637 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000638 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000639 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000640 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000641 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 565034000642 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000643 Ankyrin repeat; Region: Ank; pfam00023 565034000644 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 565034000645 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 565034000646 catalytic triad [active] 565034000647 conserved cis-peptide bond; other site 565034000648 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 565034000649 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 565034000650 DNA binding site [nucleotide binding] 565034000651 active site 565034000652 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 565034000653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 565034000654 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 565034000655 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 565034000656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034000657 Walker A motif; other site 565034000658 ATP binding site [chemical binding]; other site 565034000659 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 565034000660 DnaA box-binding interface [nucleotide binding]; other site 565034000661 GrpE; Region: GrpE; pfam01025 565034000662 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 565034000663 dimer interface [polypeptide binding]; other site 565034000664 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 565034000665 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 565034000666 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 565034000667 NEF interaction site [polypeptide binding]; other site 565034000668 nucleotide binding site [chemical binding]; other site 565034000669 SBD interface [polypeptide binding]; other site 565034000670 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000671 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000672 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000673 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000674 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000675 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000676 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000677 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034000678 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 565034000679 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000680 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000681 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000682 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000683 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000684 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000685 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 565034000686 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 565034000687 HSP70 interaction site [polypeptide binding]; other site 565034000688 chaperone protein DnaJ; Provisional; Region: PRK10767 565034000689 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 565034000690 HSP70 interaction site [polypeptide binding]; other site 565034000691 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 565034000692 substrate binding site [polypeptide binding]; other site 565034000693 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 565034000694 Zn binding sites [ion binding]; other site 565034000695 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 565034000696 dimer interface [polypeptide binding]; other site 565034000697 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 565034000698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034000699 TPR motif; other site 565034000700 binding surface 565034000701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034000702 TPR motif; other site 565034000703 TPR repeat; Region: TPR_11; pfam13414 565034000704 binding surface 565034000705 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 565034000706 dimer interface [polypeptide binding]; other site 565034000707 pyridoxal binding site [chemical binding]; other site 565034000708 ATP binding site [chemical binding]; other site 565034000709 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 565034000710 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 565034000711 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565034000712 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 565034000713 Soluble P-type ATPase [General function prediction only]; Region: COG4087 565034000714 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 565034000715 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 565034000716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034000717 TPR motif; other site 565034000718 binding surface 565034000719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034000720 binding surface 565034000721 TPR motif; other site 565034000722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034000723 binding surface 565034000724 TPR motif; other site 565034000725 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 565034000726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034000727 S-adenosylmethionine binding site [chemical binding]; other site 565034000728 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 565034000729 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 565034000730 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 565034000731 active site 565034000732 catalytic site [active] 565034000733 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 565034000734 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 565034000735 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565034000736 RNA binding surface [nucleotide binding]; other site 565034000737 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 565034000738 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565034000739 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034000740 ligand binding site [chemical binding]; other site 565034000741 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034000742 ligand binding site [chemical binding]; other site 565034000743 flexible hinge region; other site 565034000744 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565034000745 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034000746 ligand binding site [chemical binding]; other site 565034000747 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565034000748 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 565034000749 ligand binding site [chemical binding]; other site 565034000750 flexible hinge region; other site 565034000751 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034000752 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565034000753 ligand binding site [chemical binding]; other site 565034000754 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565034000755 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034000756 ligand binding site [chemical binding]; other site 565034000757 flexible hinge region; other site 565034000758 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565034000759 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034000760 ligand binding site [chemical binding]; other site 565034000761 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 565034000762 ligand binding site [chemical binding]; other site 565034000763 flexible hinge region; other site 565034000764 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034000765 ligand binding site [chemical binding]; other site 565034000766 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 565034000767 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034000768 ligand binding site [chemical binding]; other site 565034000769 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565034000770 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 565034000771 ligand binding site [chemical binding]; other site 565034000772 flexible hinge region; other site 565034000773 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565034000774 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034000775 ligand binding site [chemical binding]; other site 565034000776 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565034000777 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034000778 ligand binding site [chemical binding]; other site 565034000779 flexible hinge region; other site 565034000780 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 565034000781 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 565034000782 active site 565034000783 HIGH motif; other site 565034000784 dimer interface [polypeptide binding]; other site 565034000785 KMSKS motif; other site 565034000786 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 565034000787 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000788 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 565034000789 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000790 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000791 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000792 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000793 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000794 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000795 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000796 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000797 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000798 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000799 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034000800 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000801 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000802 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000803 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000804 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000805 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 565034000806 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 565034000807 phosphate binding site [ion binding]; other site 565034000808 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 565034000809 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 565034000810 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 565034000811 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 565034000812 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 565034000813 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 565034000814 EamA-like transporter family; Region: EamA; pfam00892 565034000815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565034000816 Major Facilitator Superfamily; Region: MFS_1; pfam07690 565034000817 putative substrate translocation pore; other site 565034000818 potential frameshift: common BLAST hit: gi|34498699|ref|NP_902914.1| N-acetylglucosamine metabolism protein 565034000819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034000820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034000821 active site 565034000822 motif I; other site 565034000823 motif II; other site 565034000824 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 565034000825 active site 565034000826 catalytic residues [active] 565034000827 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 565034000828 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 565034000829 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 565034000830 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 565034000831 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 565034000832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565034000833 dimer interface [polypeptide binding]; other site 565034000834 phosphorylation site [posttranslational modification] 565034000835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565034000836 ATP binding site [chemical binding]; other site 565034000837 Mg2+ binding site [ion binding]; other site 565034000838 G-X-G motif; other site 565034000839 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 565034000840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034000841 active site 565034000842 phosphorylation site [posttranslational modification] 565034000843 intermolecular recognition site; other site 565034000844 dimerization interface [polypeptide binding]; other site 565034000845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034000846 Walker A motif; other site 565034000847 ATP binding site [chemical binding]; other site 565034000848 Walker B motif; other site 565034000849 arginine finger; other site 565034000850 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 565034000851 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565034000852 HPr interaction site; other site 565034000853 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565034000854 active site 565034000855 phosphorylation site [posttranslational modification] 565034000856 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 565034000857 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565034000858 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565034000859 active site turn [active] 565034000860 phosphorylation site [posttranslational modification] 565034000861 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565034000862 active site turn [active] 565034000863 phosphorylation site [posttranslational modification] 565034000864 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 565034000865 active site turn [active] 565034000866 phosphorylation site [posttranslational modification] 565034000867 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 565034000868 active site turn [active] 565034000869 phosphorylation site [posttranslational modification] 565034000870 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 565034000871 active site turn [active] 565034000872 phosphorylation site [posttranslational modification] 565034000873 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 565034000874 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 565034000875 FMN binding site [chemical binding]; other site 565034000876 active site 565034000877 catalytic residues [active] 565034000878 substrate binding site [chemical binding]; other site 565034000879 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 565034000880 GAF domain; Region: GAF_3; pfam13492 565034000881 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 565034000882 GAF domain; Region: GAF; pfam01590 565034000883 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 565034000884 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 565034000885 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 565034000886 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 565034000887 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565034000888 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565034000889 active site 565034000890 catalytic tetrad [active] 565034000891 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565034000892 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565034000893 active site 565034000894 catalytic tetrad [active] 565034000895 Uncharacterized conserved protein [Function unknown]; Region: COG4925 565034000896 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 565034000897 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 565034000898 DNA binding residues [nucleotide binding] 565034000899 putative dimer interface [polypeptide binding]; other site 565034000900 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 565034000901 Phosphopantetheine attachment site; Region: PP-binding; cl09936 565034000902 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 565034000903 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 565034000904 AMP binding site [chemical binding]; other site 565034000905 active site 565034000906 acyl-activating enzyme (AAE) consensus motif; other site 565034000907 CoA binding site [chemical binding]; other site 565034000908 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 565034000909 putative acyl-acceptor binding pocket; other site 565034000910 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 565034000911 active site 565034000912 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 565034000913 Predicted exporter [General function prediction only]; Region: COG4258 565034000914 Predicted exporter [General function prediction only]; Region: COG4258 565034000915 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 565034000916 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 565034000917 dimer interface [polypeptide binding]; other site 565034000918 active site 565034000919 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 565034000920 active site 2 [active] 565034000921 active site 1 [active] 565034000922 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 565034000923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565034000924 NAD(P) binding site [chemical binding]; other site 565034000925 active site 565034000926 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000927 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000928 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000929 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000930 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 565034000931 dimer interface [polypeptide binding]; other site 565034000932 active site 565034000933 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 565034000934 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 565034000935 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 565034000936 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 565034000937 putative active site [active] 565034000938 putative hydrolase; Provisional; Region: PRK02113 565034000939 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 565034000940 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 565034000941 MgtE intracellular N domain; Region: MgtE_N; pfam03448 565034000942 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 565034000943 Divalent cation transporter; Region: MgtE; pfam01769 565034000944 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034000945 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000946 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000947 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000948 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000949 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000950 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000951 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034000952 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034000953 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 565034000954 EamA-like transporter family; Region: EamA; pfam00892 565034000955 EamA-like transporter family; Region: EamA; pfam00892 565034000956 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 565034000957 FOG: CBS domain [General function prediction only]; Region: COG0517 565034000958 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 565034000959 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 565034000960 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 565034000961 metal binding site [ion binding]; metal-binding site 565034000962 active site 565034000963 I-site; other site 565034000964 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 565034000965 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 565034000966 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 565034000967 active site 565034000968 homodimer interface [polypeptide binding]; other site 565034000969 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 565034000970 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 565034000971 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 565034000972 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 565034000973 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 565034000974 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 565034000975 HTH domain; Region: HTH_22; pfam13309 565034000976 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 565034000977 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 565034000978 active site 565034000979 DNA binding site [nucleotide binding] 565034000980 Int/Topo IB signature motif; other site 565034000981 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 565034000982 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 565034000983 substrate binding pocket [chemical binding]; other site 565034000984 membrane-bound complex binding site; other site 565034000985 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 565034000986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034000987 dimer interface [polypeptide binding]; other site 565034000988 conserved gate region; other site 565034000989 putative PBP binding loops; other site 565034000990 ABC-ATPase subunit interface; other site 565034000991 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 565034000992 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 565034000993 Walker A/P-loop; other site 565034000994 ATP binding site [chemical binding]; other site 565034000995 Q-loop/lid; other site 565034000996 ABC transporter signature motif; other site 565034000997 Walker B; other site 565034000998 D-loop; other site 565034000999 H-loop/switch region; other site 565034001000 Class I aldolases; Region: Aldolase_Class_I; cl17187 565034001001 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 565034001002 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565034001003 substrate binding pocket [chemical binding]; other site 565034001004 membrane-bound complex binding site; other site 565034001005 hinge residues; other site 565034001006 NMT1/THI5 like; Region: NMT1; pfam09084 565034001007 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565034001008 membrane-bound complex binding site; other site 565034001009 hinge residues; other site 565034001010 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565034001011 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 565034001012 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 565034001013 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 565034001014 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 565034001015 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 565034001016 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 565034001017 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 565034001018 HflX GTPase family; Region: HflX; cd01878 565034001019 G1 box; other site 565034001020 GTP/Mg2+ binding site [chemical binding]; other site 565034001021 Switch I region; other site 565034001022 G2 box; other site 565034001023 G3 box; other site 565034001024 Switch II region; other site 565034001025 G4 box; other site 565034001026 G5 box; other site 565034001027 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565034001028 Zn2+ binding site [ion binding]; other site 565034001029 Mg2+ binding site [ion binding]; other site 565034001030 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 565034001031 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 565034001032 Walker A/P-loop; other site 565034001033 ATP binding site [chemical binding]; other site 565034001034 Q-loop/lid; other site 565034001035 ABC transporter signature motif; other site 565034001036 Walker B; other site 565034001037 D-loop; other site 565034001038 H-loop/switch region; other site 565034001039 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 565034001040 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 565034001041 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 565034001042 Walker A/P-loop; other site 565034001043 ATP binding site [chemical binding]; other site 565034001044 Q-loop/lid; other site 565034001045 ABC transporter signature motif; other site 565034001046 Walker B; other site 565034001047 D-loop; other site 565034001048 H-loop/switch region; other site 565034001049 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 565034001050 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 565034001051 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 565034001052 Coenzyme A binding pocket [chemical binding]; other site 565034001053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 565034001054 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 565034001055 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 565034001056 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 565034001057 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 565034001058 GTP/Mg2+ binding site [chemical binding]; other site 565034001059 G4 box; other site 565034001060 G5 box; other site 565034001061 trmE is a tRNA modification GTPase; Region: trmE; cd04164 565034001062 G1 box; other site 565034001063 G1 box; other site 565034001064 GTP/Mg2+ binding site [chemical binding]; other site 565034001065 Switch I region; other site 565034001066 Switch I region; other site 565034001067 G2 box; other site 565034001068 G2 box; other site 565034001069 Switch II region; other site 565034001070 G3 box; other site 565034001071 G3 box; other site 565034001072 Switch II region; other site 565034001073 G4 box; other site 565034001074 G5 box; other site 565034001075 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 565034001076 TraB family; Region: TraB; cl12050 565034001077 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 565034001078 Transglycosylase; Region: Transgly; pfam00912 565034001079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 565034001080 META domain; Region: META; pfam03724 565034001081 META domain; Region: META; pfam03724 565034001082 META domain; Region: META; pfam03724 565034001083 META domain; Region: META; pfam03724 565034001084 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 565034001085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565034001086 Coenzyme A binding pocket [chemical binding]; other site 565034001087 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 565034001088 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 565034001089 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 565034001090 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 565034001091 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 565034001092 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 565034001093 FHIPEP family; Region: FHIPEP; pfam00771 565034001094 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 565034001095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034001096 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 565034001097 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 565034001098 Walker A/P-loop; other site 565034001099 ATP binding site [chemical binding]; other site 565034001100 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 565034001101 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 565034001102 P-loop; other site 565034001103 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 565034001104 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 565034001105 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 565034001106 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 565034001107 DNA binding residues [nucleotide binding] 565034001108 Protein of unknown function (DUF342); Region: DUF342; pfam03961 565034001109 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 565034001110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034001111 motif II; other site 565034001112 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 565034001113 Recombination protein O N terminal; Region: RecO_N; pfam11967 565034001114 Recombination protein O C terminal; Region: RecO_C; pfam02565 565034001115 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 565034001116 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 565034001117 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 565034001118 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 565034001119 selenocysteine synthase; Provisional; Region: PRK04311 565034001120 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 565034001121 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001122 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001123 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001124 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001125 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 565034001126 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 565034001127 G1 box; other site 565034001128 putative GEF interaction site [polypeptide binding]; other site 565034001129 GTP/Mg2+ binding site [chemical binding]; other site 565034001130 Switch I region; other site 565034001131 G2 box; other site 565034001132 G3 box; other site 565034001133 Switch II region; other site 565034001134 G4 box; other site 565034001135 G5 box; other site 565034001136 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 565034001137 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 565034001138 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 565034001139 dimer interface [polypeptide binding]; other site 565034001140 putative tRNA-binding site [nucleotide binding]; other site 565034001141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034001142 Tetratricopeptide repeat; Region: TPR_16; pfam13432 565034001143 binding surface 565034001144 TPR motif; other site 565034001145 excinuclease ABC subunit B; Provisional; Region: PRK05298 565034001146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565034001147 ATP binding site [chemical binding]; other site 565034001148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565034001149 nucleotide binding region [chemical binding]; other site 565034001150 ATP-binding site [chemical binding]; other site 565034001151 Ultra-violet resistance protein B; Region: UvrB; pfam12344 565034001152 UvrB/uvrC motif; Region: UVR; pfam02151 565034001153 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 565034001154 Peptidase family M23; Region: Peptidase_M23; pfam01551 565034001155 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 565034001156 Peptidase family M23; Region: Peptidase_M23; pfam01551 565034001157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034001158 binding surface 565034001159 TPR motif; other site 565034001160 TPR repeat; Region: TPR_11; pfam13414 565034001161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034001162 TPR motif; other site 565034001163 binding surface 565034001164 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 565034001165 nucleophile elbow; other site 565034001166 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 565034001167 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 565034001168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034001169 motif II; other site 565034001170 regulatory ATPase RavA; Provisional; Region: PRK13531 565034001171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034001172 Walker A motif; other site 565034001173 ATP binding site [chemical binding]; other site 565034001174 Walker B motif; other site 565034001175 arginine finger; other site 565034001176 hypothetical protein; Provisional; Region: yieM; PRK10997 565034001177 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 565034001178 metal ion-dependent adhesion site (MIDAS); other site 565034001179 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 565034001180 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 565034001181 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 565034001182 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 565034001183 active site 565034001184 catalytic residues [active] 565034001185 metal binding site [ion binding]; metal-binding site 565034001186 homodimer binding site [polypeptide binding]; other site 565034001187 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 565034001188 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 565034001189 carboxyltransferase (CT) interaction site; other site 565034001190 biotinylation site [posttranslational modification]; other site 565034001191 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 565034001192 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 565034001193 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 565034001194 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 565034001195 Predicted transcriptional regulators [Transcription]; Region: COG1733 565034001196 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 565034001197 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 565034001198 hydrophobic ligand binding site; other site 565034001199 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 565034001200 Domain of unknown function DUF20; Region: UPF0118; pfam01594 565034001201 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001202 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034001203 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034001204 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 565034001205 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 565034001206 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 565034001207 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 565034001208 zinc binding site [ion binding]; other site 565034001209 putative ligand binding site [chemical binding]; other site 565034001210 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 565034001211 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 565034001212 TM-ABC transporter signature motif; other site 565034001213 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 565034001214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034001215 Walker A/P-loop; other site 565034001216 ATP binding site [chemical binding]; other site 565034001217 Q-loop/lid; other site 565034001218 ABC transporter signature motif; other site 565034001219 Walker B; other site 565034001220 D-loop; other site 565034001221 H-loop/switch region; other site 565034001222 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 565034001223 PhoU domain; Region: PhoU; pfam01895 565034001224 PhoU domain; Region: PhoU; pfam01895 565034001225 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 565034001226 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 565034001227 Walker A/P-loop; other site 565034001228 ATP binding site [chemical binding]; other site 565034001229 Q-loop/lid; other site 565034001230 ABC transporter signature motif; other site 565034001231 Walker B; other site 565034001232 D-loop; other site 565034001233 H-loop/switch region; other site 565034001234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034001235 dimer interface [polypeptide binding]; other site 565034001236 conserved gate region; other site 565034001237 putative PBP binding loops; other site 565034001238 ABC-ATPase subunit interface; other site 565034001239 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 565034001240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034001241 dimer interface [polypeptide binding]; other site 565034001242 conserved gate region; other site 565034001243 putative PBP binding loops; other site 565034001244 ABC-ATPase subunit interface; other site 565034001245 PBP superfamily domain; Region: PBP_like_2; cl17296 565034001246 ATP cone domain; Region: ATP-cone; pfam03477 565034001247 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 565034001248 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 565034001249 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 565034001250 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 565034001251 dimer interface [polypeptide binding]; other site 565034001252 putative radical transfer pathway; other site 565034001253 diiron center [ion binding]; other site 565034001254 tyrosyl radical; other site 565034001255 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 565034001256 Methyltransferase domain; Region: Methyltransf_26; pfam13659 565034001257 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 565034001258 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 565034001259 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 565034001260 Predicted solute binding protein [General function prediction only]; Region: COG3889 565034001261 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034001262 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001263 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001264 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 565034001265 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001266 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001267 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034001268 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001269 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001270 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001271 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 565034001272 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 565034001273 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 565034001274 substrate binding site [chemical binding]; other site 565034001275 putative active site [active] 565034001276 putative cosubstrate binding site; other site 565034001277 catalytic site [active] 565034001278 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 565034001279 substrate binding site [chemical binding]; other site 565034001280 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 565034001281 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 565034001282 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 565034001283 Methyltransferase domain; Region: Methyltransf_23; pfam13489 565034001284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034001285 S-adenosylmethionine binding site [chemical binding]; other site 565034001286 Protein of unknown function (DUF342); Region: DUF342; pfam03961 565034001287 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 565034001288 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 565034001289 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 565034001290 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 565034001291 Cache domain; Region: Cache_1; pfam02743 565034001292 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034001293 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034001294 dimer interface [polypeptide binding]; other site 565034001295 putative CheW interface [polypeptide binding]; other site 565034001296 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 565034001297 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 565034001298 active site 565034001299 catalytic triad [active] 565034001300 dimer interface [polypeptide binding]; other site 565034001301 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 565034001302 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 565034001303 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 565034001304 putative active site [active] 565034001305 catalytic site [active] 565034001306 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 565034001307 putative active site [active] 565034001308 catalytic site [active] 565034001309 Sm and related proteins; Region: Sm_like; cl00259 565034001310 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 565034001311 NusA N-terminal domain; Region: NusA_N; pfam08529 565034001312 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 565034001313 RNA binding site [nucleotide binding]; other site 565034001314 homodimer interface [polypeptide binding]; other site 565034001315 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 565034001316 G-X-X-G motif; other site 565034001317 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 565034001318 G-X-X-G motif; other site 565034001319 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 565034001320 Methyltransferase domain; Region: Methyltransf_23; pfam13489 565034001321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034001322 S-adenosylmethionine binding site [chemical binding]; other site 565034001323 Cache domain; Region: Cache_1; pfam02743 565034001324 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034001325 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034001326 dimer interface [polypeptide binding]; other site 565034001327 putative CheW interface [polypeptide binding]; other site 565034001328 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 565034001329 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 565034001330 tetramer interface [polypeptide binding]; other site 565034001331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034001332 catalytic residue [active] 565034001333 adenylosuccinate lyase; Provisional; Region: PRK07492 565034001334 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 565034001335 tetramer interface [polypeptide binding]; other site 565034001336 active site 565034001337 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 565034001338 UGMP family protein; Validated; Region: PRK09604 565034001339 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 565034001340 Sulfatase; Region: Sulfatase; cl17466 565034001341 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 565034001342 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 565034001343 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 565034001344 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 565034001345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034001346 dimer interface [polypeptide binding]; other site 565034001347 conserved gate region; other site 565034001348 putative PBP binding loops; other site 565034001349 ABC-ATPase subunit interface; other site 565034001350 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 565034001351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034001352 dimer interface [polypeptide binding]; other site 565034001353 conserved gate region; other site 565034001354 putative PBP binding loops; other site 565034001355 ABC-ATPase subunit interface; other site 565034001356 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 565034001357 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 565034001358 Walker A/P-loop; other site 565034001359 ATP binding site [chemical binding]; other site 565034001360 Q-loop/lid; other site 565034001361 ABC transporter signature motif; other site 565034001362 Walker B; other site 565034001363 D-loop; other site 565034001364 H-loop/switch region; other site 565034001365 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 565034001366 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 565034001367 Walker A/P-loop; other site 565034001368 ATP binding site [chemical binding]; other site 565034001369 Q-loop/lid; other site 565034001370 ABC transporter signature motif; other site 565034001371 Walker B; other site 565034001372 D-loop; other site 565034001373 H-loop/switch region; other site 565034001374 Transcriptional regulators [Transcription]; Region: PurR; COG1609 565034001375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565034001376 DNA binding site [nucleotide binding] 565034001377 domain linker motif; other site 565034001378 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 565034001379 ligand binding site [chemical binding]; other site 565034001380 HsdM N-terminal domain; Region: HsdM_N; pfam12161 565034001381 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 565034001382 Methyltransferase domain; Region: Methyltransf_26; pfam13659 565034001383 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 565034001384 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 565034001385 active site 565034001386 NTP binding site [chemical binding]; other site 565034001387 metal binding triad [ion binding]; metal-binding site 565034001388 antibiotic binding site [chemical binding]; other site 565034001389 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 565034001390 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 565034001391 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 565034001392 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 565034001393 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 565034001394 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565034001395 ATP binding site [chemical binding]; other site 565034001396 putative Mg++ binding site [ion binding]; other site 565034001397 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 565034001398 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 565034001399 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 565034001400 catalytic residue [active] 565034001401 Protein of unknown function (DUF327); Region: DUF327; pfam03885 565034001402 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 565034001403 Glycoprotease family; Region: Peptidase_M22; pfam00814 565034001404 Cache domain; Region: Cache_1; pfam02743 565034001405 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 565034001406 HAMP domain; Region: HAMP; pfam00672 565034001407 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034001408 dimer interface [polypeptide binding]; other site 565034001409 putative CheW interface [polypeptide binding]; other site 565034001410 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 565034001411 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 565034001412 active site residue [active] 565034001413 AAA domain; Region: AAA_17; pfam13207 565034001414 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 565034001415 PSP1 C-terminal conserved region; Region: PSP1; cl00770 565034001416 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 565034001417 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 565034001418 active site 565034001419 HIGH motif; other site 565034001420 dimer interface [polypeptide binding]; other site 565034001421 KMSKS motif; other site 565034001422 YceG-like family; Region: YceG; pfam02618 565034001423 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 565034001424 dimerization interface [polypeptide binding]; other site 565034001425 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 565034001426 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 565034001427 dimer interface [polypeptide binding]; other site 565034001428 motif 1; other site 565034001429 active site 565034001430 motif 2; other site 565034001431 motif 3; other site 565034001432 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 565034001433 anticodon binding site; other site 565034001434 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 565034001435 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 565034001436 chromosome segregation protein; Provisional; Region: PRK01156 565034001437 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 565034001438 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 565034001439 trimer interface [polypeptide binding]; other site 565034001440 active site 565034001441 fructuronate transporter; Provisional; Region: PRK10034; cl15264 565034001442 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 565034001443 dimerization domain swap beta strand [polypeptide binding]; other site 565034001444 regulatory protein interface [polypeptide binding]; other site 565034001445 active site 565034001446 regulatory phosphorylation site [posttranslational modification]; other site 565034001447 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034001448 FeS/SAM binding site; other site 565034001449 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 565034001450 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 565034001451 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 565034001452 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 565034001453 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 565034001454 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 565034001455 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 565034001456 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 565034001457 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 565034001458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034001459 Walker A/P-loop; other site 565034001460 ATP binding site [chemical binding]; other site 565034001461 Q-loop/lid; other site 565034001462 ABC transporter signature motif; other site 565034001463 Walker B; other site 565034001464 D-loop; other site 565034001465 H-loop/switch region; other site 565034001466 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 565034001467 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 565034001468 Cache domain; Region: Cache_1; pfam02743 565034001469 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 565034001470 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034001471 dimer interface [polypeptide binding]; other site 565034001472 putative CheW interface [polypeptide binding]; other site 565034001473 potential frameshift: common BLAST hit: gi|152990298|ref|YP_001356020.1| 5-methyltetrahydrofolate--homocysteine methyltransferase 565034001474 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 565034001475 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 565034001476 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 565034001477 substrate binding pocket [chemical binding]; other site 565034001478 dimer interface [polypeptide binding]; other site 565034001479 inhibitor binding site; inhibition site 565034001480 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 565034001481 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 565034001482 B12 binding site [chemical binding]; other site 565034001483 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 565034001484 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 565034001485 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 565034001486 FAD binding site [chemical binding]; other site 565034001487 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034001488 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 565034001489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034001490 active site 565034001491 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 565034001492 putative trimer interface [polypeptide binding]; other site 565034001493 putative CoA binding site [chemical binding]; other site 565034001494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 565034001495 Predicted permeases [General function prediction only]; Region: COG0795 565034001496 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 565034001497 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 565034001498 prolyl-tRNA synthetase; Provisional; Region: PRK09194 565034001499 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 565034001500 dimer interface [polypeptide binding]; other site 565034001501 motif 1; other site 565034001502 active site 565034001503 motif 2; other site 565034001504 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 565034001505 putative deacylase active site [active] 565034001506 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 565034001507 active site 565034001508 motif 3; other site 565034001509 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 565034001510 anticodon binding site; other site 565034001511 Methyltransferase domain; Region: Methyltransf_24; pfam13578 565034001512 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 565034001513 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 565034001514 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 565034001515 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 565034001516 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 565034001517 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 565034001518 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 565034001519 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001520 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034001521 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001522 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 565034001523 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001524 Ankyrin repeat; Region: Ank; pfam00023 565034001525 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001526 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001527 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001528 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034001529 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 565034001530 ligand binding site [chemical binding]; other site 565034001531 flexible hinge region; other site 565034001532 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 565034001533 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565034001534 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034001535 ligand binding site [chemical binding]; other site 565034001536 flexible hinge region; other site 565034001537 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 565034001538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034001539 binding surface 565034001540 TPR motif; other site 565034001541 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 565034001542 NAD synthetase; Provisional; Region: PRK13981 565034001543 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 565034001544 multimer interface [polypeptide binding]; other site 565034001545 active site 565034001546 catalytic triad [active] 565034001547 protein interface 1 [polypeptide binding]; other site 565034001548 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 565034001549 Ligand Binding Site [chemical binding]; other site 565034001550 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 565034001551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034001552 active site 565034001553 phosphorylation site [posttranslational modification] 565034001554 intermolecular recognition site; other site 565034001555 dimerization interface [polypeptide binding]; other site 565034001556 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 565034001557 putative binding surface; other site 565034001558 active site 565034001559 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 565034001560 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 565034001561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565034001562 ATP binding site [chemical binding]; other site 565034001563 Mg2+ binding site [ion binding]; other site 565034001564 G-X-G motif; other site 565034001565 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 565034001566 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 565034001567 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 565034001568 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 565034001569 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 565034001570 CheD chemotactic sensory transduction; Region: CheD; cl00810 565034001571 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 565034001572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034001573 active site 565034001574 phosphorylation site [posttranslational modification] 565034001575 intermolecular recognition site; other site 565034001576 dimerization interface [polypeptide binding]; other site 565034001577 CheB methylesterase; Region: CheB_methylest; pfam01339 565034001578 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 565034001579 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 565034001580 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 565034001581 Predicted transcriptional regulator [Transcription]; Region: COG2378 565034001582 WYL domain; Region: WYL; pfam13280 565034001583 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 565034001584 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 565034001585 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 565034001586 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 565034001587 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 565034001588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565034001589 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 565034001590 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 565034001591 Ca binding site [ion binding]; other site 565034001592 active site 565034001593 catalytic site [active] 565034001594 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565034001595 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 565034001596 active site turn [active] 565034001597 phosphorylation site [posttranslational modification] 565034001598 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565034001599 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 565034001600 HPr interaction site; other site 565034001601 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565034001602 active site 565034001603 phosphorylation site [posttranslational modification] 565034001604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565034001605 DNA-binding site [nucleotide binding]; DNA binding site 565034001606 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 565034001607 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 565034001608 Outer membrane efflux protein; Region: OEP; pfam02321 565034001609 Outer membrane efflux protein; Region: OEP; pfam02321 565034001610 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 565034001611 Protein export membrane protein; Region: SecD_SecF; cl14618 565034001612 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 565034001613 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 565034001614 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 565034001615 phosphate binding site [ion binding]; other site 565034001616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034001617 TPR motif; other site 565034001618 binding surface 565034001619 TPR repeat; Region: TPR_11; pfam13414 565034001620 TPR repeat; Region: TPR_11; pfam13414 565034001621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034001622 binding surface 565034001623 TPR motif; other site 565034001624 elongation factor Ts; Provisional; Region: tsf; PRK09377 565034001625 UBA/TS-N domain; Region: UBA; pfam00627 565034001626 Elongation factor TS; Region: EF_TS; pfam00889 565034001627 Elongation factor TS; Region: EF_TS; pfam00889 565034001628 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 565034001629 rRNA interaction site [nucleotide binding]; other site 565034001630 S8 interaction site; other site 565034001631 putative laminin-1 binding site; other site 565034001632 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 565034001633 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565034001634 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 565034001635 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 565034001636 nucleotide binding site [chemical binding]; other site 565034001637 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 565034001638 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 565034001639 substrate binding site [chemical binding]; other site 565034001640 ATP binding site [chemical binding]; other site 565034001641 serine O-acetyltransferase; Region: cysE; TIGR01172 565034001642 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 565034001643 trimer interface [polypeptide binding]; other site 565034001644 active site 565034001645 substrate binding site [chemical binding]; other site 565034001646 CoA binding site [chemical binding]; other site 565034001647 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 565034001648 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 565034001649 dimer interface [polypeptide binding]; other site 565034001650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034001651 catalytic residue [active] 565034001652 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 565034001653 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 565034001654 metal binding site [ion binding]; metal-binding site 565034001655 dimer interface [polypeptide binding]; other site 565034001656 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034001657 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034001658 peptide binding site [polypeptide binding]; other site 565034001659 Cache domain; Region: Cache_1; pfam02743 565034001660 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034001661 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034001662 dimer interface [polypeptide binding]; other site 565034001663 putative CheW interface [polypeptide binding]; other site 565034001664 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cd00528 565034001665 trimer interface [polypeptide binding]; other site 565034001666 dimer interface [polypeptide binding]; other site 565034001667 putative active site [active] 565034001668 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 565034001669 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034001670 FeS/SAM binding site; other site 565034001671 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 565034001672 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 565034001673 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 565034001674 dimer interface [polypeptide binding]; other site 565034001675 putative functional site; other site 565034001676 putative MPT binding site; other site 565034001677 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 565034001678 XdhC Rossmann domain; Region: XdhC_C; pfam13478 565034001679 MOSC domain; Region: MOSC; pfam03473 565034001680 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 565034001681 MPT binding site; other site 565034001682 trimer interface [polypeptide binding]; other site 565034001683 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 565034001684 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 565034001685 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 565034001686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034001687 putative PBP binding loops; other site 565034001688 dimer interface [polypeptide binding]; other site 565034001689 ABC-ATPase subunit interface; other site 565034001690 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 565034001691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034001692 Walker A/P-loop; other site 565034001693 ATP binding site [chemical binding]; other site 565034001694 Q-loop/lid; other site 565034001695 ABC transporter signature motif; other site 565034001696 Walker B; other site 565034001697 D-loop; other site 565034001698 H-loop/switch region; other site 565034001699 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034001700 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 565034001701 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565034001702 RNA binding surface [nucleotide binding]; other site 565034001703 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 565034001704 active site 565034001705 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 565034001706 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 565034001707 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 565034001708 Walker A/P-loop; other site 565034001709 ATP binding site [chemical binding]; other site 565034001710 Q-loop/lid; other site 565034001711 ABC transporter signature motif; other site 565034001712 Walker B; other site 565034001713 D-loop; other site 565034001714 H-loop/switch region; other site 565034001715 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 565034001716 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 565034001717 ABC-ATPase subunit interface; other site 565034001718 dimer interface [polypeptide binding]; other site 565034001719 putative PBP binding regions; other site 565034001720 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 565034001721 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 565034001722 intersubunit interface [polypeptide binding]; other site 565034001723 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 565034001724 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 565034001725 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 565034001726 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 565034001727 heterotetramer interface [polypeptide binding]; other site 565034001728 active site pocket [active] 565034001729 cleavage site 565034001730 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 565034001731 feedback inhibition sensing region; other site 565034001732 homohexameric interface [polypeptide binding]; other site 565034001733 nucleotide binding site [chemical binding]; other site 565034001734 N-acetyl-L-glutamate binding site [chemical binding]; other site 565034001735 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 565034001736 acetylornithine aminotransferase; Provisional; Region: PRK02627 565034001737 inhibitor-cofactor binding pocket; inhibition site 565034001738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034001739 catalytic residue [active] 565034001740 potential frameshift: common BLAST hit: gi|52078801|ref|YP_077592.1| ABC transporter 565034001741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034001742 H-loop/switch region; other site 565034001743 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 565034001744 Walker A/P-loop; other site 565034001745 ATP binding site [chemical binding]; other site 565034001746 ABC transporter; Region: ABC_tran; pfam00005 565034001747 Q-loop/lid; other site 565034001748 ABC transporter signature motif; other site 565034001749 Walker B; other site 565034001750 D-loop; other site 565034001751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565034001752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565034001753 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 565034001754 Cache domain; Region: Cache_1; pfam02743 565034001755 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 565034001756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034001757 dimerization interface [polypeptide binding]; other site 565034001758 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034001759 dimer interface [polypeptide binding]; other site 565034001760 putative CheW interface [polypeptide binding]; other site 565034001761 Hemerythrin; Region: Hemerythrin; cd12107 565034001762 Fe binding site [ion binding]; other site 565034001763 Cache domain; Region: Cache_1; pfam02743 565034001764 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034001765 dimerization interface [polypeptide binding]; other site 565034001766 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034001767 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034001768 dimer interface [polypeptide binding]; other site 565034001769 putative CheW interface [polypeptide binding]; other site 565034001770 Hemerythrin; Region: Hemerythrin; cd12107 565034001771 Fe binding site [ion binding]; other site 565034001772 flagellin; Provisional; Region: PRK12803 565034001773 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 565034001774 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 565034001775 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 565034001776 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 565034001777 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 565034001778 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 565034001779 acyl-activating enzyme (AAE) consensus motif; other site 565034001780 putative AMP binding site [chemical binding]; other site 565034001781 putative active site [active] 565034001782 putative CoA binding site [chemical binding]; other site 565034001783 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 565034001784 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 565034001785 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 565034001786 Methyltransferase domain; Region: Methyltransf_23; pfam13489 565034001787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034001788 S-adenosylmethionine binding site [chemical binding]; other site 565034001789 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 565034001790 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 565034001791 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 565034001792 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 565034001793 phosphoserine phosphatase SerB; Region: serB; TIGR00338 565034001794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034001795 motif II; other site 565034001796 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 565034001797 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 565034001798 ligand binding site [chemical binding]; other site 565034001799 NAD binding site [chemical binding]; other site 565034001800 dimerization interface [polypeptide binding]; other site 565034001801 catalytic site [active] 565034001802 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 565034001803 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 565034001804 homodimer interface [polypeptide binding]; other site 565034001805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034001806 catalytic residue [active] 565034001807 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 565034001808 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034001809 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034001810 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 565034001811 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 565034001812 N-acetyl-D-glucosamine binding site [chemical binding]; other site 565034001813 catalytic residue [active] 565034001814 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 565034001815 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 565034001816 N-acetyl-D-glucosamine binding site [chemical binding]; other site 565034001817 catalytic residue [active] 565034001818 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 565034001819 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 565034001820 NAD(P) binding site [chemical binding]; other site 565034001821 catalytic residues [active] 565034001822 Stage II sporulation protein; Region: SpoIID; pfam08486 565034001823 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 565034001824 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 565034001825 Sulfatase; Region: Sulfatase; cl17466 565034001826 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 565034001827 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 565034001828 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 565034001829 active site 565034001830 metal-binding site 565034001831 Phosphotransferase enzyme family; Region: APH; pfam01636 565034001832 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 565034001833 active site 565034001834 substrate binding site [chemical binding]; other site 565034001835 ATP binding site [chemical binding]; other site 565034001836 dimer interface [polypeptide binding]; other site 565034001837 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 565034001838 active site 565034001839 metal-binding site 565034001840 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 565034001841 active site 565034001842 ATP binding site [chemical binding]; other site 565034001843 Phosphotransferase enzyme family; Region: APH; pfam01636 565034001844 substrate binding site [chemical binding]; other site 565034001845 dimer interface [polypeptide binding]; other site 565034001846 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 565034001847 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 565034001848 Sulfatase; Region: Sulfatase; cl17466 565034001849 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 565034001850 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 565034001851 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 565034001852 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 565034001853 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 565034001854 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 565034001855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565034001856 Coenzyme A binding pocket [chemical binding]; other site 565034001857 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 565034001858 methionine sulfoxide reductase B; Provisional; Region: PRK05508 565034001859 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 565034001860 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 565034001861 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 565034001862 Clp amino terminal domain; Region: Clp_N; pfam02861 565034001863 Clp amino terminal domain; Region: Clp_N; pfam02861 565034001864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034001865 Walker A motif; other site 565034001866 ATP binding site [chemical binding]; other site 565034001867 Walker B motif; other site 565034001868 arginine finger; other site 565034001869 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 565034001870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034001871 Walker A motif; other site 565034001872 ATP binding site [chemical binding]; other site 565034001873 Walker B motif; other site 565034001874 arginine finger; other site 565034001875 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 565034001876 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 565034001877 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 565034001878 active site 565034001879 PHP Thumb interface [polypeptide binding]; other site 565034001880 metal binding site [ion binding]; metal-binding site 565034001881 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 565034001882 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 565034001883 substrate binding site [chemical binding]; other site 565034001884 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 565034001885 Domain of unknown function DUF21; Region: DUF21; pfam01595 565034001886 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 565034001887 Transporter associated domain; Region: CorC_HlyC; smart01091 565034001888 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 565034001889 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 565034001890 putative active site [active] 565034001891 putative metal binding site [ion binding]; other site 565034001892 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 565034001893 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001894 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001895 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001896 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034001897 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001898 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001899 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001900 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001901 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001902 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001903 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001904 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001905 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 565034001906 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001907 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001908 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001909 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001910 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001911 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001912 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001913 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001914 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001915 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034001916 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034001917 Formaldehyde dehydrogenases; Region: FDH_like; cd05278 565034001918 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 565034001919 catalytic Zn binding site [ion binding]; other site 565034001920 NAD(P) binding site [chemical binding]; other site 565034001921 structural Zn binding site [ion binding]; other site 565034001922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565034001923 Coenzyme A binding pocket [chemical binding]; other site 565034001924 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 565034001925 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 565034001926 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 565034001927 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 565034001928 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 565034001929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565034001930 Mg2+ binding site [ion binding]; other site 565034001931 G-X-G motif; other site 565034001932 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 565034001933 anchoring element; other site 565034001934 dimer interface [polypeptide binding]; other site 565034001935 ATP binding site [chemical binding]; other site 565034001936 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 565034001937 active site 565034001938 putative metal-binding site [ion binding]; other site 565034001939 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 565034001940 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565034001941 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 565034001942 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565034001943 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 565034001944 active site 565034001945 P-loop; other site 565034001946 phosphorylation site [posttranslational modification] 565034001947 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 565034001948 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 565034001949 membrane-bound complex binding site; other site 565034001950 hinge residues; other site 565034001951 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 565034001952 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 565034001953 active site 565034001954 (T/H)XGH motif; other site 565034001955 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 565034001956 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 565034001957 active site 565034001958 metal binding site [ion binding]; metal-binding site 565034001959 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 565034001960 oligoendopeptidase F; Region: pepF; TIGR00181 565034001961 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 565034001962 active site 565034001963 Zn binding site [ion binding]; other site 565034001964 TM2 domain; Region: TM2; pfam05154 565034001965 homoserine kinase; Provisional; Region: PRK01212 565034001966 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 565034001967 threonine synthase; Reviewed; Region: PRK06721 565034001968 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 565034001969 homodimer interface [polypeptide binding]; other site 565034001970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034001971 catalytic residue [active] 565034001972 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 565034001973 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 565034001974 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 565034001975 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 565034001976 Bacitracin resistance protein BacA; Region: BacA; pfam02673 565034001977 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 565034001978 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 565034001979 RNA binding site [nucleotide binding]; other site 565034001980 active site 565034001981 Dehydroquinase class II; Region: DHquinase_II; pfam01220 565034001982 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 565034001983 trimer interface [polypeptide binding]; other site 565034001984 active site 565034001985 dimer interface [polypeptide binding]; other site 565034001986 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 565034001987 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 565034001988 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 565034001989 active site 565034001990 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 565034001991 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 565034001992 oligomer interface [polypeptide binding]; other site 565034001993 active site 565034001994 metal binding site [ion binding]; metal-binding site 565034001995 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 565034001996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034001997 binding surface 565034001998 TPR repeat; Region: TPR_11; pfam13414 565034001999 N-glycosylase/DNA lyase; Provisional; Region: PRK01229 565034002000 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 565034002001 minor groove reading motif; other site 565034002002 helix-hairpin-helix signature motif; other site 565034002003 active site 565034002004 LexA repressor; Validated; Region: PRK00215 565034002005 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 565034002006 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 565034002007 Catalytic site [active] 565034002008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 565034002009 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 565034002010 glycogen synthase; Provisional; Region: glgA; PRK00654 565034002011 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 565034002012 ADP-binding pocket [chemical binding]; other site 565034002013 homodimer interface [polypeptide binding]; other site 565034002014 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 565034002015 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 565034002016 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 565034002017 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 565034002018 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 565034002019 Permease; Region: Permease; pfam02405 565034002020 replicative DNA helicase; Region: DnaB; TIGR00665 565034002021 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 565034002022 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 565034002023 Walker A motif; other site 565034002024 ATP binding site [chemical binding]; other site 565034002025 Walker B motif; other site 565034002026 DNA binding loops [nucleotide binding] 565034002027 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 565034002028 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 565034002029 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 565034002030 Flavodoxin domain; Region: Flavodoxin_3; pfam12641 565034002031 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 565034002032 active site 565034002033 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 565034002034 nucleotide binding site/active site [active] 565034002035 HIT family signature motif; other site 565034002036 catalytic residue [active] 565034002037 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 565034002038 ZIP Zinc transporter; Region: Zip; pfam02535 565034002039 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 565034002040 Serine hydrolase (FSH1); Region: FSH1; pfam03959 565034002041 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 565034002042 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034002043 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 565034002044 anti sigma factor interaction site; other site 565034002045 regulatory phosphorylation site [posttranslational modification]; other site 565034002046 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 565034002047 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 565034002048 Protein export membrane protein; Region: SecD_SecF; cl14618 565034002049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565034002050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565034002051 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 565034002052 dimerization interface [polypeptide binding]; other site 565034002053 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 565034002054 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 565034002055 DNA binding residues [nucleotide binding] 565034002056 putative dimer interface [polypeptide binding]; other site 565034002057 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 565034002058 trimer interface [polypeptide binding]; other site 565034002059 active site 565034002060 substrate binding site [chemical binding]; other site 565034002061 CoA binding site [chemical binding]; other site 565034002062 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034002063 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 565034002064 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 565034002065 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 565034002066 Uncharacterized conserved protein [Function unknown]; Region: COG4925 565034002067 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565034002068 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565034002069 active site 565034002070 catalytic tetrad [active] 565034002071 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 565034002072 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 565034002073 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 565034002074 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 565034002075 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 565034002076 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 565034002077 RNB domain; Region: RNB; pfam00773 565034002078 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 565034002079 RNA binding site [nucleotide binding]; other site 565034002080 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034002081 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034002082 NHL repeat; Region: NHL; pfam01436 565034002083 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 565034002084 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 565034002085 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 565034002086 N-acetyl-D-glucosamine binding site [chemical binding]; other site 565034002087 catalytic residue [active] 565034002088 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 565034002089 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 565034002090 Walker A motif/ATP binding site; other site 565034002091 Walker B motif; other site 565034002092 flagellar assembly protein H; Validated; Region: fliH; PRK06669 565034002093 Flagellar assembly protein FliH; Region: FliH; pfam02108 565034002094 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 565034002095 FliG C-terminal domain; Region: FliG_C; pfam01706 565034002096 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 565034002097 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 565034002098 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 565034002099 Competence-damaged protein; Region: CinA; pfam02464 565034002100 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 565034002101 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 565034002102 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 565034002103 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 565034002104 catalytic site [active] 565034002105 G-X2-G-X-G-K; other site 565034002106 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 565034002107 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 565034002108 active site 565034002109 HIGH motif; other site 565034002110 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 565034002111 active site 565034002112 KMSKS motif; other site 565034002113 Response regulator receiver domain; Region: Response_reg; pfam00072 565034002114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034002115 active site 565034002116 phosphorylation site [posttranslational modification] 565034002117 intermolecular recognition site; other site 565034002118 dimerization interface [polypeptide binding]; other site 565034002119 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 565034002120 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 565034002121 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 565034002122 NADP binding site [chemical binding]; other site 565034002123 homopentamer interface [polypeptide binding]; other site 565034002124 substrate binding site [chemical binding]; other site 565034002125 active site 565034002126 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 565034002127 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 565034002128 active site 565034002129 HIGH motif; other site 565034002130 nucleotide binding site [chemical binding]; other site 565034002131 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 565034002132 TRAM domain; Region: TRAM; pfam01938 565034002133 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034002134 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034002135 hypothetical protein; Provisional; Region: PRK01346 565034002136 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 565034002137 Sterol carrier protein domain; Region: SCP2_2; pfam13530 565034002138 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 565034002139 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034002140 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034002141 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034002142 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034002143 gamma-glutamyl kinase; Provisional; Region: PRK05429 565034002144 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 565034002145 nucleotide binding site [chemical binding]; other site 565034002146 homotetrameric interface [polypeptide binding]; other site 565034002147 putative phosphate binding site [ion binding]; other site 565034002148 putative allosteric binding site; other site 565034002149 PUA domain; Region: PUA; pfam01472 565034002150 ADP-glucose phosphorylase; Region: PLN02643 565034002151 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 565034002152 nucleotide binding site/active site [active] 565034002153 HIT family signature motif; other site 565034002154 catalytic residue [active] 565034002155 Response regulator receiver domain; Region: Response_reg; pfam00072 565034002156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034002157 active site 565034002158 phosphorylation site [posttranslational modification] 565034002159 intermolecular recognition site; other site 565034002160 dimerization interface [polypeptide binding]; other site 565034002161 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 565034002162 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 565034002163 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 565034002164 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 565034002165 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 565034002166 Peptidase family U32; Region: Peptidase_U32; pfam01136 565034002167 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 565034002168 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 565034002169 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 565034002170 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 565034002171 Walker A/P-loop; other site 565034002172 ATP binding site [chemical binding]; other site 565034002173 Q-loop/lid; other site 565034002174 ABC transporter signature motif; other site 565034002175 Walker B; other site 565034002176 D-loop; other site 565034002177 H-loop/switch region; other site 565034002178 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 565034002179 Ferritin-like domain; Region: Ferritin; pfam00210 565034002180 ferroxidase diiron center [ion binding]; other site 565034002181 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 565034002182 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 565034002183 cofactor binding site; other site 565034002184 DNA binding site [nucleotide binding] 565034002185 substrate interaction site [chemical binding]; other site 565034002186 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 565034002187 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 565034002188 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 565034002189 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 565034002190 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565034002191 ATP binding site [chemical binding]; other site 565034002192 putative Mg++ binding site [ion binding]; other site 565034002193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565034002194 nucleotide binding region [chemical binding]; other site 565034002195 ATP-binding site [chemical binding]; other site 565034002196 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 565034002197 nucleophile elbow; other site 565034002198 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 565034002199 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 565034002200 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 565034002201 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002202 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 565034002203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034002204 S-adenosylmethionine binding site [chemical binding]; other site 565034002205 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 565034002206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565034002207 Coenzyme A binding pocket [chemical binding]; other site 565034002208 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 565034002209 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 565034002210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034002211 dimer interface [polypeptide binding]; other site 565034002212 conserved gate region; other site 565034002213 putative PBP binding loops; other site 565034002214 ABC-ATPase subunit interface; other site 565034002215 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 565034002216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034002217 dimer interface [polypeptide binding]; other site 565034002218 conserved gate region; other site 565034002219 putative PBP binding loops; other site 565034002220 ABC-ATPase subunit interface; other site 565034002221 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 565034002222 RNA/DNA hybrid binding site [nucleotide binding]; other site 565034002223 active site 565034002224 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 565034002225 DHH family; Region: DHH; pfam01368 565034002226 DHHA1 domain; Region: DHHA1; pfam02272 565034002227 Ribosome-binding factor A; Region: RBFA; pfam02033 565034002228 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 565034002229 putative CheA interaction surface; other site 565034002230 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 565034002231 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565034002232 active site 565034002233 metal binding site [ion binding]; metal-binding site 565034002234 AAA domain; Region: AAA_23; pfam13476 565034002235 P-loop containing region of AAA domain; Region: AAA_29; cl17516 565034002236 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 565034002237 LabA_like proteins; Region: LabA_like; cd06167 565034002238 putative metal binding site [ion binding]; other site 565034002239 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 565034002240 prephenate dehydrogenase; Validated; Region: PRK08507 565034002241 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 565034002242 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 565034002243 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 565034002244 active site 565034002245 EamA-like transporter family; Region: EamA; pfam00892 565034002246 EamA-like transporter family; Region: EamA; pfam00892 565034002247 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 565034002248 23S rRNA binding site [nucleotide binding]; other site 565034002249 L21 binding site [polypeptide binding]; other site 565034002250 L13 binding site [polypeptide binding]; other site 565034002251 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 565034002252 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 565034002253 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 565034002254 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 565034002255 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 565034002256 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 565034002257 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 565034002258 active site 565034002259 dimer interface [polypeptide binding]; other site 565034002260 motif 1; other site 565034002261 motif 2; other site 565034002262 motif 3; other site 565034002263 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 565034002264 anticodon binding site; other site 565034002265 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034002266 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034002267 dimer interface [polypeptide binding]; other site 565034002268 putative CheW interface [polypeptide binding]; other site 565034002269 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 565034002270 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 565034002271 intersubunit interface [polypeptide binding]; other site 565034002272 active site 565034002273 zinc binding site [ion binding]; other site 565034002274 Na+ binding site [ion binding]; other site 565034002275 Uncharacterized conserved protein [Function unknown]; Region: COG1912 565034002276 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 565034002277 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034002278 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034002279 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034002280 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034002281 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 565034002282 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 565034002283 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 565034002284 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 565034002285 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 565034002286 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 565034002287 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 565034002288 Bifunctional nuclease; Region: DNase-RNase; pfam02577 565034002289 TPR repeat; Region: TPR_11; pfam13414 565034002290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002291 binding surface 565034002292 TPR motif; other site 565034002293 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 565034002294 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 565034002295 putative substrate binding site [chemical binding]; other site 565034002296 putative ATP binding site [chemical binding]; other site 565034002297 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 565034002298 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 565034002299 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 565034002300 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 565034002301 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034002302 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034002303 peptide binding site [polypeptide binding]; other site 565034002304 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 565034002305 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 565034002306 putative ligand binding site [chemical binding]; other site 565034002307 putative NAD binding site [chemical binding]; other site 565034002308 catalytic site [active] 565034002309 Tetratricopeptide repeat; Region: TPR_6; pfam13174 565034002310 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 565034002311 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 565034002312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565034002313 ATP binding site [chemical binding]; other site 565034002314 putative Mg++ binding site [ion binding]; other site 565034002315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565034002316 nucleotide binding region [chemical binding]; other site 565034002317 ATP-binding site [chemical binding]; other site 565034002318 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002319 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002320 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002321 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 565034002322 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002323 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002324 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 565034002325 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002326 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002327 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002328 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 565034002329 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034002330 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034002331 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002332 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 565034002333 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002334 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 565034002335 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002336 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 565034002337 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002338 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002339 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 565034002340 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 565034002341 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 565034002342 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 565034002343 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 565034002344 intersubunit interface [polypeptide binding]; other site 565034002345 active site 565034002346 Zn2+ binding site [ion binding]; other site 565034002347 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 565034002348 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 565034002349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002350 binding surface 565034002351 TPR motif; other site 565034002352 Tetratricopeptide repeat; Region: TPR_16; pfam13432 565034002353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002354 binding surface 565034002355 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034002356 TPR motif; other site 565034002357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002358 TPR motif; other site 565034002359 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034002360 binding surface 565034002361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034002362 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034002363 TPR motif; other site 565034002364 binding surface 565034002365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002366 binding surface 565034002367 TPR motif; other site 565034002368 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034002369 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 565034002370 FMN-binding domain; Region: FMN_bind; cl01081 565034002371 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 565034002372 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 565034002373 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 565034002374 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 565034002375 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 565034002376 oligomer interface [polypeptide binding]; other site 565034002377 tandem repeat interface [polypeptide binding]; other site 565034002378 active site residues [active] 565034002379 Predicted permeases [General function prediction only]; Region: COG0795 565034002380 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 565034002381 Cytochrome P450; Region: p450; cl12078 565034002382 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034002383 TPR repeat; Region: TPR_11; pfam13414 565034002384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002385 binding surface 565034002386 TPR motif; other site 565034002387 TPR repeat; Region: TPR_11; pfam13414 565034002388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002389 binding surface 565034002390 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034002391 TPR motif; other site 565034002392 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034002393 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 565034002394 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 565034002395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034002396 catalytic residue [active] 565034002397 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 565034002398 Catalytic site [active] 565034002399 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 565034002400 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 565034002401 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 565034002402 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 565034002403 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 565034002404 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 565034002405 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 565034002406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034002407 active site 565034002408 phosphorylation site [posttranslational modification] 565034002409 intermolecular recognition site; other site 565034002410 dimerization interface [polypeptide binding]; other site 565034002411 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 565034002412 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 565034002413 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 565034002414 MgtE intracellular N domain; Region: MgtE_N; cl15244 565034002415 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 565034002416 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 565034002417 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 565034002418 B12 binding site [chemical binding]; other site 565034002419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034002420 FeS/SAM binding site; other site 565034002421 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 565034002422 TPR repeat; Region: TPR_11; pfam13414 565034002423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002424 binding surface 565034002425 TPR motif; other site 565034002426 TPR repeat; Region: TPR_11; pfam13414 565034002427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002428 binding surface 565034002429 TPR motif; other site 565034002430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002431 binding surface 565034002432 TPR repeat; Region: TPR_11; pfam13414 565034002433 TPR motif; other site 565034002434 TPR repeat; Region: TPR_11; pfam13414 565034002435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002436 binding surface 565034002437 TPR motif; other site 565034002438 TPR repeat; Region: TPR_11; pfam13414 565034002439 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 565034002440 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 565034002441 Ligand binding site; other site 565034002442 Putative Catalytic site; other site 565034002443 DXD motif; other site 565034002444 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 565034002445 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 565034002446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034002447 FeS/SAM binding site; other site 565034002448 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 565034002449 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 565034002450 xylulokinase; Region: PLN02669 565034002451 nucleotide binding site [chemical binding]; other site 565034002452 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 565034002453 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 565034002454 Walker A/P-loop; other site 565034002455 ATP binding site [chemical binding]; other site 565034002456 Q-loop/lid; other site 565034002457 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 565034002458 ABC transporter signature motif; other site 565034002459 Walker B; other site 565034002460 D-loop; other site 565034002461 H-loop/switch region; other site 565034002462 ATP-NAD kinase; Region: NAD_kinase; pfam01513 565034002463 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 565034002464 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 565034002465 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 565034002466 putative acyl-acceptor binding pocket; other site 565034002467 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 565034002468 4Fe-4S binding domain; Region: Fer4_6; pfam12837 565034002469 4Fe-4S binding domain; Region: Fer4; pfam00037 565034002470 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 565034002471 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034002472 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034002473 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034002474 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 565034002475 Interdomain contacts; other site 565034002476 Cytokine receptor motif; other site 565034002477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034002478 binding surface 565034002479 TPR motif; other site 565034002480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034002481 binding surface 565034002482 TPR motif; other site 565034002483 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 565034002484 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565034002485 substrate binding pocket [chemical binding]; other site 565034002486 membrane-bound complex binding site; other site 565034002487 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 565034002488 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 565034002489 hinge; other site 565034002490 active site 565034002491 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 565034002492 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 565034002493 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 565034002494 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 565034002495 Rubrerythrin [Energy production and conversion]; Region: COG1592 565034002496 binuclear metal center [ion binding]; other site 565034002497 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 565034002498 iron binding site [ion binding]; other site 565034002499 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 565034002500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565034002501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034002502 homodimer interface [polypeptide binding]; other site 565034002503 catalytic residue [active] 565034002504 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 565034002505 TPR repeat; Region: TPR_11; pfam13414 565034002506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002507 binding surface 565034002508 TPR motif; other site 565034002509 imidazolonepropionase; Validated; Region: PRK09356 565034002510 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 565034002511 active site 565034002512 putative hydrolase; Validated; Region: PRK09248 565034002513 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 565034002514 active site 565034002515 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 565034002516 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 565034002517 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 565034002518 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 565034002519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034002520 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 565034002521 FeS/SAM binding site; other site 565034002522 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 565034002523 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 565034002524 metal binding site [ion binding]; metal-binding site 565034002525 dimer interface [polypeptide binding]; other site 565034002526 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 565034002527 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 565034002528 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 565034002529 catalytic residue [active] 565034002530 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 565034002531 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 565034002532 trimerization site [polypeptide binding]; other site 565034002533 active site 565034002534 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 565034002535 NifU-like domain; Region: NifU; cl00484 565034002536 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 565034002537 monogalactosyldiacylglycerol synthase; Region: PLN02605 565034002538 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 565034002539 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 565034002540 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 565034002541 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 565034002542 RNA binding site [nucleotide binding]; other site 565034002543 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 565034002544 RNA binding site [nucleotide binding]; other site 565034002545 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 565034002546 RNA binding site [nucleotide binding]; other site 565034002547 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 565034002548 RNA binding site [nucleotide binding]; other site 565034002549 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 565034002550 RNA binding site [nucleotide binding]; other site 565034002551 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 565034002552 RNA binding site [nucleotide binding]; other site 565034002553 cytidylate kinase; Provisional; Region: cmk; PRK00023 565034002554 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 565034002555 CMP-binding site; other site 565034002556 The sites determining sugar specificity; other site 565034002557 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034002558 active site 565034002559 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 565034002560 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 565034002561 dimer interface [polypeptide binding]; other site 565034002562 active site 565034002563 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034002564 active site 565034002565 potential frameshift: common BLAST hit: gi|120434912|ref|YP_860598.1| nucleotide-diphospho-sugar transferase domain-containing protein 565034002566 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034002567 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 565034002568 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 565034002569 Ligand binding site; other site 565034002570 metal-binding site 565034002571 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 565034002572 active site 565034002573 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034002574 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306 565034002575 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565034002576 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565034002577 active site 565034002578 catalytic tetrad [active] 565034002579 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 565034002580 Mechanosensitive ion channel; Region: MS_channel; pfam00924 565034002581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 565034002582 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 565034002583 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 565034002584 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 565034002585 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 565034002586 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 565034002587 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565034002588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034002589 homodimer interface [polypeptide binding]; other site 565034002590 catalytic residue [active] 565034002591 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 565034002592 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 565034002593 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 565034002594 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 565034002595 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 565034002596 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 565034002597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002598 binding surface 565034002599 TPR motif; other site 565034002600 TPR repeat; Region: TPR_11; pfam13414 565034002601 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 565034002602 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 565034002603 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 565034002604 active site 565034002605 catalytic residues [active] 565034002606 metal binding site [ion binding]; metal-binding site 565034002607 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 565034002608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034002609 motif II; other site 565034002610 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 565034002611 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565034002612 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565034002613 Peptidase family M23; Region: Peptidase_M23; pfam01551 565034002614 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 565034002615 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 565034002616 metal binding site [ion binding]; metal-binding site 565034002617 active site 565034002618 I-site; other site 565034002619 potassium/proton antiporter; Reviewed; Region: PRK05326 565034002620 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 565034002621 TrkA-C domain; Region: TrkA_C; pfam02080 565034002622 TrkA-C domain; Region: TrkA_C; pfam02080 565034002623 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 565034002624 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034002625 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034002626 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034002627 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034002628 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034002629 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034002630 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034002631 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034002632 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034002633 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 565034002634 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 565034002635 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 565034002636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565034002637 non-specific DNA binding site [nucleotide binding]; other site 565034002638 salt bridge; other site 565034002639 sequence-specific DNA binding site [nucleotide binding]; other site 565034002640 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 565034002641 MPN+ (JAMM) motif; other site 565034002642 Zinc-binding site [ion binding]; other site 565034002643 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 565034002644 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 565034002645 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 565034002646 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 565034002647 G1 box; other site 565034002648 G1 box; other site 565034002649 GTP/Mg2+ binding site [chemical binding]; other site 565034002650 GTP/Mg2+ binding site [chemical binding]; other site 565034002651 Switch I region; other site 565034002652 G2 box; other site 565034002653 G3 box; other site 565034002654 Switch II region; other site 565034002655 G4 box; other site 565034002656 G5 box; other site 565034002657 Nucleoside recognition; Region: Gate; pfam07670 565034002658 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 565034002659 Nucleoside recognition; Region: Gate; pfam07670 565034002660 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 565034002661 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 565034002662 EamA-like transporter family; Region: EamA; cl17759 565034002663 Flagellin N-methylase; Region: FliB; cl00497 565034002664 tellurium resistance terB-like protein; Region: terB_like; cl11965 565034002665 metal binding site [ion binding]; metal-binding site 565034002666 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 565034002667 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 565034002668 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 565034002669 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 565034002670 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 565034002671 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 565034002672 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 565034002673 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 565034002674 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 565034002675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034002676 Walker A/P-loop; other site 565034002677 ATP binding site [chemical binding]; other site 565034002678 Q-loop/lid; other site 565034002679 ABC transporter signature motif; other site 565034002680 Walker B; other site 565034002681 D-loop; other site 565034002682 H-loop/switch region; other site 565034002683 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 565034002684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034002685 dimer interface [polypeptide binding]; other site 565034002686 conserved gate region; other site 565034002687 putative PBP binding loops; other site 565034002688 ABC-ATPase subunit interface; other site 565034002689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034002690 dimer interface [polypeptide binding]; other site 565034002691 conserved gate region; other site 565034002692 putative PBP binding loops; other site 565034002693 ABC-ATPase subunit interface; other site 565034002694 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 565034002695 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 565034002696 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 565034002697 nucleotide binding region [chemical binding]; other site 565034002698 SEC-C motif; Region: SEC-C; pfam02810 565034002699 OstA-like protein; Region: OstA_2; pfam13100 565034002700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 565034002701 OstA-like protein; Region: OstA; cl00844 565034002702 OstA-like protein; Region: OstA; cl00844 565034002703 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 565034002704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034002705 active site 565034002706 motif I; other site 565034002707 motif II; other site 565034002708 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 565034002709 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 565034002710 dimerization interface 3.5A [polypeptide binding]; other site 565034002711 active site 565034002712 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 565034002713 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 565034002714 zinc binding site [ion binding]; other site 565034002715 putative ligand binding site [chemical binding]; other site 565034002716 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 565034002717 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 565034002718 inhibitor-cofactor binding pocket; inhibition site 565034002719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034002720 catalytic residue [active] 565034002721 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 565034002722 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 565034002723 ABC-ATPase subunit interface; other site 565034002724 dimer interface [polypeptide binding]; other site 565034002725 putative PBP binding regions; other site 565034002726 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 565034002727 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 565034002728 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 565034002729 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 565034002730 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 565034002731 intersubunit interface [polypeptide binding]; other site 565034002732 META domain; Region: META; pfam03724 565034002733 META domain; Region: META; pfam03724 565034002734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034002735 dimer interface [polypeptide binding]; other site 565034002736 conserved gate region; other site 565034002737 ABC-ATPase subunit interface; other site 565034002738 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565034002739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034002740 Walker A/P-loop; other site 565034002741 ATP binding site [chemical binding]; other site 565034002742 Q-loop/lid; other site 565034002743 ABC transporter signature motif; other site 565034002744 Walker B; other site 565034002745 D-loop; other site 565034002746 H-loop/switch region; other site 565034002747 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 565034002748 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 565034002749 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 565034002750 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 565034002751 CTP synthetase; Validated; Region: pyrG; PRK05380 565034002752 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 565034002753 Catalytic site [active] 565034002754 active site 565034002755 UTP binding site [chemical binding]; other site 565034002756 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 565034002757 active site 565034002758 putative oxyanion hole; other site 565034002759 catalytic triad [active] 565034002760 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 565034002761 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 565034002762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034002763 AAA domain; Region: AAA_21; pfam13304 565034002764 Walker A/P-loop; other site 565034002765 ATP binding site [chemical binding]; other site 565034002766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034002767 Walker B; other site 565034002768 D-loop; other site 565034002769 H-loop/switch region; other site 565034002770 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 565034002771 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 565034002772 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 565034002773 substrate binding site [chemical binding]; other site 565034002774 ATP binding site [chemical binding]; other site 565034002775 recombination protein RecR; Reviewed; Region: recR; PRK00076 565034002776 RecR protein; Region: RecR; pfam02132 565034002777 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 565034002778 putative active site [active] 565034002779 putative metal-binding site [ion binding]; other site 565034002780 tetramer interface [polypeptide binding]; other site 565034002781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 565034002782 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 565034002783 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 565034002784 classical (c) SDRs; Region: SDR_c; cd05233 565034002785 NAD(P) binding site [chemical binding]; other site 565034002786 active site 565034002787 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034002788 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 565034002789 MoxR-like ATPases [General function prediction only]; Region: COG0714 565034002790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034002791 Walker A motif; other site 565034002792 ATP binding site [chemical binding]; other site 565034002793 Walker B motif; other site 565034002794 arginine finger; other site 565034002795 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 565034002796 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 565034002797 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 565034002798 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 565034002799 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 565034002800 N-acetyl-D-glucosamine binding site [chemical binding]; other site 565034002801 catalytic residue [active] 565034002802 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 565034002803 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 565034002804 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 565034002805 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 565034002806 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 565034002807 tetramer interface [polypeptide binding]; other site 565034002808 heme binding pocket [chemical binding]; other site 565034002809 NADPH binding site [chemical binding]; other site 565034002810 ferrochelatase; Reviewed; Region: hemH; PRK00035 565034002811 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 565034002812 active site 565034002813 C-terminal domain interface [polypeptide binding]; other site 565034002814 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 565034002815 active site 565034002816 N-terminal domain interface [polypeptide binding]; other site 565034002817 Bacterial Ig-like domain; Region: Big_5; pfam13205 565034002818 Bacterial Ig-like domain; Region: Big_5; pfam13205 565034002819 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 565034002820 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 565034002821 MG2 domain; Region: A2M_N; pfam01835 565034002822 Alpha-2-macroglobulin family; Region: A2M; pfam00207 565034002823 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 565034002824 surface patch; other site 565034002825 thioester region; other site 565034002826 specificity defining residues; other site 565034002827 Predicted membrane protein [Function unknown]; Region: COG2364 565034002828 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 565034002829 FAD binding domain; Region: FAD_binding_4; pfam01565 565034002830 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 565034002831 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002832 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 565034002833 ScpA/B protein; Region: ScpA_ScpB; cl00598 565034002834 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 565034002835 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565034002836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 565034002837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565034002838 Coenzyme A binding pocket [chemical binding]; other site 565034002839 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 565034002840 RuvA N terminal domain; Region: RuvA_N; pfam01330 565034002841 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 565034002842 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 565034002843 metal-binding site [ion binding] 565034002844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565034002845 dimer interface [polypeptide binding]; other site 565034002846 phosphorylation site [posttranslational modification] 565034002847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565034002848 ATP binding site [chemical binding]; other site 565034002849 Mg2+ binding site [ion binding]; other site 565034002850 G-X-G motif; other site 565034002851 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565034002852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034002853 active site 565034002854 phosphorylation site [posttranslational modification] 565034002855 intermolecular recognition site; other site 565034002856 dimerization interface [polypeptide binding]; other site 565034002857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 565034002858 DNA binding site [nucleotide binding] 565034002859 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 565034002860 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 565034002861 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 565034002862 diaminopimelate decarboxylase; Region: lysA; TIGR01048 565034002863 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 565034002864 active site 565034002865 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 565034002866 substrate binding site [chemical binding]; other site 565034002867 catalytic residues [active] 565034002868 dimer interface [polypeptide binding]; other site 565034002869 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 565034002870 NodB motif; other site 565034002871 putative active site [active] 565034002872 putative catalytic site [active] 565034002873 Zn binding site [ion binding]; other site 565034002874 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565034002875 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 565034002876 active site 565034002877 metal binding site [ion binding]; metal-binding site 565034002878 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 565034002879 regulatory protein interface [polypeptide binding]; other site 565034002880 regulatory phosphorylation site [posttranslational modification]; other site 565034002881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565034002882 non-specific DNA binding site [nucleotide binding]; other site 565034002883 salt bridge; other site 565034002884 sequence-specific DNA binding site [nucleotide binding]; other site 565034002885 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 565034002886 G1 box; other site 565034002887 GTP/Mg2+ binding site [chemical binding]; other site 565034002888 G2 box; other site 565034002889 Switch I region; other site 565034002890 G3 box; other site 565034002891 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 565034002892 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 565034002893 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 565034002894 Phosphotransferase enzyme family; Region: APH; pfam01636 565034002895 aspartate aminotransferase; Provisional; Region: PRK07568 565034002896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565034002897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034002898 homodimer interface [polypeptide binding]; other site 565034002899 catalytic residue [active] 565034002900 aspartate aminotransferase; Provisional; Region: PRK07568 565034002901 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565034002902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034002903 homodimer interface [polypeptide binding]; other site 565034002904 catalytic residue [active] 565034002905 PEGA domain; Region: PEGA; pfam08308 565034002906 adenylate kinase; Reviewed; Region: adk; PRK00279 565034002907 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 565034002908 AMP-binding site [chemical binding]; other site 565034002909 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 565034002910 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 565034002911 putative RNA binding site [nucleotide binding]; other site 565034002912 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 565034002913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002914 binding surface 565034002915 TPR motif; other site 565034002916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002917 TPR motif; other site 565034002918 binding surface 565034002919 Tetratricopeptide repeat; Region: TPR_16; pfam13432 565034002920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002921 binding surface 565034002922 TPR motif; other site 565034002923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002924 TPR motif; other site 565034002925 binding surface 565034002926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002927 binding surface 565034002928 TPR motif; other site 565034002929 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 565034002930 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 565034002931 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 565034002932 active site 565034002933 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 565034002934 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 565034002935 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 565034002936 DNA repair protein RadA; Provisional; Region: PRK11823 565034002937 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 565034002938 Walker A motif; other site 565034002939 ATP binding site [chemical binding]; other site 565034002940 Walker B motif; other site 565034002941 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 565034002942 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 565034002943 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 565034002944 active site 565034002945 dimer interface [polypeptide binding]; other site 565034002946 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 565034002947 Domain of unknown function DUF21; Region: DUF21; pfam01595 565034002948 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 565034002949 Transporter associated domain; Region: CorC_HlyC; smart01091 565034002950 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 565034002951 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 565034002952 Ligand Binding Site [chemical binding]; other site 565034002953 Sporulation related domain; Region: SPOR; pfam05036 565034002954 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 565034002955 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 565034002956 CoA-binding site [chemical binding]; other site 565034002957 ATP-binding [chemical binding]; other site 565034002958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002959 binding surface 565034002960 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 565034002961 TPR motif; other site 565034002962 cell division protein FtsZ; Validated; Region: PRK09330 565034002963 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 565034002964 nucleotide binding site [chemical binding]; other site 565034002965 SulA interaction site; other site 565034002966 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 565034002967 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 565034002968 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034002969 FeS/SAM binding site; other site 565034002970 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002971 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034002972 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 565034002973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002974 binding surface 565034002975 TPR repeat; Region: TPR_11; pfam13414 565034002976 TPR motif; other site 565034002977 TPR repeat; Region: TPR_11; pfam13414 565034002978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002979 binding surface 565034002980 TPR motif; other site 565034002981 TPR repeat; Region: TPR_11; pfam13414 565034002982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002983 binding surface 565034002984 TPR motif; other site 565034002985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002986 binding surface 565034002987 TPR motif; other site 565034002988 TPR repeat; Region: TPR_11; pfam13414 565034002989 TPR repeat; Region: TPR_11; pfam13414 565034002990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034002991 binding surface 565034002992 TPR motif; other site 565034002993 TPR repeat; Region: TPR_11; pfam13414 565034002994 TPR repeat; Region: TPR_11; pfam13414 565034002995 potential frameshift: common BLAST hit: gi|190150179|ref|YP_001968704.1| FAD flavoprotein oxidase 565034002996 L-aspartate oxidase; Provisional; Region: PRK06175 565034002997 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 565034002998 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 565034002999 L-aspartate oxidase; Provisional; Region: PRK06175 565034003000 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 565034003001 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 565034003002 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 565034003003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565034003004 Coenzyme A binding pocket [chemical binding]; other site 565034003005 ferredoxin; Provisional; Region: PRK08764 565034003006 Putative Fe-S cluster; Region: FeS; cl17515 565034003007 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 565034003008 electron transport complex RsxE subunit; Provisional; Region: PRK12405 565034003009 Cache domain; Region: Cache_1; pfam02743 565034003010 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 565034003011 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034003012 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034003013 dimer interface [polypeptide binding]; other site 565034003014 putative CheW interface [polypeptide binding]; other site 565034003015 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034003016 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003017 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003018 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003019 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003020 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003021 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 565034003022 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003023 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003024 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003025 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003026 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003027 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003028 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003029 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003030 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003031 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003032 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003033 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003034 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034003035 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003036 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003037 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003038 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003039 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003040 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 565034003041 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 565034003042 flagellin; Provisional; Region: PRK12804 565034003043 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 565034003044 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 565034003045 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 565034003046 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 565034003047 DNA binding residues [nucleotide binding] 565034003048 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 565034003049 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 565034003050 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 565034003051 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 565034003052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 565034003053 DNA binding residues [nucleotide binding] 565034003054 DNA primase, catalytic core; Region: dnaG; TIGR01391 565034003055 CHC2 zinc finger; Region: zf-CHC2; cl17510 565034003056 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 565034003057 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 565034003058 active site 565034003059 metal binding site [ion binding]; metal-binding site 565034003060 interdomain interaction site; other site 565034003061 60S ribosomal protein L37a; Provisional; Region: PTZ00255; cl00875 565034003062 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 565034003063 nudix motif; other site 565034003064 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 565034003065 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 565034003066 Catalytic site [active] 565034003067 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 565034003068 AzlC protein; Region: AzlC; cl00570 565034003069 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 565034003070 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034003071 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034003072 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 565034003073 dimer interface [polypeptide binding]; other site 565034003074 catalytic residues [active] 565034003075 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 565034003076 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 565034003077 dimer interface [polypeptide binding]; other site 565034003078 catalytic triad [active] 565034003079 peroxidatic and resolving cysteines [active] 565034003080 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 565034003081 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 565034003082 active site 565034003083 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 565034003084 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 565034003085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034003086 active site 565034003087 phosphorylation site [posttranslational modification] 565034003088 intermolecular recognition site; other site 565034003089 dimerization interface [polypeptide binding]; other site 565034003090 DNA gyrase subunit A; Validated; Region: PRK05560 565034003091 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 565034003092 CAP-like domain; other site 565034003093 active site 565034003094 primary dimer interface [polypeptide binding]; other site 565034003095 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565034003096 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565034003097 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565034003098 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565034003099 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565034003100 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034003101 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565034003102 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565034003103 Walker A/P-loop; other site 565034003104 ATP binding site [chemical binding]; other site 565034003105 Q-loop/lid; other site 565034003106 ABC transporter signature motif; other site 565034003107 Walker B; other site 565034003108 D-loop; other site 565034003109 H-loop/switch region; other site 565034003110 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 565034003111 DEAD-like helicases superfamily; Region: DEXDc; smart00487 565034003112 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565034003113 ATP binding site [chemical binding]; other site 565034003114 putative Mg++ binding site [ion binding]; other site 565034003115 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565034003116 nucleotide binding region [chemical binding]; other site 565034003117 ATP-binding site [chemical binding]; other site 565034003118 TRCF domain; Region: TRCF; pfam03461 565034003119 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 565034003120 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 565034003121 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 565034003122 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 565034003123 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 565034003124 putative substrate binding site [chemical binding]; other site 565034003125 putative ATP binding site [chemical binding]; other site 565034003126 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 565034003127 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565034003128 active site 565034003129 phosphorylation site [posttranslational modification] 565034003130 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 565034003131 active site 565034003132 P-loop; other site 565034003133 phosphorylation site [posttranslational modification] 565034003134 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 565034003135 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034003136 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034003137 peptide binding site [polypeptide binding]; other site 565034003138 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034003139 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034003140 peptide binding site [polypeptide binding]; other site 565034003141 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034003142 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034003143 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034003144 dimer interface [polypeptide binding]; other site 565034003145 putative CheW interface [polypeptide binding]; other site 565034003146 Cache domain; Region: Cache_1; pfam02743 565034003147 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034003148 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034003149 dimer interface [polypeptide binding]; other site 565034003150 putative CheW interface [polypeptide binding]; other site 565034003151 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034003152 dimer interface [polypeptide binding]; other site 565034003153 putative CheW interface [polypeptide binding]; other site 565034003154 Cache domain; Region: Cache_1; pfam02743 565034003155 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 565034003156 putative efflux protein, MATE family; Region: matE; TIGR00797 565034003157 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 565034003158 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 565034003159 active site 565034003160 metal binding site [ion binding]; metal-binding site 565034003161 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 565034003162 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 565034003163 active site residue [active] 565034003164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034003165 Walker A/P-loop; other site 565034003166 ATP binding site [chemical binding]; other site 565034003167 AAA ATPase domain; Region: AAA_15; pfam13175 565034003168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034003169 Walker B; other site 565034003170 D-loop; other site 565034003171 H-loop/switch region; other site 565034003172 Helix-turn-helix domain; Region: HTH_17; cl17695 565034003173 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 565034003174 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 565034003175 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 565034003176 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 565034003177 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 565034003178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 565034003179 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cl00540 565034003180 tetramerization interface [polypeptide binding]; other site 565034003181 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 565034003182 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 565034003183 SirA-like protein; Region: SirA; pfam01206 565034003184 CPxP motif; other site 565034003185 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 565034003186 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 565034003187 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 565034003188 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 565034003189 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 565034003190 dimer interface [polypeptide binding]; other site 565034003191 ssDNA binding site [nucleotide binding]; other site 565034003192 tetramer (dimer of dimers) interface [polypeptide binding]; other site 565034003193 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 565034003194 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 565034003195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565034003196 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 565034003197 putative substrate translocation pore; other site 565034003198 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 565034003199 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 565034003200 catalytic residues [active] 565034003201 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 565034003202 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034003203 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003204 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 565034003205 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 565034003206 active site 2 [active] 565034003207 active site 1 [active] 565034003208 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 565034003209 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 565034003210 tartrate dehydrogenase; Region: TTC; TIGR02089 565034003211 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 565034003212 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 565034003213 substrate binding site [chemical binding]; other site 565034003214 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 565034003215 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 565034003216 substrate binding site [chemical binding]; other site 565034003217 ligand binding site [chemical binding]; other site 565034003218 2-isopropylmalate synthase; Validated; Region: PRK00915 565034003219 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 565034003220 active site 565034003221 catalytic residues [active] 565034003222 metal binding site [ion binding]; metal-binding site 565034003223 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 565034003224 ketol-acid reductoisomerase; Provisional; Region: PRK05479 565034003225 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 565034003226 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 565034003227 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 565034003228 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 565034003229 putative valine binding site [chemical binding]; other site 565034003230 dimer interface [polypeptide binding]; other site 565034003231 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 565034003232 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527 565034003233 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 565034003234 PYR/PP interface [polypeptide binding]; other site 565034003235 dimer interface [polypeptide binding]; other site 565034003236 TPP binding site [chemical binding]; other site 565034003237 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 565034003238 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 565034003239 TPP-binding site [chemical binding]; other site 565034003240 dimer interface [polypeptide binding]; other site 565034003241 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 565034003242 putative active site [active] 565034003243 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 565034003244 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 565034003245 active site 565034003246 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 565034003247 active site 565034003248 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565034003249 META domain; Region: META; pfam03724 565034003250 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003251 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003252 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003253 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034003254 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034003255 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003256 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003257 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003258 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003259 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034003260 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003261 GTPase RsgA; Reviewed; Region: PRK01889 565034003262 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 565034003263 RNA binding site [nucleotide binding]; other site 565034003264 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 565034003265 GTPase/Zn-binding domain interface [polypeptide binding]; other site 565034003266 GTP/Mg2+ binding site [chemical binding]; other site 565034003267 G4 box; other site 565034003268 G5 box; other site 565034003269 G1 box; other site 565034003270 Switch I region; other site 565034003271 G2 box; other site 565034003272 G3 box; other site 565034003273 Switch II region; other site 565034003274 DHHW protein; Region: DHHW; pfam14286 565034003275 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 565034003276 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 565034003277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565034003278 putative substrate translocation pore; other site 565034003279 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 565034003280 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565034003281 Soluble P-type ATPase [General function prediction only]; Region: COG4087 565034003282 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 565034003283 dimerization interface [polypeptide binding]; other site 565034003284 putative DNA binding site [nucleotide binding]; other site 565034003285 putative Zn2+ binding site [ion binding]; other site 565034003286 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 565034003287 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 565034003288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034003289 S-adenosylmethionine binding site [chemical binding]; other site 565034003290 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 565034003291 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 565034003292 putative catalytic cysteine [active] 565034003293 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 565034003294 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565034003295 active site turn [active] 565034003296 phosphorylation site [posttranslational modification] 565034003297 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565034003298 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 565034003299 beta-galactosidase; Region: BGL; TIGR03356 565034003300 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 565034003301 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 565034003302 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 565034003303 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 565034003304 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 565034003305 P-loop; other site 565034003306 Magnesium ion binding site [ion binding]; other site 565034003307 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 565034003308 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 565034003309 Magnesium ion binding site [ion binding]; other site 565034003310 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 565034003311 ParB-like nuclease domain; Region: ParB; smart00470 565034003312 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 565034003313 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 565034003314 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 565034003315 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565034003316 putative active site [active] 565034003317 metal binding site [ion binding]; metal-binding site 565034003318 homodimer binding site [polypeptide binding]; other site 565034003319 phosphodiesterase; Provisional; Region: PRK12704 565034003320 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565034003321 Zn2+ binding site [ion binding]; other site 565034003322 Mg2+ binding site [ion binding]; other site 565034003323 Rubrerythrin [Energy production and conversion]; Region: COG1592 565034003324 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 565034003325 binuclear metal center [ion binding]; other site 565034003326 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 565034003327 iron binding site [ion binding]; other site 565034003328 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 565034003329 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 565034003330 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 565034003331 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 565034003332 Cl- selectivity filter; other site 565034003333 Cl- binding residues [ion binding]; other site 565034003334 pore gating glutamate residue; other site 565034003335 dimer interface [polypeptide binding]; other site 565034003336 H+/Cl- coupling transport residue; other site 565034003337 GTP-binding protein YchF; Reviewed; Region: PRK09601 565034003338 YchF GTPase; Region: YchF; cd01900 565034003339 G1 box; other site 565034003340 GTP/Mg2+ binding site [chemical binding]; other site 565034003341 Switch I region; other site 565034003342 G2 box; other site 565034003343 Switch II region; other site 565034003344 G3 box; other site 565034003345 G4 box; other site 565034003346 G5 box; other site 565034003347 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 565034003348 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 565034003349 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 565034003350 iron-sulfur cluster [ion binding]; other site 565034003351 [2Fe-2S] cluster binding site [ion binding]; other site 565034003352 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 565034003353 hydrophobic ligand binding site; other site 565034003354 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 565034003355 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 565034003356 active site 565034003357 Riboflavin kinase; Region: Flavokinase; smart00904 565034003358 S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic...; Region: S15_NS1_EPRS_RNA-bind; cl00349 565034003359 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 565034003360 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 565034003361 RNase E interface [polypeptide binding]; other site 565034003362 trimer interface [polypeptide binding]; other site 565034003363 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 565034003364 RNase E interface [polypeptide binding]; other site 565034003365 trimer interface [polypeptide binding]; other site 565034003366 active site 565034003367 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 565034003368 putative nucleic acid binding region [nucleotide binding]; other site 565034003369 G-X-X-G motif; other site 565034003370 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 565034003371 RNA binding site [nucleotide binding]; other site 565034003372 domain interface; other site 565034003373 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003374 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034003375 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003376 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003377 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003378 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003379 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 565034003380 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034003381 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 565034003382 active site 565034003383 substrate-binding site [chemical binding]; other site 565034003384 metal-binding site [ion binding] 565034003385 GTP binding site [chemical binding]; other site 565034003386 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034003387 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034003388 peptide binding site [polypeptide binding]; other site 565034003389 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 565034003390 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 565034003391 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 565034003392 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 565034003393 catalytic triad [active] 565034003394 recombinase A; Provisional; Region: recA; PRK09354 565034003395 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 565034003396 hexamer interface [polypeptide binding]; other site 565034003397 Walker A motif; other site 565034003398 ATP binding site [chemical binding]; other site 565034003399 Walker B motif; other site 565034003400 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 565034003401 Transcriptional regulator [Transcription]; Region: LytR; COG1316 565034003402 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 565034003403 potential frameshift: common BLAST hit: gi|189500024|ref|YP_001959494.1| peptide methionine sulfoxide reductase 565034003404 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 565034003405 methionine sulfoxide reductase B; Provisional; Region: PRK05508 565034003406 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 565034003407 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 565034003408 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565034003409 putative active site [active] 565034003410 putative metal binding site [ion binding]; other site 565034003411 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 565034003412 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 565034003413 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 565034003414 dimer interface [polypeptide binding]; other site 565034003415 putative anticodon binding site; other site 565034003416 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 565034003417 motif 1; other site 565034003418 active site 565034003419 motif 2; other site 565034003420 motif 3; other site 565034003421 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 565034003422 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003423 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003424 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034003425 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003426 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003427 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003428 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003429 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003430 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003431 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003432 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003433 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003434 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003435 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003436 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003437 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034003438 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034003439 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 565034003440 MutS domain I; Region: MutS_I; pfam01624 565034003441 MutS domain II; Region: MutS_II; pfam05188 565034003442 MutS domain III; Region: MutS_III; pfam05192 565034003443 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 565034003444 Walker A/P-loop; other site 565034003445 ATP binding site [chemical binding]; other site 565034003446 Q-loop/lid; other site 565034003447 ABC transporter signature motif; other site 565034003448 Walker B; other site 565034003449 D-loop; other site 565034003450 H-loop/switch region; other site 565034003451 Cupin domain; Region: Cupin_2; pfam07883 565034003452 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 565034003453 trimer interface [polypeptide binding]; other site 565034003454 active site 565034003455 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 565034003456 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 565034003457 active site 565034003458 dimer interface [polypeptide binding]; other site 565034003459 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 565034003460 dimer interface [polypeptide binding]; other site 565034003461 active site 565034003462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034003463 S-adenosylmethionine binding site [chemical binding]; other site 565034003464 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 565034003465 metal ion-dependent adhesion site (MIDAS); other site 565034003466 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 565034003467 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 565034003468 active site 565034003469 alpha-galactosidase; Provisional; Region: PRK15076 565034003470 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 565034003471 NAD(P) binding site [chemical binding]; other site 565034003472 LDH/MDH dimer interface [polypeptide binding]; other site 565034003473 substrate binding site [chemical binding]; other site 565034003474 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 565034003475 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 565034003476 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 565034003477 active site 565034003478 catalytic site [active] 565034003479 homodimer interface [polypeptide binding]; other site 565034003480 Lid 1; other site 565034003481 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 565034003482 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 565034003483 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 565034003484 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 565034003485 glutaminase active site [active] 565034003486 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 565034003487 dimer interface [polypeptide binding]; other site 565034003488 active site 565034003489 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 565034003490 dimer interface [polypeptide binding]; other site 565034003491 active site 565034003492 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 565034003493 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565034003494 Zn2+ binding site [ion binding]; other site 565034003495 Mg2+ binding site [ion binding]; other site 565034003496 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 565034003497 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 565034003498 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 565034003499 amidophosphoribosyltransferase; Provisional; Region: PRK05793 565034003500 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 565034003501 active site 565034003502 tetramer interface [polypeptide binding]; other site 565034003503 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565034003504 active site 565034003505 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 565034003506 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 565034003507 ATP binding site [chemical binding]; other site 565034003508 active site 565034003509 substrate binding site [chemical binding]; other site 565034003510 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 565034003511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034003512 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 565034003513 Walker A motif; other site 565034003514 ATP binding site [chemical binding]; other site 565034003515 Walker B motif; other site 565034003516 arginine finger; other site 565034003517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 565034003518 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034003519 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034003520 dimer interface [polypeptide binding]; other site 565034003521 putative CheW interface [polypeptide binding]; other site 565034003522 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 565034003523 dimer interface [polypeptide binding]; other site 565034003524 motif 1; other site 565034003525 active site 565034003526 motif 2; other site 565034003527 motif 3; other site 565034003528 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 565034003529 dinuclear metal binding motif [ion binding]; other site 565034003530 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 565034003531 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306 565034003532 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034003533 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 565034003534 Part of AAA domain; Region: AAA_19; pfam13245 565034003535 Family description; Region: UvrD_C_2; pfam13538 565034003536 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 565034003537 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 565034003538 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 565034003539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034003540 binding surface 565034003541 TPR motif; other site 565034003542 TPR repeat; Region: TPR_11; pfam13414 565034003543 Uncharacterized conserved protein [Function unknown]; Region: COG1624 565034003544 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 565034003545 YbbR-like protein; Region: YbbR; pfam07949 565034003546 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 565034003547 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 565034003548 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 565034003549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034003550 TPR motif; other site 565034003551 binding surface 565034003552 Domain of unknown function (DUF368); Region: DUF368; pfam04018 565034003553 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 565034003554 homotrimer interaction site [polypeptide binding]; other site 565034003555 putative active site [active] 565034003556 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 565034003557 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 565034003558 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 565034003559 shikimate binding site; other site 565034003560 NAD(P) binding site [chemical binding]; other site 565034003561 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 565034003562 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 565034003563 active site 565034003564 catalytic residue [active] 565034003565 dimer interface [polypeptide binding]; other site 565034003566 Leucine rich repeat; Region: LRR_8; pfam13855 565034003567 Leucine-rich repeats, typical (most populated) subfamily; Region: LRR_TYP; cl15310 565034003568 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565034003569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565034003570 substrate binding pocket [chemical binding]; other site 565034003571 membrane-bound complex binding site; other site 565034003572 hinge residues; other site 565034003573 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565034003574 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565034003575 substrate binding pocket [chemical binding]; other site 565034003576 membrane-bound complex binding site; other site 565034003577 hinge residues; other site 565034003578 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 565034003579 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 565034003580 Walker A/P-loop; other site 565034003581 ATP binding site [chemical binding]; other site 565034003582 Q-loop/lid; other site 565034003583 ABC transporter signature motif; other site 565034003584 Walker B; other site 565034003585 D-loop; other site 565034003586 H-loop/switch region; other site 565034003587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034003588 dimer interface [polypeptide binding]; other site 565034003589 conserved gate region; other site 565034003590 putative PBP binding loops; other site 565034003591 ABC-ATPase subunit interface; other site 565034003592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565034003593 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 565034003594 NAD(P) binding site [chemical binding]; other site 565034003595 active site 565034003596 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 565034003597 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 565034003598 active site 565034003599 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 565034003600 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034003601 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 565034003602 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 565034003603 dimerization interface [polypeptide binding]; other site 565034003604 putative ATP binding site [chemical binding]; other site 565034003605 pyruvate phosphate dikinase; Provisional; Region: PRK09279 565034003606 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 565034003607 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 565034003608 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 565034003609 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 565034003610 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 565034003611 ligand binding site [chemical binding]; other site 565034003612 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 565034003613 Na2 binding site [ion binding]; other site 565034003614 putative substrate binding site 1 [chemical binding]; other site 565034003615 Na binding site 1 [ion binding]; other site 565034003616 putative substrate binding site 2 [chemical binding]; other site 565034003617 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 565034003618 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 565034003619 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 565034003620 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 565034003621 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 565034003622 putative FMN binding site [chemical binding]; other site 565034003623 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856 565034003624 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003625 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003626 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 565034003627 Protein of unknown function (DUF464); Region: DUF464; pfam04327 565034003628 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 565034003629 FecR protein; Region: FecR; pfam04773 565034003630 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 565034003631 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 565034003632 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 565034003633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034003634 FeS/SAM binding site; other site 565034003635 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 565034003636 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 565034003637 active site 565034003638 (T/H)XGH motif; other site 565034003639 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 565034003640 active site 565034003641 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 565034003642 gamma subunit interface [polypeptide binding]; other site 565034003643 epsilon subunit interface [polypeptide binding]; other site 565034003644 LBP interface [polypeptide binding]; other site 565034003645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034003646 binding surface 565034003647 TPR motif; other site 565034003648 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 565034003649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034003650 TPR motif; other site 565034003651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034003652 binding surface 565034003653 binding surface 565034003654 TPR motif; other site 565034003655 DNA methylase; Region: N6_N4_Mtase; cl17433 565034003656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034003657 S-adenosylmethionine binding site [chemical binding]; other site 565034003658 DNA methylase; Region: N6_N4_Mtase; cl17433 565034003659 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 565034003660 Uncharacterized conserved protein [Function unknown]; Region: COG3937 565034003661 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 565034003662 ABC1 family; Region: ABC1; cl17513 565034003663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 565034003664 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 565034003665 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 565034003666 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 565034003667 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 565034003668 Class I aldolases; Region: Aldolase_Class_I; cl17187 565034003669 catalytic residue [active] 565034003670 putative oxidoreductase; Provisional; Region: PRK12831 565034003671 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 565034003672 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565034003673 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565034003674 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 565034003675 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 565034003676 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 565034003677 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 565034003678 Clp amino terminal domain; Region: Clp_N; pfam02861 565034003679 Clp amino terminal domain; Region: Clp_N; pfam02861 565034003680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034003681 Walker A motif; other site 565034003682 ATP binding site [chemical binding]; other site 565034003683 Walker B motif; other site 565034003684 arginine finger; other site 565034003685 UvrB/uvrC motif; Region: UVR; pfam02151 565034003686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034003687 Walker A motif; other site 565034003688 ATP binding site [chemical binding]; other site 565034003689 Walker B motif; other site 565034003690 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 565034003691 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 565034003692 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 565034003693 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 565034003694 DNA binding residues [nucleotide binding] 565034003695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034003696 Walker A motif; other site 565034003697 ATP binding site [chemical binding]; other site 565034003698 Walker B motif; other site 565034003699 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 565034003700 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 565034003701 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 565034003702 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034003703 FeS/SAM binding site; other site 565034003704 Helix-turn-helix domain; Region: HTH_25; pfam13413 565034003705 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 565034003706 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 565034003707 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 565034003708 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 565034003709 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 565034003710 active site residue [active] 565034003711 EamA-like transporter family; Region: EamA; pfam00892 565034003712 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 565034003713 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 565034003714 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 565034003715 minor groove reading motif; other site 565034003716 helix-hairpin-helix signature motif; other site 565034003717 substrate binding pocket [chemical binding]; other site 565034003718 active site 565034003719 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 565034003720 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 565034003721 triosephosphate isomerase; Provisional; Region: PRK14567 565034003722 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 565034003723 substrate binding site [chemical binding]; other site 565034003724 dimer interface [polypeptide binding]; other site 565034003725 catalytic triad [active] 565034003726 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 565034003727 Isochorismatase family; Region: Isochorismatase; pfam00857 565034003728 catalytic triad [active] 565034003729 dimer interface [polypeptide binding]; other site 565034003730 conserved cis-peptide bond; other site 565034003731 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 565034003732 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 565034003733 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 565034003734 active site 565034003735 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 565034003736 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 565034003737 active site 565034003738 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 565034003739 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 565034003740 putative active site [active] 565034003741 cell division protein FtsA; Region: ftsA; TIGR01174 565034003742 Cell division protein FtsA; Region: FtsA; smart00842 565034003743 Cell division protein FtsA; Region: FtsA; pfam14450 565034003744 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 565034003745 Domain of unknown function (DUF368); Region: DUF368; pfam04018 565034003746 DNA polymerase III subunit beta; Validated; Region: PRK05643 565034003747 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 565034003748 putative DNA binding surface [nucleotide binding]; other site 565034003749 dimer interface [polypeptide binding]; other site 565034003750 beta-clamp/clamp loader binding surface; other site 565034003751 beta-clamp/translesion DNA polymerase binding surface; other site 565034003752 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034003753 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034003754 Trp repressor protein; Region: Trp_repressor; cl17266 565034003755 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 565034003756 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 565034003757 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 565034003758 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 565034003759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 565034003760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 565034003761 DNA binding residues [nucleotide binding] 565034003762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034003763 active site 565034003764 phosphorylation site [posttranslational modification] 565034003765 intermolecular recognition site; other site 565034003766 dimerization interface [polypeptide binding]; other site 565034003767 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 565034003768 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 565034003769 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 565034003770 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 565034003771 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 565034003772 Alkaline phosphatase homologues; Region: alkPPc; smart00098 565034003773 active site 565034003774 dimer interface [polypeptide binding]; other site 565034003775 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 565034003776 dimer interface [polypeptide binding]; other site 565034003777 substrate binding site [chemical binding]; other site 565034003778 ATP binding site [chemical binding]; other site 565034003779 Response regulator receiver domain; Region: Response_reg; pfam00072 565034003780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034003781 active site 565034003782 phosphorylation site [posttranslational modification] 565034003783 dimerization interface [polypeptide binding]; other site 565034003784 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 565034003785 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 565034003786 active site 565034003787 catalytic site [active] 565034003788 GAF domain; Region: GAF_3; pfam13492 565034003789 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 565034003790 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 565034003791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565034003792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 565034003793 dimer interface [polypeptide binding]; other site 565034003794 phosphorylation site [posttranslational modification] 565034003795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565034003796 ATP binding site [chemical binding]; other site 565034003797 Mg2+ binding site [ion binding]; other site 565034003798 G-X-G motif; other site 565034003799 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 565034003800 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 565034003801 dimer interface [polypeptide binding]; other site 565034003802 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 565034003803 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 565034003804 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034003805 dimerization interface [polypeptide binding]; other site 565034003806 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034003807 dimer interface [polypeptide binding]; other site 565034003808 putative CheW interface [polypeptide binding]; other site 565034003809 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034003810 dimerization interface [polypeptide binding]; other site 565034003811 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034003812 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034003813 dimer interface [polypeptide binding]; other site 565034003814 putative CheW interface [polypeptide binding]; other site 565034003815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034003816 dimerization interface [polypeptide binding]; other site 565034003817 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034003818 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034003819 dimer interface [polypeptide binding]; other site 565034003820 putative CheW interface [polypeptide binding]; other site 565034003821 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 565034003822 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 565034003823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034003824 TPR motif; other site 565034003825 TPR repeat; Region: TPR_11; pfam13414 565034003826 binding surface 565034003827 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034003828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034003829 binding surface 565034003830 TPR motif; other site 565034003831 TPR repeat; Region: TPR_11; pfam13414 565034003832 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 565034003833 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 565034003834 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 565034003835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034003836 binding surface 565034003837 TPR motif; other site 565034003838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034003839 TPR motif; other site 565034003840 binding surface 565034003841 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 565034003842 substrate binding pocket [chemical binding]; other site 565034003843 substrate-Mg2+ binding site; other site 565034003844 aspartate-rich region 1; other site 565034003845 aspartate-rich region 2; other site 565034003846 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 565034003847 homotrimer interaction site [polypeptide binding]; other site 565034003848 zinc binding site [ion binding]; other site 565034003849 CDP-binding sites; other site 565034003850 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 565034003851 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 565034003852 PBP superfamily domain; Region: PBP_like_2; cl17296 565034003853 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 565034003854 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 565034003855 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 565034003856 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 565034003857 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 565034003858 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034003859 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 565034003860 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 565034003861 substrate binding pocket [chemical binding]; other site 565034003862 chain length determination region; other site 565034003863 substrate-Mg2+ binding site; other site 565034003864 catalytic residues [active] 565034003865 aspartate-rich region 1; other site 565034003866 active site lid residues [active] 565034003867 aspartate-rich region 2; other site 565034003868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 565034003869 Cache domain; Region: Cache_1; pfam02743 565034003870 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034003871 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034003872 dimer interface [polypeptide binding]; other site 565034003873 putative CheW interface [polypeptide binding]; other site 565034003874 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 565034003875 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 565034003876 B3/4 domain; Region: B3_4; pfam03483 565034003877 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 565034003878 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565034003879 Zn2+ binding site [ion binding]; other site 565034003880 Mg2+ binding site [ion binding]; other site 565034003881 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 565034003882 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 565034003883 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 565034003884 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 565034003885 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 565034003886 Protein of unknown function (DUF489); Region: DUF489; cl01097 565034003887 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 565034003888 Domain of unknown function DUF87; Region: DUF87; pfam01935 565034003889 HerA helicase [Replication, recombination, and repair]; Region: COG0433 565034003890 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 565034003891 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 565034003892 Domain of unknown function (DUF4209); Region: DUF4209; pfam13910 565034003893 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 565034003894 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 565034003895 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 565034003896 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 565034003897 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 565034003898 ADP-ribose binding site [chemical binding]; other site 565034003899 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 565034003900 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565034003901 active site 565034003902 HIGH motif; other site 565034003903 nucleotide binding site [chemical binding]; other site 565034003904 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 565034003905 active site 565034003906 KMSKS motif; other site 565034003907 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 565034003908 tRNA binding surface [nucleotide binding]; other site 565034003909 anticodon binding site; other site 565034003910 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 565034003911 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034003912 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 565034003913 Bax inhibitor 1 like; Region: BaxI_1; cl17691 565034003914 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 565034003915 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 565034003916 Response regulator receiver domain; Region: Response_reg; pfam00072 565034003917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034003918 active site 565034003919 phosphorylation site [posttranslational modification] 565034003920 intermolecular recognition site; other site 565034003921 dimerization interface [polypeptide binding]; other site 565034003922 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 565034003923 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 565034003924 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 565034003925 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 565034003926 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 565034003927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034003928 binding surface 565034003929 TPR motif; other site 565034003930 TPR repeat; Region: TPR_11; pfam13414 565034003931 rod shape-determining protein MreB; Provisional; Region: PRK13927 565034003932 MreB and similar proteins; Region: MreB_like; cd10225 565034003933 nucleotide binding site [chemical binding]; other site 565034003934 Mg binding site [ion binding]; other site 565034003935 putative protofilament interaction site [polypeptide binding]; other site 565034003936 RodZ interaction site [polypeptide binding]; other site 565034003937 rod shape-determining protein MreC; Provisional; Region: PRK13922 565034003938 rod shape-determining protein MreC; Region: MreC; pfam04085 565034003939 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 565034003940 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 565034003941 putative active site; other site 565034003942 putative metal binding residues [ion binding]; other site 565034003943 signature motif; other site 565034003944 putative triphosphate binding site [ion binding]; other site 565034003945 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 565034003946 NlpC/P60 family; Region: NLPC_P60; cl17555 565034003947 NlpC/P60 family; Region: NLPC_P60; cl17555 565034003948 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 565034003949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034003950 Walker A motif; other site 565034003951 ATP binding site [chemical binding]; other site 565034003952 Walker B motif; other site 565034003953 arginine finger; other site 565034003954 Peptidase family M41; Region: Peptidase_M41; pfam01434 565034003955 Predicted transcriptional regulators [Transcription]; Region: COG1733 565034003956 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 565034003957 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 565034003958 classical (c) SDRs; Region: SDR_c; cd05233 565034003959 NAD(P) binding site [chemical binding]; other site 565034003960 active site 565034003961 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 565034003962 putative active site pocket [active] 565034003963 cleavage site 565034003964 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034003965 dimerization interface [polypeptide binding]; other site 565034003966 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034003967 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034003968 dimer interface [polypeptide binding]; other site 565034003969 putative CheW interface [polypeptide binding]; other site 565034003970 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 565034003971 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 565034003972 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 565034003973 catalytic core [active] 565034003974 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 565034003975 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 565034003976 putative efflux protein, MATE family; Region: matE; TIGR00797 565034003977 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 565034003978 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 565034003979 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 565034003980 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 565034003981 Ligand Binding Site [chemical binding]; other site 565034003982 TilS substrate C-terminal domain; Region: TilS_C; smart00977 565034003983 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 565034003984 nudix motif; other site 565034003985 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 565034003986 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 565034003987 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 565034003988 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 565034003989 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 565034003990 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565034003991 active site 565034003992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034003993 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565034003994 active site 565034003995 motif I; other site 565034003996 motif II; other site 565034003997 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034003998 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565034003999 active site 565034004000 phosphorylation site [posttranslational modification] 565034004001 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565034004002 active site 565034004003 phosphorylation site [posttranslational modification] 565034004004 Family of unknown function (DUF490); Region: DUF490; pfam04357 565034004005 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 565034004006 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 565034004007 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 565034004008 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 565034004009 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 565034004010 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 565034004011 Surface antigen; Region: Bac_surface_Ag; pfam01103 565034004012 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 565034004013 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 565034004014 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 565034004015 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 565034004016 trimer interface [polypeptide binding]; other site 565034004017 active site 565034004018 UDP-GlcNAc binding site [chemical binding]; other site 565034004019 lipid binding site [chemical binding]; lipid-binding site 565034004020 Cache domain; Region: Cache_1; pfam02743 565034004021 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034004022 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034004023 dimer interface [polypeptide binding]; other site 565034004024 putative CheW interface [polypeptide binding]; other site 565034004025 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 565034004026 Preprotein translocase subunit; Region: YajC; pfam02699 565034004027 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 565034004028 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 565034004029 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 565034004030 Protein export membrane protein; Region: SecD_SecF; cl14618 565034004031 SWIM zinc finger; Region: SWIM; pfam04434 565034004032 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 565034004033 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565034004034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034004035 homodimer interface [polypeptide binding]; other site 565034004036 catalytic residue [active] 565034004037 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 565034004038 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 565034004039 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 565034004040 trimer interface [polypeptide binding]; other site 565034004041 active site 565034004042 substrate binding site [chemical binding]; other site 565034004043 CoA binding site [chemical binding]; other site 565034004044 dihydrodipicolinate reductase; Provisional; Region: PRK00048 565034004045 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 565034004046 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 565034004047 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 565034004048 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 565034004049 dimer interface [polypeptide binding]; other site 565034004050 active site 565034004051 catalytic residue [active] 565034004052 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 565034004053 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 565034004054 metal binding site [ion binding]; metal-binding site 565034004055 dimer interface [polypeptide binding]; other site 565034004056 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 565034004057 flagellar motor switch protein; Validated; Region: PRK08119 565034004058 Chemotaxis phosphatase CheX; Region: CheX; cl15816 565034004059 flagellar motor switch protein FliN; Region: fliN; TIGR02480 565034004060 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 565034004061 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 565034004062 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 565034004063 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 565034004064 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565034004065 active site 565034004066 SLBB domain; Region: SLBB; pfam10531 565034004067 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 565034004068 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 565034004069 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 565034004070 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565034004071 Zn2+ binding site [ion binding]; other site 565034004072 Mg2+ binding site [ion binding]; other site 565034004073 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034004074 dimerization interface [polypeptide binding]; other site 565034004075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 565034004076 phosphorylation site [posttranslational modification] 565034004077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565034004078 ATP binding site [chemical binding]; other site 565034004079 Mg2+ binding site [ion binding]; other site 565034004080 G-X-G motif; other site 565034004081 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 565034004082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034004083 motif II; other site 565034004084 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 565034004085 active site 565034004086 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 565034004087 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 565034004088 Tetramer interface [polypeptide binding]; other site 565034004089 active site 565034004090 FMN-binding site [chemical binding]; other site 565034004091 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 565034004092 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 565034004093 active site 565034004094 NTP binding site [chemical binding]; other site 565034004095 metal binding triad [ion binding]; metal-binding site 565034004096 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 565034004097 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 565034004098 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 565034004099 Type III pantothenate kinase; Region: Pan_kinase; pfam03309 565034004100 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 565034004101 dimerization domain swap beta strand [polypeptide binding]; other site 565034004102 regulatory protein interface [polypeptide binding]; other site 565034004103 active site 565034004104 regulatory phosphorylation site [posttranslational modification]; other site 565034004105 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 565034004106 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 565034004107 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 565034004108 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 565034004109 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 565034004110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034004111 S-adenosylmethionine binding site [chemical binding]; other site 565034004112 flagellar motor protein MotB; Validated; Region: motB; PRK06667 565034004113 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 565034004114 ligand binding site [chemical binding]; other site 565034004115 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 565034004116 flagellar motor protein MotP; Reviewed; Region: PRK06926 565034004117 Flagellar protein (FlbD); Region: FlbD; cl00683 565034004118 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 565034004119 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 565034004120 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 565034004121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004122 binding surface 565034004123 TPR motif; other site 565034004124 Tetratricopeptide repeat; Region: TPR_16; pfam13432 565034004125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004126 TPR motif; other site 565034004127 binding surface 565034004128 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034004129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004130 TPR motif; other site 565034004131 binding surface 565034004132 TPR repeat; Region: TPR_11; pfam13414 565034004133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004134 binding surface 565034004135 TPR motif; other site 565034004136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004137 binding surface 565034004138 TPR motif; other site 565034004139 TPR repeat; Region: TPR_11; pfam13414 565034004140 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 565034004141 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 565034004142 active site 565034004143 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 565034004144 Peptidase family M23; Region: Peptidase_M23; pfam01551 565034004145 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 565034004146 active site 565034004147 metal binding site [ion binding]; metal-binding site 565034004148 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034004149 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034004150 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034004151 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034004152 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034004153 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034004154 peptide binding site [polypeptide binding]; other site 565034004155 FOG: CBS domain [General function prediction only]; Region: COG0517 565034004156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 565034004157 Transporter associated domain; Region: CorC_HlyC; smart01091 565034004158 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 565034004159 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 565034004160 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565034004161 Zn2+ binding site [ion binding]; other site 565034004162 Mg2+ binding site [ion binding]; other site 565034004163 PhoH-like protein; Region: PhoH; pfam02562 565034004164 Flavoprotein; Region: Flavoprotein; pfam02441 565034004165 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 565034004166 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565034004167 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565034004168 Walker A/P-loop; other site 565034004169 ATP binding site [chemical binding]; other site 565034004170 Q-loop/lid; other site 565034004171 ABC transporter signature motif; other site 565034004172 Walker B; other site 565034004173 D-loop; other site 565034004174 H-loop/switch region; other site 565034004175 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 565034004176 FtsX-like permease family; Region: FtsX; pfam02687 565034004177 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 565034004178 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 565034004179 FtsX-like permease family; Region: FtsX; pfam02687 565034004180 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 565034004181 NeuB family; Region: NeuB; pfam03102 565034004182 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 565034004183 NeuB binding interface [polypeptide binding]; other site 565034004184 putative substrate binding site [chemical binding]; other site 565034004185 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 565034004186 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 565034004187 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 565034004188 Protein export membrane protein; Region: SecD_SecF; cl14618 565034004189 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 565034004190 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 565034004191 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 565034004192 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 565034004193 DNA binding residues [nucleotide binding] 565034004194 Putative zinc-finger; Region: zf-HC2; pfam13490 565034004195 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 565034004196 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 565034004197 active site 565034004198 substrate binding site [chemical binding]; other site 565034004199 cosubstrate binding site; other site 565034004200 catalytic site [active] 565034004201 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 565034004202 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 565034004203 dimerization interface [polypeptide binding]; other site 565034004204 putative ATP binding site [chemical binding]; other site 565034004205 translation initiation factor IF-2; Region: IF-2; TIGR00487 565034004206 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 565034004207 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 565034004208 G1 box; other site 565034004209 putative GEF interaction site [polypeptide binding]; other site 565034004210 GTP/Mg2+ binding site [chemical binding]; other site 565034004211 Switch I region; other site 565034004212 G2 box; other site 565034004213 G3 box; other site 565034004214 Switch II region; other site 565034004215 G4 box; other site 565034004216 G5 box; other site 565034004217 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 565034004218 Translation-initiation factor 2; Region: IF-2; pfam11987 565034004219 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 565034004220 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 565034004221 Fumarase C-terminus; Region: Fumerase_C; cl00795 565034004222 fumarate hydratase; Provisional; Region: PRK06246 565034004223 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 565034004224 flagellin; Provisional; Region: PRK12804 565034004225 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 565034004226 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 565034004227 Peptidase family M28; Region: Peptidase_M28; pfam04389 565034004228 metal binding site [ion binding]; metal-binding site 565034004229 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 565034004230 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 565034004231 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 565034004232 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 565034004233 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 565034004234 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 565034004235 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 565034004236 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 565034004237 Na2 binding site [ion binding]; other site 565034004238 putative substrate binding site 1 [chemical binding]; other site 565034004239 Na binding site 1 [ion binding]; other site 565034004240 putative substrate binding site 2 [chemical binding]; other site 565034004241 glycerate kinase; Region: TIGR00045 565034004242 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 565034004243 putative active site pocket [active] 565034004244 4-fold oligomerization interface [polypeptide binding]; other site 565034004245 metal binding residues [ion binding]; metal-binding site 565034004246 3-fold/trimer interface [polypeptide binding]; other site 565034004247 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 565034004248 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 565034004249 putative active site [active] 565034004250 oxyanion strand; other site 565034004251 catalytic triad [active] 565034004252 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 565034004253 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 565034004254 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 565034004255 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 565034004256 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 565034004257 SLBB domain; Region: SLBB; pfam10531 565034004258 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 565034004259 putative dimer interface [polypeptide binding]; other site 565034004260 [2Fe-2S] cluster binding site [ion binding]; other site 565034004261 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 565034004262 interface (dimer of trimers) [polypeptide binding]; other site 565034004263 multifunctional aminopeptidase A; Provisional; Region: PRK00913 565034004264 Substrate-binding/catalytic site; other site 565034004265 Zn-binding sites [ion binding]; other site 565034004266 LPP20 lipoprotein; Region: LPP20; pfam02169 565034004267 LPP20 lipoprotein; Region: LPP20; cl15824 565034004268 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 565034004269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565034004270 NAD(P) binding site [chemical binding]; other site 565034004271 active site 565034004272 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 565034004273 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 565034004274 putative acyl-acceptor binding pocket; other site 565034004275 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 565034004276 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 565034004277 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 565034004278 protein binding site [polypeptide binding]; other site 565034004279 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 565034004280 protein binding site [polypeptide binding]; other site 565034004281 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 565034004282 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 565034004283 motif 1; other site 565034004284 active site 565034004285 motif 2; other site 565034004286 motif 3; other site 565034004287 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 565034004288 HEAT repeats; Region: HEAT_2; pfam13646 565034004289 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 565034004290 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 565034004291 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 565034004292 dimer interface [polypeptide binding]; other site 565034004293 active site 565034004294 CoA binding pocket [chemical binding]; other site 565034004295 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 565034004296 Restriction endonuclease; Region: Mrr_cat; pfam04471 565034004297 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 565034004298 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 565034004299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565034004300 NAD(P) binding site [chemical binding]; other site 565034004301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565034004302 active site 565034004303 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 565034004304 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 565034004305 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 565034004306 argininosuccinate lyase; Provisional; Region: PRK00855 565034004307 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 565034004308 active sites [active] 565034004309 tetramer interface [polypeptide binding]; other site 565034004310 argininosuccinate synthase; Provisional; Region: PRK13820 565034004311 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 565034004312 ANP binding site [chemical binding]; other site 565034004313 Substrate Binding Site II [chemical binding]; other site 565034004314 Substrate Binding Site I [chemical binding]; other site 565034004315 ornithine carbamoyltransferase; Provisional; Region: PRK00779 565034004316 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 565034004317 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 565034004318 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 565034004319 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 565034004320 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 565034004321 flagellin; Provisional; Region: PRK12804 565034004322 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 565034004323 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 565034004324 Protein of unknown function (DUF554); Region: DUF554; pfam04474 565034004325 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 565034004326 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 565034004327 putative NAD(P) binding site [chemical binding]; other site 565034004328 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 565034004329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034004330 binding surface 565034004331 TPR motif; other site 565034004332 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 565034004333 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 565034004334 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 565034004335 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 565034004336 homodimer interface [polypeptide binding]; other site 565034004337 substrate-cofactor binding pocket; other site 565034004338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034004339 catalytic residue [active] 565034004340 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 565034004341 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 565034004342 Catalytic site; other site 565034004343 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 565034004344 thiamine phosphate binding site [chemical binding]; other site 565034004345 active site 565034004346 pyrophosphate binding site [ion binding]; other site 565034004347 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 565034004348 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 565034004349 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 565034004350 active site 565034004351 HIGH motif; other site 565034004352 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 565034004353 KMSKS motif; other site 565034004354 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 565034004355 RNase_H superfamily; Region: RNase_H_2; pfam13482 565034004356 active site 565034004357 catalytic site [active] 565034004358 substrate binding site [chemical binding]; other site 565034004359 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 565034004360 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 565034004361 active site 565034004362 NAD binding site [chemical binding]; other site 565034004363 metal binding site [ion binding]; metal-binding site 565034004364 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 565034004365 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034004366 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034004367 peptide binding site [polypeptide binding]; other site 565034004368 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034004369 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034004370 peptide binding site [polypeptide binding]; other site 565034004371 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034004372 peptide binding site [polypeptide binding]; other site 565034004373 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 565034004374 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 565034004375 active site residue [active] 565034004376 Sporulation and spore germination; Region: Germane; pfam10646 565034004377 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 565034004378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004379 binding surface 565034004380 TPR motif; other site 565034004381 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 565034004382 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 565034004383 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 565034004384 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 565034004385 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 565034004386 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 565034004387 active site 565034004388 metal binding site [ion binding]; metal-binding site 565034004389 hypothetical protein; Validated; Region: PRK00110 565034004390 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 565034004391 active site 565034004392 putative DNA-binding cleft [nucleotide binding]; other site 565034004393 dimer interface [polypeptide binding]; other site 565034004394 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 565034004395 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 565034004396 putative substrate binding site [chemical binding]; other site 565034004397 putative ATP binding site [chemical binding]; other site 565034004398 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 565034004399 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 565034004400 NAD binding site [chemical binding]; other site 565034004401 homodimer interface [polypeptide binding]; other site 565034004402 active site 565034004403 substrate binding site [chemical binding]; other site 565034004404 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 565034004405 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 565034004406 G-X-X-G motif; other site 565034004407 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 565034004408 RxxxH motif; other site 565034004409 membrane protein insertase; Provisional; Region: PRK01318 565034004410 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 565034004411 Haemolytic domain; Region: Haemolytic; pfam01809 565034004412 Ribonuclease P; Region: Ribonuclease_P; pfam00825 565034004413 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 565034004414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 565034004415 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 565034004416 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 565034004417 dimer interface [polypeptide binding]; other site 565034004418 ADP-ribose binding site [chemical binding]; other site 565034004419 active site 565034004420 nudix motif; other site 565034004421 metal binding site [ion binding]; metal-binding site 565034004422 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 565034004423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 565034004424 dimer interface [polypeptide binding]; other site 565034004425 phosphorylation site [posttranslational modification] 565034004426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565034004427 ATP binding site [chemical binding]; other site 565034004428 Mg2+ binding site [ion binding]; other site 565034004429 G-X-G motif; other site 565034004430 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 565034004431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 565034004432 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 565034004433 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 565034004434 inhibitor-cofactor binding pocket; inhibition site 565034004435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034004436 catalytic residue [active] 565034004437 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 565034004438 intersubunit interface [polypeptide binding]; other site 565034004439 active site 565034004440 catalytic residue [active] 565034004441 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 565034004442 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 565034004443 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 565034004444 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 565034004445 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 565034004446 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 565034004447 ligand binding site [chemical binding]; other site 565034004448 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 565034004449 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 565034004450 ligand binding site [chemical binding]; other site 565034004451 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 565034004452 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 565034004453 ligand binding site [chemical binding]; other site 565034004454 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 565034004455 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 565034004456 ligand binding site [chemical binding]; other site 565034004457 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 565034004458 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 565034004459 Walker A/P-loop; other site 565034004460 ATP binding site [chemical binding]; other site 565034004461 Q-loop/lid; other site 565034004462 ABC transporter signature motif; other site 565034004463 Walker B; other site 565034004464 D-loop; other site 565034004465 H-loop/switch region; other site 565034004466 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 565034004467 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034004468 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034004469 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 565034004470 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 565034004471 TM-ABC transporter signature motif; other site 565034004472 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 565034004473 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 565034004474 TM-ABC transporter signature motif; other site 565034004475 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034004476 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 565034004477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034004478 active site 565034004479 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 565034004480 CoenzymeA binding site [chemical binding]; other site 565034004481 subunit interaction site [polypeptide binding]; other site 565034004482 PHB binding site; other site 565034004483 YtxH-like protein; Region: YtxH; pfam12732 565034004484 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 565034004485 glycyl-tRNA synthetase, dimeric type; Region: glyS_dimeric; TIGR00389 565034004486 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 565034004487 Peptidase family M50; Region: Peptidase_M50; pfam02163 565034004488 active site 565034004489 putative substrate binding region [chemical binding]; other site 565034004490 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 565034004491 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 565034004492 Walker A/P-loop; other site 565034004493 ATP binding site [chemical binding]; other site 565034004494 Q-loop/lid; other site 565034004495 ABC transporter signature motif; other site 565034004496 Walker B; other site 565034004497 D-loop; other site 565034004498 H-loop/switch region; other site 565034004499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034004500 dimer interface [polypeptide binding]; other site 565034004501 conserved gate region; other site 565034004502 putative PBP binding loops; other site 565034004503 ABC-ATPase subunit interface; other site 565034004504 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565034004505 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565034004506 substrate binding pocket [chemical binding]; other site 565034004507 membrane-bound complex binding site; other site 565034004508 hinge residues; other site 565034004509 LemA family; Region: LemA; cl00742 565034004510 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 565034004511 DNA binding site [nucleotide binding] 565034004512 domain linker motif; other site 565034004513 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 565034004514 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 565034004515 ligand binding site [chemical binding]; other site 565034004516 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 565034004517 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 565034004518 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 565034004519 FAD binding pocket [chemical binding]; other site 565034004520 FAD binding motif [chemical binding]; other site 565034004521 phosphate binding motif [ion binding]; other site 565034004522 beta-alpha-beta structure motif; other site 565034004523 NAD binding pocket [chemical binding]; other site 565034004524 Iron coordination center [ion binding]; other site 565034004525 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 565034004526 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 565034004527 ADP binding site [chemical binding]; other site 565034004528 phosphagen binding site; other site 565034004529 substrate specificity loop; other site 565034004530 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 565034004531 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 565034004532 substrate binding site; other site 565034004533 dimer interface; other site 565034004534 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034004535 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 565034004536 Transglycosylase; Region: Transgly; pfam00912 565034004537 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 565034004538 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 565034004539 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 565034004540 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034004541 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 565034004542 active site 565034004543 Zn binding site [ion binding]; other site 565034004544 HAMP domain; Region: HAMP; pfam00672 565034004545 dimerization interface [polypeptide binding]; other site 565034004546 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034004547 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034004548 dimer interface [polypeptide binding]; other site 565034004549 putative CheW interface [polypeptide binding]; other site 565034004550 Protein of unknown function DUF45; Region: DUF45; pfam01863 565034004551 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 565034004552 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 565034004553 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 565034004554 dimer interface [polypeptide binding]; other site 565034004555 active site 565034004556 CoA binding pocket [chemical binding]; other site 565034004557 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 565034004558 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 565034004559 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 565034004560 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 565034004561 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 565034004562 active site 565034004563 HIGH motif; other site 565034004564 KMSKS motif; other site 565034004565 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 565034004566 tRNA binding surface [nucleotide binding]; other site 565034004567 anticodon binding site; other site 565034004568 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 565034004569 dimer interface [polypeptide binding]; other site 565034004570 putative tRNA-binding site [nucleotide binding]; other site 565034004571 Cache domain; Region: Cache_1; pfam02743 565034004572 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034004573 dimerization interface [polypeptide binding]; other site 565034004574 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034004575 dimer interface [polypeptide binding]; other site 565034004576 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 565034004577 putative CheW interface [polypeptide binding]; other site 565034004578 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 565034004579 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 565034004580 active site 565034004581 putative catalytic site [active] 565034004582 phosphate binding site A [ion binding]; other site 565034004583 DNA binding site [nucleotide binding] 565034004584 metal binding site A [ion binding]; metal-binding site 565034004585 putative AP binding site [nucleotide binding]; other site 565034004586 putative metal binding site B [ion binding]; other site 565034004587 phosphate binding site B [ion binding]; other site 565034004588 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 565034004589 anti sigma factor interaction site; other site 565034004590 regulatory phosphorylation site [posttranslational modification]; other site 565034004591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004592 binding surface 565034004593 TPR motif; other site 565034004594 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 565034004595 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 565034004596 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 565034004597 EamA-like transporter family; Region: EamA; pfam00892 565034004598 MoxR-like ATPases [General function prediction only]; Region: COG0714 565034004599 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 565034004600 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 565034004601 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 565034004602 DHH family; Region: DHH; pfam01368 565034004603 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 565034004604 DHHA1 domain; Region: DHHA1; pfam02272 565034004605 TPR repeat; Region: TPR_11; pfam13414 565034004606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004607 binding surface 565034004608 TPR motif; other site 565034004609 TPR repeat; Region: TPR_11; pfam13414 565034004610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004611 binding surface 565034004612 TPR motif; other site 565034004613 TPR repeat; Region: TPR_11; pfam13414 565034004614 TPR repeat; Region: TPR_11; pfam13414 565034004615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004616 binding surface 565034004617 TPR motif; other site 565034004618 TPR repeat; Region: TPR_11; pfam13414 565034004619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004620 binding surface 565034004621 TPR motif; other site 565034004622 TPR repeat; Region: TPR_11; pfam13414 565034004623 TPR repeat; Region: TPR_11; pfam13414 565034004624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004625 binding surface 565034004626 TPR motif; other site 565034004627 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 565034004628 nudix motif; other site 565034004629 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_3; cd08770 565034004630 SxDxEG motif; other site 565034004631 putative active site [active] 565034004632 putative metal binding site [ion binding]; other site 565034004633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565034004634 Major Facilitator Superfamily; Region: MFS_1; pfam07690 565034004635 putative substrate translocation pore; other site 565034004636 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565034004637 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565034004638 active site 565034004639 catalytic tetrad [active] 565034004640 inner membrane protein; Provisional; Region: PRK11715 565034004641 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 565034004642 Malic enzyme, N-terminal domain; Region: malic; pfam00390 565034004643 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 565034004644 putative NAD(P) binding site [chemical binding]; other site 565034004645 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 565034004646 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034004647 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 565034004648 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034004649 TPR repeat; Region: TPR_11; pfam13414 565034004650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004651 binding surface 565034004652 TPR motif; other site 565034004653 TPR repeat; Region: TPR_11; pfam13414 565034004654 TPR repeat; Region: TPR_11; pfam13414 565034004655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004656 TPR motif; other site 565034004657 binding surface 565034004658 TPR repeat; Region: TPR_11; pfam13414 565034004659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004660 binding surface 565034004661 TPR motif; other site 565034004662 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 565034004663 seryl-tRNA synthetase; Provisional; Region: PRK05431 565034004664 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 565034004665 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 565034004666 dimer interface [polypeptide binding]; other site 565034004667 active site 565034004668 motif 1; other site 565034004669 motif 2; other site 565034004670 motif 3; other site 565034004671 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 565034004672 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 565034004673 putative NAD(P) binding site [chemical binding]; other site 565034004674 putative substrate binding site [chemical binding]; other site 565034004675 catalytic Zn binding site [ion binding]; other site 565034004676 structural Zn binding site [ion binding]; other site 565034004677 dimer interface [polypeptide binding]; other site 565034004678 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034004679 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 565034004680 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034004681 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 565034004682 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 565034004683 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 565034004684 recombination factor protein RarA; Reviewed; Region: PRK13342 565034004685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034004686 Walker A motif; other site 565034004687 ATP binding site [chemical binding]; other site 565034004688 Walker B motif; other site 565034004689 arginine finger; other site 565034004690 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 565034004691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034004692 dimerization interface [polypeptide binding]; other site 565034004693 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034004694 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034004695 dimer interface [polypeptide binding]; other site 565034004696 putative CheW interface [polypeptide binding]; other site 565034004697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004698 binding surface 565034004699 TPR motif; other site 565034004700 TPR repeat; Region: TPR_11; pfam13414 565034004701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004702 binding surface 565034004703 TPR motif; other site 565034004704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004705 binding surface 565034004706 TPR motif; other site 565034004707 TPR repeat; Region: TPR_11; pfam13414 565034004708 Uncharacterized conserved protein [Function unknown]; Region: COG2128 565034004709 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 565034004710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004711 binding surface 565034004712 TPR motif; other site 565034004713 Tetratricopeptide repeat; Region: TPR_16; pfam13432 565034004714 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034004715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004716 binding surface 565034004717 TPR motif; other site 565034004718 TPR repeat; Region: TPR_11; pfam13414 565034004719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004720 binding surface 565034004721 TPR repeat; Region: TPR_11; pfam13414 565034004722 TPR motif; other site 565034004723 TPR repeat; Region: TPR_11; pfam13414 565034004724 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034004725 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004726 binding surface 565034004727 TPR motif; other site 565034004728 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004729 binding surface 565034004730 TPR motif; other site 565034004731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004732 binding surface 565034004733 TPR motif; other site 565034004734 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 565034004735 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 565034004736 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 565034004737 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 565034004738 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 565034004739 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 565034004740 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 565034004741 Mg++ binding site [ion binding]; other site 565034004742 putative catalytic motif [active] 565034004743 putative substrate binding site [chemical binding]; other site 565034004744 thymidylate kinase; Validated; Region: tmk; PRK00698 565034004745 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 565034004746 TMP-binding site; other site 565034004747 ATP-binding site [chemical binding]; other site 565034004748 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 565034004749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034004750 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 565034004751 Walker A motif; other site 565034004752 ATP binding site [chemical binding]; other site 565034004753 Walker B motif; other site 565034004754 arginine finger; other site 565034004755 Cache domain; Region: Cache_1; pfam02743 565034004756 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034004757 dimer interface [polypeptide binding]; other site 565034004758 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 565034004759 putative CheW interface [polypeptide binding]; other site 565034004760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004761 binding surface 565034004762 TPR motif; other site 565034004763 TPR repeat; Region: TPR_11; pfam13414 565034004764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004765 binding surface 565034004766 TPR motif; other site 565034004767 TPR repeat; Region: TPR_11; pfam13414 565034004768 TPR repeat; Region: TPR_11; pfam13414 565034004769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034004770 binding surface 565034004771 TPR motif; other site 565034004772 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 565034004773 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 565034004774 active site 565034004775 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 565034004776 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034004777 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034004778 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034004779 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 565034004780 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 565034004781 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 565034004782 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034004783 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034004784 dimer interface [polypeptide binding]; other site 565034004785 putative CheW interface [polypeptide binding]; other site 565034004786 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 565034004787 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 565034004788 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 565034004789 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034004790 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034004791 HAMP domain; Region: HAMP; pfam00672 565034004792 dimerization interface [polypeptide binding]; other site 565034004793 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034004794 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034004795 dimer interface [polypeptide binding]; other site 565034004796 putative CheW interface [polypeptide binding]; other site 565034004797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034004798 dimerization interface [polypeptide binding]; other site 565034004799 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034004800 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034004801 dimer interface [polypeptide binding]; other site 565034004802 putative CheW interface [polypeptide binding]; other site 565034004803 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 565034004804 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 565034004805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034004806 homodimer interface [polypeptide binding]; other site 565034004807 catalytic residue [active] 565034004808 Restriction endonuclease; Region: Mrr_cat; pfam04471 565034004809 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 565034004810 Restriction endonuclease; Region: Mrr_cat; pfam04471 565034004811 Restriction endonuclease; Region: Mrr_cat; pfam04471 565034004812 Cell division protein ZapA; Region: ZapA; pfam05164 565034004813 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 565034004814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034004815 S-adenosylmethionine binding site [chemical binding]; other site 565034004816 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 565034004817 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 565034004818 putative phosphate acyltransferase; Provisional; Region: PRK05331 565034004819 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 565034004820 active site 565034004821 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 565034004822 SLBB domain; Region: SLBB; pfam10531 565034004823 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 565034004824 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 565034004825 FMN-binding domain; Region: FMN_bind; cl01081 565034004826 thiamine monophosphate kinase; Provisional; Region: PRK05731 565034004827 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 565034004828 ATP binding site [chemical binding]; other site 565034004829 dimerization interface [polypeptide binding]; other site 565034004830 putative acyltransferase; Provisional; Region: PRK05790 565034004831 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 565034004832 dimer interface [polypeptide binding]; other site 565034004833 active site 565034004834 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 565034004835 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034004836 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 565034004837 heterotetramer interface [polypeptide binding]; other site 565034004838 active site pocket [active] 565034004839 cleavage site 565034004840 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 565034004841 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 565034004842 Phosphoglycerate kinase; Region: PGK; pfam00162 565034004843 substrate binding site [chemical binding]; other site 565034004844 hinge regions; other site 565034004845 ADP binding site [chemical binding]; other site 565034004846 catalytic site [active] 565034004847 cytosolic glyceraldehyde 3-phosphate dehydrogenase; Provisional; Region: PTZ00434 565034004848 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 565034004849 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 565034004850 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 565034004851 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 565034004852 GatB domain; Region: GatB_Yqey; smart00845 565034004853 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 565034004854 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 565034004855 putative active site [active] 565034004856 Methyltransferase domain; Region: Methyltransf_23; pfam13489 565034004857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034004858 S-adenosylmethionine binding site [chemical binding]; other site 565034004859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034004860 FeS/SAM binding site; other site 565034004861 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 565034004862 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 565034004863 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 565034004864 Ligand binding site; other site 565034004865 Putative Catalytic site; other site 565034004866 DXD motif; other site 565034004867 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 565034004868 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 565034004869 active site 565034004870 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034004871 active site 565034004872 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 565034004873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565034004874 NAD(P) binding site [chemical binding]; other site 565034004875 active site 565034004876 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 565034004877 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 565034004878 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 565034004879 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 565034004880 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 565034004881 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 565034004882 active site 565034004883 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 565034004884 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 565034004885 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 565034004886 active site 565034004887 aspartate kinase; Reviewed; Region: PRK09034 565034004888 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 565034004889 nucleotide binding site [chemical binding]; other site 565034004890 substrate binding site [chemical binding]; other site 565034004891 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 565034004892 allosteric regulatory residue; other site 565034004893 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 565034004894 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 565034004895 Peptidase M30; Region: Peptidase_M30; pfam10460 565034004896 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 565034004897 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 565034004898 putative deacylase active site [active] 565034004899 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 565034004900 Chromate transporter; Region: Chromate_transp; pfam02417 565034004901 Chromate transporter; Region: Chromate_transp; pfam02417 565034004902 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 565034004903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034004904 AAA domain; Region: AAA_21; pfam13304 565034004905 Walker A/P-loop; other site 565034004906 ATP binding site [chemical binding]; other site 565034004907 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 565034004908 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 565034004909 metal ion-dependent adhesion site (MIDAS); other site 565034004910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 565034004911 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 565034004912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034004913 Walker A motif; other site 565034004914 ATP binding site [chemical binding]; other site 565034004915 Walker B motif; other site 565034004916 arginine finger; other site 565034004917 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 565034004918 Cache domain; Region: Cache_1; pfam02743 565034004919 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034004920 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034004921 dimer interface [polypeptide binding]; other site 565034004922 putative CheW interface [polypeptide binding]; other site 565034004923 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 565034004924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034004925 Walker A motif; other site 565034004926 ATP binding site [chemical binding]; other site 565034004927 Walker B motif; other site 565034004928 arginine finger; other site 565034004929 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 565034004930 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 565034004931 Peptidase family M23; Region: Peptidase_M23; pfam01551 565034004932 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 565034004933 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 565034004934 Rubredoxin; Region: Rubredoxin; pfam00301 565034004935 iron binding site [ion binding]; other site 565034004936 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 565034004937 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 565034004938 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 565034004939 alanine racemase; Reviewed; Region: alr; PRK00053 565034004940 active site 565034004941 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 565034004942 dimer interface [polypeptide binding]; other site 565034004943 substrate binding site [chemical binding]; other site 565034004944 catalytic residues [active] 565034004945 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034004946 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034004947 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034004948 dimer interface [polypeptide binding]; other site 565034004949 putative CheW interface [polypeptide binding]; other site 565034004950 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 565034004951 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 565034004952 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 565034004953 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 565034004954 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 565034004955 hinge; other site 565034004956 active site 565034004957 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 565034004958 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 565034004959 G1 box; other site 565034004960 GTP/Mg2+ binding site [chemical binding]; other site 565034004961 Switch I region; other site 565034004962 G2 box; other site 565034004963 Switch II region; other site 565034004964 G3 box; other site 565034004965 G4 box; other site 565034004966 G5 box; other site 565034004967 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 565034004968 G1 box; other site 565034004969 GTP/Mg2+ binding site [chemical binding]; other site 565034004970 Switch I region; other site 565034004971 G2 box; other site 565034004972 G3 box; other site 565034004973 Switch II region; other site 565034004974 G4 box; other site 565034004975 Predicted membrane protein [Function unknown]; Region: COG0344 565034004976 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 565034004977 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 565034004978 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 565034004979 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 565034004980 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 565034004981 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 565034004982 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 565034004983 substrate binding site [chemical binding]; other site 565034004984 glutamase interaction surface [polypeptide binding]; other site 565034004985 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034004986 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 565034004987 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 565034004988 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 565034004989 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 565034004990 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 565034004991 NAD binding site [chemical binding]; other site 565034004992 putative substrate binding site 2 [chemical binding]; other site 565034004993 putative substrate binding site 1 [chemical binding]; other site 565034004994 active site 565034004995 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 565034004996 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 565034004997 metal-binding site [ion binding] 565034004998 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565034004999 Soluble P-type ATPase [General function prediction only]; Region: COG4087 565034005000 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 565034005001 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 565034005002 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 565034005003 Walker A/P-loop; other site 565034005004 ATP binding site [chemical binding]; other site 565034005005 Q-loop/lid; other site 565034005006 ABC transporter signature motif; other site 565034005007 Walker B; other site 565034005008 D-loop; other site 565034005009 H-loop/switch region; other site 565034005010 NIL domain; Region: NIL; pfam09383 565034005011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034005012 conserved gate region; other site 565034005013 ABC-ATPase subunit interface; other site 565034005014 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 565034005015 tetramer (dimer of dimers) interface [polypeptide binding]; other site 565034005016 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 565034005017 NAD binding site [chemical binding]; other site 565034005018 dimer interface [polypeptide binding]; other site 565034005019 substrate binding site [chemical binding]; other site 565034005020 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 565034005021 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 565034005022 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 565034005023 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 565034005024 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 565034005025 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 565034005026 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 565034005027 active pocket/dimerization site; other site 565034005028 active site 565034005029 phosphorylation site [posttranslational modification] 565034005030 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 565034005031 Beta-lactamase; Region: Beta-lactamase; pfam00144 565034005032 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 565034005033 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 565034005034 putative active site [active] 565034005035 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 565034005036 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 565034005037 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 565034005038 putative active site [active] 565034005039 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 565034005040 active site 565034005041 phosphorylation site [posttranslational modification] 565034005042 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 565034005043 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 565034005044 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 565034005045 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 565034005046 dimer interface [polypeptide binding]; other site 565034005047 active site residues [active] 565034005048 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 565034005049 Predicted membrane protein [Function unknown]; Region: COG2510 565034005050 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14178 565034005051 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 565034005052 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 565034005053 homodimer interface [polypeptide binding]; other site 565034005054 NADP binding site [chemical binding]; other site 565034005055 substrate binding site [chemical binding]; other site 565034005056 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 565034005057 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 565034005058 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 565034005059 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 565034005060 putative active site [active] 565034005061 metal binding site [ion binding]; metal-binding site 565034005062 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 565034005063 intersubunit interface [polypeptide binding]; other site 565034005064 active site 565034005065 zinc binding site [ion binding]; other site 565034005066 Na+ binding site [ion binding]; other site 565034005067 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 565034005068 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 565034005069 active site 565034005070 P-loop; other site 565034005071 phosphorylation site [posttranslational modification] 565034005072 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 565034005073 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565034005074 active site 565034005075 phosphorylation site [posttranslational modification] 565034005076 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 565034005077 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 565034005078 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 565034005079 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565034005080 active site 565034005081 phosphorylation site [posttranslational modification] 565034005082 TonB C terminal; Region: TonB_2; pfam13103 565034005083 Predicted methyltransferases [General function prediction only]; Region: COG0313 565034005084 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 565034005085 putative SAM binding site [chemical binding]; other site 565034005086 putative homodimer interface [polypeptide binding]; other site 565034005087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 565034005088 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 565034005089 DNA binding residues [nucleotide binding] 565034005090 dimerization interface [polypeptide binding]; other site 565034005091 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 565034005092 EamA-like transporter family; Region: EamA; pfam00892 565034005093 EamA-like transporter family; Region: EamA; cl17759 565034005094 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 565034005095 diiron binding motif [ion binding]; other site 565034005096 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 565034005097 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 565034005098 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 565034005099 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 565034005100 active site 565034005101 HIGH motif; other site 565034005102 KMSK motif region; other site 565034005103 tRNA binding surface [nucleotide binding]; other site 565034005104 DALR anticodon binding domain; Region: DALR_1; smart00836 565034005105 anticodon binding site; other site 565034005106 Response regulator receiver domain; Region: Response_reg; pfam00072 565034005107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034005108 active site 565034005109 phosphorylation site [posttranslational modification] 565034005110 intermolecular recognition site; other site 565034005111 dimerization interface [polypeptide binding]; other site 565034005112 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 565034005113 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 565034005114 metal binding site [ion binding]; metal-binding site 565034005115 active site 565034005116 I-site; other site 565034005117 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 565034005118 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 565034005119 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 565034005120 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 565034005121 ligand binding site [chemical binding]; other site 565034005122 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 565034005123 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 565034005124 ligand binding site [chemical binding]; other site 565034005125 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 565034005126 Methyltransferase domain; Region: Methyltransf_23; pfam13489 565034005127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034005128 S-adenosylmethionine binding site [chemical binding]; other site 565034005129 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005130 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034005131 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005132 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 565034005133 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 565034005134 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 565034005135 oligomer interface [polypeptide binding]; other site 565034005136 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 565034005137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034005138 motif II; other site 565034005139 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034005140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005141 binding surface 565034005142 TPR repeat; Region: TPR_11; pfam13414 565034005143 TPR motif; other site 565034005144 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034005145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005146 binding surface 565034005147 TPR motif; other site 565034005148 TPR repeat; Region: TPR_11; pfam13414 565034005149 TPR repeat; Region: TPR_11; pfam13414 565034005150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005151 binding surface 565034005152 TPR motif; other site 565034005153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034005154 Walker B; other site 565034005155 D-loop; other site 565034005156 H-loop/switch region; other site 565034005157 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 565034005158 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 565034005159 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 565034005160 dimer interface [polypeptide binding]; other site 565034005161 anticodon binding site; other site 565034005162 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 565034005163 homodimer interface [polypeptide binding]; other site 565034005164 motif 1; other site 565034005165 active site 565034005166 motif 2; other site 565034005167 GAD domain; Region: GAD; pfam02938 565034005168 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 565034005169 active site 565034005170 motif 3; other site 565034005171 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565034005172 active site 565034005173 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 565034005174 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 565034005175 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 565034005176 Part of AAA domain; Region: AAA_19; pfam13245 565034005177 Family description; Region: UvrD_C_2; pfam13538 565034005178 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811 565034005179 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 565034005180 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 565034005181 4Fe-4S binding domain; Region: Fer4; pfam00037 565034005182 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034005183 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034005184 peptide binding site [polypeptide binding]; other site 565034005185 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 565034005186 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 565034005187 GDP-binding site [chemical binding]; other site 565034005188 ACT binding site; other site 565034005189 IMP binding site; other site 565034005190 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 565034005191 TPR repeat; Region: TPR_11; pfam13414 565034005192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005193 binding surface 565034005194 TPR motif; other site 565034005195 TPR repeat; Region: TPR_11; pfam13414 565034005196 TPR repeat; Region: TPR_11; pfam13414 565034005197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005198 binding surface 565034005199 TPR motif; other site 565034005200 TPR repeat; Region: TPR_11; pfam13414 565034005201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005202 binding surface 565034005203 TPR motif; other site 565034005204 TPR repeat; Region: TPR_11; pfam13414 565034005205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005206 binding surface 565034005207 TPR motif; other site 565034005208 TPR repeat; Region: TPR_11; pfam13414 565034005209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034005210 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 565034005211 Walker A motif; other site 565034005212 ATP binding site [chemical binding]; other site 565034005213 Walker B motif; other site 565034005214 arginine finger; other site 565034005215 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 565034005216 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034005217 dimerization interface [polypeptide binding]; other site 565034005218 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034005219 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034005220 dimer interface [polypeptide binding]; other site 565034005221 putative CheW interface [polypeptide binding]; other site 565034005222 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 565034005223 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 565034005224 putative active site [active] 565034005225 metal binding site [ion binding]; metal-binding site 565034005226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034005227 binding surface 565034005228 TPR motif; other site 565034005229 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 565034005230 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 565034005231 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 565034005232 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 565034005233 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 565034005234 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 565034005235 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 565034005236 Predicted chitinase [General function prediction only]; Region: COG3179 565034005237 catalytic residue [active] 565034005238 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034005239 dimerization interface [polypeptide binding]; other site 565034005240 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034005241 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034005242 dimer interface [polypeptide binding]; other site 565034005243 putative CheW interface [polypeptide binding]; other site 565034005244 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034005245 dimerization interface [polypeptide binding]; other site 565034005246 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034005247 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034005248 dimer interface [polypeptide binding]; other site 565034005249 putative CheW interface [polypeptide binding]; other site 565034005250 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 565034005251 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 565034005252 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 565034005253 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 565034005254 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 565034005255 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 565034005256 tetramer interface [polypeptide binding]; other site 565034005257 catalytic Zn binding site [ion binding]; other site 565034005258 NADP binding site [chemical binding]; other site 565034005259 Thymidine kinase; Region: TK; pfam00265 565034005260 Protein of unknown function (DUF511); Region: DUF511; cl01114 565034005261 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 565034005262 AAA domain; Region: AAA_21; pfam13304 565034005263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034005264 Walker B; other site 565034005265 D-loop; other site 565034005266 H-loop/switch region; other site 565034005267 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 565034005268 Peptidase family U32; Region: Peptidase_U32; pfam01136 565034005269 Collagenase; Region: DUF3656; pfam12392 565034005270 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 565034005271 AMP-binding enzyme; Region: AMP-binding; pfam00501 565034005272 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 565034005273 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 565034005274 acyl-activating enzyme (AAE) consensus motif; other site 565034005275 acyl-activating enzyme (AAE) consensus motif; other site 565034005276 AMP binding site [chemical binding]; other site 565034005277 active site 565034005278 CoA binding site [chemical binding]; other site 565034005279 Haemolysin-III related; Region: HlyIII; cl03831 565034005280 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 565034005281 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 565034005282 ATP-grasp domain; Region: ATP-grasp_4; cl17255 565034005283 DinB family; Region: DinB; cl17821 565034005284 RecX family; Region: RecX; cl00936 565034005285 YcxB-like protein; Region: YcxB; pfam14317 565034005286 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 565034005287 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 565034005288 active site 565034005289 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 565034005290 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 565034005291 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 565034005292 protein binding site [polypeptide binding]; other site 565034005293 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 565034005294 Catalytic dyad [active] 565034005295 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005296 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005297 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005298 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005299 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 565034005300 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005301 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005302 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 565034005303 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 565034005304 TPR repeat; Region: TPR_11; pfam13414 565034005305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005306 binding surface 565034005307 TPR motif; other site 565034005308 TPR repeat; Region: TPR_11; pfam13414 565034005309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005310 binding surface 565034005311 TPR motif; other site 565034005312 TPR repeat; Region: TPR_11; pfam13414 565034005313 TPR repeat; Region: TPR_11; pfam13414 565034005314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005315 binding surface 565034005316 TPR motif; other site 565034005317 TPR repeat; Region: TPR_11; pfam13414 565034005318 TPR repeat; Region: TPR_11; pfam13414 565034005319 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 565034005320 catalytic core [active] 565034005321 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 565034005322 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 565034005323 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 565034005324 Ligand binding site; other site 565034005325 oligomer interface; other site 565034005326 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565034005327 active site 565034005328 phosphorylation site [posttranslational modification] 565034005329 enolase; Provisional; Region: eno; PRK00077 565034005330 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 565034005331 dimer interface [polypeptide binding]; other site 565034005332 metal binding site [ion binding]; metal-binding site 565034005333 substrate binding pocket [chemical binding]; other site 565034005334 Hemerythrin; Region: Hemerythrin; cd12107 565034005335 Fe binding site [ion binding]; other site 565034005336 Hemerythrin; Region: Hemerythrin; cd12107 565034005337 Fe binding site [ion binding]; other site 565034005338 NAD-dependent deacetylase; Provisional; Region: PRK00481 565034005339 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 565034005340 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 565034005341 CoA binding domain; Region: CoA_binding; smart00881 565034005342 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005343 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005344 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005345 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005346 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005347 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 565034005348 putative active site [active] 565034005349 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 565034005350 Walker A/P-loop; other site 565034005351 ATP binding site [chemical binding]; other site 565034005352 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 565034005353 ABC transporter signature motif; other site 565034005354 Walker B; other site 565034005355 D-loop; other site 565034005356 H-loop/switch region; other site 565034005357 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 565034005358 MgtC family; Region: MgtC; pfam02308 565034005359 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 565034005360 active pocket/dimerization site; other site 565034005361 active site 565034005362 phosphorylation site [posttranslational modification] 565034005363 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565034005364 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565034005365 substrate binding pocket [chemical binding]; other site 565034005366 membrane-bound complex binding site; other site 565034005367 hinge residues; other site 565034005368 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565034005369 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565034005370 substrate binding pocket [chemical binding]; other site 565034005371 membrane-bound complex binding site; other site 565034005372 hinge residues; other site 565034005373 GTP-binding protein LepA; Provisional; Region: PRK05433 565034005374 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 565034005375 G1 box; other site 565034005376 putative GEF interaction site [polypeptide binding]; other site 565034005377 GTP/Mg2+ binding site [chemical binding]; other site 565034005378 Switch I region; other site 565034005379 G2 box; other site 565034005380 G3 box; other site 565034005381 Switch II region; other site 565034005382 G4 box; other site 565034005383 G5 box; other site 565034005384 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 565034005385 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 565034005386 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 565034005387 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 565034005388 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 565034005389 NAD(P) binding site [chemical binding]; other site 565034005390 homodimer interface [polypeptide binding]; other site 565034005391 substrate binding site [chemical binding]; other site 565034005392 active site 565034005393 PIN domain; Region: PIN_Smg5-Smg6-like; cd09880 565034005394 putative active site [active] 565034005395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565034005396 active site 565034005397 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 565034005398 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 565034005399 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 565034005400 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 565034005401 Ligand binding site [chemical binding]; other site 565034005402 Electron transfer flavoprotein domain; Region: ETF; pfam01012 565034005403 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 565034005404 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 565034005405 FAD binding site [chemical binding]; other site 565034005406 homotetramer interface [polypeptide binding]; other site 565034005407 substrate binding pocket [chemical binding]; other site 565034005408 catalytic base [active] 565034005409 V-type ATP synthase subunit E; Provisional; Region: PRK01005 565034005410 V-type ATP synthase subunit E; Provisional; Region: PRK01558 565034005411 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 565034005412 V-type ATP synthase subunit A; Provisional; Region: PRK04192 565034005413 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 565034005414 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 565034005415 Walker A motif/ATP binding site; other site 565034005416 Walker B motif; other site 565034005417 V-type ATP synthase subunit B; Provisional; Region: PRK02118 565034005418 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 565034005419 Walker A motif homologous position; other site 565034005420 Walker B motif; other site 565034005421 V-type ATP synthase subunit D; Provisional; Region: PRK02195 565034005422 V-type ATP synthase subunit I; Validated; Region: PRK05771 565034005423 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 565034005424 V-type ATP synthase subunit K; Provisional; Region: PRK09621 565034005425 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 565034005426 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 565034005427 substrate binding site [chemical binding]; other site 565034005428 tetramer interface [polypeptide binding]; other site 565034005429 catalytic residue [active] 565034005430 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 565034005431 Na2 binding site [ion binding]; other site 565034005432 putative substrate binding site 1 [chemical binding]; other site 565034005433 Na binding site 1 [ion binding]; other site 565034005434 putative substrate binding site 2 [chemical binding]; other site 565034005435 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 565034005436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034005437 Walker A motif; other site 565034005438 ATP binding site [chemical binding]; other site 565034005439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 565034005440 Walker B motif; other site 565034005441 arginine finger; other site 565034005442 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 565034005443 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565034005444 RNA binding surface [nucleotide binding]; other site 565034005445 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 565034005446 pseudouridine synthase; Region: TIGR00093 565034005447 active site 565034005448 Leucine rich repeat; Region: LRR_8; pfam13855 565034005449 Leucine rich repeat; Region: LRR_8; pfam13855 565034005450 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 565034005451 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 565034005452 active site 565034005453 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 565034005454 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 565034005455 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 565034005456 putative ribose interaction site [chemical binding]; other site 565034005457 putative ADP binding site [chemical binding]; other site 565034005458 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 565034005459 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 565034005460 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 565034005461 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 565034005462 dimerization interface [polypeptide binding]; other site 565034005463 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034005464 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034005465 dimer interface [polypeptide binding]; other site 565034005466 putative CheW interface [polypeptide binding]; other site 565034005467 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 565034005468 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 565034005469 4Fe-4S binding domain; Region: Fer4_6; pfam12837 565034005470 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 565034005471 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 565034005472 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 565034005473 dimer interface [polypeptide binding]; other site 565034005474 PYR/PP interface [polypeptide binding]; other site 565034005475 TPP binding site [chemical binding]; other site 565034005476 substrate binding site [chemical binding]; other site 565034005477 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 565034005478 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 565034005479 TPP-binding site [chemical binding]; other site 565034005480 putative dimer interface [polypeptide binding]; other site 565034005481 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 565034005482 peptidase T; Region: peptidase-T; TIGR01882 565034005483 metal binding site [ion binding]; metal-binding site 565034005484 dimer interface [polypeptide binding]; other site 565034005485 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 565034005486 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 565034005487 TPR repeat; Region: TPR_11; pfam13414 565034005488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005489 binding surface 565034005490 TPR motif; other site 565034005491 TPR repeat; Region: TPR_11; pfam13414 565034005492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005493 binding surface 565034005494 TPR motif; other site 565034005495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005496 binding surface 565034005497 TPR repeat; Region: TPR_11; pfam13414 565034005498 TPR motif; other site 565034005499 TPR repeat; Region: TPR_11; pfam13414 565034005500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005501 binding surface 565034005502 TPR repeat; Region: TPR_11; pfam13414 565034005503 TPR motif; other site 565034005504 TPR repeat; Region: TPR_11; pfam13414 565034005505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005506 binding surface 565034005507 TPR motif; other site 565034005508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005509 binding surface 565034005510 TPR repeat; Region: TPR_11; pfam13414 565034005511 TPR motif; other site 565034005512 Ferredoxin [Energy production and conversion]; Region: COG1146 565034005513 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 565034005514 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 565034005515 dimer interface [polypeptide binding]; other site 565034005516 PYR/PP interface [polypeptide binding]; other site 565034005517 TPP binding site [chemical binding]; other site 565034005518 substrate binding site [chemical binding]; other site 565034005519 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 565034005520 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 565034005521 TPP-binding site [chemical binding]; other site 565034005522 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 565034005523 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 565034005524 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034005525 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034005526 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 565034005527 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 565034005528 putative active site [active] 565034005529 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 565034005530 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034005531 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 565034005532 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 565034005533 Cache domain; Region: Cache_1; pfam02743 565034005534 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034005535 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034005536 dimer interface [polypeptide binding]; other site 565034005537 putative CheW interface [polypeptide binding]; other site 565034005538 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 565034005539 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 565034005540 active site 565034005541 Mn binding site [ion binding]; other site 565034005542 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 565034005543 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565034005544 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565034005545 Predicted dehydrogenase [General function prediction only]; Region: COG0579 565034005546 hydroxyglutarate oxidase; Provisional; Region: PRK11728 565034005547 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 565034005548 glycerol kinase; Provisional; Region: glpK; PRK00047 565034005549 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 565034005550 N- and C-terminal domain interface [polypeptide binding]; other site 565034005551 active site 565034005552 MgATP binding site [chemical binding]; other site 565034005553 catalytic site [active] 565034005554 metal binding site [ion binding]; metal-binding site 565034005555 glycerol binding site [chemical binding]; other site 565034005556 homotetramer interface [polypeptide binding]; other site 565034005557 homodimer interface [polypeptide binding]; other site 565034005558 FBP binding site [chemical binding]; other site 565034005559 protein IIAGlc interface [polypeptide binding]; other site 565034005560 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 565034005561 amphipathic channel; other site 565034005562 Asn-Pro-Ala signature motifs; other site 565034005563 Rubrerythrin [Energy production and conversion]; Region: COG1592 565034005564 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 565034005565 binuclear metal center [ion binding]; other site 565034005566 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 565034005567 iron binding site [ion binding]; other site 565034005568 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 565034005569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 565034005570 putative substrate translocation pore; other site 565034005571 TPR repeat; Region: TPR_11; pfam13414 565034005572 binding surface 565034005573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034005574 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 565034005575 active site 565034005576 catalytic triad [active] 565034005577 oxyanion hole [active] 565034005578 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 565034005579 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 565034005580 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 565034005581 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565034005582 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565034005583 active site 565034005584 catalytic tetrad [active] 565034005585 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 565034005586 active site 565034005587 intersubunit interactions; other site 565034005588 catalytic residue [active] 565034005589 Phage terminase large subunit; Region: Terminase_3; cl12054 565034005590 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 565034005591 catalytic triad [active] 565034005592 conserved cis-peptide bond; other site 565034005593 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 565034005594 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 565034005595 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 565034005596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005597 binding surface 565034005598 TPR repeat; Region: TPR_11; pfam13414 565034005599 TPR motif; other site 565034005600 TPR repeat; Region: TPR_11; pfam13414 565034005601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005602 binding surface 565034005603 TPR motif; other site 565034005604 Smr domain; Region: Smr; cl02619 565034005605 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 565034005606 DNA binding residues [nucleotide binding] 565034005607 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 565034005608 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 565034005609 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 565034005610 DNA binding residues [nucleotide binding] 565034005611 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 565034005612 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 565034005613 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 565034005614 nucleotide binding pocket [chemical binding]; other site 565034005615 K-X-D-G motif; other site 565034005616 catalytic site [active] 565034005617 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 565034005618 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 565034005619 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 565034005620 Dimer interface [polypeptide binding]; other site 565034005621 TPR repeat; Region: TPR_11; pfam13414 565034005622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005623 binding surface 565034005624 TPR motif; other site 565034005625 TPR repeat; Region: TPR_11; pfam13414 565034005626 TPR repeat; Region: TPR_11; pfam13414 565034005627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005628 binding surface 565034005629 TPR motif; other site 565034005630 TPR repeat; Region: TPR_11; pfam13414 565034005631 TPR repeat; Region: TPR_11; pfam13414 565034005632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005633 binding surface 565034005634 TPR motif; other site 565034005635 TPR repeat; Region: TPR_11; pfam13414 565034005636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005637 binding surface 565034005638 TPR motif; other site 565034005639 TPR repeat; Region: TPR_11; pfam13414 565034005640 TPR repeat; Region: TPR_11; pfam13414 565034005641 TPR repeat; Region: TPR_11; pfam13414 565034005642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005643 binding surface 565034005644 TPR motif; other site 565034005645 TPR repeat; Region: TPR_11; pfam13414 565034005646 Tetratricopeptide repeat; Region: TPR_16; pfam13432 565034005647 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 565034005648 dimerization interface [polypeptide binding]; other site 565034005649 putative active cleft [active] 565034005650 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 565034005651 Family of unknown function (DUF438); Region: DUF438; pfam04282 565034005652 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 565034005653 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 565034005654 hypothetical protein; Region: PHA00684 565034005655 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 565034005656 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 565034005657 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 565034005658 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 565034005659 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565034005660 Zn2+ binding site [ion binding]; other site 565034005661 Mg2+ binding site [ion binding]; other site 565034005662 hypothetical protein; Reviewed; Region: PRK12497 565034005663 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 565034005664 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 565034005665 putative active site [active] 565034005666 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 565034005667 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565034005668 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565034005669 substrate binding pocket [chemical binding]; other site 565034005670 membrane-bound complex binding site; other site 565034005671 hinge residues; other site 565034005672 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 565034005673 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 565034005674 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 565034005675 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 565034005676 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 565034005677 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 565034005678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005679 TPR motif; other site 565034005680 binding surface 565034005681 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034005682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005683 binding surface 565034005684 TPR motif; other site 565034005685 TPR repeat; Region: TPR_11; pfam13414 565034005686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005687 binding surface 565034005688 TPR motif; other site 565034005689 TPR repeat; Region: TPR_11; pfam13414 565034005690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034005691 binding surface 565034005692 TPR motif; other site 565034005693 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 565034005694 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565034005695 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 565034005696 Rubrerythrin [Energy production and conversion]; Region: COG1592 565034005697 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 565034005698 binuclear metal center [ion binding]; other site 565034005699 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 565034005700 iron binding site [ion binding]; other site 565034005701 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 565034005702 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 565034005703 putative active site [active] 565034005704 PhoH-like protein; Region: PhoH; pfam02562 565034005705 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 565034005706 active site 565034005707 substrate binding site [chemical binding]; other site 565034005708 trimer interface [polypeptide binding]; other site 565034005709 CoA binding site [chemical binding]; other site 565034005710 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 565034005711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 565034005712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 565034005713 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 565034005714 dimerization interface [polypeptide binding]; other site 565034005715 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 565034005716 active site 565034005717 catalytic residues [active] 565034005718 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 565034005719 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 565034005720 catalytic motif [active] 565034005721 Zn binding site [ion binding]; other site 565034005722 RibD C-terminal domain; Region: RibD_C; cl17279 565034005723 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 565034005724 Lumazine binding domain; Region: Lum_binding; pfam00677 565034005725 Lumazine binding domain; Region: Lum_binding; pfam00677 565034005726 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 565034005727 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 565034005728 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 565034005729 dimerization interface [polypeptide binding]; other site 565034005730 active site 565034005731 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 565034005732 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 565034005733 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 565034005734 homopentamer interface [polypeptide binding]; other site 565034005735 active site 565034005736 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 565034005737 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 565034005738 active site 565034005739 NTP binding site [chemical binding]; other site 565034005740 metal binding triad [ion binding]; metal-binding site 565034005741 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005742 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005743 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034005744 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005745 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005746 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005747 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005748 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005749 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005750 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005751 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005752 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005753 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005754 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005755 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005756 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034005757 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034005758 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 565034005759 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 565034005760 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 565034005761 HlyD family secretion protein; Region: HlyD_3; pfam13437 565034005762 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 565034005763 Protein export membrane protein; Region: SecD_SecF; cl14618 565034005764 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 565034005765 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 565034005766 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 565034005767 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 565034005768 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 565034005769 carboxyltransferase (CT) interaction site; other site 565034005770 biotinylation site [posttranslational modification]; other site 565034005771 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 565034005772 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 565034005773 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 565034005774 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 565034005775 signal recognition particle protein; Provisional; Region: PRK10867 565034005776 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 565034005777 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 565034005778 Signal peptide binding domain; Region: SRP_SPB; pfam02978 565034005779 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 565034005780 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 565034005781 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 565034005782 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 565034005783 RimM N-terminal domain; Region: RimM; pfam01782 565034005784 PRC-barrel domain; Region: PRC; pfam05239 565034005785 Domain of unknown function (DUF305); Region: DUF305; pfam03713 565034005786 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 565034005787 SmpB-tmRNA interface; other site 565034005788 Oxoglutarate and iron-dependent oxygenase degradation C-term; Region: Ofd1_CTDD; pfam10637 565034005789 DHHC palmitoyltransferase; Region: zf-DHHC; pfam01529 565034005790 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 565034005791 oligomerisation interface [polypeptide binding]; other site 565034005792 mobile loop; other site 565034005793 roof hairpin; other site 565034005794 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565034005795 active site 565034005796 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 565034005797 N- and C-terminal domain interface [polypeptide binding]; other site 565034005798 D-xylulose kinase; Region: XylB; TIGR01312 565034005799 active site 565034005800 MgATP binding site [chemical binding]; other site 565034005801 catalytic site [active] 565034005802 metal binding site [ion binding]; metal-binding site 565034005803 xylulose binding site [chemical binding]; other site 565034005804 homodimer interface [polypeptide binding]; other site 565034005805 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034005806 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034005807 peptide binding site [polypeptide binding]; other site 565034005808 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 565034005809 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 565034005810 inhibitor-cofactor binding pocket; inhibition site 565034005811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 565034005812 catalytic residue [active] 565034005813 AAA domain; Region: AAA_26; pfam13500 565034005814 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 565034005815 biotin synthase; Region: bioB; TIGR00433 565034005816 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034005817 FeS/SAM binding site; other site 565034005818 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 565034005819 Biotin operon repressor [Transcription]; Region: BirA; COG1654 565034005820 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 565034005821 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 565034005822 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 565034005823 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 565034005824 putative dimer interface [polypeptide binding]; other site 565034005825 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 565034005826 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 565034005827 putative dimer interface [polypeptide binding]; other site 565034005828 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 565034005829 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 565034005830 putative ligand binding site [chemical binding]; other site 565034005831 putative NAD binding site [chemical binding]; other site 565034005832 catalytic site [active] 565034005833 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 565034005834 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 565034005835 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 565034005836 catalytic residue [active] 565034005837 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 565034005838 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 565034005839 active site 565034005840 Int/Topo IB signature motif; other site 565034005841 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 565034005842 metal-binding site [ion binding] 565034005843 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565034005844 Zn2+ binding site [ion binding]; other site 565034005845 Mg2+ binding site [ion binding]; other site 565034005846 Flagellin N-methylase; Region: FliB; pfam03692 565034005847 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 565034005848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565034005849 DNA-binding site [nucleotide binding]; DNA binding site 565034005850 FCD domain; Region: FCD; pfam07729 565034005851 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 565034005852 Sulfatase; Region: Sulfatase; cl17466 565034005853 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 565034005854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034005855 S-adenosylmethionine binding site [chemical binding]; other site 565034005856 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034005857 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034005858 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 565034005859 ApbE family; Region: ApbE; pfam02424 565034005860 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 565034005861 Divergent AAA domain; Region: AAA_4; pfam04326 565034005862 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 565034005863 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565034005864 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565034005865 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 565034005866 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 565034005867 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 565034005868 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 565034005869 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 565034005870 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 565034005871 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 565034005872 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 565034005873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 565034005874 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 565034005875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 565034005876 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 565034005877 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 565034005878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034005879 S-adenosylmethionine binding site [chemical binding]; other site 565034005880 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 565034005881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034005882 active site 565034005883 motif I; other site 565034005884 motif II; other site 565034005885 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 565034005886 dimer interface [polypeptide binding]; other site 565034005887 catalytic triad [active] 565034005888 Uncharacterized conserved protein [Function unknown]; Region: COG0432 565034005889 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 565034005890 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034005891 FeS/SAM binding site; other site 565034005892 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 565034005893 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 565034005894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034005895 Walker A/P-loop; other site 565034005896 ATP binding site [chemical binding]; other site 565034005897 AAA domain; Region: AAA_21; pfam13304 565034005898 RIP metalloprotease RseP; Region: TIGR00054 565034005899 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 565034005900 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 565034005901 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 565034005902 protein binding site [polypeptide binding]; other site 565034005903 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 565034005904 putative substrate binding region [chemical binding]; other site 565034005905 CHAT domain; Region: CHAT; cl17868 565034005906 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 565034005907 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 565034005908 amidase catalytic site [active] 565034005909 Zn binding residues [ion binding]; other site 565034005910 substrate binding site [chemical binding]; other site 565034005911 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 565034005912 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 565034005913 active site 565034005914 homodimer interface [polypeptide binding]; other site 565034005915 SAM binding site [chemical binding]; other site 565034005916 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 565034005917 Mrr N-terminal domain; Region: Mrr_N; pfam14338 565034005918 Restriction endonuclease; Region: Mrr_cat; pfam04471 565034005919 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 565034005920 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 565034005921 ligand binding site [chemical binding]; other site 565034005922 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 565034005923 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 565034005924 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 565034005925 metal binding site [ion binding]; metal-binding site 565034005926 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 565034005927 S17 interaction site [polypeptide binding]; other site 565034005928 S8 interaction site; other site 565034005929 16S rRNA interaction site [nucleotide binding]; other site 565034005930 streptomycin interaction site [chemical binding]; other site 565034005931 23S rRNA interaction site [nucleotide binding]; other site 565034005932 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 565034005933 30S ribosomal protein S7; Validated; Region: PRK05302 565034005934 elongation factor G; Reviewed; Region: PRK00007 565034005935 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 565034005936 G1 box; other site 565034005937 putative GEF interaction site [polypeptide binding]; other site 565034005938 GTP/Mg2+ binding site [chemical binding]; other site 565034005939 Switch I region; other site 565034005940 G2 box; other site 565034005941 G3 box; other site 565034005942 Switch II region; other site 565034005943 G4 box; other site 565034005944 G5 box; other site 565034005945 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 565034005946 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 565034005947 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 565034005948 elongation factor Tu; Reviewed; Region: PRK00049 565034005949 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 565034005950 G1 box; other site 565034005951 GEF interaction site [polypeptide binding]; other site 565034005952 GTP/Mg2+ binding site [chemical binding]; other site 565034005953 Switch I region; other site 565034005954 G2 box; other site 565034005955 G3 box; other site 565034005956 Switch II region; other site 565034005957 G4 box; other site 565034005958 G5 box; other site 565034005959 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 565034005960 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 565034005961 Antibiotic Binding Site [chemical binding]; other site 565034005962 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 565034005963 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 565034005964 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 565034005965 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 565034005966 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 565034005967 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 565034005968 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 565034005969 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 565034005970 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 565034005971 putative translocon binding site; other site 565034005972 protein-rRNA interface [nucleotide binding]; other site 565034005973 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 565034005974 G-X-X-G motif; other site 565034005975 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 565034005976 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 565034005977 23S rRNA interface [nucleotide binding]; other site 565034005978 5S rRNA interface [nucleotide binding]; other site 565034005979 putative antibiotic binding site [chemical binding]; other site 565034005980 L25 interface [polypeptide binding]; other site 565034005981 L27 interface [polypeptide binding]; other site 565034005982 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 565034005983 L23 interface [polypeptide binding]; other site 565034005984 trigger factor interaction site; other site 565034005985 23S rRNA interface [nucleotide binding]; other site 565034005986 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 565034005987 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 565034005988 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 565034005989 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 565034005990 RNA binding site [nucleotide binding]; other site 565034005991 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 565034005992 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 565034005993 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 565034005994 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 565034005995 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 565034005996 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 565034005997 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 565034005998 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 565034005999 5S rRNA interface [nucleotide binding]; other site 565034006000 23S rRNA interface [nucleotide binding]; other site 565034006001 L5 interface [polypeptide binding]; other site 565034006002 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 565034006003 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 565034006004 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 565034006005 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 565034006006 23S rRNA binding site [nucleotide binding]; other site 565034006007 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 565034006008 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 565034006009 SecY translocase; Region: SecY; pfam00344 565034006010 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 565034006011 rRNA binding site [nucleotide binding]; other site 565034006012 predicted 30S ribosome binding site; other site 565034006013 30S ribosomal protein S13; Region: bact_S13; TIGR03631 565034006014 30S ribosomal protein S11; Validated; Region: PRK05309 565034006015 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 565034006016 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 565034006017 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565034006018 RNA binding surface [nucleotide binding]; other site 565034006019 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 565034006020 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 565034006021 alphaNTD homodimer interface [polypeptide binding]; other site 565034006022 alphaNTD - beta interaction site [polypeptide binding]; other site 565034006023 alphaNTD - beta' interaction site [polypeptide binding]; other site 565034006024 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 565034006025 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 565034006026 transcription termination factor Rho; Provisional; Region: rho; PRK09376 565034006027 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 565034006028 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 565034006029 RNA binding site [nucleotide binding]; other site 565034006030 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 565034006031 Walker A motif; other site 565034006032 ATP binding site [chemical binding]; other site 565034006033 Walker B motif; other site 565034006034 Smr domain; Region: Smr; pfam01713 565034006035 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 565034006036 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 565034006037 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 565034006038 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 565034006039 active site 565034006040 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 565034006041 AAA domain; Region: AAA_11; pfam13086 565034006042 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565034006043 ATP binding site [chemical binding]; other site 565034006044 AAA domain; Region: AAA_30; pfam13604 565034006045 AAA domain; Region: AAA_12; pfam13087 565034006046 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 565034006047 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 565034006048 dimer interface [polypeptide binding]; other site 565034006049 active site 565034006050 metal binding site [ion binding]; metal-binding site 565034006051 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006052 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006053 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006054 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006055 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006056 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006057 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006058 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034006060 Tetratricopeptide repeat; Region: TPR_16; pfam13432 565034006061 TPR motif; other site 565034006062 binding surface 565034006063 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034006064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034006065 TPR motif; other site 565034006066 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 565034006067 active site 565034006068 HslU subunit interaction site [polypeptide binding]; other site 565034006069 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 565034006070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034006071 Walker A motif; other site 565034006072 ATP binding site [chemical binding]; other site 565034006073 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 565034006074 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 565034006075 Hemerythrin; Region: Hemerythrin; cd12107 565034006076 Fe binding site [ion binding]; other site 565034006077 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 565034006078 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 565034006079 putative active site [active] 565034006080 catalytic triad [active] 565034006081 putative dimer interface [polypeptide binding]; other site 565034006082 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 565034006083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034006084 active site 565034006085 phosphorylation site [posttranslational modification] 565034006086 intermolecular recognition site; other site 565034006087 dimerization interface [polypeptide binding]; other site 565034006088 CheB methylesterase; Region: CheB_methylest; pfam01339 565034006089 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14611 565034006090 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 565034006091 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 565034006092 Substrate binding site; other site 565034006093 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 565034006094 DNA binding residues [nucleotide binding] 565034006095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 565034006096 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 565034006097 active site 565034006098 phosphorylation site [posttranslational modification] 565034006099 intermolecular recognition site; other site 565034006100 dimerization interface [polypeptide binding]; other site 565034006101 primosome assembly protein PriA; Validated; Region: PRK05580 565034006102 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565034006103 ATP binding site [chemical binding]; other site 565034006104 putative Mg++ binding site [ion binding]; other site 565034006105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565034006106 ATP-binding site [chemical binding]; other site 565034006107 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 565034006108 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 565034006109 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 565034006110 23S rRNA interface [nucleotide binding]; other site 565034006111 L3 interface [polypeptide binding]; other site 565034006112 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565034006113 pantoate--beta-alanine ligase; Region: panC; TIGR00018 565034006114 active site 565034006115 nucleotide binding site [chemical binding]; other site 565034006116 HIGH motif; other site 565034006117 KMSKS motif; other site 565034006118 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 565034006119 Outer membrane efflux protein; Region: OEP; pfam02321 565034006120 Outer membrane efflux protein; Region: OEP; pfam02321 565034006121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565034006122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565034006123 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 565034006124 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 565034006125 anti sigma factor interaction site; other site 565034006126 regulatory phosphorylation site [posttranslational modification]; other site 565034006127 ATP synthase A chain; Region: ATP-synt_A; cl00413 565034006128 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 565034006129 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 565034006130 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 565034006131 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 565034006132 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 565034006133 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 565034006134 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 565034006135 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 565034006136 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 565034006137 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 565034006138 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 565034006139 beta subunit interaction interface [polypeptide binding]; other site 565034006140 Walker A motif; other site 565034006141 ATP binding site [chemical binding]; other site 565034006142 Walker B motif; other site 565034006143 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 565034006144 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 565034006145 core domain interface [polypeptide binding]; other site 565034006146 delta subunit interface [polypeptide binding]; other site 565034006147 epsilon subunit interface [polypeptide binding]; other site 565034006148 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034006149 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006150 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006151 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006152 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006153 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006154 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006155 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006156 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006157 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006158 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 565034006159 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034006160 active site 565034006161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034006162 Radical SAM superfamily; Region: Radical_SAM; pfam04055 565034006163 FeS/SAM binding site; other site 565034006164 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 565034006165 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 565034006166 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 565034006167 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 565034006168 active site turn [active] 565034006169 phosphorylation site [posttranslational modification] 565034006170 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 565034006171 HPr interaction site; other site 565034006172 glycerol kinase (GK) interaction site [polypeptide binding]; other site 565034006173 active site 565034006174 phosphorylation site [posttranslational modification] 565034006175 Cache domain; Region: Cache_1; pfam02743 565034006176 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034006177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034006178 dimer interface [polypeptide binding]; other site 565034006179 putative CheW interface [polypeptide binding]; other site 565034006180 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 565034006181 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 565034006182 Protein of unknown function, DUF486; Region: DUF486; cl01236 565034006183 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 565034006184 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 565034006185 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 565034006186 active site 565034006187 Rubrerythrin [Energy production and conversion]; Region: COG1592 565034006188 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 565034006189 binuclear metal center [ion binding]; other site 565034006190 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 565034006191 iron binding site [ion binding]; other site 565034006192 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 565034006193 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 565034006194 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 565034006195 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 565034006196 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 565034006197 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 565034006198 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 565034006199 RNA/DNA hybrid binding site [nucleotide binding]; other site 565034006200 active site 565034006201 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034006202 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565034006203 active site 565034006204 motif I; other site 565034006205 motif II; other site 565034006206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034006207 trigger factor; Region: tig; TIGR00115 565034006208 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 565034006209 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 565034006210 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 565034006211 oligomer interface [polypeptide binding]; other site 565034006212 active site residues [active] 565034006213 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 565034006214 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 565034006215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034006216 Walker A motif; other site 565034006217 ATP binding site [chemical binding]; other site 565034006218 Walker B motif; other site 565034006219 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 565034006220 elongation factor P; Validated; Region: PRK00529 565034006221 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 565034006222 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 565034006223 RNA binding site [nucleotide binding]; other site 565034006224 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 565034006225 RNA binding site [nucleotide binding]; other site 565034006226 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034006227 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034006228 peptide binding site [polypeptide binding]; other site 565034006229 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034006230 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034006231 peptide binding site [polypeptide binding]; other site 565034006232 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 565034006233 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 565034006234 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 565034006235 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 565034006236 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 565034006237 active site 565034006238 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 565034006239 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 565034006240 Rubredoxin [Energy production and conversion]; Region: COG1773 565034006241 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 565034006242 iron binding site [ion binding]; other site 565034006243 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 565034006244 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 565034006245 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 565034006246 peptide chain release factor 1; Validated; Region: prfA; PRK00591 565034006247 This domain is found in peptide chain release factors; Region: PCRF; smart00937 565034006248 RF-1 domain; Region: RF-1; pfam00472 565034006249 spiro-SPASM protein; Region: spiroSPASM; TIGR04321 565034006250 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 565034006251 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 565034006252 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 565034006253 active site 565034006254 Substrate binding site; other site 565034006255 Mg++ binding site; other site 565034006256 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 565034006257 putative trimer interface [polypeptide binding]; other site 565034006258 putative CoA binding site [chemical binding]; other site 565034006259 DJ-1 family protein; Region: not_thiJ; TIGR01383 565034006260 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 565034006261 conserved cys residue [active] 565034006262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034006263 TPR motif; other site 565034006264 TPR repeat; Region: TPR_11; pfam13414 565034006265 binding surface 565034006266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034006267 binding surface 565034006268 TPR motif; other site 565034006269 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 565034006270 active site 565034006271 intersubunit interface [polypeptide binding]; other site 565034006272 catalytic residue [active] 565034006273 Glucuronate isomerase; Region: UxaC; pfam02614 565034006274 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 565034006275 mannonate dehydratase; Provisional; Region: PRK03906 565034006276 mannonate dehydratase; Region: uxuA; TIGR00695 565034006277 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 565034006278 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 565034006279 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 565034006280 MFS/sugar transport protein; Region: MFS_2; pfam13347 565034006281 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 565034006282 beta-D-glucuronidase; Provisional; Region: PRK10150 565034006283 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 565034006284 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 565034006285 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 565034006286 Transcriptional regulators [Transcription]; Region: GntR; COG1802 565034006287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565034006288 DNA-binding site [nucleotide binding]; DNA binding site 565034006289 FCD domain; Region: FCD; pfam07729 565034006290 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 565034006291 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 565034006292 substrate binding site [chemical binding]; other site 565034006293 ATP binding site [chemical binding]; other site 565034006294 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 565034006295 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 565034006296 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 565034006297 Predicted permeases [General function prediction only]; Region: COG0701 565034006298 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 565034006299 Sodium Bile acid symporter family; Region: SBF; cl17470 565034006300 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 565034006301 dimerization interface [polypeptide binding]; other site 565034006302 putative DNA binding site [nucleotide binding]; other site 565034006303 putative Zn2+ binding site [ion binding]; other site 565034006304 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 565034006305 active site 565034006306 catalytic residues [active] 565034006307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034006308 S-adenosylmethionine binding site [chemical binding]; other site 565034006309 Rubrerythrin [Energy production and conversion]; Region: COG1592 565034006310 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 565034006311 dinuclear metal binding motif [ion binding]; other site 565034006312 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 565034006313 iron binding site [ion binding]; other site 565034006314 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 565034006315 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 565034006316 putative NAD(P) binding site [chemical binding]; other site 565034006317 putative substrate binding site [chemical binding]; other site 565034006318 catalytic Zn binding site [ion binding]; other site 565034006319 structural Zn binding site [ion binding]; other site 565034006320 dimer interface [polypeptide binding]; other site 565034006321 YcfA-like protein; Region: YcfA; pfam07927 565034006322 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 565034006323 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 565034006324 HIGH motif; other site 565034006325 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 565034006326 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565034006327 active site 565034006328 KMSKS motif; other site 565034006329 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 565034006330 tRNA binding surface [nucleotide binding]; other site 565034006331 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 565034006332 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 565034006333 Predicted ATPases [General function prediction only]; Region: COG1106 565034006334 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 565034006335 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 565034006336 catalytic residues [active] 565034006337 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 565034006338 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 565034006339 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 565034006340 active site 565034006341 TPR repeat; Region: TPR_11; pfam13414 565034006342 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 565034006343 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 565034006344 L-serine binding site [chemical binding]; other site 565034006345 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 565034006346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 565034006347 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 565034006348 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006349 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006350 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006351 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 565034006352 TrkA-N domain; Region: TrkA_N; pfam02254 565034006353 TrkA-C domain; Region: TrkA_C; pfam02080 565034006354 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 565034006355 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 565034006356 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 565034006357 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 565034006358 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 565034006359 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 565034006360 PilZ domain; Region: PilZ; pfam07238 565034006361 Uncharacterized conserved protein [Function unknown]; Region: COG3339 565034006362 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 565034006363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565034006364 ATP binding site [chemical binding]; other site 565034006365 putative Mg++ binding site [ion binding]; other site 565034006366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565034006367 nucleotide binding region [chemical binding]; other site 565034006368 ATP-binding site [chemical binding]; other site 565034006369 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 565034006370 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 565034006371 active site 565034006372 substrate binding site [chemical binding]; other site 565034006373 metal binding site [ion binding]; metal-binding site 565034006374 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 565034006375 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 565034006376 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 565034006377 Leucine rich repeat; Region: LRR_8; pfam13855 565034006378 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 565034006379 Autotransporter beta-domain; Region: Autotransporter; cl17461 565034006380 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 565034006381 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 565034006382 Late competence development protein ComFB; Region: ComFB; pfam10719 565034006383 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 565034006384 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 565034006385 metal binding site 2 [ion binding]; metal-binding site 565034006386 putative DNA binding helix; other site 565034006387 metal binding site 1 [ion binding]; metal-binding site 565034006388 dimer interface [polypeptide binding]; other site 565034006389 structural Zn2+ binding site [ion binding]; other site 565034006390 Uncharacterized conserved protein [Function unknown]; Region: COG1543 565034006391 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 565034006392 active site 565034006393 substrate binding site [chemical binding]; other site 565034006394 catalytic site [active] 565034006395 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 565034006396 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034006397 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034006398 dimer interface [polypeptide binding]; other site 565034006399 putative CheW interface [polypeptide binding]; other site 565034006400 Cache domain; Region: Cache_1; pfam02743 565034006401 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 565034006402 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034006403 dimer interface [polypeptide binding]; other site 565034006404 putative CheW interface [polypeptide binding]; other site 565034006405 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565034006406 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565034006407 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565034006408 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565034006409 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 565034006410 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565034006411 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 565034006412 Peptidase family M23; Region: Peptidase_M23; pfam01551 565034006413 Acylphosphatase; Region: Acylphosphatase; pfam00708 565034006414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034006415 S-adenosylmethionine binding site [chemical binding]; other site 565034006416 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 565034006417 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 565034006418 active site 565034006419 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 565034006420 Protein export membrane protein; Region: SecD_SecF; cl14618 565034006421 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 565034006422 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 565034006423 substrate binding site [chemical binding]; other site 565034006424 dimer interface [polypeptide binding]; other site 565034006425 ATP binding site [chemical binding]; other site 565034006426 LrgB-like family; Region: LrgB; pfam04172 565034006427 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 565034006428 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 565034006429 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 565034006430 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 565034006431 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 565034006432 putative homodimer interface [polypeptide binding]; other site 565034006433 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 565034006434 heterodimer interface [polypeptide binding]; other site 565034006435 homodimer interface [polypeptide binding]; other site 565034006436 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 565034006437 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 565034006438 23S rRNA interface [nucleotide binding]; other site 565034006439 L7/L12 interface [polypeptide binding]; other site 565034006440 putative thiostrepton binding site; other site 565034006441 L25 interface [polypeptide binding]; other site 565034006442 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 565034006443 mRNA/rRNA interface [nucleotide binding]; other site 565034006444 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 565034006445 23S rRNA interface [nucleotide binding]; other site 565034006446 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 565034006447 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 565034006448 core dimer interface [polypeptide binding]; other site 565034006449 peripheral dimer interface [polypeptide binding]; other site 565034006450 L10 interface [polypeptide binding]; other site 565034006451 L11 interface [polypeptide binding]; other site 565034006452 putative EF-Tu interaction site [polypeptide binding]; other site 565034006453 putative EF-G interaction site [polypeptide binding]; other site 565034006454 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 565034006455 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 565034006456 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 565034006457 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 565034006458 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 565034006459 RPB10 interaction site [polypeptide binding]; other site 565034006460 RPB1 interaction site [polypeptide binding]; other site 565034006461 RPB11 interaction site [polypeptide binding]; other site 565034006462 RPB3 interaction site [polypeptide binding]; other site 565034006463 RPB12 interaction site [polypeptide binding]; other site 565034006464 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 565034006465 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 565034006466 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 565034006467 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 565034006468 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 565034006469 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 565034006470 cleft; other site 565034006471 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 565034006472 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 565034006473 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 565034006474 DNA binding site [nucleotide binding] 565034006475 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 565034006476 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 565034006477 gating phenylalanine in ion channel; other site 565034006478 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 565034006479 histidinol dehydrogenase; Region: hisD; TIGR00069 565034006480 NAD binding site [chemical binding]; other site 565034006481 dimerization interface [polypeptide binding]; other site 565034006482 product binding site; other site 565034006483 substrate binding site [chemical binding]; other site 565034006484 zinc binding site [ion binding]; other site 565034006485 catalytic residues [active] 565034006486 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 565034006487 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 565034006488 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 565034006489 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 565034006490 motif 1; other site 565034006491 dimer interface [polypeptide binding]; other site 565034006492 active site 565034006493 motif 2; other site 565034006494 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 565034006495 active site 565034006496 motif 3; other site 565034006497 RNB domain; Region: RNB; pfam00773 565034006498 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 565034006499 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 565034006500 RNA binding site [nucleotide binding]; other site 565034006501 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 565034006502 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 565034006503 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 565034006504 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565034006505 RNA binding surface [nucleotide binding]; other site 565034006506 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 565034006507 active site 565034006508 uracil binding [chemical binding]; other site 565034006509 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 565034006510 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 565034006511 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 565034006512 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 565034006513 homodimer interface [polypeptide binding]; other site 565034006514 metal binding site [ion binding]; metal-binding site 565034006515 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 565034006516 homodimer interface [polypeptide binding]; other site 565034006517 active site 565034006518 putative chemical substrate binding site [chemical binding]; other site 565034006519 metal binding site [ion binding]; metal-binding site 565034006520 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 565034006521 catalytic residues [active] 565034006522 dimer interface [polypeptide binding]; other site 565034006523 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006524 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006525 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565034006526 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565034006527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034006528 Walker A/P-loop; other site 565034006529 ATP binding site [chemical binding]; other site 565034006530 Q-loop/lid; other site 565034006531 ABC transporter signature motif; other site 565034006532 Walker B; other site 565034006533 D-loop; other site 565034006534 H-loop/switch region; other site 565034006535 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 565034006536 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 565034006537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034006538 Walker A/P-loop; other site 565034006539 ATP binding site [chemical binding]; other site 565034006540 Q-loop/lid; other site 565034006541 ABC transporter signature motif; other site 565034006542 Walker B; other site 565034006543 D-loop; other site 565034006544 H-loop/switch region; other site 565034006545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565034006546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565034006547 Protein of unknown function (DUF454); Region: DUF454; cl01063 565034006548 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 565034006549 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 565034006550 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 565034006551 putative FMN binding site [chemical binding]; other site 565034006552 NADPH bind site [chemical binding]; other site 565034006553 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 565034006554 YcaO-like family; Region: YcaO; pfam02624 565034006555 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 565034006556 CAAX protease self-immunity; Region: Abi; pfam02517 565034006557 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 565034006558 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 565034006559 Walker A/P-loop; other site 565034006560 ATP binding site [chemical binding]; other site 565034006561 Q-loop/lid; other site 565034006562 ABC transporter signature motif; other site 565034006563 Walker B; other site 565034006564 D-loop; other site 565034006565 H-loop/switch region; other site 565034006566 ABC-2 type transporter; Region: ABC2_membrane; cl17235 565034006567 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 565034006568 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565034006569 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 565034006570 Walker A/P-loop; other site 565034006571 ATP binding site [chemical binding]; other site 565034006572 Q-loop/lid; other site 565034006573 ABC transporter signature motif; other site 565034006574 Walker B; other site 565034006575 D-loop; other site 565034006576 H-loop/switch region; other site 565034006577 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 565034006578 FtsX-like permease family; Region: FtsX; pfam02687 565034006579 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 565034006580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034006581 Walker A/P-loop; other site 565034006582 ATP binding site [chemical binding]; other site 565034006583 Q-loop/lid; other site 565034006584 ABC transporter signature motif; other site 565034006585 Walker B; other site 565034006586 D-loop; other site 565034006587 H-loop/switch region; other site 565034006588 TOBE domain; Region: TOBE_2; pfam08402 565034006589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034006590 dimer interface [polypeptide binding]; other site 565034006591 conserved gate region; other site 565034006592 putative PBP binding loops; other site 565034006593 ABC-ATPase subunit interface; other site 565034006594 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 565034006595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034006596 dimer interface [polypeptide binding]; other site 565034006597 conserved gate region; other site 565034006598 putative PBP binding loops; other site 565034006599 ABC-ATPase subunit interface; other site 565034006600 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 565034006601 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 565034006602 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 565034006603 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 565034006604 active site 565034006605 metal binding site [ion binding]; metal-binding site 565034006606 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 565034006607 phosphopentomutase; Provisional; Region: PRK05362 565034006608 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 565034006609 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 565034006610 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 565034006611 active site 565034006612 trimer interface [polypeptide binding]; other site 565034006613 allosteric site; other site 565034006614 active site lid [active] 565034006615 hexamer (dimer of trimers) interface [polypeptide binding]; other site 565034006616 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 565034006617 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 565034006618 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 565034006619 dimer interface [polypeptide binding]; other site 565034006620 active site 565034006621 glycine-pyridoxal phosphate binding site [chemical binding]; other site 565034006622 folate binding site [chemical binding]; other site 565034006623 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 565034006624 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 565034006625 Protein of unknown function (DUF454); Region: DUF454; cl01063 565034006626 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 565034006627 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 565034006628 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 565034006629 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 565034006630 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 565034006631 Potassium binding sites [ion binding]; other site 565034006632 Cesium cation binding sites [ion binding]; other site 565034006633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034006634 TPR motif; other site 565034006635 TPR repeat; Region: TPR_11; pfam13414 565034006636 binding surface 565034006637 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034006638 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 565034006639 Carbon starvation protein CstA; Region: CstA; pfam02554 565034006640 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 565034006641 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 565034006642 active site 565034006643 dimerization interface [polypeptide binding]; other site 565034006644 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 565034006645 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 565034006646 DctM-like transporters; Region: DctM; pfam06808 565034006647 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 565034006648 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 565034006649 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 565034006650 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 565034006651 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 565034006652 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 565034006653 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 565034006654 putative homodimer interface [polypeptide binding]; other site 565034006655 putative active site pocket [active] 565034006656 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 565034006657 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 565034006658 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 565034006659 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 565034006660 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 565034006661 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 565034006662 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 565034006663 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 565034006664 ATP-grasp domain; Region: ATP-grasp_4; cl17255 565034006665 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 565034006666 IMP binding site; other site 565034006667 dimer interface [polypeptide binding]; other site 565034006668 interdomain contacts; other site 565034006669 partial ornithine binding site; other site 565034006670 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 565034006671 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 565034006672 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 565034006673 catalytic site [active] 565034006674 subunit interface [polypeptide binding]; other site 565034006675 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 565034006676 SurA N-terminal domain; Region: SurA_N; pfam09312 565034006677 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 565034006678 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 565034006679 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 565034006680 B12 binding site [chemical binding]; other site 565034006681 Flagellin N-methylase; Region: FliB; cl00497 565034006682 Transcriptional regulators [Transcription]; Region: MarR; COG1846 565034006683 MarR family; Region: MarR_2; pfam12802 565034006684 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 565034006685 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 565034006686 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 565034006687 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 565034006688 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 565034006689 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006690 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006691 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006692 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006693 AAA domain; Region: AAA_21; pfam13304 565034006694 recombination protein F; Reviewed; Region: recF; PRK00064 565034006695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034006696 Walker A/P-loop; other site 565034006697 ATP binding site [chemical binding]; other site 565034006698 Q-loop/lid; other site 565034006699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034006700 ABC transporter signature motif; other site 565034006701 Walker B; other site 565034006702 D-loop; other site 565034006703 H-loop/switch region; other site 565034006704 S-adenosylmethionine synthetase; Validated; Region: PRK05250 565034006705 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 565034006706 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 565034006707 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 565034006708 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 565034006709 metal ion-dependent adhesion site (MIDAS); other site 565034006710 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 565034006711 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565034006712 active site 565034006713 nucleotide binding site [chemical binding]; other site 565034006714 HIGH motif; other site 565034006715 KMSKS motif; other site 565034006716 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 565034006717 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 565034006718 Chorismate mutase type II; Region: CM_2; smart00830 565034006719 prephenate dehydratase; Provisional; Region: PRK11898 565034006720 Prephenate dehydratase; Region: PDT; pfam00800 565034006721 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 565034006722 putative L-Phe binding site [chemical binding]; other site 565034006723 shikimate kinase; Provisional; Region: PRK13947 565034006724 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 565034006725 ADP binding site [chemical binding]; other site 565034006726 magnesium binding site [ion binding]; other site 565034006727 putative shikimate binding site; other site 565034006728 Protein of unknown function (DUF554); Region: DUF554; pfam04474 565034006729 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 565034006730 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565034006731 active site 565034006732 phosphorylation site [posttranslational modification] 565034006733 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 565034006734 Putative zinc ribbon domain; Region: DUF164; pfam02591 565034006735 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 565034006736 elongation factor G; Reviewed; Region: PRK12740 565034006737 G1 box; other site 565034006738 putative GEF interaction site [polypeptide binding]; other site 565034006739 GTP/Mg2+ binding site [chemical binding]; other site 565034006740 Switch I region; other site 565034006741 G2 box; other site 565034006742 G3 box; other site 565034006743 Switch II region; other site 565034006744 G4 box; other site 565034006745 G5 box; other site 565034006746 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 565034006747 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 565034006748 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 565034006749 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 565034006750 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 565034006751 active site 565034006752 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 565034006753 putative substrate binding pocket [chemical binding]; other site 565034006754 AC domain interface; other site 565034006755 catalytic triad [active] 565034006756 AB domain interface; other site 565034006757 interchain disulfide; other site 565034006758 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 565034006759 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 565034006760 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 565034006761 dimerization interface [polypeptide binding]; other site 565034006762 ATP binding site [chemical binding]; other site 565034006763 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 565034006764 dimerization interface [polypeptide binding]; other site 565034006765 ATP binding site [chemical binding]; other site 565034006766 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 565034006767 putative active site [active] 565034006768 catalytic triad [active] 565034006769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 565034006770 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565034006771 active site 565034006772 motif I; other site 565034006773 motif II; other site 565034006774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034006775 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 565034006776 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 565034006777 metal binding site [ion binding]; metal-binding site 565034006778 dimer interface [polypeptide binding]; other site 565034006779 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034006780 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034006781 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034006782 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006783 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006784 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 565034006785 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 565034006786 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 565034006787 dimerization domain swap beta strand [polypeptide binding]; other site 565034006788 regulatory protein interface [polypeptide binding]; other site 565034006789 active site 565034006790 regulatory phosphorylation site [posttranslational modification]; other site 565034006791 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 565034006792 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 565034006793 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 565034006794 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 565034006795 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 565034006796 HEAT repeats; Region: HEAT_2; pfam13646 565034006797 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 565034006798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034006799 Walker A/P-loop; other site 565034006800 ATP binding site [chemical binding]; other site 565034006801 Q-loop/lid; other site 565034006802 ABC transporter signature motif; other site 565034006803 Walker B; other site 565034006804 D-loop; other site 565034006805 H-loop/switch region; other site 565034006806 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 565034006807 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006808 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006809 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006810 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006811 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006812 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006813 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 565034006814 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 565034006815 TPR repeat; Region: TPR_11; pfam13414 565034006816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034006817 binding surface 565034006818 TPR motif; other site 565034006819 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 565034006820 Methyltransferase domain; Region: Methyltransf_31; pfam13847 565034006821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034006822 S-adenosylmethionine binding site [chemical binding]; other site 565034006823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 565034006824 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 565034006825 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 565034006826 6-phosphofructokinase; Provisional; Region: PRK03202 565034006827 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 565034006828 active site 565034006829 ADP/pyrophosphate binding site [chemical binding]; other site 565034006830 dimerization interface [polypeptide binding]; other site 565034006831 allosteric effector site; other site 565034006832 fructose-1,6-bisphosphate binding site; other site 565034006833 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 565034006834 MgtE intracellular N domain; Region: MgtE_N; smart00924 565034006835 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 565034006836 Divalent cation transporter; Region: MgtE; pfam01769 565034006837 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 565034006838 Na2 binding site [ion binding]; other site 565034006839 putative substrate binding site 1 [chemical binding]; other site 565034006840 Na binding site 1 [ion binding]; other site 565034006841 putative substrate binding site 2 [chemical binding]; other site 565034006842 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 565034006843 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 565034006844 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 565034006845 XPC-binding domain; Region: XPC-binding; pfam09280 565034006846 Predicted transcriptional regulator [Transcription]; Region: COG1959 565034006847 Transcriptional regulator; Region: Rrf2; pfam02082 565034006848 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565034006849 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034006850 ligand binding site [chemical binding]; other site 565034006851 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 565034006852 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 565034006853 Na binding site [ion binding]; other site 565034006854 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 565034006855 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 565034006856 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 565034006857 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 565034006858 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 565034006859 catalytic residue [active] 565034006860 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 565034006861 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 565034006862 CPxP motif; other site 565034006863 DsrE/DsrF-like family; Region: DrsE; pfam02635 565034006864 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034006865 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034006866 putative CheW interface [polypeptide binding]; other site 565034006867 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 565034006868 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034006869 putative CheW interface [polypeptide binding]; other site 565034006870 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565034006871 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 565034006872 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 565034006873 Catalytic site [active] 565034006874 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 565034006875 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 565034006876 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 565034006877 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 565034006878 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 565034006879 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 565034006880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565034006881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565034006882 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 565034006883 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 565034006884 active site 565034006885 dimer interface [polypeptide binding]; other site 565034006886 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 565034006887 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565034006888 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 565034006889 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 565034006890 Phosphotransferase enzyme family; Region: APH; pfam01636 565034006891 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 565034006892 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 565034006893 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 565034006894 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 565034006895 5S rRNA interface [nucleotide binding]; other site 565034006896 CTC domain interface [polypeptide binding]; other site 565034006897 L16 interface [polypeptide binding]; other site 565034006898 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 565034006899 putative active site [active] 565034006900 catalytic residue [active] 565034006901 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 565034006902 putative active site [active] 565034006903 catalytic residue [active] 565034006904 Uncharacterized conserved protein [Function unknown]; Region: COG1359 565034006905 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 565034006906 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 565034006907 Domain of unknown function (DUF386); Region: DUF386; cl01047 565034006908 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 565034006909 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 565034006910 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 565034006911 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 565034006912 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 565034006913 4Fe-4S binding domain; Region: Fer4; pfam00037 565034006914 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 565034006915 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 565034006916 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 565034006917 dimer interface [polypeptide binding]; other site 565034006918 [2Fe-2S] cluster binding site [ion binding]; other site 565034006919 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 565034006920 SLBB domain; Region: SLBB; pfam10531 565034006921 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 565034006922 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 565034006923 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 565034006924 putative dimer interface [polypeptide binding]; other site 565034006925 [2Fe-2S] cluster binding site [ion binding]; other site 565034006926 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 565034006927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 565034006928 Walker A/P-loop; other site 565034006929 ATP binding site [chemical binding]; other site 565034006930 AAA domain; Region: AAA_21; pfam13304 565034006931 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 565034006932 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 565034006933 purine monophosphate binding site [chemical binding]; other site 565034006934 dimer interface [polypeptide binding]; other site 565034006935 putative catalytic residues [active] 565034006936 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 565034006937 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 565034006938 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 565034006939 active site residue [active] 565034006940 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 565034006941 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034006942 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034006943 peptide binding site [polypeptide binding]; other site 565034006944 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 565034006945 methionine cluster; other site 565034006946 active site 565034006947 phosphorylation site [posttranslational modification] 565034006948 metal binding site [ion binding]; metal-binding site 565034006949 Uncharacterized conserved protein [Function unknown]; Region: COG3589 565034006950 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 565034006951 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 565034006952 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 565034006953 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 565034006954 active site 565034006955 P-loop; other site 565034006956 phosphorylation site [posttranslational modification] 565034006957 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 565034006958 HTH domain; Region: HTH_11; pfam08279 565034006959 Mga helix-turn-helix domain; Region: Mga; pfam05043 565034006960 PRD domain; Region: PRD; pfam00874 565034006961 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 565034006962 active site 565034006963 P-loop; other site 565034006964 phosphorylation site [posttranslational modification] 565034006965 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 565034006966 active site 565034006967 phosphorylation site [posttranslational modification] 565034006968 PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381 565034006969 dimerization domain swap beta strand [polypeptide binding]; other site 565034006970 regulatory protein interface [polypeptide binding]; other site 565034006971 active site 565034006972 regulatory phosphorylation site [posttranslational modification]; other site 565034006973 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 565034006974 Methyltransferase domain; Region: Methyltransf_23; pfam13489 565034006975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 565034006976 S-adenosylmethionine binding site [chemical binding]; other site 565034006977 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 565034006978 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 565034006979 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 565034006980 catalytic triad [active] 565034006981 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 565034006982 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 565034006983 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 565034006984 active site 565034006985 substrate binding site [chemical binding]; other site 565034006986 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 565034006987 FMN binding site [chemical binding]; other site 565034006988 putative catalytic residues [active] 565034006989 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034006990 TPR motif; other site 565034006991 binding surface 565034006992 TPR repeat; Region: TPR_11; pfam13414 565034006993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034006994 binding surface 565034006995 TPR repeat; Region: TPR_11; pfam13414 565034006996 TPR motif; other site 565034006997 TPR repeat; Region: TPR_11; pfam13414 565034006998 TPR repeat; Region: TPR_11; pfam13414 565034006999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007000 binding surface 565034007001 TPR motif; other site 565034007002 TPR repeat; Region: TPR_11; pfam13414 565034007003 TPR repeat; Region: TPR_11; pfam13414 565034007004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007005 binding surface 565034007006 TPR motif; other site 565034007007 TPR repeat; Region: TPR_11; pfam13414 565034007008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007009 binding surface 565034007010 TPR motif; other site 565034007011 TPR repeat; Region: TPR_11; pfam13414 565034007012 TPR repeat; Region: TPR_11; pfam13414 565034007013 TPR repeat; Region: TPR_11; pfam13414 565034007014 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007015 binding surface 565034007016 TPR motif; other site 565034007017 TPR repeat; Region: TPR_11; pfam13414 565034007018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007019 binding surface 565034007020 TPR motif; other site 565034007021 TPR repeat; Region: TPR_11; pfam13414 565034007022 TPR repeat; Region: TPR_11; pfam13414 565034007023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007024 binding surface 565034007025 TPR motif; other site 565034007026 TPR repeat; Region: TPR_11; pfam13414 565034007027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007028 TPR motif; other site 565034007029 binding surface 565034007030 TPR repeat; Region: TPR_11; pfam13414 565034007031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007032 TPR motif; other site 565034007033 TPR repeat; Region: TPR_11; pfam13414 565034007034 binding surface 565034007035 TPR repeat; Region: TPR_11; pfam13414 565034007036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007037 binding surface 565034007038 TPR motif; other site 565034007039 TPR repeat; Region: TPR_11; pfam13414 565034007040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007041 binding surface 565034007042 TPR motif; other site 565034007043 TPR repeat; Region: TPR_11; pfam13414 565034007044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007045 binding surface 565034007046 TPR motif; other site 565034007047 TPR repeat; Region: TPR_11; pfam13414 565034007048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007049 binding surface 565034007050 TPR repeat; Region: TPR_11; pfam13414 565034007051 TPR motif; other site 565034007052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007053 binding surface 565034007054 TPR motif; other site 565034007055 TPR repeat; Region: TPR_11; pfam13414 565034007056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007057 binding surface 565034007058 TPR motif; other site 565034007059 TPR repeat; Region: TPR_11; pfam13414 565034007060 TPR repeat; Region: TPR_11; pfam13414 565034007061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007062 binding surface 565034007063 TPR motif; other site 565034007064 TPR repeat; Region: TPR_11; pfam13414 565034007065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007066 binding surface 565034007067 TPR repeat; Region: TPR_11; pfam13414 565034007068 TPR motif; other site 565034007069 TPR repeat; Region: TPR_11; pfam13414 565034007070 magnesium-transporting ATPase; Provisional; Region: PRK15122 565034007071 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 565034007072 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565034007073 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 565034007074 Soluble P-type ATPase [General function prediction only]; Region: COG4087 565034007075 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 565034007076 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 565034007077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034007078 dimer interface [polypeptide binding]; other site 565034007079 conserved gate region; other site 565034007080 putative PBP binding loops; other site 565034007081 ABC-ATPase subunit interface; other site 565034007082 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 565034007083 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 565034007084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034007085 dimer interface [polypeptide binding]; other site 565034007086 conserved gate region; other site 565034007087 putative PBP binding loops; other site 565034007088 ABC-ATPase subunit interface; other site 565034007089 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 565034007090 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 565034007091 Walker A/P-loop; other site 565034007092 ATP binding site [chemical binding]; other site 565034007093 Q-loop/lid; other site 565034007094 ABC transporter signature motif; other site 565034007095 Walker B; other site 565034007096 D-loop; other site 565034007097 H-loop/switch region; other site 565034007098 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 565034007099 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 565034007100 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 565034007101 Walker A/P-loop; other site 565034007102 ATP binding site [chemical binding]; other site 565034007103 Q-loop/lid; other site 565034007104 ABC transporter signature motif; other site 565034007105 Walker B; other site 565034007106 D-loop; other site 565034007107 H-loop/switch region; other site 565034007108 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 565034007109 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 565034007110 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565034007111 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 565034007112 peptide binding site [polypeptide binding]; other site 565034007113 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 565034007114 MarR family; Region: MarR_2; pfam12802 565034007115 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 565034007116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 565034007117 active site 565034007118 motif I; other site 565034007119 motif II; other site 565034007120 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 565034007121 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 565034007122 putative binding surface; other site 565034007123 active site 565034007124 P2 response regulator binding domain; Region: P2; pfam07194 565034007125 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 565034007126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565034007127 ATP binding site [chemical binding]; other site 565034007128 Mg2+ binding site [ion binding]; other site 565034007129 G-X-G motif; other site 565034007130 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 565034007131 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 565034007132 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 565034007133 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 565034007134 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 565034007135 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 565034007136 putative active site [active] 565034007137 putative metal binding site [ion binding]; other site 565034007138 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 565034007139 META domain; Region: META; pfam03724 565034007140 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 565034007141 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 565034007142 TM-ABC transporter signature motif; other site 565034007143 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 565034007144 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 565034007145 Walker A/P-loop; other site 565034007146 ATP binding site [chemical binding]; other site 565034007147 Q-loop/lid; other site 565034007148 ABC transporter signature motif; other site 565034007149 Walker B; other site 565034007150 D-loop; other site 565034007151 H-loop/switch region; other site 565034007152 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 565034007153 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 565034007154 ligand binding site [chemical binding]; other site 565034007155 calcium binding site [ion binding]; other site 565034007156 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 565034007157 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 565034007158 ligand binding site [chemical binding]; other site 565034007159 calcium binding site [ion binding]; other site 565034007160 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 565034007161 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 565034007162 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 565034007163 active site 565034007164 dimer interface [polypeptide binding]; other site 565034007165 metal binding site [ion binding]; metal-binding site 565034007166 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 565034007167 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 565034007168 heat shock protein 90; Provisional; Region: PRK05218 565034007169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565034007170 ATP binding site [chemical binding]; other site 565034007171 Mg2+ binding site [ion binding]; other site 565034007172 G-X-G motif; other site 565034007173 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 565034007174 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 565034007175 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 565034007176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 565034007177 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 565034007178 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 565034007179 DNA binding residues [nucleotide binding] 565034007180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 565034007181 Coenzyme A binding pocket [chemical binding]; other site 565034007182 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 565034007183 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 565034007184 substrate binding pocket [chemical binding]; other site 565034007185 membrane-bound complex binding site; other site 565034007186 hinge residues; other site 565034007187 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 565034007188 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 565034007189 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 565034007190 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 565034007191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034007192 dimer interface [polypeptide binding]; other site 565034007193 conserved gate region; other site 565034007194 putative PBP binding loops; other site 565034007195 ABC-ATPase subunit interface; other site 565034007196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 565034007197 dimer interface [polypeptide binding]; other site 565034007198 conserved gate region; other site 565034007199 putative PBP binding loops; other site 565034007200 ABC-ATPase subunit interface; other site 565034007201 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 565034007202 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 565034007203 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 565034007204 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 565034007205 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 565034007206 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 565034007207 YcfA-like protein; Region: YcfA; cl00752 565034007208 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 565034007209 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 565034007210 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 565034007211 DNA methylase; Region: N6_N4_Mtase; cl17433 565034007212 GMP synthase; Reviewed; Region: guaA; PRK00074 565034007213 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 565034007214 AMP/PPi binding site [chemical binding]; other site 565034007215 candidate oxyanion hole; other site 565034007216 catalytic triad [active] 565034007217 potential glutamine specificity residues [chemical binding]; other site 565034007218 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 565034007219 ATP Binding subdomain [chemical binding]; other site 565034007220 Ligand Binding sites [chemical binding]; other site 565034007221 Dimerization subdomain; other site 565034007222 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 565034007223 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 565034007224 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 565034007225 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 565034007226 dimer interface [polypeptide binding]; other site 565034007227 putative CheW interface [polypeptide binding]; other site 565034007228 Rod binding protein; Region: Rod-binding; pfam10135 565034007229 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 565034007230 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 565034007231 DNA polymerase I; Provisional; Region: PRK05755 565034007232 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 565034007233 active site 565034007234 metal binding site 1 [ion binding]; metal-binding site 565034007235 putative 5' ssDNA interaction site; other site 565034007236 metal binding site 3; metal-binding site 565034007237 metal binding site 2 [ion binding]; metal-binding site 565034007238 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 565034007239 putative DNA binding site [nucleotide binding]; other site 565034007240 putative metal binding site [ion binding]; other site 565034007241 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 565034007242 active site 565034007243 catalytic site [active] 565034007244 substrate binding site [chemical binding]; other site 565034007245 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 565034007246 active site 565034007247 DNA binding site [nucleotide binding] 565034007248 catalytic site [active] 565034007249 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 565034007250 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 565034007251 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 565034007252 active site 565034007253 metal binding site [ion binding]; metal-binding site 565034007254 DNA topoisomerase I; Validated; Region: PRK05582 565034007255 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 565034007256 active site 565034007257 interdomain interaction site; other site 565034007258 putative metal-binding site [ion binding]; other site 565034007259 nucleotide binding site [chemical binding]; other site 565034007260 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 565034007261 domain I; other site 565034007262 DNA binding groove [nucleotide binding] 565034007263 phosphate binding site [ion binding]; other site 565034007264 domain II; other site 565034007265 domain III; other site 565034007266 nucleotide binding site [chemical binding]; other site 565034007267 catalytic site [active] 565034007268 domain IV; other site 565034007269 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 565034007270 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 565034007271 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 565034007272 DNA protecting protein DprA; Region: dprA; TIGR00732 565034007273 TPR repeat; Region: TPR_11; pfam13414 565034007274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007275 TPR motif; other site 565034007276 Part of AAA domain; Region: AAA_19; pfam13245 565034007277 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 565034007278 Family description; Region: UvrD_C_2; pfam13538 565034007279 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 565034007280 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 565034007281 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 565034007282 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 565034007283 putative active site [active] 565034007284 Chloramphenicol acetyltransferase; Region: CAT; cl02008 565034007285 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 565034007286 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 565034007287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 565034007288 non-specific DNA binding site [nucleotide binding]; other site 565034007289 salt bridge; other site 565034007290 sequence-specific DNA binding site [nucleotide binding]; other site 565034007291 Putative motility protein; Region: YjfB_motility; pfam14070 565034007292 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 565034007293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 565034007294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 565034007295 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 565034007296 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 565034007297 active site residue [active] 565034007298 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 565034007299 active site residue [active] 565034007300 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 565034007301 putative homotetramer interface [polypeptide binding]; other site 565034007302 putative homodimer interface [polypeptide binding]; other site 565034007303 putative allosteric switch controlling residues; other site 565034007304 putative metal binding site [ion binding]; other site 565034007305 putative homodimer-homodimer interface [polypeptide binding]; other site 565034007306 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 565034007307 active site 565034007308 dimer interface [polypeptide binding]; other site 565034007309 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 565034007310 active site 565034007311 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 565034007312 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 565034007313 heterodimer interface [polypeptide binding]; other site 565034007314 active site 565034007315 FMN binding site [chemical binding]; other site 565034007316 homodimer interface [polypeptide binding]; other site 565034007317 substrate binding site [chemical binding]; other site 565034007318 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 565034007319 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 565034007320 FAD binding pocket [chemical binding]; other site 565034007321 FAD binding motif [chemical binding]; other site 565034007322 phosphate binding motif [ion binding]; other site 565034007323 beta-alpha-beta structure motif; other site 565034007324 NAD binding pocket [chemical binding]; other site 565034007325 Iron coordination center [ion binding]; other site 565034007326 4Fe-4S binding domain; Region: Fer4; pfam00037 565034007327 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 565034007328 von Willebrand factor type A domain; Region: VWA_2; pfam13519 565034007329 metal ion-dependent adhesion site (MIDAS); other site 565034007330 Tetratricopeptide repeat; Region: TPR_12; pfam13424 565034007331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007332 TPR motif; other site 565034007333 binding surface 565034007334 Oxygen tolerance; Region: BatD; pfam13584 565034007335 Tetratricopeptide repeat; Region: TPR_16; pfam13432 565034007336 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 565034007337 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 565034007338 Ligand Binding Site [chemical binding]; other site 565034007339 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 565034007340 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 565034007341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034007342 binding surface 565034007343 TPR motif; other site 565034007344 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 565034007345 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 565034007346 active site 565034007347 Uncharacterized conserved protein [Function unknown]; Region: COG2006 565034007348 Domain of unknown function (DUF362); Region: DUF362; pfam04015 565034007349 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 565034007350 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 565034007351 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 565034007352 active site 565034007353 metal binding site [ion binding]; metal-binding site 565034007354 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 565034007355 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 565034007356 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 565034007357 active site 565034007358 putative substrate binding pocket [chemical binding]; other site 565034007359 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 565034007360 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 565034007361 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 565034007362 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 565034007363 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 565034007364 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 565034007365 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 565034007366 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 565034007367 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 565034007368 active site 565034007369 catalytic tetrad [active] 565034007370 Flagellar protein FliS; Region: FliS; cl00654 565034007371 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 565034007372 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 565034007373 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 565034007374 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 565034007375 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 565034007376 active site 565034007377 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 565034007378 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 565034007379 active site 565034007380 dimer interface [polypeptide binding]; other site 565034007381 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 565034007382 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 565034007383 active site 565034007384 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 565034007385 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 565034007386 putative substrate binding site [chemical binding]; other site 565034007387 putative ATP binding site [chemical binding]; other site 565034007388 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 565034007389 catalytic residues [active] 565034007390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 565034007391 MarR family; Region: MarR_2; pfam12802 565034007392 Predicted membrane protein [Function unknown]; Region: COG2364 565034007393 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 565034007394 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 565034007395 dimer interface [polypeptide binding]; other site 565034007396 active site 565034007397 acyl carrier protein; Provisional; Region: acpP; PRK00982 565034007398 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 565034007399 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 565034007400 NAD(P) binding site [chemical binding]; other site 565034007401 homotetramer interface [polypeptide binding]; other site 565034007402 homodimer interface [polypeptide binding]; other site 565034007403 active site 565034007404 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 565034007405 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 565034007406 active site 565034007407 substrate binding site [chemical binding]; other site 565034007408 metal binding site [ion binding]; metal-binding site 565034007409 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034007410 ligand binding site [chemical binding]; other site 565034007411 flexible hinge region; other site 565034007412 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 565034007413 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 565034007414 ligand binding site [chemical binding]; other site 565034007415 flexible hinge region; other site 565034007416 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 565034007417 Protein of unknown function (DUF721); Region: DUF721; pfam05258 565034007418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 565034007419 binding surface 565034007420 Tetratricopeptide repeat; Region: TPR_16; pfam13432 565034007421 TPR motif; other site 565034007422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 565034007423 binding surface 565034007424 TPR motif; other site 565034007425 TPR repeat; Region: TPR_11; pfam13414 565034007426 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 565034007427 galactokinase; Provisional; Region: PRK05322 565034007428 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 565034007429 peptide chain release factor 2; Provisional; Region: PRK05589 565034007430 This domain is found in peptide chain release factors; Region: PCRF; smart00937 565034007431 RF-1 domain; Region: RF-1; pfam00472 565034007432 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 565034007433 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 565034007434 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 565034007435 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 565034007436 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 565034007437 Walker A/P-loop; other site 565034007438 ATP binding site [chemical binding]; other site 565034007439 Q-loop/lid; other site 565034007440 ABC transporter signature motif; other site 565034007441 Walker B; other site 565034007442 D-loop; other site 565034007443 H-loop/switch region; other site 565034007444 MoxR-like ATPases [General function prediction only]; Region: COG0714 565034007445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 565034007446 Walker A motif; other site 565034007447 ATP binding site [chemical binding]; other site 565034007448 Walker B motif; other site 565034007449 arginine finger; other site 565034007450 hypothetical protein; Provisional; Region: yieM; PRK10997 565034007451 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 565034007452 metal ion-dependent adhesion site (MIDAS); other site 565034007453 ribonuclease III; Reviewed; Region: rnc; PRK00102 565034007454 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 565034007455 dimerization interface [polypeptide binding]; other site 565034007456 active site 565034007457 metal binding site [ion binding]; metal-binding site 565034007458 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 565034007459 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 565034007460 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 565034007461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565034007462 NAD(P) binding site [chemical binding]; other site 565034007463 active site 565034007464 Protein of unknown function (DUF616); Region: DUF616; pfam04765 565034007465 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 565034007466 Rhamnan synthesis protein F; Region: RgpF; pfam05045 565034007467 Rhamnan synthesis protein F; Region: RgpF; pfam05045 565034007468 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 565034007469 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034007470 FeS/SAM binding site; other site 565034007471 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 565034007472 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 565034007473 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034007474 FeS/SAM binding site; other site 565034007475 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 565034007476 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 565034007477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034007478 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 565034007479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034007480 Radical SAM superfamily; Region: Radical_SAM; pfam04055 565034007481 FeS/SAM binding site; other site 565034007482 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 565034007483 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 565034007484 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034007485 FeS/SAM binding site; other site 565034007486 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 565034007487 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034007488 FeS/SAM binding site; other site 565034007489 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 565034007490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 565034007491 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 565034007492 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 565034007493 extended (e) SDRs; Region: SDR_e; cd08946 565034007494 NAD(P) binding site [chemical binding]; other site 565034007495 substrate binding site [chemical binding]; other site 565034007496 active site 565034007497 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 565034007498 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 565034007499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 565034007500 FeS/SAM binding site; other site 565034007501 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 565034007502 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 565034007503 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 565034007504 substrate binding site; other site 565034007505 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 565034007506 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 565034007507 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 565034007508 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 565034007509 Walker B motif; other site 565034007510 CHC2 zinc finger; Region: zf-CHC2; cl17510 565034007511 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 565034007512 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 565034007513 active site 565034007514 metal binding site [ion binding]; metal-binding site 565034007515 interdomain interaction site; other site 565034007516 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 565034007517 active site 565034007518 catalytic residues [active] 565034007519 DNA binding site [nucleotide binding] 565034007520 Int/Topo IB signature motif; other site 565034007521 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 565034007522 GDP-Fucose binding site [chemical binding]; other site 565034007523 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 565034007524 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 565034007525 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 565034007526 NAD binding site [chemical binding]; other site 565034007527 substrate binding site [chemical binding]; other site 565034007528 homodimer interface [polypeptide binding]; other site 565034007529 active site 565034007530 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 565034007531 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 565034007532 substrate binding site; other site 565034007533 tetramer interface; other site 565034007534 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 565034007535 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 565034007536 NADP binding site [chemical binding]; other site 565034007537 active site 565034007538 putative substrate binding site [chemical binding]; other site 565034007539 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 565034007540 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 565034007541 active site 565034007542 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305