-- dump date 20140619_005215 -- class Genbank::misc_feature -- table misc_feature_note -- id note 759914000001 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 759914000002 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 759914000003 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 759914000004 Methyltransferase domain; Region: Methyltransf_24; pfam13578 759914000005 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 759914000006 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 759914000007 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759914000008 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759914000009 Cache domain; Region: Cache_1; pfam02743 759914000010 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 759914000011 HAMP domain; Region: HAMP; pfam00672 759914000012 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914000013 dimer interface [polypeptide binding]; other site 759914000014 putative CheW interface [polypeptide binding]; other site 759914000015 Hemerythrin; Region: Hemerythrin; cd12107 759914000016 Fe binding site [ion binding]; other site 759914000017 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 759914000018 Ribonuclease P; Region: Ribonuclease_P; pfam00825 759914000019 Haemolytic domain; Region: Haemolytic; pfam01809 759914000020 membrane protein insertase; Provisional; Region: PRK01318 759914000021 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 759914000022 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 759914000023 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 759914000024 G-X-X-G motif; other site 759914000025 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 759914000026 RxxxH motif; other site 759914000027 Sporulation and spore germination; Region: Germane; smart00909 759914000028 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914000029 peptide binding site [polypeptide binding]; other site 759914000030 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 759914000031 META domain; Region: META; pfam03724 759914000032 META domain; Region: META; pfam03724 759914000033 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 759914000034 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 759914000035 HSP70 interaction site [polypeptide binding]; other site 759914000036 chaperone protein DnaJ; Provisional; Region: PRK10767 759914000037 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 759914000038 HSP70 interaction site [polypeptide binding]; other site 759914000039 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 759914000040 substrate binding site [polypeptide binding]; other site 759914000041 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 759914000042 Zn binding sites [ion binding]; other site 759914000043 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 759914000044 dimer interface [polypeptide binding]; other site 759914000045 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 759914000046 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 759914000047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914000048 binding surface 759914000049 TPR motif; other site 759914000050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914000051 binding surface 759914000052 TPR motif; other site 759914000053 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 759914000054 dimer interface [polypeptide binding]; other site 759914000055 pyridoxal binding site [chemical binding]; other site 759914000056 ATP binding site [chemical binding]; other site 759914000057 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 759914000058 MPN+ (JAMM) motif; other site 759914000059 Zinc-binding site [ion binding]; other site 759914000060 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759914000061 non-specific DNA binding site [nucleotide binding]; other site 759914000062 salt bridge; other site 759914000063 sequence-specific DNA binding site [nucleotide binding]; other site 759914000064 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 759914000065 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 759914000066 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 759914000067 EamA-like transporter family; Region: EamA; pfam00892 759914000068 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914000069 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000070 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000071 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000072 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000073 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914000074 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000075 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000076 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000077 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000078 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000079 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914000080 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 759914000081 MgtE intracellular N domain; Region: MgtE_N; pfam03448 759914000082 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 759914000083 Divalent cation transporter; Region: MgtE; pfam01769 759914000084 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 759914000085 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 759914000086 hexamer interface [polypeptide binding]; other site 759914000087 ligand binding site [chemical binding]; other site 759914000088 putative active site [active] 759914000089 NAD(P) binding site [chemical binding]; other site 759914000090 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 759914000091 4Fe-4S binding domain; Region: Fer4; pfam00037 759914000092 4Fe-4S binding domain; Region: Fer4; pfam00037 759914000093 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 759914000094 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 759914000095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759914000096 putative substrate translocation pore; other site 759914000097 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759914000098 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 759914000099 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 759914000100 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 759914000101 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 759914000102 active site 759914000103 catalytic residues [active] 759914000104 metal binding site [ion binding]; metal-binding site 759914000105 homodimer binding site [polypeptide binding]; other site 759914000106 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 759914000107 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 759914000108 carboxyltransferase (CT) interaction site; other site 759914000109 biotinylation site [posttranslational modification]; other site 759914000110 glutamate racemase; Provisional; Region: PRK00865 759914000111 Global regulator protein family; Region: CsrA; cl00670 759914000112 FliW protein; Region: FliW; cl00740 759914000113 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 759914000114 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 759914000115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759914000116 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 759914000117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759914000118 Coenzyme A binding pocket [chemical binding]; other site 759914000119 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 759914000120 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 759914000121 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 759914000122 Amidinotransferase; Region: Amidinotransf; cl12043 759914000123 dihydrodipicolinate reductase; Provisional; Region: PRK00048 759914000124 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 759914000125 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 759914000126 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 759914000127 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 759914000128 dimer interface [polypeptide binding]; other site 759914000129 active site 759914000130 catalytic residue [active] 759914000131 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 759914000132 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 759914000133 metal binding site [ion binding]; metal-binding site 759914000134 dimer interface [polypeptide binding]; other site 759914000135 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 759914000136 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 759914000137 TPP-binding site; other site 759914000138 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 759914000139 PYR/PP interface [polypeptide binding]; other site 759914000140 dimer interface [polypeptide binding]; other site 759914000141 TPP binding site [chemical binding]; other site 759914000142 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 759914000143 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 759914000144 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 759914000145 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 759914000146 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 759914000147 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 759914000148 active site 759914000149 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914000150 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000151 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000152 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000153 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000154 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 759914000155 MgtC family; Region: MgtC; pfam02308 759914000156 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759914000157 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759914000158 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759914000159 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 759914000160 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759914000161 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759914000162 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759914000163 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 759914000164 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759914000165 Peptidase family M23; Region: Peptidase_M23; pfam01551 759914000166 Acylphosphatase; Region: Acylphosphatase; pfam00708 759914000167 potential frameshift: common BLAST hit: gi|225621491|ref|YP_002722750.1| UvrD/REP helicase 759914000168 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 759914000169 Part of AAA domain; Region: AAA_19; pfam13245 759914000170 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 759914000171 Family description; Region: UvrD_C_2; pfam13538 759914000172 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 759914000173 Uncharacterized conserved protein [Function unknown]; Region: COG2128 759914000174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914000175 S-adenosylmethionine binding site [chemical binding]; other site 759914000176 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 759914000177 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 759914000178 META domain; Region: META; pfam03724 759914000179 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 759914000180 propionate/acetate kinase; Provisional; Region: PRK12379 759914000181 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 759914000182 trimer interface [polypeptide binding]; other site 759914000183 active site 759914000184 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 759914000185 fructuronate transporter; Provisional; Region: PRK10034; cl15264 759914000186 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 759914000187 dimerization domain swap beta strand [polypeptide binding]; other site 759914000188 regulatory protein interface [polypeptide binding]; other site 759914000189 active site 759914000190 regulatory phosphorylation site [posttranslational modification]; other site 759914000191 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000192 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000193 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914000194 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914000195 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 759914000196 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 759914000197 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 759914000198 putative catalytic cysteine [active] 759914000199 SirA-like protein; Region: SirA; pfam01206 759914000200 CPxP motif; other site 759914000201 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 759914000202 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cl00540 759914000203 tetramerization interface [polypeptide binding]; other site 759914000204 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 759914000205 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 759914000206 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 759914000207 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 759914000208 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 759914000209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 759914000210 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 759914000211 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 759914000212 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 759914000213 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 759914000214 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 759914000215 putative CoA binding site [chemical binding]; other site 759914000216 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 759914000217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914000218 S-adenosylmethionine binding site [chemical binding]; other site 759914000219 ADP-glucose phosphorylase; Region: PLN02643 759914000220 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 759914000221 nucleotide binding site/active site [active] 759914000222 HIT family signature motif; other site 759914000223 catalytic residue [active] 759914000224 Response regulator receiver domain; Region: Response_reg; pfam00072 759914000225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759914000226 active site 759914000227 phosphorylation site [posttranslational modification] 759914000228 intermolecular recognition site; other site 759914000229 dimerization interface [polypeptide binding]; other site 759914000230 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 759914000231 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 759914000232 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 759914000233 CoenzymeA binding site [chemical binding]; other site 759914000234 subunit interaction site [polypeptide binding]; other site 759914000235 PHB binding site; other site 759914000236 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 759914000237 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 759914000238 active site 759914000239 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 759914000240 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 759914000241 active site 759914000242 dimer interface [polypeptide binding]; other site 759914000243 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 759914000244 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 759914000245 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 759914000246 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 759914000247 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 759914000248 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 759914000249 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759914000250 catalytic residue [active] 759914000251 SirA-like protein; Region: SirA; pfam01206 759914000252 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 759914000253 CPxP motif; other site 759914000254 DsrE/DsrF-like family; Region: DrsE; pfam02635 759914000255 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 759914000256 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 759914000257 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 759914000258 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 759914000259 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 759914000260 active site 759914000261 substrate binding site [chemical binding]; other site 759914000262 metal binding site [ion binding]; metal-binding site 759914000263 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 759914000264 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 759914000265 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 759914000266 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 759914000267 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759914000268 active site 759914000269 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 759914000270 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 759914000271 active site 759914000272 (T/H)XGH motif; other site 759914000273 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 759914000274 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 759914000275 Carbon starvation protein CstA; Region: CstA; pfam02554 759914000276 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 759914000277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914000278 TPR motif; other site 759914000279 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914000280 binding surface 759914000281 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914000282 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 759914000283 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 759914000284 putative active site [active] 759914000285 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 759914000286 dimer interface [polypeptide binding]; other site 759914000287 active site 759914000288 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 759914000289 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 759914000290 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 759914000291 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 759914000292 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 759914000293 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759914000294 RNA binding surface [nucleotide binding]; other site 759914000295 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 759914000296 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 759914000297 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 759914000298 ligand binding site [chemical binding]; other site 759914000299 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 759914000300 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 759914000301 ligand binding site [chemical binding]; other site 759914000302 flexible hinge region; other site 759914000303 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914000304 Ankyrin repeat; Region: Ank; pfam00023 759914000305 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000306 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000307 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 759914000308 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 759914000309 peptide chain release factor 2; Provisional; Region: PRK05589 759914000310 PCRF domain; Region: PCRF; pfam03462 759914000311 RF-1 domain; Region: RF-1; pfam00472 759914000312 galactokinase; Provisional; Region: PRK05322 759914000313 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 759914000314 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 759914000315 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 759914000316 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 759914000317 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 759914000318 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 759914000319 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 759914000320 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 759914000321 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 759914000322 L-fucose isomerase; Provisional; Region: fucI; PRK10991 759914000323 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 759914000324 hexamer (dimer of trimers) interface [polypeptide binding]; other site 759914000325 trimer interface [polypeptide binding]; other site 759914000326 substrate binding site [chemical binding]; other site 759914000327 Mn binding site [ion binding]; other site 759914000328 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759914000329 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 759914000330 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759914000331 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 759914000332 TM-ABC transporter signature motif; other site 759914000333 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 759914000334 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 759914000335 Walker A/P-loop; other site 759914000336 ATP binding site [chemical binding]; other site 759914000337 Q-loop/lid; other site 759914000338 ABC transporter signature motif; other site 759914000339 Walker B; other site 759914000340 D-loop; other site 759914000341 H-loop/switch region; other site 759914000342 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 759914000343 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 759914000344 N- and C-terminal domain interface [polypeptide binding]; other site 759914000345 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 759914000346 active site 759914000347 putative catalytic site [active] 759914000348 metal binding site [ion binding]; metal-binding site 759914000349 ATP binding site [chemical binding]; other site 759914000350 carbohydrate binding site [chemical binding]; other site 759914000351 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 759914000352 intersubunit interface [polypeptide binding]; other site 759914000353 active site 759914000354 Zn2+ binding site [ion binding]; other site 759914000355 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 759914000356 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 759914000357 dimer interface [polypeptide binding]; other site 759914000358 active site 759914000359 metal binding site [ion binding]; metal-binding site 759914000360 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759914000361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759914000362 DNA binding site [nucleotide binding] 759914000363 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759914000364 ligand binding site [chemical binding]; other site 759914000365 dimerization interface [polypeptide binding]; other site 759914000366 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 759914000367 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 759914000368 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 759914000369 N-acetyl-D-glucosamine binding site [chemical binding]; other site 759914000370 catalytic residue [active] 759914000371 OstA-like protein; Region: OstA_2; pfam13100 759914000372 OstA-like protein; Region: OstA; cl00844 759914000373 OstA-like protein; Region: OstA; cl00844 759914000374 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 759914000375 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 759914000376 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 759914000377 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 759914000378 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 759914000379 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 759914000380 diaminopimelate decarboxylase; Region: lysA; TIGR01048 759914000381 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 759914000382 active site 759914000383 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759914000384 substrate binding site [chemical binding]; other site 759914000385 catalytic residues [active] 759914000386 dimer interface [polypeptide binding]; other site 759914000387 Response regulator receiver domain; Region: Response_reg; pfam00072 759914000388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759914000389 active site 759914000390 phosphorylation site [posttranslational modification] 759914000391 intermolecular recognition site; other site 759914000392 dimerization interface [polypeptide binding]; other site 759914000393 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 759914000394 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 759914000395 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 759914000396 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 759914000397 active site 759914000398 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 759914000399 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cd00528 759914000400 trimer interface [polypeptide binding]; other site 759914000401 dimer interface [polypeptide binding]; other site 759914000402 putative active site [active] 759914000403 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 759914000404 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914000405 FeS/SAM binding site; other site 759914000406 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 759914000407 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 759914000408 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 759914000409 dimer interface [polypeptide binding]; other site 759914000410 putative functional site; other site 759914000411 putative MPT binding site; other site 759914000412 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 759914000413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914000414 Walker A/P-loop; other site 759914000415 ATP binding site [chemical binding]; other site 759914000416 Q-loop/lid; other site 759914000417 ABC transporter signature motif; other site 759914000418 Walker B; other site 759914000419 D-loop; other site 759914000420 H-loop/switch region; other site 759914000421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914000422 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 759914000423 dimer interface [polypeptide binding]; other site 759914000424 conserved gate region; other site 759914000425 putative PBP binding loops; other site 759914000426 ABC-ATPase subunit interface; other site 759914000427 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 759914000428 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 759914000429 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 759914000430 MPT binding site; other site 759914000431 trimer interface [polypeptide binding]; other site 759914000432 MOSC domain; Region: MOSC; pfam03473 759914000433 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 759914000434 hydrophobic ligand binding site; other site 759914000435 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000436 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000437 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000438 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000439 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000440 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000441 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856 759914000442 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 759914000443 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 759914000444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759914000445 ATP binding site [chemical binding]; other site 759914000446 putative Mg++ binding site [ion binding]; other site 759914000447 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 759914000448 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 759914000449 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 759914000450 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 759914000451 HsdM N-terminal domain; Region: HsdM_N; pfam12161 759914000452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914000453 S-adenosylmethionine binding site [chemical binding]; other site 759914000454 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 759914000455 active site residue [active] 759914000456 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 759914000457 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 759914000458 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 759914000459 catalytic residues [active] 759914000460 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914000461 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000462 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 759914000463 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 759914000464 active site 2 [active] 759914000465 active site 1 [active] 759914000466 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 759914000467 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 759914000468 tartrate dehydrogenase; Region: TTC; TIGR02089 759914000469 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 759914000470 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 759914000471 substrate binding site [chemical binding]; other site 759914000472 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 759914000473 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 759914000474 substrate binding site [chemical binding]; other site 759914000475 ligand binding site [chemical binding]; other site 759914000476 2-isopropylmalate synthase; Validated; Region: PRK00915 759914000477 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 759914000478 active site 759914000479 catalytic residues [active] 759914000480 metal binding site [ion binding]; metal-binding site 759914000481 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 759914000482 ketol-acid reductoisomerase; Provisional; Region: PRK05479 759914000483 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 759914000484 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 759914000485 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 759914000486 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 759914000487 putative valine binding site [chemical binding]; other site 759914000488 dimer interface [polypeptide binding]; other site 759914000489 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 759914000490 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 759914000491 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 759914000492 PYR/PP interface [polypeptide binding]; other site 759914000493 dimer interface [polypeptide binding]; other site 759914000494 TPP binding site [chemical binding]; other site 759914000495 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 759914000496 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 759914000497 TPP-binding site [chemical binding]; other site 759914000498 dimer interface [polypeptide binding]; other site 759914000499 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 759914000500 ABC1 family; Region: ABC1; cl17513 759914000501 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914000502 Oxygen tolerance; Region: BatD; pfam13584 759914000503 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914000504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914000505 TPR motif; other site 759914000506 binding surface 759914000507 von Willebrand factor type A domain; Region: VWA_2; pfam13519 759914000508 metal ion-dependent adhesion site (MIDAS); other site 759914000509 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 759914000510 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 759914000511 active site 759914000512 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759914000513 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 759914000514 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759914000515 ABC transporter; Region: ABC_tran_2; pfam12848 759914000516 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759914000517 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 759914000518 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759914000519 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 759914000520 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 759914000521 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 759914000522 catalytic triad [active] 759914000523 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914000524 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759914000525 peptide binding site [polypeptide binding]; other site 759914000526 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 759914000527 TPR repeat; Region: TPR_11; pfam13414 759914000528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914000529 binding surface 759914000530 TPR motif; other site 759914000531 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914000532 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914000533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914000534 binding surface 759914000535 TPR motif; other site 759914000536 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 759914000537 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 759914000538 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759914000539 ATP binding site [chemical binding]; other site 759914000540 putative Mg++ binding site [ion binding]; other site 759914000541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759914000542 nucleotide binding region [chemical binding]; other site 759914000543 ATP-binding site [chemical binding]; other site 759914000544 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 759914000545 Leucine rich repeat; Region: LRR_8; pfam13855 759914000546 Leucine rich repeat; Region: LRR_8; pfam13855 759914000547 Protein of unknown function (DUF554); Region: DUF554; pfam04474 759914000548 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 759914000549 putative homodimer interface [polypeptide binding]; other site 759914000550 putative active site pocket [active] 759914000551 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 759914000552 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 759914000553 putative active site [active] 759914000554 catalytic site [active] 759914000555 Cache domain; Region: Cache_1; pfam02743 759914000556 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914000557 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914000558 dimer interface [polypeptide binding]; other site 759914000559 putative CheW interface [polypeptide binding]; other site 759914000560 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000561 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000562 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914000563 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000564 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000565 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000566 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000567 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000568 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000569 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000570 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000571 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 759914000572 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 759914000573 flagellin; Provisional; Region: PRK12804 759914000574 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 759914000575 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 759914000576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 759914000577 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 759914000578 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 759914000579 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 759914000580 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 759914000581 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 759914000582 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 759914000583 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 759914000584 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 759914000585 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 759914000586 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 759914000587 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 759914000588 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 759914000589 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914000590 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000591 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000592 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000593 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000594 ScpA/B protein; Region: ScpA_ScpB; cl00598 759914000595 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759914000596 EamA-like transporter family; Region: EamA; pfam00892 759914000597 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 759914000598 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 759914000599 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 759914000600 nucleotide binding region [chemical binding]; other site 759914000601 SEC-C motif; Region: SEC-C; pfam02810 759914000602 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 759914000603 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 759914000604 Septum formation initiator; Region: DivIC; cl17659 759914000605 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759914000606 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759914000607 Walker A/P-loop; other site 759914000608 ATP binding site [chemical binding]; other site 759914000609 Q-loop/lid; other site 759914000610 ABC transporter signature motif; other site 759914000611 Walker B; other site 759914000612 D-loop; other site 759914000613 H-loop/switch region; other site 759914000614 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 759914000615 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759914000616 potential frameshift: common BLAST hit: gi|296125850|ref|YP_003633102.1| Na+/Ca+ antiporter, CaCA family 759914000617 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 759914000618 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 759914000619 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 759914000620 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 759914000621 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 759914000622 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 759914000623 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 759914000624 glutaminase active site [active] 759914000625 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 759914000626 dimer interface [polypeptide binding]; other site 759914000627 active site 759914000628 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 759914000629 dimer interface [polypeptide binding]; other site 759914000630 active site 759914000631 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 759914000632 rRNA interaction site [nucleotide binding]; other site 759914000633 S8 interaction site; other site 759914000634 putative laminin-1 binding site; other site 759914000635 elongation factor Ts; Provisional; Region: tsf; PRK09377 759914000636 UBA/TS-N domain; Region: UBA; pfam00627 759914000637 Elongation factor TS; Region: EF_TS; pfam00889 759914000638 Elongation factor TS; Region: EF_TS; pfam00889 759914000639 serine O-acetyltransferase; Region: cysE; TIGR01172 759914000640 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 759914000641 trimer interface [polypeptide binding]; other site 759914000642 active site 759914000643 substrate binding site [chemical binding]; other site 759914000644 CoA binding site [chemical binding]; other site 759914000645 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 759914000646 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 759914000647 dimer interface [polypeptide binding]; other site 759914000648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914000649 catalytic residue [active] 759914000650 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 759914000651 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 759914000652 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759914000653 catalytic residue [active] 759914000654 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 759914000655 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 759914000656 trimerization site [polypeptide binding]; other site 759914000657 active site 759914000658 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 759914000659 NifU-like domain; Region: NifU; pfam01106 759914000660 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 759914000661 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 759914000662 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 759914000663 active site 759914000664 catalytic site [active] 759914000665 homodimer interface [polypeptide binding]; other site 759914000666 Lid 1; other site 759914000667 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 759914000668 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 759914000669 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 759914000670 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759914000671 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759914000672 ligand binding site [chemical binding]; other site 759914000673 dimerization interface [polypeptide binding]; other site 759914000674 alpha-galactosidase; Provisional; Region: PRK15076 759914000675 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 759914000676 NAD(P) binding site [chemical binding]; other site 759914000677 LDH/MDH dimer interface [polypeptide binding]; other site 759914000678 substrate binding site [chemical binding]; other site 759914000679 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 759914000680 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 759914000681 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 759914000682 active site turn [active] 759914000683 phosphorylation site [posttranslational modification] 759914000684 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 759914000685 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 759914000686 NAD binding site [chemical binding]; other site 759914000687 sugar binding site [chemical binding]; other site 759914000688 divalent metal binding site [ion binding]; other site 759914000689 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 759914000690 dimer interface [polypeptide binding]; other site 759914000691 homoserine kinase; Provisional; Region: PRK01212 759914000692 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 759914000693 threonine synthase; Reviewed; Region: PRK06721 759914000694 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 759914000695 homodimer interface [polypeptide binding]; other site 759914000696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914000697 catalytic residue [active] 759914000698 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 759914000699 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 759914000700 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 759914000701 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 759914000702 catalytic site [active] 759914000703 subunit interface [polypeptide binding]; other site 759914000704 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 759914000705 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 759914000706 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 759914000707 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 759914000708 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 759914000709 ATP-grasp domain; Region: ATP-grasp_4; cl17255 759914000710 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 759914000711 IMP binding site; other site 759914000712 dimer interface [polypeptide binding]; other site 759914000713 interdomain contacts; other site 759914000714 partial ornithine binding site; other site 759914000715 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 759914000716 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 759914000717 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 759914000718 aspartate aminotransferase; Provisional; Region: PRK07568 759914000719 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759914000720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914000721 homodimer interface [polypeptide binding]; other site 759914000722 catalytic residue [active] 759914000723 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 759914000724 active site residue [active] 759914000725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 759914000726 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 759914000727 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 759914000728 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 759914000729 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 759914000730 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 759914000731 PhoU domain; Region: PhoU; pfam01895 759914000732 PhoU domain; Region: PhoU; pfam01895 759914000733 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 759914000734 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 759914000735 Walker A/P-loop; other site 759914000736 ATP binding site [chemical binding]; other site 759914000737 Q-loop/lid; other site 759914000738 ABC transporter signature motif; other site 759914000739 Walker B; other site 759914000740 D-loop; other site 759914000741 H-loop/switch region; other site 759914000742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914000743 dimer interface [polypeptide binding]; other site 759914000744 conserved gate region; other site 759914000745 putative PBP binding loops; other site 759914000746 ABC-ATPase subunit interface; other site 759914000747 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 759914000748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914000749 dimer interface [polypeptide binding]; other site 759914000750 conserved gate region; other site 759914000751 putative PBP binding loops; other site 759914000752 ABC-ATPase subunit interface; other site 759914000753 PBP superfamily domain; Region: PBP_like_2; cl17296 759914000754 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 759914000755 Melibiase; Region: Melibiase; pfam02065 759914000756 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 759914000757 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 759914000758 tetramer interface [polypeptide binding]; other site 759914000759 heme binding pocket [chemical binding]; other site 759914000760 NADPH binding site [chemical binding]; other site 759914000761 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 759914000762 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 759914000763 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 759914000764 Putative N-acetylmannosamine-6-phosphate epimerase; Region: NanE; pfam04131 759914000765 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 759914000766 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 759914000767 Predicted permeases [General function prediction only]; Region: COG0701 759914000768 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 759914000769 arsenical-resistance protein; Region: acr3; TIGR00832 759914000770 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759914000771 dimerization interface [polypeptide binding]; other site 759914000772 putative DNA binding site [nucleotide binding]; other site 759914000773 putative Zn2+ binding site [ion binding]; other site 759914000774 Flavodoxin domain; Region: Flavodoxin_3; pfam12641 759914000775 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 759914000776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914000777 S-adenosylmethionine binding site [chemical binding]; other site 759914000778 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 759914000779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914000780 binding surface 759914000781 TPR motif; other site 759914000782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914000783 binding surface 759914000784 TPR motif; other site 759914000785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914000786 binding surface 759914000787 TPR motif; other site 759914000788 Predicted transcriptional regulators [Transcription]; Region: COG1695 759914000789 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 759914000790 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 759914000791 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 759914000792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759914000793 putative substrate translocation pore; other site 759914000794 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 759914000795 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 759914000796 active site 759914000797 FMN binding site [chemical binding]; other site 759914000798 substrate binding site [chemical binding]; other site 759914000799 putative catalytic residue [active] 759914000800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759914000801 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759914000802 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 759914000803 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 759914000804 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 759914000805 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 759914000806 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 759914000807 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 759914000808 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 759914000809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914000810 Walker A/P-loop; other site 759914000811 ATP binding site [chemical binding]; other site 759914000812 Q-loop/lid; other site 759914000813 ABC transporter signature motif; other site 759914000814 Walker B; other site 759914000815 D-loop; other site 759914000816 H-loop/switch region; other site 759914000817 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 759914000818 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 759914000819 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 759914000820 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 759914000821 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 759914000822 heterotetramer interface [polypeptide binding]; other site 759914000823 active site pocket [active] 759914000824 cleavage site 759914000825 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 759914000826 feedback inhibition sensing region; other site 759914000827 homohexameric interface [polypeptide binding]; other site 759914000828 nucleotide binding site [chemical binding]; other site 759914000829 N-acetyl-L-glutamate binding site [chemical binding]; other site 759914000830 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 759914000831 acetylornithine aminotransferase; Provisional; Region: PRK02627 759914000832 inhibitor-cofactor binding pocket; inhibition site 759914000833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914000834 catalytic residue [active] 759914000835 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 759914000836 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 759914000837 Walker A/P-loop; other site 759914000838 ATP binding site [chemical binding]; other site 759914000839 Q-loop/lid; other site 759914000840 ABC transporter signature motif; other site 759914000841 Walker B; other site 759914000842 D-loop; other site 759914000843 H-loop/switch region; other site 759914000844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759914000845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759914000846 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 759914000847 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 759914000848 active site 759914000849 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 759914000850 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 759914000851 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 759914000852 oligomer interface [polypeptide binding]; other site 759914000853 active site 759914000854 metal binding site [ion binding]; metal-binding site 759914000855 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 759914000856 BNR repeat-like domain; Region: BNR_2; pfam13088 759914000857 Putative motility protein; Region: YjfB_motility; pfam14070 759914000858 Predicted GTPase [General function prediction only]; Region: Obg; COG0536 759914000859 GTP1/OBG; Region: GTP1_OBG; pfam01018 759914000860 Obg GTPase; Region: Obg; cd01898 759914000861 G1 box; other site 759914000862 GTP/Mg2+ binding site [chemical binding]; other site 759914000863 Switch I region; other site 759914000864 G2 box; other site 759914000865 G3 box; other site 759914000866 Switch II region; other site 759914000867 G4 box; other site 759914000868 G5 box; other site 759914000869 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 759914000870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914000871 FeS/SAM binding site; other site 759914000872 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 759914000873 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 759914000874 dimerization interface [polypeptide binding]; other site 759914000875 active site 759914000876 metal binding site [ion binding]; metal-binding site 759914000877 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 759914000878 dsRNA binding site [nucleotide binding]; other site 759914000879 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 759914000880 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 759914000881 substrate binding site [chemical binding]; other site 759914000882 hexamer interface [polypeptide binding]; other site 759914000883 metal binding site [ion binding]; metal-binding site 759914000884 Response regulator receiver domain; Region: Response_reg; pfam00072 759914000885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759914000886 active site 759914000887 phosphorylation site [posttranslational modification] 759914000888 intermolecular recognition site; other site 759914000889 dimerization interface [polypeptide binding]; other site 759914000890 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 759914000891 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 759914000892 active site 759914000893 HIGH motif; other site 759914000894 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 759914000895 active site 759914000896 KMSKS motif; other site 759914000897 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 759914000898 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 759914000899 catalytic triad [active] 759914000900 conserved cis-peptide bond; other site 759914000901 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 759914000902 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 759914000903 DNA binding site [nucleotide binding] 759914000904 active site 759914000905 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 759914000906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759914000907 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 759914000908 Na binding site [ion binding]; other site 759914000909 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 759914000910 anti sigma factor interaction site; other site 759914000911 regulatory phosphorylation site [posttranslational modification]; other site 759914000912 selenocysteine synthase; Provisional; Region: PRK04311 759914000913 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 759914000914 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 759914000915 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 759914000916 G1 box; other site 759914000917 putative GEF interaction site [polypeptide binding]; other site 759914000918 GTP/Mg2+ binding site [chemical binding]; other site 759914000919 Switch I region; other site 759914000920 G2 box; other site 759914000921 G3 box; other site 759914000922 Switch II region; other site 759914000923 G4 box; other site 759914000924 G5 box; other site 759914000925 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 759914000926 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 759914000927 recombination protein RecR; Reviewed; Region: recR; PRK00076 759914000928 RecR protein; Region: RecR; pfam02132 759914000929 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 759914000930 putative active site [active] 759914000931 putative metal-binding site [ion binding]; other site 759914000932 tetramer interface [polypeptide binding]; other site 759914000933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 759914000934 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 759914000935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914000936 active site 759914000937 motif I; other site 759914000938 motif II; other site 759914000939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914000940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914000941 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 759914000942 active site 759914000943 motif I; other site 759914000944 motif II; other site 759914000945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914000946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914000947 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 759914000948 active site 759914000949 motif I; other site 759914000950 motif II; other site 759914000951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914000952 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 759914000953 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 759914000954 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 759914000955 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 759914000956 putative binding surface; other site 759914000957 active site 759914000958 P2 response regulator binding domain; Region: P2; pfam07194 759914000959 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 759914000960 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 759914000961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759914000962 ATP binding site [chemical binding]; other site 759914000963 Mg2+ binding site [ion binding]; other site 759914000964 G-X-G motif; other site 759914000965 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 759914000966 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 759914000967 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 759914000968 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 759914000969 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 759914000970 active site 759914000971 metal binding site [ion binding]; metal-binding site 759914000972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759914000973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759914000974 putative substrate translocation pore; other site 759914000975 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 759914000976 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 759914000977 FMN binding site [chemical binding]; other site 759914000978 active site 759914000979 catalytic residues [active] 759914000980 substrate binding site [chemical binding]; other site 759914000981 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 759914000982 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 759914000983 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 759914000984 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 759914000985 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 759914000986 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 759914000987 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 759914000988 Walker A/P-loop; other site 759914000989 ATP binding site [chemical binding]; other site 759914000990 Q-loop/lid; other site 759914000991 ABC transporter signature motif; other site 759914000992 Walker B; other site 759914000993 D-loop; other site 759914000994 H-loop/switch region; other site 759914000995 META domain; Region: META; pfam03724 759914000996 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914000997 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914000998 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914000999 GTPase RsgA; Reviewed; Region: PRK01889 759914001000 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 759914001001 RNA binding site [nucleotide binding]; other site 759914001002 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 759914001003 GTPase/Zn-binding domain interface [polypeptide binding]; other site 759914001004 GTP/Mg2+ binding site [chemical binding]; other site 759914001005 G4 box; other site 759914001006 G5 box; other site 759914001007 G1 box; other site 759914001008 Switch I region; other site 759914001009 G2 box; other site 759914001010 G3 box; other site 759914001011 Switch II region; other site 759914001012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759914001013 putative substrate translocation pore; other site 759914001014 GAF domain; Region: GAF_3; pfam13492 759914001015 GAF domain; Region: GAF_2; pfam13185 759914001016 GAF domain; Region: GAF; pfam01590 759914001017 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 759914001018 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 759914001019 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 759914001020 Transglycosylase; Region: Transgly; pfam00912 759914001021 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 759914001022 TraB family; Region: TraB; cl12050 759914001023 YcfA-like protein; Region: YcfA; cl00752 759914001024 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 759914001025 HNH endonuclease; Region: HNH_5; pfam14279 759914001026 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 759914001027 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 759914001028 putative dimer interface [polypeptide binding]; other site 759914001029 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 759914001030 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 759914001031 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 759914001032 homodimer interface [polypeptide binding]; other site 759914001033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914001034 catalytic residue [active] 759914001035 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 759914001036 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 759914001037 ligand binding site [chemical binding]; other site 759914001038 NAD binding site [chemical binding]; other site 759914001039 dimerization interface [polypeptide binding]; other site 759914001040 catalytic site [active] 759914001041 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 759914001042 phosphoserine phosphatase SerB; Region: serB; TIGR00338 759914001043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914001044 motif II; other site 759914001045 citrate synthase; Provisional; Region: PRK14032 759914001046 Citrate synthase; Region: Citrate_synt; pfam00285 759914001047 oxalacetate binding site [chemical binding]; other site 759914001048 citrylCoA binding site [chemical binding]; other site 759914001049 coenzyme A binding site [chemical binding]; other site 759914001050 catalytic triad [active] 759914001051 isocitrate dehydrogenase; Validated; Region: PRK07362 759914001052 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 759914001053 aconitate hydratase; Validated; Region: PRK07229 759914001054 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 759914001055 substrate binding site [chemical binding]; other site 759914001056 ligand binding site [chemical binding]; other site 759914001057 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 759914001058 substrate binding site [chemical binding]; other site 759914001059 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 759914001060 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 759914001061 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 759914001062 active site 759914001063 catalytic site [active] 759914001064 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 759914001065 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 759914001066 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914001067 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 759914001068 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 759914001069 FAD binding site [chemical binding]; other site 759914001070 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 759914001071 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 759914001072 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 759914001073 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 759914001074 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 759914001075 substrate binding pocket [chemical binding]; other site 759914001076 dimer interface [polypeptide binding]; other site 759914001077 inhibitor binding site; inhibition site 759914001078 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 759914001079 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 759914001080 B12 binding site [chemical binding]; other site 759914001081 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 759914001082 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759914001083 active site 759914001084 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 759914001085 putative trimer interface [polypeptide binding]; other site 759914001086 putative CoA binding site [chemical binding]; other site 759914001087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 759914001088 Predicted permeases [General function prediction only]; Region: COG0795 759914001089 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 759914001090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759914001091 Coenzyme A binding pocket [chemical binding]; other site 759914001092 prolyl-tRNA synthetase; Provisional; Region: PRK09194 759914001093 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 759914001094 dimer interface [polypeptide binding]; other site 759914001095 motif 1; other site 759914001096 active site 759914001097 motif 2; other site 759914001098 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 759914001099 putative deacylase active site [active] 759914001100 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 759914001101 active site 759914001102 motif 3; other site 759914001103 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 759914001104 anticodon binding site; other site 759914001105 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 759914001106 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 759914001107 HflX GTPase family; Region: HflX; cd01878 759914001108 G1 box; other site 759914001109 GTP/Mg2+ binding site [chemical binding]; other site 759914001110 Switch I region; other site 759914001111 G2 box; other site 759914001112 G3 box; other site 759914001113 Switch II region; other site 759914001114 G4 box; other site 759914001115 G5 box; other site 759914001116 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759914001117 Zn2+ binding site [ion binding]; other site 759914001118 Mg2+ binding site [ion binding]; other site 759914001119 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 759914001120 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 759914001121 putative active site [active] 759914001122 metal binding site [ion binding]; metal-binding site 759914001123 homodimer binding site [polypeptide binding]; other site 759914001124 phosphodiesterase; Provisional; Region: PRK12704 759914001125 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759914001126 Zn2+ binding site [ion binding]; other site 759914001127 Mg2+ binding site [ion binding]; other site 759914001128 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 759914001129 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 759914001130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759914001131 Coenzyme A binding pocket [chemical binding]; other site 759914001132 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 759914001133 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 759914001134 ring oligomerisation interface [polypeptide binding]; other site 759914001135 ATP/Mg binding site [chemical binding]; other site 759914001136 stacking interactions; other site 759914001137 hinge regions; other site 759914001138 potassium/proton antiporter; Reviewed; Region: PRK05326 759914001139 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 759914001140 TrkA-C domain; Region: TrkA_C; pfam02080 759914001141 TrkA-C domain; Region: TrkA_C; pfam02080 759914001142 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 759914001143 methionine sulfoxide reductase B; Provisional; Region: PRK05508 759914001144 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 759914001145 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 759914001146 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 759914001147 Serine hydrolase (FSH1); Region: FSH1; pfam03959 759914001148 cytosolic glyceraldehyde 3-phosphate dehydrogenase; Provisional; Region: PTZ00434 759914001149 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 759914001150 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 759914001151 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 759914001152 Phosphoglycerate kinase; Region: PGK; pfam00162 759914001153 substrate binding site [chemical binding]; other site 759914001154 hinge regions; other site 759914001155 ADP binding site [chemical binding]; other site 759914001156 catalytic site [active] 759914001157 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 759914001158 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 759914001159 active site 759914001160 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 759914001161 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 759914001162 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 759914001163 active site turn [active] 759914001164 phosphorylation site [posttranslational modification] 759914001165 putative hydrolase; Provisional; Region: PRK02113 759914001166 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 759914001167 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 759914001168 TRAM domain; Region: TRAM; cl01282 759914001169 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 759914001170 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 759914001171 YcfA-like protein; Region: YcfA; cl00752 759914001172 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914001173 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 759914001174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914001175 motif II; other site 759914001176 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 759914001177 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 759914001178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 759914001179 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 759914001180 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 759914001181 substrate binding pocket [chemical binding]; other site 759914001182 chain length determination region; other site 759914001183 substrate-Mg2+ binding site; other site 759914001184 catalytic residues [active] 759914001185 aspartate-rich region 1; other site 759914001186 active site lid residues [active] 759914001187 aspartate-rich region 2; other site 759914001188 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 759914001189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759914001190 Bax inhibitor 1 like; Region: BaxI_1; cl17691 759914001191 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914001192 TPR motif; other site 759914001193 binding surface 759914001194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001195 binding surface 759914001196 TPR motif; other site 759914001197 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 759914001198 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 759914001199 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 759914001200 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 759914001201 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 759914001202 NAD binding site [chemical binding]; other site 759914001203 homodimer interface [polypeptide binding]; other site 759914001204 active site 759914001205 substrate binding site [chemical binding]; other site 759914001206 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914001207 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914001208 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914001209 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914001210 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914001211 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 759914001212 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 759914001213 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 759914001214 dimerization domain swap beta strand [polypeptide binding]; other site 759914001215 regulatory protein interface [polypeptide binding]; other site 759914001216 active site 759914001217 regulatory phosphorylation site [posttranslational modification]; other site 759914001218 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 759914001219 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 759914001220 HEAT repeats; Region: HEAT_2; pfam13646 759914001221 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 759914001222 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 759914001223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 759914001224 YheO-like PAS domain; Region: PAS_6; pfam08348 759914001225 HTH domain; Region: HTH_22; pfam13309 759914001226 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 759914001227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759914001228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914001229 homodimer interface [polypeptide binding]; other site 759914001230 catalytic residue [active] 759914001231 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 759914001232 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 759914001233 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 759914001234 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 759914001235 active site 759914001236 catalytic site [active] 759914001237 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 759914001238 putative oxidoreductase; Provisional; Region: PRK12831 759914001239 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759914001240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759914001241 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759914001242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759914001243 active site 759914001244 phosphorylation site [posttranslational modification] 759914001245 intermolecular recognition site; other site 759914001246 dimerization interface [polypeptide binding]; other site 759914001247 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759914001248 DNA binding site [nucleotide binding] 759914001249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759914001250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759914001251 dimer interface [polypeptide binding]; other site 759914001252 phosphorylation site [posttranslational modification] 759914001253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759914001254 ATP binding site [chemical binding]; other site 759914001255 Mg2+ binding site [ion binding]; other site 759914001256 G-X-G motif; other site 759914001257 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 759914001258 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 759914001259 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 759914001260 active site 759914001261 Int/Topo IB signature motif; other site 759914001262 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 759914001263 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 759914001264 L-serine binding site [chemical binding]; other site 759914001265 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 759914001266 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 759914001267 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 759914001268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759914001269 Coenzyme A binding pocket [chemical binding]; other site 759914001270 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759914001271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 759914001272 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759914001273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914001274 Walker A/P-loop; other site 759914001275 ATP binding site [chemical binding]; other site 759914001276 Q-loop/lid; other site 759914001277 ABC transporter signature motif; other site 759914001278 Walker B; other site 759914001279 D-loop; other site 759914001280 H-loop/switch region; other site 759914001281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001282 TPR motif; other site 759914001283 TPR repeat; Region: TPR_11; pfam13414 759914001284 binding surface 759914001285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001286 binding surface 759914001287 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914001288 TPR motif; other site 759914001289 UGMP family protein; Validated; Region: PRK09604 759914001290 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 759914001291 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 759914001292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759914001293 active site 759914001294 phosphorylation site [posttranslational modification] 759914001295 intermolecular recognition site; other site 759914001296 dimerization interface [polypeptide binding]; other site 759914001297 CheB methylesterase; Region: CheB_methylest; pfam01339 759914001298 CheD chemotactic sensory transduction; Region: CheD; cl00810 759914001299 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 759914001300 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 759914001301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914001302 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 759914001303 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 759914001304 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 759914001305 putative binding surface; other site 759914001306 active site 759914001307 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 759914001308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759914001309 ATP binding site [chemical binding]; other site 759914001310 Mg2+ binding site [ion binding]; other site 759914001311 G-X-G motif; other site 759914001312 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 759914001313 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 759914001314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759914001315 active site 759914001316 phosphorylation site [posttranslational modification] 759914001317 intermolecular recognition site; other site 759914001318 dimerization interface [polypeptide binding]; other site 759914001319 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 759914001320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 759914001321 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 759914001322 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 759914001323 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 759914001324 amidase catalytic site [active] 759914001325 Zn binding residues [ion binding]; other site 759914001326 substrate binding site [chemical binding]; other site 759914001327 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 759914001328 Domain of unknown function DUF21; Region: DUF21; pfam01595 759914001329 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 759914001330 Transporter associated domain; Region: CorC_HlyC; smart01091 759914001331 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 759914001332 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 759914001333 putative active site [active] 759914001334 putative metal binding site [ion binding]; other site 759914001335 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 759914001336 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 759914001337 putative active site [active] 759914001338 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 759914001339 Domain of unknown function DUF20; Region: UPF0118; pfam01594 759914001340 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 759914001341 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 759914001342 homodimer interface [polypeptide binding]; other site 759914001343 metal binding site [ion binding]; metal-binding site 759914001344 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 759914001345 homodimer interface [polypeptide binding]; other site 759914001346 active site 759914001347 putative chemical substrate binding site [chemical binding]; other site 759914001348 metal binding site [ion binding]; metal-binding site 759914001349 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 759914001350 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 759914001351 active site 759914001352 intersubunit interface [polypeptide binding]; other site 759914001353 catalytic residue [active] 759914001354 Glucuronate isomerase; Region: UxaC; pfam02614 759914001355 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 759914001356 mannonate dehydratase; Provisional; Region: PRK03906 759914001357 mannonate dehydratase; Region: uxuA; TIGR00695 759914001358 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 759914001359 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 759914001360 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 759914001361 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759914001362 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914001363 peptide binding site [polypeptide binding]; other site 759914001364 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 759914001365 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 759914001366 putative NAD(P) binding site [chemical binding]; other site 759914001367 putative substrate binding site [chemical binding]; other site 759914001368 catalytic Zn binding site [ion binding]; other site 759914001369 structural Zn binding site [ion binding]; other site 759914001370 dimer interface [polypeptide binding]; other site 759914001371 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759914001372 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914001373 peptide binding site [polypeptide binding]; other site 759914001374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001375 TPR motif; other site 759914001376 binding surface 759914001377 TPR repeat; Region: TPR_11; pfam13414 759914001378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001379 binding surface 759914001380 TPR repeat; Region: TPR_11; pfam13414 759914001381 TPR motif; other site 759914001382 TPR repeat; Region: TPR_11; pfam13414 759914001383 TPR repeat; Region: TPR_11; pfam13414 759914001384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001385 binding surface 759914001386 TPR motif; other site 759914001387 TPR repeat; Region: TPR_11; pfam13414 759914001388 TPR repeat; Region: TPR_11; pfam13414 759914001389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001390 binding surface 759914001391 TPR motif; other site 759914001392 TPR repeat; Region: TPR_11; pfam13414 759914001393 TPR repeat; Region: TPR_11; pfam13414 759914001394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001395 binding surface 759914001396 TPR motif; other site 759914001397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001398 binding surface 759914001399 TPR motif; other site 759914001400 TPR repeat; Region: TPR_11; pfam13414 759914001401 TPR repeat; Region: TPR_11; pfam13414 759914001402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001403 binding surface 759914001404 TPR motif; other site 759914001405 TPR repeat; Region: TPR_11; pfam13414 759914001406 TPR repeat; Region: TPR_11; pfam13414 759914001407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001408 binding surface 759914001409 TPR motif; other site 759914001410 TPR repeat; Region: TPR_11; pfam13414 759914001411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001412 binding surface 759914001413 TPR motif; other site 759914001414 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914001415 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914001416 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914001417 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914001418 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914001419 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914001420 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914001421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759914001422 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 759914001423 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 759914001424 HIGH motif; other site 759914001425 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 759914001426 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759914001427 active site 759914001428 KMSKS motif; other site 759914001429 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 759914001430 tRNA binding surface [nucleotide binding]; other site 759914001431 AAA domain; Region: AAA_21; pfam13304 759914001432 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 759914001433 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 759914001434 putative NAD(P) binding site [chemical binding]; other site 759914001435 catalytic Zn binding site [ion binding]; other site 759914001436 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 759914001437 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 759914001438 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 759914001439 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 759914001440 Walker A/P-loop; other site 759914001441 ATP binding site [chemical binding]; other site 759914001442 Q-loop/lid; other site 759914001443 ABC transporter signature motif; other site 759914001444 Walker B; other site 759914001445 D-loop; other site 759914001446 H-loop/switch region; other site 759914001447 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 759914001448 mce related protein; Region: MCE; pfam02470 759914001449 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 759914001450 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 759914001451 active site 759914001452 dimerization interface [polypeptide binding]; other site 759914001453 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 759914001454 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 759914001455 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 759914001456 alpha subunit interaction interface [polypeptide binding]; other site 759914001457 Walker A motif; other site 759914001458 ATP binding site [chemical binding]; other site 759914001459 Walker B motif; other site 759914001460 inhibitor binding site; inhibition site 759914001461 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 759914001462 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 759914001463 dimerization interface [polypeptide binding]; other site 759914001464 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914001465 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914001466 dimer interface [polypeptide binding]; other site 759914001467 putative CheW interface [polypeptide binding]; other site 759914001468 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 759914001469 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 759914001470 ligand binding site [chemical binding]; other site 759914001471 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 759914001472 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 759914001473 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759914001474 Flavodoxin domain; Region: Flavodoxin_5; cl17428 759914001475 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 759914001476 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 759914001477 Sodium Bile acid symporter family; Region: SBF; pfam01758 759914001478 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 759914001479 dimer interface [polypeptide binding]; other site 759914001480 putative radical transfer pathway; other site 759914001481 diiron center [ion binding]; other site 759914001482 tyrosyl radical; other site 759914001483 ribonucleoside-diphosphate reductase subunit alpha; Provisional; Region: nrdA; PHA02572 759914001484 ATP cone domain; Region: ATP-cone; pfam03477 759914001485 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 759914001486 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 759914001487 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 759914001488 23S rRNA binding site [nucleotide binding]; other site 759914001489 L21 binding site [polypeptide binding]; other site 759914001490 L13 binding site [polypeptide binding]; other site 759914001491 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 759914001492 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 759914001493 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 759914001494 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 759914001495 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 759914001496 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 759914001497 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 759914001498 active site 759914001499 dimer interface [polypeptide binding]; other site 759914001500 motif 1; other site 759914001501 motif 2; other site 759914001502 motif 3; other site 759914001503 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 759914001504 anticodon binding site; other site 759914001505 TM2 domain; Region: TM2; pfam05154 759914001506 oligoendopeptidase F; Region: pepF; TIGR00181 759914001507 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 759914001508 active site 759914001509 Zn binding site [ion binding]; other site 759914001510 glycogen synthase; Provisional; Region: glgA; PRK00654 759914001511 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 759914001512 ADP-binding pocket [chemical binding]; other site 759914001513 homodimer interface [polypeptide binding]; other site 759914001514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 759914001515 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 759914001516 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 759914001517 catalytic residues [active] 759914001518 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 759914001519 N-acetyl-D-glucosamine binding site [chemical binding]; other site 759914001520 catalytic residue [active] 759914001521 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759914001522 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759914001523 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 759914001524 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 759914001525 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 759914001526 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 759914001527 catalytic residue [active] 759914001528 putative FPP diphosphate binding site; other site 759914001529 putative FPP binding hydrophobic cleft; other site 759914001530 dimer interface [polypeptide binding]; other site 759914001531 putative IPP diphosphate binding site; other site 759914001532 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 759914001533 ribosome recycling factor; Reviewed; Region: frr; PRK00083 759914001534 hinge region; other site 759914001535 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 759914001536 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 759914001537 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 759914001538 active site 759914001539 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 759914001540 active site 759914001541 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 759914001542 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 759914001543 dimer interface [polypeptide binding]; other site 759914001544 active site 759914001545 acyl carrier protein; Provisional; Region: acpP; PRK00982 759914001546 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 759914001547 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 759914001548 NAD(P) binding site [chemical binding]; other site 759914001549 homotetramer interface [polypeptide binding]; other site 759914001550 homodimer interface [polypeptide binding]; other site 759914001551 active site 759914001552 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 759914001553 pyruvate kinase; Provisional; Region: PRK05826 759914001554 domain interfaces; other site 759914001555 active site 759914001556 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 759914001557 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 759914001558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914001559 binding surface 759914001560 TPR motif; other site 759914001561 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 759914001562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001563 TPR motif; other site 759914001564 binding surface 759914001565 TPR repeat; Region: TPR_11; pfam13414 759914001566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001567 binding surface 759914001568 TPR motif; other site 759914001569 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 759914001570 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 759914001571 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 759914001572 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 759914001573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914001574 FeS/SAM binding site; other site 759914001575 Sporulation related domain; Region: SPOR; pfam05036 759914001576 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 759914001577 dephospho-CoA kinase; Region: TIGR00152 759914001578 CoA-binding site [chemical binding]; other site 759914001579 ATP-binding [chemical binding]; other site 759914001580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001581 binding surface 759914001582 TPR motif; other site 759914001583 cell division protein FtsZ; Validated; Region: PRK09330 759914001584 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 759914001585 nucleotide binding site [chemical binding]; other site 759914001586 SulA interaction site; other site 759914001587 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 759914001588 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 759914001589 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914001590 FeS/SAM binding site; other site 759914001591 GAF domain; Region: GAF_3; pfam13492 759914001592 GAF domain; Region: GAF_3; pfam13492 759914001593 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759914001594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759914001595 dimer interface [polypeptide binding]; other site 759914001596 phosphorylation site [posttranslational modification] 759914001597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759914001598 ATP binding site [chemical binding]; other site 759914001599 Mg2+ binding site [ion binding]; other site 759914001600 G-X-G motif; other site 759914001601 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 759914001602 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 759914001603 active site 759914001604 catalytic site [active] 759914001605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001606 TPR motif; other site 759914001607 binding surface 759914001608 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 759914001609 Methyltransferase domain; Region: Methyltransf_26; pfam13659 759914001610 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 759914001611 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 759914001612 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 759914001613 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759914001614 active site 759914001615 HIGH motif; other site 759914001616 nucleotide binding site [chemical binding]; other site 759914001617 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 759914001618 active site 759914001619 KMSKS motif; other site 759914001620 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 759914001621 tRNA binding surface [nucleotide binding]; other site 759914001622 anticodon binding site; other site 759914001623 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 759914001624 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 759914001625 putative RNA binding site [nucleotide binding]; other site 759914001626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001627 binding surface 759914001628 TPR motif; other site 759914001629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001630 TPR motif; other site 759914001631 binding surface 759914001632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001633 TPR motif; other site 759914001634 binding surface 759914001635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914001636 binding surface 759914001637 TPR motif; other site 759914001638 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 759914001639 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 759914001640 active site 759914001641 metal binding site [ion binding]; metal-binding site 759914001642 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 759914001643 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 759914001644 anti sigma factor interaction site; other site 759914001645 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 759914001646 regulatory phosphorylation site [posttranslational modification]; other site 759914001647 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 759914001648 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 759914001649 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 759914001650 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 759914001651 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 759914001652 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 759914001653 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 759914001654 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 759914001655 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 759914001656 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 759914001657 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 759914001658 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 759914001659 beta subunit interaction interface [polypeptide binding]; other site 759914001660 Walker A motif; other site 759914001661 ATP binding site [chemical binding]; other site 759914001662 Walker B motif; other site 759914001663 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 759914001664 Core-2/I-Branching enzyme; Region: Branch; pfam02485 759914001665 Core-2/I-Branching enzyme; Region: Branch; pfam02485 759914001666 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 759914001667 core domain interface [polypeptide binding]; other site 759914001668 delta subunit interface [polypeptide binding]; other site 759914001669 epsilon subunit interface [polypeptide binding]; other site 759914001670 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 759914001671 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 759914001672 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759914001673 catalytic residue [active] 759914001674 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759914001675 Zn2+ binding site [ion binding]; other site 759914001676 Mg2+ binding site [ion binding]; other site 759914001677 hypothetical protein; Provisional; Region: PRK13665 759914001678 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 759914001679 putative nucleotide binding site [chemical binding]; other site 759914001680 uridine monophosphate binding site [chemical binding]; other site 759914001681 homohexameric interface [polypeptide binding]; other site 759914001682 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 759914001683 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 759914001684 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759914001685 active site 759914001686 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 759914001687 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 759914001688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759914001689 ATP binding site [chemical binding]; other site 759914001690 putative Mg++ binding site [ion binding]; other site 759914001691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759914001692 nucleotide binding region [chemical binding]; other site 759914001693 ATP-binding site [chemical binding]; other site 759914001694 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914001695 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 759914001696 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 759914001697 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 759914001698 active site turn [active] 759914001699 phosphorylation site [posttranslational modification] 759914001700 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 759914001701 HPr interaction site; other site 759914001702 glycerol kinase (GK) interaction site [polypeptide binding]; other site 759914001703 active site 759914001704 phosphorylation site [posttranslational modification] 759914001705 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 759914001706 Catalytic site; other site 759914001707 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 759914001708 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 759914001709 thiamine phosphate binding site [chemical binding]; other site 759914001710 active site 759914001711 pyrophosphate binding site [ion binding]; other site 759914001712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914001713 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759914001714 Walker A motif; other site 759914001715 ATP binding site [chemical binding]; other site 759914001716 Walker B motif; other site 759914001717 arginine finger; other site 759914001718 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 759914001719 dimer interface [polypeptide binding]; other site 759914001720 putative tRNA-binding site [nucleotide binding]; other site 759914001721 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 759914001722 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 759914001723 NEF interaction site [polypeptide binding]; other site 759914001724 nucleotide binding site [chemical binding]; other site 759914001725 SBD interface [polypeptide binding]; other site 759914001726 GrpE; Region: GrpE; pfam01025 759914001727 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 759914001728 dimer interface [polypeptide binding]; other site 759914001729 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 759914001730 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 759914001731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914001732 Walker A motif; other site 759914001733 ATP binding site [chemical binding]; other site 759914001734 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 759914001735 DnaA box-binding interface [nucleotide binding]; other site 759914001736 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759914001737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914001738 dimer interface [polypeptide binding]; other site 759914001739 conserved gate region; other site 759914001740 ABC-ATPase subunit interface; other site 759914001741 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759914001742 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759914001743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914001744 dimer interface [polypeptide binding]; other site 759914001745 conserved gate region; other site 759914001746 putative PBP binding loops; other site 759914001747 ABC-ATPase subunit interface; other site 759914001748 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759914001749 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914001750 peptide binding site [polypeptide binding]; other site 759914001751 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 759914001752 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 759914001753 Cache domain; Region: Cache_1; pfam02743 759914001754 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914001755 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914001756 dimer interface [polypeptide binding]; other site 759914001757 putative CheW interface [polypeptide binding]; other site 759914001758 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 759914001759 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 759914001760 active site 759914001761 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 759914001762 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 759914001763 substrate binding site [chemical binding]; other site 759914001764 ATP binding site [chemical binding]; other site 759914001765 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 759914001766 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 759914001767 short chain dehydrogenase; Provisional; Region: PRK06940 759914001768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759914001769 NAD(P) binding site [chemical binding]; other site 759914001770 active site 759914001771 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 759914001772 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 759914001773 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 759914001774 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759914001775 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 759914001776 active site 759914001777 catalytic tetrad [active] 759914001778 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 759914001779 trimer interface [polypeptide binding]; other site 759914001780 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 759914001781 active site 759914001782 substrate binding site [chemical binding]; other site 759914001783 CoA binding site [chemical binding]; other site 759914001784 Uncharacterized conserved protein [Function unknown]; Region: COG4925 759914001785 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 759914001786 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 759914001787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759914001788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759914001789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 759914001790 dimerization interface [polypeptide binding]; other site 759914001791 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 759914001792 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 759914001793 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 759914001794 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759914001795 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 759914001796 active site 759914001797 catalytic tetrad [active] 759914001798 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759914001799 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 759914001800 active site 759914001801 catalytic tetrad [active] 759914001802 Uncharacterized conserved protein [Function unknown]; Region: COG4925 759914001803 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 759914001804 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 759914001805 DNA binding residues [nucleotide binding] 759914001806 putative dimer interface [polypeptide binding]; other site 759914001807 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 759914001808 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759914001809 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759914001810 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 759914001811 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 759914001812 Helix-turn-helix domain; Region: HTH_36; pfam13730 759914001813 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 759914001814 Homeodomain-like domain; Region: HTH_23; pfam13384 759914001815 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 759914001816 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 759914001817 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 759914001818 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 759914001819 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 759914001820 inhibitor-cofactor binding pocket; inhibition site 759914001821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914001822 catalytic residue [active] 759914001823 glycerate kinase; Region: TIGR00045 759914001824 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 759914001825 Na binding site [ion binding]; other site 759914001826 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 759914001827 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 759914001828 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 759914001829 putative acyltransferase; Provisional; Region: PRK05790 759914001830 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 759914001831 dimer interface [polypeptide binding]; other site 759914001832 active site 759914001833 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 759914001834 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 759914001835 NAD(P) binding site [chemical binding]; other site 759914001836 homotetramer interface [polypeptide binding]; other site 759914001837 homodimer interface [polypeptide binding]; other site 759914001838 active site 759914001839 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 759914001840 Coenzyme A transferase; Region: CoA_trans; smart00882 759914001841 Coenzyme A transferase; Region: CoA_trans; cl17247 759914001842 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 759914001843 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 759914001844 acyl-activating enzyme (AAE) consensus motif; other site 759914001845 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 759914001846 acyl-activating enzyme (AAE) consensus motif; other site 759914001847 putative AMP binding site [chemical binding]; other site 759914001848 putative active site [active] 759914001849 putative CoA binding site [chemical binding]; other site 759914001850 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 759914001851 MarR family; Region: MarR_2; pfam12802 759914001852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759914001853 active site 759914001854 phosphorylation site [posttranslational modification] 759914001855 intermolecular recognition site; other site 759914001856 dimerization interface [polypeptide binding]; other site 759914001857 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 759914001858 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 759914001859 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 759914001860 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 759914001861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759914001862 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 759914001863 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759914001864 DNA binding residues [nucleotide binding] 759914001865 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 759914001866 HemN C-terminal domain; Region: HemN_C; pfam06969 759914001867 Trp repressor protein; Region: Trp_repressor; cl17266 759914001868 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 759914001869 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 759914001870 anti sigma factor interaction site; other site 759914001871 regulatory phosphorylation site [posttranslational modification]; other site 759914001872 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 759914001873 active site 759914001874 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 759914001875 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 759914001876 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 759914001877 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 759914001878 nudix motif; other site 759914001879 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 759914001880 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 759914001881 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 759914001882 endonuclease III; Region: ENDO3c; smart00478 759914001883 minor groove reading motif; other site 759914001884 helix-hairpin-helix signature motif; other site 759914001885 substrate binding pocket [chemical binding]; other site 759914001886 active site 759914001887 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 759914001888 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 759914001889 triosephosphate isomerase; Provisional; Region: PRK14567 759914001890 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 759914001891 substrate binding site [chemical binding]; other site 759914001892 dimer interface [polypeptide binding]; other site 759914001893 catalytic triad [active] 759914001894 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 759914001895 Isochorismatase family; Region: Isochorismatase; pfam00857 759914001896 catalytic triad [active] 759914001897 dimer interface [polypeptide binding]; other site 759914001898 conserved cis-peptide bond; other site 759914001899 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 759914001900 cell division protein FtsA; Region: ftsA; TIGR01174 759914001901 Cell division protein FtsA; Region: FtsA; smart00842 759914001902 Cell division protein FtsA; Region: FtsA; pfam14450 759914001903 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 759914001904 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 759914001905 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 759914001906 putative active site [active] 759914001907 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 759914001908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759914001909 Coenzyme A binding pocket [chemical binding]; other site 759914001910 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 759914001911 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 759914001912 TIGR00159 family protein; Region: TIGR00159 759914001913 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 759914001914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 759914001915 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cl02206 759914001916 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 759914001917 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 759914001918 active site 759914001919 catalytic residues [active] 759914001920 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 759914001921 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 759914001922 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 759914001923 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 759914001924 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 759914001925 HSP70 interaction site [polypeptide binding]; other site 759914001926 von Willebrand factor type A domain; Region: VWA_2; pfam13519 759914001927 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 759914001928 metal-binding site [ion binding] 759914001929 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 759914001930 RuvA N terminal domain; Region: RuvA_N; pfam01330 759914001931 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 759914001932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759914001933 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759914001934 putative substrate translocation pore; other site 759914001935 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 759914001936 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 759914001937 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 759914001938 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 759914001939 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759914001940 Zn2+ binding site [ion binding]; other site 759914001941 Mg2+ binding site [ion binding]; other site 759914001942 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 759914001943 FlgD Tudor-like domain; Region: FLgD_tudor; cl17881 759914001944 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 759914001945 active site 759914001946 phosphorylation site [posttranslational modification] 759914001947 Putative zinc ribbon domain; Region: DUF164; pfam02591 759914001948 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 759914001949 elongation factor G; Reviewed; Region: PRK12740 759914001950 G1 box; other site 759914001951 putative GEF interaction site [polypeptide binding]; other site 759914001952 GTP/Mg2+ binding site [chemical binding]; other site 759914001953 Switch I region; other site 759914001954 G2 box; other site 759914001955 G3 box; other site 759914001956 Switch II region; other site 759914001957 G4 box; other site 759914001958 G5 box; other site 759914001959 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 759914001960 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 759914001961 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 759914001962 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 759914001963 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 759914001964 dimer interface [polypeptide binding]; other site 759914001965 active site 759914001966 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 759914001967 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 759914001968 DNA binding residues [nucleotide binding] 759914001969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914001970 binding surface 759914001971 TPR motif; other site 759914001972 TPR repeat; Region: TPR_11; pfam13414 759914001973 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914001974 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914001975 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914001976 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914001977 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914001978 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914001979 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914001980 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 759914001981 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 759914001982 Transcriptional regulators [Transcription]; Region: MarR; COG1846 759914001983 MarR family; Region: MarR_2; pfam12802 759914001984 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 759914001985 heme-binding site [chemical binding]; other site 759914001986 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 759914001987 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 759914001988 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 759914001989 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 759914001990 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 759914001991 substrate binding site [chemical binding]; other site 759914001992 oxyanion hole (OAH) forming residues; other site 759914001993 trimer interface [polypeptide binding]; other site 759914001994 putative acyltransferase; Provisional; Region: PRK05790 759914001995 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 759914001996 dimer interface [polypeptide binding]; other site 759914001997 active site 759914001998 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 759914001999 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 759914002000 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 759914002001 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 759914002002 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 759914002003 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 759914002004 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 759914002005 active site 759914002006 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 759914002007 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 759914002008 Rubredoxin [Energy production and conversion]; Region: COG1773 759914002009 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 759914002010 iron binding site [ion binding]; other site 759914002011 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 759914002012 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 759914002013 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 759914002014 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 759914002015 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 759914002016 XdhC Rossmann domain; Region: XdhC_C; pfam13478 759914002017 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 759914002018 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 759914002019 Ligand binding site; other site 759914002020 metal-binding site 759914002021 xanthine permease; Region: pbuX; TIGR03173 759914002022 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 759914002023 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 759914002024 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 759914002025 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 759914002026 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 759914002027 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 759914002028 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 759914002029 carbamate kinase; Reviewed; Region: PRK12686 759914002030 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 759914002031 putative substrate binding site [chemical binding]; other site 759914002032 nucleotide binding site [chemical binding]; other site 759914002033 nucleotide binding site [chemical binding]; other site 759914002034 homodimer interface [polypeptide binding]; other site 759914002035 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 759914002036 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 759914002037 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 759914002038 peptidase; Reviewed; Region: PRK13004 759914002039 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 759914002040 putative metal binding site [ion binding]; other site 759914002041 putative dimer interface [polypeptide binding]; other site 759914002042 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 759914002043 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 759914002044 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759914002045 catalytic residue [active] 759914002046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 759914002047 YheO-like PAS domain; Region: PAS_6; pfam08348 759914002048 HTH domain; Region: HTH_22; pfam13309 759914002049 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 759914002050 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759914002051 active site 759914002052 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 759914002053 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759914002054 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 759914002055 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 759914002056 catalytic loop [active] 759914002057 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 759914002058 iron binding site [ion binding]; other site 759914002059 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 759914002060 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 759914002061 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 759914002062 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 759914002063 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 759914002064 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002065 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914002066 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002067 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914002068 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002069 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002070 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914002071 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002072 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002073 Ankyrin repeat; Region: Ank; pfam00023 759914002074 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914002075 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002076 phenylhydantoinase; Validated; Region: PRK08323 759914002077 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 759914002078 tetramer interface [polypeptide binding]; other site 759914002079 active site 759914002080 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 759914002081 nucleotide binding site [chemical binding]; other site 759914002082 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 759914002083 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 759914002084 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 759914002085 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759914002086 catalytic residue [active] 759914002087 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 759914002088 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 759914002089 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 759914002090 Rubrerythrin [Energy production and conversion]; Region: COG1592 759914002091 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 759914002092 binuclear metal center [ion binding]; other site 759914002093 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 759914002094 iron binding site [ion binding]; other site 759914002095 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 759914002096 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 759914002097 dimer interface [polypeptide binding]; other site 759914002098 active site 759914002099 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759914002100 active site 759914002101 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 759914002102 LemA family; Region: LemA; cl00742 759914002103 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 759914002104 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 759914002105 HEAT repeats; Region: HEAT_2; pfam13646 759914002106 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 759914002107 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 759914002108 ligand binding site [chemical binding]; other site 759914002109 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 759914002110 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 759914002111 ligand binding site [chemical binding]; other site 759914002112 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914002113 FeS/SAM binding site; other site 759914002114 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 759914002115 FAD binding domain; Region: FAD_binding_4; pfam01565 759914002116 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 759914002117 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 759914002118 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 759914002119 putative NAD(P) binding site [chemical binding]; other site 759914002120 putative substrate binding site [chemical binding]; other site 759914002121 catalytic Zn binding site [ion binding]; other site 759914002122 structural Zn binding site [ion binding]; other site 759914002123 dimer interface [polypeptide binding]; other site 759914002124 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 759914002125 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 759914002126 active site 759914002127 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 759914002128 active site 759914002129 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 759914002130 EamA-like transporter family; Region: EamA; pfam00892 759914002131 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 759914002132 putative deacylase active site [active] 759914002133 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 759914002134 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 759914002135 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 759914002136 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 759914002137 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 759914002138 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 759914002139 Flagellar protein (FlbD); Region: FlbD; pfam06289 759914002140 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 759914002141 flagellar motor protein MotP; Reviewed; Region: PRK06926 759914002142 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 759914002143 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 759914002144 ligand binding site [chemical binding]; other site 759914002145 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 759914002146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914002147 S-adenosylmethionine binding site [chemical binding]; other site 759914002148 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 759914002149 translation initiation factor IF-2; Region: IF-2; TIGR00487 759914002150 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 759914002151 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 759914002152 G1 box; other site 759914002153 putative GEF interaction site [polypeptide binding]; other site 759914002154 GTP/Mg2+ binding site [chemical binding]; other site 759914002155 Switch I region; other site 759914002156 G2 box; other site 759914002157 G3 box; other site 759914002158 Switch II region; other site 759914002159 G4 box; other site 759914002160 G5 box; other site 759914002161 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 759914002162 Translation-initiation factor 2; Region: IF-2; pfam11987 759914002163 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 759914002164 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 759914002165 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 759914002166 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 759914002167 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 759914002168 active site 759914002169 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 759914002170 Uncharacterized conserved protein [Function unknown]; Region: COG2006 759914002171 Domain of unknown function (DUF362); Region: DUF362; pfam04015 759914002172 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 759914002173 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 759914002174 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 759914002175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 759914002176 Methyltransferase domain; Region: Methyltransf_23; pfam13489 759914002177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914002178 S-adenosylmethionine binding site [chemical binding]; other site 759914002179 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 759914002180 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 759914002181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759914002182 ATP binding site [chemical binding]; other site 759914002183 putative Mg++ binding site [ion binding]; other site 759914002184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759914002185 nucleotide binding region [chemical binding]; other site 759914002186 ATP-binding site [chemical binding]; other site 759914002187 TRCF domain; Region: TRCF; pfam03461 759914002188 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 759914002189 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 759914002190 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 759914002191 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759914002192 RNA binding surface [nucleotide binding]; other site 759914002193 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 759914002194 active site 759914002195 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 759914002196 dimerization interface [polypeptide binding]; other site 759914002197 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914002198 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914002199 dimer interface [polypeptide binding]; other site 759914002200 putative CheW interface [polypeptide binding]; other site 759914002201 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 759914002202 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 759914002203 putative active site [active] 759914002204 metal binding site [ion binding]; metal-binding site 759914002205 inner membrane protein; Provisional; Region: PRK11715 759914002206 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914002207 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 759914002208 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 759914002209 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914002210 Biotin operon repressor [Transcription]; Region: BirA; COG1654 759914002211 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 759914002212 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 759914002213 biotin synthase; Region: bioB; TIGR00433 759914002214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914002215 FeS/SAM binding site; other site 759914002216 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 759914002217 AAA domain; Region: AAA_26; pfam13500 759914002218 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 759914002219 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 759914002220 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 759914002221 inhibitor-cofactor binding pocket; inhibition site 759914002222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914002223 catalytic residue [active] 759914002224 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759914002225 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914002226 peptide binding site [polypeptide binding]; other site 759914002227 TfoX N-terminal domain; Region: TfoX_N; pfam04993 759914002228 seryl-tRNA synthetase; Provisional; Region: PRK05431 759914002229 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 759914002230 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 759914002231 dimer interface [polypeptide binding]; other site 759914002232 active site 759914002233 motif 1; other site 759914002234 motif 2; other site 759914002235 motif 3; other site 759914002236 Rubrerythrin [Energy production and conversion]; Region: COG1592 759914002237 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 759914002238 binuclear metal center [ion binding]; other site 759914002239 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 759914002240 iron binding site [ion binding]; other site 759914002241 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 759914002242 amphipathic channel; other site 759914002243 Asn-Pro-Ala signature motifs; other site 759914002244 glycerol kinase; Provisional; Region: glpK; PRK00047 759914002245 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 759914002246 N- and C-terminal domain interface [polypeptide binding]; other site 759914002247 active site 759914002248 MgATP binding site [chemical binding]; other site 759914002249 catalytic site [active] 759914002250 metal binding site [ion binding]; metal-binding site 759914002251 glycerol binding site [chemical binding]; other site 759914002252 homotetramer interface [polypeptide binding]; other site 759914002253 homodimer interface [polypeptide binding]; other site 759914002254 FBP binding site [chemical binding]; other site 759914002255 protein IIAGlc interface [polypeptide binding]; other site 759914002256 Predicted dehydrogenase [General function prediction only]; Region: COG0579 759914002257 hydroxyglutarate oxidase; Provisional; Region: PRK11728 759914002258 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 759914002259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 759914002260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759914002261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759914002262 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 759914002263 active site 759914002264 Mn binding site [ion binding]; other site 759914002265 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 759914002266 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 759914002267 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 759914002268 active site 759914002269 NTP binding site [chemical binding]; other site 759914002270 metal binding triad [ion binding]; metal-binding site 759914002271 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 759914002272 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759914002273 Zn2+ binding site [ion binding]; other site 759914002274 Mg2+ binding site [ion binding]; other site 759914002275 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 759914002276 Type III pantothenate kinase; Region: Pan_kinase; pfam03309 759914002277 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 759914002278 dimerization domain swap beta strand [polypeptide binding]; other site 759914002279 regulatory protein interface [polypeptide binding]; other site 759914002280 active site 759914002281 regulatory phosphorylation site [posttranslational modification]; other site 759914002282 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 759914002283 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 759914002284 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 759914002285 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 759914002286 Peptidase M30; Region: Peptidase_M30; pfam10460 759914002287 flavodoxin; Provisional; Region: PRK06242 759914002288 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 759914002289 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759914002290 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914002291 peptide binding site [polypeptide binding]; other site 759914002292 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759914002293 active site 759914002294 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 759914002295 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 759914002296 nucleotide binding pocket [chemical binding]; other site 759914002297 K-X-D-G motif; other site 759914002298 catalytic site [active] 759914002299 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 759914002300 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 759914002301 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 759914002302 Dimer interface [polypeptide binding]; other site 759914002303 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 759914002304 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 759914002305 DNA binding residues [nucleotide binding] 759914002306 Response regulator receiver domain; Region: Response_reg; pfam00072 759914002307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759914002308 active site 759914002309 phosphorylation site [posttranslational modification] 759914002310 intermolecular recognition site; other site 759914002311 dimerization interface [polypeptide binding]; other site 759914002312 primosome assembly protein PriA; Validated; Region: PRK05580 759914002313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759914002314 ATP binding site [chemical binding]; other site 759914002315 putative Mg++ binding site [ion binding]; other site 759914002316 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759914002317 ATP-binding site [chemical binding]; other site 759914002318 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 759914002319 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 759914002320 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 759914002321 23S rRNA interface [nucleotide binding]; other site 759914002322 L3 interface [polypeptide binding]; other site 759914002323 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 759914002324 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 759914002325 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 759914002326 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 759914002327 dimerization interface 3.5A [polypeptide binding]; other site 759914002328 active site 759914002329 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 759914002330 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 759914002331 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 759914002332 protein binding site [polypeptide binding]; other site 759914002333 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 759914002334 protein binding site [polypeptide binding]; other site 759914002335 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 759914002336 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 759914002337 putative acyl-acceptor binding pocket; other site 759914002338 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 759914002339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759914002340 NAD(P) binding site [chemical binding]; other site 759914002341 active site 759914002342 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 759914002343 TrkA-N domain; Region: TrkA_N; pfam02254 759914002344 TrkA-C domain; Region: TrkA_C; pfam02080 759914002345 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 759914002346 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 759914002347 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 759914002348 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 759914002349 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 759914002350 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 759914002351 rarD protein; Region: rarD; TIGR00688 759914002352 Rubrerythrin [Energy production and conversion]; Region: COG1592 759914002353 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 759914002354 binuclear metal center [ion binding]; other site 759914002355 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 759914002356 iron binding site [ion binding]; other site 759914002357 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 759914002358 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 759914002359 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 759914002360 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 759914002361 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 759914002362 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 759914002363 RNA/DNA hybrid binding site [nucleotide binding]; other site 759914002364 active site 759914002365 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 759914002366 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759914002367 Zn2+ binding site [ion binding]; other site 759914002368 Mg2+ binding site [ion binding]; other site 759914002369 hypothetical protein; Reviewed; Region: PRK12497 759914002370 KpsF/GutQ family protein; Region: kpsF; TIGR00393 759914002371 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 759914002372 putative active site [active] 759914002373 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 759914002374 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 759914002375 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 759914002376 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 759914002377 putative active site [active] 759914002378 catalytic site [active] 759914002379 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 759914002380 putative active site [active] 759914002381 catalytic site [active] 759914002382 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 759914002383 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 759914002384 RNB domain; Region: RNB; pfam00773 759914002385 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 759914002386 RNA binding site [nucleotide binding]; other site 759914002387 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914002388 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002389 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002390 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914002391 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002392 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002393 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914002394 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002395 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914002396 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002397 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002398 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914002399 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914002400 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 759914002401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914002402 Walker A motif; other site 759914002403 ATP binding site [chemical binding]; other site 759914002404 Walker B motif; other site 759914002405 arginine finger; other site 759914002406 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 759914002407 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 759914002408 Peptidase family M23; Region: Peptidase_M23; pfam01551 759914002409 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 759914002410 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 759914002411 Na binding site [ion binding]; other site 759914002412 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 759914002413 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 759914002414 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 759914002415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914002416 FeS/SAM binding site; other site 759914002417 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 759914002418 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 759914002419 Sulfatase; Region: Sulfatase; pfam00884 759914002420 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 759914002421 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 759914002422 Sulfatase; Region: Sulfatase; pfam00884 759914002423 Sulfatase; Region: Sulfatase; cl17466 759914002424 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 759914002425 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 759914002426 Sulfatase; Region: Sulfatase; pfam00884 759914002427 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 759914002428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759914002429 DNA binding residues [nucleotide binding] 759914002430 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 759914002431 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 759914002432 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 759914002433 YceG-like family; Region: YceG; pfam02618 759914002434 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 759914002435 dimerization interface [polypeptide binding]; other site 759914002436 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 759914002437 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 759914002438 dimer interface [polypeptide binding]; other site 759914002439 active site 759914002440 metal binding site [ion binding]; metal-binding site 759914002441 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 759914002442 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 759914002443 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 759914002444 trimer interface [polypeptide binding]; other site 759914002445 active site 759914002446 substrate binding site [chemical binding]; other site 759914002447 CoA binding site [chemical binding]; other site 759914002448 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 759914002449 active site 759914002450 AAA domain; Region: AAA_21; pfam13304 759914002451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914002452 Q-loop/lid; other site 759914002453 ABC transporter signature motif; other site 759914002454 Walker B; other site 759914002455 D-loop; other site 759914002456 H-loop/switch region; other site 759914002457 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 759914002458 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 759914002459 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759914002460 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914002461 peptide binding site [polypeptide binding]; other site 759914002462 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 759914002463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759914002464 putative substrate translocation pore; other site 759914002465 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 759914002466 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 759914002467 putative ribose interaction site [chemical binding]; other site 759914002468 putative ADP binding site [chemical binding]; other site 759914002469 Protein of unknown function (DUF342); Region: DUF342; pfam03961 759914002470 Methyltransferase domain; Region: Methyltransf_23; pfam13489 759914002471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914002472 S-adenosylmethionine binding site [chemical binding]; other site 759914002473 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 759914002474 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 759914002475 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 759914002476 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 759914002477 putative active site [active] 759914002478 substrate binding site [chemical binding]; other site 759914002479 putative cosubstrate binding site; other site 759914002480 catalytic site [active] 759914002481 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 759914002482 substrate binding site [chemical binding]; other site 759914002483 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 759914002484 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 759914002485 Chloramphenicol acetyltransferase; Region: CAT; cl02008 759914002486 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 759914002487 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759914002488 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 759914002489 active site 759914002490 catalytic tetrad [active] 759914002491 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 759914002492 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 759914002493 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 759914002494 acyl-activating enzyme (AAE) consensus motif; other site 759914002495 AMP binding site [chemical binding]; other site 759914002496 active site 759914002497 CoA binding site [chemical binding]; other site 759914002498 Haemolysin-III related; Region: HlyIII; cl03831 759914002499 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 759914002500 active site 759914002501 catalytic residues [active] 759914002502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914002503 active site 759914002504 motif I; other site 759914002505 motif II; other site 759914002506 pyruvate phosphate dikinase; Provisional; Region: PRK09279 759914002507 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 759914002508 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 759914002509 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 759914002510 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 759914002511 histidinol-phosphatase; Reviewed; Region: PRK08123 759914002512 active site 759914002513 dimer interface [polypeptide binding]; other site 759914002514 Rod binding protein; Region: Rod-binding; pfam10135 759914002515 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914002516 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914002517 dimer interface [polypeptide binding]; other site 759914002518 putative CheW interface [polypeptide binding]; other site 759914002519 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 759914002520 MviN-like protein; Region: MVIN; pfam03023 759914002521 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 759914002522 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 759914002523 6-phosphofructokinase; Provisional; Region: PRK03202 759914002524 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 759914002525 active site 759914002526 ADP/pyrophosphate binding site [chemical binding]; other site 759914002527 dimerization interface [polypeptide binding]; other site 759914002528 allosteric effector site; other site 759914002529 fructose-1,6-bisphosphate binding site; other site 759914002530 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 759914002531 MgtE intracellular N domain; Region: MgtE_N; smart00924 759914002532 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 759914002533 Divalent cation transporter; Region: MgtE; pfam01769 759914002534 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 759914002535 FtsX-like permease family; Region: FtsX; pfam02687 759914002536 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759914002537 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759914002538 Walker A/P-loop; other site 759914002539 ATP binding site [chemical binding]; other site 759914002540 Q-loop/lid; other site 759914002541 ABC transporter signature motif; other site 759914002542 Walker B; other site 759914002543 D-loop; other site 759914002544 H-loop/switch region; other site 759914002545 Predicted transcriptional regulators [Transcription]; Region: COG1695 759914002546 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 759914002547 ABC-2 type transporter; Region: ABC2_membrane; cl17235 759914002548 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 759914002549 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 759914002550 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 759914002551 Walker A/P-loop; other site 759914002552 ATP binding site [chemical binding]; other site 759914002553 Q-loop/lid; other site 759914002554 ABC transporter signature motif; other site 759914002555 Walker B; other site 759914002556 D-loop; other site 759914002557 H-loop/switch region; other site 759914002558 YcaO-like family; Region: YcaO; pfam02624 759914002559 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 759914002560 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 759914002561 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 759914002562 NADPH bind site [chemical binding]; other site 759914002563 putative FMN binding site [chemical binding]; other site 759914002564 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 759914002565 dimerization interface [polypeptide binding]; other site 759914002566 putative active cleft [active] 759914002567 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 759914002568 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 759914002569 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 759914002570 catalytic site [active] 759914002571 BNR repeat-like domain; Region: BNR_2; pfam13088 759914002572 Asp-box motif; other site 759914002573 N-acetylneuraminate lyase; Provisional; Region: PRK04147 759914002574 Class I aldolases; Region: Aldolase_Class_I; cl17187 759914002575 catalytic residue [active] 759914002576 Domain of unknown function (DUF386); Region: DUF386; cl01047 759914002577 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 759914002578 Na binding site [ion binding]; other site 759914002579 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 759914002580 Galactose oxidase, central domain; Region: Kelch_3; cl02701 759914002581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914002582 S-adenosylmethionine binding site [chemical binding]; other site 759914002583 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 759914002584 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 759914002585 gating phenylalanine in ion channel; other site 759914002586 hypothetical protein; Region: PHA00684 759914002587 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 759914002588 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 759914002589 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 759914002590 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 759914002591 active site 759914002592 HIGH motif; other site 759914002593 KMSKS motif; other site 759914002594 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 759914002595 tRNA binding surface [nucleotide binding]; other site 759914002596 anticodon binding site; other site 759914002597 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 759914002598 dimer interface [polypeptide binding]; other site 759914002599 putative tRNA-binding site [nucleotide binding]; other site 759914002600 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 759914002601 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 759914002602 dimer interface [polypeptide binding]; other site 759914002603 PYR/PP interface [polypeptide binding]; other site 759914002604 TPP binding site [chemical binding]; other site 759914002605 substrate binding site [chemical binding]; other site 759914002606 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 759914002607 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 759914002608 TPP-binding site [chemical binding]; other site 759914002609 putative dimer interface [polypeptide binding]; other site 759914002610 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 759914002611 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 759914002612 4Fe-4S binding domain; Region: Fer4; cl02805 759914002613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 759914002614 dimerization interface [polypeptide binding]; other site 759914002615 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914002616 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914002617 dimer interface [polypeptide binding]; other site 759914002618 putative CheW interface [polypeptide binding]; other site 759914002619 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 759914002620 monogalactosyldiacylglycerol synthase; Region: PLN02605 759914002621 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 759914002622 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 759914002623 aspartate kinase; Reviewed; Region: PRK09034 759914002624 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 759914002625 nucleotide binding site [chemical binding]; other site 759914002626 substrate binding site [chemical binding]; other site 759914002627 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 759914002628 allosteric regulatory residue; other site 759914002629 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 759914002630 Uncharacterized conserved protein [Function unknown]; Region: COG3339 759914002631 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 759914002632 active site 759914002633 phosphorylation site [posttranslational modification] 759914002634 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 759914002635 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 759914002636 Ligand binding site; other site 759914002637 oligomer interface; other site 759914002638 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 759914002639 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 759914002640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759914002641 ATP binding site [chemical binding]; other site 759914002642 putative Mg++ binding site [ion binding]; other site 759914002643 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759914002644 nucleotide binding region [chemical binding]; other site 759914002645 ATP-binding site [chemical binding]; other site 759914002646 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 759914002647 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 759914002648 dimer interface [polypeptide binding]; other site 759914002649 ssDNA binding site [nucleotide binding]; other site 759914002650 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759914002651 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 759914002652 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 759914002653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914002654 binding surface 759914002655 TPR motif; other site 759914002656 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 759914002657 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 759914002658 Flagellar protein FliS; Region: FliS; cl00654 759914002659 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 759914002660 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 759914002661 substrate binding [chemical binding]; other site 759914002662 active site 759914002663 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 759914002664 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 759914002665 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 759914002666 active site turn [active] 759914002667 phosphorylation site [posttranslational modification] 759914002668 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 759914002669 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759914002670 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759914002671 DNA binding site [nucleotide binding] 759914002672 domain linker motif; other site 759914002673 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 759914002674 dimerization interface [polypeptide binding]; other site 759914002675 ligand binding site [chemical binding]; other site 759914002676 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 759914002677 ligand binding site [chemical binding]; other site 759914002678 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 759914002679 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759914002680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914002681 homodimer interface [polypeptide binding]; other site 759914002682 catalytic residue [active] 759914002683 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 759914002684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914002685 Walker A motif; other site 759914002686 ATP binding site [chemical binding]; other site 759914002687 Walker B motif; other site 759914002688 arginine finger; other site 759914002689 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 759914002690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 759914002691 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 759914002692 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 759914002693 GDP-binding site [chemical binding]; other site 759914002694 ACT binding site; other site 759914002695 IMP binding site; other site 759914002696 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 759914002697 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 759914002698 DctM-like transporters; Region: DctM; pfam06808 759914002699 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 759914002700 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 759914002701 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 759914002702 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 759914002703 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759914002704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759914002705 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 759914002706 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 759914002707 active site residue [active] 759914002708 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 759914002709 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 759914002710 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 759914002711 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 759914002712 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 759914002713 RNB domain; Region: RNB; pfam00773 759914002714 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 759914002715 RNA binding site [nucleotide binding]; other site 759914002716 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 759914002717 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 759914002718 Walker A/P-loop; other site 759914002719 ATP binding site [chemical binding]; other site 759914002720 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 759914002721 ABC transporter signature motif; other site 759914002722 Walker B; other site 759914002723 D-loop; other site 759914002724 H-loop/switch region; other site 759914002725 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 759914002726 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759914002727 catalytic core [active] 759914002728 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759914002729 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 759914002730 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 759914002731 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 759914002732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914002733 TPR motif; other site 759914002734 binding surface 759914002735 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914002736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914002737 binding surface 759914002738 TPR motif; other site 759914002739 TPR repeat; Region: TPR_11; pfam13414 759914002740 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759914002741 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759914002742 substrate binding pocket [chemical binding]; other site 759914002743 membrane-bound complex binding site; other site 759914002744 hinge residues; other site 759914002745 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759914002746 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759914002747 substrate binding pocket [chemical binding]; other site 759914002748 membrane-bound complex binding site; other site 759914002749 hinge residues; other site 759914002750 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759914002751 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759914002752 substrate binding pocket [chemical binding]; other site 759914002753 membrane-bound complex binding site; other site 759914002754 hinge residues; other site 759914002755 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 759914002756 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 759914002757 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 759914002758 carboxyltransferase (CT) interaction site; other site 759914002759 biotinylation site [posttranslational modification]; other site 759914002760 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 759914002761 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 759914002762 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 759914002763 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 759914002764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914002765 Walker A motif; other site 759914002766 ATP binding site [chemical binding]; other site 759914002767 Walker B motif; other site 759914002768 arginine finger; other site 759914002769 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 759914002770 Smr domain; Region: Smr; pfam01713 759914002771 transcription termination factor Rho; Provisional; Region: rho; PRK09376 759914002772 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 759914002773 RNA binding site [nucleotide binding]; other site 759914002774 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 759914002775 Walker A motif; other site 759914002776 ATP binding site [chemical binding]; other site 759914002777 Walker B motif; other site 759914002778 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 759914002779 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 759914002780 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 759914002781 alphaNTD - beta interaction site [polypeptide binding]; other site 759914002782 alphaNTD homodimer interface [polypeptide binding]; other site 759914002783 alphaNTD - beta' interaction site [polypeptide binding]; other site 759914002784 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 759914002785 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 759914002786 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 759914002787 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759914002788 RNA binding surface [nucleotide binding]; other site 759914002789 30S ribosomal protein S11; Validated; Region: PRK05309 759914002790 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 759914002791 30S ribosomal protein S13; Region: bact_S13; TIGR03631 759914002792 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 759914002793 rRNA binding site [nucleotide binding]; other site 759914002794 predicted 30S ribosome binding site; other site 759914002795 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 759914002796 SecY translocase; Region: SecY; pfam00344 759914002797 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 759914002798 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 759914002799 23S rRNA binding site [nucleotide binding]; other site 759914002800 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 759914002801 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 759914002802 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 759914002803 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 759914002804 5S rRNA interface [nucleotide binding]; other site 759914002805 23S rRNA interface [nucleotide binding]; other site 759914002806 L5 interface [polypeptide binding]; other site 759914002807 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 759914002808 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 759914002809 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 759914002810 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 759914002811 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 759914002812 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 759914002813 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 759914002814 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 759914002815 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 759914002816 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 759914002817 RNA binding site [nucleotide binding]; other site 759914002818 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 759914002819 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 759914002820 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 759914002821 L23 interface [polypeptide binding]; other site 759914002822 trigger factor interaction site; other site 759914002823 23S rRNA interface [nucleotide binding]; other site 759914002824 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 759914002825 23S rRNA interface [nucleotide binding]; other site 759914002826 5S rRNA interface [nucleotide binding]; other site 759914002827 putative antibiotic binding site [chemical binding]; other site 759914002828 L25 interface [polypeptide binding]; other site 759914002829 L27 interface [polypeptide binding]; other site 759914002830 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 759914002831 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 759914002832 G-X-X-G motif; other site 759914002833 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 759914002834 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 759914002835 protein-rRNA interface [nucleotide binding]; other site 759914002836 putative translocon binding site; other site 759914002837 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 759914002838 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 759914002839 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 759914002840 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 759914002841 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 759914002842 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 759914002843 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 759914002844 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 759914002845 elongation factor Tu; Reviewed; Region: PRK00049 759914002846 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 759914002847 G1 box; other site 759914002848 GEF interaction site [polypeptide binding]; other site 759914002849 GTP/Mg2+ binding site [chemical binding]; other site 759914002850 Switch I region; other site 759914002851 G2 box; other site 759914002852 G3 box; other site 759914002853 Switch II region; other site 759914002854 G4 box; other site 759914002855 G5 box; other site 759914002856 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 759914002857 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 759914002858 Antibiotic Binding Site [chemical binding]; other site 759914002859 elongation factor G; Reviewed; Region: PRK00007 759914002860 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 759914002861 G1 box; other site 759914002862 putative GEF interaction site [polypeptide binding]; other site 759914002863 GTP/Mg2+ binding site [chemical binding]; other site 759914002864 Switch I region; other site 759914002865 G2 box; other site 759914002866 G3 box; other site 759914002867 Switch II region; other site 759914002868 G4 box; other site 759914002869 G5 box; other site 759914002870 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 759914002871 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 759914002872 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 759914002873 30S ribosomal protein S7; Validated; Region: PRK05302 759914002874 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 759914002875 16S rRNA interaction site [nucleotide binding]; other site 759914002876 streptomycin interaction site [chemical binding]; other site 759914002877 23S rRNA interaction site [nucleotide binding]; other site 759914002878 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 759914002879 V-type ATP synthase subunit K; Validated; Region: PRK06558 759914002880 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 759914002881 V-type ATP synthase subunit I; Validated; Region: PRK05771 759914002882 V-type ATP synthase subunit D; Provisional; Region: PRK02195 759914002883 V-type ATP synthase subunit B; Provisional; Region: PRK02118 759914002884 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 759914002885 Walker A motif homologous position; other site 759914002886 Walker B motif; other site 759914002887 V-type ATP synthase subunit A; Provisional; Region: PRK04192 759914002888 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 759914002889 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 759914002890 Walker A motif/ATP binding site; other site 759914002891 Walker B motif; other site 759914002892 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 759914002893 V-type ATP synthase subunit E; Provisional; Region: PRK01005 759914002894 V-type ATP synthase subunit E; Provisional; Region: PRK01558 759914002895 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 759914002896 substrate-binding tunnel; other site 759914002897 dimer interaction site [polypeptide binding]; other site 759914002898 substrate binding site [chemical binding]; other site 759914002899 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 759914002900 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 759914002901 FAD binding site [chemical binding]; other site 759914002902 homotetramer interface [polypeptide binding]; other site 759914002903 substrate binding pocket [chemical binding]; other site 759914002904 catalytic base [active] 759914002905 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 759914002906 Ligand binding site [chemical binding]; other site 759914002907 Electron transfer flavoprotein domain; Region: ETF; pfam01012 759914002908 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 759914002909 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 759914002910 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 759914002911 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759914002912 active site 759914002913 TonB C terminal; Region: TonB_2; pfam13103 759914002914 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 759914002915 ApbE family; Region: ApbE; pfam02424 759914002916 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 759914002917 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 759914002918 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 759914002919 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 759914002920 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 759914002921 putative active site [active] 759914002922 rod shape-determining protein MreC; Provisional; Region: PRK13922 759914002923 rod shape-determining protein MreC; Region: MreC; pfam04085 759914002924 rod shape-determining protein MreB; Provisional; Region: PRK13927 759914002925 MreB and similar proteins; Region: MreB_like; cd10225 759914002926 nucleotide binding site [chemical binding]; other site 759914002927 Mg binding site [ion binding]; other site 759914002928 putative protofilament interaction site [polypeptide binding]; other site 759914002929 RodZ interaction site [polypeptide binding]; other site 759914002930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914002931 TPR motif; other site 759914002932 binding surface 759914002933 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914002934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914002935 binding surface 759914002936 TPR motif; other site 759914002937 TPR repeat; Region: TPR_11; pfam13414 759914002938 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 759914002939 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 759914002940 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 759914002941 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 759914002942 Response regulator receiver domain; Region: Response_reg; pfam00072 759914002943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759914002944 active site 759914002945 phosphorylation site [posttranslational modification] 759914002946 intermolecular recognition site; other site 759914002947 dimerization interface [polypeptide binding]; other site 759914002948 elongation factor P; Validated; Region: PRK00529 759914002949 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 759914002950 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 759914002951 RNA binding site [nucleotide binding]; other site 759914002952 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 759914002953 RNA binding site [nucleotide binding]; other site 759914002954 MoxR-like ATPases [General function prediction only]; Region: COG0714 759914002955 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 759914002956 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 759914002957 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 759914002958 active site 759914002959 NAD binding site [chemical binding]; other site 759914002960 metal binding site [ion binding]; metal-binding site 759914002961 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 759914002962 RNase_H superfamily; Region: RNase_H_2; pfam13482 759914002963 active site 759914002964 substrate binding site [chemical binding]; other site 759914002965 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 759914002966 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 759914002967 active site 759914002968 HIGH motif; other site 759914002969 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 759914002970 KMSKS motif; other site 759914002971 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 759914002972 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 759914002973 DinB family; Region: DinB; cl17821 759914002974 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 759914002975 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 759914002976 FAD binding pocket [chemical binding]; other site 759914002977 FAD binding motif [chemical binding]; other site 759914002978 phosphate binding motif [ion binding]; other site 759914002979 beta-alpha-beta structure motif; other site 759914002980 NAD binding pocket [chemical binding]; other site 759914002981 Iron coordination center [ion binding]; other site 759914002982 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 759914002983 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 759914002984 heterodimer interface [polypeptide binding]; other site 759914002985 active site 759914002986 FMN binding site [chemical binding]; other site 759914002987 homodimer interface [polypeptide binding]; other site 759914002988 substrate binding site [chemical binding]; other site 759914002989 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 759914002990 active site 759914002991 dimer interface [polypeptide binding]; other site 759914002992 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759914002993 active site 759914002994 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 759914002995 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 759914002996 ADP binding site [chemical binding]; other site 759914002997 magnesium binding site [ion binding]; other site 759914002998 putative shikimate binding site; other site 759914002999 Chorismate mutase type II; Region: CM_2; smart00830 759914003000 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 759914003001 Prephenate dehydratase; Region: PDT; pfam00800 759914003002 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 759914003003 putative L-Phe binding site [chemical binding]; other site 759914003004 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 759914003005 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 759914003006 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 759914003007 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 759914003008 Ligand binding site; other site 759914003009 metal-binding site 759914003010 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 759914003011 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 759914003012 putative active site [active] 759914003013 metal binding site [ion binding]; metal-binding site 759914003014 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 759914003015 heterotetramer interface [polypeptide binding]; other site 759914003016 active site pocket [active] 759914003017 cleavage site 759914003018 Transglycosylase; Region: Transgly; pfam00912 759914003019 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 759914003020 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 759914003021 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 759914003022 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 759914003023 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 759914003024 active site 759914003025 phosphorylation site [posttranslational modification] 759914003026 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 759914003027 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 759914003028 PYR/PP interface [polypeptide binding]; other site 759914003029 dimer interface [polypeptide binding]; other site 759914003030 TPP binding site [chemical binding]; other site 759914003031 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 759914003032 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 759914003033 TPP-binding site [chemical binding]; other site 759914003034 dimer interface [polypeptide binding]; other site 759914003035 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 759914003036 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 759914003037 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 759914003038 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 759914003039 MoxR-like ATPases [General function prediction only]; Region: COG0714 759914003040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914003041 Walker A motif; other site 759914003042 ATP binding site [chemical binding]; other site 759914003043 Walker B motif; other site 759914003044 arginine finger; other site 759914003045 Oxygen tolerance; Region: BatD; pfam13584 759914003046 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 759914003047 active site 759914003048 intersubunit interactions; other site 759914003049 catalytic residue [active] 759914003050 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 759914003051 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 759914003052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914003053 binding surface 759914003054 TPR motif; other site 759914003055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914003056 TPR motif; other site 759914003057 binding surface 759914003058 MoxR-like ATPases [General function prediction only]; Region: COG0714 759914003059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914003060 Walker A motif; other site 759914003061 ATP binding site [chemical binding]; other site 759914003062 Walker B motif; other site 759914003063 arginine finger; other site 759914003064 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 759914003065 metal ion-dependent adhesion site (MIDAS); other site 759914003066 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 759914003067 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 759914003068 Ligand Binding Site [chemical binding]; other site 759914003069 TilS substrate C-terminal domain; Region: TilS_C; smart00977 759914003070 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 759914003071 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 759914003072 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 759914003073 active site 759914003074 HIGH motif; other site 759914003075 KMSK motif region; other site 759914003076 tRNA binding surface [nucleotide binding]; other site 759914003077 DALR anticodon binding domain; Region: DALR_1; smart00836 759914003078 anticodon binding site; other site 759914003079 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 759914003080 Protein of unknown function (DUF454); Region: DUF454; cl01063 759914003081 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 759914003082 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 759914003083 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 759914003084 Walker A/P-loop; other site 759914003085 ATP binding site [chemical binding]; other site 759914003086 Q-loop/lid; other site 759914003087 ABC transporter signature motif; other site 759914003088 Walker B; other site 759914003089 D-loop; other site 759914003090 H-loop/switch region; other site 759914003091 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 759914003092 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 759914003093 Walker A/P-loop; other site 759914003094 ATP binding site [chemical binding]; other site 759914003095 Q-loop/lid; other site 759914003096 ABC transporter signature motif; other site 759914003097 Walker B; other site 759914003098 D-loop; other site 759914003099 H-loop/switch region; other site 759914003100 Protein of unknown function (DUF523); Region: DUF523; cl00733 759914003101 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 759914003102 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 759914003103 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 759914003104 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 759914003105 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 759914003106 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 759914003107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 759914003108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759914003109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759914003110 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 759914003111 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759914003112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914003113 Walker A/P-loop; other site 759914003114 ATP binding site [chemical binding]; other site 759914003115 Q-loop/lid; other site 759914003116 ABC transporter signature motif; other site 759914003117 Walker B; other site 759914003118 D-loop; other site 759914003119 H-loop/switch region; other site 759914003120 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 759914003121 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759914003122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914003123 Walker A/P-loop; other site 759914003124 ATP binding site [chemical binding]; other site 759914003125 Q-loop/lid; other site 759914003126 ABC transporter signature motif; other site 759914003127 Walker B; other site 759914003128 D-loop; other site 759914003129 H-loop/switch region; other site 759914003130 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 759914003131 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 759914003132 active site 759914003133 phosphorylation site [posttranslational modification] 759914003134 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 759914003135 active site 759914003136 P-loop; other site 759914003137 phosphorylation site [posttranslational modification] 759914003138 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 759914003139 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 759914003140 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 759914003141 putative substrate binding site [chemical binding]; other site 759914003142 putative ATP binding site [chemical binding]; other site 759914003143 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 759914003144 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 759914003145 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 759914003146 multifunctional aminopeptidase A; Provisional; Region: PRK00913 759914003147 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 759914003148 interface (dimer of trimers) [polypeptide binding]; other site 759914003149 Substrate-binding/catalytic site; other site 759914003150 Zn-binding sites [ion binding]; other site 759914003151 Late competence development protein ComFB; Region: ComFB; pfam10719 759914003152 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 759914003153 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 759914003154 ATP binding site [chemical binding]; other site 759914003155 active site 759914003156 substrate binding site [chemical binding]; other site 759914003157 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 759914003158 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 759914003159 Class I aldolases; Region: Aldolase_Class_I; cl17187 759914003160 catalytic residue [active] 759914003161 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 759914003162 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 759914003163 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 759914003164 active site 759914003165 alpha-glucosidase; Provisional; Region: PRK10426 759914003166 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 759914003167 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 759914003168 putative active site [active] 759914003169 putative catalytic site [active] 759914003170 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 759914003171 hexamer (dimer of trimers) interface [polypeptide binding]; other site 759914003172 substrate binding site [chemical binding]; other site 759914003173 trimer interface [polypeptide binding]; other site 759914003174 Mn binding site [ion binding]; other site 759914003175 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 759914003176 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 759914003177 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 759914003178 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 759914003179 DctM-like transporters; Region: DctM; pfam06808 759914003180 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 759914003181 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759914003182 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759914003183 DNA binding site [nucleotide binding] 759914003184 domain linker motif; other site 759914003185 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759914003186 dimerization interface [polypeptide binding]; other site 759914003187 ligand binding site [chemical binding]; other site 759914003188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759914003189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759914003190 Outer membrane efflux protein; Region: OEP; pfam02321 759914003191 Outer membrane efflux protein; Region: OEP; pfam02321 759914003192 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 759914003193 Protein export membrane protein; Region: SecD_SecF; cl14618 759914003194 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 759914003195 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 759914003196 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 759914003197 dimer interface [polypeptide binding]; other site 759914003198 active site residues [active] 759914003199 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914003200 peptide binding site [polypeptide binding]; other site 759914003201 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 759914003202 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 759914003203 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 759914003204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 759914003205 dimerization interface [polypeptide binding]; other site 759914003206 ATP binding site [chemical binding]; other site 759914003207 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 759914003208 dimerization interface [polypeptide binding]; other site 759914003209 ATP binding site [chemical binding]; other site 759914003210 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 759914003211 putative active site [active] 759914003212 catalytic triad [active] 759914003213 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 759914003214 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759914003215 active site 759914003216 nucleotide binding site [chemical binding]; other site 759914003217 HIGH motif; other site 759914003218 KMSKS motif; other site 759914003219 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 759914003220 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 759914003221 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 759914003222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759914003223 NAD(P) binding site [chemical binding]; other site 759914003224 active site 759914003225 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 759914003226 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 759914003227 NAD binding site [chemical binding]; other site 759914003228 putative substrate binding site 2 [chemical binding]; other site 759914003229 putative substrate binding site 1 [chemical binding]; other site 759914003230 active site 759914003231 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 759914003232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759914003233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759914003234 putative substrate translocation pore; other site 759914003235 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 759914003236 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 759914003237 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 759914003238 NeuB family; Region: NeuB; pfam03102 759914003239 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 759914003240 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 759914003241 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 759914003242 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 759914003243 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 759914003244 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914003245 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759914003246 peptide binding site [polypeptide binding]; other site 759914003247 intracellular protease, PfpI family; Region: PfpI; TIGR01382 759914003248 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 759914003249 proposed catalytic triad [active] 759914003250 conserved cys residue [active] 759914003251 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 759914003252 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 759914003253 active site 759914003254 substrate binding site [chemical binding]; other site 759914003255 metal binding site [ion binding]; metal-binding site 759914003256 Leucine rich repeat; Region: LRR_8; pfam13855 759914003257 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 759914003258 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759914003259 RNA binding surface [nucleotide binding]; other site 759914003260 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 759914003261 active site 759914003262 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 759914003263 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 759914003264 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759914003265 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759914003266 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759914003267 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759914003268 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759914003269 Surface antigen; Region: Bac_surface_Ag; pfam01103 759914003270 Family of unknown function (DUF490); Region: DUF490; pfam04357 759914003271 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 759914003272 substrate binding site; other site 759914003273 dimer interface; other site 759914003274 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914003275 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 759914003276 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 759914003277 Peptidase family M28; Region: Peptidase_M28; pfam04389 759914003278 metal binding site [ion binding]; metal-binding site 759914003279 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 759914003280 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 759914003281 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_3; cd08770 759914003282 SxDxEG motif; other site 759914003283 putative active site [active] 759914003284 putative metal binding site [ion binding]; other site 759914003285 CHAT domain; Region: CHAT; cl17868 759914003286 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 759914003287 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 759914003288 amidase catalytic site [active] 759914003289 Zn binding residues [ion binding]; other site 759914003290 substrate binding site [chemical binding]; other site 759914003291 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 759914003292 homodimer interface [polypeptide binding]; other site 759914003293 active site 759914003294 SAM binding site [chemical binding]; other site 759914003295 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 759914003296 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759914003297 Zn2+ binding site [ion binding]; other site 759914003298 Mg2+ binding site [ion binding]; other site 759914003299 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003300 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003301 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914003302 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914003303 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003304 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914003305 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003306 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914003307 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003308 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759914003309 EamA-like transporter family; Region: EamA; cl17759 759914003310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914003311 TPR motif; other site 759914003312 binding surface 759914003313 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 759914003314 active site 759914003315 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 759914003316 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 759914003317 CoA binding domain; Region: CoA_binding; smart00881 759914003318 NAD-dependent deacetylase; Provisional; Region: PRK00481 759914003319 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 759914003320 NAD+ binding site [chemical binding]; other site 759914003321 substrate binding site [chemical binding]; other site 759914003322 Zn binding site [ion binding]; other site 759914003323 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 759914003324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 759914003325 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 759914003326 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 759914003327 catalytic triad [active] 759914003328 conserved cis-peptide bond; other site 759914003329 Peptidase M30; Region: Peptidase_M30; pfam10460 759914003330 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 759914003331 Peptidase family U32; Region: Peptidase_U32; pfam01136 759914003332 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 759914003333 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 759914003334 active site 759914003335 putative DNA-binding cleft [nucleotide binding]; other site 759914003336 dimer interface [polypeptide binding]; other site 759914003337 hypothetical protein; Validated; Region: PRK00110 759914003338 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 759914003339 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 759914003340 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 759914003341 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 759914003342 dimerization interface [polypeptide binding]; other site 759914003343 putative ATP binding site [chemical binding]; other site 759914003344 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 759914003345 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 759914003346 active site 759914003347 substrate binding site [chemical binding]; other site 759914003348 cosubstrate binding site; other site 759914003349 catalytic site [active] 759914003350 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 759914003351 Predicted chitinase [General function prediction only]; Region: COG3179 759914003352 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 759914003353 DNA methylase; Region: N6_N4_Mtase; cl17433 759914003354 DNA methylase; Region: N6_N4_Mtase; pfam01555 759914003355 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759914003356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 759914003357 DNA binding residues [nucleotide binding] 759914003358 dimerization interface [polypeptide binding]; other site 759914003359 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 759914003360 Predicted methyltransferases [General function prediction only]; Region: COG0313 759914003361 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 759914003362 putative SAM binding site [chemical binding]; other site 759914003363 putative homodimer interface [polypeptide binding]; other site 759914003364 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 759914003365 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003366 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914003367 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003368 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914003369 RecX family; Region: RecX; cl00936 759914003370 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 759914003371 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 759914003372 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 759914003373 active site residue [active] 759914003374 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 759914003375 putative homodimer interface [polypeptide binding]; other site 759914003376 putative homotetramer interface [polypeptide binding]; other site 759914003377 putative allosteric switch controlling residues; other site 759914003378 putative metal binding site [ion binding]; other site 759914003379 putative homodimer-homodimer interface [polypeptide binding]; other site 759914003380 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 759914003381 GDP-Fucose binding site [chemical binding]; other site 759914003382 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 759914003383 GDP-Fucose binding site [chemical binding]; other site 759914003384 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 759914003385 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 759914003386 motif 1; other site 759914003387 active site 759914003388 motif 2; other site 759914003389 motif 3; other site 759914003390 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 759914003391 HEAT repeats; Region: HEAT_2; pfam13646 759914003392 HEAT repeats; Region: HEAT_2; pfam13646 759914003393 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 759914003394 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 759914003395 ATP-grasp domain; Region: ATP-grasp_4; cl17255 759914003396 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 759914003397 metal binding site 2 [ion binding]; metal-binding site 759914003398 putative DNA binding helix; other site 759914003399 metal binding site 1 [ion binding]; metal-binding site 759914003400 dimer interface [polypeptide binding]; other site 759914003401 structural Zn2+ binding site [ion binding]; other site 759914003402 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 759914003403 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 759914003404 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 759914003405 homodimer interface [polypeptide binding]; other site 759914003406 NADP binding site [chemical binding]; other site 759914003407 substrate binding site [chemical binding]; other site 759914003408 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 759914003409 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 759914003410 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 759914003411 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 759914003412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914003413 S-adenosylmethionine binding site [chemical binding]; other site 759914003414 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 759914003415 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 759914003416 active site 759914003417 TPR repeat; Region: TPR_11; pfam13414 759914003418 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 759914003419 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 759914003420 Part of AAA domain; Region: AAA_19; pfam13245 759914003421 Family description; Region: UvrD_C_2; pfam13538 759914003422 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 759914003423 CoenzymeA binding site [chemical binding]; other site 759914003424 subunit interaction site [polypeptide binding]; other site 759914003425 PHB binding site; other site 759914003426 putative glycosyl transferase; Provisional; Region: PRK10073 759914003427 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 759914003428 active site 759914003429 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 759914003430 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 759914003431 active site 759914003432 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 759914003433 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 759914003434 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 759914003435 G1 box; other site 759914003436 GTP/Mg2+ binding site [chemical binding]; other site 759914003437 Switch I region; other site 759914003438 G2 box; other site 759914003439 G3 box; other site 759914003440 Switch II region; other site 759914003441 G4 box; other site 759914003442 G5 box; other site 759914003443 Nucleoside recognition; Region: Gate; pfam07670 759914003444 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 759914003445 Nucleoside recognition; Region: Gate; pfam07670 759914003446 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 759914003447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914003448 binding surface 759914003449 TPR motif; other site 759914003450 TPR repeat; Region: TPR_11; pfam13414 759914003451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914003452 binding surface 759914003453 TPR motif; other site 759914003454 TPR repeat; Region: TPR_11; pfam13414 759914003455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914003456 binding surface 759914003457 TPR motif; other site 759914003458 TPR repeat; Region: TPR_11; pfam13414 759914003459 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 759914003460 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 759914003461 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 759914003462 active site 759914003463 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 759914003464 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 759914003465 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 759914003466 Protein export membrane protein; Region: SecD_SecF; cl14618 759914003467 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 759914003468 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 759914003469 HlyD family secretion protein; Region: HlyD_3; pfam13437 759914003470 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 759914003471 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 759914003472 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 759914003473 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 759914003474 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 759914003475 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 759914003476 Fijivirus 64 kDa capsid protein; Region: Fiji_64_capsid; pfam05880 759914003477 H+ Antiporter protein; Region: 2A0121; TIGR00900 759914003478 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 759914003479 fumarate hydratase; Provisional; Region: PRK06246 759914003480 Fumarase C-terminus; Region: Fumerase_C; cl00795 759914003481 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 759914003482 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 759914003483 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 759914003484 alanine racemase; Reviewed; Region: alr; PRK00053 759914003485 active site 759914003486 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759914003487 dimer interface [polypeptide binding]; other site 759914003488 substrate binding site [chemical binding]; other site 759914003489 catalytic residues [active] 759914003490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 759914003491 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914003492 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914003493 dimer interface [polypeptide binding]; other site 759914003494 putative CheW interface [polypeptide binding]; other site 759914003495 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 759914003496 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 759914003497 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 759914003498 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 759914003499 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 759914003500 hinge; other site 759914003501 active site 759914003502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 759914003503 FeS/SAM binding site; other site 759914003504 trigger factor; Region: tig; TIGR00115 759914003505 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 759914003506 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 759914003507 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 759914003508 oligomer interface [polypeptide binding]; other site 759914003509 active site residues [active] 759914003510 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 759914003511 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 759914003512 active site 759914003513 metal binding site [ion binding]; metal-binding site 759914003514 PhoH-like protein; Region: PhoH; pfam02562 759914003515 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 759914003516 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 759914003517 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759914003518 Zn2+ binding site [ion binding]; other site 759914003519 Mg2+ binding site [ion binding]; other site 759914003520 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 759914003521 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 759914003522 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 759914003523 Transporter associated domain; Region: CorC_HlyC; smart01091 759914003524 amidophosphoribosyltransferase; Provisional; Region: PRK05793 759914003525 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 759914003526 active site 759914003527 tetramer interface [polypeptide binding]; other site 759914003528 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759914003529 active site 759914003530 signal recognition particle protein; Provisional; Region: PRK10867 759914003531 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 759914003532 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 759914003533 P loop; other site 759914003534 GTP binding site [chemical binding]; other site 759914003535 Signal peptide binding domain; Region: SRP_SPB; pfam02978 759914003536 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 759914003537 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 759914003538 RimM N-terminal domain; Region: RimM; pfam01782 759914003539 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 759914003540 active site 759914003541 HslU subunit interaction site [polypeptide binding]; other site 759914003542 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 759914003543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914003544 Walker A motif; other site 759914003545 ATP binding site [chemical binding]; other site 759914003546 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 759914003547 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 759914003548 Hemerythrin; Region: Hemerythrin; cd12107 759914003549 Fe binding site [ion binding]; other site 759914003550 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 759914003551 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 759914003552 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 759914003553 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 759914003554 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759914003555 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759914003556 substrate binding pocket [chemical binding]; other site 759914003557 membrane-bound complex binding site; other site 759914003558 hinge residues; other site 759914003559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759914003560 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759914003561 substrate binding pocket [chemical binding]; other site 759914003562 membrane-bound complex binding site; other site 759914003563 hinge residues; other site 759914003564 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 759914003565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914003566 dimer interface [polypeptide binding]; other site 759914003567 conserved gate region; other site 759914003568 putative PBP binding loops; other site 759914003569 ABC-ATPase subunit interface; other site 759914003570 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 759914003571 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 759914003572 Walker A/P-loop; other site 759914003573 ATP binding site [chemical binding]; other site 759914003574 Q-loop/lid; other site 759914003575 ABC transporter signature motif; other site 759914003576 Walker B; other site 759914003577 D-loop; other site 759914003578 H-loop/switch region; other site 759914003579 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 759914003580 active site 759914003581 putative catalytic site [active] 759914003582 phosphate binding site A [ion binding]; other site 759914003583 DNA binding site [nucleotide binding] 759914003584 metal binding site A [ion binding]; metal-binding site 759914003585 putative AP binding site [nucleotide binding]; other site 759914003586 putative metal binding site B [ion binding]; other site 759914003587 phosphate binding site B [ion binding]; other site 759914003588 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 759914003589 anti sigma factor interaction site; other site 759914003590 regulatory phosphorylation site [posttranslational modification]; other site 759914003591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914003592 binding surface 759914003593 TPR motif; other site 759914003594 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 759914003595 selenophosphate synthetase; Provisional; Region: PRK00943 759914003596 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 759914003597 dimerization interface [polypeptide binding]; other site 759914003598 putative ATP binding site [chemical binding]; other site 759914003599 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914003600 glutamate dehydrogenase; Provisional; Region: PRK09414 759914003601 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 759914003602 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 759914003603 NAD(P) binding site [chemical binding]; other site 759914003604 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759914003605 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759914003606 Walker A/P-loop; other site 759914003607 ATP binding site [chemical binding]; other site 759914003608 Q-loop/lid; other site 759914003609 ABC transporter signature motif; other site 759914003610 Walker B; other site 759914003611 D-loop; other site 759914003612 H-loop/switch region; other site 759914003613 hypothetical protein; Provisional; Region: PRK01346 759914003614 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 759914003615 Sterol carrier protein domain; Region: SCP2_2; pfam13530 759914003616 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 759914003617 MutS domain I; Region: MutS_I; pfam01624 759914003618 MutS domain II; Region: MutS_II; pfam05188 759914003619 MutS domain III; Region: MutS_III; pfam05192 759914003620 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 759914003621 Walker A/P-loop; other site 759914003622 ATP binding site [chemical binding]; other site 759914003623 Q-loop/lid; other site 759914003624 ABC transporter signature motif; other site 759914003625 Walker B; other site 759914003626 D-loop; other site 759914003627 H-loop/switch region; other site 759914003628 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 759914003629 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 759914003630 Catalytic site [active] 759914003631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759914003632 Coenzyme A binding pocket [chemical binding]; other site 759914003633 adenylosuccinate lyase; Provisional; Region: PRK07492 759914003634 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 759914003635 tetramer interface [polypeptide binding]; other site 759914003636 active site 759914003637 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 759914003638 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 759914003639 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 759914003640 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 759914003641 tetramer interface [polypeptide binding]; other site 759914003642 catalytic Zn binding site [ion binding]; other site 759914003643 NADP binding site [chemical binding]; other site 759914003644 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 759914003645 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 759914003646 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 759914003647 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 759914003648 Part of AAA domain; Region: AAA_19; pfam13245 759914003649 Family description; Region: UvrD_C_2; pfam13538 759914003650 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 759914003651 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 759914003652 dimer interface [polypeptide binding]; other site 759914003653 active site 759914003654 CoA binding pocket [chemical binding]; other site 759914003655 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 759914003656 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 759914003657 Ligand binding site; other site 759914003658 Putative Catalytic site; other site 759914003659 DXD motif; other site 759914003660 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 759914003661 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 759914003662 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 759914003663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759914003664 active site 759914003665 phosphorylation site [posttranslational modification] 759914003666 intermolecular recognition site; other site 759914003667 CheB methylesterase; Region: CheB_methylest; pfam01339 759914003668 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 759914003669 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 759914003670 putative active site [active] 759914003671 catalytic triad [active] 759914003672 putative dimer interface [polypeptide binding]; other site 759914003673 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914003674 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914003675 dimer interface [polypeptide binding]; other site 759914003676 putative CheW interface [polypeptide binding]; other site 759914003677 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 759914003678 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 759914003679 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 759914003680 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 759914003681 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 759914003682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914003683 S-adenosylmethionine binding site [chemical binding]; other site 759914003684 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 759914003685 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 759914003686 Cell division protein ZapA; Region: ZapA; pfam05164 759914003687 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 759914003688 flagellin; Provisional; Region: PRK12804 759914003689 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 759914003690 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 759914003691 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 759914003692 active site 759914003693 Zn binding site [ion binding]; other site 759914003694 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 759914003695 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 759914003696 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 759914003697 peroxiredoxin; Region: AhpC; TIGR03137 759914003698 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 759914003699 dimer interface [polypeptide binding]; other site 759914003700 decamer (pentamer of dimers) interface [polypeptide binding]; other site 759914003701 catalytic triad [active] 759914003702 peroxidatic and resolving cysteines [active] 759914003703 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 759914003704 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 759914003705 purine monophosphate binding site [chemical binding]; other site 759914003706 dimer interface [polypeptide binding]; other site 759914003707 putative catalytic residues [active] 759914003708 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 759914003709 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 759914003710 Predicted ATPases [General function prediction only]; Region: COG1106 759914003711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914003712 Walker A/P-loop; other site 759914003713 ATP binding site [chemical binding]; other site 759914003714 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 759914003715 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 759914003716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759914003717 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 759914003718 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 759914003719 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759914003720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914003721 homodimer interface [polypeptide binding]; other site 759914003722 catalytic residue [active] 759914003723 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 759914003724 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 759914003725 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 759914003726 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 759914003727 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 759914003728 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 759914003729 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003730 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 759914003731 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 759914003732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759914003733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759914003734 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 759914003735 dimerization interface [polypeptide binding]; other site 759914003736 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 759914003737 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 759914003738 trimer interface [polypeptide binding]; other site 759914003739 active site 759914003740 substrate binding site [chemical binding]; other site 759914003741 CoA binding site [chemical binding]; other site 759914003742 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 759914003743 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 759914003744 putative active site [active] 759914003745 PhoH-like protein; Region: PhoH; pfam02562 759914003746 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 759914003747 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 759914003748 active site 759914003749 NTP binding site [chemical binding]; other site 759914003750 metal binding triad [ion binding]; metal-binding site 759914003751 antibiotic binding site [chemical binding]; other site 759914003752 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 759914003753 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 759914003754 active site 759914003755 catalytic residue [active] 759914003756 dimer interface [polypeptide binding]; other site 759914003757 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 759914003758 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 759914003759 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 759914003760 shikimate binding site; other site 759914003761 NAD(P) binding site [chemical binding]; other site 759914003762 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 759914003763 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 759914003764 NAD(P) binding site [chemical binding]; other site 759914003765 homodimer interface [polypeptide binding]; other site 759914003766 substrate binding site [chemical binding]; other site 759914003767 active site 759914003768 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 759914003769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914003770 motif II; other site 759914003771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759914003772 dimer interface [polypeptide binding]; other site 759914003773 phosphorylation site [posttranslational modification] 759914003774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759914003775 ATP binding site [chemical binding]; other site 759914003776 Mg2+ binding site [ion binding]; other site 759914003777 G-X-G motif; other site 759914003778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 759914003779 active site 759914003780 phosphorylation site [posttranslational modification] 759914003781 intermolecular recognition site; other site 759914003782 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 759914003783 Na2 binding site [ion binding]; other site 759914003784 putative substrate binding site 1 [chemical binding]; other site 759914003785 Na binding site 1 [ion binding]; other site 759914003786 putative substrate binding site 2 [chemical binding]; other site 759914003787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914003788 binding surface 759914003789 TPR motif; other site 759914003790 TPR repeat; Region: TPR_11; pfam13414 759914003791 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914003792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914003793 binding surface 759914003794 TPR motif; other site 759914003795 TPR repeat; Region: TPR_11; pfam13414 759914003796 TPR repeat; Region: TPR_11; pfam13414 759914003797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914003798 binding surface 759914003799 TPR motif; other site 759914003800 TPR repeat; Region: TPR_11; pfam13414 759914003801 TPR repeat; Region: TPR_11; pfam13414 759914003802 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 759914003803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 759914003804 Mg2+ binding site [ion binding]; other site 759914003805 G-X-G motif; other site 759914003806 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 759914003807 active site 759914003808 Uncharacterized conserved protein [Function unknown]; Region: COG1543 759914003809 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 759914003810 active site 759914003811 substrate binding site [chemical binding]; other site 759914003812 catalytic site [active] 759914003813 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 759914003814 potential protein location (hypothetical protein BP951000_1386 [Brachyspira pilosicoli 95/1000]) that overlaps RNA (tRNA-L) 759914003815 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 759914003816 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 759914003817 metal ion-dependent adhesion site (MIDAS); other site 759914003818 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 759914003819 Predicted membrane protein [Function unknown]; Region: COG2510 759914003820 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 759914003821 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 759914003822 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 759914003823 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 759914003824 FtsH Extracellular; Region: FtsH_ext; pfam06480 759914003825 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 759914003826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914003827 Walker A motif; other site 759914003828 ATP binding site [chemical binding]; other site 759914003829 Walker B motif; other site 759914003830 arginine finger; other site 759914003831 Peptidase family M41; Region: Peptidase_M41; pfam01434 759914003832 NlpC/P60 family; Region: NLPC_P60; cl17555 759914003833 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 759914003834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 759914003835 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 759914003836 recombination factor protein RarA; Reviewed; Region: PRK13342 759914003837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914003838 Walker A motif; other site 759914003839 ATP binding site [chemical binding]; other site 759914003840 Walker B motif; other site 759914003841 arginine finger; other site 759914003842 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 759914003843 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 759914003844 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 759914003845 Peptidase family M50; Region: Peptidase_M50; pfam02163 759914003846 active site 759914003847 putative substrate binding region [chemical binding]; other site 759914003848 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 759914003849 YtxH-like protein; Region: YtxH; pfam12732 759914003850 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 759914003851 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 759914003852 inhibitor-cofactor binding pocket; inhibition site 759914003853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914003854 catalytic residue [active] 759914003855 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 759914003856 Predicted amidohydrolase [General function prediction only]; Region: COG0388 759914003857 active site 759914003858 catalytic triad [active] 759914003859 dimer interface [polypeptide binding]; other site 759914003860 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 759914003861 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 759914003862 Na2 binding site [ion binding]; other site 759914003863 putative substrate binding site 1 [chemical binding]; other site 759914003864 Na binding site 1 [ion binding]; other site 759914003865 putative substrate binding site 2 [chemical binding]; other site 759914003866 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 759914003867 MarR family; Region: MarR_2; pfam12802 759914003868 Flagellin N-methylase; Region: FliB; pfam03692 759914003869 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 759914003870 Radical SAM superfamily; Region: Radical_SAM; pfam04055 759914003871 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 759914003872 nudix motif; other site 759914003873 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 759914003874 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 759914003875 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 759914003876 catalytic motif [active] 759914003877 Zn binding site [ion binding]; other site 759914003878 RibD C-terminal domain; Region: RibD_C; cl17279 759914003879 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 759914003880 Lumazine binding domain; Region: Lum_binding; pfam00677 759914003881 Lumazine binding domain; Region: Lum_binding; pfam00677 759914003882 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 759914003883 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 759914003884 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 759914003885 dimerization interface [polypeptide binding]; other site 759914003886 active site 759914003887 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 759914003888 homopentamer interface [polypeptide binding]; other site 759914003889 active site 759914003890 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 759914003891 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 759914003892 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 759914003893 beta-galactosidase; Region: BGL; TIGR03356 759914003894 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 759914003895 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 759914003896 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 759914003897 Peptidase family U32; Region: Peptidase_U32; pfam01136 759914003898 Collagenase; Region: DUF3656; pfam12392 759914003899 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 759914003900 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003901 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914003902 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003903 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914003904 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 759914003905 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003906 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914003907 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 759914003908 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 759914003909 Protein of unknown function (DUF511); Region: DUF511; cl01114 759914003910 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003911 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914003912 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003913 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914003914 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914003915 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914003916 Phage terminase large subunit; Region: Terminase_3; cl12054 759914003917 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 759914003918 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 759914003919 TPR repeat; Region: TPR_11; pfam13414 759914003920 TPR repeat; Region: TPR_11; pfam13414 759914003921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914003922 binding surface 759914003923 TPR motif; other site 759914003924 TPR repeat; Region: TPR_11; pfam13414 759914003925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914003926 binding surface 759914003927 TPR motif; other site 759914003928 TPR repeat; Region: TPR_11; pfam13414 759914003929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914003930 binding surface 759914003931 TPR motif; other site 759914003932 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 759914003933 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 759914003934 dimer interface [polypeptide binding]; other site 759914003935 anticodon binding site; other site 759914003936 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 759914003937 homodimer interface [polypeptide binding]; other site 759914003938 motif 1; other site 759914003939 active site 759914003940 motif 2; other site 759914003941 GAD domain; Region: GAD; pfam02938 759914003942 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 759914003943 active site 759914003944 motif 3; other site 759914003945 Protein of unknown function (DUF819); Region: DUF819; cl02317 759914003946 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 759914003947 putative active site; other site 759914003948 putative metal binding residues [ion binding]; other site 759914003949 signature motif; other site 759914003950 putative triphosphate binding site [ion binding]; other site 759914003951 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 759914003952 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 759914003953 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 759914003954 metal ion-dependent adhesion site (MIDAS); other site 759914003955 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 759914003956 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 759914003957 putative metal binding site [ion binding]; other site 759914003958 RIP metalloprotease RseP; Region: TIGR00054 759914003959 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 759914003960 active site 759914003961 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 759914003962 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 759914003963 protein binding site [polypeptide binding]; other site 759914003964 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 759914003965 putative substrate binding region [chemical binding]; other site 759914003966 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 759914003967 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759914003968 active site 759914003969 DNA binding site [nucleotide binding] 759914003970 Int/Topo IB signature motif; other site 759914003971 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 759914003972 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 759914003973 catalytic residue [active] 759914003974 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 759914003975 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759914003976 DNA binding residues [nucleotide binding] 759914003977 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 759914003978 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 759914003979 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 759914003980 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 759914003981 oligomerization interface [polypeptide binding]; other site 759914003982 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 759914003983 Phage capsid family; Region: Phage_capsid; pfam05065 759914003984 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 759914003985 Phage portal protein; Region: Phage_portal; pfam04860 759914003986 Phage-related protein [Function unknown]; Region: COG4695 759914003987 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 759914003988 DNA methylase; Region: N6_N4_Mtase; pfam01555 759914003989 Phage terminase, small subunit; Region: Terminase_4; pfam05119 759914003990 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 759914003991 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 759914003992 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 759914003993 active site 759914003994 catalytic residues [active] 759914003995 DNA binding site [nucleotide binding] 759914003996 Int/Topo IB signature motif; other site 759914003997 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 759914003998 active site 759914003999 hypothetical protein; Validated; Region: PRK08116 759914004000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914004001 Walker A motif; other site 759914004002 ATP binding site [chemical binding]; other site 759914004003 Walker B motif; other site 759914004004 arginine finger; other site 759914004005 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 759914004006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 759914004007 active site 759914004008 phosphorylation site [posttranslational modification] 759914004009 intermolecular recognition site; other site 759914004010 dimerization interface [polypeptide binding]; other site 759914004011 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 759914004012 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 759914004013 metal binding site [ion binding]; metal-binding site 759914004014 active site 759914004015 I-site; other site 759914004016 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 759914004017 ligand binding site [chemical binding]; other site 759914004018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759914004019 active site 759914004020 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 759914004021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914004022 Walker A motif; other site 759914004023 ATP binding site [chemical binding]; other site 759914004024 Walker B motif; other site 759914004025 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 759914004026 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 759914004027 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 759914004028 TPR repeat; Region: TPR_11; pfam13414 759914004029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914004030 binding surface 759914004031 TPR motif; other site 759914004032 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 759914004033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914004034 dimer interface [polypeptide binding]; other site 759914004035 conserved gate region; other site 759914004036 putative PBP binding loops; other site 759914004037 ABC-ATPase subunit interface; other site 759914004038 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 759914004039 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 759914004040 Walker A/P-loop; other site 759914004041 ATP binding site [chemical binding]; other site 759914004042 Q-loop/lid; other site 759914004043 ABC transporter signature motif; other site 759914004044 Walker B; other site 759914004045 D-loop; other site 759914004046 H-loop/switch region; other site 759914004047 Ferredoxin [Energy production and conversion]; Region: COG1146 759914004048 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 759914004049 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 759914004050 dimer interface [polypeptide binding]; other site 759914004051 PYR/PP interface [polypeptide binding]; other site 759914004052 TPP binding site [chemical binding]; other site 759914004053 substrate binding site [chemical binding]; other site 759914004054 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 759914004055 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 759914004056 TPP-binding site [chemical binding]; other site 759914004057 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 759914004058 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 759914004059 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 759914004060 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 759914004061 dimer interface [polypeptide binding]; other site 759914004062 active site 759914004063 glycine-pyridoxal phosphate binding site [chemical binding]; other site 759914004064 folate binding site [chemical binding]; other site 759914004065 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 759914004066 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 759914004067 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 759914004068 active site 759914004069 trimer interface [polypeptide binding]; other site 759914004070 allosteric site; other site 759914004071 active site lid [active] 759914004072 hexamer (dimer of trimers) interface [polypeptide binding]; other site 759914004073 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 759914004074 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 759914004075 Protein export membrane protein; Region: SecD_SecF; cl14618 759914004076 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 759914004077 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 759914004078 Preprotein translocase subunit; Region: YajC; pfam02699 759914004079 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 759914004080 Ligand binding site; other site 759914004081 Putative Catalytic site; other site 759914004082 DXD motif; other site 759914004083 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 759914004084 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 759914004085 NADP binding site [chemical binding]; other site 759914004086 active site 759914004087 putative substrate binding site [chemical binding]; other site 759914004088 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 759914004089 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 759914004090 NADP-binding site; other site 759914004091 homotetramer interface [polypeptide binding]; other site 759914004092 substrate binding site [chemical binding]; other site 759914004093 homodimer interface [polypeptide binding]; other site 759914004094 active site 759914004095 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 759914004096 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914004097 hypothetical protein; Provisional; Region: PRK07208 759914004098 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759914004099 putative acyltransferase; Provisional; Region: PRK05790 759914004100 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 759914004101 dimer interface [polypeptide binding]; other site 759914004102 active site 759914004103 DNA methylase; Region: N6_N4_Mtase; cl17433 759914004104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914004105 S-adenosylmethionine binding site [chemical binding]; other site 759914004106 DNA methylase; Region: N6_N4_Mtase; cl17433 759914004107 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759914004108 active site 759914004109 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 759914004110 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 759914004111 dimer interface [polypeptide binding]; other site 759914004112 active site 759914004113 CoA binding pocket [chemical binding]; other site 759914004114 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 759914004115 putative active site [active] 759914004116 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 759914004117 Uncharacterized conserved protein [Function unknown]; Region: COG1633 759914004118 Uncharacterized conserved protein [Function unknown]; Region: COG3461 759914004119 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 759914004120 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 759914004121 putative active site pocket [active] 759914004122 cleavage site 759914004123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 759914004124 active site 759914004125 intermolecular recognition site; other site 759914004126 dimerization interface [polypeptide binding]; other site 759914004127 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 759914004128 dimer interface [polypeptide binding]; other site 759914004129 substrate binding site [chemical binding]; other site 759914004130 ATP binding site [chemical binding]; other site 759914004131 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 759914004132 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 759914004133 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 759914004134 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 759914004135 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 759914004136 putative homodimer interface [polypeptide binding]; other site 759914004137 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 759914004138 heterodimer interface [polypeptide binding]; other site 759914004139 homodimer interface [polypeptide binding]; other site 759914004140 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 759914004141 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 759914004142 23S rRNA interface [nucleotide binding]; other site 759914004143 L7/L12 interface [polypeptide binding]; other site 759914004144 putative thiostrepton binding site; other site 759914004145 L25 interface [polypeptide binding]; other site 759914004146 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 759914004147 mRNA/rRNA interface [nucleotide binding]; other site 759914004148 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 759914004149 23S rRNA interface [nucleotide binding]; other site 759914004150 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 759914004151 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 759914004152 core dimer interface [polypeptide binding]; other site 759914004153 peripheral dimer interface [polypeptide binding]; other site 759914004154 L10 interface [polypeptide binding]; other site 759914004155 L11 interface [polypeptide binding]; other site 759914004156 putative EF-Tu interaction site [polypeptide binding]; other site 759914004157 putative EF-G interaction site [polypeptide binding]; other site 759914004158 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 759914004159 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 759914004160 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 759914004161 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 759914004162 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 759914004163 RPB10 interaction site [polypeptide binding]; other site 759914004164 RPB1 interaction site [polypeptide binding]; other site 759914004165 RPB11 interaction site [polypeptide binding]; other site 759914004166 RPB3 interaction site [polypeptide binding]; other site 759914004167 RPB12 interaction site [polypeptide binding]; other site 759914004168 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 759914004169 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 759914004170 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 759914004171 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 759914004172 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 759914004173 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 759914004174 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 759914004175 cleft; other site 759914004176 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 759914004177 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 759914004178 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 759914004179 DNA binding site [nucleotide binding] 759914004180 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 759914004181 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 759914004182 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 759914004183 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 759914004184 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 759914004185 tetramer interface [polypeptide binding]; other site 759914004186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914004187 catalytic residue [active] 759914004188 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 759914004189 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 759914004190 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759914004191 Zn2+ binding site [ion binding]; other site 759914004192 Mg2+ binding site [ion binding]; other site 759914004193 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 759914004194 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 759914004195 potential protein location (conserved hypothetical protein [Brachyspira pilosicoli 95/1000]) that overlaps RNA (16S ribosomal RNA) 759914004196 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 759914004197 dimer interface [polypeptide binding]; other site 759914004198 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 759914004199 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 759914004200 substrate binding site [chemical binding]; other site 759914004201 dimer interface [polypeptide binding]; other site 759914004202 ATP binding site [chemical binding]; other site 759914004203 AbgT putative transporter family; Region: ABG_transport; cl17431 759914004204 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 759914004205 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 759914004206 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 759914004207 active site 759914004208 tetramer interface [polypeptide binding]; other site 759914004209 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759914004210 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759914004211 DNA binding site [nucleotide binding] 759914004212 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759914004213 dimerization interface [polypeptide binding]; other site 759914004214 ligand binding site [chemical binding]; other site 759914004215 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 759914004216 SmpB-tmRNA interface; other site 759914004217 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 759914004218 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 759914004219 Protein export membrane protein; Region: SecD_SecF; cl14618 759914004220 EamA-like transporter family; Region: EamA; pfam00892 759914004221 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 759914004222 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 759914004223 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 759914004224 trimer interface [polypeptide binding]; other site 759914004225 active site 759914004226 UDP-GlcNAc binding site [chemical binding]; other site 759914004227 lipid binding site [chemical binding]; lipid-binding site 759914004228 Domain of unknown function (DUF305); Region: DUF305; pfam03713 759914004229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914004230 binding surface 759914004231 TPR motif; other site 759914004232 Restriction endonuclease; Region: Mrr_cat; pfam04471 759914004233 Thymidine kinase; Region: TK; pfam00265 759914004234 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 759914004235 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 759914004236 SurA N-terminal domain; Region: SurA_N; pfam09312 759914004237 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 759914004238 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 759914004239 Protein of unknown function (DUF464); Region: DUF464; pfam04327 759914004240 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 759914004241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 759914004242 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 759914004243 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 759914004244 Ligand Binding Site [chemical binding]; other site 759914004245 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 759914004246 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 759914004247 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 759914004248 Hpr binding site; other site 759914004249 active site 759914004250 homohexamer subunit interaction site [polypeptide binding]; other site 759914004251 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 759914004252 active site 759914004253 phosphorylation site [posttranslational modification] 759914004254 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 759914004255 30S subunit binding site; other site 759914004256 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 759914004257 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 759914004258 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 759914004259 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 759914004260 Na2 binding site [ion binding]; other site 759914004261 putative substrate binding site 1 [chemical binding]; other site 759914004262 Na binding site 1 [ion binding]; other site 759914004263 putative substrate binding site 2 [chemical binding]; other site 759914004264 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 759914004265 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914004266 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914004267 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914004268 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 759914004269 Fe-S cluster binding site [ion binding]; other site 759914004270 active site 759914004271 Uncharacterized conserved protein [Function unknown]; Region: COG1912 759914004272 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 759914004273 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 759914004274 intersubunit interface [polypeptide binding]; other site 759914004275 active site 759914004276 zinc binding site [ion binding]; other site 759914004277 Na+ binding site [ion binding]; other site 759914004278 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 759914004279 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 759914004280 metal binding site [ion binding]; metal-binding site 759914004281 dimer interface [polypeptide binding]; other site 759914004282 OPT oligopeptide transporter protein; Region: OPT; cl14607 759914004283 putative oligopeptide transporter, OPT family; Region: TIGR00733 759914004284 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 759914004285 active site 759914004286 dimer interface [polypeptide binding]; other site 759914004287 metal binding site [ion binding]; metal-binding site 759914004288 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 759914004289 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 759914004290 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 759914004291 Nuclease-related domain; Region: NERD; pfam08378 759914004292 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 759914004293 heat shock protein 90; Provisional; Region: PRK05218 759914004294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759914004295 ATP binding site [chemical binding]; other site 759914004296 Mg2+ binding site [ion binding]; other site 759914004297 G-X-G motif; other site 759914004298 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759914004299 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914004300 peptide binding site [polypeptide binding]; other site 759914004301 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 759914004302 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759914004303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759914004304 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 759914004305 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 759914004306 anti sigma factor interaction site; other site 759914004307 regulatory phosphorylation site [posttranslational modification]; other site 759914004308 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 759914004309 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 759914004310 active site 759914004311 Riboflavin kinase; Region: Flavokinase; smart00904 759914004312 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 759914004313 16S/18S rRNA binding site [nucleotide binding]; other site 759914004314 S13e-L30e interaction site [polypeptide binding]; other site 759914004315 25S rRNA binding site [nucleotide binding]; other site 759914004316 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 759914004317 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 759914004318 RNase E interface [polypeptide binding]; other site 759914004319 trimer interface [polypeptide binding]; other site 759914004320 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 759914004321 RNase E interface [polypeptide binding]; other site 759914004322 trimer interface [polypeptide binding]; other site 759914004323 active site 759914004324 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 759914004325 putative nucleic acid binding region [nucleotide binding]; other site 759914004326 G-X-X-G motif; other site 759914004327 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 759914004328 RNA binding site [nucleotide binding]; other site 759914004329 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 759914004330 dimerization domain swap beta strand [polypeptide binding]; other site 759914004331 regulatory protein interface [polypeptide binding]; other site 759914004332 active site 759914004333 regulatory phosphorylation site [posttranslational modification]; other site 759914004334 HTH domain; Region: HTH_11; pfam08279 759914004335 Mga helix-turn-helix domain; Region: Mga; pfam05043 759914004336 PRD domain; Region: PRD; pfam00874 759914004337 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 759914004338 active site 759914004339 P-loop; other site 759914004340 phosphorylation site [posttranslational modification] 759914004341 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 759914004342 active site 759914004343 phosphorylation site [posttranslational modification] 759914004344 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 759914004345 active site 759914004346 Uncharacterized conserved protein [Function unknown]; Region: COG3589 759914004347 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 759914004348 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 759914004349 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 759914004350 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 759914004351 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 759914004352 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 759914004353 beta-galactosidase; Region: BGL; TIGR03356 759914004354 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 759914004355 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 759914004356 NAD binding site [chemical binding]; other site 759914004357 sugar binding site [chemical binding]; other site 759914004358 divalent metal binding site [ion binding]; other site 759914004359 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759914004360 dimer interface [polypeptide binding]; other site 759914004361 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 759914004362 methionine cluster; other site 759914004363 active site 759914004364 phosphorylation site [posttranslational modification] 759914004365 metal binding site [ion binding]; metal-binding site 759914004366 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 759914004367 active site 759914004368 substrate binding site [chemical binding]; other site 759914004369 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 759914004370 FMN binding site [chemical binding]; other site 759914004371 putative catalytic residues [active] 759914004372 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 759914004373 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 759914004374 catalytic residues [active] 759914004375 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 759914004376 Uncharacterized conserved protein [Function unknown]; Region: COG0062 759914004377 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 759914004378 putative substrate binding site [chemical binding]; other site 759914004379 putative ATP binding site [chemical binding]; other site 759914004380 flagellar motor switch protein; Validated; Region: PRK08119 759914004381 flagellar motor switch protein FliN; Region: fliN; TIGR02480 759914004382 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 759914004383 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 759914004384 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 759914004385 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 759914004386 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 759914004387 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759914004388 active site 759914004389 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 759914004390 SLBB domain; Region: SLBB; pfam10531 759914004391 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 759914004392 Divergent AAA domain; Region: AAA_4; pfam04326 759914004393 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 759914004394 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759914004395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759914004396 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 759914004397 NusA N-terminal domain; Region: NusA_N; pfam08529 759914004398 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 759914004399 RNA binding site [nucleotide binding]; other site 759914004400 homodimer interface [polypeptide binding]; other site 759914004401 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 759914004402 G-X-X-G motif; other site 759914004403 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 759914004404 G-X-X-G motif; other site 759914004405 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 759914004406 Methyltransferase domain; Region: Methyltransf_23; pfam13489 759914004407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914004408 S-adenosylmethionine binding site [chemical binding]; other site 759914004409 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 759914004410 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 759914004411 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 759914004412 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 759914004413 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 759914004414 Catalytic site [active] 759914004415 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 759914004416 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 759914004417 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914004418 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 759914004419 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 759914004420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914004421 Walker A/P-loop; other site 759914004422 ATP binding site [chemical binding]; other site 759914004423 Q-loop/lid; other site 759914004424 ABC transporter signature motif; other site 759914004425 Walker B; other site 759914004426 D-loop; other site 759914004427 H-loop/switch region; other site 759914004428 TOBE domain; Region: TOBE_2; pfam08402 759914004429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914004430 dimer interface [polypeptide binding]; other site 759914004431 conserved gate region; other site 759914004432 putative PBP binding loops; other site 759914004433 ABC-ATPase subunit interface; other site 759914004434 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 759914004435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914004436 dimer interface [polypeptide binding]; other site 759914004437 conserved gate region; other site 759914004438 putative PBP binding loops; other site 759914004439 ABC-ATPase subunit interface; other site 759914004440 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 759914004441 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 759914004442 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 759914004443 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 759914004444 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 759914004445 active site 759914004446 putative substrate binding pocket [chemical binding]; other site 759914004447 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 759914004448 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 759914004449 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 759914004450 NAD binding site [chemical binding]; other site 759914004451 Phe binding site; other site 759914004452 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 759914004453 dimer interface [polypeptide binding]; other site 759914004454 motif 1; other site 759914004455 active site 759914004456 motif 2; other site 759914004457 motif 3; other site 759914004458 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 759914004459 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 759914004460 putative catalytic cysteine [active] 759914004461 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 759914004462 putative active site [active] 759914004463 metal binding site [ion binding]; metal-binding site 759914004464 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 759914004465 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 759914004466 Ligand binding site; other site 759914004467 Putative Catalytic site; other site 759914004468 DXD motif; other site 759914004469 enolase; Provisional; Region: eno; PRK00077 759914004470 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 759914004471 dimer interface [polypeptide binding]; other site 759914004472 metal binding site [ion binding]; metal-binding site 759914004473 substrate binding pocket [chemical binding]; other site 759914004474 Hemerythrin; Region: Hemerythrin; cd12107 759914004475 Fe binding site [ion binding]; other site 759914004476 Hemerythrin; Region: Hemerythrin; cd12107 759914004477 Fe binding site [ion binding]; other site 759914004478 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 759914004479 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 759914004480 HIRAN domain; Region: HIRAN; cl07418 759914004481 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 759914004482 DJ-1 family protein; Region: not_thiJ; TIGR01383 759914004483 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 759914004484 conserved cys residue [active] 759914004485 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 759914004486 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 759914004487 active site 759914004488 Substrate binding site; other site 759914004489 Mg++ binding site; other site 759914004490 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 759914004491 putative trimer interface [polypeptide binding]; other site 759914004492 putative CoA binding site [chemical binding]; other site 759914004493 spiro-SPASM protein; Region: spiroSPASM; TIGR04321 759914004494 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 759914004495 peptide chain release factor 1; Validated; Region: prfA; PRK00591 759914004496 This domain is found in peptide chain release factors; Region: PCRF; smart00937 759914004497 RF-1 domain; Region: RF-1; pfam00472 759914004498 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914004499 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 759914004500 DHH family; Region: DHH; pfam01368 759914004501 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 759914004502 DHHA1 domain; Region: DHHA1; pfam02272 759914004503 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 759914004504 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 759914004505 Potassium binding sites [ion binding]; other site 759914004506 Cesium cation binding sites [ion binding]; other site 759914004507 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 759914004508 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 759914004509 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 759914004510 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 759914004511 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 759914004512 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 759914004513 Protein of unknown function (DUF1636); Region: DUF1636; cl17843 759914004514 Uncharacterized conserved protein [Function unknown]; Region: COG0432 759914004515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914004516 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 759914004517 motif II; other site 759914004518 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 759914004519 phosphopentomutase; Provisional; Region: PRK05362 759914004520 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 759914004521 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 759914004522 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 759914004523 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759914004524 FtsX-like permease family; Region: FtsX; pfam02687 759914004525 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 759914004526 FtsX-like permease family; Region: FtsX; pfam02687 759914004527 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759914004528 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759914004529 Walker A/P-loop; other site 759914004530 ATP binding site [chemical binding]; other site 759914004531 Q-loop/lid; other site 759914004532 ABC transporter signature motif; other site 759914004533 Walker B; other site 759914004534 D-loop; other site 759914004535 H-loop/switch region; other site 759914004536 Flavoprotein; Region: Flavoprotein; pfam02441 759914004537 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 759914004538 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 759914004539 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 759914004540 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 759914004541 Substrate binding site; other site 759914004542 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 759914004543 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 759914004544 active site 759914004545 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 759914004546 Peptidase family M23; Region: Peptidase_M23; pfam01551 759914004547 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 759914004548 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 759914004549 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 759914004550 FAD binding pocket [chemical binding]; other site 759914004551 FAD binding motif [chemical binding]; other site 759914004552 phosphate binding motif [ion binding]; other site 759914004553 beta-alpha-beta structure motif; other site 759914004554 NAD binding pocket [chemical binding]; other site 759914004555 Iron coordination center [ion binding]; other site 759914004556 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 759914004557 ADP binding site [chemical binding]; other site 759914004558 phosphagen binding site; other site 759914004559 substrate specificity loop; other site 759914004560 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 759914004561 UvrB/uvrC motif; Region: UVR; pfam02151 759914004562 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 759914004563 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 759914004564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914004565 FeS/SAM binding site; other site 759914004566 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 759914004567 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 759914004568 active site 759914004569 (T/H)XGH motif; other site 759914004570 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 759914004571 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 759914004572 S4 RNA-binding domain; Region: S4; smart00363 759914004573 RNA binding surface [nucleotide binding]; other site 759914004574 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 759914004575 active site 759914004576 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 759914004577 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 759914004578 ligand binding site [chemical binding]; other site 759914004579 calcium binding site [ion binding]; other site 759914004580 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 759914004581 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 759914004582 Walker A/P-loop; other site 759914004583 ATP binding site [chemical binding]; other site 759914004584 Q-loop/lid; other site 759914004585 ABC transporter signature motif; other site 759914004586 Walker B; other site 759914004587 D-loop; other site 759914004588 H-loop/switch region; other site 759914004589 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 759914004590 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 759914004591 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759914004592 TM-ABC transporter signature motif; other site 759914004593 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 759914004594 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 759914004595 methionine sulfoxide reductase B; Provisional; Region: PRK05508 759914004596 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 759914004597 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 759914004598 homodimer interface [polypeptide binding]; other site 759914004599 substrate-cofactor binding pocket; other site 759914004600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914004601 catalytic residue [active] 759914004602 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 759914004603 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 759914004604 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 759914004605 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 759914004606 Malic enzyme, N-terminal domain; Region: malic; pfam00390 759914004607 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 759914004608 putative NAD(P) binding site [chemical binding]; other site 759914004609 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759914004610 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914004611 peptide binding site [polypeptide binding]; other site 759914004612 Chromate transporter; Region: Chromate_transp; pfam02417 759914004613 Chromate transporter; Region: Chromate_transp; pfam02417 759914004614 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759914004615 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 759914004616 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759914004617 active site 759914004618 Methyltransferase domain; Region: Methyltransf_24; pfam13578 759914004619 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759914004620 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 759914004621 nucleotide binding site [chemical binding]; other site 759914004622 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 759914004623 active site 759914004624 metal binding site [ion binding]; metal-binding site 759914004625 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 759914004626 C-terminal peptidase (prc); Region: prc; TIGR00225 759914004627 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 759914004628 protein binding site [polypeptide binding]; other site 759914004629 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 759914004630 Catalytic dyad [active] 759914004631 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 759914004632 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 759914004633 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 759914004634 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 759914004635 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 759914004636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759914004637 active site 759914004638 phosphorylation site [posttranslational modification] 759914004639 intermolecular recognition site; other site 759914004640 dimerization interface [polypeptide binding]; other site 759914004641 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 759914004642 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 759914004643 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 759914004644 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 759914004645 metal binding site [ion binding]; metal-binding site 759914004646 dimer interface [polypeptide binding]; other site 759914004647 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 759914004648 diiron binding motif [ion binding]; other site 759914004649 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 759914004650 YcxB-like protein; Region: YcxB; pfam14317 759914004651 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 759914004652 Uncharacterized conserved protein [Function unknown]; Region: COG2461 759914004653 Family of unknown function (DUF438); Region: DUF438; pfam04282 759914004654 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 759914004655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914004656 TPR motif; other site 759914004657 binding surface 759914004658 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914004659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914004660 binding surface 759914004661 TPR motif; other site 759914004662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914004663 binding surface 759914004664 TPR repeat; Region: TPR_11; pfam13414 759914004665 TPR motif; other site 759914004666 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 759914004667 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 759914004668 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 759914004669 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 759914004670 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 759914004671 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 759914004672 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 759914004673 Ligand Binding Site [chemical binding]; other site 759914004674 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 759914004675 peptidase T; Region: peptidase-T; TIGR01882 759914004676 metal binding site [ion binding]; metal-binding site 759914004677 dimer interface [polypeptide binding]; other site 759914004678 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 759914004679 active site 759914004680 thiamine monophosphate kinase; Provisional; Region: PRK05731 759914004681 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 759914004682 ATP binding site [chemical binding]; other site 759914004683 dimerization interface [polypeptide binding]; other site 759914004684 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 759914004685 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 759914004686 GatB domain; Region: GatB_Yqey; smart00845 759914004687 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 759914004688 Mrr N-terminal domain; Region: Mrr_N; pfam14338 759914004689 Restriction endonuclease; Region: Mrr_cat; pfam04471 759914004690 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 759914004691 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759914004692 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 759914004693 active site 759914004694 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 759914004695 Restriction endonuclease; Region: Mrr_cat; pfam04471 759914004696 Restriction endonuclease; Region: Mrr_cat; pfam04471 759914004697 HAMP domain; Region: HAMP; pfam00672 759914004698 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914004699 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914004700 dimer interface [polypeptide binding]; other site 759914004701 putative CheW interface [polypeptide binding]; other site 759914004702 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 759914004703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914004704 S-adenosylmethionine binding site [chemical binding]; other site 759914004705 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 759914004706 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 759914004707 active site 759914004708 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 759914004709 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 759914004710 Tetramer interface [polypeptide binding]; other site 759914004711 active site 759914004712 FMN-binding site [chemical binding]; other site 759914004713 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 759914004714 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 759914004715 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 759914004716 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 759914004717 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759914004718 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 759914004719 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 759914004720 ligand binding site [chemical binding]; other site 759914004721 calcium binding site [ion binding]; other site 759914004722 LexA repressor; Validated; Region: PRK00215 759914004723 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 759914004724 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 759914004725 Catalytic site [active] 759914004726 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 759914004727 Ferritin-like domain; Region: Ferritin; pfam00210 759914004728 ferroxidase diiron center [ion binding]; other site 759914004729 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 759914004730 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 759914004731 Walker A/P-loop; other site 759914004732 ATP binding site [chemical binding]; other site 759914004733 Q-loop/lid; other site 759914004734 ABC transporter signature motif; other site 759914004735 Walker B; other site 759914004736 D-loop; other site 759914004737 H-loop/switch region; other site 759914004738 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 759914004739 ZIP Zinc transporter; Region: Zip; pfam02535 759914004740 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 759914004741 nucleotide binding site/active site [active] 759914004742 HIT family signature motif; other site 759914004743 catalytic residue [active] 759914004744 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 759914004745 active site 759914004746 Uncharacterized N-terminal domain of the transcription elongation factor GreA [Function unknown]; Region: COG1747 759914004747 TPR repeat; Region: TPR_11; pfam13414 759914004748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914004749 binding surface 759914004750 TPR motif; other site 759914004751 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 759914004752 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 759914004753 Helix-turn-helix domain; Region: HTH_25; pfam13413 759914004754 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 759914004755 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 759914004756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914004757 FeS/SAM binding site; other site 759914004758 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 759914004759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914004760 Walker A motif; other site 759914004761 ATP binding site [chemical binding]; other site 759914004762 Walker B motif; other site 759914004763 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 759914004764 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 759914004765 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759914004766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759914004767 DNA binding residues [nucleotide binding] 759914004768 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 759914004769 Clp amino terminal domain; Region: Clp_N; pfam02861 759914004770 Clp amino terminal domain; Region: Clp_N; pfam02861 759914004771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914004772 Walker A motif; other site 759914004773 ATP binding site [chemical binding]; other site 759914004774 Walker B motif; other site 759914004775 arginine finger; other site 759914004776 UvrB/uvrC motif; Region: UVR; pfam02151 759914004777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914004778 Walker A motif; other site 759914004779 ATP binding site [chemical binding]; other site 759914004780 Walker B motif; other site 759914004781 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 759914004782 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914004783 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 759914004784 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 759914004785 intersubunit interface [polypeptide binding]; other site 759914004786 active site 759914004787 catalytic residue [active] 759914004788 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 759914004789 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 759914004790 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 759914004791 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 759914004792 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 759914004793 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 759914004794 ligand binding site [chemical binding]; other site 759914004795 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 759914004796 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 759914004797 ligand binding site [chemical binding]; other site 759914004798 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 759914004799 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 759914004800 Walker A/P-loop; other site 759914004801 ATP binding site [chemical binding]; other site 759914004802 Q-loop/lid; other site 759914004803 ABC transporter signature motif; other site 759914004804 Walker B; other site 759914004805 D-loop; other site 759914004806 H-loop/switch region; other site 759914004807 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 759914004808 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759914004809 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 759914004810 TM-ABC transporter signature motif; other site 759914004811 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759914004812 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 759914004813 TM-ABC transporter signature motif; other site 759914004814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914004815 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 759914004816 active site 759914004817 motif I; other site 759914004818 motif II; other site 759914004819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914004820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914004821 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 759914004822 active site 759914004823 motif I; other site 759914004824 motif II; other site 759914004825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914004826 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 759914004827 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 759914004828 TspO/MBR family; Region: TspO_MBR; pfam03073 759914004829 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 759914004830 substrate binding pocket [chemical binding]; other site 759914004831 substrate-Mg2+ binding site; other site 759914004832 aspartate-rich region 1; other site 759914004833 aspartate-rich region 2; other site 759914004834 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 759914004835 homotrimer interaction site [polypeptide binding]; other site 759914004836 zinc binding site [ion binding]; other site 759914004837 CDP-binding sites; other site 759914004838 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 759914004839 Outer membrane efflux protein; Region: OEP; pfam02321 759914004840 Outer membrane efflux protein; Region: OEP; pfam02321 759914004841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759914004842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759914004843 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759914004844 active site 759914004845 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 759914004846 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 759914004847 putative tRNA-binding site [nucleotide binding]; other site 759914004848 B3/4 domain; Region: B3_4; pfam03483 759914004849 tRNA synthetase B5 domain; Region: B5; pfam03484 759914004850 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 759914004851 dimer interface [polypeptide binding]; other site 759914004852 motif 1; other site 759914004853 motif 3; other site 759914004854 motif 2; other site 759914004855 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 759914004856 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 759914004857 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 759914004858 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 759914004859 dimer interface [polypeptide binding]; other site 759914004860 motif 1; other site 759914004861 active site 759914004862 motif 2; other site 759914004863 motif 3; other site 759914004864 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 759914004865 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 759914004866 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 759914004867 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 759914004868 N-glycosylase/DNA lyase; Provisional; Region: PRK01229 759914004869 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 759914004870 minor groove reading motif; other site 759914004871 helix-hairpin-helix signature motif; other site 759914004872 active site 759914004873 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 759914004874 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 759914004875 active site 759914004876 metal binding site [ion binding]; metal-binding site 759914004877 P-loop containing region of AAA domain; Region: AAA_29; cl17516 759914004878 AAA domain; Region: AAA_21; pfam13304 759914004879 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 759914004880 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914004881 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 759914004882 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 759914004883 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 759914004884 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 759914004885 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 759914004886 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759914004887 active site 759914004888 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 759914004889 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 759914004890 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 759914004891 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 759914004892 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 759914004893 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 759914004894 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 759914004895 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 759914004896 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 759914004897 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914004898 RelB antitoxin; Region: RelB; cl01171 759914004899 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 759914004900 Protein of unknown function (DUF2806); Region: DUF2806; pfam10987 759914004901 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 759914004902 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759914004903 active site 759914004904 HIGH motif; other site 759914004905 nucleotide binding site [chemical binding]; other site 759914004906 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 759914004907 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 759914004908 active site 759914004909 KMSKS motif; other site 759914004910 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 759914004911 tRNA binding surface [nucleotide binding]; other site 759914004912 anticodon binding site; other site 759914004913 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 759914004914 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 759914004915 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 759914004916 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914004917 dimer interface [polypeptide binding]; other site 759914004918 putative CheW interface [polypeptide binding]; other site 759914004919 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914004920 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 759914004921 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759914004922 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914004923 peptide binding site [polypeptide binding]; other site 759914004924 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 759914004925 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 759914004926 metal binding site [ion binding]; metal-binding site 759914004927 dimer interface [polypeptide binding]; other site 759914004928 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 759914004929 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 759914004930 catalytic triad [active] 759914004931 amino acid transporter; Region: 2A0306; TIGR00909 759914004932 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 759914004933 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759914004934 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759914004935 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 759914004936 glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265 759914004937 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 759914004938 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 759914004939 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 759914004940 dimer interface [polypeptide binding]; other site 759914004941 active site 759914004942 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 759914004943 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 759914004944 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 759914004945 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 759914004946 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 759914004947 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 759914004948 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 759914004949 iron-sulfur cluster [ion binding]; other site 759914004950 [2Fe-2S] cluster binding site [ion binding]; other site 759914004951 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 759914004952 hydrophobic ligand binding site; other site 759914004953 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 759914004954 GTP-binding protein YchF; Reviewed; Region: PRK09601 759914004955 YchF GTPase; Region: YchF; cd01900 759914004956 G1 box; other site 759914004957 GTP/Mg2+ binding site [chemical binding]; other site 759914004958 Switch I region; other site 759914004959 G2 box; other site 759914004960 Switch II region; other site 759914004961 G3 box; other site 759914004962 G4 box; other site 759914004963 G5 box; other site 759914004964 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 759914004965 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 759914004966 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 759914004967 Cl- selectivity filter; other site 759914004968 Cl- binding residues [ion binding]; other site 759914004969 pore gating glutamate residue; other site 759914004970 dimer interface [polypeptide binding]; other site 759914004971 H+/Cl- coupling transport residue; other site 759914004972 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 759914004973 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 759914004974 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 759914004975 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914004976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914004977 binding surface 759914004978 TPR motif; other site 759914004979 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914004980 Protein of unknown function (DUF721); Region: DUF721; pfam05258 759914004981 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 759914004982 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 759914004983 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 759914004984 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 759914004985 PhoU domain; Region: PhoU; pfam01895 759914004986 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914004987 dimer interface [polypeptide binding]; other site 759914004988 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 759914004989 putative CheW interface [polypeptide binding]; other site 759914004990 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 759914004991 phosphate binding site [ion binding]; other site 759914004992 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 759914004993 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 759914004994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759914004995 DNA-binding site [nucleotide binding]; DNA binding site 759914004996 UTRA domain; Region: UTRA; pfam07702 759914004997 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759914004998 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 759914004999 active site 759914005000 catalytic tetrad [active] 759914005001 DNA polymerase phi; Region: DNA_pol_phi; pfam04931 759914005002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005003 binding surface 759914005004 TPR motif; other site 759914005005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005006 TPR motif; other site 759914005007 binding surface 759914005008 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914005009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005010 binding surface 759914005011 TPR motif; other site 759914005012 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 759914005013 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 759914005014 gamma subunit interface [polypeptide binding]; other site 759914005015 epsilon subunit interface [polypeptide binding]; other site 759914005016 LBP interface [polypeptide binding]; other site 759914005017 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 759914005018 active site 759914005019 PilZ domain; Region: PilZ; pfam07238 759914005020 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 759914005021 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 759914005022 putative CheA interaction surface; other site 759914005023 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 759914005024 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 759914005025 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 759914005026 metal-binding site [ion binding] 759914005027 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 759914005028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914005029 motif II; other site 759914005030 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914005031 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914005032 dimer interface [polypeptide binding]; other site 759914005033 putative CheW interface [polypeptide binding]; other site 759914005034 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 759914005035 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 759914005036 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 759914005037 recombinase A; Provisional; Region: recA; PRK09354 759914005038 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 759914005039 hexamer interface [polypeptide binding]; other site 759914005040 Walker A motif; other site 759914005041 ATP binding site [chemical binding]; other site 759914005042 Walker B motif; other site 759914005043 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 759914005044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759914005045 Coenzyme A binding pocket [chemical binding]; other site 759914005046 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 759914005047 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 759914005048 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 759914005049 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 759914005050 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 759914005051 gamma-glutamyl kinase; Provisional; Region: PRK05429 759914005052 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 759914005053 nucleotide binding site [chemical binding]; other site 759914005054 homotetrameric interface [polypeptide binding]; other site 759914005055 putative phosphate binding site [ion binding]; other site 759914005056 putative allosteric binding site; other site 759914005057 PUA domain; Region: PUA; pfam01472 759914005058 electron transport complex RsxE subunit; Provisional; Region: PRK12405 759914005059 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 759914005060 Putative Fe-S cluster; Region: FeS; cl17515 759914005061 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 759914005062 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 759914005063 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 759914005064 Protein of unknown function DUF58; Region: DUF58; pfam01882 759914005065 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 759914005066 metal ion-dependent adhesion site (MIDAS); other site 759914005067 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 759914005068 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759914005069 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759914005070 Peptidase family M23; Region: Peptidase_M23; pfam01551 759914005071 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 759914005072 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 759914005073 putative active site [active] 759914005074 putative metal binding site [ion binding]; other site 759914005075 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914005076 peptide binding site [polypeptide binding]; other site 759914005077 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 759914005078 Predicted transcriptional regulators [Transcription]; Region: COG1733 759914005079 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 759914005080 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 759914005081 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 759914005082 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 759914005083 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914005084 motif II; other site 759914005085 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 759914005086 active site 759914005087 catalytic residues [active] 759914005088 metal binding site [ion binding]; metal-binding site 759914005089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759914005090 dimer interface [polypeptide binding]; other site 759914005091 phosphorylation site [posttranslational modification] 759914005092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759914005093 ATP binding site [chemical binding]; other site 759914005094 G-X-G motif; other site 759914005095 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 759914005096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759914005097 active site 759914005098 phosphorylation site [posttranslational modification] 759914005099 intermolecular recognition site; other site 759914005100 dimerization interface [polypeptide binding]; other site 759914005101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914005102 Walker A motif; other site 759914005103 ATP binding site [chemical binding]; other site 759914005104 Walker B motif; other site 759914005105 arginine finger; other site 759914005106 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 759914005107 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 759914005108 HPr interaction site; other site 759914005109 glycerol kinase (GK) interaction site [polypeptide binding]; other site 759914005110 active site 759914005111 phosphorylation site [posttranslational modification] 759914005112 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 759914005113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914005114 Walker A/P-loop; other site 759914005115 ATP binding site [chemical binding]; other site 759914005116 Q-loop/lid; other site 759914005117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914005118 ABC transporter signature motif; other site 759914005119 Walker B; other site 759914005120 D-loop; other site 759914005121 H-loop/switch region; other site 759914005122 Uncharacterized conserved protein [Function unknown]; Region: COG1359 759914005123 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 759914005124 putative active site [active] 759914005125 catalytic residue [active] 759914005126 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 759914005127 putative active site [active] 759914005128 catalytic residue [active] 759914005129 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 759914005130 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 759914005131 5S rRNA interface [nucleotide binding]; other site 759914005132 CTC domain interface [polypeptide binding]; other site 759914005133 L16 interface [polypeptide binding]; other site 759914005134 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 759914005135 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 759914005136 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759914005137 active site 759914005138 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 759914005139 homotrimer interaction site [polypeptide binding]; other site 759914005140 putative active site [active] 759914005141 Domain of unknown function (DUF368); Region: DUF368; pfam04018 759914005142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914005143 binding surface 759914005144 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914005145 TPR motif; other site 759914005146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005147 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 759914005148 TPR motif; other site 759914005149 binding surface 759914005150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759914005151 non-specific DNA binding site [nucleotide binding]; other site 759914005152 salt bridge; other site 759914005153 sequence-specific DNA binding site [nucleotide binding]; other site 759914005154 Bacitracin resistance protein BacA; Region: BacA; pfam02673 759914005155 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 759914005156 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 759914005157 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 759914005158 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 759914005159 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 759914005160 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 759914005161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759914005162 ATP binding site [chemical binding]; other site 759914005163 Mg2+ binding site [ion binding]; other site 759914005164 G-X-G motif; other site 759914005165 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 759914005166 ATP binding site [chemical binding]; other site 759914005167 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 759914005168 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 759914005169 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 759914005170 active site residue [active] 759914005171 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 759914005172 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 759914005173 active site 759914005174 HIGH motif; other site 759914005175 dimer interface [polypeptide binding]; other site 759914005176 KMSKS motif; other site 759914005177 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 759914005178 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005179 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005180 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005181 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005182 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914005183 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005184 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005185 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005186 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005187 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005188 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005189 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005190 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005191 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005192 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005193 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914005194 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005195 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914005196 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005197 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005198 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005199 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005200 FMN-binding domain; Region: FMN_bind; cl01081 759914005201 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 759914005202 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 759914005203 SLBB domain; Region: SLBB; pfam10531 759914005204 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 759914005205 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 759914005206 active site 759914005207 putative phosphate acyltransferase; Provisional; Region: PRK05331 759914005208 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 759914005209 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 759914005210 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 759914005211 G1 box; other site 759914005212 GTP/Mg2+ binding site [chemical binding]; other site 759914005213 Switch I region; other site 759914005214 G2 box; other site 759914005215 Switch II region; other site 759914005216 G3 box; other site 759914005217 G4 box; other site 759914005218 G5 box; other site 759914005219 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 759914005220 G1 box; other site 759914005221 GTP/Mg2+ binding site [chemical binding]; other site 759914005222 Switch I region; other site 759914005223 G2 box; other site 759914005224 G3 box; other site 759914005225 Switch II region; other site 759914005226 G4 box; other site 759914005227 G5 box; other site 759914005228 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 759914005229 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 759914005230 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 759914005231 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 759914005232 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 759914005233 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 759914005234 inhibitor-cofactor binding pocket; inhibition site 759914005235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914005236 catalytic residue [active] 759914005237 DNA polymerase III subunit beta; Validated; Region: PRK05643 759914005238 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 759914005239 putative DNA binding surface [nucleotide binding]; other site 759914005240 dimer interface [polypeptide binding]; other site 759914005241 beta-clamp/clamp loader binding surface; other site 759914005242 beta-clamp/translesion DNA polymerase binding surface; other site 759914005243 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 759914005244 classical (c) SDRs; Region: SDR_c; cd05233 759914005245 NAD(P) binding site [chemical binding]; other site 759914005246 active site 759914005247 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 759914005248 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 759914005249 Mg++ binding site [ion binding]; other site 759914005250 putative catalytic motif [active] 759914005251 putative substrate binding site [chemical binding]; other site 759914005252 thymidylate kinase; Validated; Region: tmk; PRK00698 759914005253 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 759914005254 TMP-binding site; other site 759914005255 ATP-binding site [chemical binding]; other site 759914005256 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 759914005257 DNA binding site [nucleotide binding] 759914005258 catalytic residue [active] 759914005259 H2TH interface [polypeptide binding]; other site 759914005260 putative catalytic residues [active] 759914005261 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 759914005262 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 759914005263 nucleophile elbow; other site 759914005264 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 759914005265 catalytic core [active] 759914005266 CobD/Cbib protein; Region: CobD_Cbib; cl00561 759914005267 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 759914005268 putative FMN binding site [chemical binding]; other site 759914005269 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 759914005270 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 759914005271 Walker A/P-loop; other site 759914005272 ATP binding site [chemical binding]; other site 759914005273 Q-loop/lid; other site 759914005274 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 759914005275 ABC transporter signature motif; other site 759914005276 Walker B; other site 759914005277 D-loop; other site 759914005278 H-loop/switch region; other site 759914005279 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 759914005280 ATP-NAD kinase; Region: NAD_kinase; pfam01513 759914005281 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 759914005282 MarR family; Region: MarR_2; cl17246 759914005283 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 759914005284 Predicted membrane protein [Function unknown]; Region: COG2364 759914005285 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 759914005286 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 759914005287 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 759914005288 active site 759914005289 catalytic residues [active] 759914005290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914005291 S-adenosylmethionine binding site [chemical binding]; other site 759914005292 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 759914005293 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914005294 FeS/SAM binding site; other site 759914005295 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 759914005296 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 759914005297 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 759914005298 B3/4 domain; Region: B3_4; pfam03483 759914005299 GTP-binding protein LepA; Provisional; Region: PRK05433 759914005300 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 759914005301 G1 box; other site 759914005302 putative GEF interaction site [polypeptide binding]; other site 759914005303 GTP/Mg2+ binding site [chemical binding]; other site 759914005304 Switch I region; other site 759914005305 G2 box; other site 759914005306 G3 box; other site 759914005307 Switch II region; other site 759914005308 G4 box; other site 759914005309 G5 box; other site 759914005310 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 759914005311 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 759914005312 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 759914005313 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 759914005314 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759914005315 ABC-ATPase subunit interface; other site 759914005316 dimer interface [polypeptide binding]; other site 759914005317 putative PBP binding regions; other site 759914005318 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 759914005319 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 759914005320 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 759914005321 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 759914005322 intersubunit interface [polypeptide binding]; other site 759914005323 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 759914005324 Rubredoxin [Energy production and conversion]; Region: COG1773 759914005325 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 759914005326 iron binding site [ion binding]; other site 759914005327 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 759914005328 active site 759914005329 LabA_like proteins; Region: LabA_like; cd06167 759914005330 putative metal binding site [ion binding]; other site 759914005331 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 759914005332 prephenate dehydrogenase; Validated; Region: PRK08507 759914005333 CTP synthetase; Validated; Region: pyrG; PRK05380 759914005334 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 759914005335 Catalytic site [active] 759914005336 active site 759914005337 UTP binding site [chemical binding]; other site 759914005338 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 759914005339 active site 759914005340 putative oxyanion hole; other site 759914005341 catalytic triad [active] 759914005342 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759914005343 Predicted solute binding protein [General function prediction only]; Region: COG3889 759914005344 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914005345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005346 binding surface 759914005347 TPR motif; other site 759914005348 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914005349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005350 binding surface 759914005351 TPR repeat; Region: TPR_11; pfam13414 759914005352 TPR motif; other site 759914005353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005354 binding surface 759914005355 TPR repeat; Region: TPR_11; pfam13414 759914005356 TPR motif; other site 759914005357 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914005358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005359 binding surface 759914005360 TPR motif; other site 759914005361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005362 TPR repeat; Region: TPR_11; pfam13414 759914005363 TPR motif; other site 759914005364 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 759914005365 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 759914005366 N-acetyl-D-glucosamine binding site [chemical binding]; other site 759914005367 catalytic residue [active] 759914005368 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 759914005369 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 759914005370 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 759914005371 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 759914005372 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 759914005373 active site 759914005374 dimer interface [polypeptide binding]; other site 759914005375 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 759914005376 dimer interface [polypeptide binding]; other site 759914005377 active site 759914005378 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 759914005379 trimer interface [polypeptide binding]; other site 759914005380 active site 759914005381 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 759914005382 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759914005383 RNA binding surface [nucleotide binding]; other site 759914005384 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 759914005385 active site 759914005386 FMN-binding domain; Region: FMN_bind; cl01081 759914005387 Competence protein; Region: Competence; pfam03772 759914005388 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759914005389 Transglycosylase; Region: Transgly; pfam00912 759914005390 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 759914005391 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 759914005392 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005393 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005394 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005395 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005396 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005397 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005398 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 759914005399 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 759914005400 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 759914005401 metal binding site [ion binding]; metal-binding site 759914005402 dimer interface [polypeptide binding]; other site 759914005403 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 759914005404 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 759914005405 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005406 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914005407 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005408 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005409 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005410 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914005411 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914005412 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914005413 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 759914005414 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 759914005415 putative active site [active] 759914005416 glycogen synthase; Provisional; Region: glgA; PRK00654 759914005417 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 759914005418 ADP-binding pocket [chemical binding]; other site 759914005419 homodimer interface [polypeptide binding]; other site 759914005420 intracellular protease, PfpI family; Region: PfpI; TIGR01382 759914005421 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 759914005422 conserved cys residue [active] 759914005423 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914005424 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 759914005425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 759914005426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759914005427 Coenzyme A binding pocket [chemical binding]; other site 759914005428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 759914005429 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 759914005430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914005431 FeS/SAM binding site; other site 759914005432 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 759914005433 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 759914005434 G1 box; other site 759914005435 GTP/Mg2+ binding site [chemical binding]; other site 759914005436 Switch I region; other site 759914005437 G2 box; other site 759914005438 Switch II region; other site 759914005439 G3 box; other site 759914005440 G4 box; other site 759914005441 G5 box; other site 759914005442 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 759914005443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914005444 FeS/SAM binding site; other site 759914005445 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 759914005446 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 759914005447 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759914005448 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759914005449 peptide binding site [polypeptide binding]; other site 759914005450 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 759914005451 active site 759914005452 substrate-binding site [chemical binding]; other site 759914005453 metal-binding site [ion binding] 759914005454 GTP binding site [chemical binding]; other site 759914005455 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 759914005456 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 759914005457 catalytic site [active] 759914005458 Asp-box motif; other site 759914005459 TPR repeat; Region: TPR_11; pfam13414 759914005460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005461 TPR motif; other site 759914005462 binding surface 759914005463 DNA protecting protein DprA; Region: dprA; TIGR00732 759914005464 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 759914005465 DNA topoisomerase I; Validated; Region: PRK05582 759914005466 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 759914005467 active site 759914005468 interdomain interaction site; other site 759914005469 putative metal-binding site [ion binding]; other site 759914005470 nucleotide binding site [chemical binding]; other site 759914005471 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 759914005472 domain I; other site 759914005473 DNA binding groove [nucleotide binding] 759914005474 phosphate binding site [ion binding]; other site 759914005475 domain II; other site 759914005476 domain III; other site 759914005477 nucleotide binding site [chemical binding]; other site 759914005478 catalytic site [active] 759914005479 domain IV; other site 759914005480 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 759914005481 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 759914005482 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 759914005483 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 759914005484 active site 759914005485 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 759914005486 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 759914005487 active site 759914005488 metal binding site [ion binding]; metal-binding site 759914005489 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 759914005490 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 759914005491 active site 759914005492 P-loop; other site 759914005493 phosphorylation site [posttranslational modification] 759914005494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 759914005495 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 759914005496 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759914005497 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 759914005498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759914005499 Mg2+ binding site [ion binding]; other site 759914005500 G-X-G motif; other site 759914005501 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 759914005502 anchoring element; other site 759914005503 dimer interface [polypeptide binding]; other site 759914005504 ATP binding site [chemical binding]; other site 759914005505 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 759914005506 active site 759914005507 putative metal-binding site [ion binding]; other site 759914005508 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 759914005509 Formaldehyde dehydrogenases; Region: FDH_like; cd05278 759914005510 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 759914005511 catalytic Zn binding site [ion binding]; other site 759914005512 NAD(P) binding site [chemical binding]; other site 759914005513 structural Zn binding site [ion binding]; other site 759914005514 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 759914005515 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 759914005516 GIY-YIG motif/motif A; other site 759914005517 active site 759914005518 catalytic site [active] 759914005519 putative DNA binding site [nucleotide binding]; other site 759914005520 metal binding site [ion binding]; metal-binding site 759914005521 UvrB/uvrC motif; Region: UVR; pfam02151 759914005522 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 759914005523 Alkylmercury lyase; Region: MerB; pfam03243 759914005524 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759914005525 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 759914005526 Walker A/P-loop; other site 759914005527 ATP binding site [chemical binding]; other site 759914005528 Q-loop/lid; other site 759914005529 ABC transporter signature motif; other site 759914005530 Walker B; other site 759914005531 D-loop; other site 759914005532 H-loop/switch region; other site 759914005533 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759914005534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914005535 dimer interface [polypeptide binding]; other site 759914005536 conserved gate region; other site 759914005537 putative PBP binding loops; other site 759914005538 ABC-ATPase subunit interface; other site 759914005539 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 759914005540 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 759914005541 Predicted permeases [General function prediction only]; Region: COG0701 759914005542 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 759914005543 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 759914005544 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 759914005545 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 759914005546 acyl-activating enzyme (AAE) consensus motif; other site 759914005547 putative AMP binding site [chemical binding]; other site 759914005548 putative active site [active] 759914005549 putative CoA binding site [chemical binding]; other site 759914005550 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 759914005551 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 759914005552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759914005553 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 759914005554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759914005555 DNA binding residues [nucleotide binding] 759914005556 DNA primase; Validated; Region: dnaG; PRK05667 759914005557 CHC2 zinc finger; Region: zf-CHC2; cl17510 759914005558 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 759914005559 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 759914005560 active site 759914005561 metal binding site [ion binding]; metal-binding site 759914005562 interdomain interaction site; other site 759914005563 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 759914005564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914005565 S-adenosylmethionine binding site [chemical binding]; other site 759914005566 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 759914005567 catalytic triad [active] 759914005568 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 759914005569 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 759914005570 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 759914005571 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 759914005572 Leucine rich repeat; Region: LRR_8; pfam13855 759914005573 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 759914005574 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 759914005575 putative acyl-acceptor binding pocket; other site 759914005576 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 759914005577 active site 759914005578 catalytic triad [active] 759914005579 oxyanion hole [active] 759914005580 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914005581 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 759914005582 excinuclease ABC subunit B; Provisional; Region: PRK05298 759914005583 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759914005584 ATP binding site [chemical binding]; other site 759914005585 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759914005586 nucleotide binding region [chemical binding]; other site 759914005587 ATP-binding site [chemical binding]; other site 759914005588 Ultra-violet resistance protein B; Region: UvrB; pfam12344 759914005589 UvrB/uvrC motif; Region: UVR; pfam02151 759914005590 MraW methylase family; Region: Methyltransf_5; cl17771 759914005591 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 759914005592 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 759914005593 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 759914005594 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759914005595 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759914005596 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 759914005597 dimer interface [polypeptide binding]; other site 759914005598 catalytic triad [active] 759914005599 peroxidatic and resolving cysteines [active] 759914005600 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 759914005601 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 759914005602 dimer interface [polypeptide binding]; other site 759914005603 catalytic residues [active] 759914005604 Serpulina hyodysenteriae variable surface protein; Region: Serpulina_VSP; pfam05540 759914005605 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 759914005606 AzlC protein; Region: AzlC; cl00570 759914005607 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 759914005608 Competence-damaged protein; Region: CinA; pfam02464 759914005609 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 759914005610 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 759914005611 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 759914005612 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 759914005613 FliG C-terminal domain; Region: FliG_C; pfam01706 759914005614 flagellar assembly protein H; Validated; Region: fliH; PRK06669 759914005615 Flagellar assembly protein FliH; Region: FliH; pfam02108 759914005616 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 759914005617 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 759914005618 Walker A motif/ATP binding site; other site 759914005619 Walker B motif; other site 759914005620 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 759914005621 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 759914005622 N-acetyl-D-glucosamine binding site [chemical binding]; other site 759914005623 catalytic residue [active] 759914005624 NHL repeat; Region: NHL; pfam01436 759914005625 Uncharacterized conserved protein [Function unknown]; Region: COG3391 759914005626 NHL repeat; Region: NHL; pfam01436 759914005627 Predicted permeases [General function prediction only]; Region: COG0795 759914005628 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 759914005629 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 759914005630 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 759914005631 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 759914005632 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 759914005633 oligomer interface [polypeptide binding]; other site 759914005634 tandem repeat interface [polypeptide binding]; other site 759914005635 active site residues [active] 759914005636 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 759914005637 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 759914005638 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 759914005639 Rubrerythrin [Energy production and conversion]; Region: COG1592 759914005640 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 759914005641 binuclear metal center [ion binding]; other site 759914005642 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 759914005643 iron binding site [ion binding]; other site 759914005644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 759914005645 Nucleoside recognition; Region: Gate; pfam07670 759914005646 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 759914005647 substrate binding site [chemical binding]; other site 759914005648 multimerization interface [polypeptide binding]; other site 759914005649 ATP binding site [chemical binding]; other site 759914005650 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 759914005651 ligand binding site [chemical binding]; other site 759914005652 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 759914005653 Clp amino terminal domain; Region: Clp_N; pfam02861 759914005654 Clp amino terminal domain; Region: Clp_N; pfam02861 759914005655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914005656 Walker A motif; other site 759914005657 ATP binding site [chemical binding]; other site 759914005658 Walker B motif; other site 759914005659 arginine finger; other site 759914005660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914005661 Walker A motif; other site 759914005662 ATP binding site [chemical binding]; other site 759914005663 Walker B motif; other site 759914005664 arginine finger; other site 759914005665 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 759914005666 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759914005667 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 759914005668 active site 759914005669 catalytic tetrad [active] 759914005670 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 759914005671 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 759914005672 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 759914005673 S-adenosylmethionine synthetase; Validated; Region: PRK05250 759914005674 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 759914005675 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 759914005676 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 759914005677 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759914005678 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 759914005679 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 759914005680 putative active site [active] 759914005681 putative metal binding site [ion binding]; other site 759914005682 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 759914005683 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 759914005684 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 759914005685 B12 binding site [chemical binding]; other site 759914005686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914005687 FeS/SAM binding site; other site 759914005688 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 759914005689 A new structural DNA glycosylase; Region: AlkD_like; cl11434 759914005690 active site 759914005691 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005692 TPR motif; other site 759914005693 TPR repeat; Region: TPR_11; pfam13414 759914005694 binding surface 759914005695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005696 binding surface 759914005697 TPR motif; other site 759914005698 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914005699 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914005700 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 759914005701 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 759914005702 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 759914005703 putative hydrolase; Validated; Region: PRK09248 759914005704 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 759914005705 active site 759914005706 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 759914005707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914005708 FeS/SAM binding site; other site 759914005709 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 759914005710 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 759914005711 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 759914005712 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 759914005713 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 759914005714 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 759914005715 active site 759914005716 metal binding site [ion binding]; metal-binding site 759914005717 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 759914005718 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 759914005719 Interdomain contacts; other site 759914005720 Cytokine receptor motif; other site 759914005721 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005722 binding surface 759914005723 TPR motif; other site 759914005724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005725 binding surface 759914005726 TPR motif; other site 759914005727 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759914005728 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 759914005729 binding surface 759914005730 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914005731 TPR motif; other site 759914005732 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 759914005733 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 759914005734 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 759914005735 ligand binding site [chemical binding]; other site 759914005736 flexible hinge region; other site 759914005737 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 759914005738 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 759914005739 ligand binding site [chemical binding]; other site 759914005740 flexible hinge region; other site 759914005741 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 759914005742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005743 binding surface 759914005744 TPR motif; other site 759914005745 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 759914005746 RNA/DNA hybrid binding site [nucleotide binding]; other site 759914005747 active site 759914005748 DHH family; Region: DHH; pfam01368 759914005749 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 759914005750 DHHA1 domain; Region: DHHA1; pfam02272 759914005751 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 759914005752 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 759914005753 putative CheA interaction surface; other site 759914005754 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 759914005755 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 759914005756 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 759914005757 Bifunctional nuclease; Region: DNase-RNase; pfam02577 759914005758 UvrB/uvrC motif; Region: UVR; pfam02151 759914005759 TPR repeat; Region: TPR_11; pfam13414 759914005760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914005761 binding surface 759914005762 TPR motif; other site 759914005763 Tetratricopeptide repeat; Region: TPR_12; pfam13424 759914005764 potential frameshift: common BLAST hit: gi|296125076|ref|YP_003632328.1| PfkB domain protein 759914005765 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 759914005766 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 759914005767 ATP binding site [chemical binding]; other site 759914005768 substrate binding site [chemical binding]; other site 759914005769 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 759914005770 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 759914005771 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 759914005772 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 759914005773 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 759914005774 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 759914005775 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 759914005776 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 759914005777 putative active site cavity [active] 759914005778 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 759914005779 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 759914005780 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 759914005781 active site turn [active] 759914005782 phosphorylation site [posttranslational modification] 759914005783 DNA gyrase subunit A; Validated; Region: PRK05560 759914005784 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 759914005785 CAP-like domain; other site 759914005786 active site 759914005787 primary dimer interface [polypeptide binding]; other site 759914005788 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759914005789 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759914005790 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759914005791 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759914005792 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 759914005793 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759914005794 active site 759914005795 DNA binding site [nucleotide binding] 759914005796 Int/Topo IB signature motif; other site 759914005797 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 759914005798 Domain of unknown function (DUF368); Region: DUF368; pfam04018 759914005799 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 759914005800 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 759914005801 putative active site [active] 759914005802 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 759914005803 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 759914005804 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 759914005805 active site 759914005806 HIGH motif; other site 759914005807 nucleotide binding site [chemical binding]; other site 759914005808 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 759914005809 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 759914005810 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759914005811 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759914005812 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 759914005813 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 759914005814 Protein of unknown function, DUF486; Region: DUF486; cl01236 759914005815 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 759914005816 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 759914005817 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 759914005818 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 759914005819 active site 759914005820 PHP Thumb interface [polypeptide binding]; other site 759914005821 metal binding site [ion binding]; metal-binding site 759914005822 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759914005823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914005824 dimer interface [polypeptide binding]; other site 759914005825 conserved gate region; other site 759914005826 putative PBP binding loops; other site 759914005827 ABC-ATPase subunit interface; other site 759914005828 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759914005829 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759914005830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914005831 putative PBP binding loops; other site 759914005832 dimer interface [polypeptide binding]; other site 759914005833 ABC-ATPase subunit interface; other site 759914005834 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 759914005835 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759914005836 Walker A/P-loop; other site 759914005837 ATP binding site [chemical binding]; other site 759914005838 Q-loop/lid; other site 759914005839 ABC transporter signature motif; other site 759914005840 Walker B; other site 759914005841 D-loop; other site 759914005842 H-loop/switch region; other site 759914005843 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759914005844 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 759914005845 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759914005846 Walker A/P-loop; other site 759914005847 ATP binding site [chemical binding]; other site 759914005848 Q-loop/lid; other site 759914005849 ABC transporter signature motif; other site 759914005850 Walker B; other site 759914005851 D-loop; other site 759914005852 H-loop/switch region; other site 759914005853 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759914005854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759914005855 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759914005856 Walker A motif; other site 759914005857 ATP binding site [chemical binding]; other site 759914005858 Walker B motif; other site 759914005859 arginine finger; other site 759914005860 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 759914005861 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 759914005862 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 759914005863 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 759914005864 4Fe-4S binding domain; Region: Fer4_6; pfam12837 759914005865 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 759914005866 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 759914005867 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 759914005868 ligand binding site [chemical binding]; other site 759914005869 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 759914005870 Predicted transcriptional regulator [Transcription]; Region: COG1959 759914005871 Transcriptional regulator; Region: Rrf2; pfam02082 759914005872 ferrochelatase; Reviewed; Region: hemH; PRK00035 759914005873 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 759914005874 C-terminal domain interface [polypeptide binding]; other site 759914005875 active site 759914005876 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 759914005877 active site 759914005878 N-terminal domain interface [polypeptide binding]; other site 759914005879 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 759914005880 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 759914005881 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 759914005882 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 759914005883 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 759914005884 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 759914005885 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 759914005886 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 759914005887 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 759914005888 active site 759914005889 dimer interface [polypeptide binding]; other site 759914005890 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 759914005891 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 759914005892 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 759914005893 GTP/Mg2+ binding site [chemical binding]; other site 759914005894 G4 box; other site 759914005895 trmE is a tRNA modification GTPase; Region: trmE; cd04164 759914005896 G1 box; other site 759914005897 G1 box; other site 759914005898 GTP/Mg2+ binding site [chemical binding]; other site 759914005899 Switch I region; other site 759914005900 Switch I region; other site 759914005901 G2 box; other site 759914005902 G2 box; other site 759914005903 Switch II region; other site 759914005904 G3 box; other site 759914005905 G4 box; other site 759914005906 G5 box; other site 759914005907 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 759914005908 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 759914005909 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759914005910 catalytic residue [active] 759914005911 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 759914005912 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 759914005913 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 759914005914 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 759914005915 active site 759914005916 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 759914005917 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 759914005918 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 759914005919 DNA repair protein RadA; Provisional; Region: PRK11823 759914005920 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 759914005921 Walker A motif; other site 759914005922 ATP binding site [chemical binding]; other site 759914005923 Walker B motif; other site 759914005924 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 759914005925 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 759914005926 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 759914005927 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 759914005928 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 759914005929 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 759914005930 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 759914005931 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 759914005932 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 759914005933 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 759914005934 L-aspartate oxidase; Provisional; Region: PRK06175 759914005935 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 759914005936 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 759914005937 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 759914005938 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 759914005939 Predicted permeases [General function prediction only]; Region: COG0730 759914005940 hypothetical protein; Provisional; Region: PRK10621 759914005941 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 759914005942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759914005943 Coenzyme A binding pocket [chemical binding]; other site 759914005944 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 759914005945 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 759914005946 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 759914005947 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 759914005948 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 759914005949 FHIPEP family; Region: FHIPEP; pfam00771 759914005950 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 759914005951 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 759914005952 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 759914005953 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 759914005954 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 759914005955 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 759914005956 P-loop; other site 759914005957 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 759914005958 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 759914005959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759914005960 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 759914005961 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759914005962 DNA binding residues [nucleotide binding] 759914005963 Protein of unknown function (DUF342); Region: DUF342; pfam03961 759914005964 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 759914005965 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 759914005966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914005967 motif II; other site 759914005968 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 759914005969 Recombination protein O N terminal; Region: RecO_N; pfam11967 759914005970 Recombination protein O C terminal; Region: RecO_C; pfam02565 759914005971 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 759914005972 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 759914005973 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 759914005974 Domain of unknown function DUF21; Region: DUF21; pfam01595 759914005975 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 759914005976 Transporter associated domain; Region: CorC_HlyC; smart01091 759914005977 thymidylate synthase; Reviewed; Region: thyA; PRK01827 759914005978 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 759914005979 dimerization interface [polypeptide binding]; other site 759914005980 active site 759914005981 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 759914005982 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 759914005983 folate binding site [chemical binding]; other site 759914005984 NADP+ binding site [chemical binding]; other site 759914005985 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 759914005986 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 759914005987 active site 759914005988 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 759914005989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914005990 active site 759914005991 motif I; other site 759914005992 motif II; other site 759914005993 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759914005994 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 759914005995 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 759914005996 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 759914005997 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 759914005998 NAD(P) binding site [chemical binding]; other site 759914005999 catalytic residues [active] 759914006000 Stage II sporulation protein; Region: SpoIID; pfam08486 759914006001 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 759914006002 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 759914006003 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 759914006004 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 759914006005 dimer interface [polypeptide binding]; other site 759914006006 motif 1; other site 759914006007 active site 759914006008 motif 2; other site 759914006009 motif 3; other site 759914006010 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 759914006011 anticodon binding site; other site 759914006012 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914006013 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914006014 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914006015 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914006016 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914006017 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914006018 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 759914006019 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 759914006020 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 759914006021 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 759914006022 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 759914006023 hinge; other site 759914006024 active site 759914006025 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 759914006026 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 759914006027 Ligand binding site; other site 759914006028 Putative Catalytic site; other site 759914006029 DXD motif; other site 759914006030 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 759914006031 dimer interface [polypeptide binding]; other site 759914006032 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 759914006033 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759914006034 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759914006035 DNA binding residues [nucleotide binding] 759914006036 Putative zinc-finger; Region: zf-HC2; pfam13490 759914006037 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 759914006038 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 759914006039 dimer interface [polypeptide binding]; other site 759914006040 ADP-ribose binding site [chemical binding]; other site 759914006041 active site 759914006042 nudix motif; other site 759914006043 metal binding site [ion binding]; metal-binding site 759914006044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759914006045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759914006046 dimer interface [polypeptide binding]; other site 759914006047 phosphorylation site [posttranslational modification] 759914006048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759914006049 ATP binding site [chemical binding]; other site 759914006050 Mg2+ binding site [ion binding]; other site 759914006051 G-X-G motif; other site 759914006052 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 759914006053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 759914006054 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 759914006055 Phosphotransferase enzyme family; Region: APH; pfam01636 759914006056 GMP synthase; Reviewed; Region: guaA; PRK00074 759914006057 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 759914006058 AMP/PPi binding site [chemical binding]; other site 759914006059 candidate oxyanion hole; other site 759914006060 catalytic triad [active] 759914006061 potential glutamine specificity residues [chemical binding]; other site 759914006062 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 759914006063 ATP Binding subdomain [chemical binding]; other site 759914006064 Ligand Binding sites [chemical binding]; other site 759914006065 Dimerization subdomain; other site 759914006066 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 759914006067 DNA methylase; Region: N6_N4_Mtase; cl17433 759914006068 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 759914006069 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 759914006070 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 759914006071 metal binding site [ion binding]; metal-binding site 759914006072 active site 759914006073 I-site; other site 759914006074 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 759914006075 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 759914006076 putative active site [active] 759914006077 metal binding site [ion binding]; metal-binding site 759914006078 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 759914006079 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 759914006080 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759914006081 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 759914006082 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759914006083 DNA binding residues [nucleotide binding] 759914006084 potential frameshift: common BLAST hit: gi|225619758|ref|YP_002721015.1| cytidylate kinase 759914006085 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 759914006086 active site 759914006087 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 759914006088 cytidylate kinase; Provisional; Region: cmk; PRK00023 759914006089 CMP-binding site; other site 759914006090 The sites determining sugar specificity; other site 759914006091 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 759914006092 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 759914006093 RNA binding site [nucleotide binding]; other site 759914006094 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 759914006095 RNA binding site [nucleotide binding]; other site 759914006096 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 759914006097 RNA binding site [nucleotide binding]; other site 759914006098 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 759914006099 RNA binding site [nucleotide binding]; other site 759914006100 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 759914006101 RNA binding site [nucleotide binding]; other site 759914006102 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 759914006103 RNA binding site [nucleotide binding]; other site 759914006104 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 759914006105 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 759914006106 intersubunit interface [polypeptide binding]; other site 759914006107 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759914006108 ABC-ATPase subunit interface; other site 759914006109 dimer interface [polypeptide binding]; other site 759914006110 putative PBP binding regions; other site 759914006111 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 759914006112 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 759914006113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914006114 Walker A/P-loop; other site 759914006115 ATP binding site [chemical binding]; other site 759914006116 Q-loop/lid; other site 759914006117 ABC transporter signature motif; other site 759914006118 Walker B; other site 759914006119 D-loop; other site 759914006120 H-loop/switch region; other site 759914006121 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 759914006122 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 759914006123 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 759914006124 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 759914006125 Walker A/P-loop; other site 759914006126 ATP binding site [chemical binding]; other site 759914006127 Q-loop/lid; other site 759914006128 ABC transporter signature motif; other site 759914006129 Walker B; other site 759914006130 D-loop; other site 759914006131 H-loop/switch region; other site 759914006132 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 759914006133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759914006134 dimer interface [polypeptide binding]; other site 759914006135 conserved gate region; other site 759914006136 ABC-ATPase subunit interface; other site 759914006137 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 759914006138 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759914006139 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 759914006140 NAD binding site [chemical binding]; other site 759914006141 dimer interface [polypeptide binding]; other site 759914006142 substrate binding site [chemical binding]; other site 759914006143 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 759914006144 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 759914006145 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 759914006146 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 759914006147 TM2 domain; Region: TM2; pfam05154 759914006148 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914006149 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914006150 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 759914006151 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 759914006152 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 759914006153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914006154 Walker A/P-loop; other site 759914006155 ATP binding site [chemical binding]; other site 759914006156 Q-loop/lid; other site 759914006157 ABC transporter signature motif; other site 759914006158 Walker B; other site 759914006159 D-loop; other site 759914006160 H-loop/switch region; other site 759914006161 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 759914006162 oligomerisation interface [polypeptide binding]; other site 759914006163 mobile loop; other site 759914006164 roof hairpin; other site 759914006165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759914006166 S-adenosylmethionine binding site [chemical binding]; other site 759914006167 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 759914006168 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 759914006169 active site residue [active] 759914006170 Cache domain; Region: Cache_1; pfam02743 759914006171 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914006172 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914006173 dimer interface [polypeptide binding]; other site 759914006174 putative CheW interface [polypeptide binding]; other site 759914006175 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 759914006176 Glycoprotease family; Region: Peptidase_M22; pfam00814 759914006177 Protein of unknown function (DUF327); Region: DUF327; pfam03885 759914006178 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 759914006179 Na2 binding site [ion binding]; other site 759914006180 putative substrate binding site 1 [chemical binding]; other site 759914006181 Na binding site 1 [ion binding]; other site 759914006182 putative substrate binding site 2 [chemical binding]; other site 759914006183 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759914006184 dimerization interface [polypeptide binding]; other site 759914006185 putative DNA binding site [nucleotide binding]; other site 759914006186 putative Zn2+ binding site [ion binding]; other site 759914006187 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 759914006188 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 759914006189 Soluble P-type ATPase [General function prediction only]; Region: COG4087 759914006190 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 759914006191 Mechanosensitive ion channel; Region: MS_channel; pfam00924 759914006192 Cache domain; Region: Cache_1; pfam02743 759914006193 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914006194 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914006195 dimer interface [polypeptide binding]; other site 759914006196 putative CheW interface [polypeptide binding]; other site 759914006197 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 759914006198 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 759914006199 ParB-like nuclease domain; Region: ParB; smart00470 759914006200 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 759914006201 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759914006202 P-loop; other site 759914006203 Magnesium ion binding site [ion binding]; other site 759914006204 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759914006205 Magnesium ion binding site [ion binding]; other site 759914006206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914006207 binding surface 759914006208 TPR motif; other site 759914006209 TPR repeat; Region: TPR_11; pfam13414 759914006210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914006211 TPR motif; other site 759914006212 binding surface 759914006213 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 759914006214 Peptidase family M23; Region: Peptidase_M23; pfam01551 759914006215 PQQ-like domain; Region: PQQ_2; pfam13360 759914006216 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 759914006217 Peptidase family M23; Region: Peptidase_M23; pfam01551 759914006218 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 759914006219 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 759914006220 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 759914006221 replicative DNA helicase; Region: DnaB; TIGR00665 759914006222 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 759914006223 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 759914006224 Walker A motif; other site 759914006225 ATP binding site [chemical binding]; other site 759914006226 Walker B motif; other site 759914006227 DNA binding loops [nucleotide binding] 759914006228 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 759914006229 Permease; Region: Permease; pfam02405 759914006230 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 759914006231 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 759914006232 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759914006233 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759914006234 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 759914006235 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 759914006236 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 759914006237 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 759914006238 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 759914006239 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 759914006240 catalytic site [active] 759914006241 G-X2-G-X-G-K; other site 759914006242 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 759914006243 NAD synthetase; Provisional; Region: PRK13981 759914006244 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 759914006245 multimer interface [polypeptide binding]; other site 759914006246 active site 759914006247 catalytic triad [active] 759914006248 protein interface 1 [polypeptide binding]; other site 759914006249 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 759914006250 Ligand Binding Site [chemical binding]; other site 759914006251 PSP1 C-terminal conserved region; Region: PSP1; cl00770 759914006252 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 759914006253 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 759914006254 active site 759914006255 HIGH motif; other site 759914006256 dimer interface [polypeptide binding]; other site 759914006257 KMSKS motif; other site 759914006258 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 759914006259 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 759914006260 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 759914006261 RNA binding site [nucleotide binding]; other site 759914006262 active site 759914006263 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759914006264 active site 759914006265 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 759914006266 GIY-YIG motif/motif A; other site 759914006267 putative active site [active] 759914006268 putative metal binding site [ion binding]; other site 759914006269 Bacterial Ig-like domain; Region: Big_5; pfam13205 759914006270 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 759914006271 MG2 domain; Region: A2M_N; pfam01835 759914006272 Alpha-2-macroglobulin family; Region: A2M; pfam00207 759914006273 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 759914006274 surface patch; other site 759914006275 thioester region; other site 759914006276 specificity defining residues; other site 759914006277 Predicted membrane protein [Function unknown]; Region: COG2364 759914006278 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 759914006279 GDP-Fucose binding site [chemical binding]; other site 759914006280 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 759914006281 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 759914006282 metal binding site [ion binding]; metal-binding site 759914006283 active site 759914006284 I-site; other site 759914006285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914006286 binding surface 759914006287 TPR motif; other site 759914006288 TPR repeat; Region: TPR_11; pfam13414 759914006289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759914006290 binding surface 759914006291 TPR motif; other site 759914006292 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 759914006293 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 759914006294 DNA polymerase I; Provisional; Region: PRK05755 759914006295 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 759914006296 active site 759914006297 metal binding site 1 [ion binding]; metal-binding site 759914006298 putative 5' ssDNA interaction site; other site 759914006299 metal binding site 3; metal-binding site 759914006300 metal binding site 2 [ion binding]; metal-binding site 759914006301 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 759914006302 putative DNA binding site [nucleotide binding]; other site 759914006303 putative metal binding site [ion binding]; other site 759914006304 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 759914006305 active site 759914006306 catalytic site [active] 759914006307 substrate binding site [chemical binding]; other site 759914006308 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 759914006309 active site 759914006310 DNA binding site [nucleotide binding] 759914006311 catalytic site [active] 759914006312 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 759914006313 active site residue [active] 759914006314 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 759914006315 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 759914006316 ligand binding site; other site 759914006317 oligomer interface; other site 759914006318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759914006319 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 759914006320 dimer interface [polypeptide binding]; other site 759914006321 N-terminal domain interface [polypeptide binding]; other site 759914006322 sulfate 1 binding site; other site 759914006323 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 759914006324 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 759914006325 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 759914006326 active site 759914006327 homodimer interface [polypeptide binding]; other site 759914006328 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 759914006329 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 759914006330 NADP binding site [chemical binding]; other site 759914006331 homopentamer interface [polypeptide binding]; other site 759914006332 substrate binding site [chemical binding]; other site 759914006333 active site 759914006334 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 759914006335 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 759914006336 adenylate kinase; Reviewed; Region: adk; PRK00279 759914006337 AMP-binding site [chemical binding]; other site 759914006338 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 759914006339 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 759914006340 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 759914006341 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 759914006342 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759914006343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914006344 homodimer interface [polypeptide binding]; other site 759914006345 catalytic residue [active] 759914006346 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914006347 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914006348 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759914006349 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 759914006350 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759914006351 nucleotide binding site [chemical binding]; other site 759914006352 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759914006353 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 759914006354 nucleotide binding site [chemical binding]; other site 759914006355 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759914006356 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 759914006357 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 759914006358 inhibitor binding site; inhibition site 759914006359 catalytic Zn binding site [ion binding]; other site 759914006360 structural Zn binding site [ion binding]; other site 759914006361 NADP binding site [chemical binding]; other site 759914006362 tetramer interface [polypeptide binding]; other site 759914006363 short chain dehydrogenase; Provisional; Region: PRK06114 759914006364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759914006365 NAD(P) binding site [chemical binding]; other site 759914006366 active site 759914006367 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759914006368 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 759914006369 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 759914006370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759914006371 Walker A/P-loop; other site 759914006372 ATP binding site [chemical binding]; other site 759914006373 Q-loop/lid; other site 759914006374 ABC transporter signature motif; other site 759914006375 Walker B; other site 759914006376 D-loop; other site 759914006377 H-loop/switch region; other site 759914006378 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 759914006379 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 759914006380 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 759914006381 TM-ABC transporter signature motif; other site 759914006382 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759914006383 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 759914006384 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 759914006385 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 759914006386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759914006387 catalytic residue [active] 759914006388 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 759914006389 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759914006390 Walker A/P-loop; other site 759914006391 ATP binding site [chemical binding]; other site 759914006392 Q-loop/lid; other site 759914006393 ABC transporter signature motif; other site 759914006394 Walker B; other site 759914006395 D-loop; other site 759914006396 H-loop/switch region; other site 759914006397 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 759914006398 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 759914006399 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759914006400 Walker A/P-loop; other site 759914006401 ATP binding site [chemical binding]; other site 759914006402 Q-loop/lid; other site 759914006403 ABC transporter signature motif; other site 759914006404 Walker B; other site 759914006405 D-loop; other site 759914006406 H-loop/switch region; other site 759914006407 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 759914006408 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914006409 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914006410 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914006411 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914006412 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914006413 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914006414 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914006415 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 759914006416 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 759914006417 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759914006418 Cache domain; Region: Cache_1; pfam02743 759914006419 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759914006420 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759914006421 dimer interface [polypeptide binding]; other site 759914006422 putative CheW interface [polypeptide binding]; other site 759914006423 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 759914006424 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 759914006425 active site 759914006426 FMN binding site [chemical binding]; other site 759914006427 substrate binding site [chemical binding]; other site 759914006428 homotetramer interface [polypeptide binding]; other site 759914006429 catalytic residue [active] 759914006430 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 759914006431 active site 759914006432 dimerization interface [polypeptide binding]; other site 759914006433 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759914006434 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 759914006435 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759914006436 Walker A/P-loop; other site 759914006437 ATP binding site [chemical binding]; other site 759914006438 Q-loop/lid; other site 759914006439 ABC transporter signature motif; other site 759914006440 Walker B; other site 759914006441 D-loop; other site 759914006442 H-loop/switch region; other site 759914006443 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 759914006444 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 759914006445 active site 759914006446 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 759914006447 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 759914006448 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 759914006449 dimer interface [polypeptide binding]; other site 759914006450 putative anticodon binding site; other site 759914006451 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 759914006452 motif 1; other site 759914006453 active site 759914006454 motif 2; other site 759914006455 motif 3; other site 759914006456 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 759914006457 Radical SAM superfamily; Region: Radical_SAM; pfam04055 759914006458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759914006459 FeS/SAM binding site; other site